{ "dbId" : 10827627, "stableId" : "R-GGA-4090294", "displayName" : "SUMOylation of intracellular receptors", "nodes" : [ { "id" : 117633, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 608, "y" : 610 }, "minX" : 537, "maxX" : 647, "minY" : 573, "maxY" : 626, "prop" : { "x" : 575, "y" : 594, "width" : 66, "height" : 32 }, "textPosition" : { "x" : 586, "y" : 599 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 641, "y" : 594 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 641, "y" : 594 } } }, "connectors" : [ { "edgeId" : 117629, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 577, "y" : 591 }, "to" : { "x" : 537, "y" : 573 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 569, "y" : 592 }, "b" : { "x" : 577, "y" : 591 }, "c" : { "x" : 572, "y" : 585 }, "type" : "ARROW", "centre" : { "x" : 572, "y" : 585 } } } ] }, { "id" : 117632, "reactomeId" : 10787581, "displayName" : "monoSUMO1-NR5A2:cis-bicyclo(3.3.0)oct-2-ene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 474, "y" : 610 }, "minX" : 396, "maxX" : 558, "minY" : 573, "maxY" : 630, "prop" : { "x" : 396, "y" : 590, "width" : 156, "height" : 40 }, "textPosition" : { "x" : 399, "y" : 581 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 552, "y" : 590 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 552, "y" : 590 } } }, "connectors" : [ { "edgeId" : 117629, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 508, "y" : 587 }, "to" : { "x" : 537, "y" : 573 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 513, "y" : 580 }, "b" : { "x" : 508, "y" : 587 }, "c" : { "x" : 516, "y" : 588 }, "type" : "ARROW", "centre" : { "x" : 516, "y" : 588 } } } ] }, { "id" : 117634, "reactomeId" : 10786745, "displayName" : "PIAS1,2-1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 466, "y" : 548 }, "minX" : 426, "maxX" : 530, "minY" : 534, "maxY" : 563, "prop" : { "x" : 426, "y" : 534, "width" : 81, "height" : 29 }, "textPosition" : { "x" : 433, "y" : 538 }, "connectors" : [ { "edgeId" : 117629, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 513, "y" : 547 }, "to" : { "x" : 522, "y" : 547 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 526, "y" : 547 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 526, "y" : 547 } } } ] }, { "id" : 117637, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 644, "y" : 944 }, "minX" : 577, "maxX" : 717, "minY" : 923, "maxY" : 983, "prop" : { "x" : 577, "y" : 929, "width" : 134, "height" : 31 }, "textPosition" : { "x" : 584, "y" : 939 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 711, "y" : 929 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 711, "y" : 929 } } }, "connectors" : [ { "edgeId" : 117635, "type" : "INPUT", "segments" : [ { "from" : { "x" : 617, "y" : 963 }, "to" : { "x" : 578, "y" : 983 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117636, "reactomeId" : 10753110, "displayName" : "PPARA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 526, "y" : 943 }, "minX" : 493, "maxX" : 578, "minY" : 923, "maxY" : 983, "prop" : { "x" : 493, "y" : 929, "width" : 66, "height" : 29 }, "textPosition" : { "x" : 502, "y" : 933 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 559, "y" : 929 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 559, "y" : 929 } } }, "connectors" : [ { "edgeId" : 117635, "type" : "INPUT", "segments" : [ { "from" : { "x" : 544, "y" : 961 }, "to" : { "x" : 578, "y" : 983 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117639, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 637, "y" : 1094 }, "minX" : 600, "maxX" : 678, "minY" : 1048, "maxY" : 1108, "prop" : { "x" : 603, "y" : 1081, "width" : 69, "height" : 27 }, "textPosition" : { "x" : 615, "y" : 1084 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 672, "y" : 1081 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 672, "y" : 1081 } } }, "connectors" : [ { "edgeId" : 117635, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 626, "y" : 1078 }, "to" : { "x" : 600, "y" : 1048 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 618, "y" : 1075 }, "b" : { "x" : 626, "y" : 1078 }, "c" : { "x" : 624, "y" : 1070 }, "type" : "ARROW", "centre" : { "x" : 624, "y" : 1070 } } } ] }, { "id" : 117638, "reactomeId" : 10786879, "displayName" : "PPARA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 526, "y" : 1098 }, "minX" : 479, "maxX" : 600, "minY" : 1048, "maxY" : 1120, "prop" : { "x" : 479, "y" : 1077, "width" : 95, "height" : 43 }, "textPosition" : { "x" : 502, "y" : 1088 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 574, "y" : 1077 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 574, "y" : 1077 } } }, "connectors" : [ { "edgeId" : 117635, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 557, "y" : 1074 }, "to" : { "x" : 600, "y" : 1048 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 561, "y" : 1067 }, "b" : { "x" : 557, "y" : 1074 }, "c" : { "x" : 565, "y" : 1074 }, "type" : "ARROW", "centre" : { "x" : 565, "y" : 1074 } } } ] }, { "id" : 117640, "reactomeId" : 10733331, "displayName" : "PIAS4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 703, "y" : 1011 }, "minX" : 588, "maxX" : 1048, "minY" : 992, "maxY" : 1025, "prop" : { "x" : 666, "y" : 998, "width" : 74, "height" : 27 }, "textPosition" : { "x" : 681, "y" : 1001 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 740, "y" : 998 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 740, "y" : 998 } } }, "connectors" : [ { "edgeId" : 117635, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 663, "y" : 1013 }, "to" : { "x" : 596, "y" : 1017 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 592, "y" : 1017 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 592, "y" : 1017 } } }, { "edgeId" : 117675, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 743, "y" : 1010 }, "to" : { "x" : 1040, "y" : 1009 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1044, "y" : 1009 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1044, "y" : 1009 } } } ] }, { "id" : 117643, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 179, "y" : 714 }, "minX" : 110, "maxX" : 254, "minY" : 695, "maxY" : 744, "prop" : { "x" : 110, "y" : 701, "width" : 138, "height" : 26 }, "textPosition" : { "x" : 119, "y" : 706 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 248, "y" : 701 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 248, "y" : 701 } } }, "connectors" : [ { "edgeId" : 117641, "type" : "INPUT", "segments" : [ { "from" : { "x" : 150, "y" : 730 }, "to" : { "x" : 114, "y" : 744 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 126, "y" : 731 }, "b" : { "x" : 138, "y" : 743 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 132, "y" : 737 } } } } ] }, { "id" : 117642, "reactomeId" : 10753062, "displayName" : "PGR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 57, "y" : 716 }, "minX" : 31, "maxX" : 114, "minY" : 698, "maxY" : 744, "prop" : { "x" : 31, "y" : 704, "width" : 53, "height" : 24 }, "textPosition" : { "x" : 41, "y" : 705 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 84, "y" : 704 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 84, "y" : 704 } } }, "connectors" : [ { "edgeId" : 117641, "type" : "INPUT", "segments" : [ { "from" : { "x" : 81, "y" : 731 }, "to" : { "x" : 114, "y" : 744 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117645, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 194, "y" : 826 }, "minX" : 113, "maxX" : 231, "minY" : 795, "maxY" : 840, "prop" : { "x" : 163, "y" : 812, "width" : 62, "height" : 28 }, "textPosition" : { "x" : 172, "y" : 815 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 225, "y" : 812 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 225, "y" : 812 } } }, "connectors" : [ { "edgeId" : 117641, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 160, "y" : 814 }, "to" : { "x" : 113, "y" : 795 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 130, "y" : 798 }, "b" : { "x" : 142, "y" : 810 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 136, "y" : 804 } } }, "endShape" : { "a" : { "x" : 152, "y" : 815 }, "b" : { "x" : 160, "y" : 814 }, "c" : { "x" : 155, "y" : 808 }, "type" : "ARROW", "centre" : { "x" : 155, "y" : 808 } } } ] }, { "id" : 117644, "reactomeId" : 10786893, "displayName" : "PGR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 74, "y" : 840 }, "minX" : 19, "maxX" : 135, "minY" : 795, "maxY" : 864, "prop" : { "x" : 19, "y" : 816, "width" : 110, "height" : 48 }, "textPosition" : { "x" : 57, "y" : 829 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 129, "y" : 816 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 129, "y" : 816 } } }, "connectors" : [ { "edgeId" : 117641, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 94, "y" : 813 }, "to" : { "x" : 113, "y" : 795 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 96, "y" : 805 }, "b" : { "x" : 94, "y" : 813 }, "c" : { "x" : 102, "y" : 811 }, "type" : "ARROW", "centre" : { "x" : 102, "y" : 811 } } } ] }, { "id" : 117646, "reactomeId" : 10784198, "displayName" : "PIAS3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 178, "y" : 773 }, "minX" : 121, "maxX" : 215, "minY" : 753, "maxY" : 787, "prop" : { "x" : 147, "y" : 759, "width" : 62, "height" : 28 }, "textPosition" : { "x" : 156, "y" : 762 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 209, "y" : 759 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 209, "y" : 759 } } }, "connectors" : [ { "edgeId" : 117641, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 144, "y" : 773 }, "to" : { "x" : 129, "y" : 773 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 125, "y" : 774 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 125, "y" : 774 } } } ] }, { "id" : 117649, "reactomeId" : 10783563, "displayName" : "SUMO2:UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 437, "y" : 701 }, "minX" : 376, "maxX" : 501, "minY" : 682, "maxY" : 760, "prop" : { "x" : 380, "y" : 688, "width" : 115, "height" : 27 }, "textPosition" : { "x" : 391, "y" : 694 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 495, "y" : 688 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 495, "y" : 688 } } }, "connectors" : [ { "edgeId" : 117647, "type" : "INPUT", "segments" : [ { "from" : { "x" : 416, "y" : 718 }, "to" : { "x" : 376, "y" : 741 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 390, "y" : 723 }, "b" : { "x" : 402, "y" : 735 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 396, "y" : 729 } } } }, { "edgeId" : 117647, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 423, "y" : 718 }, "to" : { "x" : 387, "y" : 753 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 385, "y" : 756 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 385, "y" : 756 } } } ] }, { "id" : 117648, "reactomeId" : 10753122, "displayName" : "RARA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 330, "y" : 704 }, "minX" : 295, "maxX" : 376, "minY" : 684, "maxY" : 741, "prop" : { "x" : 295, "y" : 690, "width" : 70, "height" : 28 }, "textPosition" : { "x" : 310, "y" : 693 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 365, "y" : 690 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 365, "y" : 690 } } }, "connectors" : [ { "edgeId" : 117647, "type" : "INPUT", "segments" : [ { "from" : { "x" : 347, "y" : 721 }, "to" : { "x" : 376, "y" : 741 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117651, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 449, "y" : 825 }, "minX" : 377, "maxX" : 486, "minY" : 787, "maxY" : 838, "prop" : { "x" : 418, "y" : 812, "width" : 62, "height" : 26 }, "textPosition" : { "x" : 427, "y" : 814 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 480, "y" : 812 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 480, "y" : 812 } } }, "connectors" : [ { "edgeId" : 117647, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 424, "y" : 809 }, "to" : { "x" : 377, "y" : 787 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 394, "y" : 792 }, "b" : { "x" : 406, "y" : 804 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 400, "y" : 798 } } }, "endShape" : { "a" : { "x" : 416, "y" : 810 }, "b" : { "x" : 424, "y" : 809 }, "c" : { "x" : 419, "y" : 802 }, "type" : "ARROW", "centre" : { "x" : 419, "y" : 802 } } } ] }, { "id" : 117650, "reactomeId" : 10786886, "displayName" : "RARA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 330, "y" : 835 }, "minX" : 269, "maxX" : 398, "minY" : 787, "maxY" : 861, "prop" : { "x" : 269, "y" : 809, "width" : 123, "height" : 52 }, "textPosition" : { "x" : 310, "y" : 824 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 392, "y" : 809 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 392, "y" : 809 } } }, "connectors" : [ { "edgeId" : 117647, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 355, "y" : 806 }, "to" : { "x" : 377, "y" : 787 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 358, "y" : 798 }, "b" : { "x" : 355, "y" : 806 }, "c" : { "x" : 363, "y" : 804 }, "type" : "ARROW", "centre" : { "x" : 363, "y" : 804 } } } ] }, { "id" : 117653, "reactomeId" : 10753098, "displayName" : "RORA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 737, "y" : 707 }, "minX" : 659, "maxX" : 810, "minY" : 686, "maxY" : 743, "prop" : { "x" : 708, "y" : 692, "width" : 58, "height" : 30 }, "textPosition" : { "x" : 716, "y" : 696 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 766, "y" : 692 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 766, "y" : 692 } } }, "connectors" : [ { "edgeId" : 117652, "type" : "INPUT", "segments" : [ { "from" : { "x" : 705, "y" : 720 }, "to" : { "x" : 659, "y" : 743 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 117658, "type" : "INPUT", "segments" : [ { "from" : { "x" : 769, "y" : 720 }, "to" : { "x" : 810, "y" : 742 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117655, "reactomeId" : 10787514, "displayName" : "RORA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 603, "y" : 839 }, "minX" : 551, "maxX" : 662, "minY" : 794, "maxY" : 861, "prop" : { "x" : 551, "y" : 817, "width" : 105, "height" : 44 }, "textPosition" : { "x" : 583, "y" : 828 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 656, "y" : 817 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 656, "y" : 817 } } }, "connectors" : [ { "edgeId" : 117652, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 631, "y" : 814 }, "to" : { "x" : 662, "y" : 794 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 635, "y" : 807 }, "b" : { "x" : 631, "y" : 814 }, "c" : { "x" : 639, "y" : 814 }, "type" : "ARROW", "centre" : { "x" : 639, "y" : 814 } } } ] }, { "id" : 117654, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 601, "y" : 709 }, "minX" : 534, "maxX" : 674, "minY" : 690, "maxY" : 743, "prop" : { "x" : 534, "y" : 696, "width" : 134, "height" : 27 }, "textPosition" : { "x" : 541, "y" : 702 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 668, "y" : 696 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 668, "y" : 696 } } }, "connectors" : [ { "edgeId" : 117652, "type" : "INPUT", "segments" : [ { "from" : { "x" : 624, "y" : 726 }, "to" : { "x" : 659, "y" : 743 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117657, "reactomeId" : 10787501, "displayName" : "PIAS2-2,PIAS3,PIAS4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 733, "y" : 769 }, "minX" : 667, "maxX" : 801, "minY" : 751, "maxY" : 787, "prop" : { "x" : 684, "y" : 751, "width" : 99, "height" : 36 }, "textPosition" : { "x" : 684, "y" : 751 }, "connectors" : [ { "edgeId" : 117652, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 678, "y" : 766 }, "to" : { "x" : 675, "y" : 766 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 671, "y" : 766 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 671, "y" : 766 } } }, { "edgeId" : 117658, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 789, "y" : 766 }, "to" : { "x" : 793, "y" : 766 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 797, "y" : 766 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 797, "y" : 766 } } } ] }, { "id" : 117656, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 736, "y" : 835 }, "minX" : 662, "maxX" : 809, "minY" : 794, "maxY" : 851, "prop" : { "x" : 698, "y" : 820, "width" : 77, "height" : 31 }, "textPosition" : { "x" : 714, "y" : 825 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 775, "y" : 820 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 775, "y" : 820 } } }, "connectors" : [ { "edgeId" : 117652, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 708, "y" : 817 }, "to" : { "x" : 662, "y" : 794 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 700, "y" : 817 }, "b" : { "x" : 708, "y" : 817 }, "c" : { "x" : 704, "y" : 810 }, "type" : "ARROW", "centre" : { "x" : 704, "y" : 810 } } }, { "edgeId" : 117658, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 763, "y" : 817 }, "to" : { "x" : 809, "y" : 794 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 780, "y" : 799 }, "b" : { "x" : 792, "y" : 811 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 786, "y" : 805 } } }, "endShape" : { "a" : { "x" : 767, "y" : 810 }, "b" : { "x" : 763, "y" : 817 }, "c" : { "x" : 771, "y" : 817 }, "type" : "ARROW", "centre" : { "x" : 771, "y" : 817 } } } ] }, { "id" : 117659, "reactomeId" : 10783563, "displayName" : "SUMO2:UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 863, "y" : 705 }, "minX" : 808, "maxX" : 924, "minY" : 686, "maxY" : 742, "prop" : { "x" : 808, "y" : 692, "width" : 110, "height" : 27 }, "textPosition" : { "x" : 817, "y" : 698 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 918, "y" : 692 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 918, "y" : 692 } } }, "connectors" : [ { "edgeId" : 117658, "type" : "INPUT", "segments" : [ { "from" : { "x" : 843, "y" : 722 }, "to" : { "x" : 810, "y" : 742 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 820, "y" : 726 }, "b" : { "x" : 832, "y" : 738 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 826, "y" : 732 } } } } ] }, { "id" : 117660, "reactomeId" : 10787499, "displayName" : "RORA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 858, "y" : 838 }, "minX" : 803, "maxX" : 919, "minY" : 794, "maxY" : 859, "prop" : { "x" : 803, "y" : 817, "width" : 110, "height" : 42 }, "textPosition" : { "x" : 837, "y" : 827 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 913, "y" : 817 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 913, "y" : 817 } } }, "connectors" : [ { "edgeId" : 117658, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 834, "y" : 814 }, "to" : { "x" : 809, "y" : 794 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 826, "y" : 813 }, "b" : { "x" : 834, "y" : 814 }, "c" : { "x" : 831, "y" : 807 }, "type" : "ARROW", "centre" : { "x" : 831, "y" : 807 } } } ] }, { "id" : 117663, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1139, "y" : 705 }, "minX" : 1071, "maxX" : 1213, "minY" : 686, "maxY" : 771, "prop" : { "x" : 1071, "y" : 692, "width" : 136, "height" : 27 }, "textPosition" : { "x" : 1079, "y" : 698 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1207, "y" : 692 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1207, "y" : 692 } } }, "connectors" : [ { "edgeId" : 117661, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1119, "y" : 722 }, "to" : { "x" : 1078, "y" : 748 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 117661, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1127, "y" : 722 }, "to" : { "x" : 1088, "y" : 764 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1085, "y" : 767 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1085, "y" : 767 } } } ] }, { "id" : 117662, "reactomeId" : 10745850, "displayName" : "RXRA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1001, "y" : 708 }, "minX" : 970, "maxX" : 1078, "minY" : 689, "maxY" : 748, "prop" : { "x" : 970, "y" : 695, "width" : 63, "height" : 27 }, "textPosition" : { "x" : 982, "y" : 698 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1033, "y" : 695 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1033, "y" : 695 } } }, "connectors" : [ { "edgeId" : 117661, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1026, "y" : 725 }, "to" : { "x" : 1078, "y" : 748 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117665, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1141, "y" : 837 }, "minX" : 1078, "maxX" : 1181, "minY" : 800, "maxY" : 852, "prop" : { "x" : 1108, "y" : 822, "width" : 67, "height" : 30 }, "textPosition" : { "x" : 1119, "y" : 826 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1175, "y" : 822 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1175, "y" : 822 } } }, "connectors" : [ { "edgeId" : 117661, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1115, "y" : 819 }, "to" : { "x" : 1078, "y" : 800 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1107, "y" : 819 }, "b" : { "x" : 1115, "y" : 819 }, "c" : { "x" : 1111, "y" : 812 }, "type" : "ARROW", "centre" : { "x" : 1111, "y" : 812 } } } ] }, { "id" : 117664, "reactomeId" : 10786874, "displayName" : "RXRA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1026, "y" : 852 }, "minX" : 978, "maxX" : 1080, "minY" : 800, "maxY" : 878, "prop" : { "x" : 978, "y" : 827, "width" : 96, "height" : 51 }, "textPosition" : { "x" : 1006, "y" : 842 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1074, "y" : 827 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1074, "y" : 827 } } }, "connectors" : [ { "edgeId" : 117661, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1051, "y" : 824 }, "to" : { "x" : 1078, "y" : 800 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1054, "y" : 816 }, "b" : { "x" : 1051, "y" : 824 }, "c" : { "x" : 1059, "y" : 822 }, "type" : "ARROW", "centre" : { "x" : 1059, "y" : 822 } } } ] }, { "id" : 117667, "reactomeId" : 10753134, "displayName" : "THRA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 222, "y" : 947 }, "minX" : 142, "maxX" : 267, "minY" : 927, "maxY" : 982, "prop" : { "x" : 184, "y" : 933, "width" : 77, "height" : 29 }, "textPosition" : { "x" : 202, "y" : 937 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 261, "y" : 933 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 261, "y" : 933 } } }, "connectors" : [ { "edgeId" : 117666, "type" : "INPUT", "segments" : [ { "from" : { "x" : 188, "y" : 965 }, "to" : { "x" : 142, "y" : 982 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117669, "reactomeId" : 10787520, "displayName" : "monoSUMO1-K283,K389-THRA-2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 90, "y" : 1095 }, "minX" : 25, "maxX" : 167, "minY" : 1050, "maxY" : 1118, "prop" : { "x" : 25, "y" : 1072, "width" : 131, "height" : 46 }, "textPosition" : { "x" : 27, "y" : 1077 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 156, "y" : 1072 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 156, "y" : 1072 } } }, "connectors" : [ { "edgeId" : 117666, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 129, "y" : 1069 }, "to" : { "x" : 167, "y" : 1050 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 133, "y" : 1062 }, "b" : { "x" : 129, "y" : 1069 }, "c" : { "x" : 137, "y" : 1069 }, "type" : "ARROW", "centre" : { "x" : 137, "y" : 1069 } } } ] }, { "id" : 117668, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 89, "y" : 936 }, "minX" : 20, "maxX" : 165, "minY" : 915, "maxY" : 982, "prop" : { "x" : 20, "y" : 921, "width" : 139, "height" : 30 }, "textPosition" : { "x" : 29, "y" : 930 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 159, "y" : 921 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 159, "y" : 921 } } }, "connectors" : [ { "edgeId" : 117666, "type" : "INPUT", "segments" : [ { "from" : { "x" : 106, "y" : 954 }, "to" : { "x" : 142, "y" : 982 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 118, "y" : 962 }, "b" : { "x" : 130, "y" : 974 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 124, "y" : 968 } } } } ] }, { "id" : 117671, "reactomeId" : 10783692, "displayName" : "PIAS2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 222, "y" : 1019 }, "minX" : 151, "maxX" : 271, "minY" : 997, "maxY" : 1035, "prop" : { "x" : 179, "y" : 1003, "width" : 86, "height" : 32 }, "textPosition" : { "x" : 200, "y" : 1008 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 265, "y" : 1003 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 265, "y" : 1003 } } }, "connectors" : [ { "edgeId" : 117666, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 176, "y" : 1018 }, "to" : { "x" : 159, "y" : 1018 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 155, "y" : 1018 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 155, "y" : 1018 } } } ] }, { "id" : 117670, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 211, "y" : 1100 }, "minX" : 167, "maxX" : 254, "minY" : 1050, "maxY" : 1115, "prop" : { "x" : 174, "y" : 1085, "width" : 74, "height" : 30 }, "textPosition" : { "x" : 189, "y" : 1089 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 248, "y" : 1085 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 248, "y" : 1085 } } }, "connectors" : [ { "edgeId" : 117666, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 197, "y" : 1082 }, "to" : { "x" : 167, "y" : 1050 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 176, "y" : 1060 }, "b" : { "x" : 188, "y" : 1072 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 182, "y" : 1066 } } }, "endShape" : { "a" : { "x" : 189, "y" : 1080 }, "b" : { "x" : 197, "y" : 1082 }, "c" : { "x" : 195, "y" : 1074 }, "type" : "ARROW", "centre" : { "x" : 195, "y" : 1074 } } } ] }, { "id" : 117673, "reactomeId" : 10753138, "displayName" : "THRB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 491, "y" : 267 }, "minX" : 440, "maxX" : 530, "minY" : 247, "maxY" : 297, "prop" : { "x" : 459, "y" : 253, "width" : 65, "height" : 28 }, "textPosition" : { "x" : 471, "y" : 256 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 524, "y" : 253 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 524, "y" : 253 } } }, "connectors" : [ { "edgeId" : 117672, "type" : "INPUT", "segments" : [ { "from" : { "x" : 467, "y" : 284 }, "to" : { "x" : 440, "y" : 297 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117674, "reactomeId" : 10787509, "displayName" : "monoSUMO1-K50,K146,K443-THRB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 469, "y" : 420 }, "minX" : 409, "maxX" : 536, "minY" : 359, "maxY" : 438, "prop" : { "x" : 409, "y" : 402, "width" : 121, "height" : 36 }, "textPosition" : { "x" : 410, "y" : 402 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 530, "y" : 402 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 530, "y" : 402 } } }, "connectors" : [ { "edgeId" : 117672, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 459, "y" : 399 }, "to" : { "x" : 437, "y" : 359 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 452, "y" : 395 }, "b" : { "x" : 459, "y" : 399 }, "c" : { "x" : 459, "y" : 391 }, "type" : "ARROW", "centre" : { "x" : 459, "y" : 391 } } } ] }, { "id" : 117677, "reactomeId" : 10783563, "displayName" : "SUMO2:UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1124, "y" : 946 }, "minX" : 1055, "maxX" : 1189, "minY" : 924, "maxY" : 985, "prop" : { "x" : 1065, "y" : 930, "width" : 118, "height" : 32 }, "textPosition" : { "x" : 1078, "y" : 941 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1183, "y" : 930 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1183, "y" : 930 } } }, "connectors" : [ { "edgeId" : 117675, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1095, "y" : 965 }, "to" : { "x" : 1055, "y" : 985 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1069, "y" : 969 }, "b" : { "x" : 1081, "y" : 981 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1075, "y" : 975 } } } } ] }, { "id" : 117676, "reactomeId" : 10753046, "displayName" : "VDR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1009, "y" : 949 }, "minX" : 984, "maxX" : 1055, "minY" : 930, "maxY" : 985, "prop" : { "x" : 984, "y" : 936, "width" : 51, "height" : 27 }, "textPosition" : { "x" : 993, "y" : 939 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1035, "y" : 936 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1035, "y" : 936 } } }, "connectors" : [ { "edgeId" : 117675, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1026, "y" : 966 }, "to" : { "x" : 1055, "y" : 985 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117679, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 932, "y" : 1088 }, "minX" : 899, "maxX" : 1055, "minY" : 1038, "maxY" : 1103, "prop" : { "x" : 899, "y" : 1074, "width" : 67, "height" : 29 }, "textPosition" : { "x" : 910, "y" : 1078 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 966, "y" : 1074 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 966, "y" : 1074 } } }, "connectors" : [ { "edgeId" : 117675, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 969, "y" : 1074 }, "to" : { "x" : 1055, "y" : 1038 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1006, "y" : 1050 }, "b" : { "x" : 1018, "y" : 1062 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1012, "y" : 1056 } } }, "endShape" : { "a" : { "x" : 974, "y" : 1068 }, "b" : { "x" : 969, "y" : 1074 }, "c" : { "x" : 977, "y" : 1075 }, "type" : "ARROW", "centre" : { "x" : 977, "y" : 1075 } } } ] }, { "id" : 117678, "reactomeId" : 10787027, "displayName" : "VDR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1120, "y" : 1092 }, "minX" : 1055, "maxX" : 1186, "minY" : 1038, "maxY" : 1112, "prop" : { "x" : 1061, "y" : 1073, "width" : 119, "height" : 39 }, "textPosition" : { "x" : 1104, "y" : 1082 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1180, "y" : 1073 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1180, "y" : 1073 } } }, "connectors" : [ { "edgeId" : 117675, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1096, "y" : 1070 }, "to" : { "x" : 1055, "y" : 1038 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1088, "y" : 1069 }, "b" : { "x" : 1096, "y" : 1070 }, "c" : { "x" : 1093, "y" : 1063 }, "type" : "ARROW", "centre" : { "x" : 1093, "y" : 1063 } } } ] }, { "id" : 117589, "reactomeId" : 10753074, "displayName" : "AR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 94, "y" : 57 }, "minX" : 60, "maxX" : 161, "minY" : 39, "maxY" : 84, "prop" : { "x" : 60, "y" : 45, "width" : 69, "height" : 25 }, "textPosition" : { "x" : 82, "y" : 47 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 129, "y" : 45 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 129, "y" : 45 } } }, "connectors" : [ { "edgeId" : 117588, "type" : "INPUT", "segments" : [ { "from" : { "x" : 125, "y" : 73 }, "to" : { "x" : 161, "y" : 84 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117591, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 236, "y" : 190 }, "minX" : 135, "maxX" : 311, "minY" : 128, "maxY" : 203, "prop" : { "x" : 194, "y" : 178, "width" : 84, "height" : 25 }, "textPosition" : { "x" : 214, "y" : 180 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 278, "y" : 178 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 278, "y" : 178 } } }, "connectors" : [ { "edgeId" : 117588, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 215, "y" : 175 }, "to" : { "x" : 135, "y" : 128 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 169, "y" : 145 }, "b" : { "x" : 181, "y" : 157 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 175, "y" : 151 } } }, "endShape" : { "a" : { "x" : 207, "y" : 175 }, "b" : { "x" : 215, "y" : 175 }, "c" : { "x" : 211, "y" : 168 }, "type" : "ARROW", "centre" : { "x" : 211, "y" : 168 } } }, { "edgeId" : 117594, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 251, "y" : 175 }, "to" : { "x" : 311, "y" : 131 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 275, "y" : 147 }, "b" : { "x" : 287, "y" : 159 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 281, "y" : 153 } } }, "endShape" : { "a" : { "x" : 254, "y" : 168 }, "b" : { "x" : 251, "y" : 175 }, "c" : { "x" : 259, "y" : 174 }, "type" : "ARROW", "centre" : { "x" : 259, "y" : 174 } } } ] }, { "id" : 117590, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 226, "y" : 52 }, "minX" : 156, "maxX" : 302, "minY" : 33, "maxY" : 85, "prop" : { "x" : 156, "y" : 39, "width" : 140, "height" : 26 }, "textPosition" : { "x" : 166, "y" : 44 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 296, "y" : 39 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 296, "y" : 39 } } }, "connectors" : [ { "edgeId" : 117588, "type" : "INPUT", "segments" : [ { "from" : { "x" : 199, "y" : 68 }, "to" : { "x" : 161, "y" : 84 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 174, "y" : 70 }, "b" : { "x" : 186, "y" : 82 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 180, "y" : 76 } } } }, { "edgeId" : 117594, "type" : "INPUT", "segments" : [ { "from" : { "x" : 249, "y" : 68 }, "to" : { "x" : 286, "y" : 85 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 261, "y" : 70 }, "b" : { "x" : 273, "y" : 82 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 267, "y" : 76 } } } } ] }, { "id" : 117593, "reactomeId" : 10786745, "displayName" : "PIAS1,2-1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 77, "y" : 104 }, "minX" : 28, "maxX" : 152, "minY" : 93, "maxY" : 116, "prop" : { "x" : 28, "y" : 93, "width" : 98, "height" : 23 }, "textPosition" : { "x" : 43, "y" : 94 }, "connectors" : [ { "edgeId" : 117588, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 132, "y" : 105 }, "to" : { "x" : 144, "y" : 105 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 148, "y" : 106 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 148, "y" : 106 } } } ] }, { "id" : 117592, "reactomeId" : 10786759, "displayName" : "AR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 87, "y" : 185 }, "minX" : 29, "maxX" : 151, "minY" : 128, "maxY" : 210, "prop" : { "x" : 29, "y" : 160, "width" : 116, "height" : 50 }, "textPosition" : { "x" : 75, "y" : 174 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 145, "y" : 160 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 145, "y" : 160 } } }, "connectors" : [ { "edgeId" : 117588, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 108, "y" : 157 }, "to" : { "x" : 135, "y" : 128 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 110, "y" : 149 }, "b" : { "x" : 108, "y" : 157 }, "c" : { "x" : 116, "y" : 155 }, "type" : "ARROW", "centre" : { "x" : 116, "y" : 155 } } } ] }, { "id" : 117595, "reactomeId" : 10753078, "displayName" : "ESR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 344, "y" : 58 }, "minX" : 286, "maxX" : 378, "minY" : 40, "maxY" : 85, "prop" : { "x" : 316, "y" : 46, "width" : 56, "height" : 24 }, "textPosition" : { "x" : 324, "y" : 47 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 372, "y" : 46 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 372, "y" : 46 } } }, "connectors" : [ { "edgeId" : 117594, "type" : "INPUT", "segments" : [ { "from" : { "x" : 318, "y" : 73 }, "to" : { "x" : 286, "y" : 85 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117597, "reactomeId" : 10786619, "displayName" : "PIAS1,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 379, "y" : 103 }, "minX" : 294, "maxX" : 413, "minY" : 91, "maxY" : 115, "prop" : { "x" : 345, "y" : 91, "width" : 68, "height" : 24 }, "textPosition" : { "x" : 351, "y" : 92 }, "connectors" : [ { "edgeId" : 117594, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 339, "y" : 104 }, "to" : { "x" : 302, "y" : 107 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 298, "y" : 107 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 298, "y" : 107 } } } ] }, { "id" : 117596, "reactomeId" : 10786768, "displayName" : "ESR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 371, "y" : 183 }, "minX" : 311, "maxX" : 429, "minY" : 131, "maxY" : 206, "prop" : { "x" : 320, "y" : 160, "width" : 103, "height" : 46 }, "textPosition" : { "x" : 351, "y" : 172 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 423, "y" : 160 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 423, "y" : 160 } } }, "connectors" : [ { "edgeId" : 117594, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 344, "y" : 157 }, "to" : { "x" : 311, "y" : 131 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 336, "y" : 156 }, "b" : { "x" : 344, "y" : 157 }, "c" : { "x" : 341, "y" : 150 }, "type" : "ARROW", "centre" : { "x" : 341, "y" : 150 } } } ] }, { "id" : 117599, "reactomeId" : 10787524, "displayName" : "NR1H3:hydroxycholesterol", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 841, "y" : 55 }, "minX" : 730, "maxX" : 912, "minY" : 32, "maxY" : 107, "prop" : { "x" : 776, "y" : 38, "width" : 130, "height" : 34 }, "textPosition" : { "x" : 778, "y" : 37 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 906, "y" : 38 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 906, "y" : 38 } } }, "connectors" : [ { "edgeId" : 117598, "type" : "INPUT", "segments" : [ { "from" : { "x" : 804, "y" : 75 }, "to" : { "x" : 730, "y" : 107 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117601, "reactomeId" : 10787529, "displayName" : "SUMO2,3-NR1H3:hydroxysterol", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 839, "y" : 192 }, "minX" : 752, "maxX" : 903, "minY" : 158, "maxY" : 211, "prop" : { "x" : 782, "y" : 173, "width" : 115, "height" : 38 }, "textPosition" : { "x" : 782, "y" : 176 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 897, "y" : 173 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 897, "y" : 173 } } }, "connectors" : [ { "edgeId" : 117598, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 790, "y" : 170 }, "to" : { "x" : 752, "y" : 158 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 782, "y" : 172 }, "b" : { "x" : 790, "y" : 170 }, "c" : { "x" : 785, "y" : 164 }, "type" : "ARROW", "centre" : { "x" : 785, "y" : 164 } } } ] }, { "id" : 117600, "reactomeId" : 10783563, "displayName" : "SUMO2:UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 674, "y" : 55 }, "minX" : 616, "maxX" : 738, "minY" : 29, "maxY" : 107, "prop" : { "x" : 616, "y" : 35, "width" : 116, "height" : 40 }, "textPosition" : { "x" : 628, "y" : 44 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 732, "y" : 35 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 732, "y" : 35 } } }, "connectors" : [ { "edgeId" : 117598, "type" : "INPUT", "segments" : [ { "from" : { "x" : 695, "y" : 81 }, "to" : { "x" : 730, "y" : 107 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 706, "y" : 88 }, "b" : { "x" : 718, "y" : 100 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 712, "y" : 94 } } } } ] }, { "id" : 117603, "reactomeId" : 10751727, "displayName" : "HDAC4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 678, "y" : 129 }, "minX" : 644, "maxX" : 743, "minY" : 109, "maxY" : 144, "prop" : { "x" : 644, "y" : 115, "width" : 69, "height" : 29 }, "textPosition" : { "x" : 653, "y" : 119 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 713, "y" : 115 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 713, "y" : 115 } } }, "connectors" : [ { "edgeId" : 117598, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 716, "y" : 130 }, "to" : { "x" : 735, "y" : 132 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 739, "y" : 132 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 739, "y" : 132 } } } ] }, { "id" : 117602, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 678, "y" : 183 }, "minX" : 648, "maxX" : 752, "minY" : 158, "maxY" : 196, "prop" : { "x" : 648, "y" : 171, "width" : 60, "height" : 25 }, "textPosition" : { "x" : 656, "y" : 173 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 708, "y" : 171 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 708, "y" : 171 } } }, "connectors" : [ { "edgeId" : 117598, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 711, "y" : 172 }, "to" : { "x" : 752, "y" : 158 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 725, "y" : 159 }, "b" : { "x" : 737, "y" : 171 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 731, "y" : 165 } } }, "endShape" : { "a" : { "x" : 716, "y" : 166 }, "b" : { "x" : 711, "y" : 172 }, "c" : { "x" : 719, "y" : 174 }, "type" : "ARROW", "centre" : { "x" : 719, "y" : 174 } } } ] }, { "id" : 117605, "reactomeId" : 10787542, "displayName" : "NR1H4:chenodeoxycholate", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1002, "y" : 71 }, "minX" : 936, "maxX" : 1098, "minY" : 46, "maxY" : 109, "prop" : { "x" : 936, "y" : 52, "width" : 133, "height" : 39 }, "textPosition" : { "x" : 937, "y" : 56 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1069, "y" : 52 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1069, "y" : 52 } } }, "connectors" : [ { "edgeId" : 117604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1051, "y" : 94 }, "to" : { "x" : 1098, "y" : 109 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117607, "reactomeId" : 10787548, "displayName" : "monoSUMO1-NR1H4:chenodeoxycholate", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1019, "y" : 197 }, "minX" : 942, "maxX" : 1102, "minY" : 153, "maxY" : 217, "prop" : { "x" : 942, "y" : 178, "width" : 154, "height" : 39 }, "textPosition" : { "x" : 950, "y" : 182 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1096, "y" : 178 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1096, "y" : 178 } } }, "connectors" : [ { "edgeId" : 117604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1054, "y" : 175 }, "to" : { "x" : 1100, "y" : 153 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1059, "y" : 168 }, "b" : { "x" : 1054, "y" : 175 }, "c" : { "x" : 1062, "y" : 176 }, "type" : "ARROW", "centre" : { "x" : 1062, "y" : 176 } } } ] }, { "id" : 117606, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1152, "y" : 73 }, "minX" : 1082, "maxX" : 1229, "minY" : 55, "maxY" : 109, "prop" : { "x" : 1082, "y" : 61, "width" : 141, "height" : 25 }, "textPosition" : { "x" : 1092, "y" : 65 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1223, "y" : 61 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1223, "y" : 61 } } }, "connectors" : [ { "edgeId" : 117604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1133, "y" : 89 }, "to" : { "x" : 1098, "y" : 109 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1109, "y" : 93 }, "b" : { "x" : 1121, "y" : 105 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1115, "y" : 99 } } } } ] }, { "id" : 117608, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1161, "y" : 199 }, "minX" : 1100, "maxX" : 1201, "minY" : 153, "maxY" : 212, "prop" : { "x" : 1128, "y" : 187, "width" : 67, "height" : 25 }, "textPosition" : { "x" : 1139, "y" : 189 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1195, "y" : 187 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1195, "y" : 187 } } }, "connectors" : [ { "edgeId" : 117604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1144, "y" : 184 }, "to" : { "x" : 1100, "y" : 153 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1116, "y" : 162 }, "b" : { "x" : 1128, "y" : 174 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1122, "y" : 168 } } }, "endShape" : { "a" : { "x" : 1136, "y" : 183 }, "b" : { "x" : 1144, "y" : 184 }, "c" : { "x" : 1141, "y" : 177 }, "type" : "ARROW", "centre" : { "x" : 1141, "y" : 177 } } } ] }, { "id" : 117611, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 325, "y" : 249 }, "minX" : 236, "maxX" : 440, "minY" : 230, "maxY" : 314, "prop" : { "x" : 255, "y" : 236, "width" : 141, "height" : 27 }, "textPosition" : { "x" : 265, "y" : 242 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 396, "y" : 236 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 396, "y" : 236 } } }, "connectors" : [ { "edgeId" : 117609, "type" : "INPUT", "segments" : [ { "from" : { "x" : 306, "y" : 266 }, "to" : { "x" : 236, "y" : 314 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 265, "y" : 284 }, "b" : { "x" : 277, "y" : 296 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 271, "y" : 290 } } } }, { "edgeId" : 117672, "type" : "INPUT", "segments" : [ { "from" : { "x" : 357, "y" : 266 }, "to" : { "x" : 440, "y" : 297 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 392, "y" : 275 }, "b" : { "x" : 404, "y" : 287 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 398, "y" : 281 } } } } ] }, { "id" : 117610, "reactomeId" : 10753162, "displayName" : "NR3C2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 167, "y" : 253 }, "minX" : 132, "maxX" : 236, "minY" : 235, "maxY" : 314, "prop" : { "x" : 132, "y" : 241, "width" : 70, "height" : 24 }, "textPosition" : { "x" : 142, "y" : 242 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 202, "y" : 241 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 202, "y" : 241 } } }, "connectors" : [ { "edgeId" : 117609, "type" : "INPUT", "segments" : [ { "from" : { "x" : 180, "y" : 268 }, "to" : { "x" : 236, "y" : 314 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117613, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 341, "y" : 405 }, "minX" : 236, "maxX" : 437, "minY" : 359, "maxY" : 418, "prop" : { "x" : 307, "y" : 393, "width" : 69, "height" : 25 }, "textPosition" : { "x" : 319, "y" : 395 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 376, "y" : 393 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 376, "y" : 393 } } }, "connectors" : [ { "edgeId" : 117609, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 309, "y" : 390 }, "to" : { "x" : 236, "y" : 363 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 266, "y" : 370 }, "b" : { "x" : 278, "y" : 382 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 272, "y" : 376 } } }, "endShape" : { "a" : { "x" : 301, "y" : 391 }, "b" : { "x" : 309, "y" : 390 }, "c" : { "x" : 304, "y" : 384 }, "type" : "ARROW", "centre" : { "x" : 304, "y" : 384 } } }, { "edgeId" : 117672, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 367, "y" : 390 }, "to" : { "x" : 437, "y" : 359 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 396, "y" : 368 }, "b" : { "x" : 408, "y" : 380 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 402, "y" : 374 } } }, "endShape" : { "a" : { "x" : 372, "y" : 384 }, "b" : { "x" : 367, "y" : 390 }, "c" : { "x" : 375, "y" : 391 }, "type" : "ARROW", "centre" : { "x" : 375, "y" : 391 } } } ] }, { "id" : 117612, "reactomeId" : 10786855, "displayName" : "NR3C2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 205, "y" : 425 }, "minX" : 147, "maxX" : 270, "minY" : 363, "maxY" : 453, "prop" : { "x" : 147, "y" : 398, "width" : 117, "height" : 55 }, "textPosition" : { "x" : 181, "y" : 415 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 264, "y" : 398 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 264, "y" : 398 } } }, "connectors" : [ { "edgeId" : 117609, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 218, "y" : 395 }, "to" : { "x" : 236, "y" : 363 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 218, "y" : 387 }, "b" : { "x" : 218, "y" : 395 }, "c" : { "x" : 225, "y" : 391 }, "type" : "ARROW", "centre" : { "x" : 225, "y" : 391 } } } ] }, { "id" : 117614, "reactomeId" : 10762876, "displayName" : "PIAS1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 342, "y" : 318 }, "minX" : 243, "maxX" : 431, "minY" : 300, "maxY" : 344, "prop" : { "x" : 312, "y" : 306, "width" : 60, "height" : 25 }, "textPosition" : { "x" : 320, "y" : 308 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 372, "y" : 306 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 372, "y" : 306 } } }, "connectors" : [ { "edgeId" : 117609, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 309, "y" : 325 }, "to" : { "x" : 251, "y" : 339 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 247, "y" : 340 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 247, "y" : 340 } } }, { "edgeId" : 117672, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 375, "y" : 323 }, "to" : { "x" : 423, "y" : 333 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 427, "y" : 334 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 427, "y" : 334 } } } ] }, { "id" : 117617, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 891, "y" : 488 }, "minX" : 798, "maxX" : 971, "minY" : 469, "maxY" : 547, "prop" : { "x" : 817, "y" : 475, "width" : 148, "height" : 27 }, "textPosition" : { "x" : 831, "y" : 481 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 965, "y" : 475 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 965, "y" : 475 } } }, "connectors" : [ { "edgeId" : 117615, "type" : "INPUT", "segments" : [ { "from" : { "x" : 857, "y" : 505 }, "to" : { "x" : 798, "y" : 525 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 821, "y" : 509 }, "b" : { "x" : 833, "y" : 521 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 827, "y" : 515 } } } }, { "edgeId" : 117615, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 870, "y" : 505 }, "to" : { "x" : 814, "y" : 540 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 810, "y" : 543 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 810, "y" : 543 } } } ] }, { "id" : 117616, "reactomeId" : 10786861, "displayName" : "NR3C1:(ALDO,11DCORST,CORST,CORT) dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 749, "y" : 478 }, "minX" : 689, "maxX" : 815, "minY" : 447, "maxY" : 525, "prop" : { "x" : 689, "y" : 453, "width" : 120, "height" : 51 }, "textPosition" : { "x" : 702, "y" : 441 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 809, "y" : 453 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 809, "y" : 453 } } }, "connectors" : [ { "edgeId" : 117615, "type" : "INPUT", "segments" : [ { "from" : { "x" : 775, "y" : 507 }, "to" : { "x" : 798, "y" : 525 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117619, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 895, "y" : 609 }, "minX" : 801, "maxX" : 935, "minY" : 569, "maxY" : 623, "prop" : { "x" : 862, "y" : 596, "width" : 67, "height" : 27 }, "textPosition" : { "x" : 873, "y" : 599 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 929, "y" : 596 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 929, "y" : 596 } } }, "connectors" : [ { "edgeId" : 117615, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 863, "y" : 593 }, "to" : { "x" : 801, "y" : 569 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 826, "y" : 575 }, "b" : { "x" : 838, "y" : 587 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 832, "y" : 581 } } }, "endShape" : { "a" : { "x" : 855, "y" : 594 }, "b" : { "x" : 863, "y" : 593 }, "c" : { "x" : 858, "y" : 587 }, "type" : "ARROW", "centre" : { "x" : 858, "y" : 587 } } } ] }, { "id" : 117618, "reactomeId" : 10786869, "displayName" : "2SUMO1:NR3C1:Glucocorticoid ligand dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 758, "y" : 611 }, "minX" : 675, "maxX" : 847, "minY" : 569, "maxY" : 628, "prop" : { "x" : 675, "y" : 594, "width" : 166, "height" : 34 }, "textPosition" : { "x" : 686, "y" : 579 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 841, "y" : 594 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 841, "y" : 594 } } }, "connectors" : [ { "edgeId" : 117615, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 775, "y" : 591 }, "to" : { "x" : 801, "y" : 569 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 778, "y" : 583 }, "b" : { "x" : 775, "y" : 591 }, "c" : { "x" : 783, "y" : 590 }, "type" : "ARROW", "centre" : { "x" : 783, "y" : 590 } } } ] }, { "id" : 117621, "reactomeId" : 10753142, "displayName" : "NR5A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 196, "y" : 486 }, "minX" : 128, "maxX" : 259, "minY" : 466, "maxY" : 529, "prop" : { "x" : 161, "y" : 472, "width" : 71, "height" : 29 }, "textPosition" : { "x" : 172, "y" : 476 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 232, "y" : 472 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 232, "y" : 472 } } }, "connectors" : [ { "edgeId" : 117620, "type" : "INPUT", "segments" : [ { "from" : { "x" : 170, "y" : 504 }, "to" : { "x" : 128, "y" : 525 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 117626, "type" : "INPUT", "segments" : [ { "from" : { "x" : 217, "y" : 504 }, "to" : { "x" : 259, "y" : 529 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117623, "reactomeId" : 10787022, "displayName" : "monoSUMO1-K119,K194-NR5A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 72, "y" : 635 }, "minX" : 17, "maxX" : 134, "minY" : 576, "maxY" : 660, "prop" : { "x" : 17, "y" : 610, "width" : 111, "height" : 50 }, "textPosition" : { "x" : 27, "y" : 610 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 128, "y" : 610 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 128, "y" : 610 } } }, "connectors" : [ { "edgeId" : 117620, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 96, "y" : 607 }, "to" : { "x" : 129, "y" : 576 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 98, "y" : 599 }, "b" : { "x" : 96, "y" : 607 }, "c" : { "x" : 104, "y" : 605 }, "type" : "ARROW", "centre" : { "x" : 104, "y" : 605 } } } ] }, { "id" : 117622, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 82, "y" : 482 }, "minX" : 15, "maxX" : 155, "minY" : 463, "maxY" : 525, "prop" : { "x" : 15, "y" : 469, "width" : 134, "height" : 27 }, "textPosition" : { "x" : 22, "y" : 475 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 149, "y" : 469 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 149, "y" : 469 } } }, "connectors" : [ { "edgeId" : 117620, "type" : "INPUT", "segments" : [ { "from" : { "x" : 96, "y" : 499 }, "to" : { "x" : 128, "y" : 525 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 106, "y" : 506 }, "b" : { "x" : 118, "y" : 518 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 112, "y" : 512 } } } } ] }, { "id" : 117625, "reactomeId" : 10786619, "displayName" : "PIAS1,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 189, "y" : 549 }, "minX" : 135, "maxX" : 250, "minY" : 536, "maxY" : 563, "prop" : { "x" : 154, "y" : 536, "width" : 71, "height" : 27 }, "textPosition" : { "x" : 162, "y" : 539 }, "connectors" : [ { "edgeId" : 117620, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 148, "y" : 549 }, "to" : { "x" : 143, "y" : 549 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 139, "y" : 549 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 139, "y" : 549 } } }, { "edgeId" : 117626, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 231, "y" : 550 }, "to" : { "x" : 242, "y" : 550 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 246, "y" : 551 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 246, "y" : 551 } } } ] }, { "id" : 117624, "reactomeId" : 10783487, "displayName" : "UBE2I", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 191, "y" : 623 }, "minX" : 129, "maxX" : 259, "minY" : 576, "maxY" : 638, "prop" : { "x" : 161, "y" : 608, "width" : 61, "height" : 30 }, "textPosition" : { "x" : 169, "y" : 612 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 222, "y" : 608 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 222, "y" : 608 } } }, "connectors" : [ { "edgeId" : 117620, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 171, "y" : 605 }, "to" : { "x" : 129, "y" : 576 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 144, "y" : 584 }, "b" : { "x" : 156, "y" : 596 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 150, "y" : 590 } } }, "endShape" : { "a" : { "x" : 163, "y" : 604 }, "b" : { "x" : 171, "y" : 605 }, "c" : { "x" : 168, "y" : 598 }, "type" : "ARROW", "centre" : { "x" : 168, "y" : 598 } } }, { "edgeId" : 117626, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 212, "y" : 605 }, "to" : { "x" : 259, "y" : 576 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 229, "y" : 584 }, "b" : { "x" : 241, "y" : 596 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 235, "y" : 590 } } }, "endShape" : { "a" : { "x" : 216, "y" : 598 }, "b" : { "x" : 212, "y" : 605 }, "c" : { "x" : 220, "y" : 605 }, "type" : "ARROW", "centre" : { "x" : 220, "y" : 605 } } } ] }, { "id" : 117627, "reactomeId" : 10783563, "displayName" : "SUMO2:UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 311, "y" : 488 }, "minX" : 257, "maxX" : 372, "minY" : 467, "maxY" : 529, "prop" : { "x" : 257, "y" : 473, "width" : 109, "height" : 30 }, "textPosition" : { "x" : 265, "y" : 482 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 366, "y" : 473 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 366, "y" : 473 } } }, "connectors" : [ { "edgeId" : 117626, "type" : "INPUT", "segments" : [ { "from" : { "x" : 291, "y" : 506 }, "to" : { "x" : 259, "y" : 529 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 269, "y" : 511 }, "b" : { "x" : 281, "y" : 523 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 275, "y" : 517 } } } } ] }, { "id" : 117628, "reactomeId" : 10787016, "displayName" : "polySUMO2-K119,K194-NR5A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 310, "y" : 630 }, "minX" : 259, "maxX" : 365, "minY" : 576, "maxY" : 655, "prop" : { "x" : 261, "y" : 605, "width" : 98, "height" : 50 }, "textPosition" : { "x" : 269, "y" : 605 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 359, "y" : 605 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 359, "y" : 605 } } }, "connectors" : [ { "edgeId" : 117626, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 286, "y" : 602 }, "to" : { "x" : 259, "y" : 576 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 278, "y" : 600 }, "b" : { "x" : 286, "y" : 602 }, "c" : { "x" : 284, "y" : 594 }, "type" : "ARROW", "centre" : { "x" : 284, "y" : 594 } } } ] }, { "id" : 117631, "reactomeId" : 10783495, "displayName" : "SUMO1:C93-UBE2I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 607, "y" : 492 }, "minX" : 538, "maxX" : 679, "minY" : 470, "maxY" : 521, "prop" : { "x" : 541, "y" : 476, "width" : 132, "height" : 32 }, "textPosition" : { "x" : 547, "y" : 487 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 673, "y" : 476 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 673, "y" : 476 } } }, "connectors" : [ { "edgeId" : 117629, "type" : "INPUT", "segments" : [ { "from" : { "x" : 568, "y" : 511 }, "to" : { "x" : 538, "y" : 521 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 117630, "reactomeId" : 10787576, "displayName" : "NR5A2:cis-bicyclo(3.3.0)oct-2-ene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 462, "y" : 493 }, "minX" : 392, "maxX" : 538, "minY" : 469, "maxY" : 521, "prop" : { "x" : 392, "y" : 475, "width" : 140, "height" : 36 }, "textPosition" : { "x" : 404, "y" : 476 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 532, "y" : 475 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 532, "y" : 475 } } }, "connectors" : [ { "edgeId" : 117629, "type" : "INPUT", "segments" : [ { "from" : { "x" : 510, "y" : 514 }, "to" : { "x" : 538, "y" : 521 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 117635, "reactomeId" : 10786881, "displayName" : "PIAS4 SUMOylates PPARA with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 580, "y" : 1018 }, "minX" : 574, "maxX" : 600, "minY" : 983, "maxY" : 1048, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 578, "y" : 983 }, "to" : { "x" : 580, "y" : 1018 } }, { "from" : { "x" : 580, "y" : 1018 }, "to" : { "x" : 600, "y" : 1048 } } ], "reactionShape" : { "a" : { "x" : 574, "y" : 1012 }, "b" : { "x" : 586, "y" : 1024 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 580, "y" : 1018 } }, "inputs" : [ { "id" : 117636, "points" : [ { "x" : 544, "y" : 961 } ] }, { "id" : 117637, "points" : [ { "x" : 617, "y" : 963 } ] } ], "outputs" : [ { "id" : 117638, "points" : [ { "x" : 557, "y" : 1074 } ] }, { "id" : 117639, "points" : [ { "x" : 626, "y" : 1078 } ] } ], "catalysts" : [ { "id" : 117640, "points" : [ { "x" : 663, "y" : 1013 } ] } ] }, { "id" : 117666, "reactomeId" : 10787522, "displayName" : "PIAS2-2 SUMOylates THRA with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 143, "y" : 1018 }, "minX" : 137, "maxX" : 167, "minY" : 982, "maxY" : 1050, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 142, "y" : 982 }, "to" : { "x" : 143, "y" : 1018 } }, { "from" : { "x" : 143, "y" : 1018 }, "to" : { "x" : 167, "y" : 1050 } } ], "reactionShape" : { "a" : { "x" : 137, "y" : 1012 }, "b" : { "x" : 149, "y" : 1024 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 143, "y" : 1018 } }, "inputs" : [ { "id" : 117667, "points" : [ { "x" : 188, "y" : 965 } ] }, { "id" : 117668, "points" : [ { "x" : 106, "y" : 954 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 117669, "points" : [ { "x" : 129, "y" : 1069 } ] }, { "id" : 117670, "points" : [ { "x" : 197, "y" : 1082 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 117671, "points" : [ { "x" : 176, "y" : 1018 } ] } ] }, { "id" : 117604, "reactomeId" : 10787550, "displayName" : "SUMOylation of NR1H4 with SUMO1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1099, "y" : 131 }, "minX" : 1093, "maxX" : 1105, "minY" : 109, "maxY" : 153, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1098, "y" : 109 }, "to" : { "x" : 1099, "y" : 131 } }, { "from" : { "x" : 1099, "y" : 131 }, "to" : { "x" : 1100, "y" : 153 } } ], "reactionShape" : { "a" : { "x" : 1093, "y" : 125 }, "b" : { "x" : 1105, "y" : 137 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1099, "y" : 131 } }, "inputs" : [ { "id" : 117605, "points" : [ { "x" : 1051, "y" : 94 } ] }, { "id" : 117606, "points" : [ { "x" : 1133, "y" : 89 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 117607, "points" : [ { "x" : 1054, "y" : 175 } ] }, { "id" : 117608, "points" : [ { "x" : 1144, "y" : 184 } ], "stoichiometry" : 2 } ] }, { "id" : 117641, "reactomeId" : 10786895, "displayName" : "PIAS3 SUMOylates PGR with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 113, "y" : 774 }, "minX" : 107, "maxX" : 119, "minY" : 744, "maxY" : 795, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 114, "y" : 744 }, "to" : { "x" : 113, "y" : 774 } }, { "from" : { "x" : 113, "y" : 774 }, "to" : { "x" : 113, "y" : 795 } } ], "reactionShape" : { "a" : { "x" : 107, "y" : 768 }, "b" : { "x" : 119, "y" : 780 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 113, "y" : 774 } }, "inputs" : [ { "id" : 117642, "points" : [ { "x" : 81, "y" : 731 } ] }, { "id" : 117643, "points" : [ { "x" : 150, "y" : 730 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 117644, "points" : [ { "x" : 94, "y" : 813 } ] }, { "id" : 117645, "points" : [ { "x" : 160, "y" : 814 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 117646, "points" : [ { "x" : 144, "y" : 773 } ] } ] }, { "id" : 117609, "reactomeId" : 10786857, "displayName" : "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 235, "y" : 343 }, "minX" : 229, "maxX" : 241, "minY" : 314, "maxY" : 363, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 236, "y" : 314 }, "to" : { "x" : 235, "y" : 343 } }, { "from" : { "x" : 235, "y" : 343 }, "to" : { "x" : 236, "y" : 363 } } ], "reactionShape" : { "a" : { "x" : 229, "y" : 337 }, "b" : { "x" : 241, "y" : 349 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 235, "y" : 343 } }, "inputs" : [ { "id" : 117610, "points" : [ { "x" : 180, "y" : 268 } ] }, { "id" : 117611, "points" : [ { "x" : 306, "y" : 266 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 117612, "points" : [ { "x" : 218, "y" : 395 } ] }, { "id" : 117613, "points" : [ { "x" : 309, "y" : 390 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 117614, "points" : [ { "x" : 309, "y" : 325 } ] } ] }, { "id" : 117672, "reactomeId" : 10787511, "displayName" : "PIAS1 SUMOylates THRB with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 439, "y" : 336 }, "minX" : 433, "maxX" : 445, "minY" : 297, "maxY" : 359, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 440, "y" : 297 }, "to" : { "x" : 439, "y" : 336 } }, { "from" : { "x" : 439, "y" : 336 }, "to" : { "x" : 437, "y" : 359 } } ], "reactionShape" : { "a" : { "x" : 433, "y" : 330 }, "b" : { "x" : 445, "y" : 342 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 439, "y" : 336 } }, "inputs" : [ { "id" : 117673, "points" : [ { "x" : 467, "y" : 284 } ] }, { "id" : 117611, "points" : [ { "x" : 357, "y" : 266 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 117674, "points" : [ { "x" : 459, "y" : 399 } ] }, { "id" : 117613, "points" : [ { "x" : 367, "y" : 390 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 117614, "points" : [ { "x" : 375, "y" : 323 } ] } ] }, { "id" : 117675, "reactomeId" : 10787029, "displayName" : "PIAS4 SUMOylates VDR with SUMO2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1056, "y" : 1009 }, "minX" : 1050, "maxX" : 1062, "minY" : 985, "maxY" : 1038, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1055, "y" : 985 }, "to" : { "x" : 1056, "y" : 1009 } }, { "from" : { "x" : 1056, "y" : 1009 }, "to" : { "x" : 1055, "y" : 1038 } } ], "reactionShape" : { "a" : { "x" : 1050, "y" : 1003 }, "b" : { "x" : 1062, "y" : 1015 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1056, "y" : 1009 } }, "inputs" : [ { "id" : 117676, "points" : [ { "x" : 1026, "y" : 966 } ] }, { "id" : 117677, "points" : [ { "x" : 1095, "y" : 965 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 117678, "points" : [ { "x" : 1096, "y" : 1070 } ] }, { "id" : 117679, "points" : [ { "x" : 969, "y" : 1074 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 117640, "points" : [ { "x" : 743, "y" : 1010 } ] } ] }, { "id" : 117647, "reactomeId" : 10786888, "displayName" : "SUMOylation of RARA with SUMO2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 376, "y" : 764 }, "minX" : 370, "maxX" : 382, "minY" : 741, "maxY" : 787, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 376, "y" : 741 }, "to" : { "x" : 376, "y" : 764 } }, { "from" : { "x" : 376, "y" : 764 }, "to" : { "x" : 377, "y" : 787 } } ], "reactionShape" : { "a" : { "x" : 370, "y" : 758 }, "b" : { "x" : 382, "y" : 770 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 376, "y" : 764 } }, "inputs" : [ { "id" : 117648, "points" : [ { "x" : 347, "y" : 721 } ] }, { "id" : 117649, "points" : [ { "x" : 416, "y" : 718 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 117650, "points" : [ { "x" : 355, "y" : 806 } ] }, { "id" : 117651, "points" : [ { "x" : 424, "y" : 809 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 117649, "points" : [ { "x" : 423, "y" : 718 } ] } ] }, { "id" : 117615, "reactomeId" : 10786871, "displayName" : "SUMOylation of NR3C1 (GR) with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 800, "y" : 549 }, "minX" : 794, "maxX" : 806, "minY" : 525, "maxY" : 569, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 798, "y" : 525 }, "to" : { "x" : 800, "y" : 549 } }, { "from" : { "x" : 800, "y" : 549 }, "to" : { "x" : 801, "y" : 569 } } ], "reactionShape" : { "a" : { "x" : 794, "y" : 543 }, "b" : { "x" : 806, "y" : 555 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 800, "y" : 549 } }, "inputs" : [ { "id" : 117616, "points" : [ { "x" : 775, "y" : 507 } ] }, { "id" : 117617, "points" : [ { "x" : 857, "y" : 505 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 117618, "points" : [ { "x" : 775, "y" : 591 } ] }, { "id" : 117619, "points" : [ { "x" : 863, "y" : 593 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 117617, "points" : [ { "x" : 870, "y" : 505 } ] } ] }, { "id" : 117588, "reactomeId" : 10786761, "displayName" : "PIAS1,2-1 SUMOylates AR with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 160, "y" : 106 }, "minX" : 135, "maxX" : 166, "minY" : 84, "maxY" : 128, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 161, "y" : 84 }, "to" : { "x" : 160, "y" : 106 } }, { "from" : { "x" : 160, "y" : 106 }, "to" : { "x" : 135, "y" : 128 } } ], "reactionShape" : { "a" : { "x" : 154, "y" : 100 }, "b" : { "x" : 166, "y" : 112 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 160, "y" : 106 } }, "inputs" : [ { "id" : 117589, "points" : [ { "x" : 125, "y" : 73 } ] }, { "id" : 117590, "points" : [ { "x" : 199, "y" : 68 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 117591, "points" : [ { "x" : 215, "y" : 175 } ], "stoichiometry" : 2 }, { "id" : 117592, "points" : [ { "x" : 108, "y" : 157 } ] } ], "catalysts" : [ { "id" : 117593, "points" : [ { "x" : 132, "y" : 105 } ] } ] }, { "id" : 117620, "reactomeId" : 10787024, "displayName" : "PIAS1,3 SUMOylates NR5A1 with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 127, "y" : 550 }, "minX" : 121, "maxX" : 133, "minY" : 525, "maxY" : 576, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 128, "y" : 525 }, "to" : { "x" : 127, "y" : 550 } }, { "from" : { "x" : 127, "y" : 550 }, "to" : { "x" : 129, "y" : 576 } } ], "reactionShape" : { "a" : { "x" : 121, "y" : 544 }, "b" : { "x" : 133, "y" : 556 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 127, "y" : 550 } }, "inputs" : [ { "id" : 117621, "points" : [ { "x" : 170, "y" : 504 } ] }, { "id" : 117622, "points" : [ { "x" : 96, "y" : 499 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 117623, "points" : [ { "x" : 96, "y" : 607 } ] }, { "id" : 117624, "points" : [ { "x" : 171, "y" : 605 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 117625, "points" : [ { "x" : 148, "y" : 549 } ] } ] }, { "id" : 117652, "reactomeId" : 10787516, "displayName" : "PIAS2,3,4 SUMOylate RORA with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 659, "y" : 766 }, "minX" : 653, "maxX" : 665, "minY" : 743, "maxY" : 794, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 659, "y" : 743 }, "to" : { "x" : 659, "y" : 766 } }, { "from" : { "x" : 659, "y" : 766 }, "to" : { "x" : 662, "y" : 794 } } ], "reactionShape" : { "a" : { "x" : 653, "y" : 760 }, "b" : { "x" : 665, "y" : 772 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 659, "y" : 766 } }, "inputs" : [ { "id" : 117653, "points" : [ { "x" : 705, "y" : 720 } ] }, { "id" : 117654, "points" : [ { "x" : 624, "y" : 726 } ] } ], "outputs" : [ { "id" : 117655, "points" : [ { "x" : 631, "y" : 814 } ] }, { "id" : 117656, "points" : [ { "x" : 708, "y" : 817 } ] } ], "catalysts" : [ { "id" : 117657, "points" : [ { "x" : 678, "y" : 766 } ] } ] }, { "id" : 117626, "reactomeId" : 10787018, "displayName" : "PIAS1,3 SUMOylates NR5A1 with SUMO2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 258, "y" : 551 }, "minX" : 252, "maxX" : 264, "minY" : 529, "maxY" : 576, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 259, "y" : 529 }, "to" : { "x" : 258, "y" : 551 } }, { "from" : { "x" : 258, "y" : 551 }, "to" : { "x" : 259, "y" : 576 } } ], "reactionShape" : { "a" : { "x" : 252, "y" : 545 }, "b" : { "x" : 264, "y" : 557 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 258, "y" : 551 } }, "inputs" : [ { "id" : 117621, "points" : [ { "x" : 217, "y" : 504 } ] }, { "id" : 117627, "points" : [ { "x" : 291, "y" : 506 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 117628, "points" : [ { "x" : 286, "y" : 602 } ] }, { "id" : 117624, "points" : [ { "x" : 212, "y" : 605 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 117625, "points" : [ { "x" : 231, "y" : 550 } ] } ] }, { "id" : 117658, "reactomeId" : 10787504, "displayName" : "PIAS2,3,4 SUMOylate RORA with SUMO2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 809, "y" : 765 }, "minX" : 803, "maxX" : 815, "minY" : 742, "maxY" : 794, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 810, "y" : 742 }, "to" : { "x" : 809, "y" : 765 } }, { "from" : { "x" : 809, "y" : 765 }, "to" : { "x" : 809, "y" : 794 } } ], "reactionShape" : { "a" : { "x" : 803, "y" : 759 }, "b" : { "x" : 815, "y" : 771 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 809, "y" : 765 } }, "inputs" : [ { "id" : 117653, "points" : [ { "x" : 769, "y" : 720 } ] }, { "id" : 117659, "points" : [ { "x" : 843, "y" : 722 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 117660, "points" : [ { "x" : 834, "y" : 814 } ] }, { "id" : 117656, "points" : [ { "x" : 763, "y" : 817 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 117657, "points" : [ { "x" : 789, "y" : 766 } ] } ] }, { "id" : 117594, "reactomeId" : 10786770, "displayName" : "PIAS1,3 SUMOylate ESR1 with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 286, "y" : 108 }, "minX" : 280, "maxX" : 311, "minY" : 85, "maxY" : 131, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 286, "y" : 85 }, "to" : { "x" : 286, "y" : 108 } }, { "from" : { "x" : 286, "y" : 108 }, "to" : { "x" : 311, "y" : 131 } } ], "reactionShape" : { "a" : { "x" : 280, "y" : 102 }, "b" : { "x" : 292, "y" : 114 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 286, "y" : 108 } }, "inputs" : [ { "id" : 117595, "points" : [ { "x" : 318, "y" : 73 } ] }, { "id" : 117590, "points" : [ { "x" : 249, "y" : 68 } ], "stoichiometry" : 5 } ], "outputs" : [ { "id" : 117591, "points" : [ { "x" : 251, "y" : 175 } ], "stoichiometry" : 5 }, { "id" : 117596, "points" : [ { "x" : 344, "y" : 157 } ] } ], "catalysts" : [ { "id" : 117597, "points" : [ { "x" : 339, "y" : 104 } ] } ] }, { "id" : 117661, "reactomeId" : 10786876, "displayName" : "SUMOylation of RXRA with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1077, "y" : 776 }, "minX" : 1071, "maxX" : 1083, "minY" : 748, "maxY" : 800, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1078, "y" : 748 }, "to" : { "x" : 1077, "y" : 776 } }, { "from" : { "x" : 1077, "y" : 776 }, "to" : { "x" : 1078, "y" : 800 } } ], "reactionShape" : { "a" : { "x" : 1071, "y" : 770 }, "b" : { "x" : 1083, "y" : 782 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1077, "y" : 776 } }, "inputs" : [ { "id" : 117662, "points" : [ { "x" : 1026, "y" : 725 } ] }, { "id" : 117663, "points" : [ { "x" : 1119, "y" : 722 } ] } ], "outputs" : [ { "id" : 117664, "points" : [ { "x" : 1051, "y" : 824 } ] }, { "id" : 117665, "points" : [ { "x" : 1115, "y" : 819 } ] } ], "catalysts" : [ { "id" : 117663, "points" : [ { "x" : 1127, "y" : 722 } ] } ] }, { "id" : 117629, "reactomeId" : 10787583, "displayName" : "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 538, "y" : 547 }, "minX" : 532, "maxX" : 544, "minY" : 521, "maxY" : 573, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 538, "y" : 521 }, "to" : { "x" : 538, "y" : 547 } }, { "from" : { "x" : 538, "y" : 547 }, "to" : { "x" : 537, "y" : 573 } } ], "reactionShape" : { "a" : { "x" : 532, "y" : 541 }, "b" : { "x" : 544, "y" : 553 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 538, "y" : 547 } }, "inputs" : [ { "id" : 117630, "points" : [ { "x" : 510, "y" : 514 } ] }, { "id" : 117631, "points" : [ { "x" : 568, "y" : 511 } ] } ], "outputs" : [ { "id" : 117632, "points" : [ { "x" : 508, "y" : 587 } ] }, { "id" : 117633, "points" : [ { "x" : 577, "y" : 591 } ] } ], "catalysts" : [ { "id" : 117634, "points" : [ { "x" : 513, "y" : 547 } ] } ] }, { "id" : 117598, "reactomeId" : 10787532, "displayName" : "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 751, "y" : 133 }, "minX" : 730, "maxX" : 757, "minY" : 107, "maxY" : 158, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 730, "y" : 107 }, "to" : { "x" : 751, "y" : 133 } }, { "from" : { "x" : 751, "y" : 133 }, "to" : { "x" : 752, "y" : 158 } } ], "reactionShape" : { "a" : { "x" : 745, "y" : 127 }, "b" : { "x" : 757, "y" : 139 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 751, "y" : 133 } }, "inputs" : [ { "id" : 117599, "points" : [ { "x" : 804, "y" : 75 } ] }, { "id" : 117600, "points" : [ { "x" : 695, "y" : 81 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 117601, "points" : [ { "x" : 790, "y" : 170 } ] }, { "id" : 117602, "points" : [ { "x" : 711, "y" : 172 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 117603, "points" : [ { "x" : 716, "y" : 130 } ] } ] } ], "compartments" : [ { "id" : 117680, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 623, "y" : 583 }, "minX" : 0, "maxX" : 1247, "minY" : 0, "maxY" : 1167, "prop" : { "x" : 0, "y" : 0, "width" : 1247, "height" : 1167 }, "textPosition" : { "x" : 13, "y" : 1118 }, "insets" : { "x" : 10, "y" : 10, "width" : 1227, "height" : 1147 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 117588, 117589, 117590, 117591, 117593, 117594, 117595, 117597, 117600, 117603, 117602, 117598, 117599, 117601, 117604, 117605, 117607, 117608, 117606, 117614, 117611, 117613, 117609, 117610, 117615, 117616, 117618, 117617, 117619, 117640, 117679, 117620, 117621, 117624, 117625, 117622, 117626, 117627, 117628, 117629, 117630, 117632, 117631, 117634, 117633, 117635, 117636, 117637, 117639, 117641, 117642, 117646, 117645, 117643, 117647, 117648, 117650, 117649, 117651, 117652, 117653, 117654, 117656, 117658, 117660, 117659, 117661, 117662, 117663, 117665, 117666, 117671, 117667, 117668, 117670, 117672, 117673, 117675, 117677, 117678, 117676, 117657, 117592, 117596, 117612, 117623, 117638, 117644, 117655, 117664, 117669, 117674 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ ], "minX" : 0, "maxX" : 1247, "minY" : 0, "maxY" : 1167, "disease" : false }