{
  "dbId" : 10729160,
  "stableId" : "R-XTR-166166",
  "displayName" : "MyD88-independent TLR4 cascade ",
  "nodes" : [ {
    "id" : 130595,
    "reactomeId" : 10676166,
    "displayName" : "K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 304,
      "y" : 1052
    },
    "minX" : 241,
    "maxX" : 373,
    "minY" : 1021,
    "maxY" : 1078,
    "prop" : {
      "x" : 241,
      "y" : 1027,
      "width" : 126,
      "height" : 51
    },
    "textPosition" : {
      "x" : 244,
      "y" : 1029
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 367,
          "y" : 1027
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 367,
          "y" : 1027
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 130613,
    "reactomeId" : 10728888,
    "displayName" : "Apoptosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 100,
      "y" : 799
    },
    "minX" : 54,
    "maxX" : 147,
    "minY" : 781,
    "maxY" : 818,
    "prop" : {
      "x" : 54,
      "y" : 781,
      "width" : 93,
      "height" : 37
    },
    "textPosition" : {
      "x" : 61,
      "y" : 785
    },
    "connectors" : [ ]
  }, {
    "id" : 130614,
    "reactomeId" : 10728898,
    "displayName" : "Regulated Necrosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 123,
      "y" : 401
    },
    "minX" : 79,
    "maxX" : 167,
    "minY" : 379,
    "maxY" : 424,
    "prop" : {
      "x" : 79,
      "y" : 379,
      "width" : 88,
      "height" : 45
    },
    "textPosition" : {
      "x" : 81,
      "y" : 380
    },
    "connectors" : [ ]
  }, {
    "id" : 130603,
    "reactomeId" : 10729154,
    "displayName" : "MAP kinase activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 395,
      "y" : 1144
    },
    "minX" : 352,
    "maxX" : 439,
    "minY" : 1122,
    "maxY" : 1167,
    "prop" : {
      "x" : 352,
      "y" : 1122,
      "width" : 87,
      "height" : 45
    },
    "textPosition" : {
      "x" : 350,
      "y" : 1123
    },
    "connectors" : [ ]
  }, {
    "id" : 130587,
    "reactomeId" : 10661165,
    "displayName" : "phospho-irf7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1693,
      "y" : 929
    },
    "minX" : 1631,
    "maxX" : 1762,
    "minY" : 905,
    "maxY" : 979,
    "prop" : {
      "x" : 1631,
      "y" : 911,
      "width" : 125,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1650,
      "y" : 919
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1756,
          "y" : 911
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1756,
          "y" : 911
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 130586,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1687,
            "y" : 967
          },
          "b" : {
            "x" : 1699,
            "y" : 979
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1693,
            "y" : 973
          }
        }
      }
    } ]
  }, {
    "id" : 130604,
    "reactomeId" : 10730758,
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 232,
      "y" : 1154
    },
    "minX" : 165,
    "maxX" : 299,
    "minY" : 1125,
    "maxY" : 1184,
    "prop" : {
      "x" : 165,
      "y" : 1125,
      "width" : 134,
      "height" : 59
    },
    "textPosition" : {
      "x" : 168,
      "y" : 1126
    },
    "connectors" : [ ]
  }, {
    "id" : 130588,
    "reactomeId" : 10661167,
    "displayName" : "p-2S-IRF7:p-2S-IRF7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1669,
      "y" : 1037
    },
    "minX" : 1603,
    "maxX" : 1741,
    "minY" : 1013,
    "maxY" : 1056,
    "prop" : {
      "x" : 1603,
      "y" : 1019,
      "width" : 132,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1605,
      "y" : 1027
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1735,
          "y" : 1019
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1735,
          "y" : 1019
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 130586,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 130589,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 130590,
    "reactomeId" : 10662524,
    "displayName" : "2xp-S477,S479-IRF7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1665,
      "y" : 1138
    },
    "minX" : 1599,
    "maxX" : 1737,
    "minY" : 1114,
    "maxY" : 1157,
    "prop" : {
      "x" : 1599,
      "y" : 1120,
      "width" : 132,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1599,
      "y" : 1128
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1731,
          "y" : 1120
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1731,
          "y" : 1120
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 130589,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 130586,
    "reactomeId" : 10661169,
    "displayName" : "Dimerization of phosphorylated IRF3/IRF7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1693,
      "y" : 992
    },
    "minX" : 1678,
    "maxX" : 1699,
    "minY" : 954,
    "maxY" : 1013,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1693,
        "y" : 954
      },
      "to" : {
        "x" : 1693,
        "y" : 992
      }
    }, {
      "from" : {
        "x" : 1693,
        "y" : 992
      },
      "to" : {
        "x" : 1678,
        "y" : 1013
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1679,
        "y" : 1005
      },
      "b" : {
        "x" : 1678,
        "y" : 1013
      },
      "c" : {
        "x" : 1685,
        "y" : 1010
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1685,
        "y" : 1010
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1693,
        "y" : 992
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1693,
        "y" : 992
      }
    },
    "inputs" : [ {
      "id" : 130587,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 130588
    } ]
  }, {
    "id" : 130589,
    "reactomeId" : 10662526,
    "displayName" : "Dimerized phospho-IRF3/IRF7 is transported to the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1668,
      "y" : 1075
    },
    "minX" : 1662,
    "maxX" : 1674,
    "minY" : 1062,
    "maxY" : 1114,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1668,
        "y" : 1062
      },
      "to" : {
        "x" : 1668,
        "y" : 1075
      }
    }, {
      "from" : {
        "x" : 1668,
        "y" : 1075
      },
      "to" : {
        "x" : 1665,
        "y" : 1114
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1662,
        "y" : 1107
      },
      "b" : {
        "x" : 1665,
        "y" : 1114
      },
      "c" : {
        "x" : 1670,
        "y" : 1107
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1670,
        "y" : 1107
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1662,
        "y" : 1069
      },
      "b" : {
        "x" : 1674,
        "y" : 1081
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1668,
        "y" : 1075
      }
    },
    "inputs" : [ {
      "id" : 130588
    } ],
    "outputs" : [ {
      "id" : 130590
    } ]
  } ],
  "compartments" : [ {
    "id" : 130593,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1665,
      "y" : 1140
    },
    "minX" : 1565,
    "maxX" : 1765,
    "minY" : 1070,
    "maxY" : 1211,
    "prop" : {
      "x" : 1565,
      "y" : 1070,
      "width" : 200,
      "height" : 141
    },
    "textPosition" : {
      "x" : 1577,
      "y" : 1080
    },
    "insets" : {
      "x" : 1575,
      "y" : 1080,
      "width" : 180,
      "height" : 121
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130589, 130590, 130589, 130590, 130590, 130590, 130589, 130589 ]
  }, {
    "id" : 130591,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 893,
      "y" : 618
    },
    "minX" : 0,
    "maxX" : 1787,
    "minY" : 0,
    "maxY" : 1237,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1787,
      "height" : 1237
    },
    "textPosition" : {
      "x" : 24,
      "y" : 36
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1767,
      "height" : 1217
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 130606, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130593, 130590, 130587, 130586, 130589, 130589, 130589, 130589, 130589, 130589, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130588, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130603, 130604, 130624, 130625, 130626, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130589, 130590, 130590, 130590, 130590, 130590, 130589, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130589, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130589, 130590, 130589, 130590, 130590, 130590, 130590, 130590, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130590, 130590, 130589, 130590, 130590, 130589, 130590, 130589, 130589, 130590, 130589, 130590, 130590, 130613, 130630, 130614, 130629, 130628 ]
  }, {
    "id" : 130606,
    "reactomeId" : 171907,
    "displayName" : "endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 840,
      "y" : 614
    },
    "minX" : 185,
    "maxX" : 1496,
    "minY" : 178,
    "maxY" : 1050,
    "prop" : {
      "x" : 185,
      "y" : 178,
      "width" : 1311,
      "height" : 872
    },
    "textPosition" : {
      "x" : 320,
      "y" : 268
    },
    "insets" : {
      "x" : 195,
      "y" : 188,
      "width" : 1291,
      "height" : 852
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 130595, 130627 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 130625,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 269,
      "y" : 1101
    },
    "minX" : 253,
    "maxX" : 285,
    "minY" : 1081,
    "maxY" : 1122,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 285,
        "y" : 1081
      },
      "to" : {
        "x" : 253,
        "y" : 1122
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 254,
        "y" : 1114
      },
      "b" : {
        "x" : 253,
        "y" : 1122
      },
      "c" : {
        "x" : 260,
        "y" : 1119
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 260,
        "y" : 1119
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 263,
        "y" : 1095
      },
      "b" : {
        "x" : 275,
        "y" : 1107
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 269,
        "y" : 1101
      }
    },
    "inputs" : [ {
      "id" : 130595
    } ],
    "outputs" : [ {
      "id" : 130604
    } ]
  }, {
    "id" : 130624,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 350,
      "y" : 1100
    },
    "minX" : 329,
    "maxX" : 371,
    "minY" : 1081,
    "maxY" : 1119,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 329,
        "y" : 1081
      },
      "to" : {
        "x" : 371,
        "y" : 1119
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 363,
        "y" : 1117
      },
      "b" : {
        "x" : 371,
        "y" : 1119
      },
      "c" : {
        "x" : 369,
        "y" : 1111
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 369,
        "y" : 1111
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 344,
        "y" : 1094
      },
      "b" : {
        "x" : 356,
        "y" : 1106
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 350,
        "y" : 1100
      }
    },
    "inputs" : [ {
      "id" : 130595
    } ],
    "outputs" : [ {
      "id" : 130603
    } ]
  } ],
  "shadows" : [ {
    "id" : 130626,
    "reactomeId" : 10729158,
    "displayName" : "TRIF (TICAM1)-mediated TLR4 signaling ",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1677,
      "y" : 1034
    },
    "minX" : 1589,
    "maxX" : 1766,
    "minY" : 901,
    "maxY" : 1167,
    "prop" : {
      "x" : 1589,
      "y" : 901,
      "width" : 177,
      "height" : 266
    },
    "points" : [ {
      "x" : 1589,
      "y" : 901
    }, {
      "x" : 1766,
      "y" : 901
    }, {
      "x" : 1766,
      "y" : 1167
    }, {
      "x" : 1589,
      "y" : 1167
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1787,
  "minY" : 0,
  "maxY" : 1237,
  "disease" : false
}