{ "dbId" : 10910638, "stableId" : "R-DME-5628897", "displayName" : "TP53 Regulates Metabolic Genes", "nodes" : [ { "id" : 86657, "reactomeId" : 10838459, "displayName" : "Cytochrome c oxidase:CO", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 821, "y" : 364 }, "minX" : 736, "maxX" : 873, "minY" : 203, "maxY" : 382, "prop" : { "x" : 776, "y" : 346, "width" : 91, "height" : 36 }, "textPosition" : { "x" : 777, "y" : 347 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 867, "y" : 346 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 867, "y" : 346 } } }, "connectors" : [ { "edgeId" : 86648, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 811, "y" : 343 }, "to" : { "x" : 740, "y" : 205 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 736, "y" : 207 }, "b" : { "x" : 744, "y" : 203 }, "c" : { "x" : 740, "y" : 205 }, "type" : "STOP", "centre" : { "x" : 740, "y" : 205 } } } ] }, { "id" : 86656, "reactomeId" : 10838471, "displayName" : "Homologues of HIGD1C", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 738, "y" : 365 }, "minX" : 713, "maxX" : 763, "minY" : 206, "maxY" : 377, "prop" : { "x" : 713, "y" : 354, "width" : 50, "height" : 23 }, "textPosition" : { "x" : 713, "y" : 327 }, "connectors" : [ { "edgeId" : 86648, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 737, "y" : 351 }, "to" : { "x" : 736, "y" : 206 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 740, "y" : 213 }, "b" : { "x" : 736, "y" : 206 }, "c" : { "x" : 732, "y" : 213 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 732, "y" : 213 } } } ] }, { "id" : 86659, "reactomeId" : 113522, "displayName" : "L-Gln", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 378, "y" : 341 }, "minX" : 357, "maxX" : 401, "minY" : 315, "maxY" : 355, "prop" : { "x" : 357, "y" : 328, "width" : 43, "height" : 27 }, "textPosition" : { "x" : 359, "y" : 331 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 395, "y" : 333 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 395, "y" : 333 } } }, "connectors" : [ { "edgeId" : 86658, "type" : "INPUT", "segments" : [ { "from" : { "x" : 387, "y" : 325 }, "to" : { "x" : 396, "y" : 315 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86661, "reactomeId" : 113552, "displayName" : "L-Glu", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 316, "y" : 232 }, "minX" : 295, "maxX" : 394, "minY" : 218, "maxY" : 264, "prop" : { "x" : 295, "y" : 219, "width" : 42, "height" : 27 }, "textPosition" : { "x" : 297, "y" : 222 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 332, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 332, "y" : 224 } } }, "connectors" : [ { "edgeId" : 86658, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 340, "y" : 240 }, "to" : { "x" : 394, "y" : 264 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 348, "y" : 239 }, "b" : { "x" : 340, "y" : 240 }, "c" : { "x" : 345, "y" : 246 }, "type" : "ARROW", "centre" : { "x" : 345, "y" : 246 } } } ] }, { "id" : 86660, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 432, "y" : 334 }, "minX" : 396, "maxX" : 451, "minY" : 315, "maxY" : 348, "prop" : { "x" : 414, "y" : 320, "width" : 36, "height" : 28 }, "textPosition" : { "x" : 415, "y" : 323 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 445, "y" : 325 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 445, "y" : 325 } } }, "connectors" : [ { "edgeId" : 86658, "type" : "INPUT", "segments" : [ { "from" : { "x" : 411, "y" : 324 }, "to" : { "x" : 396, "y" : 315 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86663, "reactomeId" : 10831014, "displayName" : "GLS dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 308, "y" : 295 }, "minX" : 269, "maxX" : 389, "minY" : 284, "maxY" : 306, "prop" : { "x" : 269, "y" : 284, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 269, "y" : 284 }, "connectors" : [ { "edgeId" : 86658, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 353, "y" : 295 }, "to" : { "x" : 381, "y" : 295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 385, "y" : 295 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 385, "y" : 295 } } } ] }, { "id" : 86662, "reactomeId" : 113561, "displayName" : "NH4+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 407, "y" : 231 }, "minX" : 384, "maxX" : 431, "minY" : 218, "maxY" : 264, "prop" : { "x" : 384, "y" : 219, "width" : 46, "height" : 25 }, "textPosition" : { "x" : 385, "y" : 221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 425, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 425, "y" : 224 } } }, "connectors" : [ { "edgeId" : 86658, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 402, "y" : 247 }, "to" : { "x" : 394, "y" : 264 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 403, "y" : 255 }, "b" : { "x" : 402, "y" : 247 }, "c" : { "x" : 395, "y" : 252 }, "type" : "ARROW", "centre" : { "x" : 395, "y" : 252 } } } ] }, { "id" : 86671, "reactomeId" : 10910746, "displayName" : "Detoxification of Reactive Oxygen Species", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1466, "y" : 1076 }, "minX" : 1378, "maxX" : 1554, "minY" : 1038, "maxY" : 1114, "prop" : { "x" : 1378, "y" : 1038, "width" : 176, "height" : 76 }, "textPosition" : { "x" : 1377, "y" : 1054 }, "connectors" : [ ] }, { "id" : 86670, "reactomeId" : 10910612, "displayName" : "Metabolism of carbohydrates and carbohydrate derivatives", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1506, "y" : 594 }, "minX" : 1443, "maxX" : 1569, "minY" : 565, "maxY" : 624, "prop" : { "x" : 1443, "y" : 565, "width" : 126, "height" : 59 }, "textPosition" : { "x" : 1450, "y" : 552 }, "connectors" : [ ] }, { "id" : 86672, "reactomeId" : 111745, "displayName" : "GSSG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1262, "y" : 1045 }, "minX" : 1236, "maxX" : 1290, "minY" : 1029, "maxY" : 1060, "prop" : { "x" : 1236, "y" : 1030, "width" : 53, "height" : 30 }, "textPosition" : { "x" : 1241, "y" : 1034 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1284, "y" : 1035 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1284, "y" : 1035 } } }, "connectors" : [ ] }, { "id" : 86675, "reactomeId" : 10911848, "displayName" : "Energy dependent regulation of mTOR by LKB1-AMPK", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 437, "y" : 1415 }, "minX" : 352, "maxX" : 522, "minY" : 1385, "maxY" : 1446, "prop" : { "x" : 352, "y" : 1385, "width" : 170, "height" : 61 }, "textPosition" : { "x" : 358, "y" : 1387 }, "connectors" : [ ] }, { "id" : 86674, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1342, "y" : 1203 }, "minX" : 1320, "maxX" : 1366, "minY" : 1185, "maxY" : 1221, "prop" : { "x" : 1320, "y" : 1186, "width" : 45, "height" : 35 }, "textPosition" : { "x" : 1325, "y" : 1193 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1360, "y" : 1191 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1360, "y" : 1191 } } }, "connectors" : [ ] }, { "id" : 86679, "reactomeId" : 10836373, "displayName" : "RRM2B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 951, "y" : 1011 }, "minX" : 926, "maxX" : 982, "minY" : 994, "maxY" : 1022, "prop" : { "x" : 926, "y" : 1000, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 926, "y" : 1000 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 976, "y" : 1000 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 976, "y" : 1000 } } }, "connectors" : [ ] }, { "id" : 86681, "reactomeId" : 10831012, "displayName" : "GLS2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 307, "y" : 337 }, "minX" : 268, "maxX" : 353, "minY" : 320, "maxY" : 348, "prop" : { "x" : 268, "y" : 326, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 268, "y" : 327 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 347, "y" : 326 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 347, "y" : 326 } } }, "connectors" : [ ] }, { "id" : 86680, "reactomeId" : 10910732, "displayName" : "Metabolism of nucleotides", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 951, "y" : 1085 }, "minX" : 886, "maxX" : 1016, "minY" : 1059, "maxY" : 1111, "prop" : { "x" : 886, "y" : 1059, "width" : 130, "height" : 52 }, "textPosition" : { "x" : 897, "y" : 1063 }, "connectors" : [ ] }, { "id" : 86682, "reactomeId" : 10910648, "displayName" : "Metabolism of amino acids and derivatives", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 318, "y" : 112 }, "minX" : 237, "maxX" : 400, "minY" : 78, "maxY" : 147, "prop" : { "x" : 237, "y" : 78, "width" : 163, "height" : 69 }, "textPosition" : { "x" : 244, "y" : 91 }, "connectors" : [ ] }, { "id" : 86684, "reactomeId" : 10911582, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 75, "y" : 1125 }, "minX" : 7, "maxX" : 144, "minY" : 1095, "maxY" : 1155, "prop" : { "x" : 7, "y" : 1095, "width" : 137, "height" : 60 }, "textPosition" : { "x" : 8, "y" : 1103 }, "connectors" : [ ] }, { "id" : 86686, "reactomeId" : 10843241, "displayName" : "Pten", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 97, "y" : 1019 }, "minX" : 77, "maxX" : 123, "minY" : 1002, "maxY" : 1030, "prop" : { "x" : 77, "y" : 1008, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 78, "y" : 1008 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 117, "y" : 1008 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 117, "y" : 1008 } } }, "connectors" : [ ] }, { "id" : 86595, "reactomeId" : 29512, "displayName" : "Fru(6)P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1369, "y" : 592 }, "minX" : 1336, "maxX" : 1404, "minY" : 574, "maxY" : 609, "prop" : { "x" : 1336, "y" : 575, "width" : 67, "height" : 34 }, "textPosition" : { "x" : 1342, "y" : 581 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1398, "y" : 580 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1398, "y" : 580 } } }, "connectors" : [ { "edgeId" : 86594, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86597, "reactomeId" : 10830777, "displayName" : "GPI dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1244, "y" : 688 }, "minX" : 1203, "maxX" : 1359, "minY" : 666, "maxY" : 704, "prop" : { "x" : 1203, "y" : 672, "width" : 82, "height" : 32 }, "textPosition" : { "x" : 1210, "y" : 683 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1285, "y" : 672 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1285, "y" : 672 } } }, "connectors" : [ { "edgeId" : 86594, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1288, "y" : 688 }, "to" : { "x" : 1351, "y" : 688 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1355, "y" : 688 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1355, "y" : 688 } } } ] }, { "id" : 86596, "reactomeId" : 30537, "displayName" : "G6P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1369, "y" : 766 }, "minX" : 1347, "maxX" : 1392, "minY" : 751, "maxY" : 832, "prop" : { "x" : 1347, "y" : 752, "width" : 44, "height" : 29 }, "textPosition" : { "x" : 1352, "y" : 756 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1386, "y" : 757 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1386, "y" : 757 } } }, "connectors" : [ { "edgeId" : 86594, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86598, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1369, "y" : 784 }, "to" : { "x" : 1371, "y" : 832 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86599, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1211, "y" : 785 }, "minX" : 1180, "maxX" : 1371, "minY" : 769, "maxY" : 832, "prop" : { "x" : 1180, "y" : 770, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 1185, "y" : 774 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1238, "y" : 775 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1238, "y" : 775 } } }, "connectors" : [ { "edgeId" : 86598, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1246, "y" : 794 }, "to" : { "x" : 1371, "y" : 832 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86601, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1261, "y" : 990 }, "minX" : 1230, "maxX" : 1369, "minY" : 907, "maxY" : 1005, "prop" : { "x" : 1230, "y" : 975, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 1236, "y" : 979 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1288, "y" : 980 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1288, "y" : 980 } } }, "connectors" : [ { "edgeId" : 86598, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1280, "y" : 972 }, "to" : { "x" : 1369, "y" : 907 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1283, "y" : 965 }, "b" : { "x" : 1280, "y" : 972 }, "c" : { "x" : 1288, "y" : 971 }, "type" : "ARROW", "centre" : { "x" : 1288, "y" : 971 } } } ] }, { "id" : 86600, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1252, "y" : 918 }, "minX" : 1231, "maxX" : 1369, "minY" : 901, "maxY" : 935, "prop" : { "x" : 1231, "y" : 902, "width" : 42, "height" : 33 }, "textPosition" : { "x" : 1238, "y" : 908 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1268, "y" : 907 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1268, "y" : 907 } } }, "connectors" : [ { "edgeId" : 86598, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1276, "y" : 916 }, "to" : { "x" : 1369, "y" : 907 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1283, "y" : 911 }, "b" : { "x" : 1276, "y" : 916 }, "c" : { "x" : 1283, "y" : 919 }, "type" : "ARROW", "centre" : { "x" : 1283, "y" : 919 } } } ], "trivial" : true }, { "id" : 86603, "reactomeId" : 10830662, "displayName" : "G6PD dimer and tetramer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1277, "y" : 865 }, "minX" : 1221, "maxX" : 1363, "minY" : 848, "maxY" : 883, "prop" : { "x" : 1221, "y" : 848, "width" : 113, "height" : 35 }, "textPosition" : { "x" : 1221, "y" : 848 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 86598, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1340, "y" : 863 }, "to" : { "x" : 1355, "y" : 863 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1359, "y" : 863 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1359, "y" : 863 } } } ] }, { "id" : 86602, "reactomeId" : 31467, "displayName" : "D-Glucono-1,5-lactone 6-phosphate", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1508, "y" : 980 }, "minX" : 1369, "maxX" : 1580, "minY" : 907, "maxY" : 1012, "prop" : { "x" : 1438, "y" : 949, "width" : 141, "height" : 63 }, "textPosition" : { "x" : 1439, "y" : 963 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1574, "y" : 954 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1574, "y" : 954 } } }, "connectors" : [ { "edgeId" : 86598, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1448, "y" : 946 }, "to" : { "x" : 1369, "y" : 907 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1440, "y" : 947 }, "b" : { "x" : 1448, "y" : 946 }, "c" : { "x" : 1444, "y" : 939 }, "type" : "ARROW", "centre" : { "x" : 1444, "y" : 939 } } } ] }, { "id" : 86605, "reactomeId" : 10833019, "displayName" : "Trx2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 924, "y" : 1351 }, "minX" : 906, "maxX" : 949, "minY" : 1320, "maxY" : 1457, "prop" : { "x" : 906, "y" : 1340, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 907, "y" : 1340 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 943, "y" : 1340 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 943, "y" : 1340 } } }, "connectors" : [ { "edgeId" : 86604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 919, "y" : 1337 }, "to" : { "x" : 912, "y" : 1320 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86610, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 923, "y" : 1365 }, "to" : { "x" : 921, "y" : 1457 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 927, "y" : 1372 }, "b" : { "x" : 923, "y" : 1365 }, "c" : { "x" : 919, "y" : 1372 }, "type" : "ARROW", "centre" : { "x" : 919, "y" : 1372 } } } ] }, { "id" : 86607, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 813, "y" : 1372 }, "minX" : 788, "maxX" : 851, "minY" : 1318, "maxY" : 1385, "prop" : { "x" : 788, "y" : 1360, "width" : 50, "height" : 25 }, "textPosition" : { "x" : 796, "y" : 1362 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 833, "y" : 1365 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 833, "y" : 1365 } } }, "connectors" : [ { "edgeId" : 86604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 821, "y" : 1357 }, "to" : { "x" : 851, "y" : 1318 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 830, "y" : 1331 }, "b" : { "x" : 842, "y" : 1343 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 836, "y" : 1337 } } }, "endShape" : { "a" : { "x" : 822, "y" : 1349 }, "b" : { "x" : 821, "y" : 1357 }, "c" : { "x" : 828, "y" : 1354 }, "type" : "ARROW", "centre" : { "x" : 828, "y" : 1354 } } } ], "trivial" : true }, { "id" : 86606, "reactomeId" : 29408, "displayName" : "H2O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1016, "y" : 1347 }, "minX" : 912, "maxX" : 1044, "minY" : 1204, "maxY" : 1362, "prop" : { "x" : 989, "y" : 1332, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 995, "y" : 1336 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1038, "y" : 1337 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1038, "y" : 1337 } } }, "connectors" : [ { "edgeId" : 86604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 986, "y" : 1339 }, "to" : { "x" : 912, "y" : 1320 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86615, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1011, "y" : 1329 }, "to" : { "x" : 975, "y" : 1204 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 987, "y" : 1260 }, "b" : { "x" : 999, "y" : 1272 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 993, "y" : 1266 } } } } ] }, { "id" : 86609, "reactomeId" : 10873699, "displayName" : "PRDX1,2,5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 872, "y" : 1261 }, "minX" : 831, "maxX" : 914, "minY" : 1250, "maxY" : 1310, "prop" : { "x" : 831, "y" : 1250, "width" : 83, "height" : 22 }, "textPosition" : { "x" : 836, "y" : 1250 }, "connectors" : [ { "edgeId" : 86604, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 872, "y" : 1278 }, "to" : { "x" : 872, "y" : 1302 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 872, "y" : 1306 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 872, "y" : 1306 } } } ] }, { "id" : 86608, "reactomeId" : 10833017, "displayName" : "Trx2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 733, "y" : 1343 }, "minX" : 691, "maxX" : 851, "minY" : 1318, "maxY" : 1456, "prop" : { "x" : 691, "y" : 1328, "width" : 84, "height" : 30 }, "textPosition" : { "x" : 716, "y" : 1332 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 775, "y" : 1328 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 775, "y" : 1328 } } }, "connectors" : [ { "edgeId" : 86604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 778, "y" : 1334 }, "to" : { "x" : 851, "y" : 1318 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 784, "y" : 1329 }, "b" : { "x" : 778, "y" : 1334 }, "c" : { "x" : 786, "y" : 1336 }, "type" : "ARROW", "centre" : { "x" : 786, "y" : 1336 } } }, { "edgeId" : 86610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 736, "y" : 1361 }, "to" : { "x" : 761, "y" : 1456 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86611, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 707, "y" : 1486 }, "minX" : 686, "maxX" : 761, "minY" : 1456, "maxY" : 1503, "prop" : { "x" : 686, "y" : 1470, "width" : 42, "height" : 33 }, "textPosition" : { "x" : 693, "y" : 1476 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 723, "y" : 1475 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 723, "y" : 1475 } } }, "connectors" : [ { "edgeId" : 86610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 731, "y" : 1474 }, "to" : { "x" : 761, "y" : 1456 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86613, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 983, "y" : 1474 }, "minX" : 921, "maxX" : 1016, "minY" : 1457, "maxY" : 1489, "prop" : { "x" : 952, "y" : 1459, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 957, "y" : 1463 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1010, "y" : 1464 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1010, "y" : 1464 } } }, "connectors" : [ { "edgeId" : 86610, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 949, "y" : 1465 }, "to" : { "x" : 921, "y" : 1457 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 941, "y" : 1467 }, "b" : { "x" : 949, "y" : 1465 }, "c" : { "x" : 943, "y" : 1459 }, "type" : "ARROW", "centre" : { "x" : 943, "y" : 1459 } } } ] }, { "id" : 86612, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 701, "y" : 1425 }, "minX" : 670, "maxX" : 761, "minY" : 1409, "maxY" : 1456, "prop" : { "x" : 670, "y" : 1410, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 676, "y" : 1414 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 728, "y" : 1415 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 728, "y" : 1415 } } }, "connectors" : [ { "edgeId" : 86610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 730, "y" : 1443 }, "to" : { "x" : 761, "y" : 1456 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86614, "reactomeId" : 10833033, "displayName" : "TNXRD1:FAD dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 861, "y" : 1503 }, "minX" : 801, "maxX" : 928, "minY" : 1465, "maxY" : 1521, "prop" : { "x" : 801, "y" : 1486, "width" : 121, "height" : 35 }, "textPosition" : { "x" : 817, "y" : 1486 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 922, "y" : 1486 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 922, "y" : 1486 } } }, "connectors" : [ { "edgeId" : 86610, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 861, "y" : 1483 }, "to" : { "x" : 862, "y" : 1473 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 862, "y" : 1469 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 862, "y" : 1469 } } } ] }, { "id" : 86617, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 752, "y" : 1196 }, "minX" : 731, "maxX" : 793, "minY" : 1152, "maxY" : 1211, "prop" : { "x" : 731, "y" : 1181, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 735, "y" : 1185 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 769, "y" : 1186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 769, "y" : 1186 } } }, "connectors" : [ { "edgeId" : 86615, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 765, "y" : 1178 }, "to" : { "x" : 793, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 767, "y" : 1170 }, "b" : { "x" : 765, "y" : 1178 }, "c" : { "x" : 773, "y" : 1176 }, "type" : "ARROW", "centre" : { "x" : 773, "y" : 1176 } } } ], "trivial" : true }, { "id" : 86616, "reactomeId" : 10873684, "displayName" : "PRDX1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 871, "y" : 1203 }, "minX" : 828, "maxX" : 975, "minY" : 1160, "maxY" : 1214, "prop" : { "x" : 828, "y" : 1192, "width" : 87, "height" : 22 }, "textPosition" : { "x" : 828, "y" : 1193 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 915, "y" : 1192 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 915, "y" : 1192 } } }, "connectors" : [ { "edgeId" : 86615, "type" : "INPUT", "segments" : [ { "from" : { "x" : 918, "y" : 1203 }, "to" : { "x" : 975, "y" : 1204 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86615, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 871, "y" : 1189 }, "to" : { "x" : 872, "y" : 1168 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 872, "y" : 1164 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 872, "y" : 1164 } } } ] }, { "id" : 86618, "reactomeId" : 10879705, "displayName" : "HOOS-C52-PRDX1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 742, "y" : 1121 }, "minX" : 680, "maxX" : 810, "minY" : 1073, "maxY" : 1152, "prop" : { "x" : 680, "y" : 1103, "width" : 124, "height" : 36 }, "textPosition" : { "x" : 682, "y" : 1104 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 804, "y" : 1103 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 804, "y" : 1103 } } }, "connectors" : [ { "edgeId" : 86615, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 771, "y" : 1142 }, "to" : { "x" : 793, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 779, "y" : 1141 }, "b" : { "x" : 771, "y" : 1142 }, "c" : { "x" : 776, "y" : 1149 }, "type" : "ARROW", "centre" : { "x" : 776, "y" : 1149 } } }, { "edgeId" : 86619, "type" : "INPUT", "segments" : [ { "from" : { "x" : 739, "y" : 1100 }, "to" : { "x" : 735, "y" : 1073 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86621, "reactomeId" : 10879719, "displayName" : "SESN1,2,3:HOOS-C52-PRDX1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 600, "y" : 1105 }, "minX" : 554, "maxX" : 653, "minY" : 1073, "maxY" : 1131, "prop" : { "x" : 554, "y" : 1079, "width" : 93, "height" : 52 }, "textPosition" : { "x" : 557, "y" : 1082 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 647, "y" : 1079 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 647, "y" : 1079 } } }, "connectors" : [ { "edgeId" : 86619, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86620, "reactomeId" : 10879713, "displayName" : "Sesn", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 774, "y" : 994 }, "minX" : 447, "maxX" : 825, "minY" : 978, "maxY" : 1095, "prop" : { "x" : 730, "y" : 984, "width" : 89, "height" : 21 }, "textPosition" : { "x" : 755, "y" : 984 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 819, "y" : 984 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 819, "y" : 984 } } }, "connectors" : [ { "edgeId" : 86632, "type" : "INPUT", "segments" : [ { "from" : { "x" : 740, "y" : 1011 }, "to" : { "x" : 447, "y" : 1095 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86619, "type" : "INPUT", "segments" : [ { "from" : { "x" : 768, "y" : 1011 }, "to" : { "x" : 735, "y" : 1073 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86623, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 96, "y" : 1474 }, "minX" : 29, "maxX" : 119, "minY" : 1460, "maxY" : 1487, "prop" : { "x" : 75, "y" : 1461, "width" : 43, "height" : 26 }, "textPosition" : { "x" : 81, "y" : 1463 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 113, "y" : 1466 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 113, "y" : 1466 } } }, "connectors" : [ { "edgeId" : 86622, "type" : "INPUT", "segments" : [ { "from" : { "x" : 72, "y" : 1475 }, "to" : { "x" : 29, "y" : 1478 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86625, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 95, "y" : 1542 }, "minX" : 28, "maxX" : 116, "minY" : 1529, "maxY" : 1555, "prop" : { "x" : 75, "y" : 1530, "width" : 40, "height" : 25 }, "textPosition" : { "x" : 78, "y" : 1532 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 110, "y" : 1535 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 110, "y" : 1535 } } }, "connectors" : [ { "edgeId" : 86622, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 72, "y" : 1538 }, "to" : { "x" : 28, "y" : 1529 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 64, "y" : 1541 }, "b" : { "x" : 72, "y" : 1538 }, "c" : { "x" : 66, "y" : 1533 }, "type" : "ARROW", "centre" : { "x" : 66, "y" : 1533 } } } ] }, { "id" : 86624, "reactomeId" : 10839183, "displayName" : "TSC1:TSC2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 31, "y" : 1433 }, "minX" : 8, "maxX" : 61, "minY" : 1409, "maxY" : 1478, "prop" : { "x" : 8, "y" : 1415, "width" : 47, "height" : 37 }, "textPosition" : { "x" : 10, "y" : 1417 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 55, "y" : 1415 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 55, "y" : 1415 } } }, "connectors" : [ { "edgeId" : 86640, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86622, "type" : "INPUT", "segments" : [ { "from" : { "x" : 30, "y" : 1455 }, "to" : { "x" : 29, "y" : 1478 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86627, "reactomeId" : 10848809, "displayName" : "p-AMPK heterotrimer:AMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 437, "y" : 1285 }, "minX" : 37, "maxX" : 502, "minY" : 1095, "maxY" : 1507, "prop" : { "x" : 378, "y" : 1266, "width" : 118, "height" : 38 }, "textPosition" : { "x" : 378, "y" : 1269 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 496, "y" : 1266 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 496, "y" : 1266 } } }, "connectors" : [ { "edgeId" : 86632, "type" : "INPUT", "segments" : [ { "from" : { "x" : 438, "y" : 1263 }, "to" : { "x" : 447, "y" : 1095 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86622, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 417, "y" : 1307 }, "to" : { "x" : 213, "y" : 1500 } }, { "from" : { "x" : 213, "y" : 1500 }, "to" : { "x" : 45, "y" : 1503 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 41, "y" : 1503 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 41, "y" : 1503 } } } ] }, { "id" : 86626, "reactomeId" : 10848807, "displayName" : "TSC1:p-S1387-TSC2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 52, "y" : 1603 }, "minX" : 0, "maxX" : 362, "minY" : 1529, "maxY" : 1622, "prop" : { "x" : 0, "y" : 1584, "width" : 105, "height" : 38 }, "textPosition" : { "x" : 3, "y" : 1587 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 105, "y" : 1584 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 105, "y" : 1584 } } }, "connectors" : [ { "edgeId" : 86628, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 108, "y" : 1602 }, "to" : { "x" : 358, "y" : 1602 } }, { "from" : { "x" : 358, "y" : 1602 }, "to" : { "x" : 358, "y" : 1577 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 362, "y" : 1584 }, "b" : { "x" : 358, "y" : 1577 }, "c" : { "x" : 354, "y" : 1584 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 354, "y" : 1584 } } }, { "edgeId" : 86622, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 45, "y" : 1581 }, "to" : { "x" : 28, "y" : 1529 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 39, "y" : 1576 }, "b" : { "x" : 45, "y" : 1581 }, "c" : { "x" : 47, "y" : 1573 }, "type" : "ARROW", "centre" : { "x" : 47, "y" : 1573 } } } ] }, { "id" : 86629, "reactomeId" : 10839281, "displayName" : "Active mTORC1 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 260, "y" : 1571 }, "minX" : 193, "maxX" : 362, "minY" : 1538, "maxY" : 1589, "prop" : { "x" : 193, "y" : 1553, "width" : 135, "height" : 36 }, "textPosition" : { "x" : 208, "y" : 1554 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 328, "y" : 1553 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 328, "y" : 1553 } } }, "connectors" : [ { "edgeId" : 86628, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86628, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 312, "y" : 1550 }, "to" : { "x" : 357, "y" : 1538 } }, { "from" : { "x" : 357, "y" : 1538 }, "to" : { "x" : 357, "y" : 1552 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 358, "y" : 1556 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 358, "y" : 1556 } } } ] }, { "id" : 86631, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 432, "y" : 1614 }, "minX" : 383, "maxX" : 448, "minY" : 1569, "maxY" : 1627, "prop" : { "x" : 417, "y" : 1602, "width" : 30, "height" : 25 }, "textPosition" : { "x" : 422, "y" : 1604 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 442, "y" : 1607 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 442, "y" : 1607 } } }, "connectors" : [ { "edgeId" : 86628, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 418, "y" : 1599 }, "to" : { "x" : 383, "y" : 1569 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 410, "y" : 1598 }, "b" : { "x" : 418, "y" : 1599 }, "c" : { "x" : 415, "y" : 1591 }, "type" : "ARROW", "centre" : { "x" : 415, "y" : 1591 } } } ] }, { "id" : 86630, "reactomeId" : 10848826, "displayName" : "mTORC1:Ragulator:Rag:GNP:RHEB:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 518, "y" : 1572 }, "minX" : 383, "maxX" : 589, "minY" : 1548, "maxY" : 1590, "prop" : { "x" : 453, "y" : 1554, "width" : 130, "height" : 36 }, "textPosition" : { "x" : 453, "y" : 1555 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 583, "y" : 1554 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 583, "y" : 1554 } } }, "connectors" : [ { "edgeId" : 86628, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 450, "y" : 1570 }, "to" : { "x" : 383, "y" : 1569 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 443, "y" : 1574 }, "b" : { "x" : 450, "y" : 1570 }, "c" : { "x" : 443, "y" : 1566 }, "type" : "ARROW", "centre" : { "x" : 443, "y" : 1566 } } } ] }, { "id" : 86633, "reactomeId" : 10879723, "displayName" : "SESN1,2,3:p-AMPK heterotrimer:AMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 598, "y" : 1200 }, "minX" : 535, "maxX" : 667, "minY" : 1176, "maxY" : 1219, "prop" : { "x" : 535, "y" : 1182, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 535, "y" : 1184 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 661, "y" : 1182 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 661, "y" : 1182 } } }, "connectors" : [ { "edgeId" : 86632, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86635, "reactomeId" : 10839158, "displayName" : "gig", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 119, "y" : 1382 }, "minX" : 31, "maxX" : 211, "minY" : 1341, "maxY" : 1393, "prop" : { "x" : 100, "y" : 1371, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 106, "y" : 1371 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 139, "y" : 1371 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 139, "y" : 1371 } } }, "connectors" : [ { "edgeId" : 86634, "type" : "INPUT", "segments" : [ { "from" : { "x" : 142, "y" : 1373 }, "to" : { "x" : 211, "y" : 1341 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86640, "type" : "INPUT", "segments" : [ { "from" : { "x" : 97, "y" : 1382 }, "to" : { "x" : 31, "y" : 1386 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86637, "reactomeId" : 10842910, "displayName" : "phospho-gig", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 216, "y" : 1219 }, "minX" : 162, "maxX" : 276, "minY" : 1167, "maxY" : 1274, "prop" : { "x" : 162, "y" : 1201, "width" : 108, "height" : 37 }, "textPosition" : { "x" : 173, "y" : 1209 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 270, "y" : 1201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 270, "y" : 1201 } } }, "connectors" : [ { "edgeId" : 86634, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 214, "y" : 1241 }, "to" : { "x" : 213, "y" : 1274 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 218, "y" : 1248 }, "b" : { "x" : 214, "y" : 1241 }, "c" : { "x" : 210, "y" : 1248 }, "type" : "ARROW", "centre" : { "x" : 210, "y" : 1248 } } }, { "edgeId" : 86642, "type" : "INPUT", "segments" : [ { "from" : { "x" : 216, "y" : 1198 }, "to" : { "x" : 218, "y" : 1167 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86636, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 262, "y" : 1346 }, "minX" : 211, "maxX" : 284, "minY" : 1332, "maxY" : 1359, "prop" : { "x" : 242, "y" : 1333, "width" : 41, "height" : 26 }, "textPosition" : { "x" : 247, "y" : 1335 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 278, "y" : 1338 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 278, "y" : 1338 } } }, "connectors" : [ { "edgeId" : 86634, "type" : "INPUT", "segments" : [ { "from" : { "x" : 239, "y" : 1343 }, "to" : { "x" : 211, "y" : 1341 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 219, "y" : 1336 }, "b" : { "x" : 231, "y" : 1348 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 225, "y" : 1342 } } } } ] }, { "id" : 86639, "reactomeId" : 10842912, "displayName" : "p-T,p-S-AKT", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 121, "y" : 1308 }, "minX" : 77, "maxX" : 206, "minY" : 1297, "maxY" : 1319, "prop" : { "x" : 77, "y" : 1297, "width" : 88, "height" : 22 }, "textPosition" : { "x" : 82, "y" : 1297 }, "connectors" : [ { "edgeId" : 86634, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 171, "y" : 1306 }, "to" : { "x" : 198, "y" : 1305 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 202, "y" : 1305 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 202, "y" : 1305 } } } ] }, { "id" : 86638, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 270, "y" : 1270 }, "minX" : 213, "maxX" : 292, "minY" : 1256, "maxY" : 1283, "prop" : { "x" : 249, "y" : 1257, "width" : 42, "height" : 26 }, "textPosition" : { "x" : 253, "y" : 1259 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 286, "y" : 1262 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 286, "y" : 1262 } } }, "connectors" : [ { "edgeId" : 86634, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 246, "y" : 1271 }, "to" : { "x" : 213, "y" : 1274 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 223, "y" : 1266 }, "b" : { "x" : 235, "y" : 1278 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 229, "y" : 1272 } } }, "endShape" : { "a" : { "x" : 239, "y" : 1276 }, "b" : { "x" : 246, "y" : 1271 }, "c" : { "x" : 239, "y" : 1268 }, "type" : "ARROW", "centre" : { "x" : 239, "y" : 1268 } } } ] }, { "id" : 86641, "reactomeId" : 10839179, "displayName" : "Tsc1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 28, "y" : 1350 }, "minX" : 9, "maxX" : 54, "minY" : 1333, "maxY" : 1386, "prop" : { "x" : 9, "y" : 1339, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 10, "y" : 1339 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 48, "y" : 1339 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 48, "y" : 1339 } } }, "connectors" : [ { "edgeId" : 86640, "type" : "INPUT", "segments" : [ { "from" : { "x" : 28, "y" : 1364 }, "to" : { "x" : 31, "y" : 1386 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86643, "reactomeId" : 10834080, "displayName" : "14-3-3 dimer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 220, "y" : 1114 }, "minX" : 174, "maxX" : 267, "minY" : 1075, "maxY" : 1167, "prop" : { "x" : 174, "y" : 1103, "width" : 93, "height" : 22 }, "textPosition" : { "x" : 177, "y" : 1103 }, "connectors" : [ { "edgeId" : 86642, "type" : "INPUT", "segments" : [ { "from" : { "x" : 219, "y" : 1131 }, "to" : { "x" : 218, "y" : 1167 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86646, "type" : "INPUT", "segments" : [ { "from" : { "x" : 223, "y" : 1097 }, "to" : { "x" : 234, "y" : 1075 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86645, "reactomeId" : 10879766, "displayName" : "DDIT4:14-3-3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 239, "y" : 1022 }, "minX" : 151, "maxX" : 295, "minY" : 998, "maxY" : 1171, "prop" : { "x" : 189, "y" : 1004, "width" : 100, "height" : 36 }, "textPosition" : { "x" : 193, "y" : 1005 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 289, "y" : 1004 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 289, "y" : 1004 } } }, "connectors" : [ { "edgeId" : 86642, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 186, "y" : 1023 }, "to" : { "x" : 153, "y" : 1024 } }, { "from" : { "x" : 153, "y" : 1024 }, "to" : { "x" : 151, "y" : 1170 } }, { "from" : { "x" : 151, "y" : 1170 }, "to" : { "x" : 209, "y" : 1167 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 209, "y" : 1163 }, "b" : { "x" : 209, "y" : 1171 }, "c" : { "x" : 209, "y" : 1167 }, "type" : "STOP", "centre" : { "x" : 209, "y" : 1167 } } }, { "edgeId" : 86646, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86644, "reactomeId" : 10879752, "displayName" : "p-S939,T1462-TSC2:14-3-3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 321, "y" : 1156 }, "minX" : 252, "maxX" : 397, "minY" : 1132, "maxY" : 1174, "prop" : { "x" : 252, "y" : 1138, "width" : 139, "height" : 36 }, "textPosition" : { "x" : 254, "y" : 1139 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 391, "y" : 1138 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 391, "y" : 1138 } } }, "connectors" : [ { "edgeId" : 86642, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86647, "reactomeId" : 10879764, "displayName" : "Homologues of DDIT4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 359, "y" : 1077 }, "minX" : 234, "maxX" : 382, "minY" : 1066, "maxY" : 1088, "prop" : { "x" : 336, "y" : 1066, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 337, "y" : 1046 }, "connectors" : [ { "edgeId" : 86646, "type" : "INPUT", "segments" : [ { "from" : { "x" : 333, "y" : 1076 }, "to" : { "x" : 234, "y" : 1075 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86649, "reactomeId" : 10838298, "displayName" : "Homologues of Cytochrome c (reduced)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 585, "y" : 195 }, "minX" : 542, "maxX" : 716, "minY" : 177, "maxY" : 222, "prop" : { "x" : 542, "y" : 177, "width" : 87, "height" : 37 }, "textPosition" : { "x" : 541, "y" : 164 }, "connectors" : [ { "edgeId" : 86648, "type" : "INPUT", "segments" : [ { "from" : { "x" : 632, "y" : 203 }, "to" : { "x" : 716, "y" : 222 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 668, "y" : 206 }, "b" : { "x" : 680, "y" : 218 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 674, "y" : 212 } } } } ] }, { "id" : 86651, "reactomeId" : 113529, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 686, "y" : 265 }, "minX" : 668, "maxX" : 716, "minY" : 222, "maxY" : 280, "prop" : { "x" : 668, "y" : 250, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 672, "y" : 254 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 699, "y" : 255 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 699, "y" : 255 } } }, "connectors" : [ { "edgeId" : 86648, "type" : "INPUT", "segments" : [ { "from" : { "x" : 696, "y" : 247 }, "to" : { "x" : 716, "y" : 222 } } ], "stoichiometry" : { "value" : 12, "shape" : { "a" : { "x" : 700, "y" : 228 }, "b" : { "x" : 712, "y" : 240 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 706, "y" : 234 } } } } ], "trivial" : true }, { "id" : 86650, "reactomeId" : 113533, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 645, "y" : 240 }, "minX" : 628, "maxX" : 716, "minY" : 222, "maxY" : 255, "prop" : { "x" : 628, "y" : 225, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 632, "y" : 229 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 657, "y" : 230 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 657, "y" : 230 } } }, "connectors" : [ { "edgeId" : 86648, "type" : "INPUT", "segments" : [ { "from" : { "x" : 665, "y" : 235 }, "to" : { "x" : 716, "y" : 222 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86653, "reactomeId" : 10838308, "displayName" : "Homologues of Cytochrome c (oxidised)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 900, "y" : 200 }, "minX" : 775, "maxX" : 944, "minY" : 182, "maxY" : 219, "prop" : { "x" : 857, "y" : 182, "width" : 87, "height" : 37 }, "textPosition" : { "x" : 856, "y" : 169 }, "connectors" : [ { "edgeId" : 86648, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 854, "y" : 198 }, "to" : { "x" : 775, "y" : 197 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 808, "y" : 191 }, "b" : { "x" : 820, "y" : 203 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 814, "y" : 197 } } }, "endShape" : { "a" : { "x" : 847, "y" : 202 }, "b" : { "x" : 854, "y" : 198 }, "c" : { "x" : 847, "y" : 194 }, "type" : "ARROW", "centre" : { "x" : 847, "y" : 194 } } } ] }, { "id" : 86652, "reactomeId" : 163953, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 839, "y" : 145 }, "minX" : 775, "maxX" : 858, "minY" : 129, "maxY" : 197, "prop" : { "x" : 821, "y" : 130, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 825, "y" : 134 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 852, "y" : 135 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 852, "y" : 135 } } }, "connectors" : [ { "edgeId" : 86648, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 818, "y" : 159 }, "to" : { "x" : 775, "y" : 197 } } ], "stoichiometry" : { "value" : 8, "shape" : { "a" : { "x" : 790, "y" : 172 }, "b" : { "x" : 802, "y" : 184 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 796, "y" : 178 } } }, "endShape" : { "a" : { "x" : 815, "y" : 167 }, "b" : { "x" : 818, "y" : 159 }, "c" : { "x" : 810, "y" : 161 }, "type" : "ARROW", "centre" : { "x" : 810, "y" : 161 } } } ], "trivial" : true }, { "id" : 86655, "reactomeId" : 10838456, "displayName" : "Cytochrome c oxidase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 486, "y" : 192 }, "minX" : 441, "maxX" : 728, "minY" : 148, "maxY" : 210, "prop" : { "x" : 441, "y" : 174, "width" : 91, "height" : 36 }, "textPosition" : { "x" : 443, "y" : 175 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 532, "y" : 174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 532, "y" : 174 } } }, "connectors" : [ { "edgeId" : 86648, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 495, "y" : 171 }, "to" : { "x" : 509, "y" : 148 } }, { "from" : { "x" : 509, "y" : 148 }, "to" : { "x" : 720, "y" : 194 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 724, "y" : 194 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 724, "y" : 194 } } } ] }, { "id" : 86654, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 812, "y" : 250 }, "minX" : 775, "maxX" : 835, "minY" : 197, "maxY" : 265, "prop" : { "x" : 791, "y" : 235, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 795, "y" : 239 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 829, "y" : 240 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 829, "y" : 240 } } }, "connectors" : [ { "edgeId" : 86648, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 801, "y" : 232 }, "to" : { "x" : 775, "y" : 197 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 782, "y" : 208 }, "b" : { "x" : 794, "y" : 220 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 788, "y" : 214 } } }, "endShape" : { "a" : { "x" : 794, "y" : 229 }, "b" : { "x" : 801, "y" : 232 }, "c" : { "x" : 800, "y" : 224 }, "type" : "ARROW", "centre" : { "x" : 800, "y" : 224 } } } ], "trivial" : true } ], "edges" : [ { "id" : 86658, "reactomeId" : 10831017, "displayName" : "glutamine + H2O => glutamate + NH4+ (GLS)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 397, "y" : 295 }, "minX" : 391, "maxX" : 403, "minY" : 264, "maxY" : 315, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 396, "y" : 315 }, "to" : { "x" : 397, "y" : 295 } }, { "from" : { "x" : 397, "y" : 295 }, "to" : { "x" : 394, "y" : 264 } } ], "reactionShape" : { "a" : { "x" : 391, "y" : 289 }, "b" : { "x" : 403, "y" : 301 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 397, "y" : 295 } }, "inputs" : [ { "id" : 86659, "points" : [ { "x" : 387, "y" : 325 } ] }, { "id" : 86660, "points" : [ { "x" : 411, "y" : 324 } ] } ], "outputs" : [ { "id" : 86661, "points" : [ { "x" : 340, "y" : 240 } ] }, { "id" : 86662, "points" : [ { "x" : 402, "y" : 247 } ] } ], "catalysts" : [ { "id" : 86663, "points" : [ { "x" : 353, "y" : 295 } ] } ] }, { "id" : 86594, "reactomeId" : 10830782, "displayName" : "GPI dimer isomerizes Fru(6)P to G6P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1367, "y" : 688 }, "minX" : 1361, "maxX" : 1373, "minY" : 612, "maxY" : 749, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1368, "y" : 612 }, "to" : { "x" : 1367, "y" : 688 } }, { "from" : { "x" : 1367, "y" : 688 }, "to" : { "x" : 1368, "y" : 749 } } ], "endShape" : { "a" : { "x" : 1364, "y" : 742 }, "b" : { "x" : 1368, "y" : 749 }, "c" : { "x" : 1372, "y" : 742 }, "type" : "ARROW", "centre" : { "x" : 1372, "y" : 742 } }, "reactionShape" : { "a" : { "x" : 1361, "y" : 682 }, "b" : { "x" : 1373, "y" : 694 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1367, "y" : 688 } }, "inputs" : [ { "id" : 86595 } ], "outputs" : [ { "id" : 86596 } ], "catalysts" : [ { "id" : 86597, "points" : [ { "x" : 1288, "y" : 688 } ] } ] }, { "id" : 86628, "reactomeId" : 10848829, "displayName" : "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 358, "y" : 1568 }, "minX" : 331, "maxX" : 383, "minY" : 1562, "maxY" : 1574, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 331, "y" : 1568 }, "to" : { "x" : 358, "y" : 1568 } }, { "from" : { "x" : 358, "y" : 1568 }, "to" : { "x" : 383, "y" : 1569 } } ], "reactionShape" : { "a" : { "x" : 352, "y" : 1562 }, "b" : { "x" : 364, "y" : 1574 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 358, "y" : 1568 } }, "inputs" : [ { "id" : 86629 } ], "outputs" : [ { "id" : 86630, "points" : [ { "x" : 450, "y" : 1570 } ] }, { "id" : 86631, "points" : [ { "x" : 418, "y" : 1599 } ] } ], "catalysts" : [ { "id" : 86629, "points" : [ { "x" : 312, "y" : 1550 }, { "x" : 357, "y" : 1538 } ] } ], "activators" : [ { "id" : 86626, "points" : [ { "x" : 108, "y" : 1602 }, { "x" : 358, "y" : 1602 } ] } ] }, { "id" : 86598, "reactomeId" : 10830665, "displayName" : "G6PD multimers dehydrogenate G6P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1371, "y" : 863 }, "minX" : 1365, "maxX" : 1377, "minY" : 832, "maxY" : 907, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1371, "y" : 832 }, "to" : { "x" : 1371, "y" : 863 } }, { "from" : { "x" : 1371, "y" : 863 }, "to" : { "x" : 1369, "y" : 907 } } ], "reactionShape" : { "a" : { "x" : 1365, "y" : 857 }, "b" : { "x" : 1377, "y" : 869 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1371, "y" : 863 } }, "inputs" : [ { "id" : 86596, "points" : [ { "x" : 1369, "y" : 784 } ] }, { "id" : 86599, "points" : [ { "x" : 1246, "y" : 794 } ] } ], "outputs" : [ { "id" : 86600, "points" : [ { "x" : 1276, "y" : 916 } ] }, { "id" : 86601, "points" : [ { "x" : 1280, "y" : 972 } ] }, { "id" : 86602, "points" : [ { "x" : 1448, "y" : 946 } ] } ], "catalysts" : [ { "id" : 86603, "points" : [ { "x" : 1340, "y" : 863 } ] } ] }, { "id" : 86632, "reactomeId" : 10879725, "displayName" : "SESN1,2,3 bind AMPK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 509, "y" : 1137 }, "minX" : 441, "maxX" : 571, "minY" : 1089, "maxY" : 1179, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 447, "y" : 1095 }, "to" : { "x" : 509, "y" : 1137 } }, { "from" : { "x" : 509, "y" : 1137 }, "to" : { "x" : 571, "y" : 1179 } } ], "endShape" : { "a" : { "x" : 563, "y" : 1178 }, "b" : { "x" : 571, "y" : 1179 }, "c" : { "x" : 568, "y" : 1172 }, "type" : "ARROW", "centre" : { "x" : 568, "y" : 1172 } }, "reactionShape" : { "c" : { "x" : 509, "y" : 1137 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 509, "y" : 1137 } }, "inputs" : [ { "id" : 86627, "points" : [ { "x" : 438, "y" : 1263 } ] }, { "id" : 86620, "points" : [ { "x" : 740, "y" : 1011 } ] } ], "outputs" : [ { "id" : 86633 } ] }, { "id" : 86634, "reactomeId" : 10842915, "displayName" : "AKT phosphorylates TSC2, inhibiting it", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 214, "y" : 1305 }, "minX" : 208, "maxX" : 220, "minY" : 1274, "maxY" : 1341, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 211, "y" : 1341 }, "to" : { "x" : 214, "y" : 1305 } }, { "from" : { "x" : 214, "y" : 1305 }, "to" : { "x" : 213, "y" : 1274 } } ], "reactionShape" : { "a" : { "x" : 208, "y" : 1299 }, "b" : { "x" : 220, "y" : 1311 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 214, "y" : 1305 } }, "inputs" : [ { "id" : 86635, "points" : [ { "x" : 142, "y" : 1373 } ] }, { "id" : 86636, "points" : [ { "x" : 239, "y" : 1343 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86637, "points" : [ { "x" : 214, "y" : 1241 } ] }, { "id" : 86638, "points" : [ { "x" : 246, "y" : 1271 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 86639, "points" : [ { "x" : 171, "y" : 1306 } ] } ] }, { "id" : 86604, "reactomeId" : 10873702, "displayName" : "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 872, "y" : 1318 }, "minX" : 851, "maxX" : 912, "minY" : 1312, "maxY" : 1324, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 912, "y" : 1320 }, "to" : { "x" : 872, "y" : 1318 } }, { "from" : { "x" : 872, "y" : 1318 }, "to" : { "x" : 851, "y" : 1318 } } ], "reactionShape" : { "a" : { "x" : 866, "y" : 1312 }, "b" : { "x" : 878, "y" : 1324 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 872, "y" : 1318 } }, "inputs" : [ { "id" : 86605, "points" : [ { "x" : 919, "y" : 1337 } ] }, { "id" : 86606, "points" : [ { "x" : 986, "y" : 1339 } ] } ], "outputs" : [ { "id" : 86607, "points" : [ { "x" : 821, "y" : 1357 } ], "stoichiometry" : 2 }, { "id" : 86608, "points" : [ { "x" : 778, "y" : 1334 } ] } ], "catalysts" : [ { "id" : 86609, "points" : [ { "x" : 872, "y" : 1278 } ] } ] }, { "id" : 86640, "reactomeId" : 10839185, "displayName" : "Formation of TSC1:TSC2 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 31, "y" : 1387 }, "minX" : 25, "maxX" : 37, "minY" : 1381, "maxY" : 1412, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 31, "y" : 1386 }, "to" : { "x" : 31, "y" : 1387 } }, { "from" : { "x" : 31, "y" : 1387 }, "to" : { "x" : 31, "y" : 1412 } } ], "endShape" : { "a" : { "x" : 27, "y" : 1405 }, "b" : { "x" : 31, "y" : 1412 }, "c" : { "x" : 35, "y" : 1405 }, "type" : "ARROW", "centre" : { "x" : 35, "y" : 1405 } }, "reactionShape" : { "c" : { "x" : 31, "y" : 1387 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 31, "y" : 1387 } }, "inputs" : [ { "id" : 86635, "points" : [ { "x" : 97, "y" : 1382 } ] }, { "id" : 86641, "points" : [ { "x" : 28, "y" : 1364 } ] } ], "outputs" : [ { "id" : 86624 } ] }, { "id" : 86610, "reactomeId" : 10833036, "displayName" : "Regeneration of active (reduced) Thioredoxin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 863, "y" : 1457 }, "minX" : 761, "maxX" : 921, "minY" : 1451, "maxY" : 1463, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 761, "y" : 1456 }, "to" : { "x" : 863, "y" : 1457 } }, { "from" : { "x" : 863, "y" : 1457 }, "to" : { "x" : 921, "y" : 1457 } } ], "reactionShape" : { "a" : { "x" : 857, "y" : 1451 }, "b" : { "x" : 869, "y" : 1463 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 863, "y" : 1457 } }, "inputs" : [ { "id" : 86611, "points" : [ { "x" : 731, "y" : 1474 } ] }, { "id" : 86612, "points" : [ { "x" : 730, "y" : 1443 } ] }, { "id" : 86608, "points" : [ { "x" : 736, "y" : 1361 } ] } ], "outputs" : [ { "id" : 86605, "points" : [ { "x" : 923, "y" : 1365 } ] }, { "id" : 86613, "points" : [ { "x" : 949, "y" : 1465 } ] } ], "catalysts" : [ { "id" : 86614, "points" : [ { "x" : 861, "y" : 1483 } ] } ] }, { "id" : 86642, "reactomeId" : 10879768, "displayName" : "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 218, "y" : 1167 }, "minX" : 212, "maxX" : 249, "minY" : 1161, "maxY" : 1173, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 218, "y" : 1167 }, "to" : { "x" : 220, "y" : 1168 } }, { "from" : { "x" : 220, "y" : 1168 }, "to" : { "x" : 249, "y" : 1164 } } ], "endShape" : { "a" : { "x" : 243, "y" : 1169 }, "b" : { "x" : 249, "y" : 1164 }, "c" : { "x" : 242, "y" : 1161 }, "type" : "ARROW", "centre" : { "x" : 242, "y" : 1161 } }, "reactionShape" : { "c" : { "x" : 218, "y" : 1167 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 218, "y" : 1167 } }, "inputs" : [ { "id" : 86643, "points" : [ { "x" : 219, "y" : 1131 } ] }, { "id" : 86637, "points" : [ { "x" : 216, "y" : 1198 } ] } ], "outputs" : [ { "id" : 86644 } ], "inhibitors" : [ { "id" : 86645, "points" : [ { "x" : 186, "y" : 1023 }, { "x" : 153, "y" : 1024 }, { "x" : 151, "y" : 1170 } ] } ] }, { "id" : 86615, "reactomeId" : 10879708, "displayName" : "PRDX1 overoxidizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 873, "y" : 1152 }, "minX" : 793, "maxX" : 976, "minY" : 1146, "maxY" : 1204, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 975, "y" : 1204 }, "to" : { "x" : 976, "y" : 1153 } }, { "from" : { "x" : 976, "y" : 1153 }, "to" : { "x" : 873, "y" : 1152 } }, { "from" : { "x" : 873, "y" : 1152 }, "to" : { "x" : 793, "y" : 1152 } } ], "reactionShape" : { "a" : { "x" : 867, "y" : 1146 }, "b" : { "x" : 879, "y" : 1158 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 873, "y" : 1152 } }, "inputs" : [ { "id" : 86616, "points" : [ { "x" : 918, "y" : 1203 } ] }, { "id" : 86606, "points" : [ { "x" : 1011, "y" : 1329 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86617, "points" : [ { "x" : 765, "y" : 1178 } ] }, { "id" : 86618, "points" : [ { "x" : 771, "y" : 1142 } ] } ], "catalysts" : [ { "id" : 86616, "points" : [ { "x" : 871, "y" : 1189 } ] } ] }, { "id" : 86646, "reactomeId" : 10879771, "displayName" : "DDIT4 binds 14-3-3 dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 234, "y" : 1074 }, "minX" : 228, "maxX" : 240, "minY" : 1043, "maxY" : 1080, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 234, "y" : 1075 }, "to" : { "x" : 234, "y" : 1074 } }, { "from" : { "x" : 234, "y" : 1074 }, "to" : { "x" : 237, "y" : 1043 } } ], "endShape" : { "a" : { "x" : 240, "y" : 1050 }, "b" : { "x" : 237, "y" : 1043 }, "c" : { "x" : 232, "y" : 1050 }, "type" : "ARROW", "centre" : { "x" : 232, "y" : 1050 } }, "reactionShape" : { "c" : { "x" : 234, "y" : 1074 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 234, "y" : 1074 } }, "inputs" : [ { "id" : 86643, "points" : [ { "x" : 223, "y" : 1097 } ] }, { "id" : 86647, "points" : [ { "x" : 333, "y" : 1076 } ] } ], "outputs" : [ { "id" : 86645 } ] }, { "id" : 86648, "reactomeId" : 10838473, "displayName" : "Electron transfer from reduced cytochrome c to molecular oxygen", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 736, "y" : 197 }, "minX" : 716, "maxX" : 775, "minY" : 191, "maxY" : 222, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 716, "y" : 222 }, "to" : { "x" : 736, "y" : 197 } }, { "from" : { "x" : 736, "y" : 197 }, "to" : { "x" : 775, "y" : 197 } } ], "reactionShape" : { "a" : { "x" : 730, "y" : 191 }, "b" : { "x" : 742, "y" : 203 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 736, "y" : 197 } }, "inputs" : [ { "id" : 86649, "points" : [ { "x" : 632, "y" : 203 } ], "stoichiometry" : 4 }, { "id" : 86650, "points" : [ { "x" : 665, "y" : 235 } ] }, { "id" : 86651, "points" : [ { "x" : 696, "y" : 247 } ], "stoichiometry" : 12 } ], "outputs" : [ { "id" : 86652, "points" : [ { "x" : 818, "y" : 159 } ], "stoichiometry" : 8 }, { "id" : 86653, "points" : [ { "x" : 854, "y" : 198 } ], "stoichiometry" : 4 }, { "id" : 86654, "points" : [ { "x" : 801, "y" : 232 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 86655, "points" : [ { "x" : 495, "y" : 171 }, { "x" : 509, "y" : 148 } ] } ], "inhibitors" : [ { "id" : 86657, "points" : [ { "x" : 811, "y" : 343 } ] } ], "activators" : [ { "id" : 86656, "points" : [ { "x" : 737, "y" : 351 } ] } ] }, { "id" : 86619, "reactomeId" : 10879721, "displayName" : "SESN1,2,3 bind overoxidized PRDX1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 734, "y" : 1073 }, "minX" : 650, "maxX" : 740, "minY" : 1067, "maxY" : 1093, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 735, "y" : 1073 }, "to" : { "x" : 734, "y" : 1073 } }, { "from" : { "x" : 734, "y" : 1073 }, "to" : { "x" : 650, "y" : 1093 } } ], "endShape" : { "a" : { "x" : 656, "y" : 1088 }, "b" : { "x" : 650, "y" : 1093 }, "c" : { "x" : 658, "y" : 1095 }, "type" : "ARROW", "centre" : { "x" : 658, "y" : 1095 } }, "reactionShape" : { "c" : { "x" : 734, "y" : 1073 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 734, "y" : 1073 } }, "inputs" : [ { "id" : 86618, "points" : [ { "x" : 739, "y" : 1100 } ] }, { "id" : 86620, "points" : [ { "x" : 768, "y" : 1011 } ] } ], "outputs" : [ { "id" : 86621 } ] }, { "id" : 86622, "reactomeId" : 10848812, "displayName" : "p-AMPK phosphorylates TSC1:TSC2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 29, "y" : 1503 }, "minX" : 23, "maxX" : 35, "minY" : 1478, "maxY" : 1529, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 29, "y" : 1478 }, "to" : { "x" : 29, "y" : 1503 } }, { "from" : { "x" : 29, "y" : 1503 }, "to" : { "x" : 28, "y" : 1529 } } ], "reactionShape" : { "a" : { "x" : 23, "y" : 1497 }, "b" : { "x" : 35, "y" : 1509 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 29, "y" : 1503 } }, "inputs" : [ { "id" : 86623, "points" : [ { "x" : 72, "y" : 1475 } ] }, { "id" : 86624, "points" : [ { "x" : 30, "y" : 1455 } ] } ], "outputs" : [ { "id" : 86625, "points" : [ { "x" : 72, "y" : 1538 } ] }, { "id" : 86626, "points" : [ { "x" : 45, "y" : 1581 } ] } ], "catalysts" : [ { "id" : 86627, "points" : [ { "x" : 417, "y" : 1307 }, { "x" : 213, "y" : 1500 } ] } ] } ], "compartments" : [ { "id" : 86677, "reactomeId" : 17927, "displayName" : "mitochondrial intermembrane space", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 681, "y" : 255 }, "minX" : 196, "maxX" : 1167, "minY" : 103, "maxY" : 407, "prop" : { "x" : 196, "y" : 103, "width" : 971, "height" : 304 }, "textPosition" : { "x" : 916, "y" : 353 }, "insets" : { "x" : 206, "y" : 113, "width" : 951, "height" : 284 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86676, 86652, 86682, 86697 ] }, { "id" : 86676, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 576, "y" : 285 }, "minX" : 232, "maxX" : 921, "minY" : 193, "maxY" : 377, "prop" : { "x" : 232, "y" : 193, "width" : 689, "height" : 184 }, "textPosition" : { "x" : 450, "y" : 225 }, "insets" : { "x" : 242, "y" : 203, "width" : 669, "height" : 164 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86651, 86655, 86648, 86650, 86654, 86681, 86696, 86658, 86663, 86662, 86661, 86659, 86660, 86657, 86656, 86649, 86653 ] }, { "id" : 86667, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 659, "y" : 711 }, "minX" : 194, "maxX" : 1125, "minY" : 452, "maxY" : 970, "prop" : { "x" : 194, "y" : 452, "width" : 931, "height" : 518 }, "textPosition" : { "x" : 626, "y" : 916 }, "insets" : { "x" : 204, "y" : 462, "width" : 911, "height" : 498 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86665, 86694, 86695 ] }, { "id" : 86666, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 872, "y" : 833 }, "minX" : 16, "maxX" : 1728, "minY" : 0, "maxY" : 1666, "prop" : { "x" : 16, "y" : 0, "width" : 1712, "height" : 1666 }, "textPosition" : { "x" : 549, "y" : 1599 }, "insets" : { "x" : 26, "y" : 10, "width" : 1692, "height" : 1646 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86595, 86667, 86670, 86687, 86594, 86596, 86597, 86598, 86602, 86601, 86599, 86603, 86600, 86688, 86671, 86672, 86674, 86606, 86689, 86690, 86691, 86620, 86604, 86605, 86607, 86609, 86610, 86614, 86613, 86611, 86612, 86615, 86616, 86692, 86618, 86617, 86619, 86621, 86622, 86623, 86624, 86625, 86626, 86627, 86675, 86693, 86632, 86633, 86647, 86636, 86637, 86639, 86634, 86635, 86640, 86641, 86642, 86643, 86644, 86646, 86645, 86638, 86677, 86684, 86698, 86685, 86631, 86680, 86679, 86686, 86699, 86608 ] }, { "id" : 86685, "reactomeId" : 161320, "displayName" : "lysosomal lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 391, "y" : 1537 }, "minX" : 238, "maxX" : 544, "minY" : 1489, "maxY" : 1586, "prop" : { "x" : 238, "y" : 1489, "width" : 306, "height" : 97 }, "textPosition" : { "x" : 270, "y" : 1506 }, "insets" : { "x" : 248, "y" : 1499, "width" : 286, "height" : 77 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86629, 86630, 86628 ] } ], "notes" : [ ], "links" : [ { "id" : 86689, "renderableClass" : "Interaction", "position" : { "x" : 1431, "y" : 688 }, "minX" : 1380, "maxX" : 1482, "minY" : 627, "maxY" : 749, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1482, "y" : 627 }, "to" : { "x" : 1380, "y" : 749 } } ], "endShape" : { "a" : { "x" : 1381, "y" : 741 }, "b" : { "x" : 1380, "y" : 749 }, "c" : { "x" : 1388, "y" : 746 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1388, "y" : 746 } }, "reactionShape" : { "a" : { "x" : 1425, "y" : 682 }, "b" : { "x" : 1437, "y" : 694 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1431, "y" : 688 } }, "inputs" : [ { "id" : 86670 } ], "outputs" : [ { "id" : 86596 } ] }, { "id" : 86688, "renderableClass" : "Interaction", "position" : { "x" : 1506, "y" : 786 }, "minX" : 1500, "maxX" : 1512, "minY" : 627, "maxY" : 946, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1507, "y" : 946 }, "to" : { "x" : 1506, "y" : 627 } } ], "endShape" : { "a" : { "x" : 1510, "y" : 634 }, "b" : { "x" : 1506, "y" : 627 }, "c" : { "x" : 1502, "y" : 634 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1502, "y" : 634 } }, "reactionShape" : { "a" : { "x" : 1500, "y" : 780 }, "b" : { "x" : 1512, "y" : 792 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1506, "y" : 786 } }, "inputs" : [ { "id" : 86602 } ], "outputs" : [ { "id" : 86670 } ] }, { "id" : 86691, "renderableClass" : "Interaction", "position" : { "x" : 1393, "y" : 1150 }, "minX" : 1359, "maxX" : 1428, "minY" : 1117, "maxY" : 1183, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1359, "y" : 1183 }, "to" : { "x" : 1428, "y" : 1117 } } ], "endShape" : { "a" : { "x" : 1426, "y" : 1125 }, "b" : { "x" : 1428, "y" : 1117 }, "c" : { "x" : 1420, "y" : 1119 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1420, "y" : 1119 } }, "reactionShape" : { "a" : { "x" : 1387, "y" : 1144 }, "b" : { "x" : 1399, "y" : 1156 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1393, "y" : 1150 } }, "inputs" : [ { "id" : 86674 } ], "outputs" : [ { "id" : 86671 } ] }, { "id" : 86690, "renderableClass" : "Interaction", "position" : { "x" : 1333, "y" : 1054 }, "minX" : 1292, "maxX" : 1375, "minY" : 1048, "maxY" : 1061, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1375, "y" : 1061 }, "to" : { "x" : 1292, "y" : 1048 } } ], "endShape" : { "a" : { "x" : 1299, "y" : 1045 }, "b" : { "x" : 1292, "y" : 1048 }, "c" : { "x" : 1298, "y" : 1053 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1298, "y" : 1053 } }, "reactionShape" : { "a" : { "x" : 1327, "y" : 1048 }, "b" : { "x" : 1339, "y" : 1060 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1333, "y" : 1054 } }, "inputs" : [ { "id" : 86671 } ], "outputs" : [ { "id" : 86672 } ] }, { "id" : 86693, "renderableClass" : "Interaction", "position" : { "x" : 437, "y" : 1344 }, "minX" : 431, "maxX" : 443, "minY" : 1307, "maxY" : 1382, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 437, "y" : 1382 }, "to" : { "x" : 437, "y" : 1307 } } ], "endShape" : { "a" : { "x" : 441, "y" : 1314 }, "b" : { "x" : 437, "y" : 1307 }, "c" : { "x" : 433, "y" : 1314 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 433, "y" : 1314 } }, "reactionShape" : { "a" : { "x" : 431, "y" : 1338 }, "b" : { "x" : 443, "y" : 1350 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 437, "y" : 1344 } }, "inputs" : [ { "id" : 86675 } ], "outputs" : [ { "id" : 86627 } ] }, { "id" : 86692, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 871, "y" : 1230 }, "minX" : 865, "maxX" : 877, "minY" : 1217, "maxY" : 1244, "segments" : [ { "from" : { "x" : 871, "y" : 1217 }, "to" : { "x" : 871, "y" : 1244 } } ], "reactionShape" : { "a" : { "x" : 865, "y" : 1224 }, "b" : { "x" : 877, "y" : 1236 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 871, "y" : 1230 } }, "inputs" : [ { "id" : 86616 } ], "outputs" : [ { "id" : 86609 } ] }, { "id" : 86695, "renderableClass" : "Interaction", "position" : { "x" : 951, "y" : 1040 }, "minX" : 945, "maxX" : 957, "minY" : 1025, "maxY" : 1056, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 951, "y" : 1025 }, "to" : { "x" : 951, "y" : 1056 } } ], "endShape" : { "a" : { "x" : 947, "y" : 1049 }, "b" : { "x" : 951, "y" : 1056 }, "c" : { "x" : 955, "y" : 1049 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 955, "y" : 1049 } }, "reactionShape" : { "a" : { "x" : 945, "y" : 1034 }, "b" : { "x" : 957, "y" : 1046 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 951, "y" : 1040 } }, "inputs" : [ { "id" : 86679 } ], "outputs" : [ { "id" : 86680 } ] }, { "id" : 86697, "renderableClass" : "Interaction", "position" : { "x" : 316, "y" : 183 }, "minX" : 310, "maxX" : 322, "minY" : 150, "maxY" : 216, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 316, "y" : 216 }, "to" : { "x" : 317, "y" : 150 } } ], "endShape" : { "a" : { "x" : 321, "y" : 157 }, "b" : { "x" : 317, "y" : 150 }, "c" : { "x" : 313, "y" : 157 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 313, "y" : 157 } }, "reactionShape" : { "a" : { "x" : 310, "y" : 177 }, "b" : { "x" : 322, "y" : 189 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 316, "y" : 183 } }, "inputs" : [ { "id" : 86661 } ], "outputs" : [ { "id" : 86682 } ] }, { "id" : 86696, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 307, "y" : 317 }, "minX" : 301, "maxX" : 313, "minY" : 311, "maxY" : 323, "segments" : [ { "from" : { "x" : 307, "y" : 323 }, "to" : { "x" : 307, "y" : 312 } } ], "reactionShape" : { "a" : { "x" : 301, "y" : 311 }, "b" : { "x" : 313, "y" : 323 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 307, "y" : 317 } }, "inputs" : [ { "id" : 86681 } ], "outputs" : [ { "id" : 86663 } ] }, { "id" : 86699, "renderableClass" : "Interaction", "position" : { "x" : 87, "y" : 1062 }, "minX" : 81, "maxX" : 94, "minY" : 1033, "maxY" : 1092, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 94, "y" : 1033 }, "to" : { "x" : 81, "y" : 1092 } } ], "endShape" : { "a" : { "x" : 79, "y" : 1084 }, "b" : { "x" : 81, "y" : 1092 }, "c" : { "x" : 86, "y" : 1086 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 86, "y" : 1086 } }, "reactionShape" : { "a" : { "x" : 81, "y" : 1056 }, "b" : { "x" : 93, "y" : 1068 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 87, "y" : 1062 } }, "inputs" : [ { "id" : 86686 } ], "outputs" : [ { "id" : 86684 } ] }, { "id" : 86698, "renderableClass" : "Interaction", "position" : { "x" : 100, "y" : 1224 }, "minX" : 82, "maxX" : 118, "minY" : 1158, "maxY" : 1291, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 82, "y" : 1158 }, "to" : { "x" : 118, "y" : 1291 } } ], "endShape" : { "a" : { "x" : 112, "y" : 1285 }, "b" : { "x" : 118, "y" : 1291 }, "c" : { "x" : 120, "y" : 1283 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 120, "y" : 1283 } }, "reactionShape" : { "a" : { "x" : 94, "y" : 1218 }, "b" : { "x" : 106, "y" : 1230 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 100, "y" : 1224 } }, "inputs" : [ { "id" : 86684 } ], "outputs" : [ { "id" : 86639 } ] }, { "id" : 86687, "renderableClass" : "Interaction", "position" : { "x" : 1423, "y" : 592 }, "minX" : 1406, "maxX" : 1440, "minY" : 586, "maxY" : 598, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1406, "y" : 592 }, "to" : { "x" : 1440, "y" : 592 } } ], "endShape" : { "a" : { "x" : 1433, "y" : 596 }, "b" : { "x" : 1440, "y" : 592 }, "c" : { "x" : 1433, "y" : 588 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1433, "y" : 588 } }, "reactionShape" : { "a" : { "x" : 1417, "y" : 586 }, "b" : { "x" : 1429, "y" : 598 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1423, "y" : 592 } }, "inputs" : [ { "id" : 86595 } ], "outputs" : [ { "id" : 86670 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1728, "minY" : 0, "maxY" : 1666, "disease" : false }