{
  "dbId" : 10649856,
  "stableId" : "R-DRE-4615885",
  "displayName" : "SUMOylation of DNA replication proteins",
  "nodes" : [ {
    "id" : 26049,
    "reactomeId" : 10609420,
    "displayName" : "top1a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 87,
      "y" : 664
    },
    "minX" : 57,
    "maxX" : 152,
    "minY" : 646,
    "maxY" : 691,
    "prop" : {
      "x" : 57,
      "y" : 652,
      "width" : 60,
      "height" : 24
    },
    "textPosition" : {
      "x" : 64,
      "y" : 653
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 117,
          "y" : 652
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 117,
          "y" : 652
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26048,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 115,
          "y" : 679
        },
        "to" : {
          "x" : 152,
          "y" : 691
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26050,
    "reactomeId" : 10605072,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 237,
      "y" : 665
    },
    "minX" : 152,
    "maxX" : 317,
    "minY" : 647,
    "maxY" : 713,
    "prop" : {
      "x" : 163,
      "y" : 653,
      "width" : 148,
      "height" : 24
    },
    "textPosition" : {
      "x" : 177,
      "y" : 656
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 311,
          "y" : 653
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 311,
          "y" : 653
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26048,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 197,
          "y" : 680
        },
        "to" : {
          "x" : 152,
          "y" : 691
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 26048,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 216,
          "y" : 680
        },
        "to" : {
          "x" : 166,
          "y" : 707
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 163,
          "y" : 709
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 163,
          "y" : 709
        }
      }
    } ]
  }, {
    "id" : 26051,
    "reactomeId" : 10609423,
    "displayName" : "top1a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 94,
      "y" : 769
    },
    "minX" : 43,
    "maxX" : 153,
    "minY" : 737,
    "maxY" : 790,
    "prop" : {
      "x" : 43,
      "y" : 749,
      "width" : 102,
      "height" : 41
    },
    "textPosition" : {
      "x" : 71,
      "y" : 759
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 145,
          "y" : 749
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 145,
          "y" : 749
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26048,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 131,
          "y" : 746
        },
        "to" : {
          "x" : 153,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 136,
          "y" : 740
        },
        "b" : {
          "x" : 131,
          "y" : 746
        },
        "c" : {
          "x" : 139,
          "y" : 747
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 139,
          "y" : 747
        }
      }
    } ]
  }, {
    "id" : 26052,
    "reactomeId" : 10605064,
    "displayName" : "ube2ia",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 229,
      "y" : 771
    },
    "minX" : 153,
    "maxX" : 271,
    "minY" : 737,
    "maxY" : 784,
    "prop" : {
      "x" : 194,
      "y" : 759,
      "width" : 71,
      "height" : 25
    },
    "textPosition" : {
      "x" : 204,
      "y" : 761
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 265,
          "y" : 759
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 265,
          "y" : 759
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26048,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 201,
          "y" : 756
        },
        "to" : {
          "x" : 153,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 193,
          "y" : 757
        },
        "b" : {
          "x" : 201,
          "y" : 756
        },
        "c" : {
          "x" : 196,
          "y" : 750
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 196,
          "y" : 750
        }
      }
    } ]
  }, {
    "id" : 26054,
    "reactomeId" : 10609397,
    "displayName" : "top2a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 556,
      "y" : 586
    },
    "minX" : 476,
    "maxX" : 618,
    "minY" : 568,
    "maxY" : 669,
    "prop" : {
      "x" : 520,
      "y" : 574,
      "width" : 72,
      "height" : 25
    },
    "textPosition" : {
      "x" : 533,
      "y" : 576
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 592,
          "y" : 574
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 592,
          "y" : 574
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26053,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 565,
          "y" : 602
        },
        "to" : {
          "x" : 618,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 26058,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 543,
          "y" : 602
        },
        "to" : {
          "x" : 476,
          "y" : 668
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26055,
    "reactomeId" : 10605072,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 667,
      "y" : 614
    },
    "minX" : 600,
    "maxX" : 740,
    "minY" : 593,
    "maxY" : 693,
    "prop" : {
      "x" : 600,
      "y" : 599,
      "width" : 134,
      "height" : 30
    },
    "textPosition" : {
      "x" : 607,
      "y" : 608
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 734,
          "y" : 599
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 734,
          "y" : 599
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26053,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 653,
          "y" : 632
        },
        "to" : {
          "x" : 618,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 26053,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 658,
          "y" : 632
        },
        "to" : {
          "x" : 625,
          "y" : 685
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 623,
          "y" : 689
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 623,
          "y" : 689
        }
      }
    } ]
  }, {
    "id" : 26056,
    "reactomeId" : 10609400,
    "displayName" : "top2a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 687,
      "y" : 802
    },
    "minX" : 638,
    "maxX" : 741,
    "minY" : 737,
    "maxY" : 828,
    "prop" : {
      "x" : 639,
      "y" : 776,
      "width" : 96,
      "height" : 52
    },
    "textPosition" : {
      "x" : 664,
      "y" : 791
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 735,
          "y" : 776
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 735,
          "y" : 776
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26053,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 667,
          "y" : 773
        },
        "to" : {
          "x" : 638,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 660,
          "y" : 770
        },
        "b" : {
          "x" : 667,
          "y" : 773
        },
        "c" : {
          "x" : 666,
          "y" : 765
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 666,
          "y" : 765
        }
      }
    } ]
  }, {
    "id" : 26057,
    "reactomeId" : 10605064,
    "displayName" : "ube2ia",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 568,
      "y" : 791
    },
    "minX" : 503,
    "maxX" : 638,
    "minY" : 731,
    "maxY" : 804,
    "prop" : {
      "x" : 533,
      "y" : 779,
      "width" : 71,
      "height" : 25
    },
    "textPosition" : {
      "x" : 543,
      "y" : 781
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 604,
          "y" : 779
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 604,
          "y" : 779
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26053,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 584,
          "y" : 776
        },
        "to" : {
          "x" : 638,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 587,
          "y" : 769
        },
        "b" : {
          "x" : 584,
          "y" : 776
        },
        "c" : {
          "x" : 592,
          "y" : 775
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 592,
          "y" : 775
        }
      }
    }, {
      "edgeId" : 26058,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 554,
          "y" : 776
        },
        "to" : {
          "x" : 503,
          "y" : 731
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 522,
            "y" : 747
          },
          "b" : {
            "x" : 534,
            "y" : 759
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 528,
            "y" : 753
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 546,
          "y" : 774
        },
        "b" : {
          "x" : 554,
          "y" : 776
        },
        "c" : {
          "x" : 551,
          "y" : 768
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 551,
          "y" : 768
        }
      }
    } ]
  }, {
    "id" : 26059,
    "reactomeId" : 10605168,
    "displayName" : "UBE2I:SUMO2,UBE2I:SUMO3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 422,
      "y" : 607
    },
    "minX" : 366,
    "maxX" : 478,
    "minY" : 587,
    "maxY" : 668,
    "prop" : {
      "x" : 366,
      "y" : 587,
      "width" : 112,
      "height" : 41
    },
    "textPosition" : {
      "x" : 374,
      "y" : 590
    },
    "connectors" : [ {
      "edgeId" : 26058,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 440,
          "y" : 634
        },
        "to" : {
          "x" : 476,
          "y" : 668
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 452,
            "y" : 645
          },
          "b" : {
            "x" : 464,
            "y" : 657
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 458,
            "y" : 651
          }
        }
      }
    } ]
  }, {
    "id" : 26060,
    "reactomeId" : 10609414,
    "displayName" : "top2a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 461,
      "y" : 793
    },
    "minX" : 397,
    "maxX" : 532,
    "minY" : 731,
    "maxY" : 810,
    "prop" : {
      "x" : 397,
      "y" : 777,
      "width" : 129,
      "height" : 33
    },
    "textPosition" : {
      "x" : 439,
      "y" : 783
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 526,
          "y" : 777
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 526,
          "y" : 777
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26058,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 472,
          "y" : 774
        },
        "to" : {
          "x" : 503,
          "y" : 731
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 473,
          "y" : 766
        },
        "b" : {
          "x" : 472,
          "y" : 774
        },
        "c" : {
          "x" : 479,
          "y" : 771
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 479,
          "y" : 771
        }
      }
    } ]
  }, {
    "id" : 26061,
    "reactomeId" : 10561025,
    "displayName" : "PIAS4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 437,
      "y" : 700
    },
    "minX" : 407,
    "maxX" : 495,
    "minY" : 682,
    "maxY" : 713,
    "prop" : {
      "x" : 407,
      "y" : 688,
      "width" : 60,
      "height" : 25
    },
    "textPosition" : {
      "x" : 415,
      "y" : 690
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 467,
          "y" : 688
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 467,
          "y" : 688
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26058,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 470,
          "y" : 700
        },
        "to" : {
          "x" : 487,
          "y" : 701
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 491,
          "y" : 701
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 491,
          "y" : 701
        }
      }
    } ]
  }, {
    "id" : 26063,
    "reactomeId" : 10609406,
    "displayName" : "top2b",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 98,
      "y" : 465
    },
    "minX" : 66,
    "maxX" : 166,
    "minY" : 446,
    "maxY" : 492,
    "prop" : {
      "x" : 66,
      "y" : 452,
      "width" : 64,
      "height" : 26
    },
    "textPosition" : {
      "x" : 75,
      "y" : 454
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 130,
          "y" : 452
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 130,
          "y" : 452
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26062,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 133,
          "y" : 477
        },
        "to" : {
          "x" : 166,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26064,
    "reactomeId" : 10605072,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 243,
      "y" : 465
    },
    "minX" : 166,
    "maxX" : 321,
    "minY" : 447,
    "maxY" : 508,
    "prop" : {
      "x" : 171,
      "y" : 453,
      "width" : 144,
      "height" : 24
    },
    "textPosition" : {
      "x" : 183,
      "y" : 456
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 315,
          "y" : 453
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 315,
          "y" : 453
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26062,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 208,
          "y" : 480
        },
        "to" : {
          "x" : 166,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 26062,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 222,
          "y" : 480
        },
        "to" : {
          "x" : 180,
          "y" : 502
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 177,
          "y" : 504
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 177,
          "y" : 504
        }
      }
    } ]
  }, {
    "id" : 26065,
    "reactomeId" : 10609409,
    "displayName" : "top2b",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 79,
      "y" : 554
    },
    "minX" : 31,
    "maxX" : 167,
    "minY" : 526,
    "maxY" : 577,
    "prop" : {
      "x" : 31,
      "y" : 532,
      "width" : 96,
      "height" : 45
    },
    "textPosition" : {
      "x" : 56,
      "y" : 544
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 127,
          "y" : 532
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 127,
          "y" : 532
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26062,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 130,
          "y" : 542
        },
        "to" : {
          "x" : 167,
          "y" : 533
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 136,
          "y" : 536
        },
        "b" : {
          "x" : 130,
          "y" : 542
        },
        "c" : {
          "x" : 138,
          "y" : 544
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 138,
          "y" : 544
        }
      }
    } ]
  }, {
    "id" : 26066,
    "reactomeId" : 10605064,
    "displayName" : "ube2ia",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 250,
      "y" : 548
    },
    "minX" : 167,
    "maxX" : 289,
    "minY" : 529,
    "maxY" : 562,
    "prop" : {
      "x" : 218,
      "y" : 535,
      "width" : 65,
      "height" : 27
    },
    "textPosition" : {
      "x" : 225,
      "y" : 538
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 283,
          "y" : 535
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 283,
          "y" : 535
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26062,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 215,
          "y" : 542
        },
        "to" : {
          "x" : 167,
          "y" : 533
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 207,
          "y" : 545
        },
        "b" : {
          "x" : 215,
          "y" : 542
        },
        "c" : {
          "x" : 209,
          "y" : 537
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 209,
          "y" : 537
        }
      }
    } ]
  }, {
    "id" : 26044,
    "reactomeId" : 10560591,
    "displayName" : "pcna",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 85,
      "y" : 230
    },
    "minX" : 52,
    "maxX" : 152,
    "minY" : 212,
    "maxY" : 267,
    "prop" : {
      "x" : 52,
      "y" : 218,
      "width" : 66,
      "height" : 25
    },
    "textPosition" : {
      "x" : 65,
      "y" : 220
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 118,
          "y" : 218
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 118,
          "y" : 218
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26043,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 107,
          "y" : 246
        },
        "to" : {
          "x" : 152,
          "y" : 267
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26045,
    "reactomeId" : 10605072,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 235,
      "y" : 236
    },
    "minX" : 152,
    "maxX" : 315,
    "minY" : 218,
    "maxY" : 288,
    "prop" : {
      "x" : 161,
      "y" : 224,
      "width" : 148,
      "height" : 24
    },
    "textPosition" : {
      "x" : 175,
      "y" : 227
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 309,
          "y" : 224
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 309,
          "y" : 224
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26043,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 202,
          "y" : 251
        },
        "to" : {
          "x" : 152,
          "y" : 267
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 171,
            "y" : 253
          },
          "b" : {
            "x" : 183,
            "y" : 265
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 177,
            "y" : 259
          }
        }
      }
    }, {
      "edgeId" : 26043,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 216,
          "y" : 251
        },
        "to" : {
          "x" : 166,
          "y" : 282
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 162,
          "y" : 284
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 162,
          "y" : 284
        }
      }
    } ]
  }, {
    "id" : 26046,
    "reactomeId" : 10605064,
    "displayName" : "ube2ia",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 247,
      "y" : 344
    },
    "minX" : 152,
    "maxX" : 289,
    "minY" : 310,
    "maxY" : 357,
    "prop" : {
      "x" : 212,
      "y" : 332,
      "width" : 71,
      "height" : 25
    },
    "textPosition" : {
      "x" : 222,
      "y" : 334
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 283,
          "y" : 332
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 283,
          "y" : 332
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26043,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 212,
          "y" : 329
        },
        "to" : {
          "x" : 152,
          "y" : 310
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 176,
            "y" : 313
          },
          "b" : {
            "x" : 188,
            "y" : 325
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 182,
            "y" : 319
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 204,
          "y" : 331
        },
        "b" : {
          "x" : 212,
          "y" : 329
        },
        "c" : {
          "x" : 207,
          "y" : 323
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 207,
          "y" : 323
        }
      }
    } ]
  }, {
    "id" : 26047,
    "reactomeId" : 10609260,
    "displayName" : "pcna",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 94,
      "y" : 353
    },
    "minX" : 28,
    "maxX" : 167,
    "minY" : 310,
    "maxY" : 376,
    "prop" : {
      "x" : 28,
      "y" : 331,
      "width" : 133,
      "height" : 45
    },
    "textPosition" : {
      "x" : 75,
      "y" : 343
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 161,
          "y" : 331
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 161,
          "y" : 331
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26043,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 124,
          "y" : 328
        },
        "to" : {
          "x" : 152,
          "y" : 310
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 128,
          "y" : 321
        },
        "b" : {
          "x" : 124,
          "y" : 328
        },
        "c" : {
          "x" : 132,
          "y" : 328
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 132,
          "y" : 328
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 26048,
    "reactomeId" : 10609425,
    "displayName" : "SUMOylation of TOP1 with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 152,
      "y" : 715
    },
    "minX" : 146,
    "maxX" : 158,
    "minY" : 691,
    "maxY" : 737,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 152,
        "y" : 691
      },
      "to" : {
        "x" : 152,
        "y" : 715
      }
    }, {
      "from" : {
        "x" : 152,
        "y" : 715
      },
      "to" : {
        "x" : 153,
        "y" : 737
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 146,
        "y" : 709
      },
      "b" : {
        "x" : 158,
        "y" : 721
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 152,
        "y" : 715
      }
    },
    "inputs" : [ {
      "id" : 26049,
      "points" : [ {
        "x" : 115,
        "y" : 679
      } ]
    }, {
      "id" : 26050,
      "points" : [ {
        "x" : 197,
        "y" : 680
      } ]
    } ],
    "outputs" : [ {
      "id" : 26051,
      "points" : [ {
        "x" : 131,
        "y" : 746
      } ]
    }, {
      "id" : 26052,
      "points" : [ {
        "x" : 201,
        "y" : 756
      } ]
    } ],
    "catalysts" : [ {
      "id" : 26050,
      "points" : [ {
        "x" : 216,
        "y" : 680
      } ]
    } ]
  }, {
    "id" : 26053,
    "reactomeId" : 10609402,
    "displayName" : "SUMOylation of TOP2A with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 617,
      "y" : 699
    },
    "minX" : 611,
    "maxX" : 638,
    "minY" : 669,
    "maxY" : 737,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 618,
        "y" : 669
      },
      "to" : {
        "x" : 617,
        "y" : 699
      }
    }, {
      "from" : {
        "x" : 617,
        "y" : 699
      },
      "to" : {
        "x" : 638,
        "y" : 737
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 611,
        "y" : 693
      },
      "b" : {
        "x" : 623,
        "y" : 705
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 617,
        "y" : 699
      }
    },
    "inputs" : [ {
      "id" : 26054,
      "points" : [ {
        "x" : 565,
        "y" : 602
      } ]
    }, {
      "id" : 26055,
      "points" : [ {
        "x" : 653,
        "y" : 632
      } ]
    } ],
    "outputs" : [ {
      "id" : 26056,
      "points" : [ {
        "x" : 667,
        "y" : 773
      } ]
    }, {
      "id" : 26057,
      "points" : [ {
        "x" : 584,
        "y" : 776
      } ]
    } ],
    "catalysts" : [ {
      "id" : 26055,
      "points" : [ {
        "x" : 658,
        "y" : 632
      } ]
    } ]
  }, {
    "id" : 26058,
    "reactomeId" : 10609416,
    "displayName" : "PIAS4 SUMOylates TOP2A with SUMO2,3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 503,
      "y" : 702
    },
    "minX" : 476,
    "maxX" : 509,
    "minY" : 668,
    "maxY" : 731,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 476,
        "y" : 668
      },
      "to" : {
        "x" : 503,
        "y" : 702
      }
    }, {
      "from" : {
        "x" : 503,
        "y" : 702
      },
      "to" : {
        "x" : 503,
        "y" : 731
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 497,
        "y" : 696
      },
      "b" : {
        "x" : 509,
        "y" : 708
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 503,
        "y" : 702
      }
    },
    "inputs" : [ {
      "id" : 26054,
      "points" : [ {
        "x" : 543,
        "y" : 602
      } ]
    }, {
      "id" : 26059,
      "points" : [ {
        "x" : 440,
        "y" : 634
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 26060,
      "points" : [ {
        "x" : 472,
        "y" : 774
      } ]
    }, {
      "id" : 26057,
      "points" : [ {
        "x" : 554,
        "y" : 776
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 26061,
      "points" : [ {
        "x" : 470,
        "y" : 700
      } ]
    } ]
  }, {
    "id" : 26043,
    "reactomeId" : 10609262,
    "displayName" : "SUMOylation of PCNA with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 152,
      "y" : 290
    },
    "minX" : 146,
    "maxX" : 158,
    "minY" : 267,
    "maxY" : 310,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 152,
        "y" : 267
      },
      "to" : {
        "x" : 152,
        "y" : 290
      }
    }, {
      "from" : {
        "x" : 152,
        "y" : 290
      },
      "to" : {
        "x" : 152,
        "y" : 310
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 146,
        "y" : 284
      },
      "b" : {
        "x" : 158,
        "y" : 296
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 152,
        "y" : 290
      }
    },
    "inputs" : [ {
      "id" : 26044,
      "points" : [ {
        "x" : 107,
        "y" : 246
      } ]
    }, {
      "id" : 26045,
      "points" : [ {
        "x" : 202,
        "y" : 251
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 26046,
      "points" : [ {
        "x" : 212,
        "y" : 329
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 26047,
      "points" : [ {
        "x" : 124,
        "y" : 328
      } ]
    } ],
    "catalysts" : [ {
      "id" : 26045,
      "points" : [ {
        "x" : 216,
        "y" : 251
      } ]
    } ]
  }, {
    "id" : 26062,
    "reactomeId" : 10609411,
    "displayName" : "SUMOylation of TOP2B with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 166,
      "y" : 510
    },
    "minX" : 160,
    "maxX" : 172,
    "minY" : 492,
    "maxY" : 533,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 166,
        "y" : 492
      },
      "to" : {
        "x" : 166,
        "y" : 510
      }
    }, {
      "from" : {
        "x" : 166,
        "y" : 510
      },
      "to" : {
        "x" : 167,
        "y" : 533
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 160,
        "y" : 504
      },
      "b" : {
        "x" : 172,
        "y" : 516
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 166,
        "y" : 510
      }
    },
    "inputs" : [ {
      "id" : 26063,
      "points" : [ {
        "x" : 133,
        "y" : 477
      } ]
    }, {
      "id" : 26064,
      "points" : [ {
        "x" : 208,
        "y" : 480
      } ]
    } ],
    "outputs" : [ {
      "id" : 26065,
      "points" : [ {
        "x" : 130,
        "y" : 542
      } ]
    }, {
      "id" : 26066,
      "points" : [ {
        "x" : 215,
        "y" : 542
      } ]
    } ],
    "catalysts" : [ {
      "id" : 26064,
      "points" : [ {
        "x" : 222,
        "y" : 480
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 26067,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 405,
      "y" : 437
    },
    "minX" : 0,
    "maxX" : 810,
    "minY" : 0,
    "maxY" : 875,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 810,
      "height" : 875
    },
    "textPosition" : {
      "x" : 13,
      "y" : 828
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 790,
      "height" : 855
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 26043, 26044, 26046, 26045, 26048, 26049, 26050, 26052, 26053, 26054, 26055, 26057, 26058, 26060, 26061, 26059, 26062, 26063, 26064, 26066, 26047, 26051, 26065, 26056 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 810,
  "minY" : 0,
  "maxY" : 875,
  "disease" : false
}