{
  "dbId" : 10729620,
  "stId" : "R-XTR-211000",
  "speciesName" : "Xenopus tropicalis",
  "nodes" : [ {
    "dbId" : 10667171,
    "stId" : "R-XTR-2106620",
    "displayName" : "AGO1:duplex miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10667177 ],
    "children" : [ 10667167, 10666315 ]
  }, {
    "dbId" : 10667169,
    "stId" : "R-XTR-2106619",
    "displayName" : "AGO2:duplex miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10667177 ],
    "children" : [ 10667167, 10666311 ]
  }, {
    "dbId" : 10654881,
    "stId" : "R-XTR-113401",
    "displayName" : "RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21664 ],
    "parents" : [ 10698178 ],
    "children" : [ 10653836, 10654879, 10653822, 10653848, 10653832, 10653850, 10653818, 10653844, 10653828, 10653814, 10653840, 10653826 ]
  }, {
    "dbId" : 10654630,
    "stId" : "R-XTR-181902",
    "displayName" : "h4c3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "B5DDY3",
    "standardIdentifier" : "uniprot:B5DDY3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "h4c3" ],
    "parents" : [ 10654705 ],
    "children" : [ ]
  }, {
    "dbId" : 10673830,
    "stId" : "R-XTR-203852",
    "displayName" : "Endonucleolytic RISC [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 21646 ],
    "parents" : [ 10673840 ],
    "children" : [ 10667183, 10673828 ]
  }, {
    "dbId" : 10667175,
    "stId" : "R-XTR-2106602",
    "displayName" : "AGO4:duplex miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10667177 ],
    "children" : [ 10667167, 10666323 ]
  }, {
    "dbId" : 10673828,
    "stId" : "R-XTR-2106601",
    "displayName" : "AGO2:siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21670 ],
    "parents" : [ 10688639, 10673830 ],
    "children" : [ 426446, 10666311 ]
  }, {
    "dbId" : 10667173,
    "stId" : "R-XTR-2106606",
    "displayName" : "AGO3:duplex miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10667177 ],
    "children" : [ 10667167, 10666319 ]
  }, {
    "dbId" : 10654634,
    "stId" : "R-XTR-181887",
    "displayName" : "h2ac17 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A8J0SEC6",
    "standardIdentifier" : "uniprot:A0A8J0SEC6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "h2ac17" ],
    "parents" : [ 10654678 ],
    "children" : [ ]
  }, {
    "dbId" : 10673834,
    "stId" : "R-XTR-2106622",
    "displayName" : "AGO3:siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10688639, 10673838 ],
    "children" : [ 10666319, 426446 ]
  }, {
    "dbId" : 10667179,
    "stId" : "R-XTR-6789269",
    "displayName" : "PRKRA:DICER1:Pre-RISC (miRNA) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21637 ],
    "parents" : [ ],
    "children" : [ 10666303, 10667177, 10666307 ]
  }, {
    "dbId" : 426511,
    "stId" : "R-ALL-426511",
    "displayName" : "Cleaved RNA with 5' Phosphate and 3' Hydroxyl [cytosol]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "diagramIds" : [ 21645 ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10673832,
    "stId" : "R-XTR-2106624",
    "displayName" : "AGO1:siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10688639, 10673838 ],
    "children" : [ 10666315, 426446 ]
  }, {
    "dbId" : 10667177,
    "stId" : "R-XTR-2106632",
    "displayName" : "pre-RISC (miRNA) [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10667179 ],
    "children" : [ 10667169, 10667173, 10667175, 10667171 ]
  }, {
    "dbId" : 10654638,
    "stId" : "R-XTR-181888",
    "displayName" : "LOC100487067 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8R705",
    "standardIdentifier" : "uniprot:A0A6I8R705",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC100487067" ],
    "parents" : [ 10654664 ],
    "children" : [ ]
  }, {
    "dbId" : 10673838,
    "stId" : "R-XTR-210807",
    "displayName" : "Nonendonucleolytic RISC [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 21653 ],
    "parents" : [ 10673859, 10673840 ],
    "children" : [ 10673836, 10673832, 10673834, 10667189, 10667185, 10667187 ]
  }, {
    "dbId" : 10667183,
    "stId" : "R-XTR-2106621",
    "displayName" : "AGO2:miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10667191, 10673830 ],
    "children" : [ 10667181, 10666311 ]
  }, {
    "dbId" : 10673836,
    "stId" : "R-XTR-2106627",
    "displayName" : "AGO4:siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10688639, 10673838 ],
    "children" : [ 426446, 10666323 ]
  }, {
    "dbId" : 10667181,
    "stId" : "R-XTR-8963816",
    "displayName" : "Ghost homologue of miRNA [cytosol]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10667187, 10667185, 10667189, 10667183 ],
    "children" : [ ]
  }, {
    "dbId" : 10654642,
    "stId" : "R-XTR-181888-2",
    "displayName" : "LOC100485548 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8S5P5",
    "standardIdentifier" : "uniprot:A0A6I8S5P5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC100485548" ],
    "parents" : [ 10654664 ],
    "children" : [ ]
  }, {
    "dbId" : 10667187,
    "stId" : "R-XTR-2106613",
    "displayName" : "AGO3:miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10673838, 10667191 ],
    "children" : [ 10667181, 10666319 ]
  }, {
    "dbId" : 10673840,
    "stId" : "R-XTR-427783",
    "displayName" : "RISC [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 21649 ],
    "parents" : [ 10673852 ],
    "children" : [ 10673838, 10673830 ]
  }, {
    "dbId" : 10667185,
    "stId" : "R-XTR-2106629",
    "displayName" : "AGO1:miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10673838, 10667191 ],
    "children" : [ 10667181, 10666315 ]
  }, {
    "dbId" : 10654646,
    "stId" : "R-XTR-181888-3",
    "displayName" : "LOC100487632 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8S7P0",
    "standardIdentifier" : "uniprot:A0A6I8S7P0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC100487632" ],
    "parents" : [ 10654664 ],
    "children" : [ ]
  }, {
    "dbId" : 10667191,
    "stId" : "R-XTR-2106628",
    "displayName" : "RISC (miRNA) [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10667193 ],
    "children" : [ 10667183, 10667189, 10667185, 10667187 ]
  }, {
    "dbId" : 10698166,
    "stId" : "R-XTR-5578701",
    "displayName" : "AGO2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6DJB9",
    "standardIdentifier" : "uniprot:Q6DJB9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10698170 ],
    "children" : [ ]
  }, {
    "dbId" : 426515,
    "stId" : "R-ALL-426515",
    "displayName" : "RNA (inexact match) [cytosol]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "diagramIds" : [ 21650 ],
    "parents" : [ 10673852 ],
    "children" : [ ]
  }, {
    "dbId" : 10673844,
    "stId" : "R-XTR-427777",
    "displayName" : "tnrc6b [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8SYR1",
    "standardIdentifier" : "uniprot:A0A6I8SYR1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "tnrc6b" ],
    "parents" : [ 10673850 ],
    "children" : [ ]
  }, {
    "dbId" : 10667189,
    "stId" : "R-XTR-2106626",
    "displayName" : "AGO4:miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10673838, 10667191 ],
    "children" : [ 10667181, 10666323 ]
  }, {
    "dbId" : 10654650,
    "stId" : "R-XTR-181888-4",
    "displayName" : "LOC116407737 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8SFV2",
    "standardIdentifier" : "uniprot:A0A6I8SFV2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC116407737" ],
    "parents" : [ 10654664 ],
    "children" : [ ]
  }, {
    "dbId" : 10673850,
    "stId" : "R-XTR-427775",
    "displayName" : "TNRC6 (GW182) [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 21648 ],
    "parents" : [ 10673852, 10673859 ],
    "children" : [ 10673844, 10673848 ]
  }, {
    "dbId" : 10698170,
    "stId" : "R-XTR-5578695",
    "displayName" : "AGO2:miRNA [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21680 ],
    "parents" : [ 10698176 ],
    "children" : [ 10698168, 10698166 ]
  }, {
    "dbId" : 10673848,
    "stId" : "R-XTR-427776",
    "displayName" : "tnrc6c [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8Q493",
    "standardIdentifier" : "uniprot:A0A6I8Q493",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "tnrc6c" ],
    "parents" : [ 10673850 ],
    "children" : [ ]
  }, {
    "dbId" : 10667193,
    "stId" : "R-XTR-6789261",
    "displayName" : "PRKRA:DICER1:RISC (miRNA) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21638 ],
    "parents" : [ ],
    "children" : [ 10666303, 10667191, 10666307 ]
  }, {
    "dbId" : 10698168,
    "stId" : "R-XTR-8963811",
    "displayName" : "Ghost homologue of miRNA [nucleoplasm]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10698174, 10698170 ],
    "children" : [ ]
  }, {
    "dbId" : 10654654,
    "stId" : "R-XTR-181888-5",
    "displayName" : "h2ac13 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A803J7B9",
    "standardIdentifier" : "uniprot:A0A803J7B9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "h2ac13" ],
    "parents" : [ 10654664 ],
    "children" : [ ]
  }, {
    "dbId" : 10698174,
    "stId" : "R-XTR-5578727",
    "displayName" : "AGO1:miRNA [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10698176 ],
    "children" : [ 10698172, 10698168 ]
  }, {
    "dbId" : 426523,
    "stId" : "R-ALL-426523",
    "displayName" : "RNA (exact match) [cytosol]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "diagramIds" : [ 21644 ],
    "parents" : [ 10673859 ],
    "children" : [ ]
  }, {
    "dbId" : 10673852,
    "stId" : "R-XTR-426501",
    "displayName" : "TNRC6:RISC:Target RNA (inexact match) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21651 ],
    "parents" : [ ],
    "children" : [ 10673850, 426515, 10673840 ]
  }, {
    "dbId" : 10698172,
    "stId" : "R-XTR-5578686",
    "displayName" : "ago1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F6PSN5",
    "standardIdentifier" : "uniprot:F6PSN5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ago1" ],
    "parents" : [ 10698174 ],
    "children" : [ ]
  }, {
    "dbId" : 10653826,
    "stId" : "R-XTR-63508",
    "displayName" : "polr2d [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "B3DL15",
    "standardIdentifier" : "uniprot:B3DL15",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "polr2d" ],
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10688641,
    "stId" : "R-XTR-6789245",
    "displayName" : "PRKRA:DICER1:RISC (siRNA) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21660 ],
    "parents" : [ ],
    "children" : [ 10666303, 10688639, 10666307 ]
  }, {
    "dbId" : 9023914,
    "stId" : "R-ALL-9023914",
    "displayName" : "duplex siRNA with cleaved passenger strand [cytosol]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "parents" : [ 10720514 ],
    "children" : [ ]
  }, {
    "dbId" : 10653828,
    "stId" : "R-XTR-63517",
    "displayName" : "Ghost homologue of POLR2G [nucleoplasm]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10667396,
    "stId" : "R-XTR-3211736",
    "displayName" : "Chromatin [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21663 ],
    "parents" : [ 10698178 ],
    "children" : [ 29428, 10654705 ]
  }, {
    "dbId" : 10653832,
    "stId" : "R-XTR-63506",
    "displayName" : "polr2c [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6P7Y7",
    "standardIdentifier" : "uniprot:Q6P7Y7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "polr2c" ],
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10653836,
    "stId" : "R-XTR-63523",
    "displayName" : "polr2h [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8T0M2",
    "standardIdentifier" : "uniprot:A0A6I8T0M2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "polr2h" ],
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10653840,
    "stId" : "R-XTR-63537",
    "displayName" : "polr2k [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28CR4",
    "standardIdentifier" : "uniprot:Q28CR4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "polr2k" ],
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10653844,
    "stId" : "R-XTR-83713",
    "displayName" : "polr2e [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28HF5",
    "standardIdentifier" : "uniprot:Q28HF5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "polr2e" ],
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10653850,
    "stId" : "R-XTR-83715",
    "displayName" : "Ghost homologue of POLR2L [nucleoplasm]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10653848,
    "stId" : "R-XTR-83714",
    "displayName" : "polr2f [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6DDA6",
    "standardIdentifier" : "uniprot:Q6DDA6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "polr2f" ],
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10667167,
    "stId" : "R-XTR-8963809",
    "displayName" : "Ghost homologue of duplex miRNA [cytosol]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10667169, 10667173, 10667171, 10667175, 10688623 ],
    "children" : [ ]
  }, {
    "dbId" : 10654879,
    "stId" : "R-XTR-63502",
    "displayName" : "Ghost homologue of POLR2A [nucleoplasm]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10673823,
    "stId" : "R-XTR-6789265",
    "displayName" : "PRKRA:DICER1:AGO1,2,3,4:duplex siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21642 ],
    "parents" : [ ],
    "children" : [ 426472, 10666327 ]
  }, {
    "dbId" : 10654690,
    "stId" : "R-XTR-181923-2",
    "displayName" : "LOC116411635 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8QAK0",
    "standardIdentifier" : "uniprot:A0A6I8QAK0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC116411635" ],
    "parents" : [ 10654699 ],
    "children" : [ ]
  }, {
    "dbId" : 10654694,
    "stId" : "R-XTR-181923-3",
    "displayName" : "h2bc21 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8SCA5",
    "standardIdentifier" : "uniprot:A0A6I8SCA5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "h2bc21" ],
    "parents" : [ 10654699 ],
    "children" : [ ]
  }, {
    "dbId" : 10654699,
    "stId" : "R-XTR-181923-5",
    "displayName" : "Homologues of HIST3H2BB [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10654701 ],
    "children" : [ 10654686, 10654697, 10654682, 10654694, 10654690 ]
  }, {
    "dbId" : 10654697,
    "stId" : "R-XTR-181923-4",
    "displayName" : "LOC100486870 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7C6D9",
    "standardIdentifier" : "uniprot:F7C6D9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC100486870" ],
    "parents" : [ 10654699 ],
    "children" : [ ]
  }, {
    "dbId" : 10654703,
    "stId" : "R-XTR-212293",
    "displayName" : "Ghost homologue of Histone H3 [nucleoplasm]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10654705 ],
    "children" : [ ]
  }, {
    "dbId" : 10654701,
    "stId" : "R-XTR-181911",
    "displayName" : "Histone H2B [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10654705 ],
    "children" : [ 10654699, 10654682 ]
  }, {
    "dbId" : 10654705,
    "stId" : "R-XTR-427402",
    "displayName" : "Nucleosome [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10667396 ],
    "children" : [ 10654701, 10654703, 10654678, 10654630 ]
  }, {
    "dbId" : 10654658,
    "stId" : "R-XTR-181888-6",
    "displayName" : "LOC116411633 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F6XTM2",
    "standardIdentifier" : "uniprot:F6XTM2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC116411633" ],
    "parents" : [ 10654664 ],
    "children" : [ ]
  }, {
    "dbId" : 10698178,
    "stId" : "R-XTR-5578688",
    "displayName" : "AGO1,2:miRNA:chromatin:RNA pol II [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21665 ],
    "parents" : [ ],
    "children" : [ 10667396, 10654881, 10698176 ]
  }, {
    "dbId" : 10673859,
    "stId" : "R-XTR-426510",
    "displayName" : "TNRC6:Nonendonucleolytic RISC:Target RNA (exact match) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21654 ],
    "parents" : [ ],
    "children" : [ 426523, 10673838, 10673850 ]
  }, {
    "dbId" : 10698176,
    "stId" : "R-XTR-5578731",
    "displayName" : "AGO1,2:miRNA [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 21662 ],
    "parents" : [ 10698178 ],
    "children" : [ 10698174, 10698170 ]
  }, {
    "dbId" : 10654662,
    "stId" : "R-XTR-181888-7",
    "displayName" : "h2ax.2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28E74",
    "standardIdentifier" : "uniprot:Q28E74",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "h2ax.2" ],
    "parents" : [ 10654664 ],
    "children" : [ ]
  }, {
    "dbId" : 10654666,
    "stId" : "R-XTR-181890",
    "displayName" : "LOC100487067 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8R705",
    "standardIdentifier" : "uniprot:A0A6I8R705",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC100487067" ],
    "parents" : [ 10654672 ],
    "children" : [ ]
  }, {
    "dbId" : 10654664,
    "stId" : "R-XTR-181888-8",
    "displayName" : "Homologues of HIST1H2AB [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10654678 ],
    "children" : [ 10654654, 10654638, 10654650, 10654662, 10654646, 10654658, 10654642 ]
  }, {
    "dbId" : 10654670,
    "stId" : "R-XTR-181890-3",
    "displayName" : "LOC116407737 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8SFV2",
    "standardIdentifier" : "uniprot:A0A6I8SFV2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC116407737" ],
    "parents" : [ 10654672 ],
    "children" : [ ]
  }, {
    "dbId" : 10654668,
    "stId" : "R-XTR-181890-2",
    "displayName" : "LOC100487632 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8S7P0",
    "standardIdentifier" : "uniprot:A0A6I8S7P0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC100487632" ],
    "parents" : [ 10654672 ],
    "children" : [ ]
  }, {
    "dbId" : 10654672,
    "stId" : "R-XTR-181890-4",
    "displayName" : "Homologues of HIST1H2AJ [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10654678 ],
    "children" : [ 10654668, 10654670, 10654666 ]
  }, {
    "dbId" : 10654678,
    "stId" : "R-XTR-181899",
    "displayName" : "Histone H2A [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10654705 ],
    "children" : [ 10654664, 10654634, 10654676, 10654672 ]
  }, {
    "dbId" : 10654676,
    "stId" : "R-XTR-8862432",
    "displayName" : "LOC100486672 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A803K4P0",
    "standardIdentifier" : "uniprot:A0A803K4P0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC100486672" ],
    "parents" : [ 10654678 ],
    "children" : [ ]
  }, {
    "dbId" : 10654682,
    "stId" : "R-XTR-181898",
    "displayName" : "h2bc11 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28J31",
    "standardIdentifier" : "uniprot:Q28J31",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "h2bc11" ],
    "parents" : [ 10654701, 10654699 ],
    "children" : [ ]
  }, {
    "dbId" : 10654686,
    "stId" : "R-XTR-181923",
    "displayName" : "LOC100498553 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A1B8Y0L0",
    "standardIdentifier" : "uniprot:A0A1B8Y0L0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC100498553" ],
    "parents" : [ 10654699 ],
    "children" : [ ]
  }, {
    "dbId" : 10666303,
    "stId" : "R-XTR-2399897",
    "displayName" : "prkra [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8S266",
    "standardIdentifier" : "uniprot:A0A6I8S266",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "prkra" ],
    "parents" : [ 10688641, 10667193, 10667179, 10688637, 10666327 ],
    "children" : [ ]
  }, {
    "dbId" : 10720514,
    "stId" : "R-XTR-9023915",
    "displayName" : "AGO2:cleaved duplex siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21668 ],
    "parents" : [ ],
    "children" : [ 10666311, 9023914 ]
  }, {
    "dbId" : 10720516,
    "stId" : "R-XTR-5600685",
    "displayName" : "Ghost homologue of TSN [cytosol]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10720522 ],
    "children" : [ ]
  }, {
    "dbId" : 10720522,
    "stId" : "R-XTR-5600681",
    "displayName" : "C3PO [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21671 ],
    "parents" : [ ],
    "children" : [ 10720520, 10720516 ]
  }, {
    "dbId" : 10720520,
    "stId" : "R-XTR-5216130",
    "displayName" : "TSNAX [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6DIG2",
    "standardIdentifier" : "uniprot:Q6DIG2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10720522 ],
    "children" : [ ]
  }, {
    "dbId" : 426446,
    "stId" : "R-ALL-426446",
    "displayName" : "siRNA [cytosol]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "parents" : [ 10673834, 10673836, 10673832, 10673828 ],
    "children" : [ ]
  }, {
    "dbId" : 10688623,
    "stId" : "R-XTR-6789268",
    "displayName" : "PRKRA:DICER1:AGO1,2,3,4:duplex miRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21656 ],
    "parents" : [ ],
    "children" : [ 10667167, 10666327 ]
  }, {
    "dbId" : 10688627,
    "stId" : "R-XTR-2106605",
    "displayName" : "AGO2:duplex siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21667 ],
    "parents" : [ 10688635 ],
    "children" : [ 426472, 10666311 ]
  }, {
    "dbId" : 10653814,
    "stId" : "R-XTR-63531",
    "displayName" : "polr2j [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28CA5",
    "standardIdentifier" : "uniprot:Q28CA5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "polr2j" ],
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10688631,
    "stId" : "R-XTR-2106618",
    "displayName" : "AGO3:duplex siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10688635 ],
    "children" : [ 426472, 10666319 ]
  }, {
    "dbId" : 10688629,
    "stId" : "R-XTR-2106607",
    "displayName" : "AGO1:duplex siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10688635 ],
    "children" : [ 426472, 10666315 ]
  }, {
    "dbId" : 10653818,
    "stId" : "R-XTR-63525",
    "displayName" : "POLR2I [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8QYT9",
    "standardIdentifier" : "uniprot:A0A6I8QYT9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10688635,
    "stId" : "R-XTR-2106630",
    "displayName" : "pre-RISC (siRNA) [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10688637 ],
    "children" : [ 10688627, 10688633, 10688629, 10688631 ]
  }, {
    "dbId" : 426463,
    "stId" : "R-ALL-426463",
    "displayName" : "Double-stranded RNA [cytosol]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "diagramIds" : [ 21640 ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10688633,
    "stId" : "R-XTR-2106600",
    "displayName" : "AGO4:duplex siRNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10688635 ],
    "children" : [ 426472, 10666323 ]
  }, {
    "dbId" : 10653822,
    "stId" : "R-XTR-63504",
    "displayName" : "polr2b [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F6QHD9",
    "standardIdentifier" : "uniprot:F6QHD9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "polr2b" ],
    "parents" : [ 10654881 ],
    "children" : [ ]
  }, {
    "dbId" : 10688639,
    "stId" : "R-XTR-2106611",
    "displayName" : "RISC (siRNA) [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10688641 ],
    "children" : [ 10673828, 10673836, 10673832, 10673834 ]
  }, {
    "dbId" : 10688637,
    "stId" : "R-XTR-6789259",
    "displayName" : "PRKRA:DICER1:Pre-RISC (siRNA) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21658 ],
    "parents" : [ ],
    "children" : [ 10666303, 10688635, 10666307 ]
  }, {
    "dbId" : 10666307,
    "stId" : "R-XTR-203820",
    "displayName" : "DICER1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "B3DLA6",
    "standardIdentifier" : "uniprot:B3DLA6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10688641, 10667193, 10667179, 10688637, 10666327 ],
    "children" : [ ]
  }, {
    "dbId" : 10666311,
    "stId" : "R-XTR-209723",
    "displayName" : "AGO2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q6DJB9",
    "standardIdentifier" : "uniprot:Q6DJB9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10667169, 10667183, 10673828, 10720514, 10688627, 10666325 ],
    "children" : [ ]
  }, {
    "dbId" : 10666315,
    "stId" : "R-XTR-210616",
    "displayName" : "ago1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F6PSN5",
    "standardIdentifier" : "uniprot:F6PSN5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ago1" ],
    "parents" : [ 10673832, 10667185, 10667171, 10688629, 10666325 ],
    "children" : [ ]
  }, {
    "dbId" : 10666319,
    "stId" : "R-XTR-210615",
    "displayName" : "ago3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A8J0QY72",
    "standardIdentifier" : "uniprot:A0A8J0QY72",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ago3" ],
    "parents" : [ 10673834, 10667187, 10667173, 10688631, 10666325 ],
    "children" : [ ]
  }, {
    "dbId" : 426472,
    "stId" : "R-ALL-426472",
    "displayName" : "duplex siRNA [cytosol]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "parents" : [ 10688627, 10673823, 10688633, 10688631, 10688629 ],
    "children" : [ ]
  }, {
    "dbId" : 10666323,
    "stId" : "R-XTR-210612",
    "displayName" : "ago4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A8J0QW37",
    "standardIdentifier" : "uniprot:A0A8J0QW37",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ago4" ],
    "parents" : [ 10673836, 10667189, 10667175, 10688633, 10666325 ],
    "children" : [ ]
  }, {
    "dbId" : 29428,
    "stId" : "R-ALL-29428",
    "displayName" : "DNA [nucleoplasm]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "parents" : [ 10667396 ],
    "children" : [ ]
  }, {
    "dbId" : 10666327,
    "stId" : "R-XTR-6789250",
    "displayName" : "PRKRA:DICER1:AGO1,2,3,4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 21641 ],
    "parents" : [ 10688623, 10673823 ],
    "children" : [ 10666303, 10666325, 10666307 ]
  }, {
    "dbId" : 10666325,
    "stId" : "R-XTR-629636",
    "displayName" : "AGO1,2,3,4 [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 205621,
    "parents" : [ 10666327 ],
    "children" : [ 10666311, 10666319, 10666315, 10666323 ]
  } ],
  "edges" : [ {
    "dbId" : 10673826,
    "stId" : "R-XTR-426464",
    "displayName" : "Dicer cleaves double-stranded RNA to yield double-stranded siRNA",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10673861, 10688645 ],
    "inputs" : [ 426463, 10666327 ],
    "outputs" : [ 10673823 ],
    "catalysts" : [ 10666327 ],
    "efs" : [ ],
    "diagramIds" : [ 21639 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10688643,
    "stId" : "R-XTR-2106615",
    "displayName" : "Removal of siRNA passenger strand",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10688645 ],
    "inputs" : [ 10688637 ],
    "outputs" : [ 10688641 ],
    "efs" : [ ],
    "diagramIds" : [ 21659 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10688625,
    "stId" : "R-XTR-2106614",
    "displayName" : "Duplex miRNA is loaded into Argonaute",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "following" : [ 10667195 ],
    "inputs" : [ 10688623 ],
    "outputs" : [ 10667179 ],
    "efs" : [ ],
    "diagramIds" : [ 21655 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10673857,
    "stId" : "R-XTR-426520",
    "displayName" : "Endonucleolytic RISC hydrolyzes target RNAs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10720525 ],
    "inputs" : [ 426523 ],
    "outputs" : [ 426511 ],
    "catalysts" : [ 10673830 ],
    "efs" : [ ],
    "diagramIds" : [ 21643 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10720528,
    "stId" : "R-XTR-9023912",
    "displayName" : "AGO2 cleaves passenger strand of duplex siRNA",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10688645 ],
    "inputs" : [ 10688627 ],
    "outputs" : [ 10720514 ],
    "catalysts" : [ 10688627 ],
    "efs" : [ ],
    "diagramIds" : [ 21666 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10688645,
    "stId" : "R-XTR-2106625",
    "displayName" : "Duplex siRNA is loaded into Argonaute",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10673826 ],
    "following" : [ 10720528, 10688643, 10720525 ],
    "inputs" : [ 10673823 ],
    "outputs" : [ 10688637 ],
    "efs" : [ ],
    "diagramIds" : [ 21657 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10698180,
    "stId" : "R-XTR-5578742",
    "displayName" : "AGO1,2:small RNA complexes interact with chromatin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10667396, 10654881, 10698176 ],
    "outputs" : [ 10698178 ],
    "efs" : [ ],
    "diagramIds" : [ 21661 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10673861,
    "stId" : "R-XTR-426522",
    "displayName" : "Nonendonucleolytic RISC binds exactly matching target RNAs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10673826 ],
    "inputs" : [ 426523, 10673838, 10673850 ],
    "outputs" : [ 10673859 ],
    "efs" : [ ],
    "diagramIds" : [ 21652 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667195,
    "stId" : "R-XTR-210805",
    "displayName" : "Removal of miRNA passenger strand",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10688625 ],
    "following" : [ 10673854 ],
    "inputs" : [ 10667179 ],
    "outputs" : [ 10667193 ],
    "efs" : [ ],
    "diagramIds" : [ 21636 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10673854,
    "stId" : "R-XTR-426489",
    "displayName" : "RISC binds inexactly matching target RNAs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10720525, 10667195 ],
    "inputs" : [ 10673850, 426515, 10673840 ],
    "outputs" : [ 10673852 ],
    "efs" : [ ],
    "diagramIds" : [ 21647 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10720525,
    "stId" : "R-XTR-9023909",
    "displayName" : "C3PO hydrolyzes cleaved passenger strand",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10688645 ],
    "following" : [ 10673854, 10673857 ],
    "inputs" : [ 10720514 ],
    "outputs" : [ 10673828 ],
    "catalysts" : [ 10720522 ],
    "efs" : [ ],
    "diagramIds" : [ 21669 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10729618,
    "stId" : "R-XTR-203927",
    "displayName" : "MicroRNA (miRNA) biogenesis",
    "events" : [ 10688625, 10667195 ]
  }, {
    "dbId" : 10729948,
    "stId" : "R-XTR-426486",
    "displayName" : "Small interfering RNA (siRNA) biogenesis",
    "events" : [ 10673826, 10688643, 10720528, 10688645, 10720525 ]
  }, {
    "dbId" : 10730752,
    "stId" : "R-XTR-5578749",
    "displayName" : "Transcriptional regulation by small RNAs",
    "events" : [ 10698180 ]
  }, {
    "dbId" : 10729950,
    "stId" : "R-XTR-426496",
    "displayName" : "Post-transcriptional silencing by small RNAs",
    "events" : [ 10673857, 10673861, 10673854 ]
  } ]
}