{
  "dbId" : 10731414,
  "stableId" : "R-XTR-400206",
  "displayName" : "Regulation of lipid metabolism by PPARalpha",
  "nodes" : [ {
    "id" : 94187,
    "reactomeId" : 10703842,
    "displayName" : "AHR:TCDD:ARNT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 119,
      "y" : 1450
    },
    "minX" : 65,
    "maxX" : 180,
    "minY" : 1433,
    "maxY" : 1462,
    "prop" : {
      "x" : 65,
      "y" : 1439,
      "width" : 109,
      "height" : 23
    },
    "textPosition" : {
      "x" : 66,
      "y" : 1441
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 174,
          "y" : 1439
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 174,
          "y" : 1439
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 94155,
    "reactomeId" : 9734495,
    "displayName" : "fibrates",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 187,
      "y" : 441
    },
    "minX" : 153,
    "maxX" : 238,
    "minY" : 396,
    "maxY" : 451,
    "prop" : {
      "x" : 153,
      "y" : 432,
      "width" : 68,
      "height" : 19
    },
    "textPosition" : {
      "x" : 159,
      "y" : 431
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 94154,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 197,
          "y" : 426
        },
        "to" : {
          "x" : 238,
          "y" : 396
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 94189,
    "reactomeId" : 10731170,
    "displayName" : "Aryl hydrocarbon receptor signalling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 130,
      "y" : 1384
    },
    "minX" : 59,
    "maxX" : 201,
    "minY" : 1360,
    "maxY" : 1408,
    "prop" : {
      "x" : 59,
      "y" : 1360,
      "width" : 142,
      "height" : 48
    },
    "textPosition" : {
      "x" : 63,
      "y" : 1362
    },
    "connectors" : [ ]
  }, {
    "id" : 94157,
    "reactomeId" : 10672496,
    "displayName" : "Corepressors of PPARalpha",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 215,
      "y" : 255
    },
    "minX" : 163,
    "maxX" : 268,
    "minY" : 237,
    "maxY" : 341,
    "prop" : {
      "x" : 163,
      "y" : 237,
      "width" : 105,
      "height" : 37
    },
    "textPosition" : {
      "x" : 167,
      "y" : 238
    },
    "connectors" : [ {
      "edgeId" : 94154,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 219,
          "y" : 280
        },
        "to" : {
          "x" : 237,
          "y" : 341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 225,
          "y" : 286
        },
        "b" : {
          "x" : 219,
          "y" : 280
        },
        "c" : {
          "x" : 217,
          "y" : 288
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 217,
          "y" : 288
        }
      }
    } ]
  }, {
    "id" : 94188,
    "reactomeId" : 10703848,
    "displayName" : "AHRR:ARNT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 213,
      "y" : 1475
    },
    "minX" : 184,
    "maxX" : 248,
    "minY" : 1452,
    "maxY" : 1493,
    "prop" : {
      "x" : 184,
      "y" : 1458,
      "width" : 58,
      "height" : 35
    },
    "textPosition" : {
      "x" : 190,
      "y" : 1458
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 242,
          "y" : 1458
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 242,
          "y" : 1458
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 94156,
    "reactomeId" : 10672510,
    "displayName" : "PPARA:RXRA:Corepressors",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 342,
      "y" : 377
    },
    "minX" : 238,
    "maxX" : 395,
    "minY" : 351,
    "maxY" : 397,
    "prop" : {
      "x" : 295,
      "y" : 357,
      "width" : 94,
      "height" : 40
    },
    "textPosition" : {
      "x" : 296,
      "y" : 362
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 389,
          "y" : 357
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 389,
          "y" : 357
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 94154,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 292,
          "y" : 385
        },
        "to" : {
          "x" : 238,
          "y" : 396
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 94158,
    "reactomeId" : 10723612,
    "displayName" : "PPARA:RXRA:fibrates",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 166,
      "y" : 328
    },
    "minX" : 122,
    "maxX" : 237,
    "minY" : 305,
    "maxY" : 346,
    "prop" : {
      "x" : 122,
      "y" : 311,
      "width" : 88,
      "height" : 35
    },
    "textPosition" : {
      "x" : 122,
      "y" : 311
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 210,
          "y" : 311
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 210,
          "y" : 311
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 94154,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 213,
          "y" : 336
        },
        "to" : {
          "x" : 237,
          "y" : 341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 221,
          "y" : 333
        },
        "b" : {
          "x" : 213,
          "y" : 336
        },
        "c" : {
          "x" : 219,
          "y" : 341
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 219,
          "y" : 341
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 94154,
    "reactomeId" : 10723614,
    "displayName" : "PPARA binds fibrates",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 237,
      "y" : 368
    },
    "minX" : 231,
    "maxX" : 243,
    "minY" : 335,
    "maxY" : 396,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 238,
        "y" : 396
      },
      "to" : {
        "x" : 237,
        "y" : 368
      }
    }, {
      "from" : {
        "x" : 237,
        "y" : 368
      },
      "to" : {
        "x" : 237,
        "y" : 341
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 231,
        "y" : 362
      },
      "b" : {
        "x" : 243,
        "y" : 374
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 237,
        "y" : 368
      }
    },
    "inputs" : [ {
      "id" : 94155,
      "points" : [ {
        "x" : 197,
        "y" : 426
      } ]
    }, {
      "id" : 94156,
      "points" : [ {
        "x" : 292,
        "y" : 385
      } ]
    } ],
    "outputs" : [ {
      "id" : 94157,
      "points" : [ {
        "x" : 219,
        "y" : 280
      } ]
    }, {
      "id" : 94158,
      "points" : [ {
        "x" : 213,
        "y" : 336
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 94161,
    "reactomeId" : 13977,
    "displayName" : "lipid droplet",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 93,
      "y" : 1850
    },
    "minX" : 33,
    "maxX" : 153,
    "minY" : 1780,
    "maxY" : 1921,
    "prop" : {
      "x" : 33,
      "y" : 1780,
      "width" : 120,
      "height" : 141
    },
    "textPosition" : {
      "x" : 47,
      "y" : 1848
    },
    "insets" : {
      "x" : 43,
      "y" : 1790,
      "width" : 100,
      "height" : 121
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 94160,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 568,
      "y" : 866
    },
    "minX" : 29,
    "maxX" : 1108,
    "minY" : 53,
    "maxY" : 1679,
    "prop" : {
      "x" : 29,
      "y" : 53,
      "width" : 1079,
      "height" : 1626
    },
    "textPosition" : {
      "x" : 42,
      "y" : 672
    },
    "insets" : {
      "x" : 39,
      "y" : 63,
      "width" : 1059,
      "height" : 1606
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 94157, 94156, 94187, 94188, 94189, 94190, 94191, 94154, 94155, 94158 ]
  }, {
    "id" : 94163,
    "reactomeId" : 17906,
    "displayName" : "mitochondrial outer membrane",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1246,
      "y" : 1558
    },
    "minX" : 1138,
    "maxX" : 1354,
    "minY" : 1435,
    "maxY" : 1681,
    "prop" : {
      "x" : 1138,
      "y" : 1435,
      "width" : 216,
      "height" : 246
    },
    "textPosition" : {
      "x" : 1137,
      "y" : 1621
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 94162,
    "reactomeId" : 5460,
    "displayName" : "mitochondrial matrix",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 810,
      "y" : 1847
    },
    "minX" : 657,
    "maxX" : 964,
    "minY" : 1769,
    "maxY" : 1925,
    "prop" : {
      "x" : 657,
      "y" : 1769,
      "width" : 307,
      "height" : 156
    },
    "textPosition" : {
      "x" : 735,
      "y" : 1876
    },
    "insets" : {
      "x" : 667,
      "y" : 1779,
      "width" : 287,
      "height" : 136
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 94164,
    "reactomeId" : 17951,
    "displayName" : "peroxisomal matrix",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1086,
      "y" : 1851
    },
    "minX" : 982,
    "maxX" : 1191,
    "minY" : 1773,
    "maxY" : 1929,
    "prop" : {
      "x" : 982,
      "y" : 1773,
      "width" : 209,
      "height" : 156
    },
    "textPosition" : {
      "x" : 1044,
      "y" : 1878
    },
    "insets" : {
      "x" : 992,
      "y" : 1783,
      "width" : 189,
      "height" : 136
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 94171,
    "reactomeId" : 12045,
    "displayName" : "endoplasmic reticulum membrane",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 403,
      "y" : 1851
    },
    "minX" : 172,
    "maxX" : 634,
    "minY" : 1781,
    "maxY" : 1921,
    "prop" : {
      "x" : 172,
      "y" : 1781,
      "width" : 462,
      "height" : 140
    },
    "textPosition" : {
      "x" : 399,
      "y" : 1885
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 94159,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 720,
      "y" : 980
    },
    "minX" : 0,
    "maxX" : 1441,
    "minY" : 0,
    "maxY" : 1961,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1441,
      "height" : 1961
    },
    "textPosition" : {
      "x" : 18,
      "y" : 1737
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1421,
      "height" : 1941
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 94160, 94161, 94163, 94162, 94164, 94171 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 94191,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 174,
      "y" : 1433
    },
    "minX" : 152,
    "maxX" : 196,
    "minY" : 1411,
    "maxY" : 1455,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 152,
        "y" : 1411
      },
      "to" : {
        "x" : 196,
        "y" : 1455
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 188,
        "y" : 1453
      },
      "b" : {
        "x" : 196,
        "y" : 1455
      },
      "c" : {
        "x" : 194,
        "y" : 1447
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 194,
        "y" : 1447
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 168,
        "y" : 1427
      },
      "b" : {
        "x" : 180,
        "y" : 1439
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 174,
        "y" : 1433
      }
    },
    "inputs" : [ {
      "id" : 94189
    } ],
    "outputs" : [ {
      "id" : 94188
    } ]
  }, {
    "id" : 94190,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 122,
      "y" : 1423
    },
    "minX" : 116,
    "maxX" : 128,
    "minY" : 1411,
    "maxY" : 1436,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 125,
        "y" : 1411
      },
      "to" : {
        "x" : 120,
        "y" : 1436
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 117,
        "y" : 1428
      },
      "b" : {
        "x" : 120,
        "y" : 1436
      },
      "c" : {
        "x" : 125,
        "y" : 1430
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 125,
        "y" : 1430
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 116,
        "y" : 1417
      },
      "b" : {
        "x" : 128,
        "y" : 1429
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 122,
        "y" : 1423
      }
    },
    "inputs" : [ {
      "id" : 94189
    } ],
    "outputs" : [ {
      "id" : 94187
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1441,
  "minY" : 0,
  "maxY" : 1961,
  "disease" : false
}