{ "dbId" : 10730032, "stableId" : "R-XTR-5632684", "displayName" : "Hedgehog 'on' state", "nodes" : [ { "id" : 38144, "reactomeId" : 10698660, "displayName" : "GLI:SUFU", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1138, "y" : 334 }, "minX" : 1106, "maxX" : 1176, "minY" : 317, "maxY" : 345, "prop" : { "x" : 1106, "y" : 323, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 1106, "y" : 324 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1170, "y" : 323 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1170, "y" : 323 } } }, "connectors" : [ { "edgeId" : 38143, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38145, "reactomeId" : 10698656, "displayName" : "GLI1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1175, "y" : 211 }, "minX" : 1138, "maxX" : 1253, "minY" : 199, "maxY" : 269, "prop" : { "x" : 1138, "y" : 199, "width" : 74, "height" : 25 }, "textPosition" : { "x" : 1146, "y" : 201 }, "connectors" : [ { "edgeId" : 38157, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1218, "y" : 210 }, "to" : { "x" : 1253, "y" : 209 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38143, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1167, "y" : 230 }, "to" : { "x" : 1139, "y" : 269 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1166, "y" : 238 }, "b" : { "x" : 1167, "y" : 230 }, "c" : { "x" : 1160, "y" : 233 }, "type" : "ARROW", "centre" : { "x" : 1160, "y" : 233 } } } ] }, { "id" : 38146, "reactomeId" : 10698658, "displayName" : "sufu", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1100, "y" : 222 }, "minX" : 1075, "maxX" : 1139, "minY" : 125, "maxY" : 269, "prop" : { "x" : 1079, "y" : 211, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 1082, "y" : 211 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1121, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1121, "y" : 211 } } }, "connectors" : [ { "edgeId" : 38154, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1097, "y" : 208 }, "to" : { "x" : 1075, "y" : 125 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1091, "y" : 202 }, "b" : { "x" : 1097, "y" : 208 }, "c" : { "x" : 1099, "y" : 200 }, "type" : "ARROW", "centre" : { "x" : 1099, "y" : 200 } } }, { "edgeId" : 38143, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1109, "y" : 236 }, "to" : { "x" : 1139, "y" : 269 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1117, "y" : 238 }, "b" : { "x" : 1109, "y" : 236 }, "c" : { "x" : 1111, "y" : 244 }, "type" : "ARROW", "centre" : { "x" : 1111, "y" : 244 } } } ] }, { "id" : 38147, "reactomeId" : 10700045, "displayName" : "p6S, T-SMO dimer:EVC2:EVC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 628, "y" : 223 }, "minX" : 568, "maxX" : 1130, "minY" : 199, "maxY" : 297, "prop" : { "x" : 568, "y" : 205, "width" : 121, "height" : 36 }, "textPosition" : { "x" : 568, "y" : 206 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 689, "y" : 205 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 689, "y" : 205 } } }, "connectors" : [ { "edgeId" : 38143, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 692, "y" : 231 }, "to" : { "x" : 1130, "y" : 294 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1123, "y" : 297 }, "b" : { "x" : 1130, "y" : 294 }, "c" : { "x" : 1124, "y" : 289 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1124, "y" : 289 } } } ] }, { "id" : 38149, "reactomeId" : 10699995, "displayName" : "p-GLI1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1295, "y" : 333 }, "minX" : 1235, "maxX" : 1355, "minY" : 240, "maxY" : 351, "prop" : { "x" : 1235, "y" : 315, "width" : 120, "height" : 36 }, "textPosition" : { "x" : 1260, "y" : 322 }, "connectors" : [ { "edgeId" : 38148, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38157, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1294, "y" : 309 }, "to" : { "x" : 1291, "y" : 240 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1290, "y" : 302 }, "b" : { "x" : 1294, "y" : 309 }, "c" : { "x" : 1298, "y" : 302 }, "type" : "ARROW", "centre" : { "x" : 1298, "y" : 302 } } } ] }, { "id" : 38150, "reactomeId" : 10699979, "displayName" : "p-GLI1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1385, "y" : 1272 }, "minX" : 1342, "maxX" : 1428, "minY" : 1258, "maxY" : 1286, "prop" : { "x" : 1342, "y" : 1258, "width" : 86, "height" : 28 }, "textPosition" : { "x" : 1350, "y" : 1261 }, "connectors" : [ { "edgeId" : 38148, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38152, "reactomeId" : 10700061, "displayName" : "ub-PTCH1:SMURF", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 420, "y" : 877 }, "minX" : 378, "maxX" : 469, "minY" : 853, "maxY" : 896, "prop" : { "x" : 378, "y" : 859, "width" : 85, "height" : 37 }, "textPosition" : { "x" : 384, "y" : 861 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 463, "y" : 859 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 463, "y" : 859 } } }, "connectors" : [ { "edgeId" : 38151, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38153, "reactomeId" : 10665447, "displayName" : "SMURF", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 186, "y" : 1060 }, "minX" : 161, "maxX" : 411, "minY" : 933, "maxY" : 1139, "prop" : { "x" : 161, "y" : 1049, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 161, "y" : 1049 }, "connectors" : [ { "edgeId" : 38151, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 202, "y" : 1077 }, "to" : { "x" : 305, "y" : 1139 } }, { "from" : { "x" : 305, "y" : 1139 }, "to" : { "x" : 379, "y" : 961 } }, { "from" : { "x" : 379, "y" : 961 }, "to" : { "x" : 411, "y" : 933 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 210, "y" : 1077 }, "b" : { "x" : 202, "y" : 1077 }, "c" : { "x" : 206, "y" : 1084 }, "type" : "ARROW", "centre" : { "x" : 206, "y" : 1084 } } } ] }, { "id" : 38155, "reactomeId" : 10699966, "displayName" : "ULK3:SUFU", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 974, "y" : 73 }, "minX" : 921, "maxX" : 1033, "minY" : 49, "maxY" : 92, "prop" : { "x" : 921, "y" : 55, "width" : 106, "height" : 37 }, "textPosition" : { "x" : 936, "y" : 71 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1027, "y" : 55 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1027, "y" : 55 } } }, "connectors" : [ { "edgeId" : 38154, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38156, "reactomeId" : 10699964, "displayName" : "ULK3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1263, "y" : 99 }, "minX" : 1075, "maxX" : 1289, "minY" : 82, "maxY" : 206, "prop" : { "x" : 1243, "y" : 88, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 1244, "y" : 88 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1283, "y" : 88 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1283, "y" : 88 } } }, "connectors" : [ { "edgeId" : 38154, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1240, "y" : 101 }, "to" : { "x" : 1075, "y" : 125 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1234, "y" : 106 }, "b" : { "x" : 1240, "y" : 101 }, "c" : { "x" : 1233, "y" : 98 }, "type" : "ARROW", "centre" : { "x" : 1233, "y" : 98 } } }, { "edgeId" : 38157, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1265, "y" : 113 }, "to" : { "x" : 1284, "y" : 198 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1284, "y" : 202 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1284, "y" : 202 } } } ] }, { "id" : 38158, "reactomeId" : 5632460, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1220, "y" : 168 }, "minX" : 1200, "maxX" : 1253, "minY" : 152, "maxY" : 209, "prop" : { "x" : 1200, "y" : 153, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1204, "y" : 157 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1235, "y" : 158 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1235, "y" : 158 } } }, "connectors" : [ { "edgeId" : 38157, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1232, "y" : 186 }, "to" : { "x" : 1253, "y" : 209 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38159, "reactomeId" : 5632457, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1238, "y" : 282 }, "minX" : 1217, "maxX" : 1291, "minY" : 240, "maxY" : 297, "prop" : { "x" : 1217, "y" : 267, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1221, "y" : 271 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1254, "y" : 272 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1254, "y" : 272 } } }, "connectors" : [ { "edgeId" : 38157, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1256, "y" : 264 }, "to" : { "x" : 1291, "y" : 240 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1259, "y" : 257 }, "b" : { "x" : 1256, "y" : 264 }, "c" : { "x" : 1264, "y" : 263 }, "type" : "ARROW", "centre" : { "x" : 1264, "y" : 263 } } } ] }, { "id" : 38161, "reactomeId" : 10698484, "displayName" : "gpr161", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 491, "y" : 935 }, "minX" : 454, "maxX" : 535, "minY" : 916, "maxY" : 949, "prop" : { "x" : 454, "y" : 922, "width" : 75, "height" : 27 }, "textPosition" : { "x" : 465, "y" : 925 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 529, "y" : 922 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 529, "y" : 922 } } }, "connectors" : [ { "edgeId" : 38160, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38162, "reactomeId" : 10699958, "displayName" : "gpr161", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 497, "y" : 1288 }, "minX" : 463, "maxX" : 538, "minY" : 1261, "maxY" : 1309, "prop" : { "x" : 463, "y" : 1267, "width" : 69, "height" : 42 }, "textPosition" : { "x" : 471, "y" : 1277 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 532, "y" : 1267 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 532, "y" : 1267 } } }, "connectors" : [ { "edgeId" : 38160, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38164, "reactomeId" : 10658025, "displayName" : "cdc73", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1572, "y" : 1155 }, "minX" : 1543, "maxX" : 1656, "minY" : 1138, "maxY" : 1166, "prop" : { "x" : 1543, "y" : 1144, "width" : 59, "height" : 22 }, "textPosition" : { "x" : 1549, "y" : 1144 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1602, "y" : 1144 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1602, "y" : 1144 } } }, "connectors" : [ { "edgeId" : 38163, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1605, "y" : 1154 }, "to" : { "x" : 1656, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38165, "reactomeId" : 10699987, "displayName" : "2p-GLI1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1594, "y" : 1268 }, "minX" : 1538, "maxX" : 1656, "minY" : 1154, "maxY" : 1285, "prop" : { "x" : 1538, "y" : 1252, "width" : 113, "height" : 33 }, "textPosition" : { "x" : 1555, "y" : 1258 }, "connectors" : [ { "edgeId" : 38163, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1602, "y" : 1246 }, "to" : { "x" : 1656, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38166, "reactomeId" : 10700002, "displayName" : "CDC73:2p-GLI", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1784, "y" : 1154 }, "minX" : 1747, "maxX" : 1827, "minY" : 1127, "maxY" : 1175, "prop" : { "x" : 1747, "y" : 1133, "width" : 74, "height" : 42 }, "textPosition" : { "x" : 1747, "y" : 1140 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1821, "y" : 1133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1821, "y" : 1133 } } }, "connectors" : [ { "edgeId" : 38163, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38168, "reactomeId" : 10700030, "displayName" : "SPOP:CUL3:RBX1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1388, "y" : 1721 }, "minX" : 1332, "maxX" : 1883, "minY" : 1704, "maxY" : 1831, "prop" : { "x" : 1332, "y" : 1710, "width" : 112, "height" : 22 }, "textPosition" : { "x" : 1332, "y" : 1711 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1444, "y" : 1710 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1444, "y" : 1710 } } }, "connectors" : [ { "edgeId" : 38167, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1447, "y" : 1717 }, "to" : { "x" : 1482, "y" : 1715 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38174, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1390, "y" : 1735 }, "to" : { "x" : 1412, "y" : 1831 } }, { "from" : { "x" : 1412, "y" : 1831 }, "to" : { "x" : 1883, "y" : 1826 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1395, "y" : 1741 }, "b" : { "x" : 1390, "y" : 1735 }, "c" : { "x" : 1388, "y" : 1743 }, "type" : "ARROW", "centre" : { "x" : 1388, "y" : 1743 } } } ] }, { "id" : 38169, "reactomeId" : 10700036, "displayName" : "2p-GLI2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1369, "y" : 1512 }, "minX" : 1335, "maxX" : 1482, "minY" : 1501, "maxY" : 1715, "prop" : { "x" : 1335, "y" : 1501, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 1336, "y" : 1501 }, "connectors" : [ { "edgeId" : 38167, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1375, "y" : 1529 }, "to" : { "x" : 1482, "y" : 1715 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38170, "reactomeId" : 10700038, "displayName" : "2p-GLI:SPOP:CUL3:RBX1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1586, "y" : 1715 }, "minX" : 1545, "maxX" : 1692, "minY" : 1685, "maxY" : 1740, "prop" : { "x" : 1545, "y" : 1691, "width" : 83, "height" : 49 }, "textPosition" : { "x" : 1546, "y" : 1691 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1628, "y" : 1691 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1628, "y" : 1691 } } }, "connectors" : [ { "edgeId" : 38167, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38171, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1631, "y" : 1715 }, "to" : { "x" : 1670, "y" : 1715 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38171, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1631, "y" : 1699 }, "to" : { "x" : 1663, "y" : 1686 } }, { "from" : { "x" : 1663, "y" : 1686 }, "to" : { "x" : 1685, "y" : 1704 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1688, "y" : 1706 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1688, "y" : 1706 } } } ] }, { "id" : 38172, "reactomeId" : 10651555, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1652, "y" : 1768 }, "minX" : 1621, "maxX" : 1883, "minY" : 1715, "maxY" : 1826, "prop" : { "x" : 1621, "y" : 1757, "width" : 62, "height" : 22 }, "textPosition" : { "x" : 1639, "y" : 1757 }, "connectors" : [ { "edgeId" : 38171, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1655, "y" : 1751 }, "to" : { "x" : 1670, "y" : 1715 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38174, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1689, "y" : 1775 }, "to" : { "x" : 1883, "y" : 1826 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1697, "y" : 1773 }, "b" : { "x" : 1689, "y" : 1775 }, "c" : { "x" : 1695, "y" : 1781 }, "type" : "ARROW", "centre" : { "x" : 1695, "y" : 1781 } } } ] }, { "id" : 38173, "reactomeId" : 10700032, "displayName" : "ub-2p-GLI2,3:SPOP:CUL3:RBX1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1788, "y" : 1714 }, "minX" : 1729, "maxX" : 1854, "minY" : 1683, "maxY" : 1739, "prop" : { "x" : 1729, "y" : 1689, "width" : 119, "height" : 50 }, "textPosition" : { "x" : 1733, "y" : 1704 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1848, "y" : 1689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1848, "y" : 1689 } } }, "connectors" : [ { "edgeId" : 38171, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38174, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38175, "reactomeId" : 10651772, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1931, "y" : 1681 }, "minX" : 1875, "maxX" : 1994, "minY" : 1664, "maxY" : 1715, "prop" : { "x" : 1875, "y" : 1670, "width" : 113, "height" : 22 }, "textPosition" : { "x" : 1875, "y" : 1671 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1988, "y" : 1670 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1988, "y" : 1670 } } }, "connectors" : [ { "edgeId" : 38174, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1916, "y" : 1695 }, "to" : { "x" : 1894, "y" : 1709 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1891, "y" : 1711 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1891, "y" : 1711 } } } ] }, { "id" : 38177, "reactomeId" : 10698571, "displayName" : "numb", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2239, "y" : 1205 }, "minX" : 2214, "maxX" : 2268, "minY" : 1188, "maxY" : 1237, "prop" : { "x" : 2217, "y" : 1194, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 2218, "y" : 1194 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2262, "y" : 1194 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2262, "y" : 1194 } } }, "connectors" : [ { "edgeId" : 38176, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2230, "y" : 1219 }, "to" : { "x" : 2214, "y" : 1237 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38178, "reactomeId" : 10677509, "displayName" : "itch", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2165, "y" : 1207 }, "minX" : 2138, "maxX" : 2214, "minY" : 1190, "maxY" : 1237, "prop" : { "x" : 2138, "y" : 1196, "width" : 54, "height" : 22 }, "textPosition" : { "x" : 2149, "y" : 1196 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2192, "y" : 1196 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2192, "y" : 1196 } } }, "connectors" : [ { "edgeId" : 38176, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2182, "y" : 1221 }, "to" : { "x" : 2214, "y" : 1237 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38179, "reactomeId" : 10698573, "displayName" : "NUMB:ITCH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2223, "y" : 1310 }, "minX" : 2185, "maxX" : 2413, "minY" : 1267, "maxY" : 1393, "prop" : { "x" : 2185, "y" : 1299, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 2185, "y" : 1300 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2261, "y" : 1299 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2261, "y" : 1299 } } }, "connectors" : [ { "edgeId" : 38176, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38180, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2223, "y" : 1324 }, "to" : { "x" : 2230, "y" : 1393 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38186, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2264, "y" : 1301 }, "to" : { "x" : 2413, "y" : 1267 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2270, "y" : 1296 }, "b" : { "x" : 2264, "y" : 1301 }, "c" : { "x" : 2272, "y" : 1303 }, "type" : "ARROW", "centre" : { "x" : 2272, "y" : 1303 } } } ] }, { "id" : 38181, "reactomeId" : 10698466, "displayName" : "gli1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2159, "y" : 1393 }, "minX" : 2123, "maxX" : 2230, "minY" : 1372, "maxY" : 1408, "prop" : { "x" : 2123, "y" : 1378, "width" : 72, "height" : 30 }, "textPosition" : { "x" : 2144, "y" : 1382 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2195, "y" : 1378 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2195, "y" : 1378 } } }, "connectors" : [ { "edgeId" : 38180, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2198, "y" : 1393 }, "to" : { "x" : 2230, "y" : 1393 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38182, "reactomeId" : 10700050, "displayName" : "GLI1:NUMB:ITCH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2337, "y" : 1398 }, "minX" : 2296, "maxX" : 2413, "minY" : 1376, "maxY" : 1439, "prop" : { "x" : 2296, "y" : 1382, "width" : 83, "height" : 33 }, "textPosition" : { "x" : 2298, "y" : 1380 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2379, "y" : 1382 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2379, "y" : 1382 } } }, "connectors" : [ { "edgeId" : 38180, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2382, "y" : 1399 }, "to" : { "x" : 2398, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38183, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2353, "y" : 1418 }, "to" : { "x" : 2377, "y" : 1439 } }, { "from" : { "x" : 2377, "y" : 1439 }, "to" : { "x" : 2406, "y" : 1411 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2409, "y" : 1408 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2409, "y" : 1408 } } } ] }, { "id" : 38184, "reactomeId" : 10651914, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2363, "y" : 1336 }, "minX" : 2330, "maxX" : 2413, "minY" : 1267, "maxY" : 1400, "prop" : { "x" : 2330, "y" : 1319, "width" : 67, "height" : 34 }, "textPosition" : { "x" : 2351, "y" : 1325 }, "connectors" : [ { "edgeId" : 38183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2372, "y" : 1359 }, "to" : { "x" : 2398, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38186, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2375, "y" : 1313 }, "to" : { "x" : 2413, "y" : 1267 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2376, "y" : 1305 }, "b" : { "x" : 2375, "y" : 1313 }, "c" : { "x" : 2382, "y" : 1310 }, "type" : "ARROW", "centre" : { "x" : 2382, "y" : 1310 } } } ] }, { "id" : 38185, "reactomeId" : 10700056, "displayName" : "ub-GLI1:NUMB:ITCH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2493, "y" : 1396 }, "minX" : 2446, "maxX" : 2547, "minY" : 1368, "maxY" : 1419, "prop" : { "x" : 2446, "y" : 1374, "width" : 95, "height" : 45 }, "textPosition" : { "x" : 2456, "y" : 1384 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2541, "y" : 1374 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2541, "y" : 1374 } } }, "connectors" : [ { "edgeId" : 38183, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38186, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38187, "reactomeId" : 10652008, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2491, "y" : 1224 }, "minX" : 2447, "maxX" : 2542, "minY" : 1201, "maxY" : 1273, "prop" : { "x" : 2447, "y" : 1207, "width" : 89, "height" : 35 }, "textPosition" : { "x" : 2449, "y" : 1207 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2536, "y" : 1207 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2536, "y" : 1207 } } }, "connectors" : [ { "edgeId" : 38186, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2492, "y" : 1245 }, "to" : { "x" : 2494, "y" : 1265 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2494, "y" : 1269 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2494, "y" : 1269 } } } ] }, { "id" : 38201, "reactomeId" : 10699981, "displayName" : "phospho-gli1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1493, "y" : 1534 }, "minX" : 1462, "maxX" : 1531, "minY" : 1512, "maxY" : 1551, "prop" : { "x" : 1462, "y" : 1518, "width" : 63, "height" : 33 }, "textPosition" : { "x" : 1462, "y" : 1517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1525, "y" : 1518 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1525, "y" : 1518 } } }, "connectors" : [ ] }, { "id" : 38117, "reactomeId" : 10668855, "displayName" : "cdon", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 421, "y" : 600 }, "minX" : 334, "maxX" : 454, "minY" : 574, "maxY" : 612, "prop" : { "x" : 394, "y" : 589, "width" : 54, "height" : 23 }, "textPosition" : { "x" : 401, "y" : 590 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 448, "y" : 589 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 448, "y" : 589 } } }, "connectors" : [ { "edgeId" : 38116, "type" : "INPUT", "segments" : [ { "from" : { "x" : 391, "y" : 591 }, "to" : { "x" : 334, "y" : 574 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38118, "reactomeId" : 10675379, "displayName" : "Hh-Npp", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 30, "y" : 621 }, "minX" : 0, "maxX" : 334, "minY" : 107, "maxY" : 632, "prop" : { "x" : 0, "y" : 610, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 3, "y" : 610 }, "connectors" : [ { "edgeId" : 38116, "type" : "INPUT", "segments" : [ { "from" : { "x" : 67, "y" : 616 }, "to" : { "x" : 334, "y" : 574 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38121, "type" : "INPUT", "segments" : [ { "from" : { "x" : 44, "y" : 604 }, "to" : { "x" : 309, "y" : 404 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38136, "type" : "INPUT", "segments" : [ { "from" : { "x" : 35, "y" : 604 }, "to" : { "x" : 291, "y" : 107 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38119, "reactomeId" : 10698645, "displayName" : "ptch1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 407, "y" : 650 }, "minX" : 284, "maxX" : 450, "minY" : 404, "maxY" : 664, "prop" : { "x" : 370, "y" : 637, "width" : 74, "height" : 27 }, "textPosition" : { "x" : 385, "y" : 640 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 444, "y" : 637 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 444, "y" : 637 } } }, "connectors" : [ { "edgeId" : 38116, "type" : "INPUT", "segments" : [ { "from" : { "x" : 394, "y" : 634 }, "to" : { "x" : 334, "y" : 574 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38121, "type" : "INPUT", "segments" : [ { "from" : { "x" : 384, "y" : 634 }, "to" : { "x" : 284, "y" : 575 } }, { "from" : { "x" : 284, "y" : 575 }, "to" : { "x" : 309, "y" : 404 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38120, "reactomeId" : 10699873, "displayName" : "Hh-Npp:CDON:PTCH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 430, "y" : 523 }, "minX" : 388, "maxX" : 478, "minY" : 499, "maxY" : 542, "prop" : { "x" : 388, "y" : 505, "width" : 84, "height" : 37 }, "textPosition" : { "x" : 390, "y" : 507 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 472, "y" : 505 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 472, "y" : 505 } } }, "connectors" : [ { "edgeId" : 38116, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38122, "reactomeId" : 10699867, "displayName" : "gas1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 414, "y" : 456 }, "minX" : 309, "maxX" : 449, "minY" : 404, "maxY" : 472, "prop" : { "x" : 385, "y" : 440, "width" : 58, "height" : 32 }, "textPosition" : { "x" : 394, "y" : 445 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 443, "y" : 440 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 443, "y" : 440 } } }, "connectors" : [ { "edgeId" : 38121, "type" : "INPUT", "segments" : [ { "from" : { "x" : 382, "y" : 441 }, "to" : { "x" : 309, "y" : 404 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38123, "reactomeId" : 10699869, "displayName" : "Hh-Npp:GAS1:PTCH", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 414, "y" : 377 }, "minX" : 371, "maxX" : 463, "minY" : 349, "maxY" : 400, "prop" : { "x" : 371, "y" : 355, "width" : 86, "height" : 45 }, "textPosition" : { "x" : 375, "y" : 365 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 457, "y" : 355 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 457, "y" : 355 } } }, "connectors" : [ { "edgeId" : 38121, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38125, "reactomeId" : 10699880, "displayName" : "ptch1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 417, "y" : 988 }, "minX" : 387, "maxX" : 453, "minY" : 933, "maxY" : 1005, "prop" : { "x" : 387, "y" : 971, "width" : 60, "height" : 34 }, "textPosition" : { "x" : 395, "y" : 977 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 447, "y" : 971 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 447, "y" : 971 } } }, "connectors" : [ { "edgeId" : 38151, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 415, "y" : 968 }, "to" : { "x" : 411, "y" : 933 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 410, "y" : 962 }, "b" : { "x" : 415, "y" : 968 }, "c" : { "x" : 418, "y" : 961 }, "type" : "ARROW", "centre" : { "x" : 418, "y" : 961 } } }, { "edgeId" : 38124, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38126, "reactomeId" : 10699882, "displayName" : "ptch1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 433, "y" : 1332 }, "minX" : 401, "maxX" : 472, "minY" : 1307, "maxY" : 1352, "prop" : { "x" : 401, "y" : 1313, "width" : 65, "height" : 39 }, "textPosition" : { "x" : 411, "y" : 1322 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 466, "y" : 1313 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 466, "y" : 1313 } } }, "connectors" : [ { "edgeId" : 38124, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38128, "reactomeId" : 10699926, "displayName" : "EFCAB7:IQCE", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 652, "y" : 83 }, "minX" : 608, "maxX" : 702, "minY" : 66, "maxY" : 150, "prop" : { "x" : 608, "y" : 72, "width" : 88, "height" : 22 }, "textPosition" : { "x" : 608, "y" : 73 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 696, "y" : 72 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 696, "y" : 72 } } }, "connectors" : [ { "edgeId" : 38127, "type" : "INPUT", "segments" : [ { "from" : { "x" : 657, "y" : 97 }, "to" : { "x" : 683, "y" : 150 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38129, "reactomeId" : 10699936, "displayName" : "EVC2:EVC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 596, "y" : 150 }, "minX" : 561, "maxX" : 683, "minY" : 133, "maxY" : 161, "prop" : { "x" : 561, "y" : 139, "width" : 70, "height" : 22 }, "textPosition" : { "x" : 562, "y" : 140 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 631, "y" : 139 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 631, "y" : 139 } } }, "connectors" : [ { "edgeId" : 38127, "type" : "INPUT", "segments" : [ { "from" : { "x" : 634, "y" : 150 }, "to" : { "x" : 683, "y" : 150 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38130, "reactomeId" : 10699938, "displayName" : "IQCE:EFCAB7:EVC2:EVC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 738, "y" : 24 }, "minX" : 687, "maxX" : 795, "minY" : 0, "maxY" : 42, "prop" : { "x" : 687, "y" : 6, "width" : 102, "height" : 36 }, "textPosition" : { "x" : 692, "y" : 7 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 789, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 789, "y" : 6 } } }, "connectors" : [ { "edgeId" : 38127, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38132, "reactomeId" : 10699914, "displayName" : "p6S, T-SMO dimer:CSNK1A1:ADRBK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 605, "y" : 413 }, "minX" : 545, "maxX" : 672, "minY" : 389, "maxY" : 431, "prop" : { "x" : 545, "y" : 395, "width" : 121, "height" : 36 }, "textPosition" : { "x" : 545, "y" : 396 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 666, "y" : 395 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 666, "y" : 395 } } }, "connectors" : [ { "edgeId" : 38131, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38133, "reactomeId" : 10699901, "displayName" : "CSNK1A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 720, "y" : 942 }, "minX" : 599, "maxX" : 848, "minY" : 341, "maxY" : 955, "prop" : { "x" : 676, "y" : 929, "width" : 88, "height" : 26 }, "textPosition" : { "x" : 688, "y" : 931 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 764, "y" : 929 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 764, "y" : 929 } } }, "connectors" : [ { "edgeId" : 38131, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 723, "y" : 926 }, "to" : { "x" : 848, "y" : 496 } }, { "from" : { "x" : 848, "y" : 496 }, "to" : { "x" : 599, "y" : 341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 721, "y" : 918 }, "b" : { "x" : 723, "y" : 926 }, "c" : { "x" : 729, "y" : 920 }, "type" : "ARROW", "centre" : { "x" : 729, "y" : 920 } } } ] }, { "id" : 38134, "reactomeId" : 10699912, "displayName" : "p6S, T-SMO dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 598, "y" : 305 }, "minX" : 540, "maxX" : 663, "minY" : 288, "maxY" : 341, "prop" : { "x" : 540, "y" : 294, "width" : 117, "height" : 22 }, "textPosition" : { "x" : 540, "y" : 295 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 657, "y" : 294 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 657, "y" : 294 } } }, "connectors" : [ { "edgeId" : 38131, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 598, "y" : 319 }, "to" : { "x" : 599, "y" : 341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 602, "y" : 326 }, "b" : { "x" : 598, "y" : 319 }, "c" : { "x" : 594, "y" : 326 }, "type" : "ARROW", "centre" : { "x" : 594, "y" : 326 } } } ] }, { "id" : 38135, "reactomeId" : 10699899, "displayName" : "ADRBK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 729, "y" : 650 }, "minX" : 599, "maxX" : 803, "minY" : 341, "maxY" : 661, "prop" : { "x" : 701, "y" : 639, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 701, "y" : 639 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 758, "y" : 639 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 758, "y" : 639 } } }, "connectors" : [ { "edgeId" : 38131, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 734, "y" : 636 }, "to" : { "x" : 803, "y" : 503 } }, { "from" : { "x" : 803, "y" : 503 }, "to" : { "x" : 599, "y" : 341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 734, "y" : 628 }, "b" : { "x" : 734, "y" : 636 }, "c" : { "x" : 741, "y" : 632 }, "type" : "ARROW", "centre" : { "x" : 741, "y" : 632 } } } ] }, { "id" : 38137, "reactomeId" : 10675365, "displayName" : "hhip", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 417, "y" : 44 }, "minX" : 291, "maxX" : 442, "minY" : 27, "maxY" : 107, "prop" : { "x" : 399, "y" : 33, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 400, "y" : 33 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 436, "y" : 33 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 436, "y" : 33 } } }, "connectors" : [ { "edgeId" : 38136, "type" : "INPUT", "segments" : [ { "from" : { "x" : 396, "y" : 53 }, "to" : { "x" : 291, "y" : 107 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38138, "reactomeId" : 10675381, "displayName" : "Hh-Npp:HHIP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 420, "y" : 129 }, "minX" : 380, "maxX" : 466, "minY" : 106, "maxY" : 147, "prop" : { "x" : 380, "y" : 112, "width" : 80, "height" : 35 }, "textPosition" : { "x" : 391, "y" : 112 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 460, "y" : 112 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 460, "y" : 112 } } }, "connectors" : [ { "edgeId" : 38136, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38140, "reactomeId" : 10698476, "displayName" : "sufu", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 997, "y" : 1071 }, "minX" : 966, "maxX" : 1047, "minY" : 1051, "maxY" : 1101, "prop" : { "x" : 966, "y" : 1057, "width" : 62, "height" : 28 }, "textPosition" : { "x" : 979, "y" : 1060 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1028, "y" : 1057 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1028, "y" : 1057 } } }, "connectors" : [ { "edgeId" : 38139, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1020, "y" : 1088 }, "to" : { "x" : 1047, "y" : 1101 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38141, "reactomeId" : 10698474, "displayName" : "GLI1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1000, "y" : 1130 }, "minX" : 959, "maxX" : 1047, "minY" : 1101, "maxY" : 1142, "prop" : { "x" : 959, "y" : 1118, "width" : 82, "height" : 24 }, "textPosition" : { "x" : 971, "y" : 1119 }, "connectors" : [ { "edgeId" : 38139, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1019, "y" : 1112 }, "to" : { "x" : 1047, "y" : 1101 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38142, "reactomeId" : 10698478, "displayName" : "GLI:SUFU", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1158, "y" : 1103 }, "minX" : 1123, "maxX" : 1200, "minY" : 1084, "maxY" : 1116, "prop" : { "x" : 1123, "y" : 1090, "width" : 71, "height" : 26 }, "textPosition" : { "x" : 1127, "y" : 1095 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1194, "y" : 1090 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1194, "y" : 1090 } } }, "connectors" : [ { "edgeId" : 38139, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 38176, "reactomeId" : 10698575, "displayName" : "NUMB binds ITCH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2214, "y" : 1265 }, "minX" : 2208, "maxX" : 2220, "minY" : 1237, "maxY" : 1296, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2214, "y" : 1237 }, "to" : { "x" : 2214, "y" : 1265 } }, { "from" : { "x" : 2214, "y" : 1265 }, "to" : { "x" : 2220, "y" : 1296 } } ], "endShape" : { "a" : { "x" : 2215, "y" : 1290 }, "b" : { "x" : 2220, "y" : 1296 }, "c" : { "x" : 2223, "y" : 1288 }, "type" : "ARROW", "centre" : { "x" : 2223, "y" : 1288 } }, "reactionShape" : { "c" : { "x" : 2214, "y" : 1265 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2214, "y" : 1265 } }, "inputs" : [ { "id" : 38177, "points" : [ { "x" : 2230, "y" : 1219 } ] }, { "id" : 38178, "points" : [ { "x" : 2182, "y" : 1221 } ] } ], "outputs" : [ { "id" : 38179 } ] }, { "id" : 38116, "reactomeId" : 10699875, "displayName" : "Hh-Npp binds CDON and PTCH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 336, "y" : 532 }, "minX" : 330, "maxX" : 385, "minY" : 526, "maxY" : 574, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 334, "y" : 574 }, "to" : { "x" : 336, "y" : 532 } }, { "from" : { "x" : 336, "y" : 532 }, "to" : { "x" : 385, "y" : 527 } } ], "endShape" : { "a" : { "x" : 379, "y" : 532 }, "b" : { "x" : 385, "y" : 527 }, "c" : { "x" : 378, "y" : 524 }, "type" : "ARROW", "centre" : { "x" : 378, "y" : 524 } }, "reactionShape" : { "c" : { "x" : 336, "y" : 532 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 336, "y" : 532 } }, "inputs" : [ { "id" : 38117, "points" : [ { "x" : 391, "y" : 591 } ] }, { "id" : 38118, "points" : [ { "x" : 67, "y" : 616 } ] }, { "id" : 38119, "points" : [ { "x" : 394, "y" : 634 } ] } ], "outputs" : [ { "id" : 38120 } ] }, { "id" : 38148, "reactomeId" : 10700000, "displayName" : "GLI translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1312, "y" : 526 }, "minX" : 1296, "maxX" : 1383, "minY" : 357, "maxY" : 1252, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1296, "y" : 357 }, "to" : { "x" : 1312, "y" : 526 } }, { "from" : { "x" : 1312, "y" : 526 }, "to" : { "x" : 1383, "y" : 1252 } } ], "endShape" : { "a" : { "x" : 1378, "y" : 1245 }, "b" : { "x" : 1383, "y" : 1252 }, "c" : { "x" : 1386, "y" : 1245 }, "type" : "ARROW", "centre" : { "x" : 1386, "y" : 1245 } }, "reactionShape" : { "a" : { "x" : 1306, "y" : 520 }, "b" : { "x" : 1318, "y" : 532 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1312, "y" : 526 } }, "inputs" : [ { "id" : 38149 } ], "outputs" : [ { "id" : 38150 } ] }, { "id" : 38180, "reactomeId" : 10700052, "displayName" : "NUMB:ITCH binds GLI1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2257, "y" : 1393 }, "minX" : 2230, "maxX" : 2293, "minY" : 1387, "maxY" : 1399, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2230, "y" : 1393 }, "to" : { "x" : 2257, "y" : 1393 } }, { "from" : { "x" : 2257, "y" : 1393 }, "to" : { "x" : 2293, "y" : 1395 } } ], "endShape" : { "a" : { "x" : 2286, "y" : 1399 }, "b" : { "x" : 2293, "y" : 1395 }, "c" : { "x" : 2286, "y" : 1391 }, "type" : "ARROW", "centre" : { "x" : 2286, "y" : 1391 } }, "reactionShape" : { "c" : { "x" : 2257, "y" : 1393 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2257, "y" : 1393 } }, "inputs" : [ { "id" : 38179, "points" : [ { "x" : 2223, "y" : 1324 } ] }, { "id" : 38181, "points" : [ { "x" : 2198, "y" : 1393 } ] } ], "outputs" : [ { "id" : 38182 } ] }, { "id" : 38183, "reactomeId" : 10700059, "displayName" : "NUMB:ITCH ubiquitinates GLI1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2418, "y" : 1400 }, "minX" : 2398, "maxX" : 2443, "minY" : 1394, "maxY" : 1406, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2398, "y" : 1400 }, "to" : { "x" : 2418, "y" : 1400 } }, { "from" : { "x" : 2418, "y" : 1400 }, "to" : { "x" : 2443, "y" : 1398 } } ], "endShape" : { "a" : { "x" : 2436, "y" : 1403 }, "b" : { "x" : 2443, "y" : 1398 }, "c" : { "x" : 2436, "y" : 1395 }, "type" : "ARROW", "centre" : { "x" : 2436, "y" : 1395 } }, "reactionShape" : { "a" : { "x" : 2412, "y" : 1394 }, "b" : { "x" : 2424, "y" : 1406 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2418, "y" : 1400 } }, "inputs" : [ { "id" : 38182, "points" : [ { "x" : 2382, "y" : 1399 } ] }, { "id" : 38184, "points" : [ { "x" : 2372, "y" : 1359 } ] } ], "outputs" : [ { "id" : 38185 } ], "catalysts" : [ { "id" : 38182, "points" : [ { "x" : 2353, "y" : 1418 }, { "x" : 2377, "y" : 1439 } ] } ] }, { "id" : 38151, "reactomeId" : 10700063, "displayName" : "SMURF1/2 dissociates from ub-PTCH1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 412, "y" : 913 }, "minX" : 406, "maxX" : 418, "minY" : 899, "maxY" : 933, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 415, "y" : 899 }, "to" : { "x" : 412, "y" : 913 } }, { "from" : { "x" : 412, "y" : 913 }, "to" : { "x" : 411, "y" : 933 } } ], "reactionShape" : { "c" : { "x" : 412, "y" : 913 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 412, "y" : 913 } }, "inputs" : [ { "id" : 38152 } ], "outputs" : [ { "id" : 38153, "points" : [ { "x" : 202, "y" : 1077 }, { "x" : 305, "y" : 1139 }, { "x" : 379, "y" : 961 } ] }, { "id" : 38125, "points" : [ { "x" : 415, "y" : 968 } ] } ] }, { "id" : 38121, "reactomeId" : 10699871, "displayName" : "Hh-Npp binds GAS1 and PTCH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 319, "y" : 383 }, "minX" : 309, "maxX" : 368, "minY" : 377, "maxY" : 404, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 309, "y" : 404 }, "to" : { "x" : 319, "y" : 383 } }, { "from" : { "x" : 319, "y" : 383 }, "to" : { "x" : 368, "y" : 379 } } ], "endShape" : { "a" : { "x" : 361, "y" : 384 }, "b" : { "x" : 368, "y" : 379 }, "c" : { "x" : 361, "y" : 376 }, "type" : "ARROW", "centre" : { "x" : 361, "y" : 376 } }, "reactionShape" : { "c" : { "x" : 319, "y" : 383 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 319, "y" : 383 } }, "inputs" : [ { "id" : 38122, "points" : [ { "x" : 382, "y" : 441 } ] }, { "id" : 38118, "points" : [ { "x" : 44, "y" : 604 } ] }, { "id" : 38119, "points" : [ { "x" : 384, "y" : 634 }, { "x" : 284, "y" : 575 } ] } ], "outputs" : [ { "id" : 38123 } ] }, { "id" : 38186, "reactomeId" : 10700065, "displayName" : "ub-GLI is degraded by the proteasome", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2495, "y" : 1281 }, "minX" : 2413, "maxX" : 2501, "minY" : 1267, "maxY" : 1371, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2493, "y" : 1371 }, "to" : { "x" : 2495, "y" : 1281 } }, { "from" : { "x" : 2495, "y" : 1281 }, "to" : { "x" : 2413, "y" : 1267 } } ], "reactionShape" : { "a" : { "x" : 2489, "y" : 1275 }, "b" : { "x" : 2501, "y" : 1287 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2495, "y" : 1281 } }, "inputs" : [ { "id" : 38185 } ], "outputs" : [ { "id" : 38179, "points" : [ { "x" : 2264, "y" : 1301 } ] }, { "id" : 38184, "points" : [ { "x" : 2375, "y" : 1313 } ] } ], "catalysts" : [ { "id" : 38187, "points" : [ { "x" : 2492, "y" : 1245 } ] } ] }, { "id" : 38154, "reactomeId" : 10699968, "displayName" : "ULK3:SUFU dissociates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1045, "y" : 110 }, "minX" : 1009, "maxX" : 1075, "minY" : 95, "maxY" : 125, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 1009, "y" : 95 }, "to" : { "x" : 1045, "y" : 110 } }, { "from" : { "x" : 1045, "y" : 110 }, "to" : { "x" : 1075, "y" : 125 } } ], "reactionShape" : { "c" : { "x" : 1045, "y" : 110 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 1045, "y" : 110 } }, "inputs" : [ { "id" : 38155 } ], "outputs" : [ { "id" : 38146, "points" : [ { "x" : 1097, "y" : 208 } ] }, { "id" : 38156, "points" : [ { "x" : 1240, "y" : 101 } ] } ] }, { "id" : 38124, "reactomeId" : 10699884, "displayName" : "PTCH is internalized", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 427, "y" : 1121 }, "minX" : 418, "maxX" : 433, "minY" : 1008, "maxY" : 1310, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 418, "y" : 1008 }, "to" : { "x" : 427, "y" : 1121 } }, { "from" : { "x" : 427, "y" : 1121 }, "to" : { "x" : 432, "y" : 1310 } } ], "endShape" : { "a" : { "x" : 428, "y" : 1303 }, "b" : { "x" : 432, "y" : 1310 }, "c" : { "x" : 436, "y" : 1303 }, "type" : "ARROW", "centre" : { "x" : 436, "y" : 1303 } }, "reactionShape" : { "a" : { "x" : 421, "y" : 1115 }, "b" : { "x" : 433, "y" : 1127 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 427, "y" : 1121 } }, "inputs" : [ { "id" : 38125 } ], "outputs" : [ { "id" : 38126 } ] }, { "id" : 38157, "reactomeId" : 10699998, "displayName" : "ULK3 phosphorylates GLI", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1287, "y" : 214 }, "minX" : 1253, "maxX" : 1293, "minY" : 208, "maxY" : 240, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1253, "y" : 209 }, "to" : { "x" : 1287, "y" : 214 } }, { "from" : { "x" : 1287, "y" : 214 }, "to" : { "x" : 1291, "y" : 240 } } ], "reactionShape" : { "a" : { "x" : 1281, "y" : 208 }, "b" : { "x" : 1293, "y" : 220 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1287, "y" : 214 } }, "inputs" : [ { "id" : 38145, "points" : [ { "x" : 1218, "y" : 210 } ] }, { "id" : 38158, "points" : [ { "x" : 1232, "y" : 186 } ] } ], "outputs" : [ { "id" : 38159, "points" : [ { "x" : 1256, "y" : 264 } ] }, { "id" : 38149, "points" : [ { "x" : 1294, "y" : 309 } ] } ], "catalysts" : [ { "id" : 38156, "points" : [ { "x" : 1265, "y" : 113 } ] } ] }, { "id" : 38127, "reactomeId" : 10699940, "displayName" : "EFCAB7:IQCE binds EVC2:EVC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 729, "y" : 109 }, "minX" : 683, "maxX" : 736, "minY" : 45, "maxY" : 150, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 683, "y" : 150 }, "to" : { "x" : 729, "y" : 109 } }, { "from" : { "x" : 729, "y" : 109 }, "to" : { "x" : 736, "y" : 45 } } ], "endShape" : { "a" : { "x" : 739, "y" : 52 }, "b" : { "x" : 736, "y" : 45 }, "c" : { "x" : 731, "y" : 51 }, "type" : "ARROW", "centre" : { "x" : 731, "y" : 51 } }, "reactionShape" : { "c" : { "x" : 729, "y" : 109 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 729, "y" : 109 } }, "inputs" : [ { "id" : 38128, "points" : [ { "x" : 657, "y" : 97 } ] }, { "id" : 38129, "points" : [ { "x" : 634, "y" : 150 } ] } ], "outputs" : [ { "id" : 38130 } ] }, { "id" : 38160, "reactomeId" : 10699960, "displayName" : "GPR161 is internalized", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 499, "y" : 1087 }, "minX" : 491, "maxX" : 505, "minY" : 952, "maxY" : 1264, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 491, "y" : 952 }, "to" : { "x" : 499, "y" : 1087 } }, { "from" : { "x" : 499, "y" : 1087 }, "to" : { "x" : 497, "y" : 1264 } } ], "endShape" : { "a" : { "x" : 493, "y" : 1257 }, "b" : { "x" : 497, "y" : 1264 }, "c" : { "x" : 501, "y" : 1257 }, "type" : "ARROW", "centre" : { "x" : 501, "y" : 1257 } }, "reactionShape" : { "a" : { "x" : 493, "y" : 1081 }, "b" : { "x" : 505, "y" : 1093 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 499, "y" : 1087 } }, "inputs" : [ { "id" : 38161 } ], "outputs" : [ { "id" : 38162 } ] }, { "id" : 38163, "reactomeId" : 10700004, "displayName" : "GLI proteins bind CDC73", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1685, "y" : 1155 }, "minX" : 1656, "maxX" : 1744, "minY" : 1149, "maxY" : 1161, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1656, "y" : 1154 }, "to" : { "x" : 1685, "y" : 1155 } }, { "from" : { "x" : 1685, "y" : 1155 }, "to" : { "x" : 1744, "y" : 1154 } } ], "endShape" : { "a" : { "x" : 1737, "y" : 1158 }, "b" : { "x" : 1744, "y" : 1154 }, "c" : { "x" : 1737, "y" : 1150 }, "type" : "ARROW", "centre" : { "x" : 1737, "y" : 1150 } }, "reactionShape" : { "c" : { "x" : 1685, "y" : 1155 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1685, "y" : 1155 } }, "inputs" : [ { "id" : 38164, "points" : [ { "x" : 1605, "y" : 1154 } ] }, { "id" : 38165, "points" : [ { "x" : 1602, "y" : 1246 } ] } ], "outputs" : [ { "id" : 38166 } ] }, { "id" : 38131, "reactomeId" : 10699916, "displayName" : "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 597, "y" : 367 }, "minX" : 591, "maxX" : 603, "minY" : 341, "maxY" : 392, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 601, "y" : 392 }, "to" : { "x" : 597, "y" : 367 } }, { "from" : { "x" : 597, "y" : 367 }, "to" : { "x" : 599, "y" : 341 } } ], "reactionShape" : { "c" : { "x" : 597, "y" : 367 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 597, "y" : 367 } }, "inputs" : [ { "id" : 38132 } ], "outputs" : [ { "id" : 38133, "points" : [ { "x" : 723, "y" : 926 }, { "x" : 848, "y" : 496 } ] }, { "id" : 38134, "points" : [ { "x" : 598, "y" : 319 } ] }, { "id" : 38135, "points" : [ { "x" : 734, "y" : 636 }, { "x" : 803, "y" : 503 } ] } ] }, { "id" : 38167, "reactomeId" : 10700040, "displayName" : "phosphorylated GLI proteins bind SPOP:CUL3:RBX1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1505, "y" : 1714 }, "minX" : 1482, "maxX" : 1542, "minY" : 1708, "maxY" : 1720, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1482, "y" : 1715 }, "to" : { "x" : 1505, "y" : 1714 } }, { "from" : { "x" : 1505, "y" : 1714 }, "to" : { "x" : 1542, "y" : 1714 } } ], "endShape" : { "a" : { "x" : 1535, "y" : 1718 }, "b" : { "x" : 1542, "y" : 1714 }, "c" : { "x" : 1535, "y" : 1710 }, "type" : "ARROW", "centre" : { "x" : 1535, "y" : 1710 } }, "reactionShape" : { "c" : { "x" : 1505, "y" : 1714 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1505, "y" : 1714 } }, "inputs" : [ { "id" : 38168, "points" : [ { "x" : 1447, "y" : 1717 } ] }, { "id" : 38169, "points" : [ { "x" : 1375, "y" : 1529 } ] } ], "outputs" : [ { "id" : 38170 } ] }, { "id" : 38136, "reactomeId" : 10675383, "displayName" : "HHIP binds Hedgehog", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 291, "y" : 121 }, "minX" : 285, "maxX" : 377, "minY" : 107, "maxY" : 127, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 291, "y" : 107 }, "to" : { "x" : 291, "y" : 121 } }, { "from" : { "x" : 291, "y" : 121 }, "to" : { "x" : 377, "y" : 126 } } ], "endShape" : { "a" : { "x" : 370, "y" : 130 }, "b" : { "x" : 377, "y" : 126 }, "c" : { "x" : 370, "y" : 122 }, "type" : "ARROW", "centre" : { "x" : 370, "y" : 122 } }, "reactionShape" : { "c" : { "x" : 291, "y" : 121 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 291, "y" : 121 } }, "inputs" : [ { "id" : 38118, "points" : [ { "x" : 35, "y" : 604 } ] }, { "id" : 38137, "points" : [ { "x" : 396, "y" : 53 } ] } ], "outputs" : [ { "id" : 38138 } ] }, { "id" : 38171, "reactomeId" : 10700043, "displayName" : "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1697, "y" : 1714 }, "minX" : 1670, "maxX" : 1726, "minY" : 1708, "maxY" : 1720, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1670, "y" : 1715 }, "to" : { "x" : 1697, "y" : 1714 } }, { "from" : { "x" : 1697, "y" : 1714 }, "to" : { "x" : 1726, "y" : 1714 } } ], "endShape" : { "a" : { "x" : 1719, "y" : 1718 }, "b" : { "x" : 1726, "y" : 1714 }, "c" : { "x" : 1719, "y" : 1710 }, "type" : "ARROW", "centre" : { "x" : 1719, "y" : 1710 } }, "reactionShape" : { "a" : { "x" : 1691, "y" : 1708 }, "b" : { "x" : 1703, "y" : 1720 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1697, "y" : 1714 } }, "inputs" : [ { "id" : 38170, "points" : [ { "x" : 1631, "y" : 1715 } ] }, { "id" : 38172, "points" : [ { "x" : 1655, "y" : 1751 } ] } ], "outputs" : [ { "id" : 38173 } ], "catalysts" : [ { "id" : 38170, "points" : [ { "x" : 1631, "y" : 1699 }, { "x" : 1663, "y" : 1686 } ] } ] }, { "id" : 38139, "reactomeId" : 10698480, "displayName" : "GLI proteins bind SUFU", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1080, "y" : 1103 }, "minX" : 1047, "maxX" : 1120, "minY" : 1097, "maxY" : 1109, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1047, "y" : 1101 }, "to" : { "x" : 1080, "y" : 1103 } }, { "from" : { "x" : 1080, "y" : 1103 }, "to" : { "x" : 1120, "y" : 1103 } } ], "endShape" : { "a" : { "x" : 1113, "y" : 1107 }, "b" : { "x" : 1120, "y" : 1103 }, "c" : { "x" : 1113, "y" : 1099 }, "type" : "ARROW", "centre" : { "x" : 1113, "y" : 1099 } }, "reactionShape" : { "c" : { "x" : 1080, "y" : 1103 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1080, "y" : 1103 } }, "inputs" : [ { "id" : 38140, "points" : [ { "x" : 1020, "y" : 1088 } ] }, { "id" : 38141, "points" : [ { "x" : 1019, "y" : 1112 } ] } ], "outputs" : [ { "id" : 38142 } ] }, { "id" : 38174, "reactomeId" : 10700034, "displayName" : "GLI2,3 are degraded by the proteasome", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1881, "y" : 1718 }, "minX" : 1851, "maxX" : 1887, "minY" : 1712, "maxY" : 1826, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1851, "y" : 1716 }, "to" : { "x" : 1881, "y" : 1718 } }, { "from" : { "x" : 1881, "y" : 1718 }, "to" : { "x" : 1883, "y" : 1826 } } ], "reactionShape" : { "a" : { "x" : 1875, "y" : 1712 }, "b" : { "x" : 1887, "y" : 1724 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1881, "y" : 1718 } }, "inputs" : [ { "id" : 38173 } ], "outputs" : [ { "id" : 38168, "points" : [ { "x" : 1390, "y" : 1735 }, { "x" : 1412, "y" : 1831 } ] }, { "id" : 38172, "points" : [ { "x" : 1689, "y" : 1775 } ] } ], "catalysts" : [ { "id" : 38175, "points" : [ { "x" : 1916, "y" : 1695 } ] } ] }, { "id" : 38143, "reactomeId" : 10700047, "displayName" : "GLI:SUFU dissociates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1139, "y" : 295 }, "minX" : 1133, "maxX" : 1145, "minY" : 269, "maxY" : 320, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 1138, "y" : 320 }, "to" : { "x" : 1139, "y" : 295 } }, { "from" : { "x" : 1139, "y" : 295 }, "to" : { "x" : 1139, "y" : 269 } } ], "reactionShape" : { "c" : { "x" : 1139, "y" : 295 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 1139, "y" : 295 } }, "inputs" : [ { "id" : 38144 } ], "outputs" : [ { "id" : 38145, "points" : [ { "x" : 1167, "y" : 230 } ] }, { "id" : 38146, "points" : [ { "x" : 1109, "y" : 236 } ] } ], "activators" : [ { "id" : 38147, "points" : [ { "x" : 692, "y" : 231 } ] } ] } ], "compartments" : [ { "id" : 38198, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1665, "y" : 1488 }, "minX" : 1296, "maxX" : 2035, "minY" : 1081, "maxY" : 1895, "prop" : { "x" : 1296, "y" : 1081, "width" : 739, "height" : 814 }, "textPosition" : { "x" : 1428, "y" : 1128 }, "insets" : { "x" : 1306, "y" : 1091, "width" : 719, "height" : 794 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38150, 38165, 38201, 38203, 38164, 38163, 38166, 38204, 38167, 38168, 38169, 38170, 38173, 38171, 38172, 38175, 38174 ] }, { "id" : 38202, "reactomeId" : 18730, "displayName" : "cilium", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 907, "y" : 507 }, "minX" : 401, "maxX" : 1413, "minY" : 12, "maxY" : 1003, "prop" : { "x" : 401, "y" : 12, "width" : 1012, "height" : 991 }, "textPosition" : { "x" : 880, "y" : 491 }, "insets" : { "x" : 411, "y" : 22, "width" : 992, "height" : 971 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38151, 38147, 38128, 38127 ] }, { "id" : 38188, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1350, "y" : 1507 }, "minX" : 86, "maxX" : 2614, "minY" : 987, "maxY" : 2028, "prop" : { "x" : 86, "y" : 987, "width" : 2528, "height" : 1041 }, "textPosition" : { "x" : 1042, "y" : 1323 }, "insets" : { "x" : 96, "y" : 997, "width" : 2508, "height" : 1021 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38153, 38189, 38139, 38140, 38141, 38142, 38198, 38124, 38160, 38176, 38179, 38178, 38177, 38181, 38182, 38180, 38183, 38185, 38184, 38186, 38187 ] }, { "id" : 38189, "reactomeId" : 528865, "displayName" : "endocytic vesicle lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 707, "y" : 1372 }, "minX" : 412, "maxX" : 1002, "minY" : 1280, "maxY" : 1465, "prop" : { "x" : 412, "y" : 1280, "width" : 590, "height" : 185 }, "textPosition" : { "x" : 764, "y" : 1386 }, "insets" : { "x" : 422, "y" : 1290, "width" : 570, "height" : 165 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38126, 38162 ] } ], "notes" : [ ], "links" : [ { "id" : 38203, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1543, "y" : 1403 }, "minX" : 1499, "maxX" : 1587, "minY" : 1291, "maxY" : 1515, "segments" : [ { "from" : { "x" : 1499, "y" : 1515 }, "to" : { "x" : 1587, "y" : 1291 } } ], "reactionShape" : { "a" : { "x" : 1537, "y" : 1397 }, "b" : { "x" : 1549, "y" : 1409 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1543, "y" : 1403 } }, "inputs" : [ { "id" : 38201 } ], "outputs" : [ { "id" : 38165 } ] }, { "id" : 38204, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1478, "y" : 1393 }, "minX" : 1379, "maxX" : 1578, "minY" : 1291, "maxY" : 1495, "segments" : [ { "from" : { "x" : 1379, "y" : 1495 }, "to" : { "x" : 1578, "y" : 1291 } } ], "reactionShape" : { "a" : { "x" : 1472, "y" : 1387 }, "b" : { "x" : 1484, "y" : 1399 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1478, "y" : 1393 } }, "inputs" : [ { "id" : 38169 } ], "outputs" : [ { "id" : 38165 } ] } ], "shadows" : [ { "id" : 38205, "reactomeId" : 10730030, "displayName" : "Ligand-receptor interactions", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 236, "y" : 348 }, "minX" : -10, "maxX" : 482, "minY" : 23, "maxY" : 674, "prop" : { "x" : -10, "y" : 23, "width" : 492, "height" : 651 }, "points" : [ { "x" : -10, "y" : 23 }, { "x" : 482, "y" : 23 }, { "x" : 482, "y" : 674 }, { "x" : -10, "y" : 674 } ], "colour" : "#4684ee" }, { "id" : 38206, "reactomeId" : 10730818, "displayName" : "Activation of SMO", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 664, "y" : 480 }, "minX" : 530, "maxX" : 799, "minY" : -4, "maxY" : 965, "prop" : { "x" : 530, "y" : -4, "width" : 269, "height" : 969 }, "points" : [ { "x" : 530, "y" : -4 }, { "x" : 799, "y" : -4 }, { "x" : 799, "y" : 965 }, { "x" : 530, "y" : 965 } ], "colour" : "#dc3912" } ], "minX" : 0, "maxX" : 2614, "minY" : 0, "maxY" : 2028, "disease" : false }