{ "dbId" : 10910954, "stableId" : "R-DME-373760", "displayName" : "L1CAM interactions", "nodes" : [ { "id" : 31260, "reactomeId" : 10847552, "displayName" : "pL1:Ezrin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1480, "y" : 226 }, "minX" : 1419, "maxX" : 1518, "minY" : 209, "maxY" : 237, "prop" : { "x" : 1449, "y" : 215, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 1449, "y" : 216 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1512, "y" : 215 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1512, "y" : 215 } } }, "connectors" : [ { "edgeId" : 31259, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1446, "y" : 226 }, "to" : { "x" : 1419, "y" : 226 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31261, "reactomeId" : 10847512, "displayName" : "Homologues of L1CAM", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1420, "y" : 133 }, "minX" : 1390, "maxX" : 1450, "minY" : 122, "maxY" : 226, "prop" : { "x" : 1390, "y" : 122, "width" : 60, "height" : 23 }, "textPosition" : { "x" : 1390, "y" : 109 }, "connectors" : [ { "edgeId" : 31259, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1419, "y" : 148 }, "to" : { "x" : 1419, "y" : 226 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31262, "reactomeId" : 10847554, "displayName" : "L1 trans-homodimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1315, "y" : 227 }, "minX" : 1241, "maxX" : 1365, "minY" : 202, "maxY" : 246, "prop" : { "x" : 1271, "y" : 208, "width" : 88, "height" : 38 }, "textPosition" : { "x" : 1276, "y" : 211 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1359, "y" : 208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1359, "y" : 208 } } }, "connectors" : [ { "edgeId" : 31259, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31263, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1268, "y" : 226 }, "to" : { "x" : 1241, "y" : 226 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31264, "reactomeId" : 10849939, "displayName" : "F-actin", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 1296, "y" : 286 }, "minX" : 1241, "maxX" : 1322, "minY" : 226, "maxY" : 297, "prop" : { "x" : 1271, "y" : 275, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 1271, "y" : 275 }, "connectors" : [ { "edgeId" : 31263, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1285, "y" : 272 }, "to" : { "x" : 1241, "y" : 226 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31265, "reactomeId" : 10853370, "displayName" : "pL1:ERM:F-actin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1120, "y" : 227 }, "minX" : 1067, "maxX" : 1180, "minY" : 210, "maxY" : 238, "prop" : { "x" : 1067, "y" : 216, "width" : 107, "height" : 22 }, "textPosition" : { "x" : 1067, "y" : 217 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1174, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1174, "y" : 216 } } }, "connectors" : [ { "edgeId" : 31263, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31267, "reactomeId" : 10840677, "displayName" : "Clathrin:AP-2 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2165, "y" : 226 }, "minX" : 2114, "maxX" : 2222, "minY" : 193, "maxY" : 244, "prop" : { "x" : 2114, "y" : 208, "width" : 102, "height" : 36 }, "textPosition" : { "x" : 2119, "y" : 209 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2216, "y" : 208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2216, "y" : 208 } } }, "connectors" : [ { "edgeId" : 31266, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2139, "y" : 205 }, "to" : { "x" : 2119, "y" : 193 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31268, "reactomeId" : 10847512, "displayName" : "Homologues of L1CAM", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2041, "y" : 225 }, "minX" : 2011, "maxX" : 2809, "minY" : 157, "maxY" : 235, "prop" : { "x" : 2011, "y" : 215, "width" : 61, "height" : 20 }, "textPosition" : { "x" : 2012, "y" : 201 }, "connectors" : [ { "edgeId" : 31266, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2065, "y" : 212 }, "to" : { "x" : 2119, "y" : 193 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31325, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2049, "y" : 212 }, "to" : { "x" : 2099, "y" : 157 } }, { "from" : { "x" : 2099, "y" : 157 }, "to" : { "x" : 2727, "y" : 157 } }, { "from" : { "x" : 2727, "y" : 157 }, "to" : { "x" : 2809, "y" : 223 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31269, "reactomeId" : 10849918, "displayName" : "L1:clathrin-coated vesicle", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2294, "y" : 229 }, "minX" : 2235, "maxX" : 2359, "minY" : 205, "maxY" : 320, "prop" : { "x" : 2235, "y" : 211, "width" : 118, "height" : 36 }, "textPosition" : { "x" : 2245, "y" : 212 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2353, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2353, "y" : 211 } } }, "connectors" : [ { "edgeId" : 31266, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31270, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2293, "y" : 250 }, "to" : { "x" : 2293, "y" : 320 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31271, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2238, "y" : 313 }, "minX" : 2218, "maxX" : 2293, "minY" : 297, "maxY" : 328, "prop" : { "x" : 2218, "y" : 298, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2222, "y" : 302 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2253, "y" : 303 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2253, "y" : 303 } } }, "connectors" : [ { "edgeId" : 31270, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2261, "y" : 315 }, "to" : { "x" : 2293, "y" : 320 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31272, "reactomeId" : 10840682, "displayName" : "EndoA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2445, "y" : 224 }, "minX" : 2293, "maxX" : 2485, "minY" : 207, "maxY" : 320, "prop" : { "x" : 2411, "y" : 213, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 2421, "y" : 213 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2479, "y" : 213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2479, "y" : 213 } } }, "connectors" : [ { "edgeId" : 31270, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2427, "y" : 238 }, "to" : { "x" : 2293, "y" : 320 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31273, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2237, "y" : 408 }, "minX" : 2215, "maxX" : 2293, "minY" : 394, "maxY" : 422, "prop" : { "x" : 2215, "y" : 395, "width" : 44, "height" : 27 }, "textPosition" : { "x" : 2227, "y" : 398 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2254, "y" : 400 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2254, "y" : 400 } } }, "connectors" : [ { "edgeId" : 31270, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2262, "y" : 406 }, "to" : { "x" : 2293, "y" : 404 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2269, "y" : 402 }, "b" : { "x" : 2262, "y" : 406 }, "c" : { "x" : 2269, "y" : 410 }, "type" : "ARROW", "centre" : { "x" : 2269, "y" : 410 } } } ] }, { "id" : 31274, "reactomeId" : 10849922, "displayName" : "L1:AP-2 Clathrin complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2294, "y" : 547 }, "minX" : 2240, "maxX" : 2354, "minY" : 404, "maxY" : 565, "prop" : { "x" : 2240, "y" : 529, "width" : 108, "height" : 36 }, "textPosition" : { "x" : 2239, "y" : 530 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2348, "y" : 529 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2348, "y" : 529 } } }, "connectors" : [ { "edgeId" : 31270, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2293, "y" : 526 }, "to" : { "x" : 2293, "y" : 404 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2289, "y" : 519 }, "b" : { "x" : 2293, "y" : 526 }, "c" : { "x" : 2297, "y" : 519 }, "type" : "ARROW", "centre" : { "x" : 2297, "y" : 519 } } }, { "edgeId" : 31277, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31275, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2351, "y" : 416 }, "minX" : 2293, "maxX" : 2373, "minY" : 400, "maxY" : 431, "prop" : { "x" : 2331, "y" : 401, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2334, "y" : 405 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2367, "y" : 406 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2367, "y" : 406 } } }, "connectors" : [ { "edgeId" : 31270, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2328, "y" : 411 }, "to" : { "x" : 2293, "y" : 404 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2320, "y" : 414 }, "b" : { "x" : 2328, "y" : 411 }, "c" : { "x" : 2322, "y" : 406 }, "type" : "ARROW", "centre" : { "x" : 2322, "y" : 406 } } } ] }, { "id" : 31276, "reactomeId" : 10856574, "displayName" : "Dynamin-1/2/3", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2547, "y" : 225 }, "minX" : 2301, "maxX" : 2598, "minY" : 214, "maxY" : 367, "prop" : { "x" : 2497, "y" : 214, "width" : 101, "height" : 22 }, "textPosition" : { "x" : 2499, "y" : 214 }, "connectors" : [ { "edgeId" : 31270, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2532, "y" : 242 }, "to" : { "x" : 2362, "y" : 363 } }, { "from" : { "x" : 2362, "y" : 363 }, "to" : { "x" : 2309, "y" : 363 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2305, "y" : 363 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2305, "y" : 363 } } } ] }, { "id" : 31279, "reactomeId" : 10849922, "displayName" : "L1:AP-2 Clathrin complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2069, "y" : 547 }, "minX" : 1972, "maxX" : 2129, "minY" : 511, "maxY" : 565, "prop" : { "x" : 2015, "y" : 529, "width" : 108, "height" : 36 }, "textPosition" : { "x" : 2014, "y" : 530 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2123, "y" : 529 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2123, "y" : 529 } } }, "connectors" : [ { "edgeId" : 31278, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2020, "y" : 526 }, "to" : { "x" : 1972, "y" : 511 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31280, "reactomeId" : 10835990, "displayName" : "phospho-p-T185,Y187-MAPK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1941, "y" : 406 }, "minX" : 1895, "maxX" : 1993, "minY" : 378, "maxY" : 511, "prop" : { "x" : 1895, "y" : 384, "width" : 92, "height" : 44 }, "textPosition" : { "x" : 1901, "y" : 382 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1987, "y" : 384 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1987, "y" : 384 } } }, "connectors" : [ { "edgeId" : 31278, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1947, "y" : 431 }, "to" : { "x" : 1972, "y" : 511 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31278, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1939, "y" : 431 }, "to" : { "x" : 1934, "y" : 495 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1934, "y" : 499 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1934, "y" : 499 } } } ] }, { "id" : 31281, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2012, "y" : 438 }, "minX" : 1972, "maxX" : 2033, "minY" : 422, "maxY" : 511, "prop" : { "x" : 1993, "y" : 423, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1997, "y" : 427 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2027, "y" : 428 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2027, "y" : 428 } } }, "connectors" : [ { "edgeId" : 31278, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2003, "y" : 456 }, "to" : { "x" : 1972, "y" : 511 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31282, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1863, "y" : 435 }, "minX" : 1843, "maxX" : 1898, "minY" : 419, "maxY" : 511, "prop" : { "x" : 1843, "y" : 420, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1846, "y" : 424 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1878, "y" : 425 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1878, "y" : 425 } } }, "connectors" : [ { "edgeId" : 31278, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1869, "y" : 453 }, "to" : { "x" : 1898, "y" : 511 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1876, "y" : 457 }, "b" : { "x" : 1869, "y" : 453 }, "c" : { "x" : 1869, "y" : 461 }, "type" : "ARROW", "centre" : { "x" : 1869, "y" : 461 } } } ] }, { "id" : 31283, "reactomeId" : 10853729, "displayName" : "pL1 (S1204, 1248):ERK2:clathrin-dynamin complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1778, "y" : 511 }, "minX" : 1714, "maxX" : 1898, "minY" : 480, "maxY" : 536, "prop" : { "x" : 1714, "y" : 486, "width" : 129, "height" : 50 }, "textPosition" : { "x" : 1714, "y" : 487 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1843, "y" : 486 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1843, "y" : 486 } } }, "connectors" : [ { "edgeId" : 31278, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1846, "y" : 511 }, "to" : { "x" : 1898, "y" : 511 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1853, "y" : 507 }, "b" : { "x" : 1846, "y" : 511 }, "c" : { "x" : 1853, "y" : 515 }, "type" : "ARROW", "centre" : { "x" : 1853, "y" : 515 } } } ] }, { "id" : 31285, "reactomeId" : 10849937, "displayName" : "L1 trans-homodimer:Ankyrin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 779, "y" : 217 }, "minX" : 702, "maxX" : 849, "minY" : 193, "maxY" : 235, "prop" : { "x" : 715, "y" : 199, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 715, "y" : 200 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 843, "y" : 199 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 843, "y" : 199 } } }, "connectors" : [ { "edgeId" : 31284, "type" : "INPUT", "segments" : [ { "from" : { "x" : 712, "y" : 217 }, "to" : { "x" : 702, "y" : 217 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31286, "reactomeId" : 10849941, "displayName" : "SPTA:SPTB:F-actin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 679, "y" : 264 }, "minX" : 617, "maxX" : 748, "minY" : 217, "maxY" : 275, "prop" : { "x" : 617, "y" : 253, "width" : 125, "height" : 22 }, "textPosition" : { "x" : 619, "y" : 254 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 742, "y" : 253 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 742, "y" : 253 } } }, "connectors" : [ { "edgeId" : 31284, "type" : "INPUT", "segments" : [ { "from" : { "x" : 684, "y" : 250 }, "to" : { "x" : 702, "y" : 217 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31287, "reactomeId" : 10849943, "displayName" : "L1 dimer:Ankyrin:Spectrin:F-actin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 600, "y" : 219 }, "minX" : 543, "maxX" : 664, "minY" : 195, "maxY" : 237, "prop" : { "x" : 543, "y" : 201, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 543, "y" : 202 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 658, "y" : 201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 658, "y" : 201 } } }, "connectors" : [ { "edgeId" : 31284, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31289, "reactomeId" : 10847623, "displayName" : "Homologues of NCAM1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 4178, "y" : 1131 }, "minX" : 4142, "maxX" : 4208, "minY" : 876, "maxY" : 1145, "prop" : { "x" : 4149, "y" : 1117, "width" : 59, "height" : 28 }, "textPosition" : { "x" : 4149, "y" : 1107 }, "connectors" : [ { "edgeId" : 31288, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4176, "y" : 1114 }, "to" : { "x" : 4142, "y" : 876 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31290, "reactomeId" : 10847512, "displayName" : "Homologues of L1CAM", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 4067, "y" : 525 }, "minX" : 3437, "maxX" : 4142, "minY" : 227, "maxY" : 978, "prop" : { "x" : 4039, "y" : 514, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 4038, "y" : 501 }, "connectors" : [ { "edgeId" : 31296, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4036, "y" : 518 }, "to" : { "x" : 3757, "y" : 452 } }, { "from" : { "x" : 3757, "y" : 452 }, "to" : { "x" : 3437, "y" : 228 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31330, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4057, "y" : 539 }, "to" : { "x" : 3862, "y" : 775 } }, { "from" : { "x" : 3862, "y" : 775 }, "to" : { "x" : 3878, "y" : 978 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31299, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4050, "y" : 511 }, "to" : { "x" : 3699, "y" : 273 } }, { "from" : { "x" : 3699, "y" : 273 }, "to" : { "x" : 3684, "y" : 227 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31288, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4086, "y" : 539 }, "to" : { "x" : 4142, "y" : 567 } }, { "from" : { "x" : 4142, "y" : 567 }, "to" : { "x" : 4142, "y" : 876 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31291, "reactomeId" : 10847625, "displayName" : "L1:NCAM1 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4080, "y" : 934 }, "minX" : 4032, "maxX" : 4135, "minY" : 910, "maxY" : 952, "prop" : { "x" : 4032, "y" : 916, "width" : 97, "height" : 36 }, "textPosition" : { "x" : 4044, "y" : 917 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4129, "y" : 916 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4129, "y" : 916 } } }, "connectors" : [ { "edgeId" : 31288, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31293, "reactomeId" : 10849935, "displayName" : "L1 homodimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 897, "y" : 221 }, "minX" : 849, "maxX" : 952, "minY" : 137, "maxY" : 232, "prop" : { "x" : 849, "y" : 210, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 849, "y" : 211 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 946, "y" : 210 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 946, "y" : 210 } } }, "connectors" : [ { "edgeId" : 31292, "type" : "INPUT", "segments" : [ { "from" : { "x" : 898, "y" : 207 }, "to" : { "x" : 910, "y" : 137 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31294, "reactomeId" : 10841552, "displayName" : "FGFR1c", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 848, "y" : 138 }, "minX" : 816, "maxX" : 910, "minY" : 119, "maxY" : 152, "prop" : { "x" : 816, "y" : 125, "width" : 65, "height" : 27 }, "textPosition" : { "x" : 821, "y" : 128 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 881, "y" : 125 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 881, "y" : 125 } } }, "connectors" : [ { "edgeId" : 31292, "type" : "INPUT", "segments" : [ { "from" : { "x" : 884, "y" : 137 }, "to" : { "x" : 910, "y" : 137 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31295, "reactomeId" : 10853166, "displayName" : "L1:FGFR1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1016, "y" : 137 }, "minX" : 983, "maxX" : 1055, "minY" : 120, "maxY" : 148, "prop" : { "x" : 983, "y" : 126, "width" : 66, "height" : 22 }, "textPosition" : { "x" : 983, "y" : 127 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1049, "y" : 126 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1049, "y" : 126 } } }, "connectors" : [ { "edgeId" : 31292, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31297, "reactomeId" : 10840711, "displayName" : "EGFR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3394, "y" : 228 }, "minX" : 3374, "maxX" : 3437, "minY" : 211, "maxY" : 239, "prop" : { "x" : 3374, "y" : 217, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 3374, "y" : 217 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3415, "y" : 217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3415, "y" : 217 } } }, "connectors" : [ { "edgeId" : 31296, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3418, "y" : 228 }, "to" : { "x" : 3437, "y" : 228 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31298, "reactomeId" : 10853582, "displayName" : "L1-EGFR trans-heterodimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3540, "y" : 229 }, "minX" : 3491, "maxX" : 3596, "minY" : 205, "maxY" : 247, "prop" : { "x" : 3491, "y" : 211, "width" : 99, "height" : 36 }, "textPosition" : { "x" : 3491, "y" : 212 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3590, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3590, "y" : 211 } } }, "connectors" : [ { "edgeId" : 31296, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31300, "reactomeId" : 10847633, "displayName" : "Integrins", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3629, "y" : 228 }, "minX" : 3597, "maxX" : 3684, "minY" : 217, "maxY" : 239, "prop" : { "x" : 3597, "y" : 217, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 3597, "y" : 217 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 31299, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3667, "y" : 227 }, "to" : { "x" : 3684, "y" : 227 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31301, "reactomeId" : 10847635, "displayName" : "L1:Integrin complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3784, "y" : 227 }, "minX" : 3746, "maxX" : 3828, "minY" : 203, "maxY" : 246, "prop" : { "x" : 3746, "y" : 209, "width" : 76, "height" : 37 }, "textPosition" : { "x" : 3745, "y" : 211 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3822, "y" : 209 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3822, "y" : 209 } } }, "connectors" : [ { "edgeId" : 31299, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31303, "reactomeId" : 428485, "displayName" : "Rac1:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3030, "y" : 610 }, "minX" : 2986, "maxX" : 3072, "minY" : 579, "maxY" : 621, "prop" : { "x" : 2994, "y" : 599, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 2995, "y" : 600 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3066, "y" : 599 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3066, "y" : 599 } } }, "connectors" : [ { "edgeId" : 31302, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3014, "y" : 596 }, "to" : { "x" : 2986, "y" : 579 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31304, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3032, "y" : 542 }, "minX" : 2986, "maxX" : 3053, "minY" : 526, "maxY" : 579, "prop" : { "x" : 3012, "y" : 527, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 3016, "y" : 531 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3047, "y" : 532 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3047, "y" : 532 } } }, "connectors" : [ { "edgeId" : 31302, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3013, "y" : 560 }, "to" : { "x" : 2986, "y" : 579 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31305, "reactomeId" : 351067, "displayName" : "RAC1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2868, "y" : 535 }, "minX" : 2833, "maxX" : 2915, "minY" : 477, "maxY" : 579, "prop" : { "x" : 2833, "y" : 524, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 2834, "y" : 525 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2904, "y" : 524 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2904, "y" : 524 } } }, "connectors" : [ { "edgeId" : 31302, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2879, "y" : 549 }, "to" : { "x" : 2915, "y" : 579 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2887, "y" : 550 }, "b" : { "x" : 2879, "y" : 549 }, "c" : { "x" : 2882, "y" : 557 }, "type" : "ARROW", "centre" : { "x" : 2882, "y" : 557 } } }, { "edgeId" : 31308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2868, "y" : 521 }, "to" : { "x" : 2868, "y" : 477 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31306, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2866, "y" : 621 }, "minX" : 2846, "maxX" : 2915, "minY" : 579, "maxY" : 636, "prop" : { "x" : 2846, "y" : 606, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2849, "y" : 610 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2882, "y" : 611 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2882, "y" : 611 } } }, "connectors" : [ { "edgeId" : 31302, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2883, "y" : 603 }, "to" : { "x" : 2915, "y" : 579 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2886, "y" : 596 }, "b" : { "x" : 2883, "y" : 603 }, "c" : { "x" : 2891, "y" : 602 }, "type" : "ARROW", "centre" : { "x" : 2891, "y" : 602 } } } ] }, { "id" : 31307, "reactomeId" : 10853236, "displayName" : "phospho-Vav", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2949, "y" : 677 }, "minX" : 2902, "maxX" : 3002, "minY" : 587, "maxY" : 688, "prop" : { "x" : 2902, "y" : 666, "width" : 94, "height" : 22 }, "textPosition" : { "x" : 2904, "y" : 666 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2996, "y" : 666 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2996, "y" : 666 } } }, "connectors" : [ { "edgeId" : 31302, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2949, "y" : 663 }, "to" : { "x" : 2950, "y" : 595 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2950, "y" : 591 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2950, "y" : 591 } } } ] }, { "id" : 31309, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2810, "y" : 430 }, "minX" : 2791, "maxX" : 2868, "minY" : 414, "maxY" : 477, "prop" : { "x" : 2791, "y" : 415, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2795, "y" : 419 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2825, "y" : 420 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2825, "y" : 420 } } }, "connectors" : [ { "edgeId" : 31308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2828, "y" : 448 }, "to" : { "x" : 2868, "y" : 477 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2842, "y" : 456 }, "b" : { "x" : 2854, "y" : 468 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2848, "y" : 462 } } } } ] }, { "id" : 31310, "reactomeId" : 10849376, "displayName" : "PAK1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2789, "y" : 477 }, "minX" : 2747, "maxX" : 2868, "minY" : 460, "maxY" : 489, "prop" : { "x" : 2747, "y" : 466, "width" : 85, "height" : 23 }, "textPosition" : { "x" : 2750, "y" : 468 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2832, "y" : 466 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2832, "y" : 466 } } }, "connectors" : [ { "edgeId" : 31308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2835, "y" : 477 }, "to" : { "x" : 2868, "y" : 477 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31311, "reactomeId" : 10849374, "displayName" : "Homologues of PAK1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2907, "y" : 407 }, "minX" : 2888, "maxX" : 2950, "minY" : 396, "maxY" : 477, "prop" : { "x" : 2888, "y" : 396, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 2888, "y" : 369 }, "connectors" : [ { "edgeId" : 31308, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2913, "y" : 421 }, "to" : { "x" : 2950, "y" : 477 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2920, "y" : 425 }, "b" : { "x" : 2913, "y" : 421 }, "c" : { "x" : 2913, "y" : 429 }, "type" : "ARROW", "centre" : { "x" : 2913, "y" : 429 } } }, { "edgeId" : 31308, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2907, "y" : 421 }, "to" : { "x" : 2908, "y" : 461 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2908, "y" : 465 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2908, "y" : 465 } } } ] }, { "id" : 31312, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2979, "y" : 410 }, "minX" : 2950, "maxX" : 3000, "minY" : 394, "maxY" : 477, "prop" : { "x" : 2959, "y" : 395, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2962, "y" : 399 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2994, "y" : 400 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2994, "y" : 400 } } }, "connectors" : [ { "edgeId" : 31308, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2972, "y" : 428 }, "to" : { "x" : 2950, "y" : 477 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2955, "y" : 446 }, "b" : { "x" : 2967, "y" : 458 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2961, "y" : 452 } } }, "endShape" : { "a" : { "x" : 2973, "y" : 436 }, "b" : { "x" : 2972, "y" : 428 }, "c" : { "x" : 2966, "y" : 433 }, "type" : "ARROW", "centre" : { "x" : 2966, "y" : 433 } } } ] }, { "id" : 31313, "reactomeId" : 10853683, "displayName" : "pPAK1:Rac1-GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3050, "y" : 478 }, "minX" : 2950, "maxX" : 3112, "minY" : 461, "maxY" : 489, "prop" : { "x" : 2995, "y" : 467, "width" : 111, "height" : 22 }, "textPosition" : { "x" : 2995, "y" : 468 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3106, "y" : 467 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3106, "y" : 467 } } }, "connectors" : [ { "edgeId" : 31308, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2992, "y" : 477 }, "to" : { "x" : 2950, "y" : 477 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2985, "y" : 481 }, "b" : { "x" : 2992, "y" : 477 }, "c" : { "x" : 2985, "y" : 473 }, "type" : "ARROW", "centre" : { "x" : 2985, "y" : 473 } } } ] }, { "id" : 31315, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3417, "y" : 601 }, "minX" : 3361, "maxX" : 3438, "minY" : 558, "maxY" : 616, "prop" : { "x" : 3398, "y" : 586, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 3402, "y" : 590 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3432, "y" : 591 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3432, "y" : 591 } } }, "connectors" : [ { "edgeId" : 31314, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3395, "y" : 586 }, "to" : { "x" : 3361, "y" : 558 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3372, "y" : 566 }, "b" : { "x" : 3384, "y" : 578 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3378, "y" : 572 } } } } ] }, { "id" : 31316, "reactomeId" : 10835958, "displayName" : "p-2S-MAP2K1:MAPK3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3405, "y" : 505 }, "minX" : 3316, "maxX" : 3458, "minY" : 481, "maxY" : 558, "prop" : { "x" : 3358, "y" : 487, "width" : 94, "height" : 36 }, "textPosition" : { "x" : 3358, "y" : 488 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3452, "y" : 487 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3452, "y" : 487 } } }, "connectors" : [ { "edgeId" : 31314, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3390, "y" : 526 }, "to" : { "x" : 3361, "y" : 558 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31314, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3355, "y" : 504 }, "to" : { "x" : 3319, "y" : 504 } }, { "from" : { "x" : 3319, "y" : 504 }, "to" : { "x" : 3320, "y" : 542 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3320, "y" : 546 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3320, "y" : 546 } } } ] }, { "id" : 31317, "reactomeId" : 10835974, "displayName" : "p-T,Y-MAPK3:p-2S-MAP2K1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3215, "y" : 505 }, "minX" : 3162, "maxX" : 3275, "minY" : 481, "maxY" : 558, "prop" : { "x" : 3162, "y" : 487, "width" : 107, "height" : 36 }, "textPosition" : { "x" : 3166, "y" : 488 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3269, "y" : 487 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3269, "y" : 487 } } }, "connectors" : [ { "edgeId" : 31314, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3234, "y" : 526 }, "to" : { "x" : 3272, "y" : 558 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3242, "y" : 527 }, "b" : { "x" : 3234, "y" : 526 }, "c" : { "x" : 3237, "y" : 534 }, "type" : "ARROW", "centre" : { "x" : 3237, "y" : 534 } } } ] }, { "id" : 31318, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3215, "y" : 601 }, "minX" : 3195, "maxX" : 3272, "minY" : 558, "maxY" : 616, "prop" : { "x" : 3195, "y" : 586, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 3198, "y" : 590 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3230, "y" : 591 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3230, "y" : 591 } } }, "connectors" : [ { "edgeId" : 31314, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3234, "y" : 583 }, "to" : { "x" : 3272, "y" : 558 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3247, "y" : 564 }, "b" : { "x" : 3259, "y" : 576 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3253, "y" : 570 } } }, "endShape" : { "a" : { "x" : 3238, "y" : 576 }, "b" : { "x" : 3234, "y" : 583 }, "c" : { "x" : 3242, "y" : 583 }, "type" : "ARROW", "centre" : { "x" : 3242, "y" : 583 } } } ] }, { "id" : 31319, "reactomeId" : 10835983, "displayName" : "p-2T-MAP2K1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3320, "y" : 617 }, "minX" : 3272, "maxX" : 3368, "minY" : 567, "maxY" : 629, "prop" : { "x" : 3272, "y" : 606, "width" : 96, "height" : 23 }, "textPosition" : { "x" : 3276, "y" : 607 }, "connectors" : [ { "edgeId" : 31314, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 3320, "y" : 600 }, "to" : { "x" : 3320, "y" : 567 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3316, "y" : 567 }, "b" : { "x" : 3324, "y" : 567 }, "c" : { "x" : 3320, "y" : 567 }, "type" : "STOP", "centre" : { "x" : 3320, "y" : 567 } } } ] }, { "id" : 31321, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3405, "y" : 356 }, "minX" : 3359, "maxX" : 3426, "minY" : 340, "maxY" : 402, "prop" : { "x" : 3386, "y" : 341, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 3390, "y" : 345 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3420, "y" : 346 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3420, "y" : 346 } } }, "connectors" : [ { "edgeId" : 31320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3390, "y" : 374 }, "to" : { "x" : 3359, "y" : 402 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3368, "y" : 382 }, "b" : { "x" : 3380, "y" : 394 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3374, "y" : 388 } } } } ] }, { "id" : 31322, "reactomeId" : 10835966, "displayName" : "p-S,T-MAP2K2:MAPK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3405, "y" : 451 }, "minX" : 3312, "maxX" : 3460, "minY" : 402, "maxY" : 469, "prop" : { "x" : 3357, "y" : 433, "width" : 97, "height" : 36 }, "textPosition" : { "x" : 3357, "y" : 434 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3454, "y" : 433 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3454, "y" : 433 } } }, "connectors" : [ { "edgeId" : 31320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3388, "y" : 430 }, "to" : { "x" : 3359, "y" : 402 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31320, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3354, "y" : 451 }, "to" : { "x" : 3316, "y" : 451 } }, { "from" : { "x" : 3316, "y" : 451 }, "to" : { "x" : 3316, "y" : 418 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3316, "y" : 414 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3316, "y" : 414 } } } ] }, { "id" : 31323, "reactomeId" : 10835992, "displayName" : "p-S,T-MAP2K2:p-T,Y-MAPK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3215, "y" : 451 }, "minX" : 3162, "maxX" : 3275, "minY" : 402, "maxY" : 469, "prop" : { "x" : 3162, "y" : 433, "width" : 107, "height" : 36 }, "textPosition" : { "x" : 3167, "y" : 434 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3269, "y" : 433 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3269, "y" : 433 } } }, "connectors" : [ { "edgeId" : 31320, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3235, "y" : 430 }, "to" : { "x" : 3271, "y" : 402 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3238, "y" : 423 }, "b" : { "x" : 3235, "y" : 430 }, "c" : { "x" : 3243, "y" : 429 }, "type" : "ARROW", "centre" : { "x" : 3243, "y" : 429 } } } ] }, { "id" : 31324, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3215, "y" : 356 }, "minX" : 3195, "maxX" : 3271, "minY" : 340, "maxY" : 402, "prop" : { "x" : 3195, "y" : 341, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 3198, "y" : 345 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3230, "y" : 346 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3230, "y" : 346 } } }, "connectors" : [ { "edgeId" : 31320, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3233, "y" : 374 }, "to" : { "x" : 3271, "y" : 402 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3246, "y" : 382 }, "b" : { "x" : 3258, "y" : 394 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3252, "y" : 388 } } }, "endShape" : { "a" : { "x" : 3241, "y" : 375 }, "b" : { "x" : 3233, "y" : 374 }, "c" : { "x" : 3236, "y" : 381 }, "type" : "ARROW", "centre" : { "x" : 3236, "y" : 381 } } } ] }, { "id" : 31326, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2757, "y" : 294 }, "minX" : 2738, "maxX" : 2809, "minY" : 223, "maxY" : 309, "prop" : { "x" : 2738, "y" : 279, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2742, "y" : 283 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2772, "y" : 284 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2772, "y" : 284 } } }, "connectors" : [ { "edgeId" : 31325, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2767, "y" : 276 }, "to" : { "x" : 2809, "y" : 223 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31327, "reactomeId" : 10843870, "displayName" : "Casein kinase II", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2862, "y" : 351 }, "minX" : 2809, "maxX" : 2921, "minY" : 223, "maxY" : 362, "prop" : { "x" : 2809, "y" : 340, "width" : 106, "height" : 22 }, "textPosition" : { "x" : 2809, "y" : 341 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2915, "y" : 340 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2915, "y" : 340 } } }, "connectors" : [ { "edgeId" : 31325, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2857, "y" : 337 }, "to" : { "x" : 2809, "y" : 223 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31325, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2862, "y" : 337 }, "to" : { "x" : 2863, "y" : 239 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2863, "y" : 235 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2863, "y" : 235 } } } ] }, { "id" : 31328, "reactomeId" : 10849964, "displayName" : "pL1:CK-II", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2996, "y" : 225 }, "minX" : 2899, "maxX" : 3034, "minY" : 208, "maxY" : 236, "prop" : { "x" : 2965, "y" : 214, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 2967, "y" : 215 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3028, "y" : 214 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3028, "y" : 214 } } }, "connectors" : [ { "edgeId" : 31325, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2962, "y" : 224 }, "to" : { "x" : 2899, "y" : 223 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2955, "y" : 228 }, "b" : { "x" : 2962, "y" : 224 }, "c" : { "x" : 2955, "y" : 220 }, "type" : "ARROW", "centre" : { "x" : 2955, "y" : 220 } } } ] }, { "id" : 31329, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2960, "y" : 299 }, "minX" : 2899, "maxX" : 2981, "minY" : 223, "maxY" : 314, "prop" : { "x" : 2940, "y" : 284, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2943, "y" : 288 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2975, "y" : 289 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2975, "y" : 289 } } }, "connectors" : [ { "edgeId" : 31325, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2947, "y" : 281 }, "to" : { "x" : 2899, "y" : 223 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2940, "y" : 278 }, "b" : { "x" : 2947, "y" : 281 }, "c" : { "x" : 2946, "y" : 273 }, "type" : "ARROW", "centre" : { "x" : 2946, "y" : 273 } } } ] }, { "id" : 31331, "reactomeId" : 10847517, "displayName" : "RanBPM", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3933, "y" : 979 }, "minX" : 3878, "maxX" : 3971, "minY" : 962, "maxY" : 990, "prop" : { "x" : 3902, "y" : 968, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 3904, "y" : 968 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3965, "y" : 968 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3965, "y" : 968 } } }, "connectors" : [ { "edgeId" : 31330, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3899, "y" : 978 }, "to" : { "x" : 3878, "y" : 978 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31332, "reactomeId" : 10847519, "displayName" : "L1:RanBPM", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3783, "y" : 978 }, "minX" : 3745, "maxX" : 3828, "minY" : 961, "maxY" : 989, "prop" : { "x" : 3745, "y" : 967, "width" : 77, "height" : 22 }, "textPosition" : { "x" : 3745, "y" : 968 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3822, "y" : 967 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3822, "y" : 967 } } }, "connectors" : [ { "edgeId" : 31330, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31334, "reactomeId" : 10853364, "displayName" : "Neurofascin:Ankyrin-G complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 499, "y" : 966 }, "minX" : 451, "maxX" : 575, "minY" : 936, "maxY" : 990, "prop" : { "x" : 451, "y" : 942, "width" : 97, "height" : 48 }, "textPosition" : { "x" : 456, "y" : 941 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 548, "y" : 942 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 548, "y" : 942 } } }, "connectors" : [ { "edgeId" : 31333, "type" : "INPUT", "segments" : [ { "from" : { "x" : 551, "y" : 966 }, "to" : { "x" : 575, "y" : 966 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31335, "reactomeId" : 10847367, "displayName" : "Homologues of NFASC", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 591, "y" : 1129 }, "minX" : 553, "maxX" : 629, "minY" : 966, "maxY" : 1140, "prop" : { "x" : 553, "y" : 1118, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 555, "y" : 1105 }, "connectors" : [ { "edgeId" : 31333, "type" : "INPUT", "segments" : [ { "from" : { "x" : 589, "y" : 1115 }, "to" : { "x" : 575, "y" : 966 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31336, "reactomeId" : 10853366, "displayName" : "Trans neurofascin dimer:ankyrin-G", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 691, "y" : 967 }, "minX" : 628, "maxX" : 760, "minY" : 943, "maxY" : 985, "prop" : { "x" : 628, "y" : 949, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 628, "y" : 950 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 754, "y" : 949 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 754, "y" : 949 } } }, "connectors" : [ { "edgeId" : 31333, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31338, "reactomeId" : 10847384, "displayName" : "CG7472", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 93, "y" : 828 }, "minX" : 35, "maxX" : 134, "minY" : 808, "maxY" : 839, "prop" : { "x" : 58, "y" : 817, "width" : 70, "height" : 22 }, "textPosition" : { "x" : 64, "y" : 817 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 128, "y" : 817 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 128, "y" : 817 } } }, "connectors" : [ { "edgeId" : 31337, "type" : "INPUT", "segments" : [ { "from" : { "x" : 61, "y" : 814 }, "to" : { "x" : 35, "y" : 808 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31339, "reactomeId" : 10847367, "displayName" : "Homologues of NFASC", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 94, "y" : 765 }, "minX" : 6, "maxX" : 132, "minY" : 754, "maxY" : 808, "prop" : { "x" : 56, "y" : 754, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 58, "y" : 741 }, "connectors" : [ { "edgeId" : 31337, "type" : "INPUT", "segments" : [ { "from" : { "x" : 78, "y" : 779 }, "to" : { "x" : 35, "y" : 808 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31341, "type" : "INPUT", "segments" : [ { "from" : { "x" : 53, "y" : 765 }, "to" : { "x" : 6, "y" : 765 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31340, "reactomeId" : 10847386, "displayName" : "Neurofascin:Syntenin-1 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 113, "y" : 894 }, "minX" : 69, "maxX" : 163, "minY" : 863, "maxY" : 920, "prop" : { "x" : 69, "y" : 869, "width" : 88, "height" : 51 }, "textPosition" : { "x" : 69, "y" : 871 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 157, "y" : 869 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 157, "y" : 869 } } }, "connectors" : [ { "edgeId" : 31337, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31342, "reactomeId" : 10847373, "displayName" : "Homologues of NRCAM", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 96, "y" : 388 }, "minX" : 6, "maxX" : 122, "minY" : 377, "maxY" : 765, "prop" : { "x" : 70, "y" : 377, "width" : 52, "height" : 22 }, "textPosition" : { "x" : 70, "y" : 357 }, "connectors" : [ { "edgeId" : 31341, "type" : "INPUT", "segments" : [ { "from" : { "x" : 67, "y" : 392 }, "to" : { "x" : 6, "y" : 404 } }, { "from" : { "x" : 6, "y" : 404 }, "to" : { "x" : 6, "y" : 765 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31343, "reactomeId" : 10847375, "displayName" : "NFASC:NRCAM", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 100, "y" : 970 }, "minX" : 47, "maxX" : 160, "minY" : 946, "maxY" : 988, "prop" : { "x" : 47, "y" : 952, "width" : 107, "height" : 36 }, "textPosition" : { "x" : 53, "y" : 967 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 154, "y" : 952 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 154, "y" : 952 } } }, "connectors" : [ { "edgeId" : 31341, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31345, "reactomeId" : 10897480, "displayName" : "igl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1306, "y" : 1007 }, "minX" : 1245, "maxX" : 1414, "minY" : 990, "maxY" : 1018, "prop" : { "x" : 1245, "y" : 996, "width" : 122, "height" : 22 }, "textPosition" : { "x" : 1295, "y" : 996 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1367, "y" : 996 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1367, "y" : 996 } } }, "connectors" : [ { "edgeId" : 31344, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1370, "y" : 1006 }, "to" : { "x" : 1414, "y" : 1006 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31346, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1356, "y" : 964 }, "minX" : 1335, "maxX" : 1414, "minY" : 948, "maxY" : 1006, "prop" : { "x" : 1335, "y" : 949, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1339, "y" : 953 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1373, "y" : 954 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1373, "y" : 954 } } }, "connectors" : [ { "edgeId" : 31344, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1376, "y" : 982 }, "to" : { "x" : 1414, "y" : 1006 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1389, "y" : 988 }, "b" : { "x" : 1401, "y" : 1000 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1395, "y" : 994 } } } } ], "trivial" : true }, { "id" : 31347, "reactomeId" : 10897482, "displayName" : "igl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1603, "y" : 1006 }, "minX" : 1515, "maxX" : 1634, "minY" : 989, "maxY" : 1017, "prop" : { "x" : 1579, "y" : 995, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 1592, "y" : 995 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1628, "y" : 995 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1628, "y" : 995 } } }, "connectors" : [ { "edgeId" : 31344, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1576, "y" : 1006 }, "to" : { "x" : 1515, "y" : 1006 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1569, "y" : 1010 }, "b" : { "x" : 1576, "y" : 1006 }, "c" : { "x" : 1569, "y" : 1002 }, "type" : "ARROW", "centre" : { "x" : 1569, "y" : 1002 } } } ] }, { "id" : 31348, "reactomeId" : 3632881, "displayName" : "PALM", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1556, "y" : 950 }, "minX" : 1515, "maxX" : 1581, "minY" : 934, "maxY" : 1006, "prop" : { "x" : 1532, "y" : 935, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1536, "y" : 939 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1575, "y" : 940 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1575, "y" : 940 } } }, "connectors" : [ { "edgeId" : 31344, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1545, "y" : 968 }, "to" : { "x" : 1515, "y" : 1006 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1524, "y" : 981 }, "b" : { "x" : 1536, "y" : 993 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1530, "y" : 987 } } }, "endShape" : { "a" : { "x" : 1544, "y" : 976 }, "b" : { "x" : 1545, "y" : 968 }, "c" : { "x" : 1538, "y" : 971 }, "type" : "ARROW", "centre" : { "x" : 1538, "y" : 971 } } } ] }, { "id" : 31349, "reactomeId" : 10897484, "displayName" : "Apt1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1463, "y" : 1060 }, "minX" : 1438, "maxX" : 1495, "minY" : 1014, "maxY" : 1071, "prop" : { "x" : 1438, "y" : 1049, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 1445, "y" : 1049 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1489, "y" : 1049 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1489, "y" : 1049 } } }, "connectors" : [ { "edgeId" : 31344, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1463, "y" : 1046 }, "to" : { "x" : 1463, "y" : 1022 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1463, "y" : 1018 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1463, "y" : 1018 } } } ] } ], "edges" : [ { "id" : 31296, "reactomeId" : 10853584, "displayName" : "L1-EGFR trans-heterodimerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3458, "y" : 228 }, "minX" : 3437, "maxX" : 3488, "minY" : 222, "maxY" : 234, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3437, "y" : 228 }, "to" : { "x" : 3458, "y" : 228 } }, { "from" : { "x" : 3458, "y" : 228 }, "to" : { "x" : 3488, "y" : 228 } } ], "endShape" : { "a" : { "x" : 3481, "y" : 232 }, "b" : { "x" : 3488, "y" : 228 }, "c" : { "x" : 3481, "y" : 224 }, "type" : "ARROW", "centre" : { "x" : 3481, "y" : 224 } }, "reactionShape" : { "c" : { "x" : 3458, "y" : 228 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3458, "y" : 228 } }, "inputs" : [ { "id" : 31297, "points" : [ { "x" : 3418, "y" : 228 } ] }, { "id" : 31290, "points" : [ { "x" : 4036, "y" : 518 }, { "x" : 3757, "y" : 452 } ] } ], "outputs" : [ { "id" : 31298 } ] }, { "id" : 31330, "reactomeId" : 10847521, "displayName" : "L1 binds RanBPM", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3850, "y" : 978 }, "minX" : 3825, "maxX" : 3878, "minY" : 972, "maxY" : 984, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3878, "y" : 978 }, "to" : { "x" : 3850, "y" : 978 } }, { "from" : { "x" : 3850, "y" : 978 }, "to" : { "x" : 3825, "y" : 978 } } ], "endShape" : { "a" : { "x" : 3832, "y" : 974 }, "b" : { "x" : 3825, "y" : 978 }, "c" : { "x" : 3832, "y" : 982 }, "type" : "ARROW", "centre" : { "x" : 3832, "y" : 982 } }, "reactionShape" : { "c" : { "x" : 3850, "y" : 978 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3850, "y" : 978 } }, "inputs" : [ { "id" : 31331, "points" : [ { "x" : 3899, "y" : 978 } ] }, { "id" : 31290, "points" : [ { "x" : 4057, "y" : 539 }, { "x" : 3862, "y" : 775 } ] } ], "outputs" : [ { "id" : 31332 } ] }, { "id" : 31266, "reactomeId" : 10849920, "displayName" : "L1 binds to AP-2 Clathrin complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2200, "y" : 185 }, "minX" : 2119, "maxX" : 2255, "minY" : 179, "maxY" : 208, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2119, "y" : 193 }, "to" : { "x" : 2200, "y" : 185 } }, { "from" : { "x" : 2200, "y" : 185 }, "to" : { "x" : 2255, "y" : 208 } } ], "endShape" : { "a" : { "x" : 2247, "y" : 209 }, "b" : { "x" : 2255, "y" : 208 }, "c" : { "x" : 2250, "y" : 202 }, "type" : "ARROW", "centre" : { "x" : 2250, "y" : 202 } }, "reactionShape" : { "c" : { "x" : 2200, "y" : 185 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2200, "y" : 185 } }, "inputs" : [ { "id" : 31267, "points" : [ { "x" : 2139, "y" : 205 } ] }, { "id" : 31268, "points" : [ { "x" : 2065, "y" : 212 } ] } ], "outputs" : [ { "id" : 31269 } ] }, { "id" : 31299, "reactomeId" : 10847637, "displayName" : "L1 interaction with Integrins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3708, "y" : 227 }, "minX" : 3684, "maxX" : 3743, "minY" : 221, "maxY" : 233, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3684, "y" : 227 }, "to" : { "x" : 3708, "y" : 227 } }, { "from" : { "x" : 3708, "y" : 227 }, "to" : { "x" : 3743, "y" : 227 } } ], "endShape" : { "a" : { "x" : 3736, "y" : 231 }, "b" : { "x" : 3743, "y" : 227 }, "c" : { "x" : 3736, "y" : 223 }, "type" : "ARROW", "centre" : { "x" : 3736, "y" : 223 } }, "reactionShape" : { "c" : { "x" : 3708, "y" : 227 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3708, "y" : 227 } }, "inputs" : [ { "id" : 31300, "points" : [ { "x" : 3667, "y" : 227 } ] }, { "id" : 31290, "points" : [ { "x" : 4050, "y" : 511 }, { "x" : 3699, "y" : 273 } ] } ], "outputs" : [ { "id" : 31301 } ] }, { "id" : 31333, "reactomeId" : 10853368, "displayName" : "Trans-homodimerization of Neurofascin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 602, "y" : 966 }, "minX" : 575, "maxX" : 625, "minY" : 960, "maxY" : 972, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 575, "y" : 966 }, "to" : { "x" : 602, "y" : 966 } }, { "from" : { "x" : 602, "y" : 966 }, "to" : { "x" : 625, "y" : 966 } } ], "endShape" : { "a" : { "x" : 618, "y" : 970 }, "b" : { "x" : 625, "y" : 966 }, "c" : { "x" : 618, "y" : 962 }, "type" : "ARROW", "centre" : { "x" : 618, "y" : 962 } }, "reactionShape" : { "c" : { "x" : 602, "y" : 966 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 602, "y" : 966 } }, "inputs" : [ { "id" : 31334, "points" : [ { "x" : 551, "y" : 966 } ] }, { "id" : 31335, "points" : [ { "x" : 589, "y" : 1115 } ] } ], "outputs" : [ { "id" : 31336 } ] }, { "id" : 31270, "reactomeId" : 10856577, "displayName" : "Formation of clathrin coated vesicle", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2293, "y" : 363 }, "minX" : 2287, "maxX" : 2299, "minY" : 320, "maxY" : 404, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2293, "y" : 320 }, "to" : { "x" : 2293, "y" : 363 } }, { "from" : { "x" : 2293, "y" : 363 }, "to" : { "x" : 2293, "y" : 404 } } ], "reactionShape" : { "a" : { "x" : 2287, "y" : 357 }, "b" : { "x" : 2299, "y" : 369 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2293, "y" : 363 } }, "inputs" : [ { "id" : 31271, "points" : [ { "x" : 2261, "y" : 315 } ] }, { "id" : 31272, "points" : [ { "x" : 2427, "y" : 238 } ] }, { "id" : 31269, "points" : [ { "x" : 2293, "y" : 250 } ] } ], "outputs" : [ { "id" : 31273, "points" : [ { "x" : 2262, "y" : 406 } ] }, { "id" : 31274, "points" : [ { "x" : 2293, "y" : 526 } ] }, { "id" : 31275, "points" : [ { "x" : 2328, "y" : 411 } ] } ], "catalysts" : [ { "id" : 31276, "points" : [ { "x" : 2532, "y" : 242 }, { "x" : 2362, "y" : 363 } ] } ] }, { "id" : 31302, "reactomeId" : 10853580, "displayName" : "Activation of Rac1 by VAV2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2950, "y" : 579 }, "minX" : 2915, "maxX" : 2986, "minY" : 573, "maxY" : 585, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2986, "y" : 579 }, "to" : { "x" : 2950, "y" : 579 } }, { "from" : { "x" : 2950, "y" : 579 }, "to" : { "x" : 2915, "y" : 579 } } ], "reactionShape" : { "a" : { "x" : 2944, "y" : 573 }, "b" : { "x" : 2956, "y" : 585 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2950, "y" : 579 } }, "inputs" : [ { "id" : 31303, "points" : [ { "x" : 3014, "y" : 596 } ] }, { "id" : 31304, "points" : [ { "x" : 3013, "y" : 560 } ] } ], "outputs" : [ { "id" : 31305, "points" : [ { "x" : 2879, "y" : 549 } ] }, { "id" : 31306, "points" : [ { "x" : 2883, "y" : 603 } ] } ], "catalysts" : [ { "id" : 31307, "points" : [ { "x" : 2949, "y" : 663 } ] } ] }, { "id" : 31337, "reactomeId" : 10847388, "displayName" : "Neurofascin interacts with syntenin-1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 35, "y" : 860 }, "minX" : 29, "maxX" : 66, "minY" : 808, "maxY" : 874, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 35, "y" : 808 }, "to" : { "x" : 35, "y" : 860 } }, { "from" : { "x" : 35, "y" : 860 }, "to" : { "x" : 66, "y" : 874 } } ], "endShape" : { "a" : { "x" : 58, "y" : 875 }, "b" : { "x" : 66, "y" : 874 }, "c" : { "x" : 61, "y" : 868 }, "type" : "ARROW", "centre" : { "x" : 61, "y" : 868 } }, "reactionShape" : { "c" : { "x" : 35, "y" : 860 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 35, "y" : 860 } }, "inputs" : [ { "id" : 31338, "points" : [ { "x" : 61, "y" : 814 } ] }, { "id" : 31339, "points" : [ { "x" : 78, "y" : 779 } ] } ], "outputs" : [ { "id" : 31340 } ] }, { "id" : 31308, "reactomeId" : 10853686, "displayName" : "Interaction of PAK1 with Rac1-GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2908, "y" : 477 }, "minX" : 2868, "maxX" : 2950, "minY" : 471, "maxY" : 483, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2868, "y" : 477 }, "to" : { "x" : 2908, "y" : 477 } }, { "from" : { "x" : 2908, "y" : 477 }, "to" : { "x" : 2950, "y" : 477 } } ], "reactionShape" : { "a" : { "x" : 2902, "y" : 471 }, "b" : { "x" : 2914, "y" : 483 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2908, "y" : 477 } }, "inputs" : [ { "id" : 31305, "points" : [ { "x" : 2868, "y" : 521 } ] }, { "id" : 31309, "points" : [ { "x" : 2828, "y" : 448 } ], "stoichiometry" : 2 }, { "id" : 31310, "points" : [ { "x" : 2835, "y" : 477 } ] } ], "outputs" : [ { "id" : 31311, "points" : [ { "x" : 2913, "y" : 421 } ] }, { "id" : 31312, "points" : [ { "x" : 2972, "y" : 428 } ], "stoichiometry" : 2 }, { "id" : 31313, "points" : [ { "x" : 2992, "y" : 477 } ] } ], "catalysts" : [ { "id" : 31311, "points" : [ { "x" : 2907, "y" : 421 } ] } ] }, { "id" : 31277, "reactomeId" : 10849924, "displayName" : "Transport of L1 into endosomes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2184, "y" : 547 }, "minX" : 2126, "maxX" : 2237, "minY" : 541, "maxY" : 553, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2237, "y" : 547 }, "to" : { "x" : 2184, "y" : 547 } }, { "from" : { "x" : 2184, "y" : 547 }, "to" : { "x" : 2126, "y" : 547 } } ], "reactionShape" : { "a" : { "x" : 2178, "y" : 541 }, "b" : { "x" : 2190, "y" : 553 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2184, "y" : 547 } }, "inputs" : [ { "id" : 31274 } ] }, { "id" : 31341, "reactomeId" : 10847377, "displayName" : "Neurofascin and NrCAM heterodimerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 6, "y" : 862 }, "minX" : 0, "maxX" : 84, "minY" : 765, "maxY" : 949, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 6, "y" : 765 }, "to" : { "x" : 6, "y" : 862 } }, { "from" : { "x" : 6, "y" : 862 }, "to" : { "x" : 84, "y" : 949 } } ], "endShape" : { "a" : { "x" : 76, "y" : 947 }, "b" : { "x" : 84, "y" : 949 }, "c" : { "x" : 82, "y" : 941 }, "type" : "ARROW", "centre" : { "x" : 82, "y" : 941 } }, "reactionShape" : { "c" : { "x" : 6, "y" : 862 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 6, "y" : 862 } }, "inputs" : [ { "id" : 31342, "points" : [ { "x" : 67, "y" : 392 }, { "x" : 6, "y" : 404 } ] }, { "id" : 31339, "points" : [ { "x" : 53, "y" : 765 } ] } ], "outputs" : [ { "id" : 31343 } ] }, { "id" : 31278, "reactomeId" : 10853732, "displayName" : "Phosphorylation of L1 by ERK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1933, "y" : 511 }, "minX" : 1898, "maxX" : 1972, "minY" : 505, "maxY" : 517, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1972, "y" : 511 }, "to" : { "x" : 1933, "y" : 511 } }, { "from" : { "x" : 1933, "y" : 511 }, "to" : { "x" : 1898, "y" : 511 } } ], "reactionShape" : { "a" : { "x" : 1927, "y" : 505 }, "b" : { "x" : 1939, "y" : 517 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1933, "y" : 511 } }, "inputs" : [ { "id" : 31279, "points" : [ { "x" : 2020, "y" : 526 } ] }, { "id" : 31280, "points" : [ { "x" : 1947, "y" : 431 } ] }, { "id" : 31281, "points" : [ { "x" : 2003, "y" : 456 } ] } ], "outputs" : [ { "id" : 31282, "points" : [ { "x" : 1869, "y" : 453 } ] }, { "id" : 31283, "points" : [ { "x" : 1846, "y" : 511 } ] } ], "catalysts" : [ { "id" : 31280, "points" : [ { "x" : 1939, "y" : 431 } ] } ] }, { "id" : 31344, "reactomeId" : 10897487, "displayName" : "LYPLA2 hydrolyses PALM-C3,4-GAP43", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1463, "y" : 1006 }, "minX" : 1414, "maxX" : 1515, "minY" : 1000, "maxY" : 1012, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1414, "y" : 1006 }, "to" : { "x" : 1463, "y" : 1006 } }, { "from" : { "x" : 1463, "y" : 1006 }, "to" : { "x" : 1515, "y" : 1006 } } ], "reactionShape" : { "a" : { "x" : 1457, "y" : 1000 }, "b" : { "x" : 1469, "y" : 1012 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1463, "y" : 1006 } }, "inputs" : [ { "id" : 31345, "points" : [ { "x" : 1370, "y" : 1006 } ] }, { "id" : 31346, "points" : [ { "x" : 1376, "y" : 982 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 31347, "points" : [ { "x" : 1576, "y" : 1006 } ] }, { "id" : 31348, "points" : [ { "x" : 1545, "y" : 968 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 31349, "points" : [ { "x" : 1463, "y" : 1046 } ] } ] }, { "id" : 31314, "reactomeId" : 10835985, "displayName" : "MAP2K1 phosphorylates MAPK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3320, "y" : 558 }, "minX" : 3272, "maxX" : 3361, "minY" : 552, "maxY" : 564, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3361, "y" : 558 }, "to" : { "x" : 3320, "y" : 558 } }, { "from" : { "x" : 3320, "y" : 558 }, "to" : { "x" : 3272, "y" : 558 } } ], "reactionShape" : { "a" : { "x" : 3314, "y" : 552 }, "b" : { "x" : 3326, "y" : 564 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3320, "y" : 558 } }, "inputs" : [ { "id" : 31315, "points" : [ { "x" : 3395, "y" : 586 } ], "stoichiometry" : 2 }, { "id" : 31316, "points" : [ { "x" : 3390, "y" : 526 } ] } ], "outputs" : [ { "id" : 31317, "points" : [ { "x" : 3234, "y" : 526 } ] }, { "id" : 31318, "points" : [ { "x" : 3234, "y" : 583 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 31316, "points" : [ { "x" : 3355, "y" : 504 }, { "x" : 3319, "y" : 504 } ] } ], "inhibitors" : [ { "id" : 31319, "points" : [ { "x" : 3320, "y" : 600 } ] } ] }, { "id" : 31284, "reactomeId" : 10849945, "displayName" : "L1 linked to actin cytoskeleton by ankyrin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 685, "y" : 217 }, "minX" : 661, "maxX" : 702, "minY" : 211, "maxY" : 223, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 702, "y" : 217 }, "to" : { "x" : 685, "y" : 217 } }, { "from" : { "x" : 685, "y" : 217 }, "to" : { "x" : 661, "y" : 217 } } ], "endShape" : { "a" : { "x" : 668, "y" : 213 }, "b" : { "x" : 661, "y" : 217 }, "c" : { "x" : 668, "y" : 221 }, "type" : "ARROW", "centre" : { "x" : 668, "y" : 221 } }, "reactionShape" : { "c" : { "x" : 685, "y" : 217 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 685, "y" : 217 } }, "inputs" : [ { "id" : 31285, "points" : [ { "x" : 712, "y" : 217 } ] }, { "id" : 31286, "points" : [ { "x" : 684, "y" : 250 } ] } ], "outputs" : [ { "id" : 31287 } ] }, { "id" : 31288, "reactomeId" : 10847627, "displayName" : "L1 and NCAM1 engaged in cis-interaction", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 4077, "y" : 882 }, "minX" : 4071, "maxX" : 4142, "minY" : 876, "maxY" : 913, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 4142, "y" : 876 }, "to" : { "x" : 4077, "y" : 882 } }, { "from" : { "x" : 4077, "y" : 882 }, "to" : { "x" : 4078, "y" : 913 } } ], "endShape" : { "a" : { "x" : 4074, "y" : 906 }, "b" : { "x" : 4078, "y" : 913 }, "c" : { "x" : 4082, "y" : 906 }, "type" : "ARROW", "centre" : { "x" : 4082, "y" : 906 } }, "reactionShape" : { "c" : { "x" : 4077, "y" : 882 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 4077, "y" : 882 } }, "inputs" : [ { "id" : 31289, "points" : [ { "x" : 4176, "y" : 1114 } ] }, { "id" : 31290, "points" : [ { "x" : 4086, "y" : 539 }, { "x" : 4142, "y" : 567 } ] } ], "outputs" : [ { "id" : 31291 } ] }, { "id" : 31320, "reactomeId" : 10835995, "displayName" : "MAP2K2 phosphorylates MAPK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3316, "y" : 402 }, "minX" : 3271, "maxX" : 3359, "minY" : 396, "maxY" : 408, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3359, "y" : 402 }, "to" : { "x" : 3316, "y" : 402 } }, { "from" : { "x" : 3316, "y" : 402 }, "to" : { "x" : 3271, "y" : 402 } } ], "reactionShape" : { "a" : { "x" : 3310, "y" : 396 }, "b" : { "x" : 3322, "y" : 408 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3316, "y" : 402 } }, "inputs" : [ { "id" : 31321, "points" : [ { "x" : 3390, "y" : 374 } ], "stoichiometry" : 2 }, { "id" : 31322, "points" : [ { "x" : 3388, "y" : 430 } ] } ], "outputs" : [ { "id" : 31323, "points" : [ { "x" : 3235, "y" : 430 } ] }, { "id" : 31324, "points" : [ { "x" : 3233, "y" : 374 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 31322, "points" : [ { "x" : 3354, "y" : 451 }, { "x" : 3316, "y" : 451 } ] } ] }, { "id" : 31259, "reactomeId" : 10847556, "displayName" : "L1 trans-homophilic interaction", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1394, "y" : 226 }, "minX" : 1362, "maxX" : 1419, "minY" : 220, "maxY" : 232, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1419, "y" : 226 }, "to" : { "x" : 1394, "y" : 226 } }, { "from" : { "x" : 1394, "y" : 226 }, "to" : { "x" : 1362, "y" : 226 } } ], "endShape" : { "a" : { "x" : 1369, "y" : 222 }, "b" : { "x" : 1362, "y" : 226 }, "c" : { "x" : 1369, "y" : 230 }, "type" : "ARROW", "centre" : { "x" : 1369, "y" : 230 } }, "reactionShape" : { "c" : { "x" : 1394, "y" : 226 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1394, "y" : 226 } }, "inputs" : [ { "id" : 31260, "points" : [ { "x" : 1446, "y" : 226 } ] }, { "id" : 31261, "points" : [ { "x" : 1419, "y" : 148 } ] } ], "outputs" : [ { "id" : 31262 } ] }, { "id" : 31292, "reactomeId" : 10853168, "displayName" : "L1-FGFR cis-heterodimerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 945, "y" : 137 }, "minX" : 910, "maxX" : 980, "minY" : 131, "maxY" : 143, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 910, "y" : 137 }, "to" : { "x" : 945, "y" : 137 } }, { "from" : { "x" : 945, "y" : 137 }, "to" : { "x" : 980, "y" : 137 } } ], "endShape" : { "a" : { "x" : 973, "y" : 141 }, "b" : { "x" : 980, "y" : 137 }, "c" : { "x" : 973, "y" : 133 }, "type" : "ARROW", "centre" : { "x" : 973, "y" : 133 } }, "reactionShape" : { "c" : { "x" : 945, "y" : 137 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 945, "y" : 137 } }, "inputs" : [ { "id" : 31293, "points" : [ { "x" : 898, "y" : 207 } ] }, { "id" : 31294, "points" : [ { "x" : 884, "y" : 137 } ] } ], "outputs" : [ { "id" : 31295 } ] }, { "id" : 31325, "reactomeId" : 10849966, "displayName" : "Phosphorylation of L1 by CK-II", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2863, "y" : 223 }, "minX" : 2809, "maxX" : 2899, "minY" : 217, "maxY" : 229, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2809, "y" : 223 }, "to" : { "x" : 2863, "y" : 223 } }, { "from" : { "x" : 2863, "y" : 223 }, "to" : { "x" : 2899, "y" : 223 } } ], "reactionShape" : { "a" : { "x" : 2857, "y" : 217 }, "b" : { "x" : 2869, "y" : 229 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2863, "y" : 223 } }, "inputs" : [ { "id" : 31268, "points" : [ { "x" : 2049, "y" : 212 }, { "x" : 2099, "y" : 157 }, { "x" : 2727, "y" : 157 } ] }, { "id" : 31326, "points" : [ { "x" : 2767, "y" : 276 } ] }, { "id" : 31327, "points" : [ { "x" : 2857, "y" : 337 } ] } ], "outputs" : [ { "id" : 31328, "points" : [ { "x" : 2962, "y" : 224 } ] }, { "id" : 31329, "points" : [ { "x" : 2947, "y" : 281 } ] } ], "catalysts" : [ { "id" : 31327, "points" : [ { "x" : 2862, "y" : 337 } ] } ] }, { "id" : 31263, "reactomeId" : 10853372, "displayName" : "Linkage of L1 with treadmilling F-actin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1215, "y" : 226 }, "minX" : 1177, "maxX" : 1241, "minY" : 220, "maxY" : 232, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1241, "y" : 226 }, "to" : { "x" : 1215, "y" : 226 } }, { "from" : { "x" : 1215, "y" : 226 }, "to" : { "x" : 1177, "y" : 226 } } ], "endShape" : { "a" : { "x" : 1184, "y" : 222 }, "b" : { "x" : 1177, "y" : 226 }, "c" : { "x" : 1184, "y" : 230 }, "type" : "ARROW", "centre" : { "x" : 1184, "y" : 230 } }, "reactionShape" : { "c" : { "x" : 1215, "y" : 226 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1215, "y" : 226 } }, "inputs" : [ { "id" : 31264, "points" : [ { "x" : 1285, "y" : 272 } ] }, { "id" : 31262, "points" : [ { "x" : 1268, "y" : 226 } ] } ], "outputs" : [ { "id" : 31265 } ] } ], "compartments" : [ { "id" : 31360, "reactomeId" : 20592, "displayName" : "clathrin-coated endocytic vesicle", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2362, "y" : 527 }, "minX" : 2219, "maxX" : 2506, "minY" : 463, "maxY" : 591, "prop" : { "x" : 2219, "y" : 463, "width" : 287, "height" : 128 }, "textPosition" : { "x" : 2258, "y" : 475 }, "insets" : { "x" : 2229, "y" : 473, "width" : 267, "height" : 108 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31274 ] }, { "id" : 31376, "reactomeId" : 17940, "displayName" : "endosome", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1922, "y" : 547 }, "minX" : 1693, "maxX" : 2151, "minY" : 467, "maxY" : 627, "prop" : { "x" : 1693, "y" : 467, "width" : 458, "height" : 160 }, "textPosition" : { "x" : 2034, "y" : 573 }, "insets" : { "x" : 1703, "y" : 477, "width" : 438, "height" : 140 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31283, 31278, 31279 ] }, { "id" : 31377, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2081, "y" : 644 }, "minX" : 82, "maxX" : 4081, "minY" : 222, "maxY" : 1066, "prop" : { "x" : 82, "y" : 222, "width" : 3999, "height" : 844 }, "textPosition" : { "x" : 2659, "y" : 362 }, "insets" : { "x" : 92, "y" : 232, "width" : 3979, "height" : 824 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31264, 31267, 31269, 31271, 31273, 31275, 31276, 31280, 31281, 31282, 31360, 31293, 31287, 31291, 31290, 31297, 31298, 31300, 31301, 31307, 31303, 31305, 31306, 31304, 31309, 31310, 31311, 31312, 31313, 31315, 31316, 31317, 31318, 31321, 31322, 31323, 31324, 31326, 31327, 31328, 31329, 31331, 31342, 31338, 31340, 31302, 31308, 31314, 31320, 31325, 31330, 31375, 31376, 31319, 31268, 31260, 31262, 31265, 31263, 31259, 31272, 31332, 31343, 31339, 31334, 31336, 31333, 31288, 31299, 31296, 31270, 31277, 31286, 31285, 31344, 31345, 31346, 31347, 31348, 31349 ] }, { "id" : 31378, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2065, "y" : 71 }, "minX" : 36, "maxX" : 4094, "minY" : 0, "maxY" : 142, "prop" : { "x" : 36, "y" : 0, "width" : 4058, "height" : 142 }, "textPosition" : { "x" : 2605, "y" : 49 }, "insets" : { "x" : 46, "y" : 10, "width" : 4038, "height" : 122 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31261, 31294, 31292, 31295 ] }, { "id" : 31384, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2153, "y" : 1180 }, "minX" : 84, "maxX" : 4222, "minY" : 1120, "maxY" : 1240, "prop" : { "x" : 84, "y" : 1120, "width" : 4138, "height" : 120 }, "textPosition" : { "x" : 2123, "y" : 1163 }, "insets" : { "x" : 94, "y" : 1130, "width" : 4118, "height" : 100 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31289, 31335 ] }, { "id" : 31375, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2011, "y" : 708 }, "minX" : 1892, "maxX" : 2130, "minY" : 670, "maxY" : 746, "prop" : { "x" : 1892, "y" : 670, "width" : 238, "height" : 76 }, "textPosition" : { "x" : 2014, "y" : 690 }, "insets" : { "x" : 1902, "y" : 680, "width" : 218, "height" : 56 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 31385, "reactomeId" : 10910952, "displayName" : "Signal transduction by L1", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2512, "y" : 635 }, "minX" : 806, "maxX" : 4218, "minY" : 115, "maxY" : 1155, "prop" : { "x" : 806, "y" : 575, "width" : 3412, "height" : 580 }, "points" : [ { "x" : 806, "y" : 115 }, { "x" : 4218, "y" : 115 }, { "x" : 4218, "y" : 1155 }, { "x" : 806, "y" : 1155 } ], "colour" : "#4684ee" }, { "id" : 31386, "reactomeId" : 10911810, "displayName" : "Neurofascin interactions", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 377, "y" : 758 }, "minX" : -10, "maxX" : 764, "minY" : 367, "maxY" : 1150, "prop" : { "x" : -10, "y" : 367, "width" : 774, "height" : 783 }, "points" : [ { "x" : -10, "y" : 367 }, { "x" : 764, "y" : 367 }, { "x" : 764, "y" : 1150 }, { "x" : -10, "y" : 1150 } ], "colour" : "#dc3912" }, { "id" : 31387, "reactomeId" : 10911824, "displayName" : "Recycling pathway of L1", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1832, "y" : 343 }, "minX" : 1057, "maxX" : 2608, "minY" : 112, "maxY" : 575, "prop" : { "x" : 1057, "y" : 112, "width" : 1551, "height" : 463 }, "points" : [ { "x" : 1057, "y" : 112 }, { "x" : 2608, "y" : 112 }, { "x" : 2608, "y" : 575 }, { "x" : 1057, "y" : 575 } ], "colour" : "#008000" }, { "id" : 31388, "reactomeId" : 10911932, "displayName" : "Interaction between L1 and Ankyrins", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 693, "y" : 237 }, "minX" : 533, "maxX" : 853, "minY" : 189, "maxY" : 285, "prop" : { "x" : 533, "y" : 189, "width" : 273, "height" : 96 }, "points" : [ { "x" : 533, "y" : 189 }, { "x" : 853, "y" : 189 }, { "x" : 853, "y" : 285 }, { "x" : 533, "y" : 285 } ], "colour" : "#666666" } ], "minX" : 0, "maxX" : 4222, "minY" : 0, "maxY" : 1240, "disease" : false }