{
  "dbId" : 10729536,
  "stableId" : "R-XTR-201451",
  "displayName" : "Signaling by BMP",
  "nodes" : [ {
    "id" : 87175,
    "reactomeId" : 10665385,
    "displayName" : "BMP2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 231,
      "y" : 77
    },
    "minX" : 187,
    "maxX" : 282,
    "minY" : 47,
    "maxY" : 134,
    "prop" : {
      "x" : 187,
      "y" : 66,
      "width" : 89,
      "height" : 22
    },
    "textPosition" : {
      "x" : 191,
      "y" : 67
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 276,
          "y" : 66
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 276,
          "y" : 66
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87174,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 238,
          "y" : 63
        },
        "to" : {
          "x" : 251,
          "y" : 47
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87182,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 235,
          "y" : 91
        },
        "to" : {
          "x" : 256,
          "y" : 134
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87177,
    "reactomeId" : 10665734,
    "displayName" : "Ligand Trap:BMP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 370,
      "y" : 47
    },
    "minX" : 327,
    "maxX" : 419,
    "minY" : 23,
    "maxY" : 65,
    "prop" : {
      "x" : 327,
      "y" : 29,
      "width" : 86,
      "height" : 36
    },
    "textPosition" : {
      "x" : 327,
      "y" : 30
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 413,
          "y" : 29
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 413,
          "y" : 29
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87174,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87176,
    "reactomeId" : 10665732,
    "displayName" : "Ligand Trap",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 228,
      "y" : 11
    },
    "minX" : 189,
    "maxX" : 268,
    "minY" : 0,
    "maxY" : 47,
    "prop" : {
      "x" : 189,
      "y" : 0,
      "width" : 79,
      "height" : 22
    },
    "textPosition" : {
      "x" : 202,
      "y" : -6
    },
    "connectors" : [ {
      "edgeId" : 87174,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 235,
          "y" : 28
        },
        "to" : {
          "x" : 251,
          "y" : 47
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87179,
    "reactomeId" : 10665397,
    "displayName" : "BMPRI dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 55,
      "y" : 132
    },
    "minX" : 9,
    "maxX" : 108,
    "minY" : 115,
    "maxY" : 157,
    "prop" : {
      "x" : 9,
      "y" : 121,
      "width" : 93,
      "height" : 23
    },
    "textPosition" : {
      "x" : 13,
      "y" : 123
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 102,
          "y" : 121
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 102,
          "y" : 121
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87178,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 68,
          "y" : 147
        },
        "to" : {
          "x" : 84,
          "y" : 157
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87181,
    "reactomeId" : 10665415,
    "displayName" : "BMPRII:BMPRI",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 179,
      "y" : 134
    },
    "minX" : 145,
    "maxX" : 256,
    "minY" : 110,
    "maxY" : 153,
    "prop" : {
      "x" : 145,
      "y" : 116,
      "width" : 68,
      "height" : 37
    },
    "textPosition" : {
      "x" : 153,
      "y" : 118
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 213,
          "y" : 116
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 213,
          "y" : 116
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87178,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87182,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 216,
          "y" : 134
        },
        "to" : {
          "x" : 256,
          "y" : 134
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87180,
    "reactomeId" : 10665413,
    "displayName" : "BMPRII dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 53,
      "y" : 179
    },
    "minX" : 0,
    "maxX" : 112,
    "minY" : 157,
    "maxY" : 190,
    "prop" : {
      "x" : 0,
      "y" : 169,
      "width" : 106,
      "height" : 21
    },
    "textPosition" : {
      "x" : 9,
      "y" : 169
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 106,
          "y" : 169
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 106,
          "y" : 169
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87178,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 67,
          "y" : 166
        },
        "to" : {
          "x" : 84,
          "y" : 157
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87183,
    "reactomeId" : 10665417,
    "displayName" : "BMP:BMPRII:BMPRI",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 363,
      "y" : 134
    },
    "minX" : 333,
    "maxX" : 456,
    "minY" : 104,
    "maxY" : 159,
    "prop" : {
      "x" : 333,
      "y" : 110,
      "width" : 60,
      "height" : 49
    },
    "textPosition" : {
      "x" : 337,
      "y" : 110
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 393,
          "y" : 110
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 393,
          "y" : 110
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87182,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87185,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 396,
          "y" : 134
        },
        "to" : {
          "x" : 433,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87185,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 396,
          "y" : 123
        },
        "to" : {
          "x" : 451,
          "y" : 104
        }
      }, {
        "from" : {
          "x" : 451,
          "y" : 104
        },
        "to" : {
          "x" : 452,
          "y" : 120
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 452,
          "y" : 124
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 452,
          "y" : 124
        }
      }
    } ]
  }, {
    "id" : 87184,
    "reactomeId" : 10665474,
    "displayName" : "INHIBIN-A:TGFBR3:ACVR2A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 54,
      "y" : 234
    },
    "minX" : 0,
    "maxX" : 302,
    "minY" : 133,
    "maxY" : 253,
    "prop" : {
      "x" : 0,
      "y" : 216,
      "width" : 109,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1,
      "y" : 218
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 109,
          "y" : 216
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 109,
          "y" : 216
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87182,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 101,
          "y" : 213
        },
        "to" : {
          "x" : 301,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 300,
          "y" : 133
        },
        "b" : {
          "x" : 302,
          "y" : 141
        },
        "c" : {
          "x" : 301,
          "y" : 137
        },
        "type" : "STOP",
        "centre" : {
          "x" : 301,
          "y" : 137
        }
      }
    } ]
  }, {
    "id" : 87187,
    "reactomeId" : 10665432,
    "displayName" : "BMP:BMPRII:p-4S-BMPRI",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 637,
      "y" : 136
    },
    "minX" : 223,
    "maxX" : 734,
    "minY" : 112,
    "maxY" : 299,
    "prop" : {
      "x" : 595,
      "y" : 118,
      "width" : 84,
      "height" : 37
    },
    "textPosition" : {
      "x" : 596,
      "y" : 120
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 679,
          "y" : 118
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 679,
          "y" : 118
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87213,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 682,
          "y" : 136
        },
        "to" : {
          "x" : 734,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87185,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 592,
          "y" : 135
        },
        "to" : {
          "x" : 470,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 585,
          "y" : 139
        },
        "b" : {
          "x" : 592,
          "y" : 135
        },
        "c" : {
          "x" : 585,
          "y" : 131
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 585,
          "y" : 131
        }
      }
    }, {
      "edgeId" : 87216,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 614,
          "y" : 158
        },
        "to" : {
          "x" : 521,
          "y" : 233
        }
      }, {
        "from" : {
          "x" : 521,
          "y" : 233
        },
        "to" : {
          "x" : 223,
          "y" : 299
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87189,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 644,
          "y" : 158
        },
        "to" : {
          "x" : 682,
          "y" : 250
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87186,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 405,
      "y" : 195
    },
    "minX" : 387,
    "maxX" : 433,
    "minY" : 135,
    "maxY" : 211,
    "prop" : {
      "x" : 387,
      "y" : 180,
      "width" : 37,
      "height" : 31
    },
    "textPosition" : {
      "x" : 390,
      "y" : 185
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 419,
          "y" : 185
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 419,
          "y" : 185
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87185,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 412,
          "y" : 177
        },
        "to" : {
          "x" : 433,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 8,
        "shape" : {
          "a" : {
            "x" : 416,
            "y" : 150
          },
          "b" : {
            "x" : 428,
            "y" : 162
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 422,
            "y" : 156
          }
        }
      }
    } ]
  }, {
    "id" : 87188,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 506,
      "y" : 195
    },
    "minX" : 470,
    "maxX" : 526,
    "minY" : 135,
    "maxY" : 211,
    "prop" : {
      "x" : 487,
      "y" : 180,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 489,
      "y" : 185
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 520,
          "y" : 185
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 520,
          "y" : 185
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87185,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 496,
          "y" : 177
        },
        "to" : {
          "x" : 470,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 8,
        "shape" : {
          "a" : {
            "x" : 477,
            "y" : 150
          },
          "b" : {
            "x" : 489,
            "y" : 162
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 483,
            "y" : 156
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 489,
          "y" : 173
        },
        "b" : {
          "x" : 496,
          "y" : 177
        },
        "c" : {
          "x" : 496,
          "y" : 169
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 496,
          "y" : 169
        }
      }
    } ]
  }, {
    "id" : 87191,
    "reactomeId" : 10665454,
    "displayName" : "zfyve16",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 633,
      "y" : 240
    },
    "minX" : 603,
    "maxX" : 682,
    "minY" : 223,
    "maxY" : 251,
    "prop" : {
      "x" : 603,
      "y" : 229,
      "width" : 61,
      "height" : 22
    },
    "textPosition" : {
      "x" : 607,
      "y" : 229
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 664,
          "y" : 229
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 664,
          "y" : 229
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87189,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 667,
          "y" : 246
        },
        "to" : {
          "x" : 682,
          "y" : 250
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87190,
    "reactomeId" : 10665441,
    "displayName" : "SMAD1/5/8",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 767,
      "y" : 233
    },
    "minX" : 682,
    "maxX" : 809,
    "minY" : 222,
    "maxY" : 250,
    "prop" : {
      "x" : 725,
      "y" : 222,
      "width" : 84,
      "height" : 22
    },
    "textPosition" : {
      "x" : 729,
      "y" : 222
    },
    "connectors" : [ {
      "edgeId" : 87189,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 719,
          "y" : 241
        },
        "to" : {
          "x" : 682,
          "y" : 250
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87193,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87192,
    "reactomeId" : 10665485,
    "displayName" : "BMP:p-BMPR:Endofin:SMAD1/5/8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 709,
      "y" : 335
    },
    "minX" : 549,
    "maxX" : 759,
    "minY" : 303,
    "maxY" : 366,
    "prop" : {
      "x" : 666,
      "y" : 309,
      "width" : 87,
      "height" : 52
    },
    "textPosition" : {
      "x" : 672,
      "y" : 298
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 753,
          "y" : 309
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 753,
          "y" : 309
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87189,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87195,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 663,
          "y" : 335
        },
        "to" : {
          "x" : 579,
          "y" : 335
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87195,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 663,
          "y" : 343
        },
        "to" : {
          "x" : 553,
          "y" : 366
        }
      }, {
        "from" : {
          "x" : 553,
          "y" : 366
        },
        "to" : {
          "x" : 553,
          "y" : 350
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 553,
          "y" : 346
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 553,
          "y" : 346
        }
      }
    } ]
  }, {
    "id" : 87194,
    "reactomeId" : 10665447,
    "displayName" : "SMURF",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 846,
      "y" : 288
    },
    "minX" : 822,
    "maxX" : 871,
    "minY" : 242,
    "maxY" : 300,
    "prop" : {
      "x" : 822,
      "y" : 277,
      "width" : 49,
      "height" : 23
    },
    "textPosition" : {
      "x" : 825,
      "y" : 271
    },
    "connectors" : [ {
      "edgeId" : 87193,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 846,
          "y" : 271
        },
        "to" : {
          "x" : 846,
          "y" : 250
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 846,
          "y" : 246
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 846,
          "y" : 246
        }
      }
    } ]
  }, {
    "id" : 87197,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 474,
      "y" : 281
    },
    "minX" : 455,
    "maxX" : 520,
    "minY" : 265,
    "maxY" : 334,
    "prop" : {
      "x" : 455,
      "y" : 266,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 457,
      "y" : 271
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 488,
          "y" : 271
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 488,
          "y" : 271
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87195,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 487,
          "y" : 300
        },
        "to" : {
          "x" : 520,
          "y" : 334
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 497,
            "y" : 311
          },
          "b" : {
            "x" : 509,
            "y" : 323
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 503,
            "y" : 317
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 495,
          "y" : 302
        },
        "b" : {
          "x" : 487,
          "y" : 300
        },
        "c" : {
          "x" : 489,
          "y" : 308
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 489,
          "y" : 308
        }
      }
    } ]
  }, {
    "id" : 87196,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 631,
      "y" : 278
    },
    "minX" : 579,
    "maxX" : 651,
    "minY" : 262,
    "maxY" : 335,
    "prop" : {
      "x" : 613,
      "y" : 263,
      "width" : 37,
      "height" : 31
    },
    "textPosition" : {
      "x" : 616,
      "y" : 268
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 645,
          "y" : 268
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 645,
          "y" : 268
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87195,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 616,
          "y" : 297
        },
        "to" : {
          "x" : 579,
          "y" : 335
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 591,
            "y" : 310
          },
          "b" : {
            "x" : 603,
            "y" : 322
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 597,
            "y" : 316
          }
        }
      }
    } ]
  }, {
    "id" : 87198,
    "reactomeId" : 10665456,
    "displayName" : "BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 430,
      "y" : 336
    },
    "minX" : 384,
    "maxX" : 520,
    "minY" : 304,
    "maxY" : 362,
    "prop" : {
      "x" : 384,
      "y" : 310,
      "width" : 92,
      "height" : 52
    },
    "textPosition" : {
      "x" : 384,
      "y" : 313
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 476,
          "y" : 310
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 476,
          "y" : 310
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87195,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 479,
          "y" : 334
        },
        "to" : {
          "x" : 520,
          "y" : 334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 486,
          "y" : 330
        },
        "b" : {
          "x" : 479,
          "y" : 334
        },
        "c" : {
          "x" : 486,
          "y" : 338
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 486,
          "y" : 338
        }
      }
    }, {
      "edgeId" : 87199,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87201,
    "reactomeId" : 10665458,
    "displayName" : "BMP:p-BMPR:Endofin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 511,
      "y" : 438
    },
    "minX" : 430,
    "maxX" : 561,
    "minY" : 411,
    "maxY" : 455,
    "prop" : {
      "x" : 467,
      "y" : 422,
      "width" : 88,
      "height" : 33
    },
    "textPosition" : {
      "x" : 467,
      "y" : 420
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 555,
          "y" : 422
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 555,
          "y" : 422
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87199,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 464,
          "y" : 423
        },
        "to" : {
          "x" : 430,
          "y" : 411
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 456,
          "y" : 424
        },
        "b" : {
          "x" : 464,
          "y" : 423
        },
        "c" : {
          "x" : 459,
          "y" : 417
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 459,
          "y" : 417
        }
      }
    } ]
  }, {
    "id" : 87200,
    "reactomeId" : 10665363,
    "displayName" : "p-2S-SMAD1/5/8",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 372,
      "y" : 435
    },
    "minX" : 235,
    "maxX" : 450,
    "minY" : 411,
    "maxY" : 550,
    "prop" : {
      "x" : 314,
      "y" : 424,
      "width" : 116,
      "height" : 23
    },
    "textPosition" : {
      "x" : 318,
      "y" : 425
    },
    "connectors" : [ {
      "edgeId" : 87202,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 308,
          "y" : 425
        },
        "to" : {
          "x" : 235,
          "y" : 412
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87205,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 379,
          "y" : 453
        },
        "to" : {
          "x" : 450,
          "y" : 550
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 408,
            "y" : 495
          },
          "b" : {
            "x" : 420,
            "y" : 507
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 414,
            "y" : 501
          }
        }
      }
    }, {
      "edgeId" : 87199,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 399,
          "y" : 418
        },
        "to" : {
          "x" : 430,
          "y" : 411
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 405,
          "y" : 413
        },
        "b" : {
          "x" : 399,
          "y" : 418
        },
        "c" : {
          "x" : 407,
          "y" : 420
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 407,
          "y" : 420
        }
      }
    } ]
  }, {
    "id" : 87203,
    "reactomeId" : 10661698,
    "displayName" : "smad7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 282,
      "y" : 361
    },
    "minX" : 223,
    "maxX" : 318,
    "minY" : 299,
    "maxY" : 412,
    "prop" : {
      "x" : 252,
      "y" : 349,
      "width" : 60,
      "height" : 25
    },
    "textPosition" : {
      "x" : 257,
      "y" : 351
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 312,
          "y" : 349
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 312,
          "y" : 349
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87202,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 270,
          "y" : 380
        },
        "to" : {
          "x" : 235,
          "y" : 412
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87216,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 270,
          "y" : 343
        },
        "to" : {
          "x" : 223,
          "y" : 299
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87204,
    "reactomeId" : 10666069,
    "displayName" : "I-SMAD:p-2S-SMAD1/5/8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 115,
      "y" : 416
    },
    "minX" : 65,
    "maxX" : 171,
    "minY" : 389,
    "maxY" : 437,
    "prop" : {
      "x" : 65,
      "y" : 395,
      "width" : 100,
      "height" : 42
    },
    "textPosition" : {
      "x" : 72,
      "y" : 402
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 165,
          "y" : 395
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 165,
          "y" : 395
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87202,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87207,
    "reactomeId" : 10665365,
    "displayName" : "p-2S-SMAD1/5/8:SMAD4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 568,
      "y" : 548
    },
    "minX" : 508,
    "maxX" : 635,
    "minY" : 523,
    "maxY" : 568,
    "prop" : {
      "x" : 508,
      "y" : 529,
      "width" : 121,
      "height" : 39
    },
    "textPosition" : {
      "x" : 513,
      "y" : 533
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 629,
          "y" : 529
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 629,
          "y" : 529
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87205,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87208,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87206,
    "reactomeId" : 10661574,
    "displayName" : "smad4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 414,
      "y" : 580
    },
    "minX" : 382,
    "maxX" : 452,
    "minY" : 550,
    "maxY" : 591,
    "prop" : {
      "x" : 382,
      "y" : 569,
      "width" : 64,
      "height" : 22
    },
    "textPosition" : {
      "x" : 389,
      "y" : 569
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 446,
          "y" : 569
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 446,
          "y" : 569
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87205,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 427,
          "y" : 566
        },
        "to" : {
          "x" : 450,
          "y" : 550
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87209,
    "reactomeId" : 10665375,
    "displayName" : "p-2S-SMAD1/5/8:SMAD4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 805,
      "y" : 549
    },
    "minX" : 744,
    "maxX" : 873,
    "minY" : 524,
    "maxY" : 585,
    "prop" : {
      "x" : 744,
      "y" : 530,
      "width" : 123,
      "height" : 38
    },
    "textPosition" : {
      "x" : 750,
      "y" : 533
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 867,
          "y" : 530
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 867,
          "y" : 530
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87208,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87210,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 836,
          "y" : 571
        },
        "to" : {
          "x" : 864,
          "y" : 585
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87211,
    "reactomeId" : 10661684,
    "displayName" : "ski",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 790,
      "y" : 601
    },
    "minX" : 773,
    "maxX" : 864,
    "minY" : 583,
    "maxY" : 613,
    "prop" : {
      "x" : 773,
      "y" : 589,
      "width" : 35,
      "height" : 24
    },
    "textPosition" : {
      "x" : 778,
      "y" : 590
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 808,
          "y" : 589
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 808,
          "y" : 589
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87210,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 811,
          "y" : 597
        },
        "to" : {
          "x" : 864,
          "y" : 585
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87212,
    "reactomeId" : 10665377,
    "displayName" : "p-2S-SMAD1/5/8:SMAD4:SKI",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1020,
      "y" : 588
    },
    "minX" : 958,
    "maxX" : 1088,
    "minY" : 565,
    "maxY" : 606,
    "prop" : {
      "x" : 958,
      "y" : 571,
      "width" : 124,
      "height" : 35
    },
    "textPosition" : {
      "x" : 964,
      "y" : 571
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1082,
          "y" : 571
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1082,
          "y" : 571
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87210,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87215,
    "reactomeId" : 10665740,
    "displayName" : "BMP:p-BMPR:I-SMAD:SMURF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 859,
      "y" : 136
    },
    "minX" : 802,
    "maxX" : 922,
    "minY" : 112,
    "maxY" : 155,
    "prop" : {
      "x" : 802,
      "y" : 118,
      "width" : 114,
      "height" : 37
    },
    "textPosition" : {
      "x" : 811,
      "y" : 120
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 916,
          "y" : 118
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 916,
          "y" : 118
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87213,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87214,
    "reactomeId" : 10665738,
    "displayName" : "I-SMAD:SMURF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 715,
      "y" : 179
    },
    "minX" : 686,
    "maxX" : 750,
    "minY" : 136,
    "maxY" : 198,
    "prop" : {
      "x" : 686,
      "y" : 160,
      "width" : 58,
      "height" : 38
    },
    "textPosition" : {
      "x" : 688,
      "y" : 163
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 744,
          "y" : 160
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 744,
          "y" : 160
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87213,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 723,
          "y" : 157
        },
        "to" : {
          "x" : 734,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87217,
    "reactomeId" : 10665481,
    "displayName" : "BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 65,
      "y" : 301
    },
    "minX" : 4,
    "maxX" : 133,
    "minY" : 260,
    "maxY" : 337,
    "prop" : {
      "x" : 4,
      "y" : 266,
      "width" : 123,
      "height" : 71
    },
    "textPosition" : {
      "x" : 7,
      "y" : 260
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 127,
          "y" : 266
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 127,
          "y" : 266
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87216,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87219,
    "reactomeId" : 10713501,
    "displayName" : "GDF2 dimer, BMP10 dimer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1226,
      "y" : 51
    },
    "minX" : 1182,
    "maxX" : 1270,
    "minY" : 33,
    "maxY" : 92,
    "prop" : {
      "x" : 1182,
      "y" : 33,
      "width" : 88,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1182,
      "y" : 27
    },
    "connectors" : [ {
      "edgeId" : 87218,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1240,
          "y" : 75
        },
        "to" : {
          "x" : 1260,
          "y" : 92
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87221,
    "reactomeId" : 10713503,
    "displayName" : "ACVRL1:GDF2 dimer, BMP10 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1369,
      "y" : 135
    },
    "minX" : 1301,
    "maxX" : 1444,
    "minY" : 112,
    "maxY" : 153,
    "prop" : {
      "x" : 1301,
      "y" : 118,
      "width" : 137,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1301,
      "y" : 118
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1438,
          "y" : 118
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1438,
          "y" : 118
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87218,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87220,
    "reactomeId" : 10713487,
    "displayName" : "ACVRL1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1240,
      "y" : 135
    },
    "minX" : 1208,
    "maxX" : 1278,
    "minY" : 92,
    "maxY" : 149,
    "prop" : {
      "x" : 1208,
      "y" : 122,
      "width" : 64,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1213,
      "y" : 125
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1272,
          "y" : 122
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1272,
          "y" : 122
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87218,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1246,
          "y" : 119
        },
        "to" : {
          "x" : 1260,
          "y" : 92
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 87202,
    "reactomeId" : 10666071,
    "displayName" : "I-Smad competes with Co-Smad for R-Smad1/5/8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 194,
      "y" : 413
    },
    "minX" : 168,
    "maxX" : 235,
    "minY" : 407,
    "maxY" : 419,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 235,
        "y" : 412
      },
      "to" : {
        "x" : 194,
        "y" : 413
      }
    }, {
      "from" : {
        "x" : 194,
        "y" : 413
      },
      "to" : {
        "x" : 168,
        "y" : 414
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 175,
        "y" : 410
      },
      "b" : {
        "x" : 168,
        "y" : 414
      },
      "c" : {
        "x" : 175,
        "y" : 418
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 175,
        "y" : 418
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 194,
        "y" : 413
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 194,
        "y" : 413
      }
    },
    "inputs" : [ {
      "id" : 87200,
      "points" : [ {
        "x" : 308,
        "y" : 425
      } ]
    }, {
      "id" : 87203,
      "points" : [ {
        "x" : 270,
        "y" : 380
      } ]
    } ],
    "outputs" : [ {
      "id" : 87204
    } ]
  }, {
    "id" : 87205,
    "reactomeId" : 10665367,
    "displayName" : "Phospho-R-Smad1/5/8 forms a complex with Co-Smad",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 474,
      "y" : 549
    },
    "minX" : 450,
    "maxX" : 505,
    "minY" : 543,
    "maxY" : 555,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 450,
        "y" : 550
      },
      "to" : {
        "x" : 474,
        "y" : 549
      }
    }, {
      "from" : {
        "x" : 474,
        "y" : 549
      },
      "to" : {
        "x" : 505,
        "y" : 548
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 498,
        "y" : 552
      },
      "b" : {
        "x" : 505,
        "y" : 548
      },
      "c" : {
        "x" : 498,
        "y" : 544
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 498,
        "y" : 544
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 474,
        "y" : 549
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 474,
        "y" : 549
      }
    },
    "inputs" : [ {
      "id" : 87206,
      "points" : [ {
        "x" : 427,
        "y" : 566
      } ]
    }, {
      "id" : 87200,
      "points" : [ {
        "x" : 379,
        "y" : 453
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 87207
    } ]
  }, {
    "id" : 87174,
    "reactomeId" : 10665736,
    "displayName" : "The ligand trap binds the ligand BMP2, blocking BMP signalling",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 279,
      "y" : 46
    },
    "minX" : 251,
    "maxX" : 324,
    "minY" : 40,
    "maxY" : 52,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 251,
        "y" : 47
      },
      "to" : {
        "x" : 279,
        "y" : 46
      }
    }, {
      "from" : {
        "x" : 279,
        "y" : 46
      },
      "to" : {
        "x" : 324,
        "y" : 46
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 317,
        "y" : 50
      },
      "b" : {
        "x" : 324,
        "y" : 46
      },
      "c" : {
        "x" : 317,
        "y" : 42
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 317,
        "y" : 42
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 279,
        "y" : 46
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 279,
        "y" : 46
      }
    },
    "inputs" : [ {
      "id" : 87175,
      "points" : [ {
        "x" : 238,
        "y" : 63
      } ]
    }, {
      "id" : 87176,
      "points" : [ {
        "x" : 235,
        "y" : 28
      } ]
    } ],
    "outputs" : [ {
      "id" : 87177
    } ]
  }, {
    "id" : 87208,
    "reactomeId" : 10665479,
    "displayName" : "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 682,
      "y" : 546
    },
    "minX" : 632,
    "maxX" : 741,
    "minY" : 540,
    "maxY" : 552,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 632,
        "y" : 546
      },
      "to" : {
        "x" : 682,
        "y" : 546
      }
    }, {
      "from" : {
        "x" : 682,
        "y" : 546
      },
      "to" : {
        "x" : 741,
        "y" : 547
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 734,
        "y" : 551
      },
      "b" : {
        "x" : 741,
        "y" : 547
      },
      "c" : {
        "x" : 734,
        "y" : 543
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 734,
        "y" : 543
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 676,
        "y" : 540
      },
      "b" : {
        "x" : 688,
        "y" : 552
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 682,
        "y" : 546
      }
    },
    "inputs" : [ {
      "id" : 87207
    } ],
    "outputs" : [ {
      "id" : 87209
    } ]
  }, {
    "id" : 87210,
    "reactomeId" : 10665379,
    "displayName" : "SKI complexes with the Smad complex, suppressing BMP2 signalling",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 902,
      "y" : 584
    },
    "minX" : 864,
    "maxX" : 955,
    "minY" : 578,
    "maxY" : 590,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 864,
        "y" : 585
      },
      "to" : {
        "x" : 902,
        "y" : 584
      }
    }, {
      "from" : {
        "x" : 902,
        "y" : 584
      },
      "to" : {
        "x" : 955,
        "y" : 585
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 948,
        "y" : 589
      },
      "b" : {
        "x" : 955,
        "y" : 585
      },
      "c" : {
        "x" : 948,
        "y" : 581
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 948,
        "y" : 581
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 902,
        "y" : 584
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 902,
        "y" : 584
      }
    },
    "inputs" : [ {
      "id" : 87209,
      "points" : [ {
        "x" : 836,
        "y" : 571
      } ]
    }, {
      "id" : 87211,
      "points" : [ {
        "x" : 811,
        "y" : 597
      } ]
    } ],
    "outputs" : [ {
      "id" : 87212
    } ]
  }, {
    "id" : 87178,
    "reactomeId" : 10666067,
    "displayName" : "Formation of a heteromeric BMP receptor complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 119,
      "y" : 157
    },
    "minX" : 84,
    "maxX" : 142,
    "minY" : 147,
    "maxY" : 163,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 84,
        "y" : 157
      },
      "to" : {
        "x" : 119,
        "y" : 157
      }
    }, {
      "from" : {
        "x" : 119,
        "y" : 157
      },
      "to" : {
        "x" : 142,
        "y" : 147
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 137,
        "y" : 153
      },
      "b" : {
        "x" : 142,
        "y" : 147
      },
      "c" : {
        "x" : 134,
        "y" : 146
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 134,
        "y" : 146
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 119,
        "y" : 157
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 119,
        "y" : 157
      }
    },
    "inputs" : [ {
      "id" : 87179,
      "points" : [ {
        "x" : 68,
        "y" : 147
      } ]
    }, {
      "id" : 87180,
      "points" : [ {
        "x" : 67,
        "y" : 166
      } ]
    } ],
    "outputs" : [ {
      "id" : 87181
    } ]
  }, {
    "id" : 87213,
    "reactomeId" : 10665742,
    "displayName" : "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 767,
      "y" : 136
    },
    "minX" : 734,
    "maxX" : 799,
    "minY" : 130,
    "maxY" : 142,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 734,
        "y" : 136
      },
      "to" : {
        "x" : 767,
        "y" : 136
      }
    }, {
      "from" : {
        "x" : 767,
        "y" : 136
      },
      "to" : {
        "x" : 799,
        "y" : 136
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 792,
        "y" : 140
      },
      "b" : {
        "x" : 799,
        "y" : 136
      },
      "c" : {
        "x" : 792,
        "y" : 132
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 792,
        "y" : 132
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 767,
        "y" : 136
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 767,
        "y" : 136
      }
    },
    "inputs" : [ {
      "id" : 87214,
      "points" : [ {
        "x" : 723,
        "y" : 157
      } ]
    }, {
      "id" : 87187,
      "points" : [ {
        "x" : 682,
        "y" : 136
      } ]
    } ],
    "outputs" : [ {
      "id" : 87215
    } ]
  }, {
    "id" : 87182,
    "reactomeId" : 10665476,
    "displayName" : "BMP2 binds to the receptor complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 309,
      "y" : 134
    },
    "minX" : 256,
    "maxX" : 330,
    "minY" : 128,
    "maxY" : 140,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 256,
        "y" : 134
      },
      "to" : {
        "x" : 309,
        "y" : 134
      }
    }, {
      "from" : {
        "x" : 309,
        "y" : 134
      },
      "to" : {
        "x" : 330,
        "y" : 134
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 323,
        "y" : 138
      },
      "b" : {
        "x" : 330,
        "y" : 134
      },
      "c" : {
        "x" : 323,
        "y" : 130
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 323,
        "y" : 130
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 309,
        "y" : 134
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 309,
        "y" : 134
      }
    },
    "inputs" : [ {
      "id" : 87181,
      "points" : [ {
        "x" : 216,
        "y" : 134
      } ]
    }, {
      "id" : 87175,
      "points" : [ {
        "x" : 235,
        "y" : 91
      } ]
    } ],
    "outputs" : [ {
      "id" : 87183
    } ],
    "inhibitors" : [ {
      "id" : 87184,
      "points" : [ {
        "x" : 101,
        "y" : 213
      } ]
    } ]
  }, {
    "id" : 87185,
    "reactomeId" : 10665435,
    "displayName" : "Type II receptor phosphorylates type I receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 452,
      "y" : 136
    },
    "minX" : 433,
    "maxX" : 470,
    "minY" : 130,
    "maxY" : 142,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 433,
        "y" : 135
      },
      "to" : {
        "x" : 452,
        "y" : 136
      }
    }, {
      "from" : {
        "x" : 452,
        "y" : 136
      },
      "to" : {
        "x" : 470,
        "y" : 135
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 446,
        "y" : 130
      },
      "b" : {
        "x" : 458,
        "y" : 142
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 452,
        "y" : 136
      }
    },
    "inputs" : [ {
      "id" : 87186,
      "points" : [ {
        "x" : 412,
        "y" : 177
      } ],
      "stoichiometry" : 8
    }, {
      "id" : 87183,
      "points" : [ {
        "x" : 396,
        "y" : 134
      } ]
    } ],
    "outputs" : [ {
      "id" : 87187,
      "points" : [ {
        "x" : 592,
        "y" : 135
      } ]
    }, {
      "id" : 87188,
      "points" : [ {
        "x" : 496,
        "y" : 177
      } ],
      "stoichiometry" : 8
    } ],
    "catalysts" : [ {
      "id" : 87183,
      "points" : [ {
        "x" : 396,
        "y" : 123
      }, {
        "x" : 451,
        "y" : 104
      } ]
    } ]
  }, {
    "id" : 87216,
    "reactomeId" : 10665483,
    "displayName" : "I-Smad competes with R-Smad1/5/8 for type I receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 187,
      "y" : 299
    },
    "minX" : 130,
    "maxX" : 223,
    "minY" : 293,
    "maxY" : 305,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 223,
        "y" : 299
      },
      "to" : {
        "x" : 187,
        "y" : 299
      }
    }, {
      "from" : {
        "x" : 187,
        "y" : 299
      },
      "to" : {
        "x" : 130,
        "y" : 299
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 137,
        "y" : 295
      },
      "b" : {
        "x" : 130,
        "y" : 299
      },
      "c" : {
        "x" : 137,
        "y" : 303
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 137,
        "y" : 303
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 187,
        "y" : 299
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 187,
        "y" : 299
      }
    },
    "inputs" : [ {
      "id" : 87187,
      "points" : [ {
        "x" : 614,
        "y" : 158
      }, {
        "x" : 521,
        "y" : 233
      } ]
    }, {
      "id" : 87203,
      "points" : [ {
        "x" : 270,
        "y" : 343
      } ]
    } ],
    "outputs" : [ {
      "id" : 87217
    } ]
  }, {
    "id" : 87218,
    "reactomeId" : 10713505,
    "displayName" : "ACVRL1 binds BMP9,BMP10",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1286,
      "y" : 93
    },
    "minX" : 1260,
    "maxX" : 1334,
    "minY" : 87,
    "maxY" : 115,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1260,
        "y" : 92
      },
      "to" : {
        "x" : 1286,
        "y" : 93
      }
    }, {
      "from" : {
        "x" : 1286,
        "y" : 93
      },
      "to" : {
        "x" : 1334,
        "y" : 115
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1326,
        "y" : 116
      },
      "b" : {
        "x" : 1334,
        "y" : 115
      },
      "c" : {
        "x" : 1329,
        "y" : 108
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1329,
        "y" : 108
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1286,
        "y" : 93
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1286,
        "y" : 93
      }
    },
    "inputs" : [ {
      "id" : 87219,
      "points" : [ {
        "x" : 1240,
        "y" : 75
      } ]
    }, {
      "id" : 87220,
      "points" : [ {
        "x" : 1246,
        "y" : 119
      } ]
    } ],
    "outputs" : [ {
      "id" : 87221
    } ]
  }, {
    "id" : 87189,
    "reactomeId" : 10665621,
    "displayName" : "An anchoring protein, Endofin, recruits R-Smad1/5/8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 693,
      "y" : 279
    },
    "minX" : 682,
    "maxX" : 701,
    "minY" : 250,
    "maxY" : 306,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 682,
        "y" : 250
      },
      "to" : {
        "x" : 693,
        "y" : 279
      }
    }, {
      "from" : {
        "x" : 693,
        "y" : 279
      },
      "to" : {
        "x" : 701,
        "y" : 306
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 695,
        "y" : 300
      },
      "b" : {
        "x" : 701,
        "y" : 306
      },
      "c" : {
        "x" : 703,
        "y" : 298
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 703,
        "y" : 298
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 693,
        "y" : 279
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 693,
        "y" : 279
      }
    },
    "inputs" : [ {
      "id" : 87190,
      "points" : [ {
        "x" : 719,
        "y" : 241
      } ]
    }, {
      "id" : 87187,
      "points" : [ {
        "x" : 644,
        "y" : 158
      } ]
    }, {
      "id" : 87191,
      "points" : [ {
        "x" : 667,
        "y" : 246
      } ]
    } ],
    "outputs" : [ {
      "id" : 87192
    } ]
  }, {
    "id" : 87193,
    "reactomeId" : 10665450,
    "displayName" : "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 846,
      "y" : 234
    },
    "minX" : 815,
    "maxX" : 888,
    "minY" : 228,
    "maxY" : 240,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 815,
        "y" : 233
      },
      "to" : {
        "x" : 846,
        "y" : 234
      }
    }, {
      "from" : {
        "x" : 846,
        "y" : 234
      },
      "to" : {
        "x" : 888,
        "y" : 235
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 840,
        "y" : 228
      },
      "b" : {
        "x" : 852,
        "y" : 240
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 846,
        "y" : 234
      }
    },
    "inputs" : [ {
      "id" : 87190
    } ],
    "catalysts" : [ {
      "id" : 87194,
      "points" : [ {
        "x" : 846,
        "y" : 271
      } ]
    } ]
  }, {
    "id" : 87195,
    "reactomeId" : 10665488,
    "displayName" : "Activated type I receptor phosphorylates R-Smad1/5/8 directly",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 553,
      "y" : 334
    },
    "minX" : 520,
    "maxX" : 579,
    "minY" : 328,
    "maxY" : 340,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 579,
        "y" : 335
      },
      "to" : {
        "x" : 553,
        "y" : 334
      }
    }, {
      "from" : {
        "x" : 553,
        "y" : 334
      },
      "to" : {
        "x" : 520,
        "y" : 334
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 547,
        "y" : 328
      },
      "b" : {
        "x" : 559,
        "y" : 340
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 553,
        "y" : 334
      }
    },
    "inputs" : [ {
      "id" : 87192,
      "points" : [ {
        "x" : 663,
        "y" : 335
      } ]
    }, {
      "id" : 87196,
      "points" : [ {
        "x" : 616,
        "y" : 297
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 87197,
      "points" : [ {
        "x" : 487,
        "y" : 300
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 87198,
      "points" : [ {
        "x" : 479,
        "y" : 334
      } ]
    } ],
    "catalysts" : [ {
      "id" : 87192,
      "points" : [ {
        "x" : 663,
        "y" : 343
      }, {
        "x" : 553,
        "y" : 366
      } ]
    } ]
  }, {
    "id" : 87199,
    "reactomeId" : 10665460,
    "displayName" : "Phospho-R-Smad1/5/8 dissociates from the receptor complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 431,
      "y" : 390
    },
    "minX" : 425,
    "maxX" : 437,
    "minY" : 365,
    "maxY" : 411,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 430,
        "y" : 365
      },
      "to" : {
        "x" : 431,
        "y" : 390
      }
    }, {
      "from" : {
        "x" : 431,
        "y" : 390
      },
      "to" : {
        "x" : 430,
        "y" : 411
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 431,
        "y" : 390
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 431,
        "y" : 390
      }
    },
    "inputs" : [ {
      "id" : 87198
    } ],
    "outputs" : [ {
      "id" : 87200,
      "points" : [ {
        "x" : 399,
        "y" : 418
      } ]
    }, {
      "id" : 87201,
      "points" : [ {
        "x" : 464,
        "y" : 423
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 87223,
    "reactomeId" : 17941,
    "displayName" : "early endosome",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 567,
      "y" : 385
    },
    "minX" : 370,
    "maxX" : 765,
    "minY" : 329,
    "maxY" : 442,
    "prop" : {
      "x" : 370,
      "y" : 329,
      "width" : 395,
      "height" : 113
    },
    "textPosition" : {
      "x" : 613,
      "y" : 391
    },
    "insets" : {
      "x" : 380,
      "y" : 339,
      "width" : 375,
      "height" : 93
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 87198, 87201, 87199, 87200, 87192, 87195 ]
  }, {
    "id" : 87222,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 739,
      "y" : 436
    },
    "minX" : 34,
    "maxX" : 1445,
    "minY" : 129,
    "maxY" : 743,
    "prop" : {
      "x" : 34,
      "y" : 129,
      "width" : 1411,
      "height" : 614
    },
    "textPosition" : {
      "x" : 1345,
      "y" : 684
    },
    "insets" : {
      "x" : 44,
      "y" : 139,
      "width" : 1391,
      "height" : 594
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 87223, 87224, 87178, 87179, 87180, 87181, 87183, 87187, 87188, 87186, 87185, 87190, 87193, 87194, 87196, 87197, 87204, 87203, 87202, 87205, 87206, 87207, 87215, 87214, 87213, 87216, 87217, 87191, 87189, 87220, 87221, 87182, 87184 ]
  }, {
    "id" : 87224,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 899,
      "y" : 565
    },
    "minX" : 647,
    "maxX" : 1152,
    "minY" : 458,
    "maxY" : 672,
    "prop" : {
      "x" : 647,
      "y" : 458,
      "width" : 505,
      "height" : 214
    },
    "textPosition" : {
      "x" : 663,
      "y" : 625
    },
    "insets" : {
      "x" : 657,
      "y" : 468,
      "width" : 485,
      "height" : 194
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 87209, 87208, 87212, 87210, 87211, 87225 ]
  } ],
  "notes" : [ {
    "id" : 87225,
    "displayName" : "Gene expression regulation",
    "renderableClass" : "Note",
    "position" : {
      "x" : 956,
      "y" : 635
    },
    "minX" : 867,
    "maxX" : 1045,
    "minY" : 618,
    "maxY" : 653,
    "prop" : {
      "x" : 867,
      "y" : 618,
      "width" : 178,
      "height" : 35
    },
    "textPosition" : {
      "x" : 897,
      "y" : 618
    }
  } ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1445,
  "minY" : 0,
  "maxY" : 743,
  "disease" : false
}