{
  "dbId" : 10828285,
  "stId" : "R-GGA-9006115",
  "speciesName" : "Gallus gallus",
  "nodes" : [ {
    "dbId" : 10739234,
    "stId" : "R-GGA-351141",
    "displayName" : "RAC1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "identifier" : "A0A8V0Z8U4",
    "standardIdentifier" : "uniprot:A0A8V0Z8U4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RAC1" ],
    "parents" : [ 10778137, 10739236 ],
    "children" : [ ]
  }, {
    "dbId" : 10815522,
    "stId" : "R-GGA-9031934",
    "displayName" : "BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103842 ],
    "parents" : [ ],
    "children" : [ 10742943, 10781234 ]
  }, {
    "dbId" : 10739236,
    "stId" : "R-GGA-442641",
    "displayName" : "RAC1:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103850 ],
    "parents" : [ ],
    "children" : [ 29438, 10739234 ]
  }, {
    "dbId" : 10781228,
    "stId" : "R-GGA-167028",
    "displayName" : "BDNF [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "identifier" : "P25429",
    "standardIdentifier" : "uniprot:P25429",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BDNF" ],
    "parents" : [ 10781230 ],
    "children" : [ ]
  }, {
    "dbId" : 10781230,
    "stId" : "R-GGA-9024931",
    "displayName" : "BDNF homodimer [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "parents" : [ 10781232 ],
    "children" : [ 10781228 ]
  }, {
    "dbId" : 10781224,
    "stId" : "R-GGA-9026475",
    "displayName" : "phospho-p-5Y-NTRK2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "identifier" : "A0A8V0YCV8",
    "standardIdentifier" : "uniprot:A0A8V0YCV8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10781234, 10781232 ],
    "children" : [ ]
  }, {
    "dbId" : 10736304,
    "stId" : "R-GGA-74686",
    "displayName" : "GRB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "identifier" : "A0A8V1APV6",
    "standardIdentifier" : "uniprot:A0A8V1APV6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GRB2" ],
    "parents" : [ 10736310 ],
    "children" : [ ]
  }, {
    "dbId" : 10827825,
    "stId" : "R-GGA-5673001",
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "speciesId" : 49591,
    "diagramIds" : [ 103868 ]
  }, {
    "dbId" : 10781232,
    "stId" : "R-GGA-9026474",
    "displayName" : "BDNF:p-5Y-NTRK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "parents" : [ 10781234 ],
    "children" : [ 10781224, 10781230 ]
  }, {
    "dbId" : 10736310,
    "stId" : "R-GGA-109797",
    "displayName" : "GRB2-1:SOS1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103844 ],
    "parents" : [ 10815549 ],
    "children" : [ 10736304, 10736308 ]
  }, {
    "dbId" : 10781234,
    "stId" : "R-GGA-9026465",
    "displayName" : "BDNF:p-5Y-NTRK2 homodimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103857, 103839 ],
    "parents" : [ 10815560, 10815522, 10815547, 10815487 ],
    "children" : [ 10781224, 10781232 ]
  }, {
    "dbId" : 10736308,
    "stId" : "R-GGA-64847",
    "displayName" : "SOS1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "identifier" : "A0A8V0Z7G5",
    "standardIdentifier" : "uniprot:A0A8V0Z7G5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SOS1" ],
    "parents" : [ 10736310 ],
    "children" : [ ]
  }, {
    "dbId" : 10825597,
    "stId" : "R-GGA-1489509",
    "displayName" : "DAG and IP3 signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 49591,
    "diagramIds" : [ 103863 ]
  }, {
    "dbId" : 10815549,
    "stId" : "R-GGA-9032071",
    "displayName" : "BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103846 ],
    "parents" : [ ],
    "children" : [ 10815547, 10736310 ]
  }, {
    "dbId" : 10815487,
    "stId" : "R-GGA-9026576",
    "displayName" : "BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103837 ],
    "parents" : [ ],
    "children" : [ 10781234, 10748673 ]
  }, {
    "dbId" : 10815545,
    "stId" : "R-GGA-162551",
    "displayName" : "phospho-FRS2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "identifier" : "E1C021",
    "standardIdentifier" : "uniprot:E1C021",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FRS2" ],
    "parents" : [ 10815547 ],
    "children" : [ ]
  }, {
    "dbId" : 10815547,
    "stId" : "R-GGA-9031960",
    "displayName" : "BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103845 ],
    "parents" : [ 10815549 ],
    "children" : [ 10815545, 10781234 ]
  }, {
    "dbId" : 10825669,
    "stId" : "R-GGA-1257604",
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 49591,
    "diagramIds" : [ 103876 ]
  }, {
    "dbId" : 10775685,
    "stId" : "R-GGA-1810410",
    "displayName" : "phospho-FYN [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "identifier" : "A0A3Q2U639",
    "standardIdentifier" : "uniprot:A0A3Q2U639",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FYN" ],
    "parents" : [ 10815560 ],
    "children" : [ ]
  }, {
    "dbId" : 10748673,
    "stId" : "R-GGA-167679",
    "displayName" : "phospho-PLCG1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "diagramIds" : [ 103838 ],
    "identifier" : "A0A8V0ZHR0",
    "standardIdentifier" : "uniprot:A0A8V0ZHR0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PLCG1" ],
    "parents" : [ 10815487 ],
    "children" : [ ]
  }, {
    "dbId" : 29420,
    "stId" : "R-ALL-29420",
    "displayName" : "GDP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 103851 ],
    "identifier" : "58189",
    "standardIdentifier" : "chebi:58189",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10778137 ],
    "children" : [ ]
  }, {
    "dbId" : 10815560,
    "stId" : "R-GGA-9032537",
    "displayName" : "BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "parents" : [ 10815562 ],
    "children" : [ 10781234, 10775685 ]
  }, {
    "dbId" : 10815562,
    "stId" : "R-GGA-9032760",
    "displayName" : "BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103852 ],
    "parents" : [ ],
    "children" : [ 10768347, 10815560 ]
  }, {
    "dbId" : 10827413,
    "stId" : "R-GGA-5663213",
    "displayName" : "RHO GTPases Activate WASPs and WAVEs",
    "schemaClass" : "Pathway",
    "speciesId" : 49591,
    "diagramIds" : [ 103888 ]
  }, {
    "dbId" : 10742943,
    "stId" : "R-GGA-190244",
    "displayName" : "FRS2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "diagramIds" : [ 103841 ],
    "identifier" : "E1C021",
    "standardIdentifier" : "uniprot:E1C021",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FRS2" ],
    "parents" : [ 10815522 ],
    "children" : [ ]
  }, {
    "dbId" : 10778137,
    "stId" : "R-GGA-5674631",
    "displayName" : "RAC1:GDP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49591,
    "diagramIds" : [ 103848 ],
    "parents" : [ ],
    "children" : [ 29420, 10739234 ]
  }, {
    "dbId" : 29438,
    "stId" : "R-ALL-29438",
    "displayName" : "GTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 103849 ],
    "identifier" : "37565",
    "standardIdentifier" : "chebi:37565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10739236 ],
    "children" : [ ]
  }, {
    "dbId" : 10768347,
    "stId" : "R-GGA-1012973",
    "displayName" : "DOCK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49591,
    "identifier" : "A0A8V1A7M9",
    "standardIdentifier" : "uniprot:A0A8V1A7M9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DOCK3" ],
    "parents" : [ 10815562 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10815524,
    "stId" : "R-GGA-9028730",
    "displayName" : "Activated NTRK2 binds FRS2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10742943, 10781234 ],
    "outputs" : [ 10815522 ],
    "efs" : [ ],
    "diagramIds" : [ 103840 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10815489,
    "stId" : "R-GGA-9026894",
    "displayName" : "Activated PCLG1 dissociates from NTRK2",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10815487 ],
    "outputs" : [ 10781234, 10748673 ],
    "efs" : [ ],
    "diagramIds" : [ 103836 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10815565,
    "stId" : "R-GGA-9032798",
    "displayName" : "DOCK3 activates RAC1",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 29438, 10778137 ],
    "outputs" : [ 29420, 10739236 ],
    "catalysts" : [ 10815562 ],
    "efs" : [ ],
    "diagramIds" : [ 103847 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10815551,
    "stId" : "R-GGA-9032073",
    "displayName" : "NTRK2-phosphorylated FRS2 binds GRB2",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10815547, 10736310 ],
    "outputs" : [ 10815549 ],
    "efs" : [ ],
    "diagramIds" : [ 103843 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10828293,
    "stId" : "R-GGA-9028731",
    "displayName" : "Activated NTRK2 signals through FRS2 and FRS3",
    "events" : [ 10815524, 10815551 ]
  }, {
    "dbId" : 10828299,
    "stId" : "R-GGA-9032500",
    "displayName" : "Activated NTRK2 signals through FYN",
    "events" : [ 10815565 ]
  }, {
    "dbId" : 10828283,
    "stId" : "R-GGA-9026527",
    "displayName" : "Activated NTRK2 signals through PLCG1",
    "events" : [ 10815489 ]
  }, {
    "dbId" : 10828297,
    "stId" : "R-GGA-9032759",
    "displayName" : "NTRK2 activates RAC1",
    "events" : [ 10815565 ]
  } ]
}