{
  "dbId" : 10826427,
  "stableId" : "R-GGA-1566977",
  "displayName" : "Fibronectin matrix formation",
  "nodes" : [ {
    "id" : 110019,
    "reactomeId" : 10748924,
    "displayName" : "FN1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 221,
      "y" : 79
    },
    "minX" : 179,
    "maxX" : 294,
    "minY" : 58,
    "maxY" : 104,
    "prop" : {
      "x" : 179,
      "y" : 64,
      "width" : 84,
      "height" : 31
    },
    "textPosition" : {
      "x" : 185,
      "y" : 74
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 263,
          "y" : 64
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 263,
          "y" : 64
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110017,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110020,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 266,
          "y" : 93
        },
        "to" : {
          "x" : 294,
          "y" : 104
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110018,
    "reactomeId" : 10748922,
    "displayName" : "FN1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 54,
      "y" : 20
    },
    "minX" : 0,
    "maxX" : 299,
    "minY" : 0,
    "maxY" : 272,
    "prop" : {
      "x" : 0,
      "y" : 6,
      "width" : 109,
      "height" : 28
    },
    "textPosition" : {
      "x" : 38,
      "y" : 9
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 109,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 109,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110017,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 111,
            "y" : 40
          },
          "b" : {
            "x" : 123,
            "y" : 52
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 117,
            "y" : 46
          }
        }
      }
    }, {
      "edgeId" : 110025,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 67,
          "y" : 37
        },
        "to" : {
          "x" : 299,
          "y" : 272
        }
      } ],
      "stoichiometry" : {
        "value" : 10,
        "shape" : {
          "a" : {
            "x" : 177,
            "y" : 148
          },
          "b" : {
            "x" : 189,
            "y" : 160
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 183,
            "y" : 154
          }
        }
      }
    }, {
      "edgeId" : 110027,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 63,
          "y" : 37
        },
        "to" : {
          "x" : 180,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110021,
    "reactomeId" : 266099,
    "displayName" : "Mn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 292,
      "y" : 40
    },
    "minX" : 265,
    "maxX" : 321,
    "minY" : 23,
    "maxY" : 104,
    "prop" : {
      "x" : 265,
      "y" : 24,
      "width" : 55,
      "height" : 33
    },
    "textPosition" : {
      "x" : 270,
      "y" : 30
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 315,
          "y" : 29
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 315,
          "y" : 29
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110020,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 292,
          "y" : 60
        },
        "to" : {
          "x" : 294,
          "y" : 104
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110023,
    "reactomeId" : 10748932,
    "displayName" : "Integrin alpha5beta1:FN1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 298,
      "y" : 172
    },
    "minX" : 230,
    "maxX" : 372,
    "minY" : 148,
    "maxY" : 272,
    "prop" : {
      "x" : 230,
      "y" : 154,
      "width" : 136,
      "height" : 36
    },
    "textPosition" : {
      "x" : 238,
      "y" : 141
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 366,
          "y" : 154
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 366,
          "y" : 154
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110020,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110025,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 298,
          "y" : 193
        },
        "to" : {
          "x" : 299,
          "y" : 272
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110022,
    "reactomeId" : 10748930,
    "displayName" : "Integrin alpha5beta1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 386,
      "y" : 76
    },
    "minX" : 294,
    "maxX" : 468,
    "minY" : 58,
    "maxY" : 104,
    "prop" : {
      "x" : 310,
      "y" : 64,
      "width" : 152,
      "height" : 24
    },
    "textPosition" : {
      "x" : 316,
      "y" : 67
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 462,
          "y" : 64
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 462,
          "y" : 64
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110020,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 346,
          "y" : 91
        },
        "to" : {
          "x" : 294,
          "y" : 104
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110024,
    "reactomeId" : 10748902,
    "displayName" : "CEACAM heterodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 225,
      "y" : 120
    },
    "minX" : 183,
    "maxX" : 287,
    "minY" : 95,
    "maxY" : 139,
    "prop" : {
      "x" : 183,
      "y" : 101,
      "width" : 84,
      "height" : 38
    },
    "textPosition" : {
      "x" : 185,
      "y" : 90
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 267,
          "y" : 101
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 267,
          "y" : 101
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110020,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 270,
          "y" : 122
        },
        "to" : {
          "x" : 287,
          "y" : 124
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 280,
          "y" : 127
        },
        "b" : {
          "x" : 287,
          "y" : 124
        },
        "c" : {
          "x" : 281,
          "y" : 119
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 281,
          "y" : 119
        }
      }
    } ]
  }, {
    "id" : 110026,
    "reactomeId" : 10781320,
    "displayName" : "Integrin alpha5beta1:Fibronectin matrix",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 298,
      "y" : 351
    },
    "minX" : 226,
    "maxX" : 376,
    "minY" : 324,
    "maxY" : 372,
    "prop" : {
      "x" : 226,
      "y" : 330,
      "width" : 144,
      "height" : 42
    },
    "textPosition" : {
      "x" : 226,
      "y" : 337
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 370,
          "y" : 330
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 370,
          "y" : 330
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110025,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110029,
    "reactomeId" : 10781306,
    "displayName" : "FN1(32-2386):Collagen types I-V, VII",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 173,
      "y" : 400
    },
    "minX" : 50,
    "maxX" : 303,
    "minY" : 380,
    "maxY" : 415,
    "prop" : {
      "x" : 50,
      "y" : 386,
      "width" : 247,
      "height" : 29
    },
    "textPosition" : {
      "x" : 58,
      "y" : 394
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 297,
          "y" : 386
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 297,
          "y" : 386
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110027,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110028,
    "reactomeId" : 10781304,
    "displayName" : "Collagen types I-V, VII",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 100,
      "y" : 201
    },
    "minX" : 55,
    "maxX" : 180,
    "minY" : 183,
    "maxY" : 220,
    "prop" : {
      "x" : 55,
      "y" : 183,
      "width" : 90,
      "height" : 37
    },
    "textPosition" : {
      "x" : 58,
      "y" : 184
    },
    "connectors" : [ {
      "edgeId" : 110027,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 151,
          "y" : 202
        },
        "to" : {
          "x" : 180,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 110017,
    "reactomeId" : 10782410,
    "displayName" : "FN1 dimerizes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 146,
      "y" : 56
    },
    "minX" : 89,
    "maxX" : 176,
    "minY" : 37,
    "maxY" : 66,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 89,
        "y" : 37
      },
      "to" : {
        "x" : 146,
        "y" : 56
      }
    }, {
      "from" : {
        "x" : 146,
        "y" : 56
      },
      "to" : {
        "x" : 176,
        "y" : 66
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 168,
        "y" : 68
      },
      "b" : {
        "x" : 176,
        "y" : 66
      },
      "c" : {
        "x" : 171,
        "y" : 60
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 171,
        "y" : 60
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 146,
        "y" : 56
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 146,
        "y" : 56
      }
    },
    "inputs" : [ {
      "id" : 110018,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 110019
    } ]
  }, {
    "id" : 110020,
    "reactomeId" : 10748934,
    "displayName" : "Integrin alpha5beta1 binds FN1 dimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 296,
      "y" : 125
    },
    "minX" : 290,
    "maxX" : 302,
    "minY" : 104,
    "maxY" : 151,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 294,
        "y" : 104
      },
      "to" : {
        "x" : 296,
        "y" : 125
      }
    }, {
      "from" : {
        "x" : 296,
        "y" : 125
      },
      "to" : {
        "x" : 297,
        "y" : 151
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 293,
        "y" : 144
      },
      "b" : {
        "x" : 297,
        "y" : 151
      },
      "c" : {
        "x" : 301,
        "y" : 144
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 301,
        "y" : 144
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 296,
        "y" : 125
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 296,
        "y" : 125
      }
    },
    "inputs" : [ {
      "id" : 110019,
      "points" : [ {
        "x" : 266,
        "y" : 93
      } ]
    }, {
      "id" : 110021,
      "points" : [ {
        "x" : 292,
        "y" : 60
      } ]
    }, {
      "id" : 110022,
      "points" : [ {
        "x" : 346,
        "y" : 91
      } ]
    } ],
    "outputs" : [ {
      "id" : 110023
    } ],
    "activators" : [ {
      "id" : 110024,
      "points" : [ {
        "x" : 270,
        "y" : 122
      } ]
    } ]
  }, {
    "id" : 110025,
    "reactomeId" : 10781322,
    "displayName" : "FN1 aggregation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 300,
      "y" : 298
    },
    "minX" : 294,
    "maxX" : 306,
    "minY" : 272,
    "maxY" : 327,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 299,
        "y" : 272
      },
      "to" : {
        "x" : 300,
        "y" : 298
      }
    }, {
      "from" : {
        "x" : 300,
        "y" : 298
      },
      "to" : {
        "x" : 298,
        "y" : 327
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 294,
        "y" : 320
      },
      "b" : {
        "x" : 298,
        "y" : 327
      },
      "c" : {
        "x" : 302,
        "y" : 320
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 302,
        "y" : 320
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 294,
        "y" : 292
      },
      "b" : {
        "x" : 306,
        "y" : 304
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 300,
        "y" : 298
      }
    },
    "inputs" : [ {
      "id" : 110018,
      "points" : [ {
        "x" : 67,
        "y" : 37
      } ],
      "stoichiometry" : 10
    }, {
      "id" : 110023,
      "points" : [ {
        "x" : 298,
        "y" : 193
      } ]
    } ],
    "outputs" : [ {
      "id" : 110026
    } ]
  }, {
    "id" : 110027,
    "reactomeId" : 10781308,
    "displayName" : "FN1 binds Collagen types I-V, VII",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 179,
      "y" : 287
    },
    "minX" : 173,
    "maxX" : 185,
    "minY" : 203,
    "maxY" : 383,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 180,
        "y" : 203
      },
      "to" : {
        "x" : 179,
        "y" : 287
      }
    }, {
      "from" : {
        "x" : 179,
        "y" : 287
      },
      "to" : {
        "x" : 173,
        "y" : 383
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 169,
        "y" : 376
      },
      "b" : {
        "x" : 173,
        "y" : 383
      },
      "c" : {
        "x" : 177,
        "y" : 376
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 177,
        "y" : 376
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 179,
        "y" : 287
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 179,
        "y" : 287
      }
    },
    "inputs" : [ {
      "id" : 110018,
      "points" : [ {
        "x" : 63,
        "y" : 37
      } ]
    }, {
      "id" : 110028,
      "points" : [ {
        "x" : 151,
        "y" : 202
      } ]
    } ],
    "outputs" : [ {
      "id" : 110029
    } ]
  } ],
  "compartments" : [ {
    "id" : 110030,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 402,
      "y" : 257
    },
    "minX" : 308,
    "maxX" : 497,
    "minY" : 78,
    "maxY" : 436,
    "prop" : {
      "x" : 308,
      "y" : 78,
      "width" : 189,
      "height" : 358
    },
    "textPosition" : {
      "x" : 336,
      "y" : 373
    },
    "insets" : {
      "x" : 318,
      "y" : 88,
      "width" : 169,
      "height" : 338
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 110022, 110023, 110026 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 497,
  "minY" : 0,
  "maxY" : 436,
  "disease" : false
}