{
  "dbId" : 10649886,
  "stableId" : "R-DRE-5250924",
  "displayName" : "B-WICH complex positively regulates rRNA expression",
  "nodes" : [ {
    "id" : 100963,
    "reactomeId" : 113560,
    "displayName" : "Ac-CoA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 269,
      "y" : 443
    },
    "minX" : 242,
    "maxX" : 352,
    "minY" : 427,
    "maxY" : 471,
    "prop" : {
      "x" : 242,
      "y" : 428,
      "width" : 55,
      "height" : 30
    },
    "textPosition" : {
      "x" : 244,
      "y" : 432
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 292,
          "y" : 433
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 292,
          "y" : 433
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100962,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 300,
          "y" : 452
        },
        "to" : {
          "x" : 352,
          "y" : 471
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 320,
            "y" : 455
          },
          "b" : {
            "x" : 332,
            "y" : 467
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 326,
            "y" : 461
          }
        }
      }
    } ]
  }, {
    "id" : 100965,
    "reactomeId" : 10611184,
    "displayName" : "Nucleosome (H3K9ac)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 622,
      "y" : 503
    },
    "minX" : 496,
    "maxX" : 715,
    "minY" : 471,
    "maxY" : 515,
    "prop" : {
      "x" : 536,
      "y" : 491,
      "width" : 173,
      "height" : 24
    },
    "textPosition" : {
      "x" : 549,
      "y" : 494
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 709,
          "y" : 491
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 709,
          "y" : 491
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100962,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 574,
          "y" : 488
        },
        "to" : {
          "x" : 496,
          "y" : 471
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 566,
          "y" : 490
        },
        "b" : {
          "x" : 574,
          "y" : 488
        },
        "c" : {
          "x" : 568,
          "y" : 483
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 568,
          "y" : 483
        }
      }
    } ]
  }, {
    "id" : 100964,
    "reactomeId" : 10563357,
    "displayName" : "Nucleosome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 266,
      "y" : 495
    },
    "minX" : 221,
    "maxX" : 352,
    "minY" : 471,
    "maxY" : 508,
    "prop" : {
      "x" : 221,
      "y" : 483,
      "width" : 91,
      "height" : 25
    },
    "textPosition" : {
      "x" : 224,
      "y" : 487
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 312,
          "y" : 483
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 312,
          "y" : 483
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100962,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 310,
          "y" : 480
        },
        "to" : {
          "x" : 352,
          "y" : 471
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100967,
    "reactomeId" : 10611188,
    "displayName" : "B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 423,
      "y" : 394
    },
    "minX" : 275,
    "maxX" : 577,
    "minY" : 375,
    "maxY" : 463,
    "prop" : {
      "x" : 275,
      "y" : 381,
      "width" : 296,
      "height" : 27
    },
    "textPosition" : {
      "x" : 285,
      "y" : 387
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 571,
          "y" : 381
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 571,
          "y" : 381
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100962,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 422,
          "y" : 411
        },
        "to" : {
          "x" : 422,
          "y" : 455
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 422,
          "y" : 459
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 422,
          "y" : 459
        }
      }
    } ]
  }, {
    "id" : 100966,
    "reactomeId" : 2485002,
    "displayName" : "CoA-SH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 587,
      "y" : 444
    },
    "minX" : 496,
    "maxX" : 617,
    "minY" : 428,
    "maxY" : 471,
    "prop" : {
      "x" : 559,
      "y" : 429,
      "width" : 57,
      "height" : 30
    },
    "textPosition" : {
      "x" : 561,
      "y" : 433
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 611,
          "y" : 434
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 611,
          "y" : 434
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100962,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 556,
          "y" : 452
        },
        "to" : {
          "x" : 496,
          "y" : 471
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 520,
            "y" : 455
          },
          "b" : {
            "x" : 532,
            "y" : 467
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 526,
            "y" : 461
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 551,
          "y" : 458
        },
        "b" : {
          "x" : 556,
          "y" : 452
        },
        "c" : {
          "x" : 548,
          "y" : 450
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 548,
          "y" : 450
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 100962,
    "reactomeId" : 10611191,
    "displayName" : "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 422,
      "y" : 471
    },
    "minX" : 352,
    "maxX" : 496,
    "minY" : 465,
    "maxY" : 477,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 352,
        "y" : 471
      },
      "to" : {
        "x" : 422,
        "y" : 471
      }
    }, {
      "from" : {
        "x" : 422,
        "y" : 471
      },
      "to" : {
        "x" : 496,
        "y" : 471
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 416,
        "y" : 465
      },
      "b" : {
        "x" : 428,
        "y" : 477
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 422,
        "y" : 471
      }
    },
    "inputs" : [ {
      "id" : 100963,
      "points" : [ {
        "x" : 300,
        "y" : 452
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 100964,
      "points" : [ {
        "x" : 310,
        "y" : 480
      } ]
    } ],
    "outputs" : [ {
      "id" : 100965,
      "points" : [ {
        "x" : 574,
        "y" : 488
      } ]
    }, {
      "id" : 100966,
      "points" : [ {
        "x" : 556,
        "y" : 452
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 100967,
      "points" : [ {
        "x" : 422,
        "y" : 411
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 100968,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 371,
      "y" : 276
    },
    "minX" : 0,
    "maxX" : 743,
    "minY" : 0,
    "maxY" : 552,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 743,
      "height" : 552
    },
    "textPosition" : {
      "x" : 24,
      "y" : 507
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 723,
      "height" : 532
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 100967, 100962, 100963, 100964, 100965, 100966 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 743,
  "minY" : 0,
  "maxY" : 552,
  "disease" : false
}