{
  "dbId" : 10730236,
  "stId" : "R-XTR-9958825",
  "speciesName" : "Xenopus tropicalis",
  "nodes" : [ {
    "dbId" : 10680739,
    "stId" : "R-XTR-1112570",
    "displayName" : "IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10680741 ],
    "children" : [ 10680735, 10680676 ]
  }, {
    "dbId" : 74112,
    "stId" : "R-ALL-74112",
    "displayName" : "Ca2+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 116215 ],
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10727344 ],
    "children" : [ ]
  }, {
    "dbId" : 10727330,
    "stId" : "R-XTR-9913263",
    "displayName" : "F-actin (all) [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 205621,
    "diagramIds" : [ 116222 ],
    "parents" : [ 10727342, 10727338, 10727334 ],
    "children" : [ 10727328 ]
  }, {
    "dbId" : 10680737,
    "stId" : "R-XTR-1112585",
    "displayName" : "IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10680741 ],
    "children" : [ 10680735, 10680691 ]
  }, {
    "dbId" : 10727328,
    "stId" : "R-XTR-9913261",
    "displayName" : "actins:ATP [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10727330 ],
    "children" : [ 10727326, 113592 ]
  }, {
    "dbId" : 10680743,
    "stId" : "R-XTR-1112594",
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116196 ],
    "parents" : [ 10728182, 10728184 ],
    "children" : [ 10680741 ]
  }, {
    "dbId" : 10727334,
    "stId" : "R-XTR-9934481",
    "displayName" : "Homotypic CDH1 cis-cluster:F-actin [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116223 ],
    "parents" : [ 10727340 ],
    "children" : [ 10727332, 10727330 ]
  }, {
    "dbId" : 9681301,
    "stId" : "R-ALL-9681301",
    "displayName" : "tocilizumab [extracellular region]",
    "schemaClass" : "ProteinDrug",
    "speciesId" : 0,
    "identifier" : "6881",
    "standardIdentifier" : "iuphar.ligand:6881",
    "parents" : [ 9715042 ],
    "children" : [ ]
  }, {
    "dbId" : 10680741,
    "stId" : "R-XTR-1112584",
    "displayName" : "IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10680743 ],
    "children" : [ 10680737, 10680739 ]
  }, {
    "dbId" : 10727332,
    "stId" : "R-XTR-9934413",
    "displayName" : "Homotypic CDH1 cis-cluster [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116220 ],
    "parents" : [ 10727334 ],
    "children" : [ 10724985 ]
  }, {
    "dbId" : 10727338,
    "stId" : "R-XTR-9934440",
    "displayName" : "trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116216 ],
    "parents" : [ ],
    "children" : [ 10724985, 10675446, 10727330 ]
  }, {
    "dbId" : 10669230,
    "stId" : "R-XTR-1810408",
    "displayName" : "phospho-MyrG-p-Y419-SRC [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 116213 ],
    "identifier" : "A0A8J0T467",
    "standardIdentifier" : "uniprot:A0A8J0T467",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10680750,
    "stId" : "R-XTR-914048",
    "displayName" : "phospho-stat3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 116205 ],
    "identifier" : "A0A803J6M0",
    "standardIdentifier" : "uniprot:A0A803J6M0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "stat3" ],
    "parents" : [ 10728184 ],
    "children" : [ ]
  }, {
    "dbId" : 10727342,
    "stId" : "R-XTR-9934508",
    "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10727344 ],
    "children" : [ 10724985, 10675446, 10727330 ]
  }, {
    "dbId" : 10727340,
    "stId" : "R-XTR-9934501",
    "displayName" : "Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116217 ],
    "parents" : [ ],
    "children" : [ 10727334, 10675446 ]
  }, {
    "dbId" : 10727346,
    "stId" : "R-XTR-9934435",
    "displayName" : "Homotypic CDH1 trans-dimer cluster [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116218 ],
    "parents" : [ ],
    "children" : [ 10727344 ]
  }, {
    "dbId" : 10727344,
    "stId" : "R-XTR-9934420",
    "displayName" : "Homotypic CDH1 trans-dimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10727346 ],
    "children" : [ 10727342, 74112 ]
  }, {
    "dbId" : 10731450,
    "stId" : "R-XTR-9764265",
    "displayName" : "Regulation of CDH1 Expression and Function",
    "schemaClass" : "Pathway",
    "speciesId" : 205621,
    "diagramIds" : [ 116233 ]
  }, {
    "dbId" : 10675772,
    "stId" : "R-XTR-451898",
    "displayName" : "JAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7DKS0",
    "standardIdentifier" : "uniprot:F7DKS0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10676098 ],
    "children" : [ ]
  }, {
    "dbId" : 10676098,
    "stId" : "R-XTR-1067656",
    "displayName" : "JAK1, JAK2, (TYK2) [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10676104 ],
    "children" : [ 10675772, 10676096, 10675829 ]
  }, {
    "dbId" : 10676096,
    "stId" : "R-XTR-210620",
    "displayName" : "JAK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0JM01",
    "standardIdentifier" : "uniprot:A0JM01",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10676098 ],
    "children" : [ ]
  }, {
    "dbId" : 10676102,
    "stId" : "R-XTR-448453",
    "displayName" : "il6st [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8QKR5",
    "standardIdentifier" : "uniprot:A0A6I8QKR5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "il6st" ],
    "parents" : [ 10676104, 10680718 ],
    "children" : [ ]
  }, {
    "dbId" : 10680711,
    "stId" : "R-XTR-1112543",
    "displayName" : "phospho-p-Y1034-JAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7DKS0",
    "standardIdentifier" : "uniprot:F7DKS0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10680716 ],
    "children" : [ ]
  }, {
    "dbId" : 10672900,
    "stId" : "R-XTR-418996",
    "displayName" : "ctnnd1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7C4Y1",
    "standardIdentifier" : "uniprot:F7C4Y1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ctnnd1" ],
    "parents" : [ 10724981, 10724983 ],
    "children" : [ ]
  }, {
    "dbId" : 10680714,
    "stId" : "R-XTR-1112598",
    "displayName" : "phospho-p-Y1054-TYK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8QQ90",
    "standardIdentifier" : "uniprot:A0A6I8QQ90",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10680716 ],
    "children" : [ ]
  }, {
    "dbId" : 10675466,
    "stId" : "R-XTR-445783",
    "displayName" : "acta2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q5M8T9",
    "standardIdentifier" : "uniprot:Q5M8T9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "acta2" ],
    "parents" : [ 10727326 ],
    "children" : [ ]
  }, {
    "dbId" : 10676104,
    "stId" : "R-XTR-1067690",
    "displayName" : "IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116181 ],
    "parents" : [ 10680680, 10680693 ],
    "children" : [ 10676102, 10676098 ]
  }, {
    "dbId" : 10680718,
    "stId" : "R-XTR-1112556",
    "displayName" : "IL6RB:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10680720, 10680722 ],
    "children" : [ 10680716, 10676102 ]
  }, {
    "dbId" : 10680716,
    "stId" : "R-XTR-1112596",
    "displayName" : "Activated JAK1, JAK2, TYK2 [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10680718, 10680735 ],
    "children" : [ 10679511, 10680711, 10680714 ]
  }, {
    "dbId" : 10680722,
    "stId" : "R-XTR-1112513",
    "displayName" : "IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10680724 ],
    "children" : [ 10680718, 10680676 ]
  }, {
    "dbId" : 10680720,
    "stId" : "R-XTR-1112548",
    "displayName" : "IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10680724 ],
    "children" : [ 10680718, 10680691 ]
  }, {
    "dbId" : 10719633,
    "stId" : "R-XTR-390536",
    "displayName" : "actc1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6P640",
    "standardIdentifier" : "uniprot:Q6P640",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "actc1" ],
    "parents" : [ 10727324 ],
    "children" : [ ]
  }, {
    "dbId" : 10666257,
    "stId" : "R-XTR-201861",
    "displayName" : "actg1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6P378",
    "standardIdentifier" : "uniprot:Q6P378",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "actg1" ],
    "parents" : [ 10727326 ],
    "children" : [ ]
  }, {
    "dbId" : 10680726,
    "stId" : "R-XTR-1112515",
    "displayName" : "IL6 receptor hexamer:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116192 ],
    "parents" : [ ],
    "children" : [ 10680724 ]
  }, {
    "dbId" : 10680724,
    "stId" : "R-XTR-1112579",
    "displayName" : "IL6 receptor trimer:Activated JAKs [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10680726 ],
    "children" : [ 10680720, 10680722 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 116194, 116201, 116207, 116190 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10727328 ],
    "children" : [ ]
  }, {
    "dbId" : 10727322,
    "stId" : "R-XTR-390534",
    "displayName" : "acta1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F6UH63",
    "standardIdentifier" : "uniprot:F6UH63",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "acta1" ],
    "parents" : [ 10727324 ],
    "children" : [ ]
  }, {
    "dbId" : 10719641,
    "stId" : "R-XTR-201598",
    "displayName" : "jup [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6P259",
    "standardIdentifier" : "uniprot:Q6P259",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "jup" ],
    "parents" : [ 10724200 ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 116209, 116195, 116202, 116191 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10680735,
    "stId" : "R-XTR-1112563",
    "displayName" : "Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10680739, 10680737 ],
    "children" : [ 10680733, 10680716 ]
  }, {
    "dbId" : 10727326,
    "stId" : "R-XTR-9913262",
    "displayName" : "(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2)",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10727328 ],
    "children" : [ 10727324, 10675466, 10666257 ]
  }, {
    "dbId" : 10680733,
    "stId" : "R-XTR-1112580",
    "displayName" : "phospho-il6st [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8QKR5",
    "standardIdentifier" : "uniprot:A0A6I8QKR5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "il6st" ],
    "parents" : [ 10680735 ],
    "children" : [ ]
  }, {
    "dbId" : 10727324,
    "stId" : "R-XTR-390535",
    "displayName" : "alpha Actin [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10727326 ],
    "children" : [ 10727322, 10719633 ]
  }, {
    "dbId" : 10680674,
    "stId" : "R-XTR-1067661",
    "displayName" : "il11ra [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 116178 ],
    "identifier" : "F6SCJ4",
    "standardIdentifier" : "uniprot:F6SCJ4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "il11ra" ],
    "parents" : [ 10680676 ],
    "children" : [ ]
  }, {
    "dbId" : 10680672,
    "stId" : "R-XTR-447100",
    "displayName" : "il6 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 116174 ],
    "identifier" : "A0A803JUX3",
    "standardIdentifier" : "uniprot:A0A803JUX3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "il6" ],
    "parents" : [ 10680676, 10680691 ],
    "children" : [ ]
  }, {
    "dbId" : 10724198,
    "stId" : "R-XTR-9933840",
    "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10724975 ],
    "children" : [ 10664412, 10724196 ]
  }, {
    "dbId" : 10680676,
    "stId" : "R-XTR-1067687",
    "displayName" : "IL6:IL6R-2 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116179 ],
    "parents" : [ 10680684, 10680680, 10680722, 10680739 ],
    "children" : [ 10680672, 10680674 ]
  }, {
    "dbId" : 10724196,
    "stId" : "R-XTR-9933842",
    "displayName" : "phospho-cdh3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8SJT4",
    "standardIdentifier" : "uniprot:A0A6I8SJT4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "cdh3" ],
    "parents" : [ 10724200, 10724198 ],
    "children" : [ ]
  }, {
    "dbId" : 10680682,
    "stId" : "R-XTR-1067653",
    "displayName" : "il6st [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8QKR5",
    "standardIdentifier" : "uniprot:A0A6I8QKR5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "il6st" ],
    "parents" : [ 10680684 ],
    "children" : [ ]
  }, {
    "dbId" : 10680680,
    "stId" : "R-XTR-1067691",
    "displayName" : "IL6:sIL6R:IL6RB:JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116184 ],
    "parents" : [ 10680695 ],
    "children" : [ 10676104, 10680676 ]
  }, {
    "dbId" : 10724200,
    "stId" : "R-XTR-9934364",
    "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:JUP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10724977 ],
    "children" : [ 10719641, 10724196 ]
  }, {
    "dbId" : 10724975,
    "stId" : "R-XTR-9934338",
    "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1:CTNNA1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10724983 ],
    "children" : [ 10668872, 10724198 ]
  }, {
    "dbId" : 10680684,
    "stId" : "R-XTR-1067674",
    "displayName" : "IL6:IL6R-2:IL6ST-2 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116185 ],
    "parents" : [ ],
    "children" : [ 10680682, 10680676 ]
  }, {
    "dbId" : 10680691,
    "stId" : "R-XTR-1067638",
    "displayName" : "IL6:IL6R [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116175 ],
    "parents" : [ 10680693, 10680720, 10680737 ],
    "children" : [ 10680689, 10680672 ]
  }, {
    "dbId" : 10724977,
    "stId" : "R-XTR-9934369",
    "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:JUP:CTNNA1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10724981 ],
    "children" : [ 10724200, 10668872 ]
  }, {
    "dbId" : 10680689,
    "stId" : "R-XTR-197824",
    "displayName" : "il11ra [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 116173 ],
    "identifier" : "F6SCJ4",
    "standardIdentifier" : "uniprot:F6SCJ4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "il11ra" ],
    "parents" : [ 10680701, 10680691 ],
    "children" : [ ]
  }, {
    "dbId" : 10724983,
    "stId" : "R-XTR-9934399",
    "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1:CTNNA1:CTNND1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10724985 ],
    "children" : [ 10724975, 10672900 ]
  }, {
    "dbId" : 10675446,
    "stId" : "R-XTR-350753",
    "displayName" : "Ghost homologue of VCL [cytosol]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10727342, 10727338, 10727340 ],
    "children" : [ ]
  }, {
    "dbId" : 10680695,
    "stId" : "R-XTR-1112523",
    "displayName" : "IL6 receptor trimer:JAKs [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 116187 ],
    "parents" : [ 10680697 ],
    "children" : [ 10680680, 10680693 ]
  }, {
    "dbId" : 10728182,
    "stId" : "R-XTR-9958926",
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116199 ],
    "parents" : [ ],
    "children" : [ 10670922, 10680743 ]
  }, {
    "dbId" : 10724981,
    "stId" : "R-XTR-9934397",
    "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:JUP:CTNNA1:CTNND1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10724985 ],
    "children" : [ 10672900, 10724977 ]
  }, {
    "dbId" : 10675829,
    "stId" : "R-XTR-877348",
    "displayName" : "TYK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8QQ90",
    "standardIdentifier" : "uniprot:A0A6I8QQ90",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10676098 ],
    "children" : [ ]
  }, {
    "dbId" : 10680693,
    "stId" : "R-XTR-1067654",
    "displayName" : "IL6:IL6RA:IL6RB:JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116182 ],
    "parents" : [ 10680695 ],
    "children" : [ 10676104, 10680691 ]
  }, {
    "dbId" : 10724985,
    "stId" : "R-XTR-9934398",
    "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 116208 ],
    "parents" : [ 10727342, 10727338, 10727332 ],
    "children" : [ 10724981, 10724983 ]
  }, {
    "dbId" : 10680697,
    "stId" : "R-XTR-1112588",
    "displayName" : "IL6 receptor hexamer:JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116188 ],
    "parents" : [ ],
    "children" : [ 10680695 ]
  }, {
    "dbId" : 10728184,
    "stId" : "R-XTR-9958930",
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:p-Y705-STAT3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116203 ],
    "parents" : [ ],
    "children" : [ 10680750, 10680743 ]
  }, {
    "dbId" : 10680701,
    "stId" : "R-XTR-9681293",
    "displayName" : "IL6R:IL6R inhibitors [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116176 ],
    "parents" : [ ],
    "children" : [ 9715042, 10680689 ]
  }, {
    "dbId" : 10730054,
    "stId" : "R-XTR-6783589",
    "displayName" : "Interleukin-6 family signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 205621,
    "diagramIds" : [ 116250 ]
  }, {
    "dbId" : 10727371,
    "stId" : "R-XTR-9934835",
    "displayName" : "phospho-ctnnd1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7C4Y1",
    "standardIdentifier" : "uniprot:F7C4Y1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ctnnd1" ],
    "parents" : [ 10727377 ],
    "children" : [ ]
  }, {
    "dbId" : 10670922,
    "stId" : "R-XTR-539044",
    "displayName" : "stat3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 116198 ],
    "identifier" : "A0A803J6M0",
    "standardIdentifier" : "uniprot:A0A803J6M0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "stat3" ],
    "parents" : [ 10728182 ],
    "children" : [ ]
  }, {
    "dbId" : 10668872,
    "stId" : "R-XTR-191697",
    "displayName" : "ctnna1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 116210 ],
    "identifier" : "F7DHT4",
    "standardIdentifier" : "uniprot:F7DHT4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ctnna1" ],
    "parents" : [ 10724977, 10724975 ],
    "children" : [ ]
  }, {
    "dbId" : 9715070,
    "stId" : "R-ALL-9715070",
    "displayName" : "satralizumab [extracellular region]",
    "schemaClass" : "ProteinDrug",
    "speciesId" : 0,
    "identifier" : "9093",
    "standardIdentifier" : "iuphar.ligand:9093",
    "parents" : [ 9715042 ],
    "children" : [ ]
  }, {
    "dbId" : 10727375,
    "stId" : "R-XTR-9934836",
    "displayName" : "phospho-cdh3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8SJT4",
    "standardIdentifier" : "uniprot:A0A6I8SJT4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "cdh3" ],
    "parents" : [ 10727377 ],
    "children" : [ ]
  }, {
    "dbId" : 10727377,
    "stId" : "R-XTR-9934823",
    "displayName" : "Man,Man9GlucNAc2,p-3S,2Y-CDH1:p-Y-CTNND1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 116211 ],
    "parents" : [ ],
    "children" : [ 10727375, 10727371 ]
  }, {
    "dbId" : 10727383,
    "stId" : "R-XTR-9934829",
    "displayName" : "phospho-jup [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6P259",
    "standardIdentifier" : "uniprot:Q6P259",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "jup" ],
    "parents" : [ 10727385 ],
    "children" : [ ]
  }, {
    "dbId" : 10679511,
    "stId" : "R-XTR-873799",
    "displayName" : "phospho-p-Y1007-JAK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0JM01",
    "standardIdentifier" : "uniprot:A0JM01",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10680716 ],
    "children" : [ ]
  }, {
    "dbId" : 9715042,
    "stId" : "R-ALL-9715042",
    "displayName" : "IL6R inhibitors [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "parents" : [ 10680701 ],
    "children" : [ 9715049, 9715070, 9681301 ]
  }, {
    "dbId" : 10727380,
    "stId" : "R-XTR-8876940",
    "displayName" : "phospho-ctnnb1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28GC2",
    "standardIdentifier" : "uniprot:Q28GC2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ctnnb1" ],
    "parents" : [ 10727385 ],
    "children" : [ ]
  }, {
    "dbId" : 10727385,
    "stId" : "R-XTR-9935537",
    "displayName" : "p-Y-CTNNB1,p-Y-JUP [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 116212 ],
    "parents" : [ ],
    "children" : [ 10727380, 10727383 ]
  }, {
    "dbId" : 9715049,
    "stId" : "R-ALL-9715049",
    "displayName" : "sarilumab [extracellular region]",
    "schemaClass" : "ProteinDrug",
    "speciesId" : 0,
    "identifier" : "7999",
    "standardIdentifier" : "iuphar.ligand:7999",
    "parents" : [ 9715042 ],
    "children" : [ ]
  }, {
    "dbId" : 10664412,
    "stId" : "R-XTR-448839",
    "displayName" : "ctnnb1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28GC2",
    "standardIdentifier" : "uniprot:Q28GC2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ctnnb1" ],
    "parents" : [ 10724198 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10728194,
    "stId" : "R-XTR-9958889",
    "displayName" : "SRC phosphorylates CDH1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10724985, 113592 ],
    "outputs" : [ 10727385, 10668872, 29370, 10727377 ],
    "catalysts" : [ 10669230 ],
    "efs" : [ ],
    "diagramIds" : [ 116206 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10680678,
    "stId" : "R-XTR-1067640",
    "displayName" : "IL6 binds IL6R-2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10680686 ],
    "inputs" : [ 10680672, 10680674 ],
    "outputs" : [ 10680676 ],
    "efs" : [ ],
    "diagramIds" : [ 116177 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10680708,
    "stId" : "R-XTR-1067688",
    "displayName" : "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10680703 ],
    "following" : [ 10680699 ],
    "inputs" : [ 10676104, 10680691 ],
    "outputs" : [ 10680693 ],
    "efs" : [ ],
    "diagramIds" : [ 116180 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10680747,
    "stId" : "R-XTR-1112514",
    "displayName" : "JAK activation",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10680699 ],
    "following" : [ 10680745 ],
    "inputs" : [ 10680697, 113592 ],
    "outputs" : [ 29370, 10680726 ],
    "efs" : [ ],
    "diagramIds" : [ 116189 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10680745,
    "stId" : "R-XTR-1112510",
    "displayName" : "IL6ST is tyrosine phosphorylated",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10680747 ],
    "following" : [ 10728191 ],
    "inputs" : [ 113592, 10680726 ],
    "outputs" : [ 29370, 10680743 ],
    "efs" : [ ],
    "diagramIds" : [ 116193 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10680686,
    "stId" : "R-XTR-1067651",
    "displayName" : "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10680678 ],
    "following" : [ 10680699 ],
    "inputs" : [ 10676104, 10680676 ],
    "outputs" : [ 10680680 ],
    "efs" : [ ],
    "inhibitors" : [ 10680684 ],
    "diagramIds" : [ 116183 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10727350,
    "stId" : "R-XTR-9934411",
    "displayName" : "CDH1 forms cis-clusters",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10727352 ],
    "inputs" : [ 10724985 ],
    "outputs" : [ 10727332 ],
    "efs" : [ ],
    "diagramIds" : [ 116219 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10727348,
    "stId" : "R-XTR-9934410",
    "displayName" : "CDH1 forms homotypic trans-dimers",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10727352 ],
    "inputs" : [ 10727340, 10727338, 74112 ],
    "outputs" : [ 10727346 ],
    "efs" : [ ],
    "diagramIds" : [ 116214 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10728187,
    "stId" : "R-XTR-9958871",
    "displayName" : "Tyrosine phosphorylation of STAT3 by IL6 receptor",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10728191 ],
    "following" : [ 10728189 ],
    "inputs" : [ 113592, 10728182 ],
    "outputs" : [ 10728184, 29370 ],
    "catalysts" : [ 10728182 ],
    "efs" : [ ],
    "diagramIds" : [ 116200 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10680699,
    "stId" : "R-XTR-1067659",
    "displayName" : "Assembly of hexameric IL-6 receptor",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10680686, 10680708 ],
    "following" : [ 10680747 ],
    "inputs" : [ 10680695 ],
    "outputs" : [ 10680697 ],
    "efs" : [ ],
    "diagramIds" : [ 116186 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10727352,
    "stId" : "R-XTR-9934486",
    "displayName" : "CDH1-associated CTNNA1 binds F-actin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10727350 ],
    "following" : [ 10727348 ],
    "inputs" : [ 10727332, 10727330 ],
    "outputs" : [ 10727334 ],
    "efs" : [ ],
    "diagramIds" : [ 116221 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10728191,
    "stId" : "R-XTR-9958878",
    "displayName" : "Tyrosine phosphorylated IL6ST binds STAT3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10680745 ],
    "following" : [ 10728187 ],
    "inputs" : [ 10670922, 10680743 ],
    "outputs" : [ 10728182 ],
    "efs" : [ ],
    "diagramIds" : [ 116197 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10680703,
    "stId" : "R-XTR-1067667",
    "displayName" : "IL6 binds IL6R",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10680708 ],
    "inputs" : [ 10680689, 10680672 ],
    "outputs" : [ 10680691 ],
    "efs" : [ ],
    "inhibitors" : [ 10680701 ],
    "diagramIds" : [ 116172 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10728189,
    "stId" : "R-XTR-9958877",
    "displayName" : "p-Y705-STAT3 dissociates from IL6 receptor",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10728187 ],
    "inputs" : [ 10728184 ],
    "outputs" : [ 10680750, 10680743 ],
    "efs" : [ ],
    "diagramIds" : [ 116204 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10731584,
    "stId" : "R-XTR-9958810",
    "displayName" : "SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)",
    "events" : [ 10728194 ]
  } ]
}