{
  "dbId" : 10650332,
  "stId" : "R-DRE-8878166",
  "speciesName" : "Danio rerio",
  "nodes" : [ {
    "dbId" : 113541,
    "stId" : "R-ALL-113541",
    "displayName" : "PPi [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 8807 ],
    "identifier" : "33019",
    "standardIdentifier" : "chebi:33019",
    "chebiIdentifier" : "chebi:33019",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10649188,
    "stId" : "R-DRE-5632684",
    "displayName" : "Hedgehog 'on' state",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 8832 ]
  }, {
    "dbId" : 10570983,
    "stId" : "R-DRE-170066",
    "displayName" : "phospho-p-T161-CDK1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7T3L7",
    "standardIdentifier" : "uniprot:Q7T3L7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10571085 ],
    "children" : [ ]
  }, {
    "dbId" : 10564904,
    "stId" : "R-DRE-113843",
    "displayName" : "CDK4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q08C29",
    "standardIdentifier" : "uniprot:Q08C29",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10634328 ],
    "children" : [ ]
  }, {
    "dbId" : 5618075,
    "stId" : "R-ALL-5618075",
    "displayName" : "androst-4-en-3,17-dione [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "16422",
    "standardIdentifier" : "chebi:16422",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5618091 ],
    "children" : [ ]
  }, {
    "dbId" : 10650352,
    "stId" : "R-DRE-8939902",
    "displayName" : "Regulation of RUNX2 expression and activity",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 8834 ]
  }, {
    "dbId" : 10636593,
    "stId" : "R-DRE-8985335",
    "displayName" : "RUNX2:SOX9 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8797 ],
    "parents" : [ ],
    "children" : [ 10632831, 10613911 ]
  }, {
    "dbId" : 10560754,
    "stId" : "R-DRE-113832",
    "displayName" : "ccnd1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q90459",
    "standardIdentifier" : "uniprot:Q90459",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ccnd1" ],
    "parents" : [ 10634328 ],
    "children" : [ ]
  }, {
    "dbId" : 5618113,
    "stId" : "R-ALL-5618113",
    "displayName" : "6-Dehydrotestosterone [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29117",
    "standardIdentifier" : "chebi:29117",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5618091 ],
    "children" : [ ]
  }, {
    "dbId" : 10632827,
    "stId" : "R-DRE-9007689",
    "displayName" : "RUNX2-P1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6U1J2",
    "standardIdentifier" : "uniprot:Q6U1J2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10632831 ],
    "children" : [ ]
  }, {
    "dbId" : 10648696,
    "stId" : "R-DRE-201451",
    "displayName" : "Signaling by BMP",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 8817 ]
  }, {
    "dbId" : 10632831,
    "stId" : "R-DRE-9007751",
    "displayName" : "RUNX2 [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "diagramIds" : [ 8789 ],
    "parents" : [ 10636593, 10633412, 10632851, 10632833 ],
    "children" : [ 10632827, 10632829 ]
  }, {
    "dbId" : 10637055,
    "stId" : "R-DRE-9008847",
    "displayName" : "phospho-p-S418-RUNX2-P2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6U1J2",
    "standardIdentifier" : "uniprot:Q6U1J2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10637057 ],
    "children" : [ ]
  }, {
    "dbId" : 10649596,
    "stId" : "R-DRE-1980143",
    "displayName" : "Signaling by NOTCH1",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 8837 ]
  }, {
    "dbId" : 10650300,
    "stId" : "R-DRE-8878171",
    "displayName" : "Transcriptional regulation by RUNX1",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 8823 ]
  }, {
    "dbId" : 10637052,
    "stId" : "R-DRE-9008852",
    "displayName" : "phospho-p-S432-RUNX2-P1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6U1J2",
    "standardIdentifier" : "uniprot:Q6U1J2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10637057 ],
    "children" : [ ]
  }, {
    "dbId" : 10632829,
    "stId" : "R-DRE-9007691",
    "displayName" : "RUNX2-P2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6U1J2",
    "standardIdentifier" : "uniprot:Q6U1J2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10632831 ],
    "children" : [ ]
  }, {
    "dbId" : 10633410,
    "stId" : "R-DRE-8938345",
    "displayName" : "RBM14 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 8793 ],
    "identifier" : "Q6P0G2",
    "standardIdentifier" : "uniprot:Q6P0G2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10633412 ],
    "children" : [ ]
  }, {
    "dbId" : 10637059,
    "stId" : "R-DRE-9008869",
    "displayName" : "p-S432-RUNX2:CBFB [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8806 ],
    "parents" : [ ],
    "children" : [ 10631446, 10637057 ]
  }, {
    "dbId" : 10632833,
    "stId" : "R-DRE-8877906",
    "displayName" : "RUNX2:AR:androgen [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8791 ],
    "parents" : [ ],
    "children" : [ 10632831, 10613339 ]
  }, {
    "dbId" : 10637057,
    "stId" : "R-DRE-9008850",
    "displayName" : "p-S432-RUNX2 [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "parents" : [ 10637059 ],
    "children" : [ 10637052, 10637055 ]
  }, {
    "dbId" : 10650054,
    "stId" : "R-DRE-5673001",
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 8847 ]
  }, {
    "dbId" : 10637063,
    "stId" : "R-DRE-2562518",
    "displayName" : "ppm1db [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 8808 ],
    "identifier" : "Q5U3H7",
    "standardIdentifier" : "uniprot:Q5U3H7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ppm1db" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10633412,
    "stId" : "R-DRE-8938353",
    "displayName" : "RUNX2:RBM14 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8794 ],
    "parents" : [ ],
    "children" : [ 10632831, 10633410 ]
  }, {
    "dbId" : 10579976,
    "stId" : "R-DRE-446174",
    "displayName" : "ar [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A4GT83",
    "standardIdentifier" : "uniprot:A4GT83",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ar" ],
    "parents" : [ 10613339 ],
    "children" : [ ]
  }, {
    "dbId" : 10571085,
    "stId" : "R-DRE-170160",
    "displayName" : "CCNB1:p-T161-CDK1 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8810 ],
    "parents" : [ ],
    "children" : [ 10570971, 10570983 ]
  }, {
    "dbId" : 29358,
    "stId" : "R-ALL-29358",
    "displayName" : "ATP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 8800 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113518,
    "stId" : "R-ALL-113518",
    "displayName" : "H2O [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 8805 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113582,
    "stId" : "R-ALL-113582",
    "displayName" : "ADP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 8801 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 5618084,
    "stId" : "R-ALL-5618084",
    "displayName" : "DHTEST [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "16330",
    "standardIdentifier" : "chebi:16330",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5618091 ],
    "children" : [ ]
  }, {
    "dbId" : 10632851,
    "stId" : "R-DRE-8865420",
    "displayName" : "RUNX2:CBFB [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8799 ],
    "parents" : [ ],
    "children" : [ 10632831, 10631446 ]
  }, {
    "dbId" : 10649936,
    "stId" : "R-DRE-5610787",
    "displayName" : "Hedgehog 'off' state",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 8838 ]
  }, {
    "dbId" : 10631446,
    "stId" : "R-DRE-8865293",
    "displayName" : "cbfb [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A0A140LGT1",
    "standardIdentifier" : "uniprot:A0A140LGT1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "cbfb" ],
    "parents" : [ 10637059, 10637019, 10632851 ],
    "children" : [ ]
  }, {
    "dbId" : 10637015,
    "stId" : "R-DRE-9008422",
    "displayName" : "phospho-p-S451-RUNX2-P2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6U1J2",
    "standardIdentifier" : "uniprot:Q6U1J2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10637017 ],
    "children" : [ ]
  }, {
    "dbId" : 10613911,
    "stId" : "R-DRE-3214954",
    "displayName" : "sox9a [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 8796 ],
    "identifier" : "Q9DFH2",
    "standardIdentifier" : "uniprot:Q9DFH2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "sox9a" ],
    "parents" : [ 10636593 ],
    "children" : [ ]
  }, {
    "dbId" : 10637012,
    "stId" : "R-DRE-9008409",
    "displayName" : "phospho-p-S465-RUNX2-P1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6U1J2",
    "standardIdentifier" : "uniprot:Q6U1J2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10637017 ],
    "children" : [ ]
  }, {
    "dbId" : 10637019,
    "stId" : "R-DRE-9008410",
    "displayName" : "p-S451-RUNX2:CBFB [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8802 ],
    "parents" : [ ],
    "children" : [ 10637017, 10631446 ]
  }, {
    "dbId" : 10613339,
    "stId" : "R-DRE-5618087",
    "displayName" : "AR:androgens [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8790 ],
    "parents" : [ 10632833 ],
    "children" : [ 5618091, 10579976 ]
  }, {
    "dbId" : 10570971,
    "stId" : "R-DRE-68901",
    "displayName" : "ccnb1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q9IB44",
    "standardIdentifier" : "uniprot:Q9IB44",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ccnb1" ],
    "parents" : [ 10571085 ],
    "children" : [ ]
  }, {
    "dbId" : 10634328,
    "stId" : "R-DRE-113844",
    "displayName" : "CDK4:CCND1 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 8803 ],
    "parents" : [ ],
    "children" : [ 10564904, 10560754 ]
  }, {
    "dbId" : 10637017,
    "stId" : "R-DRE-9008426",
    "displayName" : "p-S451-RUNX2 [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "parents" : [ 10637019 ],
    "children" : [ 10637012, 10637015 ]
  }, {
    "dbId" : 5618089,
    "stId" : "R-ALL-5618089",
    "displayName" : "TEST [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "17347",
    "standardIdentifier" : "chebi:17347",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5618091 ],
    "children" : [ ]
  }, {
    "dbId" : 5618091,
    "stId" : "R-ALL-5618091",
    "displayName" : "Androgen [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "parents" : [ 10613339 ],
    "children" : [ 5618075, 5618089, 5618113, 5618084 ]
  } ],
  "edges" : [ {
    "dbId" : 10636595,
    "stId" : "R-DRE-8985343",
    "displayName" : "RUNX2 binds SOX9",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10632831, 10613911 ],
    "outputs" : [ 10636593 ],
    "efs" : [ ],
    "diagramIds" : [ 8795 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10632835,
    "stId" : "R-DRE-8877902",
    "displayName" : "Activated AR binds RUNX2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10632831, 10613339 ],
    "outputs" : [ 10632833 ],
    "efs" : [ ],
    "diagramIds" : [ 8788 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10633414,
    "stId" : "R-DRE-8938356",
    "displayName" : "RMB14 binds RUNX2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10632831, 10633410 ],
    "outputs" : [ 10633412 ],
    "efs" : [ ],
    "diagramIds" : [ 8792 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10637066,
    "stId" : "R-DRE-9008822",
    "displayName" : "PPM1D dephosphorylates RUNX2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113518, 10637059 ],
    "outputs" : [ 113541, 10632851 ],
    "catalysts" : [ 10637063 ],
    "efs" : [ ],
    "diagramIds" : [ 8804 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10637096,
    "stId" : "R-DRE-9009282",
    "displayName" : "CDK1 phosphorylates RUNX2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29358, 10632851 ],
    "outputs" : [ 113582, 10637019 ],
    "catalysts" : [ 10571085 ],
    "efs" : [ ],
    "diagramIds" : [ 8809 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10637022,
    "stId" : "R-DRE-9008412",
    "displayName" : "CDK4 phosphorylates RUNX2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29358, 10632851 ],
    "outputs" : [ 113582, 10637019 ],
    "catalysts" : [ 10634328 ],
    "efs" : [ ],
    "diagramIds" : [ 8798 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10650330,
    "stId" : "R-DRE-8941326",
    "displayName" : "RUNX2 regulates bone development",
    "events" : [ 10633414, 10632835 ]
  }, {
    "dbId" : 10650328,
    "stId" : "R-DRE-8940973",
    "displayName" : "RUNX2 regulates osteoblast differentiation",
    "events" : [ 10632835 ]
  } ]
}