{
  "dbId" : 10826975,
  "stableId" : "R-GGA-451927",
  "displayName" : "Interleukin-2 family signaling",
  "nodes" : [ {
    "id" : 21760,
    "reactomeId" : 10763587,
    "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 110,
      "y" : 1035
    },
    "minX" : 45,
    "maxX" : 219,
    "minY" : 998,
    "maxY" : 1066,
    "prop" : {
      "x" : 45,
      "y" : 1004,
      "width" : 130,
      "height" : 62
    },
    "textPosition" : {
      "x" : 56,
      "y" : 989
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 175,
          "y" : 1004
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 175,
          "y" : 1004
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21758,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 178,
          "y" : 1014
        },
        "to" : {
          "x" : 219,
          "y" : 1001
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21761,
    "reactomeId" : 10763589,
    "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP:GRB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 111,
      "y" : 957
    },
    "minX" : 48,
    "maxX" : 180,
    "minY" : 917,
    "maxY" : 991,
    "prop" : {
      "x" : 48,
      "y" : 923,
      "width" : 126,
      "height" : 68
    },
    "textPosition" : {
      "x" : 57,
      "y" : 914
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 174,
          "y" : 923
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 174,
          "y" : 923
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21758,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21763,
    "reactomeId" : 10761186,
    "displayName" : "JAK3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 618,
      "y" : 169
    },
    "minX" : 600,
    "maxX" : 752,
    "minY" : 152,
    "maxY" : 308,
    "prop" : {
      "x" : 600,
      "y" : 158,
      "width" : 36,
      "height" : 23
    },
    "textPosition" : {
      "x" : 601,
      "y" : 159
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 636,
          "y" : 158
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 636,
          "y" : 158
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21762,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 629,
          "y" : 184
        },
        "to" : {
          "x" : 752,
          "y" : 308
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21784,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 639,
          "y" : 174
        },
        "to" : {
          "x" : 721,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21764,
    "reactomeId" : 10756160,
    "displayName" : "PTK2B",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 723,
      "y" : 339
    },
    "minX" : 696,
    "maxX" : 757,
    "minY" : 308,
    "maxY" : 351,
    "prop" : {
      "x" : 696,
      "y" : 328,
      "width" : 55,
      "height" : 23
    },
    "textPosition" : {
      "x" : 700,
      "y" : 329
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 751,
          "y" : 328
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 751,
          "y" : 328
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21762,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 733,
          "y" : 325
        },
        "to" : {
          "x" : 752,
          "y" : 308
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21765,
    "reactomeId" : 10762033,
    "displayName" : "JAK3:PYK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 848,
      "y" : 307
    },
    "minX" : 814,
    "maxX" : 889,
    "minY" : 283,
    "maxY" : 325,
    "prop" : {
      "x" : 814,
      "y" : 289,
      "width" : 69,
      "height" : 36
    },
    "textPosition" : {
      "x" : 814,
      "y" : 304
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 883,
          "y" : 289
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 883,
          "y" : 289
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21762,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21766,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21767,
    "reactomeId" : 10762038,
    "displayName" : "JAK3:p-PYK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 996,
      "y" : 308
    },
    "minX" : 948,
    "maxX" : 1050,
    "minY" : 289,
    "maxY" : 322,
    "prop" : {
      "x" : 948,
      "y" : 295,
      "width" : 96,
      "height" : 27
    },
    "textPosition" : {
      "x" : 956,
      "y" : 301
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1044,
          "y" : 295
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1044,
          "y" : 295
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21766,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21769,
    "reactomeId" : 10813850,
    "displayName" : "IL21",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 886,
      "y" : 17
    },
    "minX" : 869,
    "maxX" : 924,
    "minY" : 0,
    "maxY" : 35,
    "prop" : {
      "x" : 869,
      "y" : 6,
      "width" : 34,
      "height" : 22
    },
    "textPosition" : {
      "x" : 869,
      "y" : 6
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 903,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 903,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21768,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 906,
          "y" : 25
        },
        "to" : {
          "x" : 924,
          "y" : 35
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21770,
    "reactomeId" : 10813856,
    "displayName" : "IL21R:JAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 884,
      "y" : 73
    },
    "minX" : 843,
    "maxX" : 932,
    "minY" : 35,
    "maxY" : 85,
    "prop" : {
      "x" : 843,
      "y" : 61,
      "width" : 83,
      "height" : 24
    },
    "textPosition" : {
      "x" : 849,
      "y" : 64
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 926,
          "y" : 61
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 926,
          "y" : 61
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21768,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 896,
          "y" : 58
        },
        "to" : {
          "x" : 924,
          "y" : 35
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21771,
    "reactomeId" : 10813858,
    "displayName" : "IL21:IL21R:JAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 992,
      "y" : 71
    },
    "minX" : 941,
    "maxX" : 1049,
    "minY" : 53,
    "maxY" : 84,
    "prop" : {
      "x" : 941,
      "y" : 59,
      "width" : 102,
      "height" : 25
    },
    "textPosition" : {
      "x" : 942,
      "y" : 63
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1043,
          "y" : 59
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1043,
          "y" : 59
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21768,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21773,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1124,
      "y" : 181
    },
    "minX" : 1105,
    "maxX" : 1151,
    "minY" : 142,
    "maxY" : 196,
    "prop" : {
      "x" : 1105,
      "y" : 166,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1108,
      "y" : 170
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1138,
          "y" : 171
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1138,
          "y" : 171
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21772,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1134,
          "y" : 163
        },
        "to" : {
          "x" : 1151,
          "y" : 142
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1136,
            "y" : 146
          },
          "b" : {
            "x" : 1148,
            "y" : 158
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1142,
            "y" : 152
          }
        }
      }
    } ]
  }, {
    "id" : 21774,
    "reactomeId" : 10813874,
    "displayName" : "IL21:IL21R:JAK1:IL2RG:JAK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1116,
      "y" : 73
    },
    "minX" : 1065,
    "maxX" : 1173,
    "minY" : 42,
    "maxY" : 142,
    "prop" : {
      "x" : 1065,
      "y" : 48,
      "width" : 102,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1065,
      "y" : 63
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1167,
          "y" : 48
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1167,
          "y" : 48
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21772,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1128,
          "y" : 101
        },
        "to" : {
          "x" : 1151,
          "y" : 142
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21775,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1230,
      "y" : 181
    },
    "minX" : 1200,
    "maxX" : 1253,
    "minY" : 142,
    "maxY" : 196,
    "prop" : {
      "x" : 1209,
      "y" : 166,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1214,
      "y" : 170
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1247,
          "y" : 171
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1247,
          "y" : 171
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21772,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1218,
          "y" : 163
        },
        "to" : {
          "x" : 1200,
          "y" : 142
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1203,
            "y" : 146
          },
          "b" : {
            "x" : 1215,
            "y" : 158
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1209,
            "y" : 152
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1210,
          "y" : 160
        },
        "b" : {
          "x" : 1218,
          "y" : 163
        },
        "c" : {
          "x" : 1217,
          "y" : 155
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1217,
          "y" : 155
        }
      }
    } ]
  }, {
    "id" : 21776,
    "reactomeId" : 10813882,
    "displayName" : "IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1237,
      "y" : 70
    },
    "minX" : 1179,
    "maxX" : 1301,
    "minY" : 39,
    "maxY" : 151,
    "prop" : {
      "x" : 1179,
      "y" : 45,
      "width" : 116,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1187,
      "y" : 46
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1295,
          "y" : 45
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1295,
          "y" : 45
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21772,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1224,
          "y" : 98
        },
        "to" : {
          "x" : 1200,
          "y" : 142
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1224,
          "y" : 106
        },
        "b" : {
          "x" : 1224,
          "y" : 98
        },
        "c" : {
          "x" : 1217,
          "y" : 102
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1217,
          "y" : 102
        }
      }
    }, {
      "edgeId" : 21777,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1254,
          "y" : 98
        },
        "to" : {
          "x" : 1295,
          "y" : 151
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21778,
    "reactomeId" : 10813886,
    "displayName" : "STAT1,STAT3,STAT4,STAT5",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1269,
      "y" : 236
    },
    "minX" : 1220,
    "maxX" : 1318,
    "minY" : 151,
    "maxY" : 254,
    "prop" : {
      "x" : 1220,
      "y" : 218,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1223,
      "y" : 218
    },
    "connectors" : [ {
      "edgeId" : 21777,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1274,
          "y" : 212
        },
        "to" : {
          "x" : 1295,
          "y" : 151
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21779,
    "reactomeId" : 10813888,
    "displayName" : "IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1368,
      "y" : 71
    },
    "minX" : 1310,
    "maxX" : 1432,
    "minY" : 26,
    "maxY" : 150,
    "prop" : {
      "x" : 1310,
      "y" : 32,
      "width" : 116,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1318,
      "y" : 33
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1426,
          "y" : 32
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1426,
          "y" : 32
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21777,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21780,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1387,
          "y" : 113
        },
        "to" : {
          "x" : 1407,
          "y" : 150
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21781,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1378,
      "y" : 187
    },
    "minX" : 1357,
    "maxX" : 1407,
    "minY" : 150,
    "maxY" : 202,
    "prop" : {
      "x" : 1357,
      "y" : 172,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1362,
      "y" : 176
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1394,
          "y" : 177
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1394,
          "y" : 177
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21780,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1389,
          "y" : 169
        },
        "to" : {
          "x" : 1407,
          "y" : 150
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1392,
            "y" : 153
          },
          "b" : {
            "x" : 1404,
            "y" : 165
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1398,
            "y" : 159
          }
        }
      }
    } ]
  }, {
    "id" : 21782,
    "reactomeId" : 10813892,
    "displayName" : "IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1522,
      "y" : 68
    },
    "minX" : 1452,
    "maxX" : 1598,
    "minY" : 4,
    "maxY" : 149,
    "prop" : {
      "x" : 1452,
      "y" : 10,
      "width" : 140,
      "height" : 116
    },
    "textPosition" : {
      "x" : 1452,
      "y" : 35
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1592,
          "y" : 10
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1592,
          "y" : 10
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21780,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1476,
          "y" : 129
        },
        "to" : {
          "x" : 1458,
          "y" : 149
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1474,
          "y" : 137
        },
        "b" : {
          "x" : 1476,
          "y" : 129
        },
        "c" : {
          "x" : 1468,
          "y" : 131
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1468,
          "y" : 131
        }
      }
    } ]
  }, {
    "id" : 21783,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1493,
      "y" : 192
    },
    "minX" : 1458,
    "maxX" : 1515,
    "minY" : 149,
    "maxY" : 207,
    "prop" : {
      "x" : 1473,
      "y" : 177,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1477,
      "y" : 181
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1509,
          "y" : 182
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1509,
          "y" : 182
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21780,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1480,
          "y" : 174
        },
        "to" : {
          "x" : 1458,
          "y" : 149
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1463,
            "y" : 155
          },
          "b" : {
            "x" : 1475,
            "y" : 167
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1469,
            "y" : 161
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1472,
          "y" : 171
        },
        "b" : {
          "x" : 1480,
          "y" : 174
        },
        "c" : {
          "x" : 1478,
          "y" : 166
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1478,
          "y" : 166
        }
      }
    } ]
  }, {
    "id" : 21785,
    "reactomeId" : 9678772,
    "displayName" : "JAK3 inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 784,
      "y" : 247
    },
    "minX" : 721,
    "maxX" : 836,
    "minY" : 203,
    "maxY" : 259,
    "prop" : {
      "x" : 732,
      "y" : 236,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 736,
      "y" : 237
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 21784,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 767,
          "y" : 230
        },
        "to" : {
          "x" : 721,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21786,
    "reactomeId" : 10817579,
    "displayName" : "JAK3:JAK3 inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 769,
      "y" : 167
    },
    "minX" : 697,
    "maxX" : 848,
    "minY" : 150,
    "maxY" : 178,
    "prop" : {
      "x" : 697,
      "y" : 156,
      "width" : 145,
      "height" : 22
    },
    "textPosition" : {
      "x" : 706,
      "y" : 157
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 842,
          "y" : 156
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 842,
          "y" : 156
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21784,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21799,
    "reactomeId" : 10754929,
    "displayName" : "STAT5A",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1472,
      "y" : 820
    },
    "minX" : 1429,
    "maxX" : 1516,
    "minY" : 805,
    "maxY" : 836,
    "prop" : {
      "x" : 1429,
      "y" : 805,
      "width" : 87,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1445,
      "y" : 810
    },
    "connectors" : [ ]
  }, {
    "id" : 21800,
    "reactomeId" : 10761203,
    "displayName" : "IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 112,
      "y" : 834
    },
    "minX" : 50,
    "maxX" : 181,
    "minY" : 794,
    "maxY" : 868,
    "prop" : {
      "x" : 50,
      "y" : 800,
      "width" : 125,
      "height" : 68
    },
    "textPosition" : {
      "x" : 57,
      "y" : 805
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 175,
          "y" : 800
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 175,
          "y" : 800
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 21738,
    "reactomeId" : 10760423,
    "displayName" : "JAK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 205,
      "y" : 109
    },
    "minX" : 187,
    "maxX" : 263,
    "minY" : 89,
    "maxY" : 121,
    "prop" : {
      "x" : 187,
      "y" : 98,
      "width" : 36,
      "height" : 23
    },
    "textPosition" : {
      "x" : 188,
      "y" : 99
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 223,
          "y" : 98
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 223,
          "y" : 98
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21737,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 226,
          "y" : 102
        },
        "to" : {
          "x" : 263,
          "y" : 89
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21739,
    "reactomeId" : 10760739,
    "displayName" : "IL2RB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 207,
      "y" : 69
    },
    "minX" : 186,
    "maxX" : 263,
    "minY" : 52,
    "maxY" : 89,
    "prop" : {
      "x" : 186,
      "y" : 58,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 186,
      "y" : 59
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 228,
          "y" : 58
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 228,
          "y" : 58
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21737,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 231,
          "y" : 76
        },
        "to" : {
          "x" : 263,
          "y" : 89
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21740,
    "reactomeId" : 10760741,
    "displayName" : "IL2RB:JAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 331,
      "y" : 68
    },
    "minX" : 295,
    "maxX" : 374,
    "minY" : 51,
    "maxY" : 80,
    "prop" : {
      "x" : 295,
      "y" : 57,
      "width" : 73,
      "height" : 23
    },
    "textPosition" : {
      "x" : 296,
      "y" : 59
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 368,
          "y" : 57
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 368,
          "y" : 57
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21737,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21742,
    "reactomeId" : 10761178,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 109,
      "y" : 1211
    },
    "minX" : 51,
    "maxX" : 306,
    "minY" : 1174,
    "maxY" : 1402,
    "prop" : {
      "x" : 51,
      "y" : 1179,
      "width" : 116,
      "height" : 65
    },
    "textPosition" : {
      "x" : 51,
      "y" : 1145
    },
    "connectors" : [ {
      "edgeId" : 21741,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 130,
          "y" : 1250
        },
        "to" : {
          "x" : 144,
          "y" : 1265
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21752,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 142,
          "y" : 1250
        },
        "to" : {
          "x" : 306,
          "y" : 1402
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21755,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 173,
          "y" : 1191
        },
        "to" : {
          "x" : 217,
          "y" : 1174
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21743,
    "reactomeId" : 10761180,
    "displayName" : "GRB2:GAB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 291,
      "y" : 1241
    },
    "minX" : 144,
    "maxX" : 340,
    "minY" : 1222,
    "maxY" : 1265,
    "prop" : {
      "x" : 248,
      "y" : 1228,
      "width" : 86,
      "height" : 26
    },
    "textPosition" : {
      "x" : 252,
      "y" : 1233
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 334,
          "y" : 1228
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 334,
          "y" : 1228
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21741,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 245,
          "y" : 1248
        },
        "to" : {
          "x" : 144,
          "y" : 1265
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 188,
            "y" : 1250
          },
          "b" : {
            "x" : 200,
            "y" : 1262
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 194,
            "y" : 1256
          }
        }
      }
    } ]
  }, {
    "id" : 21808,
    "reactomeId" : 10827825,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 504,
      "y" : 1702
    },
    "minX" : 437,
    "maxX" : 571,
    "minY" : 1672,
    "maxY" : 1733,
    "prop" : {
      "x" : 437,
      "y" : 1672,
      "width" : 134,
      "height" : 61
    },
    "textPosition" : {
      "x" : 445,
      "y" : 1681
    },
    "connectors" : [ ]
  }, {
    "id" : 21744,
    "reactomeId" : 10761228,
    "displayName" : "Interleukin receptor compexes with activated Shc:GRB2:GAB2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 109,
      "y" : 1337
    },
    "minX" : 50,
    "maxX" : 169,
    "minY" : 1303,
    "maxY" : 1397,
    "prop" : {
      "x" : 50,
      "y" : 1303,
      "width" : 119,
      "height" : 68
    },
    "textPosition" : {
      "x" : 57,
      "y" : 1299
    },
    "connectors" : [ {
      "edgeId" : 21741,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21745,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 111,
          "y" : 1377
        },
        "to" : {
          "x" : 114,
          "y" : 1397
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21809,
    "reactomeId" : 10828191,
    "displayName" : "Interleukin-9 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 624,
      "y" : 835
    },
    "minX" : 569,
    "maxX" : 680,
    "minY" : 808,
    "maxY" : 863,
    "prop" : {
      "x" : 569,
      "y" : 808,
      "width" : 111,
      "height" : 55
    },
    "textPosition" : {
      "x" : 575,
      "y" : 814
    },
    "connectors" : [ ]
  }, {
    "id" : 21810,
    "reactomeId" : 10828183,
    "displayName" : "Interleukin-15 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 767,
      "y" : 837
    },
    "minX" : 704,
    "maxX" : 831,
    "minY" : 807,
    "maxY" : 867,
    "prop" : {
      "x" : 704,
      "y" : 807,
      "width" : 127,
      "height" : 60
    },
    "textPosition" : {
      "x" : 714,
      "y" : 815
    },
    "connectors" : [ ]
  }, {
    "id" : 21746,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 205,
      "y" : 1372
    },
    "minX" : 114,
    "maxX" : 225,
    "minY" : 1356,
    "maxY" : 1397,
    "prop" : {
      "x" : 186,
      "y" : 1357,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 189,
      "y" : 1362
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 219,
          "y" : 1362
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 219,
          "y" : 1362
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21745,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 183,
          "y" : 1377
        },
        "to" : {
          "x" : 114,
          "y" : 1397
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 142,
            "y" : 1381
          },
          "b" : {
            "x" : 154,
            "y" : 1393
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 148,
            "y" : 1387
          }
        }
      }
    } ]
  }, {
    "id" : 21747,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 205,
      "y" : 1457
    },
    "minX" : 114,
    "maxX" : 226,
    "minY" : 1440,
    "maxY" : 1473,
    "prop" : {
      "x" : 185,
      "y" : 1442,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 188,
      "y" : 1447
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 220,
          "y" : 1447
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 220,
          "y" : 1447
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21745,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 182,
          "y" : 1453
        },
        "to" : {
          "x" : 114,
          "y" : 1440
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 142,
            "y" : 1440
          },
          "b" : {
            "x" : 154,
            "y" : 1452
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 148,
            "y" : 1446
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 174,
          "y" : 1456
        },
        "b" : {
          "x" : 182,
          "y" : 1453
        },
        "c" : {
          "x" : 176,
          "y" : 1448
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 176,
          "y" : 1448
        }
      }
    } ]
  }, {
    "id" : 21748,
    "reactomeId" : 10762013,
    "displayName" : "Interleukin receptor complexes with activated Shc:GRB2:p-GAB2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 115,
      "y" : 1507
    },
    "minX" : 50,
    "maxX" : 180,
    "minY" : 1440,
    "maxY" : 1593,
    "prop" : {
      "x" : 50,
      "y" : 1473,
      "width" : 130,
      "height" : 68
    },
    "textPosition" : {
      "x" : 61,
      "y" : 1469
    },
    "connectors" : [ {
      "edgeId" : 21745,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 114,
          "y" : 1467
        },
        "to" : {
          "x" : 114,
          "y" : 1440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 110,
          "y" : 1460
        },
        "b" : {
          "x" : 114,
          "y" : 1467
        },
        "c" : {
          "x" : 118,
          "y" : 1460
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 118,
          "y" : 1460
        }
      }
    }, {
      "edgeId" : 21749,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 114,
          "y" : 1547
        },
        "to" : {
          "x" : 113,
          "y" : 1593
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21750,
    "reactomeId" : 10761999,
    "displayName" : "p85-containing Class 1A PI3Ks",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 217,
      "y" : 1581
    },
    "minX" : 113,
    "maxX" : 282,
    "minY" : 1562,
    "maxY" : 1600,
    "prop" : {
      "x" : 153,
      "y" : 1562,
      "width" : 129,
      "height" : 38
    },
    "textPosition" : {
      "x" : 164,
      "y" : 1563
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 21749,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 147,
          "y" : 1588
        },
        "to" : {
          "x" : 113,
          "y" : 1593
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 124,
            "y" : 1584
          },
          "b" : {
            "x" : 136,
            "y" : 1596
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 130,
            "y" : 1590
          }
        }
      }
    } ]
  }, {
    "id" : 21751,
    "reactomeId" : 10762025,
    "displayName" : "Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 115,
      "y" : 1691
    },
    "minX" : 50,
    "maxX" : 180,
    "minY" : 1650,
    "maxY" : 1733,
    "prop" : {
      "x" : 50,
      "y" : 1650,
      "width" : 130,
      "height" : 83
    },
    "textPosition" : {
      "x" : 51,
      "y" : 1639
    },
    "connectors" : [ {
      "edgeId" : 21749,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21753,
    "reactomeId" : 10736310,
    "displayName" : "GRB2-1:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 374,
      "y" : 1313
    },
    "minX" : 306,
    "maxX" : 420,
    "minY" : 1290,
    "maxY" : 1402,
    "prop" : {
      "x" : 335,
      "y" : 1296,
      "width" : 79,
      "height" : 35
    },
    "textPosition" : {
      "x" : 346,
      "y" : 1296
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 414,
          "y" : 1296
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 414,
          "y" : 1296
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21752,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 360,
          "y" : 1334
        },
        "to" : {
          "x" : 306,
          "y" : 1402
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 327,
            "y" : 1362
          },
          "b" : {
            "x" : 339,
            "y" : 1374
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 333,
            "y" : 1368
          }
        }
      }
    } ]
  }, {
    "id" : 21754,
    "reactomeId" : 10761232,
    "displayName" : "Interleukin receptor complexes with activated SHC1:GRB2:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 306,
      "y" : 1757
    },
    "minX" : 248,
    "maxX" : 371,
    "minY" : 1713,
    "maxY" : 1795,
    "prop" : {
      "x" : 248,
      "y" : 1719,
      "width" : 117,
      "height" : 76
    },
    "textPosition" : {
      "x" : 253,
      "y" : 1718
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 365,
          "y" : 1719
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 365,
          "y" : 1719
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21752,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21756,
    "reactomeId" : 10763581,
    "displayName" : "SHIP1,2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 290,
      "y" : 1173
    },
    "minX" : 217,
    "maxX" : 317,
    "minY" : 1162,
    "maxY" : 1185,
    "prop" : {
      "x" : 264,
      "y" : 1162,
      "width" : 53,
      "height" : 23
    },
    "textPosition" : {
      "x" : 266,
      "y" : 1156
    },
    "connectors" : [ {
      "edgeId" : 21755,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 258,
          "y" : 1173
        },
        "to" : {
          "x" : 217,
          "y" : 1174
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 231,
            "y" : 1167
          },
          "b" : {
            "x" : 243,
            "y" : 1179
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 237,
            "y" : 1173
          }
        }
      }
    } ]
  }, {
    "id" : 21757,
    "reactomeId" : 10763583,
    "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP1,2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 107,
      "y" : 1121
    },
    "minX" : 49,
    "maxX" : 171,
    "minY" : 1078,
    "maxY" : 1159,
    "prop" : {
      "x" : 49,
      "y" : 1084,
      "width" : 116,
      "height" : 75
    },
    "textPosition" : {
      "x" : 53,
      "y" : 1082
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 165,
          "y" : 1084
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 165,
          "y" : 1084
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21755,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21759,
    "reactomeId" : 10736304,
    "displayName" : "GRB2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 268,
      "y" : 1040
    },
    "minX" : 219,
    "maxX" : 303,
    "minY" : 1001,
    "maxY" : 1051,
    "prop" : {
      "x" : 239,
      "y" : 1029,
      "width" : 58,
      "height" : 22
    },
    "textPosition" : {
      "x" : 247,
      "y" : 1029
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 297,
          "y" : 1029
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 297,
          "y" : 1029
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21758,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 254,
          "y" : 1026
        },
        "to" : {
          "x" : 219,
          "y" : 1001
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 230,
            "y" : 1007
          },
          "b" : {
            "x" : 242,
            "y" : 1019
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 236,
            "y" : 1013
          }
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 21762,
    "reactomeId" : 10762044,
    "displayName" : "PTK2B binds JAK3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 783,
      "y" : 308
    },
    "minX" : 752,
    "maxX" : 811,
    "minY" : 302,
    "maxY" : 314,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 752,
        "y" : 308
      },
      "to" : {
        "x" : 783,
        "y" : 308
      }
    }, {
      "from" : {
        "x" : 783,
        "y" : 308
      },
      "to" : {
        "x" : 811,
        "y" : 307
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 804,
        "y" : 311
      },
      "b" : {
        "x" : 811,
        "y" : 307
      },
      "c" : {
        "x" : 804,
        "y" : 303
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 804,
        "y" : 303
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 783,
        "y" : 308
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 783,
        "y" : 308
      }
    },
    "inputs" : [ {
      "id" : 21763,
      "points" : [ {
        "x" : 629,
        "y" : 184
      } ]
    }, {
      "id" : 21764,
      "points" : [ {
        "x" : 733,
        "y" : 325
      } ]
    } ],
    "outputs" : [ {
      "id" : 21765
    } ]
  }, {
    "id" : 21766,
    "reactomeId" : 10762040,
    "displayName" : "PTK2B is phosphorylated",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 918,
      "y" : 306
    },
    "minX" : 886,
    "maxX" : 945,
    "minY" : 300,
    "maxY" : 312,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 886,
        "y" : 306
      },
      "to" : {
        "x" : 918,
        "y" : 306
      }
    }, {
      "from" : {
        "x" : 918,
        "y" : 306
      },
      "to" : {
        "x" : 945,
        "y" : 306
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 938,
        "y" : 310
      },
      "b" : {
        "x" : 945,
        "y" : 306
      },
      "c" : {
        "x" : 938,
        "y" : 302
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 938,
        "y" : 302
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 912,
        "y" : 300
      },
      "b" : {
        "x" : 924,
        "y" : 312
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 918,
        "y" : 306
      }
    },
    "inputs" : [ {
      "id" : 21765
    } ],
    "outputs" : [ {
      "id" : 21767
    } ]
  }, {
    "id" : 21768,
    "reactomeId" : 10813860,
    "displayName" : "IL21 binds IL21R:JAK1",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 957,
      "y" : 36
    },
    "minX" : 924,
    "maxX" : 979,
    "minY" : 30,
    "maxY" : 56,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 924,
        "y" : 35
      },
      "to" : {
        "x" : 957,
        "y" : 36
      }
    }, {
      "from" : {
        "x" : 957,
        "y" : 36
      },
      "to" : {
        "x" : 979,
        "y" : 56
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 971,
        "y" : 54
      },
      "b" : {
        "x" : 979,
        "y" : 56
      },
      "c" : {
        "x" : 977,
        "y" : 48
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 977,
        "y" : 48
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 951,
        "y" : 30
      },
      "b" : {
        "x" : 963,
        "y" : 42
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 957,
        "y" : 36
      }
    },
    "inputs" : [ {
      "id" : 21769,
      "points" : [ {
        "x" : 906,
        "y" : 25
      } ]
    }, {
      "id" : 21770,
      "points" : [ {
        "x" : 896,
        "y" : 58
      } ]
    } ],
    "outputs" : [ {
      "id" : 21771
    } ]
  }, {
    "id" : 21737,
    "reactomeId" : 10761113,
    "displayName" : "IL2RB binds JAK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 287,
      "y" : 89
    },
    "minX" : 263,
    "maxX" : 306,
    "minY" : 83,
    "maxY" : 95,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 263,
        "y" : 89
      },
      "to" : {
        "x" : 287,
        "y" : 89
      }
    }, {
      "from" : {
        "x" : 287,
        "y" : 89
      },
      "to" : {
        "x" : 306,
        "y" : 83
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 301,
        "y" : 89
      },
      "b" : {
        "x" : 306,
        "y" : 83
      },
      "c" : {
        "x" : 298,
        "y" : 81
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 298,
        "y" : 81
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 287,
        "y" : 89
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 287,
        "y" : 89
      }
    },
    "inputs" : [ {
      "id" : 21738,
      "points" : [ {
        "x" : 226,
        "y" : 102
      } ]
    }, {
      "id" : 21739,
      "points" : [ {
        "x" : 231,
        "y" : 76
      } ]
    } ],
    "outputs" : [ {
      "id" : 21740
    } ]
  }, {
    "id" : 21772,
    "reactomeId" : 10813884,
    "displayName" : "IL21 receptor JAK phosphorylation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1173,
      "y" : 142
    },
    "minX" : 1151,
    "maxX" : 1200,
    "minY" : 136,
    "maxY" : 148,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1151,
        "y" : 142
      },
      "to" : {
        "x" : 1173,
        "y" : 142
      }
    }, {
      "from" : {
        "x" : 1173,
        "y" : 142
      },
      "to" : {
        "x" : 1200,
        "y" : 142
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1167,
        "y" : 136
      },
      "b" : {
        "x" : 1179,
        "y" : 148
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1173,
        "y" : 142
      }
    },
    "inputs" : [ {
      "id" : 21773,
      "points" : [ {
        "x" : 1134,
        "y" : 163
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 21774,
      "points" : [ {
        "x" : 1128,
        "y" : 101
      } ]
    } ],
    "outputs" : [ {
      "id" : 21775,
      "points" : [ {
        "x" : 1218,
        "y" : 163
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 21776,
      "points" : [ {
        "x" : 1224,
        "y" : 98
      } ]
    } ]
  }, {
    "id" : 21741,
    "reactomeId" : 10761230,
    "displayName" : "Phosphorylated SHC1 recruits GRB2:GAB2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 134,
      "y" : 1282
    },
    "minX" : 124,
    "maxX" : 144,
    "minY" : 1265,
    "maxY" : 1297,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 144,
        "y" : 1265
      },
      "to" : {
        "x" : 134,
        "y" : 1282
      }
    }, {
      "from" : {
        "x" : 134,
        "y" : 1282
      },
      "to" : {
        "x" : 124,
        "y" : 1297
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 125,
        "y" : 1289
      },
      "b" : {
        "x" : 124,
        "y" : 1297
      },
      "c" : {
        "x" : 131,
        "y" : 1293
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 131,
        "y" : 1293
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 128,
        "y" : 1276
      },
      "b" : {
        "x" : 140,
        "y" : 1288
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 134,
        "y" : 1282
      }
    },
    "inputs" : [ {
      "id" : 21742,
      "points" : [ {
        "x" : 130,
        "y" : 1250
      } ]
    }, {
      "id" : 21743,
      "points" : [ {
        "x" : 245,
        "y" : 1248
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 21744
    } ]
  }, {
    "id" : 21777,
    "reactomeId" : 10813896,
    "displayName" : "IL21 receptor STAT binding",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1340,
      "y" : 151
    },
    "minX" : 1295,
    "maxX" : 1354,
    "minY" : 113,
    "maxY" : 157,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1295,
        "y" : 151
      },
      "to" : {
        "x" : 1340,
        "y" : 151
      }
    }, {
      "from" : {
        "x" : 1340,
        "y" : 151
      },
      "to" : {
        "x" : 1354,
        "y" : 113
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1355,
        "y" : 121
      },
      "b" : {
        "x" : 1354,
        "y" : 113
      },
      "c" : {
        "x" : 1348,
        "y" : 118
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1348,
        "y" : 118
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1334,
        "y" : 145
      },
      "b" : {
        "x" : 1346,
        "y" : 157
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1340,
        "y" : 151
      }
    },
    "inputs" : [ {
      "id" : 21776,
      "points" : [ {
        "x" : 1254,
        "y" : 98
      } ]
    }, {
      "id" : 21778,
      "points" : [ {
        "x" : 1274,
        "y" : 212
      } ]
    } ],
    "outputs" : [ {
      "id" : 21779
    } ]
  }, {
    "id" : 21745,
    "reactomeId" : 10763484,
    "displayName" : "SHC1 mediates cytokine-induced phosphorylation of GAB2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 114,
      "y" : 1418
    },
    "minX" : 108,
    "maxX" : 120,
    "minY" : 1397,
    "maxY" : 1440,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 114,
        "y" : 1397
      },
      "to" : {
        "x" : 114,
        "y" : 1418
      }
    }, {
      "from" : {
        "x" : 114,
        "y" : 1418
      },
      "to" : {
        "x" : 114,
        "y" : 1440
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 108,
        "y" : 1412
      },
      "b" : {
        "x" : 120,
        "y" : 1424
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 114,
        "y" : 1418
      }
    },
    "inputs" : [ {
      "id" : 21744,
      "points" : [ {
        "x" : 111,
        "y" : 1377
      } ]
    }, {
      "id" : 21746,
      "points" : [ {
        "x" : 183,
        "y" : 1377
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 21747,
      "points" : [ {
        "x" : 182,
        "y" : 1453
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 21748,
      "points" : [ {
        "x" : 114,
        "y" : 1467
      } ]
    } ]
  }, {
    "id" : 21780,
    "reactomeId" : 10813894,
    "displayName" : "IL21 receptor STAT phosphorylation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1429,
      "y" : 150
    },
    "minX" : 1407,
    "maxX" : 1458,
    "minY" : 144,
    "maxY" : 156,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1407,
        "y" : 150
      },
      "to" : {
        "x" : 1429,
        "y" : 150
      }
    }, {
      "from" : {
        "x" : 1429,
        "y" : 150
      },
      "to" : {
        "x" : 1458,
        "y" : 149
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1423,
        "y" : 144
      },
      "b" : {
        "x" : 1435,
        "y" : 156
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1429,
        "y" : 150
      }
    },
    "inputs" : [ {
      "id" : 21779,
      "points" : [ {
        "x" : 1387,
        "y" : 113
      } ]
    }, {
      "id" : 21781,
      "points" : [ {
        "x" : 1389,
        "y" : 169
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 21782,
      "points" : [ {
        "x" : 1476,
        "y" : 129
      } ]
    }, {
      "id" : 21783,
      "points" : [ {
        "x" : 1480,
        "y" : 174
      } ],
      "stoichiometry" : 2
    } ]
  }, {
    "id" : 21749,
    "reactomeId" : 10762027,
    "displayName" : "Gab2 binds the p85 subunit of Class 1A PI3 kinases",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 114,
      "y" : 1623
    },
    "minX" : 108,
    "maxX" : 120,
    "minY" : 1593,
    "maxY" : 1644,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 113,
        "y" : 1593
      },
      "to" : {
        "x" : 114,
        "y" : 1623
      }
    }, {
      "from" : {
        "x" : 114,
        "y" : 1623
      },
      "to" : {
        "x" : 114,
        "y" : 1644
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 110,
        "y" : 1637
      },
      "b" : {
        "x" : 114,
        "y" : 1644
      },
      "c" : {
        "x" : 118,
        "y" : 1637
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 118,
        "y" : 1637
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 108,
        "y" : 1617
      },
      "b" : {
        "x" : 120,
        "y" : 1629
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 114,
        "y" : 1623
      }
    },
    "inputs" : [ {
      "id" : 21750,
      "points" : [ {
        "x" : 147,
        "y" : 1588
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 21748,
      "points" : [ {
        "x" : 114,
        "y" : 1547
      } ]
    } ],
    "outputs" : [ {
      "id" : 21751
    } ]
  }, {
    "id" : 21784,
    "reactomeId" : 10817581,
    "displayName" : "JAK3 binds JAK3 inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 722,
      "y" : 203
    },
    "minX" : 716,
    "maxX" : 754,
    "minY" : 181,
    "maxY" : 209,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 721,
        "y" : 203
      },
      "to" : {
        "x" : 722,
        "y" : 203
      }
    }, {
      "from" : {
        "x" : 722,
        "y" : 203
      },
      "to" : {
        "x" : 754,
        "y" : 181
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 751,
        "y" : 188
      },
      "b" : {
        "x" : 754,
        "y" : 181
      },
      "c" : {
        "x" : 746,
        "y" : 182
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 746,
        "y" : 182
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 722,
        "y" : 203
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 722,
        "y" : 203
      }
    },
    "inputs" : [ {
      "id" : 21785,
      "points" : [ {
        "x" : 767,
        "y" : 230
      } ]
    }, {
      "id" : 21763,
      "points" : [ {
        "x" : 639,
        "y" : 174
      } ]
    } ],
    "outputs" : [ {
      "id" : 21786
    } ]
  }, {
    "id" : 21752,
    "reactomeId" : 10761234,
    "displayName" : "Phosphorylated SHC recruits GRB2:SOS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 307,
      "y" : 1512
    },
    "minX" : 301,
    "maxX" : 313,
    "minY" : 1402,
    "maxY" : 1716,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 306,
        "y" : 1402
      },
      "to" : {
        "x" : 307,
        "y" : 1512
      }
    }, {
      "from" : {
        "x" : 307,
        "y" : 1512
      },
      "to" : {
        "x" : 306,
        "y" : 1716
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 302,
        "y" : 1709
      },
      "b" : {
        "x" : 306,
        "y" : 1716
      },
      "c" : {
        "x" : 310,
        "y" : 1709
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 310,
        "y" : 1709
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 307,
        "y" : 1512
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 307,
        "y" : 1512
      }
    },
    "inputs" : [ {
      "id" : 21742,
      "points" : [ {
        "x" : 142,
        "y" : 1250
      } ]
    }, {
      "id" : 21753,
      "points" : [ {
        "x" : 360,
        "y" : 1334
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 21754
    } ]
  }, {
    "id" : 21755,
    "reactomeId" : 10763585,
    "displayName" : "Phosphorylated SHC1 recruits SHIP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 191,
      "y" : 1159
    },
    "minX" : 168,
    "maxX" : 217,
    "minY" : 1147,
    "maxY" : 1174,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 217,
        "y" : 1174
      },
      "to" : {
        "x" : 191,
        "y" : 1159
      }
    }, {
      "from" : {
        "x" : 191,
        "y" : 1159
      },
      "to" : {
        "x" : 168,
        "y" : 1147
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 176,
        "y" : 1147
      },
      "b" : {
        "x" : 168,
        "y" : 1147
      },
      "c" : {
        "x" : 172,
        "y" : 1154
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 172,
        "y" : 1154
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 191,
        "y" : 1159
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 191,
        "y" : 1159
      }
    },
    "inputs" : [ {
      "id" : 21742,
      "points" : [ {
        "x" : 173,
        "y" : 1191
      } ]
    }, {
      "id" : 21756,
      "points" : [ {
        "x" : 258,
        "y" : 1173
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 21757
    } ]
  }, {
    "id" : 21758,
    "reactomeId" : 10763591,
    "displayName" : "The SHC1:SHIP1 complex is stabilized by GRB2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 220,
      "y" : 972
    },
    "minX" : 177,
    "maxX" : 226,
    "minY" : 965,
    "maxY" : 1001,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 219,
        "y" : 1001
      },
      "to" : {
        "x" : 220,
        "y" : 972
      }
    }, {
      "from" : {
        "x" : 220,
        "y" : 972
      },
      "to" : {
        "x" : 177,
        "y" : 965
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 184,
        "y" : 962
      },
      "b" : {
        "x" : 177,
        "y" : 965
      },
      "c" : {
        "x" : 183,
        "y" : 970
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 183,
        "y" : 970
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 220,
        "y" : 972
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 220,
        "y" : 972
      }
    },
    "inputs" : [ {
      "id" : 21759,
      "points" : [ {
        "x" : 254,
        "y" : 1026
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 21760,
      "points" : [ {
        "x" : 178,
        "y" : 1014
      } ]
    } ],
    "outputs" : [ {
      "id" : 21761
    } ]
  } ],
  "compartments" : [ {
    "id" : 21802,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1189,
      "y" : 1228
    },
    "minX" : 1104,
    "maxX" : 1275,
    "minY" : 1147,
    "maxY" : 1309,
    "prop" : {
      "x" : 1104,
      "y" : 1147,
      "width" : 171,
      "height" : 162
    },
    "textPosition" : {
      "x" : 1120,
      "y" : 1263
    },
    "insets" : {
      "x" : 1114,
      "y" : 1157,
      "width" : 151,
      "height" : 142
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 21787,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 864,
      "y" : 923
    },
    "minX" : 96,
    "maxX" : 1633,
    "minY" : 65,
    "maxY" : 1782,
    "prop" : {
      "x" : 96,
      "y" : 65,
      "width" : 1537,
      "height" : 1717
    },
    "textPosition" : {
      "x" : 455,
      "y" : 1114
    },
    "insets" : {
      "x" : 106,
      "y" : 75,
      "width" : 1517,
      "height" : 1697
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 21737, 21738, 21739, 21740, 21763, 21799, 21800, 21741, 21742, 21744, 21745, 21748, 21749, 21750, 21751, 21752, 21753, 21755, 21756, 21757, 21761, 21758, 21760, 21759, 21762, 21764, 21765, 21766, 21767, 21746, 21747, 21802, 21743, 21754, 21808, 21814, 21770, 21771, 21774, 21772, 21776, 21775, 21773, 21777, 21778, 21815, 21779, 21782, 21780, 21781, 21783, 21809, 21810, 21784, 21785, 21786 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 21813,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 6,
      "y" : 1022
    },
    "minX" : 0,
    "maxX" : 47,
    "minY" : 834,
    "maxY" : 1211,
    "segments" : [ {
      "from" : {
        "x" : 47,
        "y" : 834
      },
      "to" : {
        "x" : 4,
        "y" : 834
      }
    }, {
      "from" : {
        "x" : 4,
        "y" : 834
      },
      "to" : {
        "x" : 8,
        "y" : 1211
      }
    }, {
      "from" : {
        "x" : 8,
        "y" : 1211
      },
      "to" : {
        "x" : 45,
        "y" : 1211
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 0,
        "y" : 1016
      },
      "b" : {
        "x" : 12,
        "y" : 1028
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6,
        "y" : 1022
      }
    },
    "inputs" : [ {
      "id" : 21800
    } ],
    "outputs" : [ {
      "id" : 21742
    } ]
  }, {
    "id" : 21814,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 401,
      "y" : 1730
    },
    "minX" : 368,
    "maxX" : 434,
    "minY" : 1720,
    "maxY" : 1740,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 368,
        "y" : 1740
      },
      "to" : {
        "x" : 434,
        "y" : 1720
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 429,
        "y" : 1726
      },
      "b" : {
        "x" : 434,
        "y" : 1720
      },
      "c" : {
        "x" : 426,
        "y" : 1718
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 426,
        "y" : 1718
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 395,
        "y" : 1724
      },
      "b" : {
        "x" : 407,
        "y" : 1736
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 401,
        "y" : 1730
      }
    },
    "inputs" : [ {
      "id" : 21754
    } ],
    "outputs" : [ {
      "id" : 21808
    } ]
  }, {
    "id" : 21815,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1370,
      "y" : 529
    },
    "minX" : 1275,
    "maxX" : 1466,
    "minY" : 260,
    "maxY" : 799,
    "segments" : [ {
      "from" : {
        "x" : 1275,
        "y" : 260
      },
      "to" : {
        "x" : 1466,
        "y" : 799
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1364,
        "y" : 523
      },
      "b" : {
        "x" : 1376,
        "y" : 535
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1370,
        "y" : 529
      }
    },
    "inputs" : [ {
      "id" : 21778
    } ],
    "outputs" : [ {
      "id" : 21799
    } ]
  } ],
  "shadows" : [ {
    "id" : 21816,
    "reactomeId" : 10826973,
    "displayName" : "Interleukin-2 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 615,
      "y" : 204
    },
    "minX" : 176,
    "maxX" : 1054,
    "minY" : 47,
    "maxY" : 361,
    "prop" : {
      "x" : 176,
      "y" : 47,
      "width" : 657,
      "height" : 217
    },
    "points" : [ {
      "x" : 176,
      "y" : 47
    }, {
      "x" : 1054,
      "y" : 47
    }, {
      "x" : 1054,
      "y" : 361
    }, {
      "x" : 176,
      "y" : 361
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 21817,
    "reactomeId" : 10826977,
    "displayName" : "Interleukin receptor SHC signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 229,
      "y" : 1359
    },
    "minX" : 35,
    "maxX" : 424,
    "minY" : 913,
    "maxY" : 1805,
    "prop" : {
      "x" : 35,
      "y" : 913,
      "width" : 389,
      "height" : 892
    },
    "points" : [ {
      "x" : 35,
      "y" : 913
    }, {
      "x" : 424,
      "y" : 913
    }, {
      "x" : 424,
      "y" : 1805
    }, {
      "x" : 35,
      "y" : 1805
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 21818,
    "reactomeId" : 10828195,
    "displayName" : "Interleukin-21 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1217,
      "y" : 130
    },
    "minX" : 833,
    "maxX" : 1602,
    "minY" : -4,
    "maxY" : 264,
    "prop" : {
      "x" : 1054,
      "y" : 47,
      "width" : 548,
      "height" : 217
    },
    "points" : [ {
      "x" : 833,
      "y" : -4
    }, {
      "x" : 1602,
      "y" : -4
    }, {
      "x" : 1602,
      "y" : 264
    }, {
      "x" : 833,
      "y" : 264
    } ],
    "colour" : "#008000"
  } ],
  "minX" : 0,
  "maxX" : 1633,
  "minY" : 0,
  "maxY" : 1795,
  "disease" : false
}