{
  "dbId" : 10826833,
  "stableId" : "R-GGA-425410",
  "displayName" : "Metal ion SLC transporters",
  "nodes" : [ {
    "id" : 17054,
    "reactomeId" : 9970133,
    "displayName" : "Cu1+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 265,
      "y" : 812
    },
    "minX" : 243,
    "maxX" : 289,
    "minY" : 796,
    "maxY" : 828,
    "prop" : {
      "x" : 243,
      "y" : 797,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 244,
      "y" : 802
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 283,
          "y" : 802
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 283,
          "y" : 802
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17053,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17055,
    "reactomeId" : 3299744,
    "displayName" : "Cu1+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 263,
      "y" : 673
    },
    "minX" : 241,
    "maxX" : 287,
    "minY" : 657,
    "maxY" : 689,
    "prop" : {
      "x" : 241,
      "y" : 658,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 242,
      "y" : 663
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 281,
          "y" : 663
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 281,
          "y" : 663
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17053,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17056,
    "reactomeId" : 10759475,
    "displayName" : "SLC31A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 350,
      "y" : 752
    },
    "minX" : 272,
    "maxX" : 390,
    "minY" : 731,
    "maxY" : 767,
    "prop" : {
      "x" : 316,
      "y" : 737,
      "width" : 68,
      "height" : 30
    },
    "textPosition" : {
      "x" : 319,
      "y" : 741
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 384,
          "y" : 737
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 384,
          "y" : 737
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17053,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 313,
          "y" : 753
        },
        "to" : {
          "x" : 280,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 276,
          "y" : 755
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 276,
          "y" : 755
        }
      }
    } ]
  }, {
    "id" : 17058,
    "reactomeId" : 114632,
    "displayName" : "Mg2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 438,
      "y" : 807
    },
    "minX" : 418,
    "maxX" : 459,
    "minY" : 789,
    "maxY" : 825,
    "prop" : {
      "x" : 418,
      "y" : 790,
      "width" : 40,
      "height" : 35
    },
    "textPosition" : {
      "x" : 421,
      "y" : 790
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 453,
          "y" : 795
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 453,
          "y" : 795
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17057,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17059,
    "reactomeId" : 29926,
    "displayName" : "Mg2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 438,
      "y" : 679
    },
    "minX" : 420,
    "maxX" : 458,
    "minY" : 659,
    "maxY" : 698,
    "prop" : {
      "x" : 420,
      "y" : 660,
      "width" : 37,
      "height" : 38
    },
    "textPosition" : {
      "x" : 421,
      "y" : 661
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 452,
          "y" : 665
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 452,
          "y" : 665
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17057,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17060,
    "reactomeId" : 10759613,
    "displayName" : "SLC41A1,2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 525,
      "y" : 755
    },
    "minX" : 445,
    "maxX" : 562,
    "minY" : 740,
    "maxY" : 770,
    "prop" : {
      "x" : 488,
      "y" : 740,
      "width" : 74,
      "height" : 30
    },
    "textPosition" : {
      "x" : 488,
      "y" : 744
    },
    "connectors" : [ {
      "edgeId" : 17057,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 482,
          "y" : 753
        },
        "to" : {
          "x" : 453,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 449,
          "y" : 752
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 449,
          "y" : 752
        }
      }
    } ]
  }, {
    "id" : 17062,
    "reactomeId" : 351626,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 206,
      "y" : 87
    },
    "minX" : 192,
    "maxX" : 251,
    "minY" : 72,
    "maxY" : 137,
    "prop" : {
      "x" : 192,
      "y" : 73,
      "width" : 28,
      "height" : 29
    },
    "textPosition" : {
      "x" : 192,
      "y" : 77
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 215,
          "y" : 78
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 215,
          "y" : 78
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17061,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 219,
          "y" : 105
        },
        "to" : {
          "x" : 251,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17063,
    "reactomeId" : 435347,
    "displayName" : "Fe2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 285,
      "y" : 18
    },
    "minX" : 251,
    "maxX" : 306,
    "minY" : 0,
    "maxY" : 137,
    "prop" : {
      "x" : 265,
      "y" : 1,
      "width" : 40,
      "height" : 34
    },
    "textPosition" : {
      "x" : 269,
      "y" : 1
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 300,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 300,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17061,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 280,
          "y" : 38
        },
        "to" : {
          "x" : 251,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17064,
    "reactomeId" : 71067,
    "displayName" : "Fe2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 328,
      "y" : 208
    },
    "minX" : 251,
    "maxX" : 349,
    "minY" : 138,
    "maxY" : 224,
    "prop" : {
      "x" : 309,
      "y" : 192,
      "width" : 39,
      "height" : 32
    },
    "textPosition" : {
      "x" : 313,
      "y" : 191
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 343,
          "y" : 197
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 343,
          "y" : 197
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17061,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 310,
          "y" : 189
        },
        "to" : {
          "x" : 251,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 302,
          "y" : 187
        },
        "b" : {
          "x" : 310,
          "y" : 189
        },
        "c" : {
          "x" : 307,
          "y" : 181
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 307,
          "y" : 181
        }
      }
    } ]
  }, {
    "id" : 17065,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 199,
      "y" : 230
    },
    "minX" : 178,
    "maxX" : 251,
    "minY" : 138,
    "maxY" : 306,
    "prop" : {
      "x" : 184,
      "y" : 217,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 185,
      "y" : 219
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 209,
          "y" : 222
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 209,
          "y" : 222
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17061,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 206,
          "y" : 214
        },
        "to" : {
          "x" : 251,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 206,
          "y" : 206
        },
        "b" : {
          "x" : 206,
          "y" : 214
        },
        "c" : {
          "x" : 213,
          "y" : 210
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 213,
          "y" : 210
        }
      }
    }, {
      "edgeId" : 17079,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 195,
          "y" : 246
        },
        "to" : {
          "x" : 178,
          "y" : 306
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 197,
          "y" : 254
        },
        "b" : {
          "x" : 195,
          "y" : 246
        },
        "c" : {
          "x" : 189,
          "y" : 252
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 189,
          "y" : 252
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17066,
    "reactomeId" : 10759429,
    "displayName" : "SLC11A2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 175,
      "y" : 136
    },
    "minX" : 144,
    "maxX" : 241,
    "minY" : 117,
    "maxY" : 150,
    "prop" : {
      "x" : 144,
      "y" : 123,
      "width" : 62,
      "height" : 27
    },
    "textPosition" : {
      "x" : 144,
      "y" : 126
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 206,
          "y" : 123
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 206,
          "y" : 123
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17061,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 209,
          "y" : 136
        },
        "to" : {
          "x" : 233,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 237,
          "y" : 137
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 237,
          "y" : 137
        }
      }
    } ]
  }, {
    "id" : 17068,
    "reactomeId" : 71067,
    "displayName" : "Fe2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 459,
      "y" : 215
    },
    "minX" : 440,
    "maxX" : 480,
    "minY" : 198,
    "maxY" : 231,
    "prop" : {
      "x" : 440,
      "y" : 199,
      "width" : 39,
      "height" : 32
    },
    "textPosition" : {
      "x" : 444,
      "y" : 198
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 474,
          "y" : 204
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 474,
          "y" : 204
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17067,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17077,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17069,
    "reactomeId" : 435347,
    "displayName" : "Fe2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 489,
      "y" : 19
    },
    "minX" : 469,
    "maxX" : 510,
    "minY" : 1,
    "maxY" : 36,
    "prop" : {
      "x" : 469,
      "y" : 2,
      "width" : 40,
      "height" : 34
    },
    "textPosition" : {
      "x" : 473,
      "y" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 504,
          "y" : 7
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 504,
          "y" : 7
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17067,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17077,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17070,
    "reactomeId" : 10759580,
    "displayName" : "SLC40A1:HEPH:6Cu2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 382,
      "y" : 139
    },
    "minX" : 348,
    "maxX" : 454,
    "minY" : 108,
    "maxY" : 165,
    "prop" : {
      "x" : 348,
      "y" : 114,
      "width" : 68,
      "height" : 51
    },
    "textPosition" : {
      "x" : 349,
      "y" : 116
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 416,
          "y" : 114
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 416,
          "y" : 114
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17067,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 419,
          "y" : 138
        },
        "to" : {
          "x" : 446,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 450,
          "y" : 138
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 450,
          "y" : 138
        }
      }
    } ]
  }, {
    "id" : 17072,
    "reactomeId" : 29418,
    "displayName" : "Mn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 179,
      "y" : 674
    },
    "minX" : 158,
    "maxX" : 202,
    "minY" : 654,
    "maxY" : 752,
    "prop" : {
      "x" : 158,
      "y" : 655,
      "width" : 43,
      "height" : 38
    },
    "textPosition" : {
      "x" : 162,
      "y" : 656
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 196,
          "y" : 660
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 196,
          "y" : 660
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17071,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 179,
          "y" : 696
        },
        "to" : {
          "x" : 179,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17073,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 102,
      "y" : 797
    },
    "minX" : 80,
    "maxX" : 179,
    "minY" : 752,
    "maxY" : 813,
    "prop" : {
      "x" : 80,
      "y" : 782,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 81,
      "y" : 787
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 119,
          "y" : 787
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 119,
          "y" : 787
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17071,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 127,
          "y" : 784
        },
        "to" : {
          "x" : 179,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17074,
    "reactomeId" : 266099,
    "displayName" : "Mn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 180,
      "y" : 814
    },
    "minX" : 158,
    "maxX" : 204,
    "minY" : 754,
    "maxY" : 834,
    "prop" : {
      "x" : 158,
      "y" : 794,
      "width" : 45,
      "height" : 40
    },
    "textPosition" : {
      "x" : 158,
      "y" : 803
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 198,
          "y" : 799
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 198,
          "y" : 799
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17071,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 179,
          "y" : 791
        },
        "to" : {
          "x" : 179,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 175,
          "y" : 784
        },
        "b" : {
          "x" : 179,
          "y" : 791
        },
        "c" : {
          "x" : 183,
          "y" : 784
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 183,
          "y" : 784
        }
      }
    } ]
  }, {
    "id" : 17075,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 105,
      "y" : 701
    },
    "minX" : 83,
    "maxX" : 179,
    "minY" : 685,
    "maxY" : 754,
    "prop" : {
      "x" : 83,
      "y" : 686,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 84,
      "y" : 691
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 122,
          "y" : 691
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 122,
          "y" : 691
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17071,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 130,
          "y" : 716
        },
        "to" : {
          "x" : 179,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 138,
          "y" : 717
        },
        "b" : {
          "x" : 130,
          "y" : 716
        },
        "c" : {
          "x" : 133,
          "y" : 723
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 133,
          "y" : 723
        }
      }
    } ]
  }, {
    "id" : 17076,
    "reactomeId" : 10812932,
    "displayName" : "SLC30A10",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 103,
      "y" : 753
    },
    "minX" : 66,
    "maxX" : 171,
    "minY" : 732,
    "maxY" : 769,
    "prop" : {
      "x" : 66,
      "y" : 738,
      "width" : 74,
      "height" : 31
    },
    "textPosition" : {
      "x" : 68,
      "y" : 743
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 140,
          "y" : 738
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 140,
          "y" : 738
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17071,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 143,
          "y" : 753
        },
        "to" : {
          "x" : 163,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 167,
          "y" : 753
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 167,
          "y" : 753
        }
      }
    } ]
  }, {
    "id" : 17078,
    "reactomeId" : 10763224,
    "displayName" : "SLC40A1:CP:6Cu2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 612,
      "y" : 140
    },
    "minX" : 536,
    "maxX" : 654,
    "minY" : 115,
    "maxY" : 160,
    "prop" : {
      "x" : 576,
      "y" : 121,
      "width" : 72,
      "height" : 39
    },
    "textPosition" : {
      "x" : 577,
      "y" : 125
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 648,
          "y" : 121
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 648,
          "y" : 121
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17077,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 573,
          "y" : 140
        },
        "to" : {
          "x" : 544,
          "y" : 140
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 540,
          "y" : 140
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 540,
          "y" : 140
        }
      }
    } ]
  }, {
    "id" : 17080,
    "reactomeId" : 445829,
    "displayName" : "Divalent metals transported by NRAMP1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 101,
      "y" : 244
    },
    "minX" : 49,
    "maxX" : 178,
    "minY" : 216,
    "maxY" : 305,
    "prop" : {
      "x" : 49,
      "y" : 216,
      "width" : 105,
      "height" : 56
    },
    "textPosition" : {
      "x" : 48,
      "y" : 219
    },
    "connectors" : [ {
      "edgeId" : 17079,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 136,
          "y" : 278
        },
        "to" : {
          "x" : 178,
          "y" : 305
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17081,
    "reactomeId" : 1470067,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 253,
      "y" : 360
    },
    "minX" : 178,
    "maxX" : 269,
    "minY" : 305,
    "maxY" : 374,
    "prop" : {
      "x" : 238,
      "y" : 346,
      "width" : 30,
      "height" : 28
    },
    "textPosition" : {
      "x" : 239,
      "y" : 349
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 263,
          "y" : 351
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 263,
          "y" : 351
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17079,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 235,
          "y" : 349
        },
        "to" : {
          "x" : 178,
          "y" : 305
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17082,
    "reactomeId" : 445832,
    "displayName" : "Divalent metals transported by NRAMP1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 149,
      "y" : 382
    },
    "minX" : 97,
    "maxX" : 201,
    "minY" : 306,
    "maxY" : 411,
    "prop" : {
      "x" : 97,
      "y" : 354,
      "width" : 104,
      "height" : 57
    },
    "textPosition" : {
      "x" : 95,
      "y" : 358
    },
    "connectors" : [ {
      "edgeId" : 17079,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 159,
          "y" : 348
        },
        "to" : {
          "x" : 178,
          "y" : 306
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 158,
          "y" : 340
        },
        "b" : {
          "x" : 159,
          "y" : 348
        },
        "c" : {
          "x" : 166,
          "y" : 343
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 166,
          "y" : 343
        }
      }
    } ]
  }, {
    "id" : 17083,
    "reactomeId" : 10759419,
    "displayName" : "SLC11A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 253,
      "y" : 305
    },
    "minX" : 185,
    "maxX" : 292,
    "minY" : 285,
    "maxY" : 320,
    "prop" : {
      "x" : 221,
      "y" : 291,
      "width" : 65,
      "height" : 29
    },
    "textPosition" : {
      "x" : 222,
      "y" : 295
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 286,
          "y" : 291
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 286,
          "y" : 291
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17079,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 218,
          "y" : 305
        },
        "to" : {
          "x" : 193,
          "y" : 305
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 189,
          "y" : 305
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 189,
          "y" : 305
        }
      }
    } ]
  }, {
    "id" : 17085,
    "reactomeId" : 29426,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1189,
      "y" : 247
    },
    "minX" : 845,
    "maxX" : 1681,
    "minY" : 136,
    "maxY" : 375,
    "prop" : {
      "x" : 1167,
      "y" : 232,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1168,
      "y" : 237
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1207,
          "y" : 237
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1207,
          "y" : 237
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17088,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1182,
          "y" : 266
        },
        "to" : {
          "x" : 1141,
          "y" : 360
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17092,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1205,
          "y" : 266
        },
        "to" : {
          "x" : 1324,
          "y" : 375
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17096,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17098,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17101,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17103,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1164,
          "y" : 239
        },
        "to" : {
          "x" : 845,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1156,
          "y" : 241
        },
        "b" : {
          "x" : 1164,
          "y" : 239
        },
        "c" : {
          "x" : 1159,
          "y" : 233
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1159,
          "y" : 233
        }
      }
    }, {
      "edgeId" : 17148,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1215,
          "y" : 243
        },
        "to" : {
          "x" : 1626,
          "y" : 177
        }
      }, {
        "from" : {
          "x" : 1626,
          "y" : 177
        },
        "to" : {
          "x" : 1681,
          "y" : 140
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17084,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17086,
    "reactomeId" : 216785,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1099,
      "y" : 413
    },
    "minX" : 1077,
    "maxX" : 1144,
    "minY" : 361,
    "maxY" : 429,
    "prop" : {
      "x" : 1077,
      "y" : 398,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1078,
      "y" : 403
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1117,
          "y" : 403
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1117,
          "y" : 403
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17088,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1112,
          "y" : 395
        },
        "to" : {
          "x" : 1144,
          "y" : 361
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1114,
          "y" : 387
        },
        "b" : {
          "x" : 1112,
          "y" : 395
        },
        "c" : {
          "x" : 1120,
          "y" : 393
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1120,
          "y" : 393
        }
      }
    }, {
      "edgeId" : 17084,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17087,
    "reactomeId" : 10759443,
    "displayName" : "SLC30A5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1017,
      "y" : 367
    },
    "minX" : 982,
    "maxX" : 1089,
    "minY" : 348,
    "maxY" : 381,
    "prop" : {
      "x" : 982,
      "y" : 354,
      "width" : 71,
      "height" : 27
    },
    "textPosition" : {
      "x" : 986,
      "y" : 357
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1053,
          "y" : 354
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1053,
          "y" : 354
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17084,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1056,
          "y" : 366
        },
        "to" : {
          "x" : 1081,
          "y" : 365
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1085,
          "y" : 365
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1085,
          "y" : 365
        }
      }
    } ]
  }, {
    "id" : 17089,
    "reactomeId" : 5339575,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1157,
      "y" : 424
    },
    "minX" : 1141,
    "maxX" : 1174,
    "minY" : 360,
    "maxY" : 440,
    "prop" : {
      "x" : 1141,
      "y" : 409,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1143,
      "y" : 414
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1168,
          "y" : 414
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1168,
          "y" : 414
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17088,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1153,
          "y" : 406
        },
        "to" : {
          "x" : 1141,
          "y" : 360
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1141,
            "y" : 377
          },
          "b" : {
            "x" : 1153,
            "y" : 389
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1147,
            "y" : 383
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17090,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1216,
      "y" : 323
    },
    "minX" : 1144,
    "maxX" : 1325,
    "minY" : 309,
    "maxY" : 375,
    "prop" : {
      "x" : 1201,
      "y" : 310,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1202,
      "y" : 312
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1226,
          "y" : 315
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1226,
          "y" : 315
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17088,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1198,
          "y" : 330
        },
        "to" : {
          "x" : 1144,
          "y" : 361
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1165,
            "y" : 339
          },
          "b" : {
            "x" : 1177,
            "y" : 351
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1171,
            "y" : 345
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1194,
          "y" : 337
        },
        "b" : {
          "x" : 1198,
          "y" : 330
        },
        "c" : {
          "x" : 1190,
          "y" : 330
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1190,
          "y" : 330
        }
      }
    }, {
      "edgeId" : 17092,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1234,
          "y" : 330
        },
        "to" : {
          "x" : 1325,
          "y" : 375
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1273,
            "y" : 346
          },
          "b" : {
            "x" : 1285,
            "y" : 358
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1279,
            "y" : 352
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1242,
          "y" : 329
        },
        "b" : {
          "x" : 1234,
          "y" : 330
        },
        "c" : {
          "x" : 1238,
          "y" : 337
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1238,
          "y" : 337
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17091,
    "reactomeId" : 10759450,
    "displayName" : "SLC30A8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1212,
      "y" : 398
    },
    "minX" : 1150,
    "maxX" : 1249,
    "minY" : 361,
    "maxY" : 410,
    "prop" : {
      "x" : 1182,
      "y" : 387,
      "width" : 61,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1185,
      "y" : 381
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1243,
          "y" : 387
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1243,
          "y" : 387
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17088,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1191,
          "y" : 384
        },
        "to" : {
          "x" : 1157,
          "y" : 366
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1154,
          "y" : 365
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1154,
          "y" : 365
        }
      }
    } ]
  }, {
    "id" : 17093,
    "reactomeId" : 425969,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1497,
      "y" : 481
    },
    "minX" : 1324,
    "maxX" : 1567,
    "minY" : 375,
    "maxY" : 578,
    "prop" : {
      "x" : 1482,
      "y" : 466,
      "width" : 31,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1484,
      "y" : 471
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1508,
          "y" : 471
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1508,
          "y" : 471
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17092,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1479,
          "y" : 478
        },
        "to" : {
          "x" : 1334,
          "y" : 457
        }
      }, {
        "from" : {
          "x" : 1334,
          "y" : 457
        },
        "to" : {
          "x" : 1324,
          "y" : 375
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1400,
            "y" : 461
          },
          "b" : {
            "x" : 1412,
            "y" : 473
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1406,
            "y" : 467
          }
        }
      }
    }, {
      "edgeId" : 17140,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1508,
          "y" : 500
        },
        "to" : {
          "x" : 1567,
          "y" : 578
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17094,
    "reactomeId" : 216667,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1368,
      "y" : 425
    },
    "minX" : 1325,
    "maxX" : 1392,
    "minY" : 375,
    "maxY" : 441,
    "prop" : {
      "x" : 1346,
      "y" : 410,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1347,
      "y" : 415
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1386,
          "y" : 415
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1386,
          "y" : 415
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17092,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1354,
          "y" : 407
        },
        "to" : {
          "x" : 1325,
          "y" : 375
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1346,
          "y" : 405
        },
        "b" : {
          "x" : 1354,
          "y" : 407
        },
        "c" : {
          "x" : 1352,
          "y" : 399
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1352,
          "y" : 399
        }
      }
    }, {
      "edgeId" : 17096,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17095,
    "reactomeId" : 10759457,
    "displayName" : "SLC30A8 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1284,
      "y" : 414
    },
    "minX" : 1253,
    "maxX" : 1322,
    "minY" : 378,
    "maxY" : 433,
    "prop" : {
      "x" : 1253,
      "y" : 396,
      "width" : 63,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1252,
      "y" : 398
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1316,
          "y" : 396
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1316,
          "y" : 396
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17092,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1302,
          "y" : 393
        },
        "to" : {
          "x" : 1311,
          "y" : 385
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1314,
          "y" : 382
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1314,
          "y" : 382
        }
      }
    } ]
  }, {
    "id" : 17097,
    "reactomeId" : 10820414,
    "displayName" : "SLC30A5 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1453,
      "y" : 373
    },
    "minX" : 1373,
    "maxX" : 1494,
    "minY" : 350,
    "maxY" : 391,
    "prop" : {
      "x" : 1419,
      "y" : 356,
      "width" : 69,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1420,
      "y" : 356
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1488,
          "y" : 356
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1488,
          "y" : 356
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17096,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1416,
          "y" : 373
        },
        "to" : {
          "x" : 1381,
          "y" : 373
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1377,
          "y" : 373
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1377,
          "y" : 373
        }
      }
    } ]
  }, {
    "id" : 17099,
    "reactomeId" : 158417,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1178,
      "y" : 20
    },
    "minX" : 843,
    "maxX" : 1680,
    "minY" : 4,
    "maxY" : 139,
    "prop" : {
      "x" : 1156,
      "y" : 5,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1157,
      "y" : 10
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1196,
          "y" : 10
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1196,
          "y" : 10
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17098,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17101,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17103,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1153,
          "y" : 27
        },
        "to" : {
          "x" : 843,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17148,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1204,
          "y" : 23
        },
        "to" : {
          "x" : 1622,
          "y" : 91
        }
      }, {
        "from" : {
          "x" : 1622,
          "y" : 91
        },
        "to" : {
          "x" : 1680,
          "y" : 139
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1211,
          "y" : 20
        },
        "b" : {
          "x" : 1204,
          "y" : 23
        },
        "c" : {
          "x" : 1210,
          "y" : 28
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1210,
          "y" : 28
        }
      }
    } ]
  }, {
    "id" : 17100,
    "reactomeId" : 10759594,
    "displayName" : "SLC39A3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1161,
      "y" : 140
    },
    "minX" : 1086,
    "maxX" : 1203,
    "minY" : 123,
    "maxY" : 152,
    "prop" : {
      "x" : 1125,
      "y" : 129,
      "width" : 72,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1130,
      "y" : 130
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1197,
          "y" : 129
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1197,
          "y" : 129
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17098,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1119,
          "y" : 139
        },
        "to" : {
          "x" : 1094,
          "y" : 139
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1090,
          "y" : 139
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1090,
          "y" : 139
        }
      }
    } ]
  }, {
    "id" : 17102,
    "reactomeId" : 10759567,
    "displayName" : "SLC39A6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1601,
      "y" : 140
    },
    "minX" : 1535,
    "maxX" : 1644,
    "minY" : 123,
    "maxY" : 152,
    "prop" : {
      "x" : 1564,
      "y" : 129,
      "width" : 74,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1570,
      "y" : 130
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1638,
          "y" : 129
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1638,
          "y" : 129
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17101,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1558,
          "y" : 141
        },
        "to" : {
          "x" : 1543,
          "y" : 141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1539,
          "y" : 142
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1539,
          "y" : 142
        }
      }
    } ]
  }, {
    "id" : 17104,
    "reactomeId" : 425425,
    "displayName" : "HCO3-",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 845,
      "y" : 57
    },
    "minX" : 820,
    "maxX" : 872,
    "minY" : 41,
    "maxY" : 136,
    "prop" : {
      "x" : 820,
      "y" : 42,
      "width" : 51,
      "height" : 31
    },
    "textPosition" : {
      "x" : 822,
      "y" : 47
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 866,
          "y" : 47
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 866,
          "y" : 47
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17103,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 844,
          "y" : 76
        },
        "to" : {
          "x" : 843,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 837,
            "y" : 100
          },
          "b" : {
            "x" : 849,
            "y" : 112
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 843,
            "y" : 106
          }
        }
      }
    } ]
  }, {
    "id" : 17105,
    "reactomeId" : 111627,
    "displayName" : "HCO3-",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 847,
      "y" : 221
    },
    "minX" : 822,
    "maxX" : 874,
    "minY" : 136,
    "maxY" : 237,
    "prop" : {
      "x" : 822,
      "y" : 206,
      "width" : 51,
      "height" : 31
    },
    "textPosition" : {
      "x" : 824,
      "y" : 211
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 868,
          "y" : 211
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 868,
          "y" : 211
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17103,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 846,
          "y" : 203
        },
        "to" : {
          "x" : 845,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 839,
            "y" : 163
          },
          "b" : {
            "x" : 851,
            "y" : 175
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 845,
            "y" : 169
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 842,
          "y" : 196
        },
        "b" : {
          "x" : 846,
          "y" : 203
        },
        "c" : {
          "x" : 850,
          "y" : 196
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 850,
          "y" : 196
        }
      }
    } ]
  }, {
    "id" : 17106,
    "reactomeId" : 10759587,
    "displayName" : "SLC39A8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 742,
      "y" : 135
    },
    "minX" : 699,
    "maxX" : 836,
    "minY" : 109,
    "maxY" : 155,
    "prop" : {
      "x" : 699,
      "y" : 115,
      "width" : 86,
      "height" : 40
    },
    "textPosition" : {
      "x" : 711,
      "y" : 124
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 785,
          "y" : 115
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 785,
          "y" : 115
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17103,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 791,
          "y" : 135
        },
        "to" : {
          "x" : 828,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 832,
          "y" : 135
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 832,
          "y" : 135
        }
      }
    } ]
  }, {
    "id" : 17108,
    "reactomeId" : 74113,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 956,
      "y" : 820
    },
    "minX" : 845,
    "maxX" : 1040,
    "minY" : 754,
    "maxY" : 836,
    "prop" : {
      "x" : 937,
      "y" : 805,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 938,
      "y" : 810
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 970,
          "y" : 810
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 970,
          "y" : 810
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17131,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 934,
          "y" : 808
        },
        "to" : {
          "x" : 845,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17107,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 978,
          "y" : 805
        },
        "to" : {
          "x" : 1040,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1003,
            "y" : 773
          },
          "b" : {
            "x" : 1015,
            "y" : 785
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1009,
            "y" : 779
          }
        }
      }
    } ]
  }, {
    "id" : 17109,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1105,
      "y" : 675
    },
    "minX" : 1040,
    "maxX" : 1185,
    "minY" : 659,
    "maxY" : 755,
    "prop" : {
      "x" : 1083,
      "y" : 660,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1084,
      "y" : 665
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1122,
          "y" : 665
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1122,
          "y" : 665
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17107,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1092,
          "y" : 694
        },
        "to" : {
          "x" : 1040,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17114,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1120,
          "y" : 694
        },
        "to" : {
          "x" : 1185,
          "y" : 755
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17110,
    "reactomeId" : 83910,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 949,
      "y" : 674
    },
    "minX" : 507,
    "maxX" : 1041,
    "minY" : 444,
    "maxY" : 754,
    "prop" : {
      "x" : 930,
      "y" : 659,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 931,
      "y" : 664
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 963,
          "y" : 664
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 963,
          "y" : 664
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17131,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 927,
          "y" : 688
        },
        "to" : {
          "x" : 843,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 924,
          "y" : 695
        },
        "b" : {
          "x" : 927,
          "y" : 688
        },
        "c" : {
          "x" : 919,
          "y" : 689
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 919,
          "y" : 689
        }
      }
    }, {
      "edgeId" : 17135,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 927,
          "y" : 664
        },
        "to" : {
          "x" : 507,
          "y" : 444
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 17107,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 966,
          "y" : 693
        },
        "to" : {
          "x" : 1041,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 997,
            "y" : 717
          },
          "b" : {
            "x" : 1009,
            "y" : 729
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1003,
            "y" : 723
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 974,
          "y" : 694
        },
        "b" : {
          "x" : 966,
          "y" : 693
        },
        "c" : {
          "x" : 969,
          "y" : 700
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 969,
          "y" : 700
        }
      }
    }, {
      "edgeId" : 17144,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 927,
          "y" : 668
        },
        "to" : {
          "x" : 516,
          "y" : 554
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17111,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1113,
      "y" : 823
    },
    "minX" : 1041,
    "maxX" : 1187,
    "minY" : 752,
    "maxY" : 839,
    "prop" : {
      "x" : 1091,
      "y" : 808,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1092,
      "y" : 813
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1130,
          "y" : 813
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1130,
          "y" : 813
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17107,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1096,
          "y" : 805
        },
        "to" : {
          "x" : 1041,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1088,
          "y" : 803
        },
        "b" : {
          "x" : 1096,
          "y" : 805
        },
        "c" : {
          "x" : 1094,
          "y" : 797
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1094,
          "y" : 797
        }
      }
    }, {
      "edgeId" : 17114,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1129,
          "y" : 805
        },
        "to" : {
          "x" : 1187,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1131,
          "y" : 797
        },
        "b" : {
          "x" : 1129,
          "y" : 805
        },
        "c" : {
          "x" : 1137,
          "y" : 803
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1137,
          "y" : 803
        }
      }
    } ]
  }, {
    "id" : 17112,
    "reactomeId" : 10757907,
    "displayName" : "SLC8A1,2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 939,
      "y" : 755
    },
    "minX" : 899,
    "maxX" : 1031,
    "minY" : 742,
    "maxY" : 769,
    "prop" : {
      "x" : 899,
      "y" : 742,
      "width" : 80,
      "height" : 27
    },
    "textPosition" : {
      "x" : 900,
      "y" : 745
    },
    "connectors" : [ {
      "edgeId" : 17107,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 985,
          "y" : 754
        },
        "to" : {
          "x" : 1023,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1027,
          "y" : 754
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1027,
          "y" : 754
        }
      }
    } ]
  }, {
    "id" : 17113,
    "reactomeId" : 10757912,
    "displayName" : "SRI",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1049,
      "y" : 621
    },
    "minX" : 1036,
    "maxX" : 1068,
    "minY" : 604,
    "maxY" : 745,
    "prop" : {
      "x" : 1036,
      "y" : 610,
      "width" : 26,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1037,
      "y" : 604
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1062,
          "y" : 610
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1062,
          "y" : 610
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17107,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1048,
          "y" : 636
        },
        "to" : {
          "x" : 1040,
          "y" : 745
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1037,
          "y" : 738
        },
        "b" : {
          "x" : 1040,
          "y" : 745
        },
        "c" : {
          "x" : 1044,
          "y" : 738
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1044,
          "y" : 738
        }
      }
    } ]
  }, {
    "id" : 17115,
    "reactomeId" : 29804,
    "displayName" : "K+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1258,
      "y" : 676
    },
    "minX" : 1185,
    "maxX" : 1324,
    "minY" : 579,
    "maxY" : 755,
    "prop" : {
      "x" : 1242,
      "y" : 661,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1245,
      "y" : 666
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1269,
          "y" : 666
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1269,
          "y" : 666
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17120,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1268,
          "y" : 658
        },
        "to" : {
          "x" : 1324,
          "y" : 579
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1269,
          "y" : 650
        },
        "b" : {
          "x" : 1268,
          "y" : 658
        },
        "c" : {
          "x" : 1275,
          "y" : 655
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1275,
          "y" : 655
        }
      }
    }, {
      "edgeId" : 17114,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1243,
          "y" : 695
        },
        "to" : {
          "x" : 1185,
          "y" : 755
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17116,
    "reactomeId" : 74113,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1187,
      "y" : 820
    },
    "minX" : 1168,
    "maxX" : 1207,
    "minY" : 755,
    "maxY" : 836,
    "prop" : {
      "x" : 1168,
      "y" : 805,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1169,
      "y" : 810
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1201,
          "y" : 810
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1201,
          "y" : 810
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17114,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1186,
          "y" : 802
        },
        "to" : {
          "x" : 1185,
          "y" : 755
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1179,
            "y" : 772
          },
          "b" : {
            "x" : 1191,
            "y" : 784
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1185,
            "y" : 778
          }
        }
      }
    } ]
  }, {
    "id" : 17117,
    "reactomeId" : 74126,
    "displayName" : "K+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1264,
      "y" : 824
    },
    "minX" : 1187,
    "maxX" : 1281,
    "minY" : 752,
    "maxY" : 840,
    "prop" : {
      "x" : 1248,
      "y" : 809,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1251,
      "y" : 814
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1275,
          "y" : 814
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1275,
          "y" : 814
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17114,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1245,
          "y" : 809
        },
        "to" : {
          "x" : 1187,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1237,
          "y" : 807
        },
        "b" : {
          "x" : 1245,
          "y" : 809
        },
        "c" : {
          "x" : 1243,
          "y" : 801
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1243,
          "y" : 801
        }
      }
    } ]
  }, {
    "id" : 17118,
    "reactomeId" : 83910,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1184,
      "y" : 676
    },
    "minX" : 1165,
    "maxX" : 1324,
    "minY" : 582,
    "maxY" : 752,
    "prop" : {
      "x" : 1165,
      "y" : 661,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1166,
      "y" : 666
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1198,
          "y" : 666
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1198,
          "y" : 666
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17120,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1206,
          "y" : 663
        },
        "to" : {
          "x" : 1324,
          "y" : 582
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1259,
            "y" : 616
          },
          "b" : {
            "x" : 1271,
            "y" : 628
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1265,
            "y" : 622
          }
        }
      }
    }, {
      "edgeId" : 17114,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1184,
          "y" : 695
        },
        "to" : {
          "x" : 1187,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1179,
            "y" : 717
          },
          "b" : {
            "x" : 1191,
            "y" : 729
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1185,
            "y" : 723
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1188,
          "y" : 702
        },
        "b" : {
          "x" : 1184,
          "y" : 695
        },
        "c" : {
          "x" : 1180,
          "y" : 702
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1180,
          "y" : 702
        }
      }
    } ]
  }, {
    "id" : 17119,
    "reactomeId" : 10757933,
    "displayName" : "SLC24A1-4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1296,
      "y" : 756
    },
    "minX" : 1193,
    "maxX" : 1335,
    "minY" : 743,
    "maxY" : 770,
    "prop" : {
      "x" : 1257,
      "y" : 743,
      "width" : 78,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1259,
      "y" : 746
    },
    "connectors" : [ {
      "edgeId" : 17114,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1251,
          "y" : 754
        },
        "to" : {
          "x" : 1201,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1197,
          "y" : 752
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1197,
          "y" : 752
        }
      }
    } ]
  }, {
    "id" : 17121,
    "reactomeId" : 5626313,
    "displayName" : "K+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1295,
      "y" : 503
    },
    "minX" : 1279,
    "maxX" : 1324,
    "minY" : 487,
    "maxY" : 582,
    "prop" : {
      "x" : 1279,
      "y" : 488,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1282,
      "y" : 493
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1306,
          "y" : 493
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1306,
          "y" : 493
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17120,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1300,
          "y" : 522
        },
        "to" : {
          "x" : 1324,
          "y" : 582
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17122,
    "reactomeId" : 167012,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1350,
      "y" : 500
    },
    "minX" : 1324,
    "maxX" : 1374,
    "minY" : 484,
    "maxY" : 582,
    "prop" : {
      "x" : 1328,
      "y" : 485,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1329,
      "y" : 490
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1368,
          "y" : 490
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1368,
          "y" : 490
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17120,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1345,
          "y" : 519
        },
        "to" : {
          "x" : 1324,
          "y" : 582
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17123,
    "reactomeId" : 425958,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1413,
      "y" : 502
    },
    "minX" : 1324,
    "maxX" : 1568,
    "minY" : 486,
    "maxY" : 579,
    "prop" : {
      "x" : 1394,
      "y" : 487,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1396,
      "y" : 492
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1428,
          "y" : 492
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1428,
          "y" : 492
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17120,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1395,
          "y" : 521
        },
        "to" : {
          "x" : 1324,
          "y" : 579
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1353,
            "y" : 544
          },
          "b" : {
            "x" : 1365,
            "y" : 556
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1359,
            "y" : 550
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1392,
          "y" : 528
        },
        "b" : {
          "x" : 1395,
          "y" : 521
        },
        "c" : {
          "x" : 1387,
          "y" : 522
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1387,
          "y" : 522
        }
      }
    }, {
      "edgeId" : 17140,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1436,
          "y" : 511
        },
        "to" : {
          "x" : 1568,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1444,
          "y" : 511
        },
        "b" : {
          "x" : 1436,
          "y" : 511
        },
        "c" : {
          "x" : 1440,
          "y" : 518
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1440,
          "y" : 518
        }
      }
    } ]
  }, {
    "id" : 17124,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1389,
      "y" : 673
    },
    "minX" : 1324,
    "maxX" : 1462,
    "minY" : 579,
    "maxY" : 753,
    "prop" : {
      "x" : 1367,
      "y" : 658,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1368,
      "y" : 663
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1406,
          "y" : 663
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1406,
          "y" : 663
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17120,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1378,
          "y" : 655
        },
        "to" : {
          "x" : 1324,
          "y" : 579
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1371,
          "y" : 652
        },
        "b" : {
          "x" : 1378,
          "y" : 655
        },
        "c" : {
          "x" : 1377,
          "y" : 647
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1377,
          "y" : 647
        }
      }
    }, {
      "edgeId" : 17126,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1403,
          "y" : 692
        },
        "to" : {
          "x" : 1462,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17125,
    "reactomeId" : 10791439,
    "displayName" : "SLC24A5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1408,
      "y" : 580
    },
    "minX" : 1332,
    "maxX" : 1447,
    "minY" : 562,
    "maxY" : 593,
    "prop" : {
      "x" : 1376,
      "y" : 568,
      "width" : 65,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1377,
      "y" : 570
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1441,
          "y" : 568
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1441,
          "y" : 568
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17120,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1373,
          "y" : 580
        },
        "to" : {
          "x" : 1340,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1336,
          "y" : 581
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1336,
          "y" : 581
        }
      }
    } ]
  }, {
    "id" : 17127,
    "reactomeId" : 425815,
    "displayName" : "Li+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1390,
      "y" : 823
    },
    "minX" : 1374,
    "maxX" : 1462,
    "minY" : 753,
    "maxY" : 839,
    "prop" : {
      "x" : 1374,
      "y" : 808,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1376,
      "y" : 813
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1401,
          "y" : 813
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1401,
          "y" : 813
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17126,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1405,
          "y" : 805
        },
        "to" : {
          "x" : 1462,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1427,
            "y" : 773
          },
          "b" : {
            "x" : 1439,
            "y" : 785
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1433,
            "y" : 779
          }
        }
      }
    } ]
  }, {
    "id" : 17128,
    "reactomeId" : 425810,
    "displayName" : "Li+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1487,
      "y" : 678
    },
    "minX" : 1463,
    "maxX" : 1504,
    "minY" : 662,
    "maxY" : 753,
    "prop" : {
      "x" : 1471,
      "y" : 663,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1473,
      "y" : 668
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1498,
          "y" : 668
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1498,
          "y" : 668
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17126,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1482,
          "y" : 697
        },
        "to" : {
          "x" : 1463,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1466,
            "y" : 719
          },
          "b" : {
            "x" : 1478,
            "y" : 731
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1472,
            "y" : 725
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1484,
          "y" : 705
        },
        "b" : {
          "x" : 1482,
          "y" : 697
        },
        "c" : {
          "x" : 1476,
          "y" : 702
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1476,
          "y" : 702
        }
      }
    } ]
  }, {
    "id" : 17129,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1477,
      "y" : 823
    },
    "minX" : 1455,
    "maxX" : 1500,
    "minY" : 753,
    "maxY" : 839,
    "prop" : {
      "x" : 1455,
      "y" : 808,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1456,
      "y" : 813
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1494,
          "y" : 813
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1494,
          "y" : 813
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17126,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1473,
          "y" : 805
        },
        "to" : {
          "x" : 1463,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1468,
          "y" : 799
        },
        "b" : {
          "x" : 1473,
          "y" : 805
        },
        "c" : {
          "x" : 1476,
          "y" : 797
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1476,
          "y" : 797
        }
      }
    } ]
  }, {
    "id" : 17130,
    "reactomeId" : 10757940,
    "displayName" : "SLC24A6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1387,
      "y" : 754
    },
    "minX" : 1354,
    "maxX" : 1453,
    "minY" : 736,
    "maxY" : 767,
    "prop" : {
      "x" : 1354,
      "y" : 742,
      "width" : 67,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1356,
      "y" : 744
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1421,
          "y" : 742
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1421,
          "y" : 742
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17126,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1424,
          "y" : 754
        },
        "to" : {
          "x" : 1445,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1449,
          "y" : 754
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1449,
          "y" : 754
        }
      }
    } ]
  }, {
    "id" : 17132,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 834,
      "y" : 691
    },
    "minX" : 819,
    "maxX" : 850,
    "minY" : 677,
    "maxY" : 754,
    "prop" : {
      "x" : 819,
      "y" : 678,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 820,
      "y" : 680
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 844,
          "y" : 683
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 844,
          "y" : 683
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17131,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 836,
          "y" : 707
        },
        "to" : {
          "x" : 845,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17133,
    "reactomeId" : 351626,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 841,
      "y" : 819
    },
    "minX" : 827,
    "maxX" : 856,
    "minY" : 754,
    "maxY" : 834,
    "prop" : {
      "x" : 827,
      "y" : 805,
      "width" : 28,
      "height" : 29
    },
    "textPosition" : {
      "x" : 827,
      "y" : 809
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 850,
          "y" : 810
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 850,
          "y" : 810
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17131,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 841,
          "y" : 802
        },
        "to" : {
          "x" : 843,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 837,
          "y" : 795
        },
        "b" : {
          "x" : 841,
          "y" : 802
        },
        "c" : {
          "x" : 845,
          "y" : 795
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 845,
          "y" : 795
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17134,
    "reactomeId" : 10757995,
    "displayName" : "SLC9A1-5",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 736,
      "y" : 753
    },
    "minX" : 699,
    "maxX" : 838,
    "minY" : 743,
    "maxY" : 764,
    "prop" : {
      "x" : 699,
      "y" : 743,
      "width" : 75,
      "height" : 21
    },
    "textPosition" : {
      "x" : 703,
      "y" : 743
    },
    "connectors" : [ {
      "edgeId" : 17131,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 780,
          "y" : 753
        },
        "to" : {
          "x" : 830,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 834,
          "y" : 754
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 834,
          "y" : 754
        }
      }
    } ]
  }, {
    "id" : 17136,
    "reactomeId" : 425978,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 399,
      "y" : 388
    },
    "minX" : 383,
    "maxX" : 507,
    "minY" : 372,
    "maxY" : 444,
    "prop" : {
      "x" : 383,
      "y" : 373,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 385,
      "y" : 378
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 410,
          "y" : 378
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 410,
          "y" : 378
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17135,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 418,
          "y" : 396
        },
        "to" : {
          "x" : 507,
          "y" : 444
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17137,
    "reactomeId" : 425971,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 466,
      "y" : 367
    },
    "minX" : 447,
    "maxX" : 507,
    "minY" : 351,
    "maxY" : 445,
    "prop" : {
      "x" : 447,
      "y" : 352,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 449,
      "y" : 357
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 481,
          "y" : 357
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 481,
          "y" : 357
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17135,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 474,
          "y" : 386
        },
        "to" : {
          "x" : 507,
          "y" : 445
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 481,
          "y" : 390
        },
        "b" : {
          "x" : 474,
          "y" : 386
        },
        "c" : {
          "x" : 474,
          "y" : 394
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 474,
          "y" : 394
        }
      }
    } ]
  }, {
    "id" : 17138,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 583,
      "y" : 514
    },
    "minX" : 507,
    "maxX" : 599,
    "minY" : 445,
    "maxY" : 554,
    "prop" : {
      "x" : 568,
      "y" : 501,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 569,
      "y" : 503
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 593,
          "y" : 506
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 593,
          "y" : 506
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17135,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 568,
          "y" : 498
        },
        "to" : {
          "x" : 507,
          "y" : 445
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 560,
          "y" : 496
        },
        "b" : {
          "x" : 568,
          "y" : 498
        },
        "c" : {
          "x" : 565,
          "y" : 490
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 565,
          "y" : 490
        }
      }
    }, {
      "edgeId" : 17144,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 565,
          "y" : 523
        },
        "to" : {
          "x" : 518,
          "y" : 554
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 561,
          "y" : 530
        },
        "b" : {
          "x" : 565,
          "y" : 523
        },
        "c" : {
          "x" : 557,
          "y" : 523
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 557,
          "y" : 523
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17139,
    "reactomeId" : 10757970,
    "displayName" : "SLC9A6,7",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 413,
      "y" : 444
    },
    "minX" : 382,
    "maxX" : 498,
    "minY" : 433,
    "maxY" : 456,
    "prop" : {
      "x" : 382,
      "y" : 433,
      "width" : 63,
      "height" : 23
    },
    "textPosition" : {
      "x" : 384,
      "y" : 427
    },
    "connectors" : [ {
      "edgeId" : 17135,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 451,
          "y" : 443
        },
        "to" : {
          "x" : 490,
          "y" : 443
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 494,
          "y" : 443
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 494,
          "y" : 443
        }
      }
    } ]
  }, {
    "id" : 17141,
    "reactomeId" : 83910,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1554,
      "y" : 662
    },
    "minX" : 1535,
    "maxX" : 1574,
    "minY" : 578,
    "maxY" : 678,
    "prop" : {
      "x" : 1535,
      "y" : 647,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1536,
      "y" : 652
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1568,
          "y" : 652
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1568,
          "y" : 652
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17140,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1556,
          "y" : 644
        },
        "to" : {
          "x" : 1567,
          "y" : 578
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 17142,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1630,
      "y" : 628
    },
    "minX" : 1568,
    "maxX" : 1646,
    "minY" : 577,
    "maxY" : 641,
    "prop" : {
      "x" : 1615,
      "y" : 615,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1616,
      "y" : 617
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1640,
          "y" : 620
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1640,
          "y" : 620
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17140,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1612,
          "y" : 615
        },
        "to" : {
          "x" : 1568,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1604,
          "y" : 613
        },
        "b" : {
          "x" : 1612,
          "y" : 615
        },
        "c" : {
          "x" : 1609,
          "y" : 607
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1609,
          "y" : 607
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17143,
    "reactomeId" : 10758006,
    "displayName" : "SLC9A7/8",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1641,
      "y" : 548
    },
    "minX" : 1577,
    "maxX" : 1678,
    "minY" : 536,
    "maxY" : 581,
    "prop" : {
      "x" : 1604,
      "y" : 536,
      "width" : 74,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1608,
      "y" : 538
    },
    "connectors" : [ {
      "edgeId" : 17140,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1613,
          "y" : 567
        },
        "to" : {
          "x" : 1585,
          "y" : 575
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1581,
          "y" : 577
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1581,
          "y" : 577
        }
      }
    } ]
  }, {
    "id" : 17145,
    "reactomeId" : 425999,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 390,
      "y" : 576
    },
    "minX" : 374,
    "maxX" : 516,
    "minY" : 554,
    "maxY" : 592,
    "prop" : {
      "x" : 374,
      "y" : 561,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 376,
      "y" : 566
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 401,
          "y" : 566
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 401,
          "y" : 566
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17144,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 409,
          "y" : 573
        },
        "to" : {
          "x" : 516,
          "y" : 554
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17146,
    "reactomeId" : 425977,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 437,
      "y" : 534
    },
    "minX" : 418,
    "maxX" : 518,
    "minY" : 518,
    "maxY" : 554,
    "prop" : {
      "x" : 418,
      "y" : 519,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 420,
      "y" : 524
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 452,
          "y" : 524
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 452,
          "y" : 524
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17144,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 460,
          "y" : 538
        },
        "to" : {
          "x" : 518,
          "y" : 554
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 468,
          "y" : 536
        },
        "b" : {
          "x" : 460,
          "y" : 538
        },
        "c" : {
          "x" : 466,
          "y" : 544
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 466,
          "y" : 544
        }
      }
    } ]
  }, {
    "id" : 17147,
    "reactomeId" : 10757957,
    "displayName" : "SLC9A9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 499,
      "y" : 611
    },
    "minX" : 469,
    "maxX" : 535,
    "minY" : 562,
    "maxY" : 625,
    "prop" : {
      "x" : 469,
      "y" : 598,
      "width" : 60,
      "height" : 27
    },
    "textPosition" : {
      "x" : 472,
      "y" : 601
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 529,
          "y" : 598
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 529,
          "y" : 598
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17144,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 503,
          "y" : 595
        },
        "to" : {
          "x" : 512,
          "y" : 570
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 514,
          "y" : 566
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 514,
          "y" : 566
        }
      }
    } ]
  }, {
    "id" : 17149,
    "reactomeId" : 351626,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1680,
      "y" : 72
    },
    "minX" : 1666,
    "maxX" : 1695,
    "minY" : 57,
    "maxY" : 140,
    "prop" : {
      "x" : 1666,
      "y" : 58,
      "width" : 28,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1666,
      "y" : 62
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1689,
          "y" : 63
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1689,
          "y" : 63
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17148,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1680,
          "y" : 90
        },
        "to" : {
          "x" : 1681,
          "y" : 140
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1674,
            "y" : 109
          },
          "b" : {
            "x" : 1686,
            "y" : 121
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1680,
            "y" : 115
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17150,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1682,
      "y" : 203
    },
    "minX" : 1667,
    "maxX" : 1698,
    "minY" : 139,
    "maxY" : 216,
    "prop" : {
      "x" : 1667,
      "y" : 190,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1668,
      "y" : 192
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1692,
          "y" : 195
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1692,
          "y" : 195
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17148,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1681,
          "y" : 187
        },
        "to" : {
          "x" : 1680,
          "y" : 139
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1674,
            "y" : 157
          },
          "b" : {
            "x" : 1686,
            "y" : 169
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1680,
            "y" : 163
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1677,
          "y" : 180
        },
        "b" : {
          "x" : 1681,
          "y" : 187
        },
        "c" : {
          "x" : 1685,
          "y" : 180
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1685,
          "y" : 180
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 17151,
    "reactomeId" : 10759436,
    "displayName" : "SLC30A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1746,
      "y" : 138
    },
    "minX" : 1688,
    "maxX" : 1782,
    "minY" : 121,
    "maxY" : 150,
    "prop" : {
      "x" : 1717,
      "y" : 127,
      "width" : 59,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1719,
      "y" : 121
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1776,
          "y" : 127
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1776,
          "y" : 127
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 17148,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1714,
          "y" : 138
        },
        "to" : {
          "x" : 1696,
          "y" : 139
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1692,
          "y" : 139
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1692,
          "y" : 139
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 17120,
    "reactomeId" : 10791442,
    "displayName" : "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1324,
      "y" : 581
    },
    "minX" : 1318,
    "maxX" : 1330,
    "minY" : 575,
    "maxY" : 587,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1324,
        "y" : 582
      },
      "to" : {
        "x" : 1324,
        "y" : 581
      }
    }, {
      "from" : {
        "x" : 1324,
        "y" : 581
      },
      "to" : {
        "x" : 1324,
        "y" : 579
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1318,
        "y" : 575
      },
      "b" : {
        "x" : 1330,
        "y" : 587
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1324,
        "y" : 581
      }
    },
    "inputs" : [ {
      "id" : 17121,
      "points" : [ {
        "x" : 1300,
        "y" : 522
      } ]
    }, {
      "id" : 17122,
      "points" : [ {
        "x" : 1345,
        "y" : 519
      } ]
    }, {
      "id" : 17118,
      "points" : [ {
        "x" : 1206,
        "y" : 663
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 17115,
      "points" : [ {
        "x" : 1268,
        "y" : 658
      } ]
    }, {
      "id" : 17123,
      "points" : [ {
        "x" : 1395,
        "y" : 521
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 17124,
      "points" : [ {
        "x" : 1378,
        "y" : 655
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17125,
      "points" : [ {
        "x" : 1373,
        "y" : 580
      } ]
    } ]
  }, {
    "id" : 17088,
    "reactomeId" : 10759453,
    "displayName" : "SLC30A8 transports Zn2+ from cytosol to secretory granule",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1143,
      "y" : 359
    },
    "minX" : 1137,
    "maxX" : 1149,
    "minY" : 353,
    "maxY" : 365,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1141,
        "y" : 360
      },
      "to" : {
        "x" : 1143,
        "y" : 359
      }
    }, {
      "from" : {
        "x" : 1143,
        "y" : 359
      },
      "to" : {
        "x" : 1144,
        "y" : 361
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1137,
        "y" : 353
      },
      "b" : {
        "x" : 1149,
        "y" : 365
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1143,
        "y" : 359
      }
    },
    "inputs" : [ {
      "id" : 17085,
      "points" : [ {
        "x" : 1182,
        "y" : 266
      } ]
    }, {
      "id" : 17089,
      "points" : [ {
        "x" : 1153,
        "y" : 406
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 17086,
      "points" : [ {
        "x" : 1112,
        "y" : 395
      } ]
    }, {
      "id" : 17090,
      "points" : [ {
        "x" : 1198,
        "y" : 330
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 17091,
      "points" : [ {
        "x" : 1191,
        "y" : 384
      } ]
    } ]
  }, {
    "id" : 17057,
    "reactomeId" : 10759616,
    "displayName" : "SLC41A1,2 transport Mg2+ from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 437,
      "y" : 752
    },
    "minX" : 431,
    "maxX" : 443,
    "minY" : 701,
    "maxY" : 787,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 437,
        "y" : 787
      },
      "to" : {
        "x" : 437,
        "y" : 752
      }
    }, {
      "from" : {
        "x" : 437,
        "y" : 752
      },
      "to" : {
        "x" : 437,
        "y" : 701
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 441,
        "y" : 708
      },
      "b" : {
        "x" : 437,
        "y" : 701
      },
      "c" : {
        "x" : 433,
        "y" : 708
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 433,
        "y" : 708
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 431,
        "y" : 746
      },
      "b" : {
        "x" : 443,
        "y" : 758
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 437,
        "y" : 752
      }
    },
    "inputs" : [ {
      "id" : 17058
    } ],
    "outputs" : [ {
      "id" : 17059
    } ],
    "catalysts" : [ {
      "id" : 17060,
      "points" : [ {
        "x" : 482,
        "y" : 753
      } ]
    } ]
  }, {
    "id" : 17092,
    "reactomeId" : 10759460,
    "displayName" : "ZnT8 transports zinc into the Golgi apparatus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1323,
      "y" : 374
    },
    "minX" : 1317,
    "maxX" : 1329,
    "minY" : 368,
    "maxY" : 380,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1324,
        "y" : 375
      },
      "to" : {
        "x" : 1323,
        "y" : 374
      }
    }, {
      "from" : {
        "x" : 1323,
        "y" : 374
      },
      "to" : {
        "x" : 1325,
        "y" : 375
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1317,
        "y" : 368
      },
      "b" : {
        "x" : 1329,
        "y" : 380
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1323,
        "y" : 374
      }
    },
    "inputs" : [ {
      "id" : 17085,
      "points" : [ {
        "x" : 1205,
        "y" : 266
      } ]
    }, {
      "id" : 17093,
      "points" : [ {
        "x" : 1479,
        "y" : 478
      }, {
        "x" : 1334,
        "y" : 457
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 17094,
      "points" : [ {
        "x" : 1354,
        "y" : 407
      } ]
    }, {
      "id" : 17090,
      "points" : [ {
        "x" : 1234,
        "y" : 330
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 17095,
      "points" : [ {
        "x" : 1302,
        "y" : 393
      } ]
    } ]
  }, {
    "id" : 17061,
    "reactomeId" : 10759432,
    "displayName" : "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 249,
      "y" : 137
    },
    "minX" : 243,
    "maxX" : 255,
    "minY" : 131,
    "maxY" : 143,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 251,
        "y" : 137
      },
      "to" : {
        "x" : 249,
        "y" : 137
      }
    }, {
      "from" : {
        "x" : 249,
        "y" : 137
      },
      "to" : {
        "x" : 251,
        "y" : 138
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 243,
        "y" : 131
      },
      "b" : {
        "x" : 255,
        "y" : 143
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 249,
        "y" : 137
      }
    },
    "inputs" : [ {
      "id" : 17062,
      "points" : [ {
        "x" : 219,
        "y" : 105
      } ]
    }, {
      "id" : 17063,
      "points" : [ {
        "x" : 280,
        "y" : 38
      } ]
    } ],
    "outputs" : [ {
      "id" : 17064,
      "points" : [ {
        "x" : 310,
        "y" : 189
      } ]
    }, {
      "id" : 17065,
      "points" : [ {
        "x" : 206,
        "y" : 214
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17066,
      "points" : [ {
        "x" : 209,
        "y" : 136
      } ]
    } ]
  }, {
    "id" : 17126,
    "reactomeId" : 10757943,
    "displayName" : "K+-independent Li+/Ca2+ exchanger transport",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1461,
      "y" : 754
    },
    "minX" : 1455,
    "maxX" : 1467,
    "minY" : 748,
    "maxY" : 760,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1462,
        "y" : 753
      },
      "to" : {
        "x" : 1461,
        "y" : 754
      }
    }, {
      "from" : {
        "x" : 1461,
        "y" : 754
      },
      "to" : {
        "x" : 1463,
        "y" : 753
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1455,
        "y" : 748
      },
      "b" : {
        "x" : 1467,
        "y" : 760
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1461,
        "y" : 754
      }
    },
    "inputs" : [ {
      "id" : 17127,
      "points" : [ {
        "x" : 1405,
        "y" : 805
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 17124,
      "points" : [ {
        "x" : 1403,
        "y" : 692
      } ]
    } ],
    "outputs" : [ {
      "id" : 17128,
      "points" : [ {
        "x" : 1482,
        "y" : 697
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 17129,
      "points" : [ {
        "x" : 1473,
        "y" : 805
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17130,
      "points" : [ {
        "x" : 1424,
        "y" : 754
      } ]
    } ]
  }, {
    "id" : 17096,
    "reactomeId" : 10820417,
    "displayName" : "ZnT5 transports zinc into the golgi apparatus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1365,
      "y" : 373
    },
    "minX" : 1210,
    "maxX" : 1371,
    "minY" : 266,
    "maxY" : 407,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1210,
        "y" : 266
      },
      "to" : {
        "x" : 1365,
        "y" : 373
      }
    }, {
      "from" : {
        "x" : 1365,
        "y" : 373
      },
      "to" : {
        "x" : 1367,
        "y" : 407
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1363,
        "y" : 400
      },
      "b" : {
        "x" : 1367,
        "y" : 407
      },
      "c" : {
        "x" : 1371,
        "y" : 400
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1371,
        "y" : 400
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1359,
        "y" : 367
      },
      "b" : {
        "x" : 1371,
        "y" : 379
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1365,
        "y" : 373
      }
    },
    "inputs" : [ {
      "id" : 17085
    } ],
    "outputs" : [ {
      "id" : 17094
    } ],
    "catalysts" : [ {
      "id" : 17097,
      "points" : [ {
        "x" : 1416,
        "y" : 373
      } ]
    } ]
  }, {
    "id" : 17098,
    "reactomeId" : 10759597,
    "displayName" : "SLC39A1-4 transports Zn2+ from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1078,
      "y" : 139
    },
    "minX" : 1072,
    "maxX" : 1173,
    "minY" : 39,
    "maxY" : 229,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1164,
        "y" : 39
      },
      "to" : {
        "x" : 1078,
        "y" : 139
      }
    }, {
      "from" : {
        "x" : 1078,
        "y" : 139
      },
      "to" : {
        "x" : 1173,
        "y" : 229
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1165,
        "y" : 227
      },
      "b" : {
        "x" : 1173,
        "y" : 229
      },
      "c" : {
        "x" : 1171,
        "y" : 221
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1171,
        "y" : 221
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1072,
        "y" : 133
      },
      "b" : {
        "x" : 1084,
        "y" : 145
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1078,
        "y" : 139
      }
    },
    "inputs" : [ {
      "id" : 17099
    } ],
    "outputs" : [ {
      "id" : 17085
    } ],
    "catalysts" : [ {
      "id" : 17100,
      "points" : [ {
        "x" : 1119,
        "y" : 139
      } ]
    } ]
  }, {
    "id" : 17131,
    "reactomeId" : 10757998,
    "displayName" : "Na+/H+ exchanger transport (at cell membrane)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 846,
      "y" : 754
    },
    "minX" : 840,
    "maxX" : 852,
    "minY" : 748,
    "maxY" : 760,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 845,
        "y" : 754
      },
      "to" : {
        "x" : 846,
        "y" : 754
      }
    }, {
      "from" : {
        "x" : 846,
        "y" : 754
      },
      "to" : {
        "x" : 843,
        "y" : 754
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 840,
        "y" : 748
      },
      "b" : {
        "x" : 852,
        "y" : 760
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 846,
        "y" : 754
      }
    },
    "inputs" : [ {
      "id" : 17108,
      "points" : [ {
        "x" : 934,
        "y" : 808
      } ]
    }, {
      "id" : 17132,
      "points" : [ {
        "x" : 836,
        "y" : 707
      } ]
    } ],
    "outputs" : [ {
      "id" : 17110,
      "points" : [ {
        "x" : 927,
        "y" : 688
      } ]
    }, {
      "id" : 17133,
      "points" : [ {
        "x" : 841,
        "y" : 802
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17134,
      "points" : [ {
        "x" : 780,
        "y" : 753
      } ]
    } ]
  }, {
    "id" : 17067,
    "reactomeId" : 10759583,
    "displayName" : "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 462,
      "y" : 138
    },
    "minX" : 456,
    "maxX" : 485,
    "minY" : 39,
    "maxY" : 196,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 459,
        "y" : 196
      },
      "to" : {
        "x" : 462,
        "y" : 138
      }
    }, {
      "from" : {
        "x" : 462,
        "y" : 138
      },
      "to" : {
        "x" : 485,
        "y" : 39
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 487,
        "y" : 47
      },
      "b" : {
        "x" : 485,
        "y" : 39
      },
      "c" : {
        "x" : 480,
        "y" : 45
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 480,
        "y" : 45
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 456,
        "y" : 132
      },
      "b" : {
        "x" : 468,
        "y" : 144
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 462,
        "y" : 138
      }
    },
    "inputs" : [ {
      "id" : 17068
    } ],
    "outputs" : [ {
      "id" : 17069
    } ],
    "catalysts" : [ {
      "id" : 17070,
      "points" : [ {
        "x" : 419,
        "y" : 138
      } ]
    } ]
  }, {
    "id" : 17101,
    "reactomeId" : 10759570,
    "displayName" : "ZIP6 and ZIP14 mediate zinc influx into cells",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1527,
      "y" : 142
    },
    "minX" : 1204,
    "maxX" : 1533,
    "minY" : 27,
    "maxY" : 240,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1204,
        "y" : 27
      },
      "to" : {
        "x" : 1527,
        "y" : 142
      }
    }, {
      "from" : {
        "x" : 1527,
        "y" : 142
      },
      "to" : {
        "x" : 1215,
        "y" : 240
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1220,
        "y" : 234
      },
      "b" : {
        "x" : 1215,
        "y" : 240
      },
      "c" : {
        "x" : 1223,
        "y" : 242
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1223,
        "y" : 242
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1521,
        "y" : 136
      },
      "b" : {
        "x" : 1533,
        "y" : 148
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1527,
        "y" : 142
      }
    },
    "inputs" : [ {
      "id" : 17099
    } ],
    "outputs" : [ {
      "id" : 17085
    } ],
    "catalysts" : [ {
      "id" : 17102,
      "points" : [ {
        "x" : 1558,
        "y" : 141
      } ]
    } ]
  }, {
    "id" : 17103,
    "reactomeId" : 10759590,
    "displayName" : "ZIP8 mediates zinc influx into cells",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 844,
      "y" : 135
    },
    "minX" : 838,
    "maxX" : 850,
    "minY" : 129,
    "maxY" : 141,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 843,
        "y" : 136
      },
      "to" : {
        "x" : 844,
        "y" : 135
      }
    }, {
      "from" : {
        "x" : 844,
        "y" : 135
      },
      "to" : {
        "x" : 845,
        "y" : 136
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 838,
        "y" : 129
      },
      "b" : {
        "x" : 850,
        "y" : 141
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 844,
        "y" : 135
      }
    },
    "inputs" : [ {
      "id" : 17104,
      "points" : [ {
        "x" : 844,
        "y" : 76
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 17099,
      "points" : [ {
        "x" : 1153,
        "y" : 27
      } ]
    } ],
    "outputs" : [ {
      "id" : 17105,
      "points" : [ {
        "x" : 846,
        "y" : 203
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 17085,
      "points" : [ {
        "x" : 1164,
        "y" : 239
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17106,
      "points" : [ {
        "x" : 791,
        "y" : 135
      } ]
    } ]
  }, {
    "id" : 17071,
    "reactomeId" : 10812935,
    "displayName" : "SLC30A10 transports Mn2+ from cytosol to extracellular region",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 179,
      "y" : 753
    },
    "minX" : 173,
    "maxX" : 185,
    "minY" : 747,
    "maxY" : 759,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 179,
        "y" : 752
      },
      "to" : {
        "x" : 179,
        "y" : 753
      }
    }, {
      "from" : {
        "x" : 179,
        "y" : 753
      },
      "to" : {
        "x" : 179,
        "y" : 754
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 173,
        "y" : 747
      },
      "b" : {
        "x" : 185,
        "y" : 759
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 179,
        "y" : 753
      }
    },
    "inputs" : [ {
      "id" : 17072,
      "points" : [ {
        "x" : 179,
        "y" : 696
      } ]
    }, {
      "id" : 17073,
      "points" : [ {
        "x" : 127,
        "y" : 784
      } ]
    } ],
    "outputs" : [ {
      "id" : 17074,
      "points" : [ {
        "x" : 179,
        "y" : 791
      } ]
    }, {
      "id" : 17075,
      "points" : [ {
        "x" : 130,
        "y" : 716
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17076,
      "points" : [ {
        "x" : 143,
        "y" : 753
      } ]
    } ]
  }, {
    "id" : 17135,
    "reactomeId" : 10757973,
    "displayName" : "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 506,
      "y" : 443
    },
    "minX" : 500,
    "maxX" : 512,
    "minY" : 437,
    "maxY" : 449,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 507,
        "y" : 444
      },
      "to" : {
        "x" : 506,
        "y" : 443
      }
    }, {
      "from" : {
        "x" : 506,
        "y" : 443
      },
      "to" : {
        "x" : 507,
        "y" : 445
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 500,
        "y" : 437
      },
      "b" : {
        "x" : 512,
        "y" : 449
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 506,
        "y" : 443
      }
    },
    "inputs" : [ {
      "id" : 17136,
      "points" : [ {
        "x" : 418,
        "y" : 396
      } ]
    }, {
      "id" : 17110,
      "points" : [ {
        "x" : 927,
        "y" : 664
      } ]
    } ],
    "outputs" : [ {
      "id" : 17137,
      "points" : [ {
        "x" : 474,
        "y" : 386
      } ]
    }, {
      "id" : 17138,
      "points" : [ {
        "x" : 568,
        "y" : 498
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17139,
      "points" : [ {
        "x" : 451,
        "y" : 443
      } ]
    } ]
  }, {
    "id" : 17107,
    "reactomeId" : 10757914,
    "displayName" : "SLC8A1,2,3 exchange 3Na+ for Ca2+",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1039,
      "y" : 754
    },
    "minX" : 1033,
    "maxX" : 1045,
    "minY" : 748,
    "maxY" : 760,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1040,
        "y" : 754
      },
      "to" : {
        "x" : 1039,
        "y" : 754
      }
    }, {
      "from" : {
        "x" : 1039,
        "y" : 754
      },
      "to" : {
        "x" : 1041,
        "y" : 754
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1033,
        "y" : 748
      },
      "b" : {
        "x" : 1045,
        "y" : 760
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1039,
        "y" : 754
      }
    },
    "inputs" : [ {
      "id" : 17108,
      "points" : [ {
        "x" : 978,
        "y" : 805
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 17109,
      "points" : [ {
        "x" : 1092,
        "y" : 694
      } ]
    } ],
    "outputs" : [ {
      "id" : 17110,
      "points" : [ {
        "x" : 966,
        "y" : 693
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 17111,
      "points" : [ {
        "x" : 1096,
        "y" : 805
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17112,
      "points" : [ {
        "x" : 985,
        "y" : 754
      } ]
    } ],
    "activators" : [ {
      "id" : 17113,
      "points" : [ {
        "x" : 1048,
        "y" : 636
      } ]
    } ]
  }, {
    "id" : 17140,
    "reactomeId" : 10758009,
    "displayName" : "Na+/H+ exchanger transport (at trans-golgi membrane)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1570,
      "y" : 580
    },
    "minX" : 1564,
    "maxX" : 1576,
    "minY" : 574,
    "maxY" : 586,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1567,
        "y" : 578
      },
      "to" : {
        "x" : 1570,
        "y" : 580
      }
    }, {
      "from" : {
        "x" : 1570,
        "y" : 580
      },
      "to" : {
        "x" : 1568,
        "y" : 577
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1564,
        "y" : 574
      },
      "b" : {
        "x" : 1576,
        "y" : 586
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1570,
        "y" : 580
      }
    },
    "inputs" : [ {
      "id" : 17093,
      "points" : [ {
        "x" : 1508,
        "y" : 500
      } ]
    }, {
      "id" : 17141,
      "points" : [ {
        "x" : 1556,
        "y" : 644
      } ]
    } ],
    "outputs" : [ {
      "id" : 17123,
      "points" : [ {
        "x" : 1436,
        "y" : 511
      } ]
    }, {
      "id" : 17142,
      "points" : [ {
        "x" : 1612,
        "y" : 615
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17143,
      "points" : [ {
        "x" : 1613,
        "y" : 567
      } ]
    } ]
  }, {
    "id" : 17077,
    "reactomeId" : 10763227,
    "displayName" : "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 528,
      "y" : 140
    },
    "minX" : 473,
    "maxX" : 534,
    "minY" : 39,
    "maxY" : 196,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 473,
        "y" : 196
      },
      "to" : {
        "x" : 528,
        "y" : 140
      }
    }, {
      "from" : {
        "x" : 528,
        "y" : 140
      },
      "to" : {
        "x" : 494,
        "y" : 39
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 500,
        "y" : 44
      },
      "b" : {
        "x" : 494,
        "y" : 39
      },
      "c" : {
        "x" : 492,
        "y" : 47
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 492,
        "y" : 47
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 522,
        "y" : 134
      },
      "b" : {
        "x" : 534,
        "y" : 146
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 528,
        "y" : 140
      }
    },
    "inputs" : [ {
      "id" : 17068
    } ],
    "outputs" : [ {
      "id" : 17069
    } ],
    "catalysts" : [ {
      "id" : 17078,
      "points" : [ {
        "x" : 573,
        "y" : 140
      } ]
    } ]
  }, {
    "id" : 17079,
    "reactomeId" : 10759422,
    "displayName" : "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 177,
      "y" : 305
    },
    "minX" : 171,
    "maxX" : 183,
    "minY" : 299,
    "maxY" : 311,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 178,
        "y" : 305
      },
      "to" : {
        "x" : 177,
        "y" : 305
      }
    }, {
      "from" : {
        "x" : 177,
        "y" : 305
      },
      "to" : {
        "x" : 178,
        "y" : 306
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 171,
        "y" : 299
      },
      "b" : {
        "x" : 183,
        "y" : 311
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 177,
        "y" : 305
      }
    },
    "inputs" : [ {
      "id" : 17080,
      "points" : [ {
        "x" : 136,
        "y" : 278
      } ]
    }, {
      "id" : 17081,
      "points" : [ {
        "x" : 235,
        "y" : 349
      } ]
    } ],
    "outputs" : [ {
      "id" : 17082,
      "points" : [ {
        "x" : 159,
        "y" : 348
      } ]
    }, {
      "id" : 17065,
      "points" : [ {
        "x" : 195,
        "y" : 246
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17083,
      "points" : [ {
        "x" : 218,
        "y" : 305
      } ]
    } ]
  }, {
    "id" : 17144,
    "reactomeId" : 10757960,
    "displayName" : "SLC9A9 exchanges Na+ for H+ across the late endosome membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 518,
      "y" : 555
    },
    "minX" : 512,
    "maxX" : 524,
    "minY" : 549,
    "maxY" : 561,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 516,
        "y" : 554
      },
      "to" : {
        "x" : 518,
        "y" : 555
      }
    }, {
      "from" : {
        "x" : 518,
        "y" : 555
      },
      "to" : {
        "x" : 518,
        "y" : 554
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 512,
        "y" : 549
      },
      "b" : {
        "x" : 524,
        "y" : 561
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 518,
        "y" : 555
      }
    },
    "inputs" : [ {
      "id" : 17145,
      "points" : [ {
        "x" : 409,
        "y" : 573
      } ]
    }, {
      "id" : 17110,
      "points" : [ {
        "x" : 927,
        "y" : 668
      } ]
    } ],
    "outputs" : [ {
      "id" : 17146,
      "points" : [ {
        "x" : 460,
        "y" : 538
      } ]
    }, {
      "id" : 17138,
      "points" : [ {
        "x" : 565,
        "y" : 523
      } ]
    } ],
    "catalysts" : [ {
      "id" : 17147,
      "points" : [ {
        "x" : 503,
        "y" : 595
      } ]
    } ]
  }, {
    "id" : 17114,
    "reactomeId" : 10757936,
    "displayName" : "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1185,
      "y" : 752
    },
    "minX" : 1179,
    "maxX" : 1191,
    "minY" : 746,
    "maxY" : 758,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1185,
        "y" : 755
      },
      "to" : {
        "x" : 1185,
        "y" : 752
      }
    }, {
      "from" : {
        "x" : 1185,
        "y" : 752
      },
      "to" : {
        "x" : 1187,
        "y" : 752
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1179,
        "y" : 746
      },
      "b" : {
        "x" : 1191,
        "y" : 758
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1185,
        "y" : 752
      }
    },
    "inputs" : [ {
      "id" : 17115,
      "points" : [ {
        "x" : 1243,
        "y" : 695
      } ]
    }, {
      "id" : 17109,
      "points" : [ {
        "x" : 1120,
        "y" : 694
      } ]
    }, {
      "id" : 17116,
      "points" : [ {
        "x" : 1186,
        "y" : 802
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 17117,
      "points" : [ {
        "x" : 1245,
        "y" : 809
      } ]
    }, {
      "id" : 17111,
      "points" : [ {
        "x" : 1129,
        "y" : 805
      } ]
    }, {
      "id" : 17118,
      "points" : [ {
        "x" : 1184,
        "y" : 695
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 17119,
      "points" : [ {
        "x" : 1251,
        "y" : 754
      } ]
    } ]
  }, {
    "id" : 17148,
    "reactomeId" : 10759439,
    "displayName" : "ZnT1 mediates the efflux of zinc from the cell",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1680,
      "y" : 139
    },
    "minX" : 1674,
    "maxX" : 1686,
    "minY" : 133,
    "maxY" : 145,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1681,
        "y" : 140
      },
      "to" : {
        "x" : 1680,
        "y" : 139
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1674,
        "y" : 133
      },
      "b" : {
        "x" : 1686,
        "y" : 145
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1680,
        "y" : 139
      }
    },
    "inputs" : [ {
      "id" : 17085,
      "points" : [ {
        "x" : 1215,
        "y" : 243
      }, {
        "x" : 1626,
        "y" : 177
      } ]
    }, {
      "id" : 17149,
      "points" : [ {
        "x" : 1680,
        "y" : 90
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 17099,
      "points" : [ {
        "x" : 1204,
        "y" : 23
      }, {
        "x" : 1622,
        "y" : 91
      } ]
    }, {
      "id" : 17150,
      "points" : [ {
        "x" : 1681,
        "y" : 187
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 17151,
      "points" : [ {
        "x" : 1714,
        "y" : 138
      } ]
    } ]
  }, {
    "id" : 17084,
    "reactomeId" : 10759446,
    "displayName" : "ZnT5 transports zinc into secretory granules in pancreatic beta cells",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1097,
      "y" : 365
    },
    "minX" : 1091,
    "maxX" : 1176,
    "minY" : 266,
    "maxY" : 395,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1176,
        "y" : 266
      },
      "to" : {
        "x" : 1097,
        "y" : 365
      }
    }, {
      "from" : {
        "x" : 1097,
        "y" : 365
      },
      "to" : {
        "x" : 1098,
        "y" : 395
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1094,
        "y" : 388
      },
      "b" : {
        "x" : 1098,
        "y" : 395
      },
      "c" : {
        "x" : 1102,
        "y" : 388
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1102,
        "y" : 388
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1091,
        "y" : 359
      },
      "b" : {
        "x" : 1103,
        "y" : 371
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1097,
        "y" : 365
      }
    },
    "inputs" : [ {
      "id" : 17085
    } ],
    "outputs" : [ {
      "id" : 17086
    } ],
    "catalysts" : [ {
      "id" : 17087,
      "points" : [ {
        "x" : 1056,
        "y" : 366
      } ]
    } ]
  }, {
    "id" : 17053,
    "reactomeId" : 10759478,
    "displayName" : "SLC31A1 transports Cu1+ from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 264,
      "y" : 755
    },
    "minX" : 258,
    "maxX" : 270,
    "minY" : 692,
    "maxY" : 794,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 264,
        "y" : 794
      },
      "to" : {
        "x" : 264,
        "y" : 755
      }
    }, {
      "from" : {
        "x" : 264,
        "y" : 755
      },
      "to" : {
        "x" : 263,
        "y" : 692
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 267,
        "y" : 699
      },
      "b" : {
        "x" : 263,
        "y" : 692
      },
      "c" : {
        "x" : 259,
        "y" : 699
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 259,
        "y" : 699
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 258,
        "y" : 749
      },
      "b" : {
        "x" : 270,
        "y" : 761
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 264,
        "y" : 755
      }
    },
    "inputs" : [ {
      "id" : 17054
    } ],
    "outputs" : [ {
      "id" : 17055
    } ],
    "catalysts" : [ {
      "id" : 17056,
      "points" : [ {
        "x" : 313,
        "y" : 753
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 17152,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 887,
      "y" : 446
    },
    "minX" : 0,
    "maxX" : 1775,
    "minY" : 133,
    "maxY" : 760,
    "prop" : {
      "x" : 0,
      "y" : 133,
      "width" : 1775,
      "height" : 627
    },
    "textPosition" : {
      "x" : 436,
      "y" : 250
    },
    "insets" : {
      "x" : 10,
      "y" : 143,
      "width" : 1755,
      "height" : 607
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 17053, 17060, 17071, 17056, 17059, 17066, 17076, 17153, 17065, 17080, 17061, 17067, 17070, 17077, 17072, 17057, 17085, 17155, 17157, 17158, 17159, 17098, 17100, 17102, 17101, 17103, 17106, 17161, 17078, 17075, 17090, 17105, 17107, 17110, 17112, 17109, 17113, 17119, 17115, 17118, 17114, 17124, 17128, 17130, 17126, 17134, 17131, 17132, 17165, 17064, 17068, 17141, 17142, 17166, 17138, 17151, 17148, 17150, 17055 ]
  }, {
    "id" : 17153,
    "reactomeId" : 1222282,
    "displayName" : "phagocytic vesicle lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 188,
      "y" : 392
    },
    "minX" : 48,
    "maxX" : 328,
    "minY" : 301,
    "maxY" : 483,
    "prop" : {
      "x" : 48,
      "y" : 301,
      "width" : 280,
      "height" : 182
    },
    "textPosition" : {
      "x" : 138,
      "y" : 439
    },
    "insets" : {
      "x" : 58,
      "y" : 311,
      "width" : 260,
      "height" : 162
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 17083, 17081, 17082, 17079 ]
  }, {
    "id" : 17155,
    "reactomeId" : 171907,
    "displayName" : "endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 623,
      "y" : 304
    },
    "minX" : 536,
    "maxX" : 711,
    "minY" : 220,
    "maxY" : 389,
    "prop" : {
      "x" : 536,
      "y" : 220,
      "width" : 175,
      "height" : 169
    },
    "textPosition" : {
      "x" : 569,
      "y" : 337
    },
    "insets" : {
      "x" : 546,
      "y" : 230,
      "width" : 155,
      "height" : 149
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 17157,
    "reactomeId" : 20600,
    "displayName" : "synaptic vesicle",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 846,
      "y" : 426
    },
    "minX" : 721,
    "maxX" : 971,
    "minY" : 352,
    "maxY" : 500,
    "prop" : {
      "x" : 721,
      "y" : 352,
      "width" : 250,
      "height" : 148
    },
    "textPosition" : {
      "x" : 748,
      "y" : 442
    },
    "insets" : {
      "x" : 731,
      "y" : 362,
      "width" : 230,
      "height" : 128
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 17158,
    "reactomeId" : 1462052,
    "displayName" : "secretory granule lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1108,
      "y" : 428
    },
    "minX" : 1001,
    "maxX" : 1215,
    "minY" : 357,
    "maxY" : 500,
    "prop" : {
      "x" : 1001,
      "y" : 357,
      "width" : 214,
      "height" : 143
    },
    "textPosition" : {
      "x" : 1045,
      "y" : 445
    },
    "insets" : {
      "x" : 1011,
      "y" : 367,
      "width" : 194,
      "height" : 123
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 17087, 17084, 17086, 17088, 17091, 17089 ]
  }, {
    "id" : 17159,
    "reactomeId" : 17963,
    "displayName" : "Golgi lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1449,
      "y" : 476
    },
    "minX" : 1257,
    "maxX" : 1642,
    "minY" : 367,
    "maxY" : 585,
    "prop" : {
      "x" : 1257,
      "y" : 367,
      "width" : 385,
      "height" : 218
    },
    "textPosition" : {
      "x" : 1407,
      "y" : 410
    },
    "insets" : {
      "x" : 1267,
      "y" : 377,
      "width" : 365,
      "height" : 198
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 17094, 17095, 17092, 17097, 17096, 17093, 17121, 17122, 17123, 17125, 17120, 17143, 17140 ]
  }, {
    "id" : 17161,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1540,
      "y" : 275
    },
    "minX" : 1457,
    "maxX" : 1623,
    "minY" : 212,
    "maxY" : 339,
    "prop" : {
      "x" : 1457,
      "y" : 212,
      "width" : 166,
      "height" : 127
    },
    "textPosition" : {
      "x" : 1466,
      "y" : 279
    },
    "insets" : {
      "x" : 1467,
      "y" : 222,
      "width" : 146,
      "height" : 107
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 17165,
    "reactomeId" : 171043,
    "displayName" : "early endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 432,
      "y" : 369
    },
    "minX" : 345,
    "maxX" : 520,
    "minY" : 286,
    "maxY" : 452,
    "prop" : {
      "x" : 345,
      "y" : 286,
      "width" : 175,
      "height" : 166
    },
    "textPosition" : {
      "x" : 363,
      "y" : 299
    },
    "insets" : {
      "x" : 355,
      "y" : 296,
      "width" : 155,
      "height" : 146
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 17139, 17136, 17137, 17135 ]
  }, {
    "id" : 17166,
    "reactomeId" : 173031,
    "displayName" : "late endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 432,
      "y" : 548
    },
    "minX" : 342,
    "maxX" : 523,
    "minY" : 478,
    "maxY" : 619,
    "prop" : {
      "x" : 342,
      "y" : 478,
      "width" : 181,
      "height" : 141
    },
    "textPosition" : {
      "x" : 363,
      "y" : 492
    },
    "insets" : {
      "x" : 352,
      "y" : 488,
      "width" : 161,
      "height" : 121
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 17147, 17144, 17145, 17146 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 17168,
    "reactomeId" : 10826835,
    "displayName" : "Sodium/Proton exchangers",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1026,
      "y" : 594
    },
    "minX" : 364,
    "maxX" : 1688,
    "minY" : 342,
    "maxY" : 846,
    "prop" : {
      "x" : 364,
      "y" : 507,
      "width" : 525,
      "height" : 339
    },
    "points" : [ {
      "x" : 364,
      "y" : 342
    }, {
      "x" : 1688,
      "y" : 342
    }, {
      "x" : 1688,
      "y" : 846
    }, {
      "x" : 364,
      "y" : 846
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 17169,
    "reactomeId" : 10826903,
    "displayName" : "Zinc transporters",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1237,
      "y" : 251
    },
    "minX" : 689,
    "maxX" : 1786,
    "minY" : -5,
    "maxY" : 507,
    "prop" : {
      "x" : 689,
      "y" : -5,
      "width" : 1097,
      "height" : 347
    },
    "points" : [ {
      "x" : 689,
      "y" : -5
    }, {
      "x" : 1786,
      "y" : -5
    }, {
      "x" : 1786,
      "y" : 507
    }, {
      "x" : 689,
      "y" : 507
    } ],
    "colour" : "#008000"
  }, {
    "id" : 17167,
    "reactomeId" : 10826831,
    "displayName" : "Sodium/Calcium exchangers",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1201,
      "y" : 662
    },
    "minX" : 889,
    "maxX" : 1513,
    "minY" : 475,
    "maxY" : 850,
    "prop" : {
      "x" : 889,
      "y" : 475,
      "width" : 624,
      "height" : 375
    },
    "points" : [ {
      "x" : 889,
      "y" : 475
    }, {
      "x" : 1513,
      "y" : 475
    }, {
      "x" : 1513,
      "y" : 850
    }, {
      "x" : 889,
      "y" : 850
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1782,
  "minY" : 0,
  "maxY" : 840,
  "disease" : false
}