{ "dbId" : 10650554, "stableId" : "R-DRE-9648002", "displayName" : "RAS processing", "nodes" : [ { "id" : 8384, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 354, "y" : 664 }, "minX" : 328, "maxX" : 381, "minY" : 606, "maxY" : 679, "prop" : { "x" : 328, "y" : 649, "width" : 52, "height" : 30 }, "textPosition" : { "x" : 340, "y" : 653 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 375, "y" : 654 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 375, "y" : 654 } } }, "connectors" : [ { "edgeId" : 8381, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 354, "y" : 646 }, "to" : { "x" : 354, "y" : 606 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 350, "y" : 639 }, "b" : { "x" : 354, "y" : 646 }, "c" : { "x" : 358, "y" : 639 }, "type" : "ARROW", "centre" : { "x" : 358, "y" : 639 } } } ] }, { "id" : 8385, "reactomeId" : 10639774, "displayName" : "S-Farn-proRAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 488, "y" : 645 }, "minX" : 354, "maxX" : 534, "minY" : 606, "maxY" : 664, "prop" : { "x" : 443, "y" : 626, "width" : 91, "height" : 38 }, "textPosition" : { "x" : 462, "y" : 627 }, "connectors" : [ { "edgeId" : 8390, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8381, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 437, "y" : 631 }, "to" : { "x" : 354, "y" : 606 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 429, "y" : 633 }, "b" : { "x" : 437, "y" : 631 }, "c" : { "x" : 432, "y" : 625 }, "type" : "ARROW", "centre" : { "x" : 432, "y" : 625 } } } ] }, { "id" : 8386, "reactomeId" : 10604480, "displayName" : "FNTA:FNTB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 227, "y" : 552 }, "minX" : 186, "maxX" : 306, "minY" : 519, "maxY" : 605, "prop" : { "x" : 186, "y" : 537, "width" : 82, "height" : 30 }, "textPosition" : { "x" : 190, "y" : 546 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 268, "y" : 537 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 268, "y" : 537 } } }, "connectors" : [ { "edgeId" : 8388, "type" : "INPUT", "segments" : [ { "from" : { "x" : 225, "y" : 534 }, "to" : { "x" : 223, "y" : 519 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8381, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 250, "y" : 570 }, "to" : { "x" : 298, "y" : 599 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 302, "y" : 601 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 302, "y" : 601 } } } ] }, { "id" : 8387, "reactomeId" : 10639776, "displayName" : "FNTA:FNTB:FTase inhibitors", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 319, "y" : 489 }, "minX" : 258, "maxX" : 387, "minY" : 465, "maxY" : 598, "prop" : { "x" : 258, "y" : 471, "width" : 123, "height" : 37 }, "textPosition" : { "x" : 260, "y" : 473 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 381, "y" : 471 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 381, "y" : 471 } } }, "connectors" : [ { "edgeId" : 8388, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8381, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 317, "y" : 511 }, "to" : { "x" : 312, "y" : 598 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 308, "y" : 598 }, "b" : { "x" : 316, "y" : 598 }, "c" : { "x" : 312, "y" : 598 }, "type" : "STOP", "centre" : { "x" : 312, "y" : 598 } } } ] }, { "id" : 8389, "reactomeId" : 9653479, "displayName" : "FNTB inhibitors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 122, "y" : 499 }, "minX" : 60, "maxX" : 223, "minY" : 485, "maxY" : 519, "prop" : { "x" : 60, "y" : 485, "width" : 124, "height" : 28 }, "textPosition" : { "x" : 71, "y" : 488 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 8388, "type" : "INPUT", "segments" : [ { "from" : { "x" : 190, "y" : 511 }, "to" : { "x" : 223, "y" : 519 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8391, "reactomeId" : 10639739, "displayName" : "S-Farn-RAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 495, "y" : 548 }, "minX" : 449, "maxX" : 541, "minY" : 497, "maxY" : 561, "prop" : { "x" : 449, "y" : 535, "width" : 92, "height" : 26 }, "textPosition" : { "x" : 457, "y" : 537 }, "connectors" : [ { "edgeId" : 8390, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8393, "type" : "INPUT", "segments" : [ { "from" : { "x" : 494, "y" : 529 }, "to" : { "x" : 492, "y" : 497 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8392, "reactomeId" : 10639831, "displayName" : "rce1a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 656, "y" : 640 }, "minX" : 496, "maxX" : 721, "minY" : 587, "maxY" : 655, "prop" : { "x" : 616, "y" : 626, "width" : 81, "height" : 29 }, "textPosition" : { "x" : 634, "y" : 630 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 697, "y" : 626 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 697, "y" : 626 } } }, "connectors" : [ { "edgeId" : 8390, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 624, "y" : 623 }, "to" : { "x" : 554, "y" : 593 } }, { "from" : { "x" : 554, "y" : 593 }, "to" : { "x" : 504, "y" : 591 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 500, "y" : 591 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 500, "y" : 591 } } }, { "edgeId" : 8415, "type" : "INPUT", "segments" : [ { "from" : { "x" : 700, "y" : 643 }, "to" : { "x" : 721, "y" : 645 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8394, "reactomeId" : 71284, "displayName" : "AdoMet", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 432, "y" : 494 }, "minX" : 402, "maxX" : 492, "minY" : 478, "maxY" : 509, "prop" : { "x" : 402, "y" : 479, "width" : 61, "height" : 30 }, "textPosition" : { "x" : 405, "y" : 483 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 458, "y" : 484 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 458, "y" : 484 } } }, "connectors" : [ { "edgeId" : 8393, "type" : "INPUT", "segments" : [ { "from" : { "x" : 466, "y" : 495 }, "to" : { "x" : 492, "y" : 497 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8395, "reactomeId" : 71285, "displayName" : "AdoHcy", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 421, "y" : 422 }, "minX" : 391, "maxX" : 496, "minY" : 406, "maxY" : 450, "prop" : { "x" : 391, "y" : 407, "width" : 61, "height" : 30 }, "textPosition" : { "x" : 394, "y" : 411 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 447, "y" : 412 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 447, "y" : 412 } } }, "connectors" : [ { "edgeId" : 8393, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 455, "y" : 433 }, "to" : { "x" : 496, "y" : 450 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 463, "y" : 432 }, "b" : { "x" : 455, "y" : 433 }, "c" : { "x" : 460, "y" : 439 }, "type" : "ARROW", "centre" : { "x" : 460, "y" : 439 } } } ] }, { "id" : 8396, "reactomeId" : 10639749, "displayName" : "S-Farn-Me RAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 525, "y" : 402 }, "minX" : 475, "maxX" : 576, "minY" : 386, "maxY" : 450, "prop" : { "x" : 475, "y" : 386, "width" : 101, "height" : 32 }, "textPosition" : { "x" : 476, "y" : 391 }, "connectors" : [ { "edgeId" : 8393, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 515, "y" : 424 }, "to" : { "x" : 496, "y" : 450 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 514, "y" : 432 }, "b" : { "x" : 515, "y" : 424 }, "c" : { "x" : 508, "y" : 427 }, "type" : "ARROW", "centre" : { "x" : 508, "y" : 427 } } } ] }, { "id" : 8397, "reactomeId" : 10621733, "displayName" : "ICMT:Zn2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 823, "y" : 472 }, "minX" : 501, "maxX" : 866, "minY" : 455, "maxY" : 483, "prop" : { "x" : 786, "y" : 461, "width" : 74, "height" : 22 }, "textPosition" : { "x" : 801, "y" : 448 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 860, "y" : 461 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 860, "y" : 461 } } }, "connectors" : [ { "edgeId" : 8393, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 783, "y" : 472 }, "to" : { "x" : 509, "y" : 475 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 505, "y" : 475 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 505, "y" : 475 } } } ] }, { "id" : 8398, "reactomeId" : 10639751, "displayName" : "ICMT:Zn2+:Cysmethynil", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 840, "y" : 582 }, "minX" : 501, "maxX" : 895, "minY" : 474, "maxY" : 602, "prop" : { "x" : 791, "y" : 562, "width" : 98, "height" : 40 }, "textPosition" : { "x" : 799, "y" : 567 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 889, "y" : 562 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 889, "y" : 562 } } }, "connectors" : [ { "edgeId" : 8393, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 788, "y" : 566 }, "to" : { "x" : 502, "y" : 478 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 501, "y" : 482 }, "b" : { "x" : 503, "y" : 474 }, "c" : { "x" : 502, "y" : 478 }, "type" : "STOP", "centre" : { "x" : 502, "y" : 478 } } } ] }, { "id" : 8400, "reactomeId" : 10639787, "displayName" : "S-Farn-Me PalmS KRAS4A,HRAS, NRAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 616, "y" : 190 }, "minX" : 557, "maxX" : 676, "minY" : 161, "maxY" : 220, "prop" : { "x" : 557, "y" : 161, "width" : 119, "height" : 59 }, "textPosition" : { "x" : 558, "y" : 166 }, "connectors" : [ { "edgeId" : 8399, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8401, "reactomeId" : 10571353, "displayName" : "mature p21 RAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 584, "y" : 53 }, "minX" : 479, "maxX" : 639, "minY" : 23, "maxY" : 78, "prop" : { "x" : 530, "y" : 28, "width" : 109, "height" : 50 }, "textPosition" : { "x" : 530, "y" : 42 }, "connectors" : [ { "edgeId" : 8402, "type" : "INPUT", "segments" : [ { "from" : { "x" : 524, "y" : 37 }, "to" : { "x" : 479, "y" : 23 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8399, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8403, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 515, "y" : 105 }, "minX" : 479, "maxX" : 538, "minY" : 23, "maxY" : 120, "prop" : { "x" : 494, "y" : 90, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 498, "y" : 94 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 532, "y" : 95 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 532, "y" : 95 } } }, "connectors" : [ { "edgeId" : 8402, "type" : "INPUT", "segments" : [ { "from" : { "x" : 508, "y" : 87 }, "to" : { "x" : 479, "y" : 23 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 8404, "reactomeId" : 10639825, "displayName" : "S-Farn-Me KRAS4A, HRAS, NRAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 153, "y" : 39 }, "minX" : 89, "maxX" : 267, "minY" : 21, "maxY" : 57, "prop" : { "x" : 89, "y" : 21, "width" : 129, "height" : 36 }, "textPosition" : { "x" : 89, "y" : 21 }, "connectors" : [ { "edgeId" : 8402, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 224, "y" : 33 }, "to" : { "x" : 267, "y" : 30 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 231, "y" : 29 }, "b" : { "x" : 224, "y" : 33 }, "c" : { "x" : 231, "y" : 37 }, "type" : "ARROW", "centre" : { "x" : 231, "y" : 37 } } } ] }, { "id" : 8405, "reactomeId" : 8848337, "displayName" : "PALM(-)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 200, "y" : 106 }, "minX" : 169, "maxX" : 267, "minY" : 30, "maxY" : 121, "prop" : { "x" : 169, "y" : 91, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 173, "y" : 95 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 227, "y" : 96 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 227, "y" : 96 } } }, "connectors" : [ { "edgeId" : 8402, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 213, "y" : 88 }, "to" : { "x" : 267, "y" : 30 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 215, "y" : 80 }, "b" : { "x" : 213, "y" : 88 }, "c" : { "x" : 221, "y" : 86 }, "type" : "ARROW", "centre" : { "x" : 221, "y" : 86 } } } ] }, { "id" : 8406, "reactomeId" : 10639813, "displayName" : "LYPLA1 dimer, ABHD17A,B,C", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 422, "y" : 77 }, "minX" : 370, "maxX" : 471, "minY" : 34, "maxY" : 203, "prop" : { "x" : 374, "y" : 59, "width" : 97, "height" : 36 }, "textPosition" : { "x" : 374, "y" : 59 }, "connectors" : [ { "edgeId" : 8402, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 418, "y" : 53 }, "to" : { "x" : 415, "y" : 42 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 415, "y" : 38 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 415, "y" : 38 } } }, { "edgeId" : 8420, "type" : "INPUT", "segments" : [ { "from" : { "x" : 414, "y" : 101 }, "to" : { "x" : 370, "y" : 203 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8407, "reactomeId" : 10639815, "displayName" : "Palmostatin B:LYPLA1 dimer, ABHD17A,B,C", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 178, "y" : 179 }, "minX" : 130, "maxX" : 406, "minY" : 28, "maxY" : 204, "prop" : { "x" : 130, "y" : 154, "width" : 97, "height" : 50 }, "textPosition" : { "x" : 133, "y" : 141 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 227, "y" : 154 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 227, "y" : 154 } } }, "connectors" : [ { "edgeId" : 8402, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 216, "y" : 151 }, "to" : { "x" : 404, "y" : 31 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 402, "y" : 28 }, "b" : { "x" : 406, "y" : 34 }, "c" : { "x" : 404, "y" : 31 }, "type" : "STOP", "centre" : { "x" : 404, "y" : 31 } } }, { "edgeId" : 8420, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8409, "reactomeId" : 10639747, "displayName" : "kras", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 817, "y" : 413 }, "minX" : 771, "maxX" : 870, "minY" : 387, "maxY" : 433, "prop" : { "x" : 771, "y" : 393, "width" : 93, "height" : 40 }, "textPosition" : { "x" : 800, "y" : 402 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 864, "y" : 393 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 864, "y" : 393 } } }, "connectors" : [ { "edgeId" : 8408, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8410, "reactomeId" : 10571351, "displayName" : "kras", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1037, "y" : 43 }, "minX" : 976, "maxX" : 1105, "minY" : 21, "maxY" : 60, "prop" : { "x" : 976, "y" : 27, "width" : 123, "height" : 33 }, "textPosition" : { "x" : 1020, "y" : 33 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1099, "y" : 27 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1099, "y" : 27 } } }, "connectors" : [ { "edgeId" : 8408, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8412, "reactomeId" : 10571353, "displayName" : "mature p21 RAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 726, "y" : 52 }, "minX" : 674, "maxX" : 778, "minY" : 41, "maxY" : 87, "prop" : { "x" : 674, "y" : 41, "width" : 104, "height" : 22 }, "textPosition" : { "x" : 683, "y" : 35 }, "connectors" : [ { "edgeId" : 8411, "type" : "INPUT", "segments" : [ { "from" : { "x" : 740, "y" : 69 }, "to" : { "x" : 772, "y" : 87 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8413, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 718, "y" : 104 }, "minX" : 697, "maxX" : 772, "minY" : 87, "maxY" : 119, "prop" : { "x" : 697, "y" : 89, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 701, "y" : 93 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 734, "y" : 94 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 734, "y" : 94 } } }, "connectors" : [ { "edgeId" : 8411, "type" : "INPUT", "segments" : [ { "from" : { "x" : 742, "y" : 97 }, "to" : { "x" : 772, "y" : 87 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8414, "reactomeId" : 10572353, "displayName" : "p21 RAS:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 898, "y" : 72 }, "minX" : 852, "maxX" : 951, "minY" : 45, "maxY" : 93, "prop" : { "x" : 852, "y" : 51, "width" : 93, "height" : 42 }, "textPosition" : { "x" : 853, "y" : 72 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 945, "y" : 51 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 945, "y" : 51 } } }, "connectors" : [ { "edgeId" : 8411, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8416, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 654, "y" : 704 }, "minX" : 633, "maxX" : 721, "minY" : 645, "maxY" : 719, "prop" : { "x" : 633, "y" : 689, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 637, "y" : 693 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 671, "y" : 694 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 671, "y" : 694 } } }, "connectors" : [ { "edgeId" : 8415, "type" : "INPUT", "segments" : [ { "from" : { "x" : 671, "y" : 686 }, "to" : { "x" : 721, "y" : 645 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 8417, "reactomeId" : 10639886, "displayName" : "rce1a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 839, "y" : 633 }, "minX" : 763, "maxX" : 869, "minY" : 614, "maxY" : 646, "prop" : { "x" : 816, "y" : 620, "width" : 47, "height" : 26 }, "textPosition" : { "x" : 817, "y" : 622 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 863, "y" : 620 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 863, "y" : 620 } } }, "connectors" : [ { "edgeId" : 8415, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 813, "y" : 636 }, "to" : { "x" : 763, "y" : 645 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 807, "y" : 641 }, "b" : { "x" : 813, "y" : 636 }, "c" : { "x" : 805, "y" : 633 }, "type" : "ARROW", "centre" : { "x" : 805, "y" : 633 } } } ] }, { "id" : 8418, "reactomeId" : 10618157, "displayName" : "PolyUb", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 832, "y" : 714 }, "minX" : 763, "maxX" : 862, "minY" : 645, "maxY" : 726, "prop" : { "x" : 803, "y" : 703, "width" : 59, "height" : 23 }, "textPosition" : { "x" : 807, "y" : 704 }, "connectors" : [ { "edgeId" : 8415, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 820, "y" : 697 }, "to" : { "x" : 763, "y" : 645 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 812, "y" : 695 }, "b" : { "x" : 820, "y" : 697 }, "c" : { "x" : 818, "y" : 689 }, "type" : "ARROW", "centre" : { "x" : 818, "y" : 689 } } } ] }, { "id" : 8419, "reactomeId" : 10620252, "displayName" : "usp42", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 742, "y" : 713 }, "minX" : 706, "maxX" : 784, "minY" : 654, "maxY" : 727, "prop" : { "x" : 706, "y" : 700, "width" : 72, "height" : 27 }, "textPosition" : { "x" : 718, "y" : 703 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 778, "y" : 700 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 778, "y" : 700 } } }, "connectors" : [ { "edgeId" : 8415, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 742, "y" : 697 }, "to" : { "x" : 742, "y" : 662 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 742, "y" : 658 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 742, "y" : 658 } } } ] }, { "id" : 8421, "reactomeId" : 9647934, "displayName" : "Palmostatin B", "schemaClass" : "ChemicalDrug", "renderableClass" : "ChemicalDrug", "position" : { "x" : 404, "y" : 253 }, "minX" : 352, "maxX" : 457, "minY" : 203, "maxY" : 280, "prop" : { "x" : 352, "y" : 227, "width" : 105, "height" : 53 }, "textPosition" : { "x" : 357, "y" : 243 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 255, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 8420, "type" : "INPUT", "segments" : [ { "from" : { "x" : 385, "y" : 224 }, "to" : { "x" : 370, "y" : 203 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8423, "reactomeId" : 10639884, "displayName" : "phospho-kras", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1257, "y" : 46 }, "minX" : 1203, "maxX" : 1317, "minY" : 18, "maxY" : 69, "prop" : { "x" : 1203, "y" : 24, "width" : 108, "height" : 45 }, "textPosition" : { "x" : 1210, "y" : 36 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1311, "y" : 24 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1311, "y" : 24 } } }, "connectors" : [ { "edgeId" : 8422, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8424, "reactomeId" : 10639891, "displayName" : "phospho-kras", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1156, "y" : 235 }, "minX" : 1082, "maxX" : 1222, "minY" : 211, "maxY" : 280, "prop" : { "x" : 1096, "y" : 217, "width" : 120, "height" : 36 }, "textPosition" : { "x" : 1109, "y" : 224 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1216, "y" : 217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1216, "y" : 217 } } }, "connectors" : [ { "edgeId" : 8422, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8425, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1126, "y" : 256 }, "to" : { "x" : 1082, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8426, "reactomeId" : 10588423, "displayName" : "bcl2l1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1053, "y" : 248 }, "minX" : 1027, "maxX" : 1085, "minY" : 231, "maxY" : 280, "prop" : { "x" : 1027, "y" : 237, "width" : 52, "height" : 22 }, "textPosition" : { "x" : 1030, "y" : 237 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1079, "y" : 237 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1079, "y" : 237 } } }, "connectors" : [ { "edgeId" : 8425, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1062, "y" : 262 }, "to" : { "x" : 1082, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8427, "reactomeId" : 10639895, "displayName" : "p-S181-S-Farn-Me KRAS4B:BCL2L1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1060, "y" : 369 }, "minX" : 1007, "maxX" : 1119, "minY" : 338, "maxY" : 394, "prop" : { "x" : 1007, "y" : 344, "width" : 106, "height" : 50 }, "textPosition" : { "x" : 1010, "y" : 345 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1113, "y" : 344 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1113, "y" : 344 } } }, "connectors" : [ { "edgeId" : 8425, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8430, "reactomeId" : 10639749, "displayName" : "S-Farn-Me RAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 677, "y" : 395 }, "minX" : 615, "maxX" : 740, "minY" : 377, "maxY" : 413, "prop" : { "x" : 615, "y" : 377, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 628, "y" : 384 }, "connectors" : [ ] }, { "id" : 8445, "reactomeId" : 10650054, "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 903, "y" : 156 }, "minX" : 837, "maxX" : 969, "minY" : 124, "maxY" : 189, "prop" : { "x" : 837, "y" : 124, "width" : 132, "height" : 65 }, "textPosition" : { "x" : 844, "y" : 135 }, "connectors" : [ ] }, { "id" : 8382, "reactomeId" : 2530486, "displayName" : "FPP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 234, "y" : 652 }, "minX" : 208, "maxX" : 263, "minY" : 607, "maxY" : 665, "prop" : { "x" : 208, "y" : 639, "width" : 53, "height" : 26 }, "textPosition" : { "x" : 219, "y" : 641 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 256, "y" : 644 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 256, "y" : 644 } } }, "connectors" : [ { "edgeId" : 8381, "type" : "INPUT", "segments" : [ { "from" : { "x" : 242, "y" : 636 }, "to" : { "x" : 263, "y" : 607 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8383, "reactomeId" : 10639764, "displayName" : "pro-RAS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 185, "y" : 610 }, "minX" : 144, "maxX" : 263, "minY" : 599, "maxY" : 621, "prop" : { "x" : 144, "y" : 599, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 156, "y" : 599 }, "connectors" : [ { "edgeId" : 8381, "type" : "INPUT", "segments" : [ { "from" : { "x" : 232, "y" : 608 }, "to" : { "x" : 263, "y" : 607 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 8402, "reactomeId" : 10639828, "displayName" : "RAS proteins are depalmitoylated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 412, "y" : 26 }, "minX" : 267, "maxX" : 479, "minY" : 20, "maxY" : 32, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 479, "y" : 23 }, "to" : { "x" : 412, "y" : 26 } }, { "from" : { "x" : 412, "y" : 26 }, "to" : { "x" : 267, "y" : 30 } } ], "reactionShape" : { "a" : { "x" : 406, "y" : 20 }, "b" : { "x" : 418, "y" : 32 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 412, "y" : 26 } }, "inputs" : [ { "id" : 8403, "points" : [ { "x" : 508, "y" : 87 } ] }, { "id" : 8401, "points" : [ { "x" : 524, "y" : 37 } ] } ], "outputs" : [ { "id" : 8404, "points" : [ { "x" : 224, "y" : 33 } ] }, { "id" : 8405, "points" : [ { "x" : 213, "y" : 88 } ] } ], "catalysts" : [ { "id" : 8406, "points" : [ { "x" : 418, "y" : 53 } ] } ], "inhibitors" : [ { "id" : 8407, "points" : [ { "x" : 216, "y" : 151 } ] } ] }, { "id" : 8420, "reactomeId" : 10639817, "displayName" : "Palmostatin B binds RAS depalmitoylases", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 318, "y" : 190 }, "minX" : 230, "maxX" : 370, "minY" : 182, "maxY" : 203, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 370, "y" : 203 }, "to" : { "x" : 318, "y" : 190 } }, { "from" : { "x" : 318, "y" : 190 }, "to" : { "x" : 230, "y" : 182 } } ], "endShape" : { "a" : { "x" : 237, "y" : 179 }, "b" : { "x" : 230, "y" : 182 }, "c" : { "x" : 237, "y" : 187 }, "type" : "ARROW", "centre" : { "x" : 237, "y" : 187 } }, "reactionShape" : { "c" : { "x" : 318, "y" : 190 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 318, "y" : 190 } }, "inputs" : [ { "id" : 8406, "points" : [ { "x" : 414, "y" : 101 } ] }, { "id" : 8421, "points" : [ { "x" : 385, "y" : 224 } ] } ], "outputs" : [ { "id" : 8407 } ] }, { "id" : 8388, "reactomeId" : 10639791, "displayName" : "FNTB inhibitors bind FNTA:FNTB", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 230, "y" : 487 }, "minX" : 223, "maxX" : 255, "minY" : 481, "maxY" : 519, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 223, "y" : 519 }, "to" : { "x" : 230, "y" : 487 } }, { "from" : { "x" : 230, "y" : 487 }, "to" : { "x" : 255, "y" : 487 } } ], "endShape" : { "a" : { "x" : 248, "y" : 491 }, "b" : { "x" : 255, "y" : 487 }, "c" : { "x" : 248, "y" : 483 }, "type" : "ARROW", "centre" : { "x" : 248, "y" : 483 } }, "reactionShape" : { "c" : { "x" : 230, "y" : 487 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 230, "y" : 487 } }, "inputs" : [ { "id" : 8386, "points" : [ { "x" : 225, "y" : 534 } ] }, { "id" : 8389, "points" : [ { "x" : 190, "y" : 511 } ] } ], "outputs" : [ { "id" : 8387 } ] }, { "id" : 8422, "reactomeId" : 10639893, "displayName" : "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1235, "y" : 185 }, "minX" : 1184, "maxX" : 1256, "minY" : 72, "maxY" : 214, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1256, "y" : 72 }, "to" : { "x" : 1253, "y" : 169 } }, { "from" : { "x" : 1253, "y" : 169 }, "to" : { "x" : 1235, "y" : 185 } }, { "from" : { "x" : 1235, "y" : 185 }, "to" : { "x" : 1184, "y" : 214 } } ], "endShape" : { "a" : { "x" : 1188, "y" : 207 }, "b" : { "x" : 1184, "y" : 214 }, "c" : { "x" : 1192, "y" : 214 }, "type" : "ARROW", "centre" : { "x" : 1192, "y" : 214 } }, "reactionShape" : { "a" : { "x" : 1229, "y" : 179 }, "b" : { "x" : 1241, "y" : 191 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1235, "y" : 185 } }, "inputs" : [ { "id" : 8423 } ], "outputs" : [ { "id" : 8424 } ] }, { "id" : 8390, "reactomeId" : 10639834, "displayName" : "RCE1 cleaves S-Farn proRAS proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 488, "y" : 591 }, "minX" : 482, "maxX" : 494, "minY" : 567, "maxY" : 620, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 488, "y" : 620 }, "to" : { "x" : 488, "y" : 591 } }, { "from" : { "x" : 488, "y" : 591 }, "to" : { "x" : 492, "y" : 567 } } ], "endShape" : { "a" : { "x" : 495, "y" : 574 }, "b" : { "x" : 492, "y" : 567 }, "c" : { "x" : 487, "y" : 573 }, "type" : "ARROW", "centre" : { "x" : 487, "y" : 573 } }, "reactionShape" : { "a" : { "x" : 482, "y" : 585 }, "b" : { "x" : 494, "y" : 597 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 488, "y" : 591 } }, "inputs" : [ { "id" : 8385 } ], "outputs" : [ { "id" : 8391 } ], "catalysts" : [ { "id" : 8392, "points" : [ { "x" : 624, "y" : 623 }, { "x" : 554, "y" : 593 } ] } ] }, { "id" : 8408, "reactomeId" : 10639844, "displayName" : "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 970, "y" : 265 }, "minX" : 837, "maxX" : 1032, "minY" : 63, "maxY" : 390, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 837, "y" : 390 }, "to" : { "x" : 970, "y" : 265 } }, { "from" : { "x" : 970, "y" : 265 }, "to" : { "x" : 1032, "y" : 63 } } ], "endShape" : { "a" : { "x" : 1034, "y" : 71 }, "b" : { "x" : 1032, "y" : 63 }, "c" : { "x" : 1026, "y" : 68 }, "type" : "ARROW", "centre" : { "x" : 1026, "y" : 68 } }, "reactionShape" : { "a" : { "x" : 964, "y" : 259 }, "b" : { "x" : 976, "y" : 271 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 970, "y" : 265 } }, "inputs" : [ { "id" : 8409 } ], "outputs" : [ { "id" : 8410 } ] }, { "id" : 8393, "reactomeId" : 10639753, "displayName" : "ICMT methylates S-Farn RAS proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 493, "y" : 475 }, "minX" : 487, "maxX" : 499, "minY" : 450, "maxY" : 497, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 492, "y" : 497 }, "to" : { "x" : 493, "y" : 475 } }, { "from" : { "x" : 493, "y" : 475 }, "to" : { "x" : 496, "y" : 450 } } ], "reactionShape" : { "a" : { "x" : 487, "y" : 469 }, "b" : { "x" : 499, "y" : 481 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 493, "y" : 475 } }, "inputs" : [ { "id" : 8391, "points" : [ { "x" : 494, "y" : 529 } ] }, { "id" : 8394, "points" : [ { "x" : 466, "y" : 495 } ] } ], "outputs" : [ { "id" : 8395, "points" : [ { "x" : 455, "y" : 433 } ] }, { "id" : 8396, "points" : [ { "x" : 515, "y" : 424 } ] } ], "catalysts" : [ { "id" : 8397, "points" : [ { "x" : 783, "y" : 472 } ] } ], "inhibitors" : [ { "id" : 8398, "points" : [ { "x" : 788, "y" : 566 } ] } ] }, { "id" : 8425, "reactomeId" : 10639897, "displayName" : "pS181-S-Farn-Me KRAS4B binds BCL2L1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1058, "y" : 304 }, "minX" : 1052, "maxX" : 1082, "minY" : 280, "maxY" : 341, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1082, "y" : 280 }, "to" : { "x" : 1058, "y" : 304 } }, { "from" : { "x" : 1058, "y" : 304 }, "to" : { "x" : 1059, "y" : 341 } } ], "endShape" : { "a" : { "x" : 1055, "y" : 334 }, "b" : { "x" : 1059, "y" : 341 }, "c" : { "x" : 1063, "y" : 334 }, "type" : "ARROW", "centre" : { "x" : 1063, "y" : 334 } }, "reactionShape" : { "c" : { "x" : 1058, "y" : 304 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1058, "y" : 304 } }, "inputs" : [ { "id" : 8426, "points" : [ { "x" : 1062, "y" : 262 } ] }, { "id" : 8424, "points" : [ { "x" : 1126, "y" : 256 } ] } ], "outputs" : [ { "id" : 8427 } ] }, { "id" : 8411, "reactomeId" : 10639846, "displayName" : "mature p21 RAS binds GDP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 816, "y" : 84 }, "minX" : 772, "maxX" : 849, "minY" : 78, "maxY" : 90, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 772, "y" : 87 }, "to" : { "x" : 816, "y" : 84 } }, { "from" : { "x" : 816, "y" : 84 }, "to" : { "x" : 849, "y" : 78 } } ], "endShape" : { "a" : { "x" : 843, "y" : 83 }, "b" : { "x" : 849, "y" : 78 }, "c" : { "x" : 841, "y" : 75 }, "type" : "ARROW", "centre" : { "x" : 841, "y" : 75 } }, "reactionShape" : { "c" : { "x" : 816, "y" : 84 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 816, "y" : 84 } }, "inputs" : [ { "id" : 8412, "points" : [ { "x" : 740, "y" : 69 } ] }, { "id" : 8413, "points" : [ { "x" : 742, "y" : 97 } ] } ], "outputs" : [ { "id" : 8414 } ] }, { "id" : 8381, "reactomeId" : 10639778, "displayName" : "pro-RAS proteins are farnesylated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 312, "y" : 607 }, "minX" : 263, "maxX" : 354, "minY" : 601, "maxY" : 613, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 263, "y" : 607 }, "to" : { "x" : 312, "y" : 607 } }, { "from" : { "x" : 312, "y" : 607 }, "to" : { "x" : 354, "y" : 606 } } ], "reactionShape" : { "a" : { "x" : 306, "y" : 601 }, "b" : { "x" : 318, "y" : 613 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 312, "y" : 607 } }, "inputs" : [ { "id" : 8382, "points" : [ { "x" : 242, "y" : 636 } ] }, { "id" : 8383, "points" : [ { "x" : 232, "y" : 608 } ] } ], "outputs" : [ { "id" : 8384, "points" : [ { "x" : 354, "y" : 646 } ] }, { "id" : 8385, "points" : [ { "x" : 437, "y" : 631 } ] } ], "catalysts" : [ { "id" : 8386, "points" : [ { "x" : 250, "y" : 570 } ] } ], "inhibitors" : [ { "id" : 8387, "points" : [ { "x" : 317, "y" : 511 } ] } ] }, { "id" : 8415, "reactomeId" : 10639889, "displayName" : "USP17L2 deubiquitinates RCE1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 742, "y" : 646 }, "minX" : 721, "maxX" : 763, "minY" : 640, "maxY" : 652, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 721, "y" : 645 }, "to" : { "x" : 742, "y" : 646 } }, { "from" : { "x" : 742, "y" : 646 }, "to" : { "x" : 763, "y" : 645 } } ], "reactionShape" : { "a" : { "x" : 736, "y" : 640 }, "b" : { "x" : 748, "y" : 652 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 742, "y" : 646 } }, "inputs" : [ { "id" : 8416, "points" : [ { "x" : 671, "y" : 686 } ] }, { "id" : 8392, "points" : [ { "x" : 700, "y" : 643 } ] } ], "outputs" : [ { "id" : 8417, "points" : [ { "x" : 813, "y" : 636 } ] }, { "id" : 8418, "points" : [ { "x" : 820, "y" : 697 } ] } ], "catalysts" : [ { "id" : 8419, "points" : [ { "x" : 742, "y" : 697 } ] } ] }, { "id" : 8399, "reactomeId" : 10639789, "displayName" : "mature RAS proteins translocate to plasma membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 593, "y" : 115 }, "minX" : 587, "maxX" : 606, "minY" : 84, "maxY" : 155, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 606, "y" : 155 }, "to" : { "x" : 593, "y" : 115 } }, { "from" : { "x" : 593, "y" : 115 }, "to" : { "x" : 587, "y" : 84 } } ], "endShape" : { "a" : { "x" : 592, "y" : 90 }, "b" : { "x" : 587, "y" : 84 }, "c" : { "x" : 584, "y" : 92 }, "type" : "ARROW", "centre" : { "x" : 584, "y" : 92 } }, "reactionShape" : { "a" : { "x" : 587, "y" : 109 }, "b" : { "x" : 599, "y" : 121 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 593, "y" : 115 } }, "inputs" : [ { "id" : 8400 } ], "outputs" : [ { "id" : 8401 } ] } ], "compartments" : [ { "id" : 8433, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 745, "y" : 254 }, "minX" : 655, "maxX" : 836, "minY" : 180, "maxY" : 329, "prop" : { "x" : 655, "y" : 180, "width" : 181, "height" : 149 }, "textPosition" : { "x" : 726, "y" : 250 }, "insets" : { "x" : 665, "y" : 190, "width" : 161, "height" : 129 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 8400 ] }, { "id" : 8436, "reactomeId" : 17906, "displayName" : "mitochondrial outer membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1120, "y" : 314 }, "minX" : 1065, "maxX" : 1176, "minY" : 242, "maxY" : 386, "prop" : { "x" : 1065, "y" : 242, "width" : 111, "height" : 144 }, "textPosition" : { "x" : 1068, "y" : 271 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 8424, 8427, 8426 ] }, { "id" : 8428, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 724, "y" : 416 }, "minX" : 0, "maxX" : 1448, "minY" : 26, "maxY" : 806, "prop" : { "x" : 0, "y" : 26, "width" : 1448, "height" : 780 }, "textPosition" : { "x" : 260, "y" : 200 }, "insets" : { "x" : 10, "y" : 36, "width" : 1428, "height" : 760 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 8381, 8382, 8383, 8384, 8386, 8388, 8387, 8429, 8394, 8395, 8433, 8399, 8401, 8403, 8404, 8405, 8390, 8406, 8407, 8402, 8411, 8412, 8413, 8389, 8410, 8418, 8419, 8446, 8416, 8420, 8421, 8436, 8423, 8448, 8408, 8422, 8425, 8414, 8445, 8450 ] }, { "id" : 8429, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 664, "y" : 528 }, "minX" : 491, "maxX" : 837, "minY" : 401, "maxY" : 655, "prop" : { "x" : 491, "y" : 401, "width" : 346, "height" : 254 }, "textPosition" : { "x" : 631, "y" : 496 }, "insets" : { "x" : 501, "y" : 411, "width" : 326, "height" : 234 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 8385, 8392, 8391, 8393, 8396, 8397, 8430, 8409, 8447, 8398, 8415, 8417 ] } ], "notes" : [ ], "links" : [ { "id" : 8448, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 656, "y" : 52 }, "minX" : 645, "maxX" : 668, "minY" : 46, "maxY" : 58, "segments" : [ { "from" : { "x" : 668, "y" : 52 }, "to" : { "x" : 645, "y" : 52 } } ], "reactionShape" : { "a" : { "x" : 650, "y" : 46 }, "b" : { "x" : 662, "y" : 58 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 656, "y" : 52 } }, "inputs" : [ { "id" : 8412 } ], "outputs" : [ { "id" : 8401 } ] }, { "id" : 8449, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 886, "y" : 6 }, "minX" : 764, "maxX" : 973, "minY" : 0, "maxY" : 35, "segments" : [ { "from" : { "x" : 973, "y" : 27 }, "to" : { "x" : 886, "y" : 6 } }, { "from" : { "x" : 886, "y" : 6 }, "to" : { "x" : 764, "y" : 35 } } ], "reactionShape" : { "a" : { "x" : 880, "y" : 0 }, "b" : { "x" : 892, "y" : 12 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 886, "y" : 6 } }, "inputs" : [ { "id" : 8410 } ], "outputs" : [ { "id" : 8412 } ] }, { "id" : 8450, "renderableClass" : "Interaction", "position" : { "x" : 899, "y" : 108 }, "minX" : 893, "maxX" : 905, "minY" : 96, "maxY" : 121, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 898, "y" : 96 }, "to" : { "x" : 900, "y" : 121 } } ], "endShape" : { "a" : { "x" : 895, "y" : 114 }, "b" : { "x" : 900, "y" : 121 }, "c" : { "x" : 903, "y" : 114 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 903, "y" : 114 } }, "reactionShape" : { "a" : { "x" : 893, "y" : 102 }, "b" : { "x" : 905, "y" : 114 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 899, "y" : 108 } }, "inputs" : [ { "id" : 8414 } ], "outputs" : [ { "id" : 8445 } ] }, { "id" : 8446, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 595, "y" : 397 }, "minX" : 582, "maxX" : 609, "minY" : 391, "maxY" : 403, "segments" : [ { "from" : { "x" : 609, "y" : 396 }, "to" : { "x" : 582, "y" : 398 } } ], "reactionShape" : { "a" : { "x" : 589, "y" : 391 }, "b" : { "x" : 601, "y" : 403 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 595, "y" : 397 } }, "inputs" : [ { "id" : 8430 } ], "outputs" : [ { "id" : 8396 } ] }, { "id" : 8447, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 671, "y" : 448 }, "minX" : 575, "maxX" : 768, "minY" : 424, "maxY" : 454, "segments" : [ { "from" : { "x" : 768, "y" : 424 }, "to" : { "x" : 671, "y" : 448 } }, { "from" : { "x" : 671, "y" : 448 }, "to" : { "x" : 575, "y" : 424 } } ], "reactionShape" : { "a" : { "x" : 665, "y" : 442 }, "b" : { "x" : 677, "y" : 454 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 671, "y" : 448 } }, "inputs" : [ { "id" : 8409 } ], "outputs" : [ { "id" : 8396 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1448, "minY" : 0, "maxY" : 806, "disease" : false }