{ "dbId" : 10826867, "stableId" : "R-GGA-4085001", "displayName" : "Sialic acid metabolism", "nodes" : [ { "id" : 43911, "reactomeId" : 162756, "displayName" : "UDP-GlcNAc", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 163, "y" : 61 }, "minX" : 115, "maxX" : 212, "minY" : 45, "maxY" : 111, "prop" : { "x" : 115, "y" : 46, "width" : 96, "height" : 30 }, "textPosition" : { "x" : 122, "y" : 50 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 206, "y" : 51 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 206, "y" : 51 } } }, "connectors" : [ { "edgeId" : 43910, "type" : "INPUT", "segments" : [ { "from" : { "x" : 162, "y" : 79 }, "to" : { "x" : 162, "y" : 111 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43912, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 99, "y" : 86 }, "minX" : 78, "maxX" : 162, "minY" : 70, "maxY" : 111, "prop" : { "x" : 78, "y" : 71, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 82, "y" : 75 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 115, "y" : 76 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 115, "y" : 76 } } }, "connectors" : [ { "edgeId" : 43910, "type" : "INPUT", "segments" : [ { "from" : { "x" : 123, "y" : 94 }, "to" : { "x" : 162, "y" : 111 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 43913, "reactomeId" : 110096, "displayName" : "UDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 116, "y" : 192 }, "minX" : 95, "maxX" : 162, "minY" : 170, "maxY" : 207, "prop" : { "x" : 95, "y" : 177, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 99, "y" : 181 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 132, "y" : 182 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 132, "y" : 182 } } }, "connectors" : [ { "edgeId" : 43910, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 140, "y" : 181 }, "to" : { "x" : 162, "y" : 170 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 144, "y" : 174 }, "b" : { "x" : 140, "y" : 181 }, "c" : { "x" : 148, "y" : 181 }, "type" : "ARROW", "centre" : { "x" : 148, "y" : 181 } } } ] }, { "id" : 43914, "reactomeId" : 4085214, "displayName" : "ManNAc", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 163, "y" : 221 }, "minX" : 128, "maxX" : 200, "minY" : 170, "maxY" : 275, "prop" : { "x" : 128, "y" : 206, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 134, "y" : 210 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 194, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 194, "y" : 211 } } }, "connectors" : [ { "edgeId" : 43910, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 162, "y" : 203 }, "to" : { "x" : 162, "y" : 170 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 158, "y" : 196 }, "b" : { "x" : 162, "y" : 203 }, "c" : { "x" : 166, "y" : 196 }, "type" : "ARROW", "centre" : { "x" : 166, "y" : 196 } } }, { "edgeId" : 43917, "type" : "INPUT", "segments" : [ { "from" : { "x" : 162, "y" : 239 }, "to" : { "x" : 162, "y" : 275 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43915, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 216, "y" : 190 }, "minX" : 162, "maxX" : 235, "minY" : 170, "maxY" : 205, "prop" : { "x" : 198, "y" : 175, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 202, "y" : 179 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 229, "y" : 180 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 229, "y" : 180 } } }, "connectors" : [ { "edgeId" : 43910, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 195, "y" : 183 }, "to" : { "x" : 162, "y" : 170 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 187, "y" : 184 }, "b" : { "x" : 195, "y" : 183 }, "c" : { "x" : 190, "y" : 177 }, "type" : "ARROW", "centre" : { "x" : 190, "y" : 177 } } } ], "trivial" : true }, { "id" : 43916, "reactomeId" : 10786492, "displayName" : "GNE hexamer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 86, "y" : 137 }, "minX" : 38, "maxX" : 154, "minY" : 120, "maxY" : 304, "prop" : { "x" : 38, "y" : 126, "width" : 96, "height" : 22 }, "textPosition" : { "x" : 40, "y" : 127 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 134, "y" : 126 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 134, "y" : 126 } } }, "connectors" : [ { "edgeId" : 43910, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 137, "y" : 137 }, "to" : { "x" : 146, "y" : 137 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 150, "y" : 138 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 150, "y" : 138 } } }, { "edgeId" : 43917, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 86, "y" : 151 }, "to" : { "x" : 86, "y" : 298 } }, { "from" : { "x" : 86, "y" : 298 }, "to" : { "x" : 146, "y" : 300 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 150, "y" : 300 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 150, "y" : 300 } } } ] }, { "id" : 43918, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 216, "y" : 260 }, "minX" : 162, "maxX" : 238, "minY" : 244, "maxY" : 275, "prop" : { "x" : 195, "y" : 245, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 200, "y" : 249 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 232, "y" : 250 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 232, "y" : 250 } } }, "connectors" : [ { "edgeId" : 43917, "type" : "INPUT", "segments" : [ { "from" : { "x" : 192, "y" : 265 }, "to" : { "x" : 162, "y" : 275 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43919, "reactomeId" : 4085225, "displayName" : "ManNAc-6-P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 162, "y" : 382 }, "minX" : 120, "maxX" : 206, "minY" : 329, "maxY" : 433, "prop" : { "x" : 120, "y" : 367, "width" : 85, "height" : 30 }, "textPosition" : { "x" : 121, "y" : 371 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 200, "y" : 372 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 200, "y" : 372 } } }, "connectors" : [ { "edgeId" : 43917, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 161, "y" : 364 }, "to" : { "x" : 161, "y" : 329 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 157, "y" : 357 }, "b" : { "x" : 161, "y" : 364 }, "c" : { "x" : 165, "y" : 357 }, "type" : "ARROW", "centre" : { "x" : 165, "y" : 357 } } }, { "edgeId" : 43922, "type" : "INPUT", "segments" : [ { "from" : { "x" : 162, "y" : 400 }, "to" : { "x" : 162, "y" : 433 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43920, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 219, "y" : 308 }, "minX" : 161, "maxX" : 241, "minY" : 292, "maxY" : 329, "prop" : { "x" : 198, "y" : 293, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 202, "y" : 297 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 235, "y" : 298 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 235, "y" : 298 } } }, "connectors" : [ { "edgeId" : 43917, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 195, "y" : 315 }, "to" : { "x" : 161, "y" : 329 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 190, "y" : 321 }, "b" : { "x" : 195, "y" : 315 }, "c" : { "x" : 187, "y" : 314 }, "type" : "ARROW", "centre" : { "x" : 187, "y" : 314 } } } ] }, { "id" : 43921, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 218, "y" : 348 }, "minX" : 161, "maxX" : 237, "minY" : 329, "maxY" : 363, "prop" : { "x" : 200, "y" : 333, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 204, "y" : 337 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 231, "y" : 338 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 231, "y" : 338 } } }, "connectors" : [ { "edgeId" : 43917, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 197, "y" : 342 }, "to" : { "x" : 161, "y" : 329 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 189, "y" : 343 }, "b" : { "x" : 197, "y" : 342 }, "c" : { "x" : 192, "y" : 336 }, "type" : "ARROW", "centre" : { "x" : 192, "y" : 336 } } } ], "trivial" : true }, { "id" : 43923, "reactomeId" : 29492, "displayName" : "PEP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 216, "y" : 421 }, "minX" : 162, "maxX" : 236, "minY" : 405, "maxY" : 436, "prop" : { "x" : 197, "y" : 406, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 200, "y" : 410 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 230, "y" : 411 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 230, "y" : 411 } } }, "connectors" : [ { "edgeId" : 43922, "type" : "INPUT", "segments" : [ { "from" : { "x" : 194, "y" : 425 }, "to" : { "x" : 162, "y" : 433 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43924, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 113, "y" : 416 }, "minX" : 92, "maxX" : 162, "minY" : 400, "maxY" : 433, "prop" : { "x" : 92, "y" : 401, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 96, "y" : 405 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 130, "y" : 406 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 130, "y" : 406 } } }, "connectors" : [ { "edgeId" : 43922, "type" : "INPUT", "segments" : [ { "from" : { "x" : 138, "y" : 423 }, "to" : { "x" : 162, "y" : 433 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 43925, "reactomeId" : 4085390, "displayName" : "Neu5Ac-9-P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 161, "y" : 570 }, "minX" : 116, "maxX" : 208, "minY" : 516, "maxY" : 623, "prop" : { "x" : 116, "y" : 555, "width" : 91, "height" : 30 }, "textPosition" : { "x" : 121, "y" : 559 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 202, "y" : 560 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 202, "y" : 560 } } }, "connectors" : [ { "edgeId" : 43922, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 161, "y" : 552 }, "to" : { "x" : 161, "y" : 516 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 157, "y" : 545 }, "b" : { "x" : 161, "y" : 552 }, "c" : { "x" : 165, "y" : 545 }, "type" : "ARROW", "centre" : { "x" : 165, "y" : 545 } } }, { "edgeId" : 43928, "type" : "INPUT", "segments" : [ { "from" : { "x" : 160, "y" : 588 }, "to" : { "x" : 160, "y" : 623 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43926, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 114, "y" : 534 }, "minX" : 101, "maxX" : 161, "minY" : 516, "maxY" : 549, "prop" : { "x" : 101, "y" : 519, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 105, "y" : 523 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 123, "y" : 524 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 123, "y" : 524 } } }, "connectors" : [ { "edgeId" : 43922, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 131, "y" : 528 }, "to" : { "x" : 161, "y" : 516 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 136, "y" : 522 }, "b" : { "x" : 131, "y" : 528 }, "c" : { "x" : 139, "y" : 529 }, "type" : "ARROW", "centre" : { "x" : 139, "y" : 529 } } } ] }, { "id" : 43927, "reactomeId" : 10786420, "displayName" : "NANS", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 105, "y" : 474 }, "minX" : 85, "maxX" : 153, "minY" : 457, "maxY" : 485, "prop" : { "x" : 85, "y" : 463, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 88, "y" : 457 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 126, "y" : 463 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 126, "y" : 463 } } }, "connectors" : [ { "edgeId" : 43922, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 129, "y" : 474 }, "to" : { "x" : 145, "y" : 475 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 149, "y" : 475 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 149, "y" : 475 } } } ] }, { "id" : 43929, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 209, "y" : 607 }, "minX" : 160, "maxX" : 232, "minY" : 591, "maxY" : 623, "prop" : { "x" : 188, "y" : 592, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 192, "y" : 596 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 226, "y" : 597 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 226, "y" : 597 } } }, "connectors" : [ { "edgeId" : 43928, "type" : "INPUT", "segments" : [ { "from" : { "x" : 185, "y" : 614 }, "to" : { "x" : 160, "y" : 623 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 43930, "reactomeId" : 428633, "displayName" : "Neu5Ac", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 160, "y" : 733 }, "minX" : 129, "maxX" : 192, "minY" : 694, "maxY" : 748, "prop" : { "x" : 129, "y" : 718, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 132, "y" : 722 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 186, "y" : 723 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 186, "y" : 723 } } }, "connectors" : [ { "edgeId" : 43928, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 160, "y" : 715 }, "to" : { "x" : 160, "y" : 694 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 156, "y" : 708 }, "b" : { "x" : 160, "y" : 715 }, "c" : { "x" : 164, "y" : 708 }, "type" : "ARROW", "centre" : { "x" : 164, "y" : 708 } } } ] }, { "id" : 43931, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 208, "y" : 702 }, "minX" : 160, "maxX" : 223, "minY" : 686, "maxY" : 717, "prop" : { "x" : 195, "y" : 687, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 199, "y" : 691 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 217, "y" : 692 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 217, "y" : 692 } } }, "connectors" : [ { "edgeId" : 43928, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 192, "y" : 699 }, "to" : { "x" : 160, "y" : 694 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 185, "y" : 702 }, "b" : { "x" : 192, "y" : 699 }, "c" : { "x" : 186, "y" : 694 }, "type" : "ARROW", "centre" : { "x" : 186, "y" : 694 } } } ] }, { "id" : 43932, "reactomeId" : 10786481, "displayName" : "NANP:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 77, "y" : 661 }, "minX" : 37, "maxX" : 152, "minY" : 644, "maxY" : 672, "prop" : { "x" : 37, "y" : 650, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 54, "y" : 637 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 118, "y" : 650 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 118, "y" : 650 } } }, "connectors" : [ { "edgeId" : 43928, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 121, "y" : 661 }, "to" : { "x" : 144, "y" : 661 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 148, "y" : 661 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 148, "y" : 661 } } } ] }, { "id" : 43934, "reactomeId" : 4085414, "displayName" : "Neu5Ac", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 333, "y" : 733 }, "minX" : 302, "maxX" : 367, "minY" : 717, "maxY" : 766, "prop" : { "x" : 302, "y" : 718, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 305, "y" : 722 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 359, "y" : 723 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 359, "y" : 723 } } }, "connectors" : [ { "edgeId" : 43933, "type" : "INPUT", "segments" : [ { "from" : { "x" : 348, "y" : 751 }, "to" : { "x" : 367, "y" : 766 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43935, "reactomeId" : 29470, "displayName" : "CTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 319, "y" : 787 }, "minX" : 299, "maxX" : 367, "minY" : 766, "maxY" : 802, "prop" : { "x" : 299, "y" : 772, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 303, "y" : 776 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 334, "y" : 777 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 334, "y" : 777 } } }, "connectors" : [ { "edgeId" : 43933, "type" : "INPUT", "segments" : [ { "from" : { "x" : 342, "y" : 778 }, "to" : { "x" : 367, "y" : 766 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43936, "reactomeId" : 113541, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 497, "y" : 792 }, "minX" : 442, "maxX" : 517, "minY" : 766, "maxY" : 807, "prop" : { "x" : 479, "y" : 777, "width" : 37, "height" : 30 }, "textPosition" : { "x" : 484, "y" : 781 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 511, "y" : 782 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 511, "y" : 782 } } }, "connectors" : [ { "edgeId" : 43933, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 476, "y" : 783 }, "to" : { "x" : 442, "y" : 766 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 468, "y" : 783 }, "b" : { "x" : 476, "y" : 783 }, "c" : { "x" : 472, "y" : 776 }, "type" : "ARROW", "centre" : { "x" : 472, "y" : 776 } } } ] }, { "id" : 43937, "reactomeId" : 4085418, "displayName" : "CMP-Neu5Ac", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 503, "y" : 733 }, "minX" : 442, "maxX" : 551, "minY" : 716, "maxY" : 766, "prop" : { "x" : 456, "y" : 717, "width" : 94, "height" : 32 }, "textPosition" : { "x" : 460, "y" : 722 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 545, "y" : 722 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 545, "y" : 722 } } }, "connectors" : [ { "edgeId" : 43933, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 473, "y" : 752 }, "to" : { "x" : 442, "y" : 766 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 468, "y" : 758 }, "b" : { "x" : 473, "y" : 752 }, "c" : { "x" : 465, "y" : 751 }, "type" : "ARROW", "centre" : { "x" : 465, "y" : 751 } } } ] }, { "id" : 43938, "reactomeId" : 10786463, "displayName" : "CMAS tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 397, "y" : 815 }, "minX" : 345, "maxX" : 455, "minY" : 774, "maxY" : 826, "prop" : { "x" : 345, "y" : 804, "width" : 104, "height" : 22 }, "textPosition" : { "x" : 346, "y" : 805 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 449, "y" : 804 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 449, "y" : 804 } } }, "connectors" : [ { "edgeId" : 43933, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 397, "y" : 801 }, "to" : { "x" : 397, "y" : 782 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 397, "y" : 778 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 397, "y" : 778 } } } ] }, { "id" : 43940, "reactomeId" : 4085435, "displayName" : "CMP-Neu5Ac", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 502, "y" : 565 }, "minX" : 455, "maxX" : 550, "minY" : 509, "maxY" : 580, "prop" : { "x" : 455, "y" : 550, "width" : 94, "height" : 30 }, "textPosition" : { "x" : 459, "y" : 554 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 544, "y" : 555 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 544, "y" : 555 } } }, "connectors" : [ { "edgeId" : 43939, "type" : "INPUT", "segments" : [ { "from" : { "x" : 501, "y" : 547 }, "to" : { "x" : 499, "y" : 509 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43941, "reactomeId" : 727810, "displayName" : "CMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 502, "y" : 465 }, "minX" : 481, "maxX" : 524, "minY" : 449, "maxY" : 509, "prop" : { "x" : 481, "y" : 450, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 485, "y" : 454 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 518, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 518, "y" : 455 } } }, "connectors" : [ { "edgeId" : 43939, "type" : "INPUT", "segments" : [ { "from" : { "x" : 500, "y" : 483 }, "to" : { "x" : 499, "y" : 509 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43942, "reactomeId" : 727815, "displayName" : "CMP-Neu5Ac", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 401, "y" : 214 }, "minX" : 350, "maxX" : 503, "minY" : 143, "maxY" : 519, "prop" : { "x" : 354, "y" : 199, "width" : 94, "height" : 30 }, "textPosition" : { "x" : 358, "y" : 203 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 443, "y" : 204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 443, "y" : 204 } } }, "connectors" : [ { "edgeId" : 43939, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 396, "y" : 232 }, "to" : { "x" : 350, "y" : 378 } }, { "from" : { "x" : 350, "y" : 378 }, "to" : { "x" : 478, "y" : 519 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 398, "y" : 240 }, "b" : { "x" : 396, "y" : 232 }, "c" : { "x" : 390, "y" : 237 }, "type" : "ARROW", "centre" : { "x" : 390, "y" : 237 } } }, { "edgeId" : 43945, "type" : "INPUT", "segments" : [ { "from" : { "x" : 451, "y" : 214 }, "to" : { "x" : 503, "y" : 214 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 43950, "type" : "INPUT", "segments" : [ { "from" : { "x" : 419, "y" : 196 }, "to" : { "x" : 488, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 43953, "type" : "INPUT", "segments" : [ { "from" : { "x" : 419, "y" : 232 }, "to" : { "x" : 485, "y" : 283 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 43958, "type" : "INPUT", "segments" : [ { "from" : { "x" : 405, "y" : 232 }, "to" : { "x" : 435, "y" : 338 } }, { "from" : { "x" : 435, "y" : 338 }, "to" : { "x" : 496, "y" : 361 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43943, "reactomeId" : 109395, "displayName" : "CMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 405, "y" : 571 }, "minX" : 384, "maxX" : 478, "minY" : 519, "maxY" : 586, "prop" : { "x" : 384, "y" : 556, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 388, "y" : 560 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 421, "y" : 561 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 421, "y" : 561 } } }, "connectors" : [ { "edgeId" : 43939, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 429, "y" : 556 }, "to" : { "x" : 478, "y" : 519 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 432, "y" : 549 }, "b" : { "x" : 429, "y" : 556 }, "c" : { "x" : 437, "y" : 555 }, "type" : "ARROW", "centre" : { "x" : 437, "y" : 555 } } } ] }, { "id" : 43944, "reactomeId" : 10762541, "displayName" : "SLC35A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 384, "y" : 508 }, "minX" : 354, "maxX" : 441, "minY" : 491, "maxY" : 519, "prop" : { "x" : 354, "y" : 497, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 357, "y" : 491 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 415, "y" : 497 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 415, "y" : 497 } } }, "connectors" : [ { "edgeId" : 43939, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 418, "y" : 508 }, "to" : { "x" : 433, "y" : 508 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 437, "y" : 509 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 437, "y" : 509 } } } ] }, { "id" : 43946, "reactomeId" : 4086285, "displayName" : "Gal-R", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 396, "y" : 144 }, "minX" : 371, "maxX" : 503, "minY" : 128, "maxY" : 214, "prop" : { "x" : 371, "y" : 129, "width" : 51, "height" : 30 }, "textPosition" : { "x" : 376, "y" : 133 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 417, "y" : 134 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 417, "y" : 134 } } }, "connectors" : [ { "edgeId" : 43945, "type" : "INPUT", "segments" : [ { "from" : { "x" : 418, "y" : 162 }, "to" : { "x" : 503, "y" : 214 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 43950, "type" : "INPUT", "segments" : [ { "from" : { "x" : 425, "y" : 143 }, "to" : { "x" : 488, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43947, "reactomeId" : 4086277, "displayName" : "Neu5Ac-2,3-Gal-R", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 698, "y" : 215 }, "minX" : 586, "maxX" : 764, "minY" : 199, "maxY" : 230, "prop" : { "x" : 633, "y" : 200, "width" : 130, "height" : 30 }, "textPosition" : { "x" : 640, "y" : 204 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 758, "y" : 205 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 758, "y" : 205 } } }, "connectors" : [ { "edgeId" : 43945, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 630, "y" : 214 }, "to" : { "x" : 586, "y" : 214 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 623, "y" : 218 }, "b" : { "x" : 630, "y" : 214 }, "c" : { "x" : 623, "y" : 210 }, "type" : "ARROW", "centre" : { "x" : 623, "y" : 210 } } } ] }, { "id" : 43948, "reactomeId" : 727810, "displayName" : "CMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 611, "y" : 181 }, "minX" : 583, "maxX" : 633, "minY" : 143, "maxY" : 214, "prop" : { "x" : 590, "y" : 166, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 594, "y" : 170 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 627, "y" : 171 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 627, "y" : 171 } } }, "connectors" : [ { "edgeId" : 43945, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 599, "y" : 199 }, "to" : { "x" : 586, "y" : 214 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 597, "y" : 207 }, "b" : { "x" : 599, "y" : 199 }, "c" : { "x" : 591, "y" : 202 }, "type" : "ARROW", "centre" : { "x" : 591, "y" : 202 } } }, { "edgeId" : 43950, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 599, "y" : 163 }, "to" : { "x" : 583, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 592, "y" : 160 }, "b" : { "x" : 599, "y" : 163 }, "c" : { "x" : 598, "y" : 155 }, "type" : "ARROW", "centre" : { "x" : 598, "y" : 155 } } } ] }, { "id" : 43949, "reactomeId" : 10786472, "displayName" : "ST3GAL1-6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 535, "y" : 172 }, "minX" : 497, "maxX" : 574, "minY" : 161, "maxY" : 206, "prop" : { "x" : 497, "y" : 161, "width" : 77, "height" : 22 }, "textPosition" : { "x" : 498, "y" : 161 }, "connectors" : [ { "edgeId" : 43945, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 535, "y" : 189 }, "to" : { "x" : 535, "y" : 198 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 535, "y" : 202 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 535, "y" : 202 } } } ] }, { "id" : 43951, "reactomeId" : 4086294, "displayName" : "Neu5Ac-2,6-Gal-R", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 699, "y" : 143 }, "minX" : 583, "maxX" : 765, "minY" : 127, "maxY" : 158, "prop" : { "x" : 634, "y" : 128, "width" : 130, "height" : 30 }, "textPosition" : { "x" : 641, "y" : 132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 759, "y" : 133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 759, "y" : 133 } } }, "connectors" : [ { "edgeId" : 43950, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 631, "y" : 143 }, "to" : { "x" : 583, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 624, "y" : 147 }, "b" : { "x" : 631, "y" : 143 }, "c" : { "x" : 624, "y" : 139 }, "type" : "ARROW", "centre" : { "x" : 624, "y" : 139 } } } ] }, { "id" : 43952, "reactomeId" : 10786506, "displayName" : "ST6GAL1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 534, "y" : 99 }, "minX" : 497, "maxX" : 571, "minY" : 88, "maxY" : 135, "prop" : { "x" : 497, "y" : 88, "width" : 74, "height" : 22 }, "textPosition" : { "x" : 497, "y" : 88 }, "connectors" : [ { "edgeId" : 43950, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 534, "y" : 116 }, "to" : { "x" : 534, "y" : 127 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 534, "y" : 131 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 534, "y" : 131 } } } ] }, { "id" : 43954, "reactomeId" : 4086301, "displayName" : "GalNAc-R", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 470, "y" : 316 }, "minX" : 433, "maxX" : 508, "minY" : 283, "maxY" : 331, "prop" : { "x" : 433, "y" : 301, "width" : 74, "height" : 30 }, "textPosition" : { "x" : 438, "y" : 305 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 502, "y" : 306 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 502, "y" : 306 } } }, "connectors" : [ { "edgeId" : 43953, "type" : "INPUT", "segments" : [ { "from" : { "x" : 476, "y" : 298 }, "to" : { "x" : 485, "y" : 283 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43955, "reactomeId" : 4086341, "displayName" : "Neu5Ac-2,6-GalNAc-R", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 717, "y" : 284 }, "minX" : 625, "maxX" : 766, "minY" : 261, "maxY" : 306, "prop" : { "x" : 669, "y" : 262, "width" : 96, "height" : 44 }, "textPosition" : { "x" : 675, "y" : 266 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 760, "y" : 267 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 760, "y" : 267 } } }, "connectors" : [ { "edgeId" : 43953, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 666, "y" : 283 }, "to" : { "x" : 625, "y" : 283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 659, "y" : 287 }, "b" : { "x" : 666, "y" : 283 }, "c" : { "x" : 659, "y" : 279 }, "type" : "ARROW", "centre" : { "x" : 659, "y" : 279 } } } ] }, { "id" : 43956, "reactomeId" : 727810, "displayName" : "CMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 662, "y" : 326 }, "minX" : 625, "maxX" : 684, "minY" : 283, "maxY" : 361, "prop" : { "x" : 641, "y" : 311, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 645, "y" : 315 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 678, "y" : 316 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 678, "y" : 316 } } }, "connectors" : [ { "edgeId" : 43953, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 649, "y" : 308 }, "to" : { "x" : 625, "y" : 283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 641, "y" : 306 }, "b" : { "x" : 649, "y" : 308 }, "c" : { "x" : 647, "y" : 300 }, "type" : "ARROW", "centre" : { "x" : 647, "y" : 300 } } }, { "edgeId" : 43958, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 647, "y" : 344 }, "to" : { "x" : 627, "y" : 361 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 644, "y" : 352 }, "b" : { "x" : 647, "y" : 344 }, "c" : { "x" : 639, "y" : 345 }, "type" : "ARROW", "centre" : { "x" : 639, "y" : 345 } } } ] }, { "id" : 43957, "reactomeId" : 10786454, "displayName" : "ST6GALNAC1-6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 534, "y" : 240 }, "minX" : 483, "maxX" : 585, "minY" : 229, "maxY" : 275, "prop" : { "x" : 483, "y" : 229, "width" : 102, "height" : 22 }, "textPosition" : { "x" : 484, "y" : 229 }, "connectors" : [ { "edgeId" : 43953, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 534, "y" : 257 }, "to" : { "x" : 534, "y" : 267 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 535, "y" : 271 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 535, "y" : 271 } } } ] }, { "id" : 43959, "reactomeId" : 4088006, "displayName" : "Neu5Ac-R", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 450, "y" : 404 }, "minX" : 412, "maxX" : 496, "minY" : 361, "maxY" : 419, "prop" : { "x" : 412, "y" : 389, "width" : 77, "height" : 30 }, "textPosition" : { "x" : 416, "y" : 393 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 484, "y" : 394 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 484, "y" : 394 } } }, "connectors" : [ { "edgeId" : 43958, "type" : "INPUT", "segments" : [ { "from" : { "x" : 466, "y" : 386 }, "to" : { "x" : 496, "y" : 361 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43960, "reactomeId" : 4087982, "displayName" : "Neu5Ac-2,8-Neu5Ac-R", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 745, "y" : 362 }, "minX" : 627, "maxX" : 794, "minY" : 339, "maxY" : 384, "prop" : { "x" : 697, "y" : 340, "width" : 96, "height" : 44 }, "textPosition" : { "x" : 703, "y" : 344 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 788, "y" : 345 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 788, "y" : 345 } } }, "connectors" : [ { "edgeId" : 43958, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 694, "y" : 361 }, "to" : { "x" : 627, "y" : 361 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 687, "y" : 365 }, "b" : { "x" : 694, "y" : 361 }, "c" : { "x" : 687, "y" : 357 }, "type" : "ARROW", "centre" : { "x" : 687, "y" : 357 } } } ] }, { "id" : 43961, "reactomeId" : 10786437, "displayName" : "ST8SIA1-6", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 552, "y" : 322 }, "minX" : 517, "maxX" : 588, "minY" : 311, "maxY" : 353, "prop" : { "x" : 517, "y" : 311, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 517, "y" : 311 }, "connectors" : [ { "edgeId" : 43958, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 552, "y" : 339 }, "to" : { "x" : 552, "y" : 345 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 552, "y" : 349 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 552, "y" : 349 } } } ] }, { "id" : 43963, "reactomeId" : 4088088, "displayName" : "NEU3 substrates", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1165, "y" : 23 }, "minX" : 1109, "maxX" : 1222, "minY" : 8, "maxY" : 84, "prop" : { "x" : 1109, "y" : 8, "width" : 113, "height" : 30 }, "textPosition" : { "x" : 1127, "y" : 6 }, "connectors" : [ { "edgeId" : 43962, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1164, "y" : 44 }, "to" : { "x" : 1164, "y" : 84 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43964, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1207, "y" : 61 }, "minX" : 1164, "maxX" : 1230, "minY" : 45, "maxY" : 84, "prop" : { "x" : 1186, "y" : 46, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1190, "y" : 50 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1224, "y" : 51 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1224, "y" : 51 } } }, "connectors" : [ { "edgeId" : 43962, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1183, "y" : 72 }, "to" : { "x" : 1164, "y" : 84 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 43965, "reactomeId" : 4088103, "displayName" : "Gal-R, Neu5Ac-R", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1260, "y" : 175 }, "minX" : 1164, "maxX" : 1320, "minY" : 149, "maxY" : 190, "prop" : { "x" : 1201, "y" : 160, "width" : 119, "height" : 30 }, "textPosition" : { "x" : 1206, "y" : 164 }, "connectors" : [ { "edgeId" : 43962, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1202, "y" : 154 }, "to" : { "x" : 1164, "y" : 150 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1195, "y" : 157 }, "b" : { "x" : 1202, "y" : 154 }, "c" : { "x" : 1196, "y" : 149 }, "type" : "ARROW", "centre" : { "x" : 1196, "y" : 149 } } } ] }, { "id" : 43966, "reactomeId" : 428633, "displayName" : "Neu5Ac", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1164, "y" : 211 }, "minX" : 1133, "maxX" : 1196, "minY" : 150, "maxY" : 226, "prop" : { "x" : 1133, "y" : 196, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 1136, "y" : 200 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1190, "y" : 201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1190, "y" : 201 } } }, "connectors" : [ { "edgeId" : 43962, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1164, "y" : 193 }, "to" : { "x" : 1164, "y" : 150 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1160, "y" : 186 }, "b" : { "x" : 1164, "y" : 193 }, "c" : { "x" : 1168, "y" : 186 }, "type" : "ARROW", "centre" : { "x" : 1168, "y" : 186 } } } ] }, { "id" : 43967, "reactomeId" : 10773392, "displayName" : "NEU3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1106, "y" : 112 }, "minX" : 1086, "maxX" : 1156, "minY" : 95, "maxY" : 123, "prop" : { "x" : 1086, "y" : 101, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 1089, "y" : 95 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1127, "y" : 101 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1127, "y" : 101 } } }, "connectors" : [ { "edgeId" : 43962, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1130, "y" : 112 }, "to" : { "x" : 1148, "y" : 112 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1152, "y" : 112 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1152, "y" : 112 } } } ] }, { "id" : 43969, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1030, "y" : 525 }, "minX" : 1009, "maxX" : 1163, "minY" : 509, "maxY" : 540, "prop" : { "x" : 1009, "y" : 510, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1013, "y" : 514 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1047, "y" : 515 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1047, "y" : 515 } } }, "connectors" : [ { "edgeId" : 43968, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1055, "y" : 527 }, "to" : { "x" : 1163, "y" : 540 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 43970, "reactomeId" : 4088202, "displayName" : "glycoconjugates", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 847, "y" : 585 }, "minX" : 793, "maxX" : 1163, "minY" : 540, "maxY" : 600, "prop" : { "x" : 793, "y" : 570, "width" : 108, "height" : 30 }, "textPosition" : { "x" : 795, "y" : 568 }, "connectors" : [ { "edgeId" : 43968, "type" : "INPUT", "segments" : [ { "from" : { "x" : 907, "y" : 577 }, "to" : { "x" : 1163, "y" : 540 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43971, "reactomeId" : 4088123, "displayName" : "Gal-R,GalNAc-R,Neu5Ac-R", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1299, "y" : 489 }, "minX" : 1241, "maxX" : 1357, "minY" : 467, "maxY" : 540, "prop" : { "x" : 1241, "y" : 467, "width" : 116, "height" : 44 }, "textPosition" : { "x" : 1247, "y" : 471 }, "connectors" : [ { "edgeId" : 43968, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1276, "y" : 517 }, "to" : { "x" : 1246, "y" : 540 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1273, "y" : 524 }, "b" : { "x" : 1276, "y" : 517 }, "c" : { "x" : 1268, "y" : 518 }, "type" : "ARROW", "centre" : { "x" : 1268, "y" : 518 } } } ] }, { "id" : 43972, "reactomeId" : 428633, "displayName" : "Neu5Ac", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1345, "y" : 605 }, "minX" : 1246, "maxX" : 1377, "minY" : 540, "maxY" : 802, "prop" : { "x" : 1314, "y" : 590, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 1317, "y" : 594 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1371, "y" : 595 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1371, "y" : 595 } } }, "connectors" : [ { "edgeId" : 43968, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1322, "y" : 587 }, "to" : { "x" : 1246, "y" : 540 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1314, "y" : 587 }, "b" : { "x" : 1322, "y" : 587 }, "c" : { "x" : 1318, "y" : 580 }, "type" : "ARROW", "centre" : { "x" : 1318, "y" : 580 } } }, { "edgeId" : 43974, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1338, "y" : 623 }, "to" : { "x" : 1257, "y" : 802 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1339, "y" : 631 }, "b" : { "x" : 1338, "y" : 623 }, "c" : { "x" : 1331, "y" : 628 }, "type" : "ARROW", "centre" : { "x" : 1331, "y" : 628 } } } ] }, { "id" : 43973, "reactomeId" : 10773365, "displayName" : "NEU2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1195, "y" : 492 }, "minX" : 1175, "maxX" : 1222, "minY" : 475, "maxY" : 532, "prop" : { "x" : 1175, "y" : 481, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 1178, "y" : 475 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1216, "y" : 481 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1216, "y" : 481 } } }, "connectors" : [ { "edgeId" : 43968, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1195, "y" : 506 }, "to" : { "x" : 1196, "y" : 524 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1196, "y" : 528 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1196, "y" : 528 } } } ] }, { "id" : 43975, "reactomeId" : 428639, "displayName" : "Neu5Ac", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1153, "y" : 760 }, "minX" : 1122, "maxX" : 1185, "minY" : 744, "maxY" : 802, "prop" : { "x" : 1122, "y" : 745, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 1125, "y" : 749 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1179, "y" : 750 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1179, "y" : 750 } } }, "connectors" : [ { "edgeId" : 43974, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1157, "y" : 778 }, "to" : { "x" : 1165, "y" : 802 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43976, "reactomeId" : 428040, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1136, "y" : 833 }, "minX" : 1118, "maxX" : 1165, "minY" : 802, "maxY" : 848, "prop" : { "x" : 1118, "y" : 818, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1122, "y" : 822 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1149, "y" : 823 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1149, "y" : 823 } } }, "connectors" : [ { "edgeId" : 43974, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1150, "y" : 815 }, "to" : { "x" : 1165, "y" : 802 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 43977, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1302, "y" : 842 }, "minX" : 1257, "maxX" : 1321, "minY" : 802, "maxY" : 857, "prop" : { "x" : 1284, "y" : 827, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1288, "y" : 831 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1315, "y" : 832 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1315, "y" : 832 } } }, "connectors" : [ { "edgeId" : 43974, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1285, "y" : 824 }, "to" : { "x" : 1257, "y" : 802 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1277, "y" : 823 }, "b" : { "x" : 1285, "y" : 824 }, "c" : { "x" : 1282, "y" : 817 }, "type" : "ARROW", "centre" : { "x" : 1282, "y" : 817 } } } ], "trivial" : true }, { "id" : 43978, "reactomeId" : 10758463, "displayName" : "SLC17A5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1216, "y" : 848 }, "minX" : 1186, "maxX" : 1253, "minY" : 810, "maxY" : 859, "prop" : { "x" : 1186, "y" : 837, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 1189, "y" : 831 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1247, "y" : 837 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1247, "y" : 837 } } }, "connectors" : [ { "edgeId" : 43974, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1216, "y" : 834 }, "to" : { "x" : 1216, "y" : 818 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1216, "y" : 814 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1216, "y" : 814 } } } ] }, { "id" : 43980, "reactomeId" : 4088096, "displayName" : "Neu5Ac, Neu5Gc", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1473, "y" : 605 }, "minX" : 1415, "maxX" : 1531, "minY" : 590, "maxY" : 620, "prop" : { "x" : 1415, "y" : 590, "width" : 116, "height" : 30 }, "textPosition" : { "x" : 1416, "y" : 594 }, "connectors" : [ { "edgeId" : 43979, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 43981, "reactomeId" : 29398, "displayName" : "PYR", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1440, "y" : 771 }, "minX" : 1421, "maxX" : 1472, "minY" : 707, "maxY" : 786, "prop" : { "x" : 1421, "y" : 756, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1425, "y" : 760 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1455, "y" : 761 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1455, "y" : 761 } } }, "connectors" : [ { "edgeId" : 43979, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1447, "y" : 753 }, "to" : { "x" : 1472, "y" : 707 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1447, "y" : 745 }, "b" : { "x" : 1447, "y" : 753 }, "c" : { "x" : 1454, "y" : 749 }, "type" : "ARROW", "centre" : { "x" : 1454, "y" : 749 } } } ] }, { "id" : 43982, "reactomeId" : 4088099, "displayName" : "ManNAc,ManNGc", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1549, "y" : 770 }, "minX" : 1472, "maxX" : 1607, "minY" : 707, "maxY" : 785, "prop" : { "x" : 1491, "y" : 755, "width" : 116, "height" : 30 }, "textPosition" : { "x" : 1492, "y" : 759 }, "connectors" : [ { "edgeId" : 43979, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1530, "y" : 749 }, "to" : { "x" : 1472, "y" : 707 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1522, "y" : 748 }, "b" : { "x" : 1530, "y" : 749 }, "c" : { "x" : 1527, "y" : 742 }, "type" : "ARROW", "centre" : { "x" : 1527, "y" : 742 } } } ] }, { "id" : 43983, "reactomeId" : 10786553, "displayName" : "NPL tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1562, "y" : 672 }, "minX" : 1480, "maxX" : 1611, "minY" : 655, "maxY" : 683, "prop" : { "x" : 1520, "y" : 661, "width" : 85, "height" : 22 }, "textPosition" : { "x" : 1531, "y" : 648 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1605, "y" : 661 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1605, "y" : 661 } } }, "connectors" : [ { "edgeId" : 43979, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1517, "y" : 672 }, "to" : { "x" : 1488, "y" : 672 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1484, "y" : 672 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1484, "y" : 672 } } } ] }, { "id" : 43989, "reactomeId" : 10826861, "displayName" : "Sphingolipid metabolism", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1349, "y" : 22 }, "minX" : 1307, "maxX" : 1392, "minY" : 0, "maxY" : 45, "prop" : { "x" : 1307, "y" : 0, "width" : 85, "height" : 45 }, "textPosition" : { "x" : 1307, "y" : -13 }, "connectors" : [ ] } ], "edges" : [ { "id" : 43968, "reactomeId" : 10786500, "displayName" : "NEU2 hydrolyzes Neu5Ac from glycoconjugates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1196, "y" : 540 }, "minX" : 1163, "maxX" : 1246, "minY" : 534, "maxY" : 546, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1163, "y" : 540 }, "to" : { "x" : 1196, "y" : 540 } }, { "from" : { "x" : 1196, "y" : 540 }, "to" : { "x" : 1246, "y" : 540 } } ], "reactionShape" : { "a" : { "x" : 1190, "y" : 534 }, "b" : { "x" : 1202, "y" : 546 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1196, "y" : 540 } }, "inputs" : [ { "id" : 43969, "points" : [ { "x" : 1055, "y" : 527 } ] }, { "id" : 43970, "points" : [ { "x" : 907, "y" : 577 } ] } ], "outputs" : [ { "id" : 43971, "points" : [ { "x" : 1276, "y" : 517 } ] }, { "id" : 43972, "points" : [ { "x" : 1322, "y" : 587 } ] } ], "catalysts" : [ { "id" : 43973, "points" : [ { "x" : 1195, "y" : 506 } ] } ] }, { "id" : 43939, "reactomeId" : 10762544, "displayName" : "SLC35A1 exchanges CMP-Neu5Ac for CMP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 449, "y" : 509 }, "minX" : 443, "maxX" : 499, "minY" : 503, "maxY" : 519, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 499, "y" : 509 }, "to" : { "x" : 449, "y" : 509 } }, { "from" : { "x" : 449, "y" : 509 }, "to" : { "x" : 478, "y" : 519 } } ], "reactionShape" : { "a" : { "x" : 443, "y" : 503 }, "b" : { "x" : 455, "y" : 515 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 449, "y" : 509 } }, "inputs" : [ { "id" : 43940, "points" : [ { "x" : 501, "y" : 547 } ] }, { "id" : 43941, "points" : [ { "x" : 500, "y" : 483 } ] } ], "outputs" : [ { "id" : 43942, "points" : [ { "x" : 396, "y" : 232 }, { "x" : 350, "y" : 378 } ] }, { "id" : 43943, "points" : [ { "x" : 429, "y" : 556 } ] } ], "catalysts" : [ { "id" : 43944, "points" : [ { "x" : 418, "y" : 508 } ] } ] }, { "id" : 43974, "reactomeId" : 10758466, "displayName" : "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1216, "y" : 802 }, "minX" : 1165, "maxX" : 1257, "minY" : 796, "maxY" : 808, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1165, "y" : 802 }, "to" : { "x" : 1216, "y" : 802 } }, { "from" : { "x" : 1216, "y" : 802 }, "to" : { "x" : 1257, "y" : 802 } } ], "reactionShape" : { "a" : { "x" : 1210, "y" : 796 }, "b" : { "x" : 1222, "y" : 808 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1216, "y" : 802 } }, "inputs" : [ { "id" : 43975, "points" : [ { "x" : 1157, "y" : 778 } ] }, { "id" : 43976, "points" : [ { "x" : 1150, "y" : 815 } ] } ], "outputs" : [ { "id" : 43972, "points" : [ { "x" : 1338, "y" : 623 } ] }, { "id" : 43977, "points" : [ { "x" : 1285, "y" : 824 } ] } ], "catalysts" : [ { "id" : 43978, "points" : [ { "x" : 1216, "y" : 834 } ] } ] }, { "id" : 43910, "reactomeId" : 10786495, "displayName" : "GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 162, "y" : 138 }, "minX" : 156, "maxX" : 168, "minY" : 111, "maxY" : 170, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 162, "y" : 111 }, "to" : { "x" : 162, "y" : 138 } }, { "from" : { "x" : 162, "y" : 138 }, "to" : { "x" : 162, "y" : 170 } } ], "reactionShape" : { "a" : { "x" : 156, "y" : 132 }, "b" : { "x" : 168, "y" : 144 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 162, "y" : 138 } }, "inputs" : [ { "id" : 43911, "points" : [ { "x" : 162, "y" : 79 } ] }, { "id" : 43912, "points" : [ { "x" : 123, "y" : 94 } ] } ], "outputs" : [ { "id" : 43913, "points" : [ { "x" : 140, "y" : 181 } ] }, { "id" : 43914, "points" : [ { "x" : 162, "y" : 203 } ] }, { "id" : 43915, "points" : [ { "x" : 195, "y" : 183 } ] } ], "catalysts" : [ { "id" : 43916, "points" : [ { "x" : 137, "y" : 137 } ] } ] }, { "id" : 43945, "reactomeId" : 10786475, "displayName" : "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 535, "y" : 214 }, "minX" : 503, "maxX" : 586, "minY" : 208, "maxY" : 220, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 503, "y" : 214 }, "to" : { "x" : 535, "y" : 214 } }, { "from" : { "x" : 535, "y" : 214 }, "to" : { "x" : 586, "y" : 214 } } ], "reactionShape" : { "a" : { "x" : 529, "y" : 208 }, "b" : { "x" : 541, "y" : 220 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 535, "y" : 214 } }, "inputs" : [ { "id" : 43942, "points" : [ { "x" : 451, "y" : 214 } ] }, { "id" : 43946, "points" : [ { "x" : 418, "y" : 162 } ] } ], "outputs" : [ { "id" : 43947, "points" : [ { "x" : 630, "y" : 214 } ] }, { "id" : 43948, "points" : [ { "x" : 599, "y" : 199 } ] } ], "catalysts" : [ { "id" : 43949, "points" : [ { "x" : 535, "y" : 189 } ] } ] }, { "id" : 43979, "reactomeId" : 10786556, "displayName" : "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1472, "y" : 672 }, "minX" : 1466, "maxX" : 1478, "minY" : 626, "maxY" : 707, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1472, "y" : 626 }, "to" : { "x" : 1472, "y" : 672 } }, { "from" : { "x" : 1472, "y" : 672 }, "to" : { "x" : 1472, "y" : 707 } } ], "reactionShape" : { "a" : { "x" : 1466, "y" : 666 }, "b" : { "x" : 1478, "y" : 678 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1472, "y" : 672 } }, "inputs" : [ { "id" : 43980 } ], "outputs" : [ { "id" : 43981, "points" : [ { "x" : 1447, "y" : 753 } ] }, { "id" : 43982, "points" : [ { "x" : 1530, "y" : 749 } ] } ], "catalysts" : [ { "id" : 43983, "points" : [ { "x" : 1517, "y" : 672 } ] } ] }, { "id" : 43917, "reactomeId" : 10786498, "displayName" : "GNE phosphorylates ManNAc to ManNAc-6-P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 162, "y" : 300 }, "minX" : 156, "maxX" : 168, "minY" : 275, "maxY" : 329, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 162, "y" : 275 }, "to" : { "x" : 162, "y" : 300 } }, { "from" : { "x" : 162, "y" : 300 }, "to" : { "x" : 161, "y" : 329 } } ], "reactionShape" : { "a" : { "x" : 156, "y" : 294 }, "b" : { "x" : 168, "y" : 306 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 162, "y" : 300 } }, "inputs" : [ { "id" : 43918, "points" : [ { "x" : 192, "y" : 265 } ] }, { "id" : 43914, "points" : [ { "x" : 162, "y" : 239 } ] } ], "outputs" : [ { "id" : 43919, "points" : [ { "x" : 161, "y" : 364 } ] }, { "id" : 43920, "points" : [ { "x" : 195, "y" : 315 } ] }, { "id" : 43921, "points" : [ { "x" : 197, "y" : 342 } ] } ], "catalysts" : [ { "id" : 43916, "points" : [ { "x" : 86, "y" : 151 }, { "x" : 86, "y" : 298 } ] } ] }, { "id" : 43950, "reactomeId" : 10786509, "displayName" : "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 534, "y" : 143 }, "minX" : 488, "maxX" : 583, "minY" : 137, "maxY" : 149, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 488, "y" : 143 }, "to" : { "x" : 534, "y" : 143 } }, { "from" : { "x" : 534, "y" : 143 }, "to" : { "x" : 583, "y" : 143 } } ], "reactionShape" : { "a" : { "x" : 528, "y" : 137 }, "b" : { "x" : 540, "y" : 149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 534, "y" : 143 } }, "inputs" : [ { "id" : 43942, "points" : [ { "x" : 419, "y" : 196 } ] }, { "id" : 43946, "points" : [ { "x" : 425, "y" : 143 } ] } ], "outputs" : [ { "id" : 43951, "points" : [ { "x" : 631, "y" : 143 } ] }, { "id" : 43948, "points" : [ { "x" : 599, "y" : 163 } ] } ], "catalysts" : [ { "id" : 43952, "points" : [ { "x" : 534, "y" : 116 } ] } ] }, { "id" : 43953, "reactomeId" : 10786457, "displayName" : "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 535, "y" : 283 }, "minX" : 485, "maxX" : 625, "minY" : 277, "maxY" : 289, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 485, "y" : 283 }, "to" : { "x" : 535, "y" : 283 } }, { "from" : { "x" : 535, "y" : 283 }, "to" : { "x" : 625, "y" : 283 } } ], "reactionShape" : { "a" : { "x" : 529, "y" : 277 }, "b" : { "x" : 541, "y" : 289 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 535, "y" : 283 } }, "inputs" : [ { "id" : 43942, "points" : [ { "x" : 419, "y" : 232 } ] }, { "id" : 43954, "points" : [ { "x" : 476, "y" : 298 } ] } ], "outputs" : [ { "id" : 43955, "points" : [ { "x" : 666, "y" : 283 } ] }, { "id" : 43956, "points" : [ { "x" : 649, "y" : 308 } ] } ], "catalysts" : [ { "id" : 43957, "points" : [ { "x" : 534, "y" : 257 } ] } ] }, { "id" : 43922, "reactomeId" : 10786423, "displayName" : "NANS converts ManNAc-6-P to Neu5Ac-9-P", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 161, "y" : 475 }, "minX" : 155, "maxX" : 167, "minY" : 433, "maxY" : 516, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 162, "y" : 433 }, "to" : { "x" : 161, "y" : 475 } }, { "from" : { "x" : 161, "y" : 475 }, "to" : { "x" : 161, "y" : 516 } } ], "reactionShape" : { "a" : { "x" : 155, "y" : 469 }, "b" : { "x" : 167, "y" : 481 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 161, "y" : 475 } }, "inputs" : [ { "id" : 43919, "points" : [ { "x" : 162, "y" : 400 } ] }, { "id" : 43923, "points" : [ { "x" : 194, "y" : 425 } ] }, { "id" : 43924, "points" : [ { "x" : 138, "y" : 423 } ] } ], "outputs" : [ { "id" : 43925, "points" : [ { "x" : 161, "y" : 552 } ] }, { "id" : 43926, "points" : [ { "x" : 131, "y" : 528 } ] } ], "catalysts" : [ { "id" : 43927, "points" : [ { "x" : 129, "y" : 474 } ] } ] }, { "id" : 43958, "reactomeId" : 10786440, "displayName" : "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 553, "y" : 361 }, "minX" : 496, "maxX" : 627, "minY" : 355, "maxY" : 367, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 496, "y" : 361 }, "to" : { "x" : 553, "y" : 361 } }, { "from" : { "x" : 553, "y" : 361 }, "to" : { "x" : 627, "y" : 361 } } ], "reactionShape" : { "a" : { "x" : 547, "y" : 355 }, "b" : { "x" : 559, "y" : 367 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 553, "y" : 361 } }, "inputs" : [ { "id" : 43942, "points" : [ { "x" : 405, "y" : 232 }, { "x" : 435, "y" : 338 } ] }, { "id" : 43959, "points" : [ { "x" : 466, "y" : 386 } ] } ], "outputs" : [ { "id" : 43960, "points" : [ { "x" : 694, "y" : 361 } ] }, { "id" : 43956, "points" : [ { "x" : 647, "y" : 344 } ] } ], "catalysts" : [ { "id" : 43961, "points" : [ { "x" : 552, "y" : 339 } ] } ] }, { "id" : 43928, "reactomeId" : 10786484, "displayName" : "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 160, "y" : 661 }, "minX" : 154, "maxX" : 166, "minY" : 623, "maxY" : 694, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 160, "y" : 623 }, "to" : { "x" : 160, "y" : 661 } }, { "from" : { "x" : 160, "y" : 661 }, "to" : { "x" : 160, "y" : 694 } } ], "reactionShape" : { "a" : { "x" : 154, "y" : 655 }, "b" : { "x" : 166, "y" : 667 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 160, "y" : 661 } }, "inputs" : [ { "id" : 43925, "points" : [ { "x" : 160, "y" : 588 } ] }, { "id" : 43929, "points" : [ { "x" : 185, "y" : 614 } ] } ], "outputs" : [ { "id" : 43930, "points" : [ { "x" : 160, "y" : 715 } ] }, { "id" : 43931, "points" : [ { "x" : 192, "y" : 699 } ] } ], "catalysts" : [ { "id" : 43932, "points" : [ { "x" : 121, "y" : 661 } ] } ] }, { "id" : 43962, "reactomeId" : 10786486, "displayName" : "NEU3 hydrolyzes Neu5Ac from glycoconjugates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1164, "y" : 112 }, "minX" : 1158, "maxX" : 1170, "minY" : 84, "maxY" : 150, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1164, "y" : 84 }, "to" : { "x" : 1164, "y" : 112 } }, { "from" : { "x" : 1164, "y" : 112 }, "to" : { "x" : 1164, "y" : 150 } } ], "reactionShape" : { "a" : { "x" : 1158, "y" : 106 }, "b" : { "x" : 1170, "y" : 118 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1164, "y" : 112 } }, "inputs" : [ { "id" : 43963, "points" : [ { "x" : 1164, "y" : 44 } ] }, { "id" : 43964, "points" : [ { "x" : 1183, "y" : 72 } ] } ], "outputs" : [ { "id" : 43965, "points" : [ { "x" : 1202, "y" : 154 } ] }, { "id" : 43966, "points" : [ { "x" : 1164, "y" : 193 } ] } ], "catalysts" : [ { "id" : 43967, "points" : [ { "x" : 1130, "y" : 112 } ] } ] }, { "id" : 43933, "reactomeId" : 10786466, "displayName" : "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 397, "y" : 766 }, "minX" : 367, "maxX" : 442, "minY" : 760, "maxY" : 772, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 367, "y" : 766 }, "to" : { "x" : 397, "y" : 766 } }, { "from" : { "x" : 397, "y" : 766 }, "to" : { "x" : 442, "y" : 766 } } ], "reactionShape" : { "a" : { "x" : 391, "y" : 760 }, "b" : { "x" : 403, "y" : 772 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 397, "y" : 766 } }, "inputs" : [ { "id" : 43934, "points" : [ { "x" : 348, "y" : 751 } ] }, { "id" : 43935, "points" : [ { "x" : 342, "y" : 778 } ] } ], "outputs" : [ { "id" : 43936, "points" : [ { "x" : 476, "y" : 783 } ] }, { "id" : 43937, "points" : [ { "x" : 473, "y" : 752 } ] } ], "catalysts" : [ { "id" : 43938, "points" : [ { "x" : 397, "y" : 801 } ] } ] } ], "compartments" : [ { "id" : 43984, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 843, "y" : 475 }, "minX" : 0, "maxX" : 1686, "minY" : 17, "maxY" : 934, "prop" : { "x" : 0, "y" : 17, "width" : 1686, "height" : 917 }, "textPosition" : { "x" : 632, "y" : 568 }, "insets" : { "x" : 10, "y" : 27, "width" : 1666, "height" : 897 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 43910, 43911, 43912, 43916, 43922, 43925, 43926, 43927, 43928, 43929, 43930, 43932, 43931, 43985, 43913, 43914, 43917, 43918, 43919, 43920, 43923, 43924, 43940, 43986, 43943, 43962, 43963, 43994, 43964, 43965, 43967, 43966, 43970, 43987, 43968, 43971, 43973, 43972, 43977, 43979, 43980, 43981, 43982, 43983, 43995, 43996, 43969, 43989, 43997, 43915, 43921 ] }, { "id" : 43985, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 430, "y" : 771 }, "minX" : 240, "maxX" : 620, "minY" : 657, "maxY" : 886, "prop" : { "x" : 240, "y" : 657, "width" : 380, "height" : 229 }, "textPosition" : { "x" : 514, "y" : 841 }, "insets" : { "x" : 250, "y" : 667, "width" : 360, "height" : 209 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 43934, 43933, 43936, 43937, 43938, 43935 ] }, { "id" : 43986, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 612, "y" : 278 }, "minX" : 321, "maxX" : 903, "minY" : 42, "maxY" : 515, "prop" : { "x" : 321, "y" : 42, "width" : 582, "height" : 473 }, "textPosition" : { "x" : 651, "y" : 466 }, "insets" : { "x" : 331, "y" : 52, "width" : 562, "height" : 453 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 43939, 43941, 43942, 43944, 43945, 43946, 43947, 43949, 43948, 43950, 43951, 43952, 43953, 43954, 43955, 43957, 43956, 43958, 43959, 43960, 43961, 43990, 43991, 43992, 43993 ] }, { "id" : 43987, "reactomeId" : 161320, "displayName" : "lysosomal lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 996, "y" : 747 }, "minX" : 772, "maxX" : 1220, "minY" : 624, "maxY" : 870, "prop" : { "x" : 772, "y" : 624, "width" : 448, "height" : 246 }, "textPosition" : { "x" : 785, "y" : 825 }, "insets" : { "x" : 782, "y" : 634, "width" : 428, "height" : 226 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 43975, 43974, 43976, 43978 ] } ], "notes" : [ ], "links" : [ { "id" : 43995, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1394, "y" : 604 }, "minX" : 1379, "maxX" : 1409, "minY" : 598, "maxY" : 610, "segments" : [ { "from" : { "x" : 1379, "y" : 604 }, "to" : { "x" : 1409, "y" : 604 } } ], "reactionShape" : { "a" : { "x" : 1388, "y" : 598 }, "b" : { "x" : 1400, "y" : 610 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1394, "y" : 604 } }, "inputs" : [ { "id" : 43972 } ], "outputs" : [ { "id" : 43980 } ] }, { "id" : 43996, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1318, "y" : 406 }, "minX" : 1175, "maxX" : 1461, "minY" : 229, "maxY" : 584, "segments" : [ { "from" : { "x" : 1175, "y" : 229 }, "to" : { "x" : 1461, "y" : 584 } } ], "reactionShape" : { "a" : { "x" : 1312, "y" : 400 }, "b" : { "x" : 1324, "y" : 412 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1318, "y" : 406 } }, "inputs" : [ { "id" : 43966 } ], "outputs" : [ { "id" : 43980 } ] }, { "id" : 43997, "renderableClass" : "Interaction", "position" : { "x" : 1301, "y" : 101 }, "minX" : 1268, "maxX" : 1335, "minY" : 48, "maxY" : 154, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1268, "y" : 154 }, "to" : { "x" : 1335, "y" : 48 } } ], "endShape" : { "a" : { "x" : 1335, "y" : 56 }, "b" : { "x" : 1335, "y" : 48 }, "c" : { "x" : 1328, "y" : 52 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1328, "y" : 52 } }, "reactionShape" : { "a" : { "x" : 1295, "y" : 95 }, "b" : { "x" : 1307, "y" : 107 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1301, "y" : 101 } }, "inputs" : [ { "id" : 43965 } ], "outputs" : [ { "id" : 43989 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1686, "minY" : 0, "maxY" : 934, "disease" : false }