{ "dbId" : 10649576, "stableId" : "R-DRE-1483249", "displayName" : "Inositol phosphate metabolism", "nodes" : [ { "id" : 98304, "reactomeId" : 10597912, "displayName" : "NUDT(1)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1787, "y" : 1007 }, "minX" : 1746, "maxX" : 1810, "minY" : 989, "maxY" : 1026, "prop" : { "x" : 1765, "y" : 989, "width" : 45, "height" : 37 }, "textPosition" : { "x" : 1766, "y" : 990 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 98300, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1759, "y" : 1004 }, "to" : { "x" : 1754, "y" : 1004 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1750, "y" : 1003 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1750, "y" : 1003 } } } ] }, { "id" : 98307, "reactomeId" : 2023974, "displayName" : "1/3-PP-IP5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1841, "y" : 1254 }, "minX" : 1799, "maxX" : 2004, "minY" : 1207, "maxY" : 1293, "prop" : { "x" : 1799, "y" : 1239, "width" : 85, "height" : 30 }, "textPosition" : { "x" : 1806, "y" : 1243 }, "connectors" : [ { "edgeId" : 98305, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1835, "y" : 1233 }, "to" : { "x" : 1823, "y" : 1207 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1828, "y" : 1228 }, "b" : { "x" : 1835, "y" : 1233 }, "c" : { "x" : 1836, "y" : 1225 }, "type" : "ARROW", "centre" : { "x" : 1836, "y" : 1225 } } }, { "edgeId" : 98310, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98334, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1890, "y" : 1264 }, "to" : { "x" : 2004, "y" : 1293 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98306, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1767, "y" : 1130 }, "minX" : 1746, "maxX" : 1823, "minY" : 1114, "maxY" : 1147, "prop" : { "x" : 1746, "y" : 1115, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1750, "y" : 1119 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1784, "y" : 1120 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1784, "y" : 1120 } } }, "connectors" : [ { "edgeId" : 98305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1792, "y" : 1136 }, "to" : { "x" : 1823, "y" : 1147 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98309, "reactomeId" : 10597912, "displayName" : "NUDT(1)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1762, "y" : 1174 }, "minX" : 1740, "maxX" : 1814, "minY" : 1156, "maxY" : 1193, "prop" : { "x" : 1740, "y" : 1156, "width" : 44, "height" : 37 }, "textPosition" : { "x" : 1741, "y" : 1157 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 98305, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1790, "y" : 1174 }, "to" : { "x" : 1806, "y" : 1175 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1810, "y" : 1175 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1810, "y" : 1175 } } } ] }, { "id" : 98308, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1763, "y" : 1233 }, "minX" : 1748, "maxX" : 1823, "minY" : 1207, "maxY" : 1248, "prop" : { "x" : 1748, "y" : 1218, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 1753, "y" : 1222 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1773, "y" : 1223 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1773, "y" : 1223 } } }, "connectors" : [ { "edgeId" : 98305, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1781, "y" : 1226 }, "to" : { "x" : 1823, "y" : 1207 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1786, "y" : 1220 }, "b" : { "x" : 1781, "y" : 1226 }, "c" : { "x" : 1789, "y" : 1227 }, "type" : "ARROW", "centre" : { "x" : 1789, "y" : 1227 } } } ] }, { "id" : 98311, "reactomeId" : 2023944, "displayName" : "1/3-PP-IP5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1627, "y" : 1254 }, "minX" : 1585, "maxX" : 1670, "minY" : 1239, "maxY" : 1269, "prop" : { "x" : 1585, "y" : 1239, "width" : 85, "height" : 30 }, "textPosition" : { "x" : 1592, "y" : 1243 }, "connectors" : [ { "edgeId" : 98310, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98312, "reactomeId" : 10564682, "displayName" : "Nuclear Pore Complex (NPC)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1692, "y" : 1173 }, "minX" : 1661, "maxX" : 1729, "minY" : 1106, "maxY" : 1246, "prop" : { "x" : 1661, "y" : 1143, "width" : 62, "height" : 60 }, "textPosition" : { "x" : 1660, "y" : 1140 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1723, "y" : 1143 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1723, "y" : 1143 } } }, "connectors" : [ { "edgeId" : 98310, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1694, "y" : 1206 }, "to" : { "x" : 1697, "y" : 1238 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1697, "y" : 1242 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1697, "y" : 1242 } } }, { "edgeId" : 98313, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1694, "y" : 1140 }, "to" : { "x" : 1696, "y" : 1114 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1696, "y" : 1110 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1696, "y" : 1110 } } } ] }, { "id" : 98314, "reactomeId" : 2023936, "displayName" : "(PP)2-IP4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1626, "y" : 1098 }, "minX" : 1590, "maxX" : 1662, "minY" : 1083, "maxY" : 1113, "prop" : { "x" : 1590, "y" : 1083, "width" : 72, "height" : 30 }, "textPosition" : { "x" : 1593, "y" : 1087 }, "connectors" : [ { "edgeId" : 98313, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98317, "reactomeId" : 9668967, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1388, "y" : 1213 }, "minX" : 1368, "maxX" : 1465, "minY" : 1196, "maxY" : 1229, "prop" : { "x" : 1368, "y" : 1197, "width" : 41, "height" : 32 }, "textPosition" : { "x" : 1375, "y" : 1202 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1404, "y" : 1202 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1404, "y" : 1202 } } }, "connectors" : [ { "edgeId" : 98315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1412, "y" : 1211 }, "to" : { "x" : 1465, "y" : 1206 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98316, "reactomeId" : 2023932, "displayName" : "1-PP-IP5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1515, "y" : 1254 }, "minX" : 1465, "maxX" : 1552, "minY" : 1206, "maxY" : 1269, "prop" : { "x" : 1480, "y" : 1239, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 1486, "y" : 1243 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1546, "y" : 1244 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1546, "y" : 1244 } } }, "connectors" : [ { "edgeId" : 98315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1499, "y" : 1236 }, "to" : { "x" : 1465, "y" : 1206 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98319, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1410, "y" : 1098 }, "minX" : 1390, "maxX" : 1467, "minY" : 1082, "maxY" : 1138, "prop" : { "x" : 1390, "y" : 1083, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1394, "y" : 1088 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1426, "y" : 1088 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1426, "y" : 1088 } } }, "connectors" : [ { "edgeId" : 98315, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1434, "y" : 1112 }, "to" : { "x" : 1467, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1442, "y" : 1113 }, "b" : { "x" : 1434, "y" : 1112 }, "c" : { "x" : 1437, "y" : 1119 }, "type" : "ARROW", "centre" : { "x" : 1437, "y" : 1119 } } } ] }, { "id" : 98318, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1433, "y" : 1262 }, "minX" : 1415, "maxX" : 1465, "minY" : 1206, "maxY" : 1277, "prop" : { "x" : 1415, "y" : 1247, "width" : 37, "height" : 30 }, "textPosition" : { "x" : 1418, "y" : 1251 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1447, "y" : 1252 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1447, "y" : 1252 } } }, "connectors" : [ { "edgeId" : 98315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1441, "y" : 1244 }, "to" : { "x" : 1465, "y" : 1206 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98321, "reactomeId" : 10597860, "displayName" : "IP6K1/2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1541, "y" : 1172 }, "minX" : 1474, "maxX" : 1570, "minY" : 1161, "maxY" : 1183, "prop" : { "x" : 1513, "y" : 1161, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1514, "y" : 1161 }, "connectors" : [ { "edgeId" : 98315, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1507, "y" : 1171 }, "to" : { "x" : 1482, "y" : 1171 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1478, "y" : 1171 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1478, "y" : 1171 } } } ] }, { "id" : 98320, "reactomeId" : 2023931, "displayName" : "1,5-(PP)2-IP4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1514, "y" : 1098 }, "minX" : 1462, "maxX" : 1568, "minY" : 1082, "maxY" : 1138, "prop" : { "x" : 1462, "y" : 1083, "width" : 105, "height" : 30 }, "textPosition" : { "x" : 1470, "y" : 1087 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1562, "y" : 1088 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1562, "y" : 1088 } } }, "connectors" : [ { "edgeId" : 98315, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1496, "y" : 1116 }, "to" : { "x" : 1467, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1493, "y" : 1123 }, "b" : { "x" : 1496, "y" : 1116 }, "c" : { "x" : 1488, "y" : 1117 }, "type" : "ARROW", "centre" : { "x" : 1488, "y" : 1117 } } } ] }, { "id" : 98323, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1733, "y" : 903 }, "minX" : 1712, "maxX" : 1765, "minY" : 882, "maxY" : 918, "prop" : { "x" : 1712, "y" : 888, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1716, "y" : 892 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1750, "y" : 893 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1750, "y" : 893 } } }, "connectors" : [ { "edgeId" : 98322, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1758, "y" : 888 }, "to" : { "x" : 1765, "y" : 882 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98325, "reactomeId" : 10597912, "displayName" : "NUDT(1)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1813, "y" : 854 }, "minX" : 1772, "maxX" : 1836, "minY" : 837, "maxY" : 871, "prop" : { "x" : 1790, "y" : 837, "width" : 46, "height" : 34 }, "textPosition" : { "x" : 1792, "y" : 837 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 98322, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1784, "y" : 853 }, "to" : { "x" : 1780, "y" : 853 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1776, "y" : 853 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1776, "y" : 853 } } } ] }, { "id" : 98324, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1725, "y" : 806 }, "minX" : 1710, "maxX" : 1765, "minY" : 790, "maxY" : 828, "prop" : { "x" : 1710, "y" : 791, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 1715, "y" : 795 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1735, "y" : 796 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1735, "y" : 796 } } }, "connectors" : [ { "edgeId" : 98322, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1743, "y" : 814 }, "to" : { "x" : 1765, "y" : 828 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1751, "y" : 814 }, "b" : { "x" : 1743, "y" : 814 }, "c" : { "x" : 1747, "y" : 821 }, "type" : "ARROW", "centre" : { "x" : 1747, "y" : 821 } } } ] }, { "id" : 98327, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1892, "y" : 807 }, "minX" : 1851, "maxX" : 1913, "minY" : 791, "maxY" : 823, "prop" : { "x" : 1872, "y" : 792, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1876, "y" : 796 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1907, "y" : 797 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1907, "y" : 797 } } }, "connectors" : [ { "edgeId" : 98326, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1869, "y" : 814 }, "to" : { "x" : 1851, "y" : 823 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98329, "reactomeId" : 10597865, "displayName" : "ip6k1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1927, "y" : 855 }, "minX" : 1859, "maxX" : 1962, "minY" : 838, "maxY" : 914, "prop" : { "x" : 1899, "y" : 844, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1906, "y" : 844 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1956, "y" : 844 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1956, "y" : 844 } } }, "connectors" : [ { "edgeId" : 98326, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1893, "y" : 854 }, "to" : { "x" : 1867, "y" : 854 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1863, "y" : 854 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1863, "y" : 854 } } }, { "edgeId" : 98330, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1927, "y" : 872 }, "to" : { "x" : 1928, "y" : 906 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1928, "y" : 910 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1928, "y" : 910 } } } ] }, { "id" : 98328, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1890, "y" : 896 }, "minX" : 1852, "maxX" : 1912, "minY" : 880, "maxY" : 911, "prop" : { "x" : 1870, "y" : 881, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1874, "y" : 885 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1906, "y" : 886 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1906, "y" : 886 } } }, "connectors" : [ { "edgeId" : 98326, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1867, "y" : 889 }, "to" : { "x" : 1852, "y" : 884 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1859, "y" : 891 }, "b" : { "x" : 1867, "y" : 889 }, "c" : { "x" : 1862, "y" : 883 }, "type" : "ARROW", "centre" : { "x" : 1862, "y" : 883 } } } ] }, { "id" : 98331, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1873, "y" : 957 }, "minX" : 1853, "maxX" : 1895, "minY" : 922, "maxY" : 972, "prop" : { "x" : 1853, "y" : 942, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1857, "y" : 946 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1888, "y" : 947 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1888, "y" : 947 } } }, "connectors" : [ { "edgeId" : 98330, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1882, "y" : 939 }, "to" : { "x" : 1895, "y" : 922 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98333, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1981, "y" : 961 }, "minX" : 1961, "maxX" : 2003, "minY" : 922, "maxY" : 976, "prop" : { "x" : 1961, "y" : 946, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1965, "y" : 950 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1997, "y" : 951 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1997, "y" : 951 } } }, "connectors" : [ { "edgeId" : 98330, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1973, "y" : 943 }, "to" : { "x" : 1962, "y" : 922 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1966, "y" : 939 }, "b" : { "x" : 1973, "y" : 943 }, "c" : { "x" : 1973, "y" : 935 }, "type" : "ARROW", "centre" : { "x" : 1973, "y" : 935 } } } ] }, { "id" : 98332, "reactomeId" : 1629759, "displayName" : "5-PPP-IP5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2033, "y" : 923 }, "minX" : 1962, "maxX" : 2073, "minY" : 907, "maxY" : 938, "prop" : { "x" : 1994, "y" : 908, "width" : 78, "height" : 30 }, "textPosition" : { "x" : 1999, "y" : 912 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2067, "y" : 913 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2067, "y" : 913 } } }, "connectors" : [ { "edgeId" : 98330, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1991, "y" : 922 }, "to" : { "x" : 1962, "y" : 922 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1984, "y" : 926 }, "b" : { "x" : 1991, "y" : 922 }, "c" : { "x" : 1984, "y" : 918 }, "type" : "ARROW", "centre" : { "x" : 1984, "y" : 918 } } } ] }, { "id" : 98335, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1943, "y" : 1327 }, "minX" : 1922, "maxX" : 2004, "minY" : 1293, "maxY" : 1342, "prop" : { "x" : 1922, "y" : 1312, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1926, "y" : 1316 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1960, "y" : 1317 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1960, "y" : 1317 } } }, "connectors" : [ { "edgeId" : 98334, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1968, "y" : 1315 }, "to" : { "x" : 2004, "y" : 1293 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98337, "reactomeId" : 10597912, "displayName" : "NUDT(1)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2166, "y" : 1007 }, "minX" : 2121, "maxX" : 2188, "minY" : 990, "maxY" : 1024, "prop" : { "x" : 2144, "y" : 990, "width" : 44, "height" : 34 }, "textPosition" : { "x" : 2145, "y" : 990 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 98334, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2138, "y" : 1007 }, "to" : { "x" : 2129, "y" : 1007 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2125, "y" : 1007 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2125, "y" : 1007 } } } ] }, { "id" : 98336, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1884, "y" : 757 }, "minX" : 1869, "maxX" : 1942, "minY" : 741, "maxY" : 772, "prop" : { "x" : 1869, "y" : 742, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 1874, "y" : 746 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1894, "y" : 747 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1894, "y" : 747 } } }, "connectors" : [ { "edgeId" : 98334, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1902, "y" : 759 }, "to" : { "x" : 1942, "y" : 768 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1910, "y" : 757 }, "b" : { "x" : 1902, "y" : 759 }, "c" : { "x" : 1908, "y" : 764 }, "type" : "ARROW", "centre" : { "x" : 1908, "y" : 764 } } } ] }, { "id" : 98339, "reactomeId" : 994141, "displayName" : "I(1,3,4,5,6)P5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1797, "y" : 624 }, "minX" : 1748, "maxX" : 1905, "minY" : 554, "maxY" : 668, "prop" : { "x" : 1748, "y" : 609, "width" : 99, "height" : 30 }, "textPosition" : { "x" : 1751, "y" : 613 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1842, "y" : 614 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1842, "y" : 614 } } }, "connectors" : [ { "edgeId" : 98338, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98349, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1790, "y" : 642 }, "to" : { "x" : 1779, "y" : 668 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98353, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1810, "y" : 606 }, "to" : { "x" : 1847, "y" : 570 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1812, "y" : 598 }, "b" : { "x" : 1810, "y" : 606 }, "c" : { "x" : 1818, "y" : 604 }, "type" : "ARROW", "centre" : { "x" : 1818, "y" : 604 } } }, { "edgeId" : 98358, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1793, "y" : 606 }, "to" : { "x" : 1781, "y" : 554 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98362, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1838, "y" : 606 }, "to" : { "x" : 1905, "y" : 585 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98367, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1850, "y" : 614 }, "to" : { "x" : 1898, "y" : 605 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1856, "y" : 609 }, "b" : { "x" : 1850, "y" : 614 }, "c" : { "x" : 1858, "y" : 617 }, "type" : "ARROW", "centre" : { "x" : 1858, "y" : 617 } } } ] }, { "id" : 98340, "reactomeId" : 10564682, "displayName" : "Nuclear Pore Complex (NPC)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1678, "y" : 480 }, "minX" : 1648, "maxX" : 1715, "minY" : 401, "maxY" : 612, "prop" : { "x" : 1648, "y" : 450, "width" : 61, "height" : 61 }, "textPosition" : { "x" : 1647, "y" : 448 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1709, "y" : 450 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1709, "y" : 450 } } }, "connectors" : [ { "edgeId" : 98338, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1681, "y" : 514 }, "to" : { "x" : 1693, "y" : 604 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1693, "y" : 608 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1693, "y" : 608 } } }, { "edgeId" : 98341, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1684, "y" : 447 }, "to" : { "x" : 1693, "y" : 409 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1694, "y" : 405 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1694, "y" : 405 } } } ] }, { "id" : 98342, "reactomeId" : 1629755, "displayName" : "5-PP-IP4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1781, "y" : 393 }, "minX" : 1746, "maxX" : 1818, "minY" : 377, "maxY" : 458, "prop" : { "x" : 1746, "y" : 378, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 1752, "y" : 382 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1812, "y" : 383 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1812, "y" : 383 } } }, "connectors" : [ { "edgeId" : 98341, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98358, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1780, "y" : 411 }, "to" : { "x" : 1780, "y" : 458 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1784, "y" : 418 }, "b" : { "x" : 1780, "y" : 411 }, "c" : { "x" : 1776, "y" : 418 }, "type" : "ARROW", "centre" : { "x" : 1776, "y" : 418 } } } ] }, { "id" : 98345, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1737, "y" : 340 }, "minX" : 1719, "maxX" : 1772, "minY" : 308, "maxY" : 355, "prop" : { "x" : 1719, "y" : 325, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1721, "y" : 329 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1750, "y" : 330 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1750, "y" : 330 } } }, "connectors" : [ { "edgeId" : 98343, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1753, "y" : 322 }, "to" : { "x" : 1772, "y" : 308 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98344, "reactomeId" : 1629736, "displayName" : "1-PP-IP4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1845, "y" : 352 }, "minX" : 1772, "maxX" : 1881, "minY" : 308, "maxY" : 367, "prop" : { "x" : 1811, "y" : 337, "width" : 69, "height" : 30 }, "textPosition" : { "x" : 1816, "y" : 341 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1875, "y" : 342 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1875, "y" : 342 } } }, "connectors" : [ { "edgeId" : 98343, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1820, "y" : 334 }, "to" : { "x" : 1772, "y" : 308 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98347, "reactomeId" : 1629738, "displayName" : "1,5-(PP)2-IP3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1835, "y" : 200 }, "minX" : 1773, "maxX" : 1887, "minY" : 184, "maxY" : 241, "prop" : { "x" : 1785, "y" : 185, "width" : 101, "height" : 30 }, "textPosition" : { "x" : 1791, "y" : 189 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1881, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1881, "y" : 190 } } }, "connectors" : [ { "edgeId" : 98343, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1812, "y" : 218 }, "to" : { "x" : 1773, "y" : 241 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1808, "y" : 225 }, "b" : { "x" : 1812, "y" : 218 }, "c" : { "x" : 1804, "y" : 218 }, "type" : "ARROW", "centre" : { "x" : 1804, "y" : 218 } } } ] }, { "id" : 98346, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1745, "y" : 202 }, "minX" : 1725, "maxX" : 1773, "minY" : 186, "maxY" : 241, "prop" : { "x" : 1725, "y" : 187, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1728, "y" : 191 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1760, "y" : 192 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1760, "y" : 192 } } }, "connectors" : [ { "edgeId" : 98343, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1755, "y" : 220 }, "to" : { "x" : 1773, "y" : 241 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1763, "y" : 223 }, "b" : { "x" : 1755, "y" : 220 }, "c" : { "x" : 1756, "y" : 228 }, "type" : "ARROW", "centre" : { "x" : 1756, "y" : 228 } } } ] }, { "id" : 98348, "reactomeId" : 10597865, "displayName" : "ip6k1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1833, "y" : 267 }, "minX" : 1780, "maxX" : 1868, "minY" : 250, "maxY" : 278, "prop" : { "x" : 1805, "y" : 256, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1812, "y" : 256 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1862, "y" : 256 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1862, "y" : 256 } } }, "connectors" : [ { "edgeId" : 98343, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1799, "y" : 267 }, "to" : { "x" : 1788, "y" : 268 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1784, "y" : 268 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1784, "y" : 268 } } } ] }, { "id" : 98351, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1724, "y" : 756 }, "minX" : 1704, "maxX" : 1779, "minY" : 731, "maxY" : 771, "prop" : { "x" : 1704, "y" : 741, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1708, "y" : 745 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1740, "y" : 746 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1740, "y" : 746 } } }, "connectors" : [ { "edgeId" : 98349, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1748, "y" : 746 }, "to" : { "x" : 1779, "y" : 731 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1752, "y" : 739 }, "b" : { "x" : 1748, "y" : 746 }, "c" : { "x" : 1756, "y" : 747 }, "type" : "ARROW", "centre" : { "x" : 1756, "y" : 747 } } } ] }, { "id" : 98350, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1726, "y" : 650 }, "minX" : 1706, "maxX" : 1779, "minY" : 634, "maxY" : 668, "prop" : { "x" : 1706, "y" : 635, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1710, "y" : 639 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1741, "y" : 640 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1741, "y" : 640 } } }, "connectors" : [ { "edgeId" : 98349, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1749, "y" : 656 }, "to" : { "x" : 1779, "y" : 668 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98352, "reactomeId" : 10597948, "displayName" : "ippk", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1725, "y" : 696 }, "minX" : 1708, "maxX" : 1770, "minY" : 679, "maxY" : 707, "prop" : { "x" : 1708, "y" : 685, "width" : 34, "height" : 22 }, "textPosition" : { "x" : 1708, "y" : 685 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1742, "y" : 685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1742, "y" : 685 } } }, "connectors" : [ { "edgeId" : 98349, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1745, "y" : 695 }, "to" : { "x" : 1762, "y" : 695 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1766, "y" : 695 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1766, "y" : 695 } } } ] }, { "id" : 98355, "reactomeId" : 2023943, "displayName" : "PP-IP4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1847, "y" : 432 }, "minX" : 1819, "maxX" : 1875, "minY" : 417, "maxY" : 471, "prop" : { "x" : 1819, "y" : 417, "width" : 56, "height" : 30 }, "textPosition" : { "x" : 1823, "y" : 421 }, "connectors" : [ { "edgeId" : 98353, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1846, "y" : 453 }, "to" : { "x" : 1846, "y" : 471 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98354, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1917, "y" : 431 }, "minX" : 1846, "maxX" : 1940, "minY" : 415, "maxY" : 471, "prop" : { "x" : 1896, "y" : 416, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1900, "y" : 420 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1934, "y" : 421 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1934, "y" : 421 } } }, "connectors" : [ { "edgeId" : 98353, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1893, "y" : 443 }, "to" : { "x" : 1846, "y" : 471 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98357, "reactomeId" : 10597900, "displayName" : "NUDT4:Mg2+/Mn2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1937, "y" : 478 }, "minX" : 1854, "maxX" : 1985, "minY" : 456, "maxY" : 505, "prop" : { "x" : 1895, "y" : 462, "width" : 84, "height" : 33 }, "textPosition" : { "x" : 1895, "y" : 460 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1979, "y" : 462 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1979, "y" : 462 } } }, "connectors" : [ { "edgeId" : 98353, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1892, "y" : 490 }, "to" : { "x" : 1862, "y" : 500 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1858, "y" : 501 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1858, "y" : 501 } } } ] }, { "id" : 98356, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1817, "y" : 532 }, "minX" : 1802, "maxX" : 1847, "minY" : 516, "maxY" : 570, "prop" : { "x" : 1802, "y" : 517, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 1807, "y" : 521 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1827, "y" : 522 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1827, "y" : 522 } } }, "connectors" : [ { "edgeId" : 98353, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1828, "y" : 550 }, "to" : { "x" : 1847, "y" : 570 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1836, "y" : 552 }, "b" : { "x" : 1828, "y" : 550 }, "c" : { "x" : 1830, "y" : 558 }, "type" : "ARROW", "centre" : { "x" : 1830, "y" : 558 } } } ] }, { "id" : 98359, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1737, "y" : 596 }, "minX" : 1717, "maxX" : 1781, "minY" : 554, "maxY" : 611, "prop" : { "x" : 1717, "y" : 581, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1721, "y" : 585 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1752, "y" : 586 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1752, "y" : 586 } } }, "connectors" : [ { "edgeId" : 98358, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1752, "y" : 578 }, "to" : { "x" : 1781, "y" : 554 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98361, "reactomeId" : 10597865, "displayName" : "ip6k1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1740, "y" : 540 }, "minX" : 1712, "maxX" : 1784, "minY" : 506, "maxY" : 551, "prop" : { "x" : 1712, "y" : 529, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1719, "y" : 529 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1769, "y" : 529 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1769, "y" : 529 } } }, "connectors" : [ { "edgeId" : 98358, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1756, "y" : 523 }, "to" : { "x" : 1777, "y" : 512 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1780, "y" : 510 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1780, "y" : 510 } } } ] }, { "id" : 98360, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1739, "y" : 429 }, "minX" : 1718, "maxX" : 1780, "minY" : 413, "maxY" : 458, "prop" : { "x" : 1718, "y" : 414, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1722, "y" : 418 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1755, "y" : 419 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1755, "y" : 419 } } }, "connectors" : [ { "edgeId" : 98358, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1763, "y" : 443 }, "to" : { "x" : 1780, "y" : 458 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1771, "y" : 445 }, "b" : { "x" : 1763, "y" : 443 }, "c" : { "x" : 1766, "y" : 451 }, "type" : "ARROW", "centre" : { "x" : 1766, "y" : 451 } } } ] }, { "id" : 98363, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1901, "y" : 528 }, "minX" : 1880, "maxX" : 1924, "minY" : 512, "maxY" : 585, "prop" : { "x" : 1880, "y" : 513, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1884, "y" : 517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1918, "y" : 518 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1918, "y" : 518 } } }, "connectors" : [ { "edgeId" : 98362, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1902, "y" : 546 }, "to" : { "x" : 1905, "y" : 585 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98365, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2019, "y" : 566 }, "minX" : 1985, "maxX" : 2035, "minY" : 550, "maxY" : 586, "prop" : { "x" : 2004, "y" : 551, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 2009, "y" : 555 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2029, "y" : 556 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2029, "y" : 556 } } }, "connectors" : [ { "edgeId" : 98362, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2001, "y" : 574 }, "to" : { "x" : 1985, "y" : 586 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1998, "y" : 581 }, "b" : { "x" : 2001, "y" : 574 }, "c" : { "x" : 1993, "y" : 575 }, "type" : "ARROW", "centre" : { "x" : 1993, "y" : 575 } } } ] }, { "id" : 98364, "reactomeId" : 994149, "displayName" : "I(3,4,5,6)P4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2016, "y" : 619 }, "minX" : 1946, "maxX" : 2061, "minY" : 586, "maxY" : 634, "prop" : { "x" : 1973, "y" : 604, "width" : 87, "height" : 30 }, "textPosition" : { "x" : 1976, "y" : 608 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2055, "y" : 609 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2055, "y" : 609 } } }, "connectors" : [ { "edgeId" : 98362, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2001, "y" : 601 }, "to" : { "x" : 1985, "y" : 586 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1993, "y" : 599 }, "b" : { "x" : 2001, "y" : 601 }, "c" : { "x" : 1999, "y" : 593 }, "type" : "ARROW", "centre" : { "x" : 1999, "y" : 593 } } }, { "edgeId" : 98367, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1970, "y" : 610 }, "to" : { "x" : 1946, "y" : 605 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98366, "reactomeId" : 10597872, "displayName" : "ITPK1:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1980, "y" : 520 }, "minX" : 1921, "maxX" : 2027, "minY" : 503, "maxY" : 599, "prop" : { "x" : 1939, "y" : 509, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 1939, "y" : 510 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2021, "y" : 509 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2021, "y" : 509 } } }, "connectors" : [ { "edgeId" : 98362, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1974, "y" : 534 }, "to" : { "x" : 1957, "y" : 571 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1955, "y" : 574 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1955, "y" : 574 } } }, { "edgeId" : 98367, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1971, "y" : 534 }, "to" : { "x" : 1928, "y" : 592 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1925, "y" : 595 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1925, "y" : 595 } } } ] }, { "id" : 98369, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1865, "y" : 649 }, "minX" : 1845, "maxX" : 1898, "minY" : 605, "maxY" : 664, "prop" : { "x" : 1845, "y" : 634, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1849, "y" : 638 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1881, "y" : 639 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1881, "y" : 639 } } }, "connectors" : [ { "edgeId" : 98367, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1876, "y" : 631 }, "to" : { "x" : 1898, "y" : 605 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1877, "y" : 623 }, "b" : { "x" : 1876, "y" : 631 }, "c" : { "x" : 1884, "y" : 628 }, "type" : "ARROW", "centre" : { "x" : 1884, "y" : 628 } } } ] }, { "id" : 98368, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1944, "y" : 649 }, "minX" : 1924, "maxX" : 1965, "minY" : 605, "maxY" : 664, "prop" : { "x" : 1924, "y" : 634, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1928, "y" : 638 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1959, "y" : 639 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1959, "y" : 639 } } }, "connectors" : [ { "edgeId" : 98367, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1944, "y" : 631 }, "to" : { "x" : 1946, "y" : 605 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98371, "reactomeId" : 2024008, "displayName" : "I(1,3,4,5,6)P5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2273, "y" : 590 }, "minX" : 2225, "maxX" : 2322, "minY" : 574, "maxY" : 635, "prop" : { "x" : 2225, "y" : 575, "width" : 96, "height" : 31 }, "textPosition" : { "x" : 2226, "y" : 580 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2316, "y" : 580 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2316, "y" : 580 } } }, "connectors" : [ { "edgeId" : 98370, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2283, "y" : 609 }, "to" : { "x" : 2303, "y" : 635 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98373, "reactomeId" : 2024012, "displayName" : "I(1,4,5,6)P4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2325, "y" : 792 }, "minX" : 2282, "maxX" : 2370, "minY" : 738, "maxY" : 807, "prop" : { "x" : 2282, "y" : 777, "width" : 87, "height" : 30 }, "textPosition" : { "x" : 2285, "y" : 781 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2364, "y" : 782 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2364, "y" : 782 } } }, "connectors" : [ { "edgeId" : 98370, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2318, "y" : 774 }, "to" : { "x" : 2302, "y" : 738 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2312, "y" : 769 }, "b" : { "x" : 2318, "y" : 774 }, "c" : { "x" : 2319, "y" : 766 }, "type" : "ARROW", "centre" : { "x" : 2319, "y" : 766 } } } ] }, { "id" : 98372, "reactomeId" : 113519, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2356, "y" : 599 }, "minX" : 2303, "maxX" : 2376, "minY" : 583, "maxY" : 635, "prop" : { "x" : 2337, "y" : 584, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 2339, "y" : 588 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2370, "y" : 589 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2370, "y" : 589 } } }, "connectors" : [ { "edgeId" : 98370, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2334, "y" : 611 }, "to" : { "x" : 2303, "y" : 635 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98375, "reactomeId" : 10597885, "displayName" : "minpp1b", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2246, "y" : 695 }, "minX" : 2171, "maxX" : 2294, "minY" : 678, "maxY" : 720, "prop" : { "x" : 2220, "y" : 684, "width" : 53, "height" : 22 }, "textPosition" : { "x" : 2223, "y" : 678 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2273, "y" : 684 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2273, "y" : 684 } } }, "connectors" : [ { "edgeId" : 98370, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2276, "y" : 695 }, "to" : { "x" : 2286, "y" : 695 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2290, "y" : 696 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2290, "y" : 696 } } }, { "edgeId" : 98376, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2217, "y" : 703 }, "to" : { "x" : 2179, "y" : 715 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2175, "y" : 716 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2175, "y" : 716 } } } ] }, { "id" : 98374, "reactomeId" : 113551, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2262, "y" : 768 }, "minX" : 2249, "maxX" : 2302, "minY" : 738, "maxY" : 783, "prop" : { "x" : 2249, "y" : 753, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 2253, "y" : 757 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2271, "y" : 758 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2271, "y" : 758 } } }, "connectors" : [ { "edgeId" : 98370, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2279, "y" : 757 }, "to" : { "x" : 2302, "y" : 738 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2282, "y" : 750 }, "b" : { "x" : 2279, "y" : 757 }, "c" : { "x" : 2287, "y" : 756 }, "type" : "ARROW", "centre" : { "x" : 2287, "y" : 756 } } } ] }, { "id" : 98377, "reactomeId" : 2024018, "displayName" : "IP6", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2163, "y" : 794 }, "minX" : 2146, "maxX" : 2182, "minY" : 750, "maxY" : 809, "prop" : { "x" : 2146, "y" : 779, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 2150, "y" : 783 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2176, "y" : 784 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2176, "y" : 784 } } }, "connectors" : [ { "edgeId" : 98376, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2163, "y" : 776 }, "to" : { "x" : 2163, "y" : 750 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98379, "reactomeId" : 2564836, "displayName" : "I(1,2,4,5,6)P5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2196, "y" : 636 }, "minX" : 2149, "maxX" : 2244, "minY" : 619, "maxY" : 683, "prop" : { "x" : 2149, "y" : 620, "width" : 94, "height" : 32 }, "textPosition" : { "x" : 2149, "y" : 625 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2238, "y" : 625 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2238, "y" : 625 } } }, "connectors" : [ { "edgeId" : 98376, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2185, "y" : 655 }, "to" : { "x" : 2165, "y" : 683 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2184, "y" : 663 }, "b" : { "x" : 2185, "y" : 655 }, "c" : { "x" : 2178, "y" : 658 }, "type" : "ARROW", "centre" : { "x" : 2178, "y" : 658 } } } ] }, { "id" : 98378, "reactomeId" : 113519, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2205, "y" : 768 }, "minX" : 2163, "maxX" : 2225, "minY" : 750, "maxY" : 783, "prop" : { "x" : 2186, "y" : 753, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 2188, "y" : 757 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2219, "y" : 758 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2219, "y" : 758 } } }, "connectors" : [ { "edgeId" : 98376, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2183, "y" : 759 }, "to" : { "x" : 2163, "y" : 750 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98380, "reactomeId" : 113551, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2124, "y" : 660 }, "minX" : 2111, "maxX" : 2165, "minY" : 644, "maxY" : 683, "prop" : { "x" : 2111, "y" : 645, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 2115, "y" : 649 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2133, "y" : 650 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2133, "y" : 650 } } }, "connectors" : [ { "edgeId" : 98376, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2141, "y" : 667 }, "to" : { "x" : 2165, "y" : 683 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2149, "y" : 668 }, "b" : { "x" : 2141, "y" : 667 }, "c" : { "x" : 2145, "y" : 674 }, "type" : "ARROW", "centre" : { "x" : 2145, "y" : 674 } } } ] }, { "id" : 98383, "reactomeId" : 2162232, "displayName" : "GlcA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 130, "y" : 843 }, "minX" : 108, "maxX" : 153, "minY" : 771, "maxY" : 858, "prop" : { "x" : 108, "y" : 828, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 112, "y" : 832 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 147, "y" : 833 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 147, "y" : 833 } } }, "connectors" : [ { "edgeId" : 98381, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 129, "y" : 825 }, "to" : { "x" : 129, "y" : 771 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 125, "y" : 818 }, "b" : { "x" : 129, "y" : 825 }, "c" : { "x" : 133, "y" : 818 }, "type" : "ARROW", "centre" : { "x" : 133, "y" : 818 } } } ] }, { "id" : 98382, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 86, "y" : 659 }, "minX" : 70, "maxX" : 129, "minY" : 643, "maxY" : 703, "prop" : { "x" : 70, "y" : 644, "width" : 32, "height" : 30 }, "textPosition" : { "x" : 73, "y" : 648 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 97, "y" : 649 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 97, "y" : 649 } } }, "connectors" : [ { "edgeId" : 98381, "type" : "INPUT", "segments" : [ { "from" : { "x" : 100, "y" : 677 }, "to" : { "x" : 129, "y" : 703 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98385, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 212, "y" : 758 }, "minX" : 129, "maxX" : 226, "minY" : 745, "maxY" : 771, "prop" : { "x" : 200, "y" : 746, "width" : 25, "height" : 24 }, "textPosition" : { "x" : 203, "y" : 741 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 220, "y" : 751 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 220, "y" : 751 } } }, "connectors" : [ { "edgeId" : 98381, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 197, "y" : 759 }, "to" : { "x" : 129, "y" : 771 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 191, "y" : 764 }, "b" : { "x" : 197, "y" : 759 }, "c" : { "x" : 189, "y" : 756 }, "type" : "ARROW", "centre" : { "x" : 189, "y" : 756 } } } ], "trivial" : true }, { "id" : 98384, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 180, "y" : 797 }, "minX" : 129, "maxX" : 200, "minY" : 771, "maxY" : 813, "prop" : { "x" : 161, "y" : 782, "width" : 38, "height" : 31 }, "textPosition" : { "x" : 163, "y" : 787 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 194, "y" : 787 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 194, "y" : 787 } } }, "connectors" : [ { "edgeId" : 98381, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 158, "y" : 787 }, "to" : { "x" : 129, "y" : 771 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 150, "y" : 787 }, "b" : { "x" : 158, "y" : 787 }, "c" : { "x" : 154, "y" : 780 }, "type" : "ARROW", "centre" : { "x" : 154, "y" : 780 } } } ], "trivial" : true }, { "id" : 98386, "reactomeId" : 10616541, "displayName" : "MIOX:2xFe2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 71, "y" : 740 }, "minX" : 44, "maxX" : 121, "minY" : 718, "maxY" : 757, "prop" : { "x" : 44, "y" : 724, "width" : 54, "height" : 33 }, "textPosition" : { "x" : 48, "y" : 708 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 98, "y" : 724 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 98, "y" : 724 } } }, "connectors" : [ { "edgeId" : 98381, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 101, "y" : 740 }, "to" : { "x" : 113, "y" : 740 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 117, "y" : 740 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 117, "y" : 740 } } } ] }, { "id" : 98394, "reactomeId" : 10647980, "displayName" : "DAG and IP3 signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 805, "y" : 106 }, "minX" : 721, "maxX" : 889, "minY" : 79, "maxY" : 133, "prop" : { "x" : 721, "y" : 79, "width" : 168, "height" : 54 }, "textPosition" : { "x" : 728, "y" : 91 }, "connectors" : [ ] }, { "id" : 98400, "reactomeId" : 10648404, "displayName" : "Glycosaminoglycan metabolism", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 130, "y" : 966 }, "minX" : 55, "maxX" : 206, "minY" : 929, "maxY" : 1003, "prop" : { "x" : 55, "y" : 929, "width" : 151, "height" : 74 }, "textPosition" : { "x" : 61, "y" : 944 }, "connectors" : [ ] }, { "id" : 98151, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 498, "y" : 115 }, "minX" : 478, "maxX" : 524, "minY" : 67, "maxY" : 130, "prop" : { "x" : 478, "y" : 100, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 481, "y" : 104 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 514, "y" : 105 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 514, "y" : 105 } } }, "connectors" : [ { "edgeId" : 98149, "type" : "INPUT", "segments" : [ { "from" : { "x" : 506, "y" : 97 }, "to" : { "x" : 524, "y" : 67 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98156, "type" : "INPUT", "segments" : [ { "from" : { "x" : 500, "y" : 97 }, "to" : { "x" : 503, "y" : 79 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98150, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 481, "y" : 19 }, "minX" : 449, "maxX" : 524, "minY" : 3, "maxY" : 79, "prop" : { "x" : 449, "y" : 4, "width" : 65, "height" : 30 }, "textPosition" : { "x" : 449, "y" : 8 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 509, "y" : 9 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 509, "y" : 9 } } }, "connectors" : [ { "edgeId" : 98149, "type" : "INPUT", "segments" : [ { "from" : { "x" : 494, "y" : 37 }, "to" : { "x" : 524, "y" : 67 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98156, "type" : "INPUT", "segments" : [ { "from" : { "x" : 486, "y" : 37 }, "to" : { "x" : 503, "y" : 79 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98153, "reactomeId" : 114520, "displayName" : "I(1,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 681, "y" : 198 }, "minX" : 586, "maxX" : 801, "minY" : 68, "maxY" : 253, "prop" : { "x" : 646, "y" : 183, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 647, "y" : 187 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 712, "y" : 188 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 712, "y" : 188 } } }, "connectors" : [ { "edgeId" : 98176, "type" : "INPUT", "segments" : [ { "from" : { "x" : 643, "y" : 204 }, "to" : { "x" : 586, "y" : 216 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98181, "type" : "INPUT", "segments" : [ { "from" : { "x" : 643, "y" : 200 }, "to" : { "x" : 603, "y" : 203 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98208, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 720, "y" : 204 }, "to" : { "x" : 801, "y" : 221 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 728, "y" : 202 }, "b" : { "x" : 720, "y" : 204 }, "c" : { "x" : 726, "y" : 209 }, "type" : "ARROW", "centre" : { "x" : 726, "y" : 209 } } }, { "edgeId" : 98239, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98149, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 671, "y" : 180 }, "to" : { "x" : 599, "y" : 68 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 664, "y" : 176 }, "b" : { "x" : 671, "y" : 180 }, "c" : { "x" : 671, "y" : 172 }, "type" : "ARROW", "centre" : { "x" : 671, "y" : 172 } } }, { "edgeId" : 98156, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 670, "y" : 180 }, "to" : { "x" : 601, "y" : 87 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 663, "y" : 177 }, "b" : { "x" : 670, "y" : 180 }, "c" : { "x" : 669, "y" : 172 }, "type" : "ARROW", "centre" : { "x" : 669, "y" : 172 } } }, { "edgeId" : 98158, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 658, "y" : 216 }, "to" : { "x" : 599, "y" : 253 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 654, "y" : 223 }, "b" : { "x" : 658, "y" : 216 }, "c" : { "x" : 650, "y" : 216 }, "type" : "ARROW", "centre" : { "x" : 650, "y" : 216 } } } ] }, { "id" : 98152, "reactomeId" : 114519, "displayName" : "DAG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 644, "y" : 21 }, "minX" : 599, "maxX" : 666, "minY" : 6, "maxY" : 87, "prop" : { "x" : 624, "y" : 7, "width" : 41, "height" : 29 }, "textPosition" : { "x" : 627, "y" : 11 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 660, "y" : 12 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 660, "y" : 12 } } }, "connectors" : [ { "edgeId" : 98149, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 630, "y" : 39 }, "to" : { "x" : 599, "y" : 68 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 628, "y" : 47 }, "b" : { "x" : 630, "y" : 39 }, "c" : { "x" : 622, "y" : 41 }, "type" : "ARROW", "centre" : { "x" : 622, "y" : 41 } } }, { "edgeId" : 98156, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 634, "y" : 39 }, "to" : { "x" : 601, "y" : 87 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 633, "y" : 47 }, "b" : { "x" : 634, "y" : 39 }, "c" : { "x" : 627, "y" : 42 }, "type" : "ARROW", "centre" : { "x" : 627, "y" : 42 } } } ] }, { "id" : 98155, "reactomeId" : 10598053, "displayName" : "PLCdegh", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 563, "y" : 13 }, "minX" : 534, "maxX" : 592, "minY" : 2, "maxY" : 59, "prop" : { "x" : 534, "y" : 2, "width" : 58, "height" : 23 }, "textPosition" : { "x" : 536, "y" : -4 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 98149, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 563, "y" : 31 }, "to" : { "x" : 564, "y" : 51 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 564, "y" : 55 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 564, "y" : 55 } } } ] }, { "id" : 98154, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 660, "y" : 79 }, "minX" : 599, "maxX" : 680, "minY" : 64, "maxY" : 94, "prop" : { "x" : 642, "y" : 65, "width" : 37, "height" : 29 }, "textPosition" : { "x" : 647, "y" : 69 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 674, "y" : 70 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 674, "y" : 70 } } }, "connectors" : [ { "edgeId" : 98149, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 639, "y" : 75 }, "to" : { "x" : 599, "y" : 68 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 631, "y" : 78 }, "b" : { "x" : 639, "y" : 75 }, "c" : { "x" : 633, "y" : 70 }, "type" : "ARROW", "centre" : { "x" : 633, "y" : 70 } } }, { "edgeId" : 98156, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 639, "y" : 81 }, "to" : { "x" : 601, "y" : 87 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 633, "y" : 86 }, "b" : { "x" : 639, "y" : 81 }, "c" : { "x" : 632, "y" : 78 }, "type" : "ARROW", "centre" : { "x" : 632, "y" : 78 } } } ], "trivial" : true }, { "id" : 98157, "reactomeId" : 10597943, "displayName" : "PLCB3:Ca2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 563, "y" : 135 }, "minX" : 540, "maxX" : 592, "minY" : 94, "maxY" : 146, "prop" : { "x" : 540, "y" : 125, "width" : 46, "height" : 21 }, "textPosition" : { "x" : 540, "y" : 118 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 586, "y" : 125 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 586, "y" : 125 } } }, "connectors" : [ { "edgeId" : 98156, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 563, "y" : 119 }, "to" : { "x" : 563, "y" : 102 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 563, "y" : 98 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 563, "y" : 98 } } } ] }, { "id" : 98159, "reactomeId" : 2023856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 482, "y" : 310 }, "minX" : 447, "maxX" : 529, "minY" : 254, "maxY" : 325, "prop" : { "x" : 447, "y" : 295, "width" : 70, "height" : 30 }, "textPosition" : { "x" : 449, "y" : 299 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 512, "y" : 300 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 512, "y" : 300 } } }, "connectors" : [ { "edgeId" : 98158, "type" : "INPUT", "segments" : [ { "from" : { "x" : 494, "y" : 292 }, "to" : { "x" : 529, "y" : 254 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98161, "reactomeId" : 1500596, "displayName" : "DAG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 637, "y" : 310 }, "minX" : 599, "maxX" : 660, "minY" : 253, "maxY" : 325, "prop" : { "x" : 616, "y" : 295, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 620, "y" : 299 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 654, "y" : 300 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 654, "y" : 300 } } }, "connectors" : [ { "edgeId" : 98158, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 627, "y" : 292 }, "to" : { "x" : 599, "y" : 253 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 620, "y" : 289 }, "b" : { "x" : 627, "y" : 292 }, "c" : { "x" : 626, "y" : 284 }, "type" : "ARROW", "centre" : { "x" : 626, "y" : 284 } } } ] }, { "id" : 98160, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 459, "y" : 254 }, "minX" : 439, "maxX" : 529, "minY" : 238, "maxY" : 269, "prop" : { "x" : 439, "y" : 239, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 442, "y" : 243 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 475, "y" : 244 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 475, "y" : 244 } } }, "connectors" : [ { "edgeId" : 98158, "type" : "INPUT", "segments" : [ { "from" : { "x" : 483, "y" : 254 }, "to" : { "x" : 529, "y" : 254 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98163, "reactomeId" : 10598024, "displayName" : "PLCD4:3xCa2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 489, "y" : 373 }, "minX" : 436, "maxX" : 567, "minY" : 260, "maxY" : 384, "prop" : { "x" : 436, "y" : 362, "width" : 107, "height" : 22 }, "textPosition" : { "x" : 440, "y" : 362 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 543, "y" : 362 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 543, "y" : 362 } } }, "connectors" : [ { "edgeId" : 98158, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 496, "y" : 356 }, "to" : { "x" : 561, "y" : 267 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 563, "y" : 264 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 563, "y" : 264 } } } ] }, { "id" : 98162, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 648, "y" : 259 }, "minX" : 599, "maxX" : 667, "minY" : 246, "maxY" : 272, "prop" : { "x" : 630, "y" : 247, "width" : 36, "height" : 25 }, "textPosition" : { "x" : 634, "y" : 249 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 661, "y" : 252 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 661, "y" : 252 } } }, "connectors" : [ { "edgeId" : 98158, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 627, "y" : 256 }, "to" : { "x" : 599, "y" : 253 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 620, "y" : 259 }, "b" : { "x" : 627, "y" : 256 }, "c" : { "x" : 621, "y" : 251 }, "type" : "ARROW", "centre" : { "x" : 621, "y" : 251 } } } ], "trivial" : true }, { "id" : 98165, "reactomeId" : 113519, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 537, "y" : 465 }, "minX" : 519, "maxX" : 641, "minY" : 427, "maxY" : 481, "prop" : { "x" : 519, "y" : 450, "width" : 37, "height" : 31 }, "textPosition" : { "x" : 520, "y" : 455 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 551, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 551, "y" : 455 } } }, "connectors" : [ { "edgeId" : 98164, "type" : "INPUT", "segments" : [ { "from" : { "x" : 559, "y" : 458 }, "to" : { "x" : 641, "y" : 427 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98167, "reactomeId" : 2024016, "displayName" : "I(1,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 681, "y" : 345 }, "minX" : 641, "maxX" : 720, "minY" : 329, "maxY" : 372, "prop" : { "x" : 644, "y" : 330, "width" : 75, "height" : 30 }, "textPosition" : { "x" : 647, "y" : 334 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 714, "y" : 335 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 714, "y" : 335 } } }, "connectors" : [ { "edgeId" : 98164, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 658, "y" : 363 }, "to" : { "x" : 641, "y" : 372 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 654, "y" : 370 }, "b" : { "x" : 658, "y" : 363 }, "c" : { "x" : 650, "y" : 363 }, "type" : "ARROW", "centre" : { "x" : 650, "y" : 363 } } } ] }, { "id" : 98166, "reactomeId" : 2024002, "displayName" : "I(1,3,4,5)P4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 642, "y" : 471 }, "minX" : 599, "maxX" : 687, "minY" : 427, "maxY" : 486, "prop" : { "x" : 599, "y" : 456, "width" : 87, "height" : 30 }, "textPosition" : { "x" : 602, "y" : 460 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 681, "y" : 461 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 681, "y" : 461 } } }, "connectors" : [ { "edgeId" : 98164, "type" : "INPUT", "segments" : [ { "from" : { "x" : 641, "y" : 453 }, "to" : { "x" : 641, "y" : 427 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98169, "reactomeId" : 10597885, "displayName" : "minpp1b", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 698, "y" : 385 }, "minX" : 650, "maxX" : 731, "minY" : 368, "maxY" : 401, "prop" : { "x" : 672, "y" : 374, "width" : 53, "height" : 22 }, "textPosition" : { "x" : 675, "y" : 368 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 725, "y" : 374 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 725, "y" : 374 } } }, "connectors" : [ { "edgeId" : 98164, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 669, "y" : 392 }, "to" : { "x" : 657, "y" : 395 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 654, "y" : 397 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 654, "y" : 397 } } } ] }, { "id" : 98168, "reactomeId" : 113551, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 600, "y" : 358 }, "minX" : 586, "maxX" : 641, "minY" : 342, "maxY" : 373, "prop" : { "x" : 586, "y" : 343, "width" : 28, "height" : 30 }, "textPosition" : { "x" : 590, "y" : 347 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 609, "y" : 348 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 609, "y" : 348 } } }, "connectors" : [ { "edgeId" : 98164, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 617, "y" : 362 }, "to" : { "x" : 641, "y" : 372 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 625, "y" : 361 }, "b" : { "x" : 617, "y" : 362 }, "c" : { "x" : 622, "y" : 368 }, "type" : "ARROW", "centre" : { "x" : 622, "y" : 368 } } } ] }, { "id" : 98171, "reactomeId" : 1629753, "displayName" : "I4P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 171, "y" : 208 }, "minX" : 148, "maxX" : 225, "minY" : 176, "maxY" : 243, "prop" : { "x" : 152, "y" : 193, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 158, "y" : 197 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 186, "y" : 198 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 186, "y" : 198 } } }, "connectors" : [ { "edgeId" : 98183, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 194, "y" : 196 }, "to" : { "x" : 225, "y" : 176 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 198, "y" : 189 }, "b" : { "x" : 194, "y" : 196 }, "c" : { "x" : 202, "y" : 196 }, "type" : "ARROW", "centre" : { "x" : 202, "y" : 196 } } }, { "edgeId" : 98170, "type" : "INPUT", "segments" : [ { "from" : { "x" : 161, "y" : 226 }, "to" : { "x" : 148, "y" : 243 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98173, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 67, "y" : 367 }, "minX" : 52, "maxX" : 121, "minY" : 336, "maxY" : 394, "prop" : { "x" : 52, "y" : 352, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 57, "y" : 356 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 77, "y" : 357 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 77, "y" : 357 } } }, "connectors" : [ { "edgeId" : 98191, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 85, "y" : 374 }, "to" : { "x" : 120, "y" : 394 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 93, "y" : 374 }, "b" : { "x" : 85, "y" : 374 }, "c" : { "x" : 89, "y" : 381 }, "type" : "ARROW", "centre" : { "x" : 89, "y" : 381 } } }, { "edgeId" : 98170, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 85, "y" : 358 }, "to" : { "x" : 121, "y" : 336 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 89, "y" : 351 }, "b" : { "x" : 85, "y" : 358 }, "c" : { "x" : 93, "y" : 358 }, "type" : "ARROW", "centre" : { "x" : 93, "y" : 358 } } } ] }, { "id" : 98172, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 192, "y" : 255 }, "minX" : 148, "maxX" : 215, "minY" : 239, "maxY" : 270, "prop" : { "x" : 171, "y" : 240, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 175, "y" : 244 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 209, "y" : 245 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 209, "y" : 245 } } }, "connectors" : [ { "edgeId" : 98170, "type" : "INPUT", "segments" : [ { "from" : { "x" : 168, "y" : 249 }, "to" : { "x" : 148, "y" : 243 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98175, "reactomeId" : 10597847, "displayName" : "IMPA1/2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 265, "y" : 291 }, "minX" : 129, "maxX" : 294, "minY" : 281, "maxY" : 405, "prop" : { "x" : 236, "y" : 281, "width" : 58, "height" : 21 }, "textPosition" : { "x" : 236, "y" : 281 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 98187, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 265, "y" : 308 }, "to" : { "x" : 266, "y" : 397 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 266, "y" : 401 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 266, "y" : 401 } } }, { "edgeId" : 98170, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 230, "y" : 291 }, "to" : { "x" : 137, "y" : 293 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 133, "y" : 293 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 133, "y" : 293 } } } ] }, { "id" : 98174, "reactomeId" : 426910, "displayName" : "Ins", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 170, "y" : 367 }, "minX" : 120, "maxX" : 219, "minY" : 336, "maxY" : 703, "prop" : { "x" : 151, "y" : 352, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 157, "y" : 356 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 185, "y" : 357 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 185, "y" : 357 } } }, "connectors" : [ { "edgeId" : 98187, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 186, "y" : 385 }, "to" : { "x" : 219, "y" : 412 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 194, "y" : 386 }, "b" : { "x" : 186, "y" : 385 }, "c" : { "x" : 189, "y" : 392 }, "type" : "ARROW", "centre" : { "x" : 189, "y" : 392 } } }, { "edgeId" : 98191, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 148, "y" : 377 }, "to" : { "x" : 120, "y" : 394 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 144, "y" : 384 }, "b" : { "x" : 148, "y" : 377 }, "c" : { "x" : 140, "y" : 377 }, "type" : "ARROW", "centre" : { "x" : 140, "y" : 377 } } }, { "edgeId" : 98381, "type" : "INPUT", "segments" : [ { "from" : { "x" : 168, "y" : 385 }, "to" : { "x" : 129, "y" : 703 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98170, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 148, "y" : 354 }, "to" : { "x" : 121, "y" : 336 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 140, "y" : 353 }, "b" : { "x" : 148, "y" : 354 }, "c" : { "x" : 144, "y" : 347 }, "type" : "ARROW", "centre" : { "x" : 144, "y" : 347 } } } ] }, { "id" : 98177, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 603, "y" : 169 }, "minX" : 582, "maxX" : 626, "minY" : 153, "maxY" : 216, "prop" : { "x" : 582, "y" : 154, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 586, "y" : 158 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 620, "y" : 159 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 620, "y" : 159 } } }, "connectors" : [ { "edgeId" : 98176, "type" : "INPUT", "segments" : [ { "from" : { "x" : 597, "y" : 187 }, "to" : { "x" : 586, "y" : 216 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98181, "type" : "INPUT", "segments" : [ { "from" : { "x" : 603, "y" : 187 }, "to" : { "x" : 603, "y" : 203 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98179, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 396, "y" : 220 }, "minX" : 381, "maxX" : 460, "minY" : 164, "maxY" : 235, "prop" : { "x" : 381, "y" : 205, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 386, "y" : 209 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 406, "y" : 210 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 406, "y" : 210 } } }, "connectors" : [ { "edgeId" : 98176, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 414, "y" : 212 }, "to" : { "x" : 460, "y" : 190 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 419, "y" : 205 }, "b" : { "x" : 414, "y" : 212 }, "c" : { "x" : 422, "y" : 213 }, "type" : "ARROW", "centre" : { "x" : 422, "y" : 213 } } }, { "edgeId" : 98181, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 411, "y" : 202 }, "to" : { "x" : 452, "y" : 164 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 413, "y" : 194 }, "b" : { "x" : 411, "y" : 202 }, "c" : { "x" : 419, "y" : 200 }, "type" : "ARROW", "centre" : { "x" : 419, "y" : 200 } } } ] }, { "id" : 98178, "reactomeId" : 1629739, "displayName" : "I(1,4)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 355, "y" : 137 }, "minX" : 292, "maxX" : 460, "minY" : 121, "maxY" : 190, "prop" : { "x" : 324, "y" : 122, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 327, "y" : 126 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 382, "y" : 127 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 382, "y" : 127 } } }, "connectors" : [ { "edgeId" : 98176, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 384, "y" : 155 }, "to" : { "x" : 460, "y" : 190 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 392, "y" : 154 }, "b" : { "x" : 384, "y" : 155 }, "c" : { "x" : 389, "y" : 162 }, "type" : "ARROW", "centre" : { "x" : 389, "y" : 162 } } }, { "edgeId" : 98181, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 390, "y" : 145 }, "to" : { "x" : 452, "y" : 164 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 398, "y" : 143 }, "b" : { "x" : 390, "y" : 145 }, "c" : { "x" : 395, "y" : 151 }, "type" : "ARROW", "centre" : { "x" : 395, "y" : 151 } } }, { "edgeId" : 98183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 331, "y" : 155 }, "to" : { "x" : 292, "y" : 177 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98180, "reactomeId" : 10597398, "displayName" : "ocrl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 508, "y" : 223 }, "minX" : 477, "maxX" : 546, "minY" : 199, "maxY" : 235, "prop" : { "x" : 477, "y" : 211, "width" : 63, "height" : 24 }, "textPosition" : { "x" : 493, "y" : 212 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 540, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 540, "y" : 211 } } }, "connectors" : [ { "edgeId" : 98176, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 506, "y" : 205 }, "to" : { "x" : 506, "y" : 207 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 506, "y" : 203 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 506, "y" : 203 } } } ] }, { "id" : 98182, "reactomeId" : 10598060, "displayName" : "inpp5l", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 406, "y" : 17 }, "minX" : 374, "maxX" : 476, "minY" : 0, "maxY" : 158, "prop" : { "x" : 374, "y" : 6, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 383, "y" : 6 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 438, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 438, "y" : 6 } } }, "connectors" : [ { "edgeId" : 98181, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 411, "y" : 34 }, "to" : { "x" : 470, "y" : 151 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 472, "y" : 154 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 472, "y" : 154 } } } ] }, { "id" : 98185, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 187, "y" : 146 }, "minX" : 172, "maxX" : 225, "minY" : 130, "maxY" : 176, "prop" : { "x" : 172, "y" : 131, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 177, "y" : 135 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 197, "y" : 136 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 197, "y" : 136 } } }, "connectors" : [ { "edgeId" : 98183, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 205, "y" : 157 }, "to" : { "x" : 225, "y" : 176 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 213, "y" : 159 }, "b" : { "x" : 205, "y" : 157 }, "c" : { "x" : 207, "y" : 165 }, "type" : "ARROW", "centre" : { "x" : 207, "y" : 165 } } } ] }, { "id" : 98184, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 334, "y" : 211 }, "minX" : 292, "maxX" : 357, "minY" : 177, "maxY" : 226, "prop" : { "x" : 313, "y" : 196, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 317, "y" : 200 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 351, "y" : 201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 351, "y" : 201 } } }, "connectors" : [ { "edgeId" : 98183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 315, "y" : 193 }, "to" : { "x" : 292, "y" : 177 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98186, "reactomeId" : 10598007, "displayName" : "INPP1:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 256, "y" : 126 }, "minX" : 215, "maxX" : 303, "minY" : 109, "maxY" : 169, "prop" : { "x" : 215, "y" : 115, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 232, "y" : 102 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 297, "y" : 115 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 297, "y" : 115 } } }, "connectors" : [ { "edgeId" : 98183, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 256, "y" : 140 }, "to" : { "x" : 257, "y" : 161 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 257, "y" : 165 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 257, "y" : 165 } } } ] }, { "id" : 98189, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 371, "y" : 426 }, "minX" : 319, "maxX" : 394, "minY" : 410, "maxY" : 465, "prop" : { "x" : 350, "y" : 411, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 354, "y" : 415 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 388, "y" : 416 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 388, "y" : 416 } } }, "connectors" : [ { "edgeId" : 98187, "type" : "INPUT", "segments" : [ { "from" : { "x" : 347, "y" : 421 }, "to" : { "x" : 319, "y" : 414 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98195, "type" : "INPUT", "segments" : [ { "from" : { "x" : 352, "y" : 444 }, "to" : { "x" : 324, "y" : 465 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98188, "reactomeId" : 870330, "displayName" : "I1P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 375, "y" : 348 }, "minX" : 319, "maxX" : 395, "minY" : 332, "maxY" : 414, "prop" : { "x" : 357, "y" : 333, "width" : 37, "height" : 30 }, "textPosition" : { "x" : 362, "y" : 337 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 389, "y" : 338 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 389, "y" : 338 } } }, "connectors" : [ { "edgeId" : 98187, "type" : "INPUT", "segments" : [ { "from" : { "x" : 362, "y" : 366 }, "to" : { "x" : 319, "y" : 414 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98190, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 191, "y" : 435 }, "minX" : 176, "maxX" : 219, "minY" : 412, "maxY" : 465, "prop" : { "x" : 176, "y" : 420, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 181, "y" : 424 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 201, "y" : 425 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 201, "y" : 425 } } }, "connectors" : [ { "edgeId" : 98187, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 209, "y" : 422 }, "to" : { "x" : 219, "y" : 412 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 211, "y" : 414 }, "b" : { "x" : 209, "y" : 422 }, "c" : { "x" : 217, "y" : 420 }, "type" : "ARROW", "centre" : { "x" : 217, "y" : 420 } } }, { "edgeId" : 98195, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 200, "y" : 453 }, "to" : { "x" : 209, "y" : 465 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 207, "y" : 456 }, "b" : { "x" : 200, "y" : 453 }, "c" : { "x" : 201, "y" : 461 }, "type" : "ARROW", "centre" : { "x" : 201, "y" : 461 } } } ] }, { "id" : 98193, "reactomeId" : 1629731, "displayName" : "I3P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 174, "y" : 528 }, "minX" : 119, "maxX" : 209, "minY" : 465, "maxY" : 543, "prop" : { "x" : 157, "y" : 513, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 161, "y" : 517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 187, "y" : 518 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 187, "y" : 518 } } }, "connectors" : [ { "edgeId" : 98191, "type" : "INPUT", "segments" : [ { "from" : { "x" : 154, "y" : 527 }, "to" : { "x" : 119, "y" : 527 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98195, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 182, "y" : 510 }, "to" : { "x" : 209, "y" : 465 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 182, "y" : 502 }, "b" : { "x" : 182, "y" : 510 }, "c" : { "x" : 189, "y" : 506 }, "type" : "ARROW", "centre" : { "x" : 189, "y" : 506 } } } ] }, { "id" : 98192, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 71, "y" : 528 }, "minX" : 50, "maxX" : 119, "minY" : 512, "maxY" : 543, "prop" : { "x" : 50, "y" : 513, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 54, "y" : 517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 88, "y" : 518 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 88, "y" : 518 } } }, "connectors" : [ { "edgeId" : 98191, "type" : "INPUT", "segments" : [ { "from" : { "x" : 96, "y" : 527 }, "to" : { "x" : 119, "y" : 527 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98194, "reactomeId" : 10597847, "displayName" : "IMPA1/2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 58, "y" : 460 }, "minX" : 26, "maxX" : 112, "minY" : 450, "maxY" : 470, "prop" : { "x" : 26, "y" : 450, "width" : 64, "height" : 20 }, "textPosition" : { "x" : 29, "y" : 450 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 98191, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 96, "y" : 462 }, "to" : { "x" : 104, "y" : 463 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 108, "y" : 463 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 108, "y" : 463 } } } ] }, { "id" : 98197, "reactomeId" : 10597551, "displayName" : "inpp4aa", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 275, "y" : 518 }, "minX" : 243, "maxX" : 313, "minY" : 472, "maxY" : 529, "prop" : { "x" : 243, "y" : 507, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 245, "y" : 507 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 307, "y" : 507 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 307, "y" : 507 } } }, "connectors" : [ { "edgeId" : 98195, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 274, "y" : 501 }, "to" : { "x" : 274, "y" : 480 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 274, "y" : 476 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 274, "y" : 476 } } } ] }, { "id" : 98196, "reactomeId" : 1629746, "displayName" : "I(3,4)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 365, "y" : 530 }, "minX" : 324, "maxX" : 405, "minY" : 465, "maxY" : 581, "prop" : { "x" : 334, "y" : 515, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 337, "y" : 519 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 392, "y" : 520 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 392, "y" : 520 } } }, "connectors" : [ { "edgeId" : 98195, "type" : "INPUT", "segments" : [ { "from" : { "x" : 355, "y" : 512 }, "to" : { "x" : 324, "y" : 465 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98198, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 376, "y" : 548 }, "to" : { "x" : 405, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 384, "y" : 551 }, "b" : { "x" : 376, "y" : 548 }, "c" : { "x" : 378, "y" : 556 }, "type" : "ARROW", "centre" : { "x" : 378, "y" : 556 } } } ] }, { "id" : 98199, "reactomeId" : 994123, "displayName" : "I(1,3,4)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 685, "y" : 631 }, "minX" : 594, "maxX" : 799, "minY" : 572, "maxY" : 685, "prop" : { "x" : 648, "y" : 616, "width" : 75, "height" : 30 }, "textPosition" : { "x" : 651, "y" : 620 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 718, "y" : 621 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 718, "y" : 621 } } }, "connectors" : [ { "edgeId" : 98198, "type" : "INPUT", "segments" : [ { "from" : { "x" : 657, "y" : 613 }, "to" : { "x" : 594, "y" : 582 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98203, "type" : "INPUT", "segments" : [ { "from" : { "x" : 670, "y" : 649 }, "to" : { "x" : 631, "y" : 685 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98213, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 698, "y" : 613 }, "to" : { "x" : 738, "y" : 572 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 700, "y" : 605 }, "b" : { "x" : 698, "y" : 613 }, "c" : { "x" : 706, "y" : 611 }, "type" : "ARROW", "centre" : { "x" : 706, "y" : 611 } } }, { "edgeId" : 98217, "type" : "INPUT", "segments" : [ { "from" : { "x" : 726, "y" : 622 }, "to" : { "x" : 799, "y" : 605 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98222, "type" : "INPUT", "segments" : [ { "from" : { "x" : 715, "y" : 649 }, "to" : { "x" : 783, "y" : 680 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98227, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 697, "y" : 649 }, "to" : { "x" : 723, "y" : 676 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 705, "y" : 651 }, "b" : { "x" : 697, "y" : 649 }, "c" : { "x" : 699, "y" : 657 }, "type" : "ARROW", "centre" : { "x" : 699, "y" : 657 } } } ] }, { "id" : 98201, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 372, "y" : 623 }, "minX" : 357, "maxX" : 405, "minY" : 581, "maxY" : 638, "prop" : { "x" : 357, "y" : 608, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 362, "y" : 612 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 382, "y" : 613 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 382, "y" : 613 } } }, "connectors" : [ { "edgeId" : 98198, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 383, "y" : 605 }, "to" : { "x" : 405, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 385, "y" : 597 }, "b" : { "x" : 383, "y" : 605 }, "c" : { "x" : 391, "y" : 603 }, "type" : "ARROW", "centre" : { "x" : 391, "y" : 603 } } } ] }, { "id" : 98200, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 629, "y" : 538 }, "minX" : 594, "maxX" : 652, "minY" : 522, "maxY" : 582, "prop" : { "x" : 608, "y" : 523, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 612, "y" : 527 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 646, "y" : 528 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 646, "y" : 528 } } }, "connectors" : [ { "edgeId" : 98198, "type" : "INPUT", "segments" : [ { "from" : { "x" : 617, "y" : 556 }, "to" : { "x" : 594, "y" : 582 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98202, "reactomeId" : 10598007, "displayName" : "INPP1:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 533, "y" : 538 }, "minX" : 493, "maxX" : 580, "minY" : 521, "maxY" : 574, "prop" : { "x" : 493, "y" : 527, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 509, "y" : 514 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 574, "y" : 527 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 574, "y" : 527 } } }, "connectors" : [ { "edgeId" : 98198, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 533, "y" : 552 }, "to" : { "x" : 534, "y" : 566 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 535, "y" : 570 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 535, "y" : 570 } } } ] }, { "id" : 98205, "reactomeId" : 1629769, "displayName" : "I(1,3)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 573, "y" : 823 }, "minX" : 542, "maxX" : 630, "minY" : 788, "maxY" : 838, "prop" : { "x" : 542, "y" : 808, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 545, "y" : 812 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 600, "y" : 813 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 600, "y" : 813 } } }, "connectors" : [ { "edgeId" : 98203, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 597, "y" : 805 }, "to" : { "x" : 630, "y" : 788 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 601, "y" : 798 }, "b" : { "x" : 597, "y" : 805 }, "c" : { "x" : 605, "y" : 805 }, "type" : "ARROW", "centre" : { "x" : 605, "y" : 805 } } } ] }, { "id" : 98204, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 592, "y" : 634 }, "minX" : 571, "maxX" : 631, "minY" : 618, "maxY" : 685, "prop" : { "x" : 571, "y" : 619, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 575, "y" : 623 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 609, "y" : 624 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 609, "y" : 624 } } }, "connectors" : [ { "edgeId" : 98203, "type" : "INPUT", "segments" : [ { "from" : { "x" : 603, "y" : 652 }, "to" : { "x" : 631, "y" : 685 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98207, "reactomeId" : 10597551, "displayName" : "inpp4aa", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 561, "y" : 731 }, "minX" : 529, "maxX" : 622, "minY" : 714, "maxY" : 742, "prop" : { "x" : 529, "y" : 720, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 531, "y" : 720 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 593, "y" : 720 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 593, "y" : 720 } } }, "connectors" : [ { "edgeId" : 98203, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 599, "y" : 731 }, "to" : { "x" : 614, "y" : 731 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 618, "y" : 731 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 618, "y" : 731 } } } ] }, { "id" : 98206, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 656, "y" : 832 }, "minX" : 630, "maxX" : 672, "minY" : 788, "maxY" : 847, "prop" : { "x" : 641, "y" : 817, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 646, "y" : 821 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 666, "y" : 822 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 666, "y" : 822 } } }, "connectors" : [ { "edgeId" : 98203, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 647, "y" : 814 }, "to" : { "x" : 630, "y" : 788 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 640, "y" : 810 }, "b" : { "x" : 647, "y" : 814 }, "c" : { "x" : 647, "y" : 806 }, "type" : "ARROW", "centre" : { "x" : 647, "y" : 806 } } } ] }, { "id" : 98209, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 929, "y" : 405 }, "minX" : 872, "maxX" : 952, "minY" : 389, "maxY" : 420, "prop" : { "x" : 908, "y" : 390, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 912, "y" : 394 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 946, "y" : 395 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 946, "y" : 395 } } }, "connectors" : [ { "edgeId" : 98208, "type" : "INPUT", "segments" : [ { "from" : { "x" : 905, "y" : 400 }, "to" : { "x" : 872, "y" : 392 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98211, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 856, "y" : 221 }, "minX" : 801, "maxX" : 872, "minY" : 205, "maxY" : 236, "prop" : { "x" : 841, "y" : 206, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 846, "y" : 210 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 866, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 866, "y" : 211 } } }, "connectors" : [ { "edgeId" : 98208, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 838, "y" : 221 }, "to" : { "x" : 801, "y" : 221 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 831, "y" : 225 }, "b" : { "x" : 838, "y" : 221 }, "c" : { "x" : 831, "y" : 217 }, "type" : "ARROW", "centre" : { "x" : 831, "y" : 217 } } } ] }, { "id" : 98210, "reactomeId" : 994170, "displayName" : "I(1,3,4,5)P4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 843, "y" : 474 }, "minX" : 800, "maxX" : 907, "minY" : 392, "maxY" : 514, "prop" : { "x" : 800, "y" : 459, "width" : 87, "height" : 30 }, "textPosition" : { "x" : 803, "y" : 463 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 882, "y" : 464 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 882, "y" : 464 } } }, "connectors" : [ { "edgeId" : 98208, "type" : "INPUT", "segments" : [ { "from" : { "x" : 848, "y" : 456 }, "to" : { "x" : 872, "y" : 392 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98213, "type" : "INPUT", "segments" : [ { "from" : { "x" : 826, "y" : 492 }, "to" : { "x" : 800, "y" : 514 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98217, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 873, "y" : 492 }, "to" : { "x" : 907, "y" : 506 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 881, "y" : 491 }, "b" : { "x" : 873, "y" : 492 }, "c" : { "x" : 878, "y" : 498 }, "type" : "ARROW", "centre" : { "x" : 878, "y" : 498 } } }, { "edgeId" : 98242, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98212, "reactomeId" : 10597992, "displayName" : "PTEN:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 937, "y" : 267 }, "minX" : 868, "maxX" : 983, "minY" : 250, "maxY" : 292, "prop" : { "x" : 898, "y" : 256, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 915, "y" : 243 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 977, "y" : 256 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 977, "y" : 256 } } }, "connectors" : [ { "edgeId" : 98208, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 901, "y" : 281 }, "to" : { "x" : 876, "y" : 287 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 872, "y" : 288 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 872, "y" : 288 } } } ] }, { "id" : 98215, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 666, "y" : 588 }, "minX" : 651, "maxX" : 738, "minY" : 572, "maxY" : 603, "prop" : { "x" : 651, "y" : 573, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 656, "y" : 577 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 676, "y" : 578 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 676, "y" : 578 } } }, "connectors" : [ { "edgeId" : 98213, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 684, "y" : 584 }, "to" : { "x" : 738, "y" : 572 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 690, "y" : 579 }, "b" : { "x" : 684, "y" : 584 }, "c" : { "x" : 692, "y" : 586 }, "type" : "ARROW", "centre" : { "x" : 692, "y" : 586 } } } ] }, { "id" : 98214, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 857, "y" : 518 }, "minX" : 800, "maxX" : 880, "minY" : 502, "maxY" : 533, "prop" : { "x" : 836, "y" : 503, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 840, "y" : 507 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 874, "y" : 508 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 874, "y" : 508 } } }, "connectors" : [ { "edgeId" : 98213, "type" : "INPUT", "segments" : [ { "from" : { "x" : 833, "y" : 516 }, "to" : { "x" : 800, "y" : 514 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98216, "reactomeId" : 10598029, "displayName" : "INPP5(3)/ITPK1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 714, "y" : 532 }, "minX" : 685, "maxX" : 763, "minY" : 510, "maxY" : 555, "prop" : { "x" : 685, "y" : 510, "width" : 59, "height" : 45 }, "textPosition" : { "x" : 692, "y" : 508 }, "connectors" : [ { "edgeId" : 98213, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 750, "y" : 539 }, "to" : { "x" : 755, "y" : 541 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 759, "y" : 542 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 759, "y" : 542 } } } ] }, { "id" : 98219, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 956, "y" : 542 }, "minX" : 907, "maxX" : 977, "minY" : 506, "maxY" : 558, "prop" : { "x" : 937, "y" : 527, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 940, "y" : 532 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 971, "y" : 532 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 971, "y" : 532 } } }, "connectors" : [ { "edgeId" : 98217, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 934, "y" : 527 }, "to" : { "x" : 907, "y" : 506 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 926, "y" : 526 }, "b" : { "x" : 934, "y" : 527 }, "c" : { "x" : 931, "y" : 520 }, "type" : "ARROW", "centre" : { "x" : 931, "y" : 520 } } } ] }, { "id" : 98218, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 843, "y" : 648 }, "minX" : 783, "maxX" : 864, "minY" : 605, "maxY" : 680, "prop" : { "x" : 823, "y" : 633, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 827, "y" : 637 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 858, "y" : 638 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 858, "y" : 638 } } }, "connectors" : [ { "edgeId" : 98217, "type" : "INPUT", "segments" : [ { "from" : { "x" : 827, "y" : 630 }, "to" : { "x" : 799, "y" : 605 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98222, "type" : "INPUT", "segments" : [ { "from" : { "x" : 820, "y" : 658 }, "to" : { "x" : 783, "y" : 680 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98221, "reactomeId" : 10597872, "displayName" : "ITPK1:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 928, "y" : 585 }, "minX" : 865, "maxX" : 975, "minY" : 557, "maxY" : 596, "prop" : { "x" : 887, "y" : 574, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 887, "y" : 575 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 969, "y" : 574 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 969, "y" : 574 } } }, "connectors" : [ { "edgeId" : 98217, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 900, "y" : 571 }, "to" : { "x" : 873, "y" : 562 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 869, "y" : 561 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 869, "y" : 561 } } } ] }, { "id" : 98220, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 959, "y" : 485 }, "minX" : 907, "maxX" : 979, "minY" : 471, "maxY" : 506, "prop" : { "x" : 940, "y" : 472, "width" : 38, "height" : 26 }, "textPosition" : { "x" : 945, "y" : 474 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 973, "y" : 477 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 973, "y" : 477 } } }, "connectors" : [ { "edgeId" : 98217, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 937, "y" : 492 }, "to" : { "x" : 907, "y" : 506 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 932, "y" : 499 }, "b" : { "x" : 937, "y" : 492 }, "c" : { "x" : 929, "y" : 491 }, "type" : "ARROW", "centre" : { "x" : 929, "y" : 491 } } } ], "trivial" : true }, { "id" : 98223, "reactomeId" : 994146, "displayName" : "I(1,3,4,6)P4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 845, "y" : 817 }, "minX" : 723, "maxX" : 890, "minY" : 766, "maxY" : 869, "prop" : { "x" : 802, "y" : 802, "width" : 87, "height" : 30 }, "textPosition" : { "x" : 805, "y" : 806 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 884, "y" : 807 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 884, "y" : 807 } } }, "connectors" : [ { "edgeId" : 98222, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 832, "y" : 799 }, "to" : { "x" : 801, "y" : 766 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 824, "y" : 797 }, "b" : { "x" : 832, "y" : 799 }, "c" : { "x" : 830, "y" : 791 }, "type" : "ARROW", "centre" : { "x" : 830, "y" : 791 } } }, { "edgeId" : 98227, "type" : "INPUT", "segments" : [ { "from" : { "x" : 802, "y" : 799 }, "to" : { "x" : 723, "y" : 774 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 829, "y" : 835 }, "to" : { "x" : 795, "y" : 865 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98235, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 853, "y" : 835 }, "to" : { "x" : 875, "y" : 869 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 860, "y" : 839 }, "b" : { "x" : 853, "y" : 835 }, "c" : { "x" : 853, "y" : 843 }, "type" : "ARROW", "centre" : { "x" : 853, "y" : 843 } } }, { "edgeId" : 98244, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98225, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 858, "y" : 744 }, "minX" : 801, "maxX" : 880, "minY" : 728, "maxY" : 766, "prop" : { "x" : 838, "y" : 729, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 842, "y" : 733 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 874, "y" : 734 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 874, "y" : 734 } } }, "connectors" : [ { "edgeId" : 98222, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 835, "y" : 751 }, "to" : { "x" : 801, "y" : 766 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 830, "y" : 757 }, "b" : { "x" : 835, "y" : 751 }, "c" : { "x" : 827, "y" : 750 }, "type" : "ARROW", "centre" : { "x" : 827, "y" : 750 } } } ] }, { "id" : 98224, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 870, "y" : 782 }, "minX" : 801, "maxX" : 891, "minY" : 766, "maxY" : 794, "prop" : { "x" : 851, "y" : 770, "width" : 39, "height" : 24 }, "textPosition" : { "x" : 857, "y" : 771 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 885, "y" : 775 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 885, "y" : 775 } } }, "connectors" : [ { "edgeId" : 98222, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 848, "y" : 777 }, "to" : { "x" : 801, "y" : 766 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 840, "y" : 779 }, "b" : { "x" : 848, "y" : 777 }, "c" : { "x" : 842, "y" : 772 }, "type" : "ARROW", "centre" : { "x" : 842, "y" : 772 } } } ], "trivial" : true }, { "id" : 98226, "reactomeId" : 10597872, "displayName" : "ITPK1:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 834, "y" : 701 }, "minX" : 730, "maxX" : 881, "minY" : 684, "maxY" : 732, "prop" : { "x" : 793, "y" : 690, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 793, "y" : 691 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 875, "y" : 690 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 875, "y" : 690 } } }, "connectors" : [ { "edgeId" : 98222, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 816, "y" : 715 }, "to" : { "x" : 796, "y" : 726 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 792, "y" : 728 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 792, "y" : 728 } } }, { "edgeId" : 98227, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 790, "y" : 711 }, "to" : { "x" : 737, "y" : 726 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 734, "y" : 727 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 734, "y" : 727 } } } ] }, { "id" : 98229, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 668, "y" : 691 }, "minX" : 653, "maxX" : 723, "minY" : 675, "maxY" : 706, "prop" : { "x" : 653, "y" : 676, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 658, "y" : 680 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 678, "y" : 681 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 678, "y" : 681 } } }, "connectors" : [ { "edgeId" : 98227, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 686, "y" : 686 }, "to" : { "x" : 723, "y" : 676 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 692, "y" : 680 }, "b" : { "x" : 686, "y" : 686 }, "c" : { "x" : 694, "y" : 688 }, "type" : "ARROW", "centre" : { "x" : 694, "y" : 688 } } } ] }, { "id" : 98228, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 678, "y" : 791 }, "minX" : 657, "maxX" : 723, "minY" : 774, "maxY" : 806, "prop" : { "x" : 657, "y" : 776, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 661, "y" : 780 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 695, "y" : 781 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 695, "y" : 781 } } }, "connectors" : [ { "edgeId" : 98227, "type" : "INPUT", "segments" : [ { "from" : { "x" : 703, "y" : 782 }, "to" : { "x" : 723, "y" : 774 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98231, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 749, "y" : 849 }, "minX" : 728, "maxX" : 795, "minY" : 833, "maxY" : 865, "prop" : { "x" : 728, "y" : 834, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 732, "y" : 838 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 766, "y" : 839 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 766, "y" : 839 } } }, "connectors" : [ { "edgeId" : 98230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 774, "y" : 856 }, "to" : { "x" : 795, "y" : 865 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98233, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 755, "y" : 997 }, "minX" : 740, "maxX" : 796, "minY" : 951, "maxY" : 1012, "prop" : { "x" : 740, "y" : 982, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 745, "y" : 986 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 765, "y" : 987 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 765, "y" : 987 } } }, "connectors" : [ { "edgeId" : 98230, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 768, "y" : 979 }, "to" : { "x" : 796, "y" : 951 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 770, "y" : 971 }, "b" : { "x" : 768, "y" : 979 }, "c" : { "x" : 776, "y" : 977 }, "type" : "ARROW", "centre" : { "x" : 776, "y" : 977 } } } ] }, { "id" : 98232, "reactomeId" : 1629741, "displayName" : "I(3,4,6)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 840, "y" : 999 }, "minX" : 796, "maxX" : 879, "minY" : 951, "maxY" : 1014, "prop" : { "x" : 803, "y" : 984, "width" : 75, "height" : 30 }, "textPosition" : { "x" : 806, "y" : 988 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 873, "y" : 989 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 873, "y" : 989 } } }, "connectors" : [ { "edgeId" : 98230, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 826, "y" : 981 }, "to" : { "x" : 796, "y" : 951 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 818, "y" : 979 }, "b" : { "x" : 826, "y" : 981 }, "c" : { "x" : 824, "y" : 973 }, "type" : "ARROW", "centre" : { "x" : 824, "y" : 973 } } }, { "edgeId" : 98235, "type" : "INPUT", "segments" : [ { "from" : { "x" : 851, "y" : 981 }, "to" : { "x" : 878, "y" : 951 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98234, "reactomeId" : 10597872, "displayName" : "ITPK1:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 710, "y" : 910 }, "minX" : 669, "maxX" : 867, "minY" : 893, "maxY" : 923, "prop" : { "x" : 669, "y" : 899, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 669, "y" : 900 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 751, "y" : 899 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 751, "y" : 899 } } }, "connectors" : [ { "edgeId" : 98230, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 754, "y" : 915 }, "to" : { "x" : 779, "y" : 919 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 783, "y" : 919 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 783, "y" : 919 } } }, { "edgeId" : 98235, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 754, "y" : 908 }, "to" : { "x" : 859, "y" : 904 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 863, "y" : 903 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 863, "y" : 903 } } } ] }, { "id" : 98237, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 976, "y" : 862 }, "minX" : 875, "maxX" : 997, "minY" : 847, "maxY" : 876, "prop" : { "x" : 957, "y" : 848, "width" : 39, "height" : 28 }, "textPosition" : { "x" : 963, "y" : 851 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 991, "y" : 853 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 991, "y" : 853 } } }, "connectors" : [ { "edgeId" : 98235, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 954, "y" : 863 }, "to" : { "x" : 875, "y" : 869 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 947, "y" : 868 }, "b" : { "x" : 954, "y" : 863 }, "c" : { "x" : 947, "y" : 860 }, "type" : "ARROW", "centre" : { "x" : 947, "y" : 860 } } } ], "trivial" : true }, { "id" : 98236, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 929, "y" : 1002 }, "minX" : 878, "maxX" : 950, "minY" : 951, "maxY" : 1017, "prop" : { "x" : 909, "y" : 987, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 913, "y" : 991 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 944, "y" : 992 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 944, "y" : 992 } } }, "connectors" : [ { "edgeId" : 98235, "type" : "INPUT", "segments" : [ { "from" : { "x" : 914, "y" : 984 }, "to" : { "x" : 878, "y" : 951 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98238, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 931, "y" : 838 }, "minX" : 875, "maxX" : 953, "minY" : 822, "maxY" : 869, "prop" : { "x" : 911, "y" : 823, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 915, "y" : 827 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 947, "y" : 828 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 947, "y" : 828 } } }, "connectors" : [ { "edgeId" : 98235, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 908, "y" : 849 }, "to" : { "x" : 875, "y" : 869 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 904, "y" : 856 }, "b" : { "x" : 908, "y" : 849 }, "c" : { "x" : 900, "y" : 849 }, "type" : "ARROW", "centre" : { "x" : 900, "y" : 849 } } } ] }, { "id" : 98241, "reactomeId" : 10564682, "displayName" : "Nuclear Pore Complex (NPC)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1058, "y" : 307 }, "minX" : 1020, "maxX" : 1102, "minY" : 175, "maxY" : 432, "prop" : { "x" : 1020, "y" : 278, "width" : 76, "height" : 59 }, "textPosition" : { "x" : 1026, "y" : 274 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1096, "y" : 278 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1096, "y" : 278 } } }, "connectors" : [ { "edgeId" : 98239, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1058, "y" : 275 }, "to" : { "x" : 1059, "y" : 183 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1059, "y" : 179 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1059, "y" : 179 } } }, { "edgeId" : 98242, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1058, "y" : 340 }, "to" : { "x" : 1060, "y" : 424 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1060, "y" : 428 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1060, "y" : 428 } } } ] }, { "id" : 98240, "reactomeId" : 2023907, "displayName" : "I(1,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1134, "y" : 170 }, "minX" : 1097, "maxX" : 1173, "minY" : 154, "maxY" : 220, "prop" : { "x" : 1097, "y" : 155, "width" : 75, "height" : 30 }, "textPosition" : { "x" : 1100, "y" : 159 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1167, "y" : 160 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1167, "y" : 160 } } }, "connectors" : [ { "edgeId" : 98239, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98254, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1138, "y" : 188 }, "to" : { "x" : 1150, "y" : 220 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98243, "reactomeId" : 2023891, "displayName" : "I(1,3,4,5)P4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1134, "y" : 440 }, "minX" : 1091, "maxX" : 1192, "minY" : 360, "maxY" : 500, "prop" : { "x" : 1091, "y" : 425, "width" : 87, "height" : 30 }, "textPosition" : { "x" : 1094, "y" : 429 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1173, "y" : 430 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1173, "y" : 430 } } }, "connectors" : [ { "edgeId" : 98242, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98254, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1137, "y" : 422 }, "to" : { "x" : 1150, "y" : 360 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1135, "y" : 414 }, "b" : { "x" : 1137, "y" : 422 }, "c" : { "x" : 1142, "y" : 416 }, "type" : "ARROW", "centre" : { "x" : 1142, "y" : 416 } } }, { "edgeId" : 98259, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1148, "y" : 458 }, "to" : { "x" : 1192, "y" : 500 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98245, "reactomeId" : 2023892, "displayName" : "I(1,3,4,6)P4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1139, "y" : 783 }, "minX" : 1096, "maxX" : 1227, "minY" : 749, "maxY" : 798, "prop" : { "x" : 1096, "y" : 768, "width" : 87, "height" : 30 }, "textPosition" : { "x" : 1099, "y" : 772 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1178, "y" : 773 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1178, "y" : 773 } } }, "connectors" : [ { "edgeId" : 98244, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98263, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1177, "y" : 765 }, "to" : { "x" : 1227, "y" : 749 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98246, "reactomeId" : 10564682, "displayName" : "Nuclear Pore Complex (NPC)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1058, "y" : 716 }, "minX" : 1020, "maxX" : 1102, "minY" : 681, "maxY" : 775, "prop" : { "x" : 1020, "y" : 687, "width" : 76, "height" : 59 }, "textPosition" : { "x" : 1026, "y" : 683 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1096, "y" : 687 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1096, "y" : 687 } } }, "connectors" : [ { "edgeId" : 98244, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1059, "y" : 749 }, "to" : { "x" : 1060, "y" : 767 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1060, "y" : 771 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1060, "y" : 771 } } } ] }, { "id" : 98249, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1181, "y" : 711 }, "minX" : 1161, "maxX" : 1227, "minY" : 651, "maxY" : 749, "prop" : { "x" : 1161, "y" : 696, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1165, "y" : 700 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1196, "y" : 701 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1196, "y" : 701 } } }, "connectors" : [ { "edgeId" : 98247, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1188, "y" : 693 }, "to" : { "x" : 1209, "y" : 651 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98263, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1199, "y" : 729 }, "to" : { "x" : 1227, "y" : 749 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98248, "reactomeId" : 2023935, "displayName" : "I(1,4,5,6)P4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1139, "y" : 620 }, "minX" : 1096, "maxX" : 1209, "minY" : 604, "maxY" : 651, "prop" : { "x" : 1096, "y" : 605, "width" : 87, "height" : 30 }, "textPosition" : { "x" : 1099, "y" : 609 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1178, "y" : 610 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1178, "y" : 610 } } }, "connectors" : [ { "edgeId" : 98247, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1172, "y" : 638 }, "to" : { "x" : 1209, "y" : 651 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98251, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1326, "y" : 697 }, "minX" : 1291, "maxX" : 1351, "minY" : 651, "maxY" : 748, "prop" : { "x" : 1306, "y" : 682, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1310, "y" : 686 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1342, "y" : 687 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1342, "y" : 687 } } }, "connectors" : [ { "edgeId" : 98247, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1314, "y" : 679 }, "to" : { "x" : 1291, "y" : 651 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1307, "y" : 676 }, "b" : { "x" : 1314, "y" : 679 }, "c" : { "x" : 1313, "y" : 671 }, "type" : "ARROW", "centre" : { "x" : 1313, "y" : 671 } } }, { "edgeId" : 98263, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1333, "y" : 715 }, "to" : { "x" : 1351, "y" : 748 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1340, "y" : 719 }, "b" : { "x" : 1333, "y" : 715 }, "c" : { "x" : 1333, "y" : 723 }, "type" : "ARROW", "centre" : { "x" : 1333, "y" : 723 } } } ] }, { "id" : 98250, "reactomeId" : 2023901, "displayName" : "I(1,3,4,5,6)P5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1374, "y" : 618 }, "minX" : 1269, "maxX" : 1463, "minY" : 548, "maxY" : 748, "prop" : { "x" : 1325, "y" : 603, "width" : 99, "height" : 30 }, "textPosition" : { "x" : 1328, "y" : 607 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1419, "y" : 608 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1419, "y" : 608 } } }, "connectors" : [ { "edgeId" : 98338, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98247, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1336, "y" : 636 }, "to" : { "x" : 1291, "y" : 651 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1331, "y" : 642 }, "b" : { "x" : 1336, "y" : 636 }, "c" : { "x" : 1328, "y" : 634 }, "type" : "ARROW", "centre" : { "x" : 1328, "y" : 634 } } }, { "edgeId" : 98259, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1351, "y" : 600 }, "to" : { "x" : 1269, "y" : 548 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1343, "y" : 600 }, "b" : { "x" : 1351, "y" : 600 }, "c" : { "x" : 1347, "y" : 593 }, "type" : "ARROW", "centre" : { "x" : 1347, "y" : 593 } } }, { "edgeId" : 98263, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1371, "y" : 636 }, "to" : { "x" : 1351, "y" : 748 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1374, "y" : 644 }, "b" : { "x" : 1371, "y" : 636 }, "c" : { "x" : 1366, "y" : 642 }, "type" : "ARROW", "centre" : { "x" : 1366, "y" : 642 } } }, { "edgeId" : 98265, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1427, "y" : 629 }, "to" : { "x" : 1463, "y" : 639 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98271, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1390, "y" : 600 }, "to" : { "x" : 1433, "y" : 565 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98253, "reactomeId" : 10597961, "displayName" : "ipmkb", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1258, "y" : 700 }, "minX" : 1240, "maxX" : 1283, "minY" : 660, "maxY" : 741, "prop" : { "x" : 1240, "y" : 689, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 1240, "y" : 683 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1277, "y" : 689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1277, "y" : 689 } } }, "connectors" : [ { "edgeId" : 98247, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1258, "y" : 686 }, "to" : { "x" : 1258, "y" : 668 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1258, "y" : 664 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1258, "y" : 664 } } }, { "edgeId" : 98263, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1258, "y" : 714 }, "to" : { "x" : 1259, "y" : 733 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1259, "y" : 737 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1259, "y" : 737 } } } ] }, { "id" : 98252, "reactomeId" : 9668967, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1286, "y" : 601 }, "minX" : 1271, "maxX" : 1302, "minY" : 587, "maxY" : 651, "prop" : { "x" : 1271, "y" : 588, "width" : 30, "height" : 27 }, "textPosition" : { "x" : 1272, "y" : 591 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1296, "y" : 593 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1296, "y" : 593 } } }, "connectors" : [ { "edgeId" : 98247, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1287, "y" : 618 }, "to" : { "x" : 1291, "y" : 651 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1292, "y" : 624 }, "b" : { "x" : 1287, "y" : 618 }, "c" : { "x" : 1284, "y" : 625 }, "type" : "ARROW", "centre" : { "x" : 1284, "y" : 625 } } } ], "trivial" : true }, { "id" : 98255, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1208, "y" : 170 }, "minX" : 1150, "maxX" : 1229, "minY" : 154, "maxY" : 220, "prop" : { "x" : 1188, "y" : 155, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1192, "y" : 159 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1223, "y" : 160 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1223, "y" : 160 } } }, "connectors" : [ { "edgeId" : 98254, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1190, "y" : 188 }, "to" : { "x" : 1150, "y" : 220 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98257, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1208, "y" : 439 }, "minX" : 1150, "maxX" : 1230, "minY" : 360, "maxY" : 454, "prop" : { "x" : 1188, "y" : 424, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1192, "y" : 428 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1224, "y" : 429 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1224, "y" : 429 } } }, "connectors" : [ { "edgeId" : 98254, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1196, "y" : 421 }, "to" : { "x" : 1150, "y" : 360 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1189, "y" : 418 }, "b" : { "x" : 1196, "y" : 421 }, "c" : { "x" : 1195, "y" : 413 }, "type" : "ARROW", "centre" : { "x" : 1195, "y" : 413 } } } ] }, { "id" : 98256, "reactomeId" : 9668967, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1103, "y" : 388 }, "minX" : 1088, "maxX" : 1150, "minY" : 360, "maxY" : 402, "prop" : { "x" : 1088, "y" : 375, "width" : 30, "height" : 27 }, "textPosition" : { "x" : 1089, "y" : 378 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1113, "y" : 380 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1113, "y" : 380 } } }, "connectors" : [ { "edgeId" : 98254, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1121, "y" : 379 }, "to" : { "x" : 1150, "y" : 360 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1125, "y" : 372 }, "b" : { "x" : 1121, "y" : 379 }, "c" : { "x" : 1129, "y" : 379 }, "type" : "ARROW", "centre" : { "x" : 1129, "y" : 379 } } } ], "trivial" : true }, { "id" : 98258, "reactomeId" : 10597961, "displayName" : "ipmkb", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1215, "y" : 298 }, "minX" : 1158, "maxX" : 1240, "minY" : 281, "maxY" : 309, "prop" : { "x" : 1197, "y" : 287, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 1197, "y" : 281 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1234, "y" : 287 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1234, "y" : 287 } } }, "connectors" : [ { "edgeId" : 98254, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1194, "y" : 298 }, "to" : { "x" : 1166, "y" : 299 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1162, "y" : 299 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1162, "y" : 299 } } } ] }, { "id" : 98261, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1205, "y" : 568 }, "minX" : 1185, "maxX" : 1269, "minY" : 548, "maxY" : 584, "prop" : { "x" : 1185, "y" : 553, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1189, "y" : 558 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1221, "y" : 558 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1221, "y" : 558 } } }, "connectors" : [ { "edgeId" : 98259, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1229, "y" : 561 }, "to" : { "x" : 1269, "y" : 548 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1234, "y" : 555 }, "b" : { "x" : 1229, "y" : 561 }, "c" : { "x" : 1237, "y" : 563 }, "type" : "ARROW", "centre" : { "x" : 1237, "y" : 563 } } } ] }, { "id" : 98260, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1095, "y" : 493 }, "minX" : 1075, "maxX" : 1192, "minY" : 477, "maxY" : 508, "prop" : { "x" : 1075, "y" : 478, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1079, "y" : 482 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1110, "y" : 483 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1110, "y" : 483 } } }, "connectors" : [ { "edgeId" : 98259, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1118, "y" : 494 }, "to" : { "x" : 1192, "y" : 500 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98262, "reactomeId" : 10597961, "displayName" : "ipmkb", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1250, "y" : 487 }, "minX" : 1232, "maxX" : 1275, "minY" : 470, "maxY" : 518, "prop" : { "x" : 1232, "y" : 476, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 1232, "y" : 470 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1269, "y" : 476 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1269, "y" : 476 } } }, "connectors" : [ { "edgeId" : 98259, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1245, "y" : 501 }, "to" : { "x" : 1241, "y" : 510 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1240, "y" : 514 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1240, "y" : 514 } } } ] }, { "id" : 98264, "reactomeId" : 9668967, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1408, "y" : 746 }, "minX" : 1351, "maxX" : 1426, "minY" : 732, "maxY" : 760, "prop" : { "x" : 1391, "y" : 733, "width" : 34, "height" : 27 }, "textPosition" : { "x" : 1394, "y" : 736 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1420, "y" : 738 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1420, "y" : 738 } } }, "connectors" : [ { "edgeId" : 98263, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1388, "y" : 746 }, "to" : { "x" : 1351, "y" : 748 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1381, "y" : 750 }, "b" : { "x" : 1388, "y" : 746 }, "c" : { "x" : 1381, "y" : 742 }, "type" : "ARROW", "centre" : { "x" : 1381, "y" : 742 } } } ], "trivial" : true }, { "id" : 98267, "reactomeId" : 2023929, "displayName" : "IP6", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1597, "y" : 783 }, "minX" : 1567, "maxX" : 1616, "minY" : 669, "maxY" : 822, "prop" : { "x" : 1580, "y" : 768, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1584, "y" : 772 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1610, "y" : 773 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1610, "y" : 773 } } }, "connectors" : [ { "edgeId" : 98265, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1593, "y" : 765 }, "to" : { "x" : 1567, "y" : 669 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1587, "y" : 759 }, "b" : { "x" : 1593, "y" : 765 }, "c" : { "x" : 1595, "y" : 757 }, "type" : "ARROW", "centre" : { "x" : 1595, "y" : 757 } } }, { "edgeId" : 98280, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1587, "y" : 801 }, "to" : { "x" : 1572, "y" : 822 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98289, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98266, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1423, "y" : 672 }, "minX" : 1403, "maxX" : 1463, "minY" : 639, "maxY" : 687, "prop" : { "x" : 1403, "y" : 657, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1407, "y" : 661 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1438, "y" : 662 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1438, "y" : 662 } } }, "connectors" : [ { "edgeId" : 98265, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1441, "y" : 654 }, "to" : { "x" : 1463, "y" : 639 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98269, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1647, "y" : 671 }, "minX" : 1567, "maxX" : 1669, "minY" : 655, "maxY" : 686, "prop" : { "x" : 1627, "y" : 656, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1631, "y" : 660 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1663, "y" : 661 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1663, "y" : 661 } } }, "connectors" : [ { "edgeId" : 98265, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1624, "y" : 670 }, "to" : { "x" : 1567, "y" : 669 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1617, "y" : 674 }, "b" : { "x" : 1624, "y" : 670 }, "c" : { "x" : 1617, "y" : 666 }, "type" : "ARROW", "centre" : { "x" : 1617, "y" : 666 } } } ] }, { "id" : 98268, "reactomeId" : 9668967, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1633, "y" : 716 }, "minX" : 1567, "maxX" : 1654, "minY" : 669, "maxY" : 730, "prop" : { "x" : 1614, "y" : 703, "width" : 39, "height" : 27 }, "textPosition" : { "x" : 1620, "y" : 706 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1648, "y" : 708 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1648, "y" : 708 } } }, "connectors" : [ { "edgeId" : 98265, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1614, "y" : 700 }, "to" : { "x" : 1567, "y" : 669 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1606, "y" : 700 }, "b" : { "x" : 1614, "y" : 700 }, "c" : { "x" : 1610, "y" : 693 }, "type" : "ARROW", "centre" : { "x" : 1610, "y" : 693 } } } ], "trivial" : true }, { "id" : 98270, "reactomeId" : 10597938, "displayName" : "ippk", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1505, "y" : 697 }, "minX" : 1488, "maxX" : 1528, "minY" : 657, "maxY" : 708, "prop" : { "x" : 1488, "y" : 686, "width" : 34, "height" : 22 }, "textPosition" : { "x" : 1488, "y" : 686 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1522, "y" : 686 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1522, "y" : 686 } } }, "connectors" : [ { "edgeId" : 98265, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1505, "y" : 683 }, "to" : { "x" : 1506, "y" : 665 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1506, "y" : 661 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1506, "y" : 661 } } } ] }, { "id" : 98273, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1618, "y" : 577 }, "minX" : 1570, "maxX" : 1642, "minY" : 563, "maxY" : 591, "prop" : { "x" : 1596, "y" : 564, "width" : 45, "height" : 27 }, "textPosition" : { "x" : 1602, "y" : 567 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1636, "y" : 569 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1636, "y" : 569 } } }, "connectors" : [ { "edgeId" : 98271, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1593, "y" : 570 }, "to" : { "x" : 1570, "y" : 564 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1585, "y" : 572 }, "b" : { "x" : 1593, "y" : 570 }, "c" : { "x" : 1587, "y" : 564 }, "type" : "ARROW", "centre" : { "x" : 1587, "y" : 564 } } } ] }, { "id" : 98272, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1400, "y" : 529 }, "minX" : 1380, "maxX" : 1433, "minY" : 513, "maxY" : 565, "prop" : { "x" : 1380, "y" : 514, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1384, "y" : 518 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1415, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1415, "y" : 519 } } }, "connectors" : [ { "edgeId" : 98271, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1413, "y" : 547 }, "to" : { "x" : 1433, "y" : 565 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98275, "reactomeId" : 10597860, "displayName" : "IP6K1/2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1486, "y" : 374 }, "minX" : 1458, "maxX" : 1593, "minY" : 327, "maxY" : 556, "prop" : { "x" : 1458, "y" : 363, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1459, "y" : 363 }, "connectors" : [ { "edgeId" : 98271, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1487, "y" : 391 }, "to" : { "x" : 1510, "y" : 548 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1510, "y" : 552 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1510, "y" : 552 } } }, { "edgeId" : 98276, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1512, "y" : 357 }, "to" : { "x" : 1585, "y" : 332 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1589, "y" : 331 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1589, "y" : 331 } } } ] }, { "id" : 98274, "reactomeId" : 2023922, "displayName" : "5-PP-IP4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1570, "y" : 393 }, "minX" : 1535, "maxX" : 1607, "minY" : 353, "maxY" : 564, "prop" : { "x" : 1535, "y" : 378, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 1541, "y" : 382 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1601, "y" : 383 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1601, "y" : 383 } } }, "connectors" : [ { "edgeId" : 98341, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98271, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1570, "y" : 411 }, "to" : { "x" : 1570, "y" : 564 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1574, "y" : 418 }, "b" : { "x" : 1570, "y" : 411 }, "c" : { "x" : 1566, "y" : 418 }, "type" : "ARROW", "centre" : { "x" : 1566, "y" : 418 } } }, { "edgeId" : 98276, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1580, "y" : 375 }, "to" : { "x" : 1599, "y" : 353 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98277, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1652, "y" : 365 }, "minX" : 1599, "maxX" : 1672, "minY" : 349, "maxY" : 380, "prop" : { "x" : 1634, "y" : 350, "width" : 37, "height" : 30 }, "textPosition" : { "x" : 1637, "y" : 354 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1666, "y" : 355 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1666, "y" : 355 } } }, "connectors" : [ { "edgeId" : 98276, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1631, "y" : 360 }, "to" : { "x" : 1599, "y" : 353 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98279, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1649, "y" : 252 }, "minX" : 1600, "maxX" : 1671, "minY" : 236, "maxY" : 291, "prop" : { "x" : 1629, "y" : 237, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1633, "y" : 241 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1665, "y" : 242 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1665, "y" : 242 } } }, "connectors" : [ { "edgeId" : 98276, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1630, "y" : 270 }, "to" : { "x" : 1600, "y" : 291 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1627, "y" : 277 }, "b" : { "x" : 1630, "y" : 270 }, "c" : { "x" : 1622, "y" : 271 }, "type" : "ARROW", "centre" : { "x" : 1622, "y" : 271 } } } ] }, { "id" : 98278, "reactomeId" : 2023948, "displayName" : "1,5-(PP)2-IP3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1541, "y" : 242 }, "minX" : 1489, "maxX" : 1600, "minY" : 226, "maxY" : 291, "prop" : { "x" : 1489, "y" : 227, "width" : 105, "height" : 30 }, "textPosition" : { "x" : 1497, "y" : 231 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1589, "y" : 232 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1589, "y" : 232 } } }, "connectors" : [ { "edgeId" : 98276, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1559, "y" : 260 }, "to" : { "x" : 1600, "y" : 291 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1567, "y" : 261 }, "b" : { "x" : 1559, "y" : 260 }, "c" : { "x" : 1562, "y" : 267 }, "type" : "ARROW", "centre" : { "x" : 1562, "y" : 267 } } } ] }, { "id" : 98281, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1531, "y" : 809 }, "minX" : 1511, "maxX" : 1572, "minY" : 793, "maxY" : 824, "prop" : { "x" : 1511, "y" : 794, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1515, "y" : 798 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1546, "y" : 799 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1546, "y" : 799 } } }, "connectors" : [ { "edgeId" : 98280, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1554, "y" : 815 }, "to" : { "x" : 1572, "y" : 822 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98283, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1526, "y" : 909 }, "minX" : 1506, "maxX" : 1572, "minY" : 885, "maxY" : 924, "prop" : { "x" : 1506, "y" : 894, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1510, "y" : 898 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1542, "y" : 899 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1542, "y" : 899 } } }, "connectors" : [ { "edgeId" : 98280, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1550, "y" : 898 }, "to" : { "x" : 1572, "y" : 885 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1554, "y" : 891 }, "b" : { "x" : 1550, "y" : 898 }, "c" : { "x" : 1558, "y" : 898 }, "type" : "ARROW", "centre" : { "x" : 1558, "y" : 898 } } } ] }, { "id" : 98282, "reactomeId" : 2023940, "displayName" : "5-PP-IP5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1603, "y" : 925 }, "minX" : 1529, "maxX" : 1640, "minY" : 885, "maxY" : 954, "prop" : { "x" : 1568, "y" : 910, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 1574, "y" : 914 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1634, "y" : 915 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1634, "y" : 915 } } }, "connectors" : [ { "edgeId" : 98280, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1591, "y" : 907 }, "to" : { "x" : 1572, "y" : 885 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1583, "y" : 904 }, "b" : { "x" : 1591, "y" : 907 }, "c" : { "x" : 1589, "y" : 899 }, "type" : "ARROW", "centre" : { "x" : 1589, "y" : 899 } } }, { "edgeId" : 98285, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1565, "y" : 938 }, "to" : { "x" : 1529, "y" : 954 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98292, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98284, "reactomeId" : 10597860, "displayName" : "IP6K1/2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1470, "y" : 880 }, "minX" : 1442, "maxX" : 1565, "minY" : 846, "maxY" : 946, "prop" : { "x" : 1442, "y" : 869, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1443, "y" : 869 }, "connectors" : [ { "edgeId" : 98280, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1505, "y" : 870 }, "to" : { "x" : 1557, "y" : 851 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1561, "y" : 850 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1561, "y" : 850 } } }, { "edgeId" : 98285, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1473, "y" : 897 }, "to" : { "x" : 1487, "y" : 938 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1488, "y" : 942 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1488, "y" : 942 } } } ] }, { "id" : 98287, "reactomeId" : 2023941, "displayName" : "5-PPP-IP5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1381, "y" : 925 }, "minX" : 1342, "maxX" : 1462, "minY" : 909, "maxY" : 953, "prop" : { "x" : 1342, "y" : 910, "width" : 78, "height" : 30 }, "textPosition" : { "x" : 1347, "y" : 914 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1415, "y" : 915 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1415, "y" : 915 } } }, "connectors" : [ { "edgeId" : 98285, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1423, "y" : 938 }, "to" : { "x" : 1462, "y" : 953 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1431, "y" : 937 }, "b" : { "x" : 1423, "y" : 938 }, "c" : { "x" : 1428, "y" : 944 }, "type" : "ARROW", "centre" : { "x" : 1428, "y" : 944 } } } ] }, { "id" : 98286, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1595, "y" : 994 }, "minX" : 1529, "maxX" : 1616, "minY" : 954, "maxY" : 1009, "prop" : { "x" : 1575, "y" : 979, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1579, "y" : 983 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1610, "y" : 984 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1610, "y" : 984 } } }, "connectors" : [ { "edgeId" : 98285, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1572, "y" : 981 }, "to" : { "x" : 1529, "y" : 954 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98288, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1419, "y" : 993 }, "minX" : 1399, "maxX" : 1462, "minY" : 953, "maxY" : 1008, "prop" : { "x" : 1399, "y" : 978, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1403, "y" : 982 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1435, "y" : 983 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1435, "y" : 983 } } }, "connectors" : [ { "edgeId" : 98285, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1435, "y" : 975 }, "to" : { "x" : 1462, "y" : 953 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1438, "y" : 968 }, "b" : { "x" : 1435, "y" : 975 }, "c" : { "x" : 1443, "y" : 974 }, "type" : "ARROW", "centre" : { "x" : 1443, "y" : 974 } } } ] }, { "id" : 98291, "reactomeId" : 10564682, "displayName" : "Nuclear Pore Complex (NPC)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1677, "y" : 857 }, "minX" : 1644, "maxX" : 1716, "minY" : 792, "maxY" : 916, "prop" : { "x" : 1644, "y" : 828, "width" : 66, "height" : 59 }, "textPosition" : { "x" : 1645, "y" : 824 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1710, "y" : 828 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1710, "y" : 828 } } }, "connectors" : [ { "edgeId" : 98289, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1685, "y" : 825 }, "to" : { "x" : 1693, "y" : 799 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1694, "y" : 796 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1694, "y" : 796 } } }, { "edgeId" : 98292, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1686, "y" : 890 }, "to" : { "x" : 1693, "y" : 908 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1695, "y" : 912 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1695, "y" : 912 } } } ] }, { "id" : 98290, "reactomeId" : 1629770, "displayName" : "IP6", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1790, "y" : 786 }, "minX" : 1765, "maxX" : 1942, "minY" : 731, "maxY" : 828, "prop" : { "x" : 1773, "y" : 771, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1777, "y" : 775 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1803, "y" : 776 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1803, "y" : 776 } } }, "connectors" : [ { "edgeId" : 98322, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1781, "y" : 804 }, "to" : { "x" : 1765, "y" : 828 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1780, "y" : 812 }, "b" : { "x" : 1781, "y" : 804 }, "c" : { "x" : 1774, "y" : 808 }, "type" : "ARROW", "centre" : { "x" : 1774, "y" : 808 } } }, { "edgeId" : 98326, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1811, "y" : 796 }, "to" : { "x" : 1851, "y" : 823 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98334, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1811, "y" : 783 }, "to" : { "x" : 1942, "y" : 768 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1817, "y" : 778 }, "b" : { "x" : 1811, "y" : 783 }, "c" : { "x" : 1818, "y" : 786 }, "type" : "ARROW", "centre" : { "x" : 1818, "y" : 786 } } }, { "edgeId" : 98349, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1787, "y" : 768 }, "to" : { "x" : 1779, "y" : 731 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1782, "y" : 762 }, "b" : { "x" : 1787, "y" : 768 }, "c" : { "x" : 1789, "y" : 760 }, "type" : "ARROW", "centre" : { "x" : 1789, "y" : 760 } } }, { "edgeId" : 98289, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98293, "reactomeId" : 1629765, "displayName" : "5-PP-IP5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1809, "y" : 923 }, "minX" : 1738, "maxX" : 1895, "minY" : 882, "maxY" : 965, "prop" : { "x" : 1774, "y" : 908, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 1780, "y" : 912 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1840, "y" : 913 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1840, "y" : 913 } } }, "connectors" : [ { "edgeId" : 98322, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1792, "y" : 905 }, "to" : { "x" : 1765, "y" : 882 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98326, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1825, "y" : 905 }, "to" : { "x" : 1852, "y" : 884 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1828, "y" : 898 }, "b" : { "x" : 1825, "y" : 905 }, "c" : { "x" : 1833, "y" : 904 }, "type" : "ARROW", "centre" : { "x" : 1833, "y" : 904 } } }, { "edgeId" : 98330, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1848, "y" : 922 }, "to" : { "x" : 1895, "y" : 922 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98292, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98300, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1783, "y" : 941 }, "to" : { "x" : 1738, "y" : 965 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1779, "y" : 948 }, "b" : { "x" : 1783, "y" : 941 }, "c" : { "x" : 1775, "y" : 941 }, "type" : "ARROW", "centre" : { "x" : 1775, "y" : 941 } } } ] }, { "id" : 98295, "reactomeId" : 1629740, "displayName" : "1-PP-IP5", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1954, "y" : 1254 }, "minX" : 1920, "maxX" : 1990, "minY" : 1186, "maxY" : 1269, "prop" : { "x" : 1920, "y" : 1239, "width" : 69, "height" : 30 }, "textPosition" : { "x" : 1925, "y" : 1243 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1984, "y" : 1244 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1984, "y" : 1244 } } }, "connectors" : [ { "edgeId" : 98294, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1950, "y" : 1236 }, "to" : { "x" : 1940, "y" : 1186 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98297, "reactomeId" : 1629732, "displayName" : "1,5-(PP)2-IP4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1939, "y" : 1099 }, "minX" : 1889, "maxX" : 1991, "minY" : 1083, "maxY" : 1135, "prop" : { "x" : 1889, "y" : 1084, "width" : 101, "height" : 30 }, "textPosition" : { "x" : 1895, "y" : 1088 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1985, "y" : 1089 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1985, "y" : 1089 } } }, "connectors" : [ { "edgeId" : 98294, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1939, "y" : 1117 }, "to" : { "x" : 1940, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1943, "y" : 1124 }, "b" : { "x" : 1939, "y" : 1117 }, "c" : { "x" : 1935, "y" : 1124 }, "type" : "ARROW", "centre" : { "x" : 1935, "y" : 1124 } } } ] }, { "id" : 98296, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1892, "y" : 1214 }, "minX" : 1874, "maxX" : 1940, "minY" : 1186, "maxY" : 1229, "prop" : { "x" : 1874, "y" : 1199, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1876, "y" : 1203 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1905, "y" : 1204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1905, "y" : 1204 } } }, "connectors" : [ { "edgeId" : 98294, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1913, "y" : 1203 }, "to" : { "x" : 1940, "y" : 1186 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98299, "reactomeId" : 10597865, "displayName" : "ip6k1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1873, "y" : 1159 }, "minX" : 1845, "maxX" : 1931, "minY" : 1142, "maxY" : 1170, "prop" : { "x" : 1845, "y" : 1148, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1852, "y" : 1148 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1902, "y" : 1148 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1902, "y" : 1148 } } }, "connectors" : [ { "edgeId" : 98294, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1908, "y" : 1159 }, "to" : { "x" : 1923, "y" : 1160 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1927, "y" : 1160 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1927, "y" : 1160 } } } ] }, { "id" : 98298, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1995, "y" : 1136 }, "minX" : 1940, "maxX" : 2017, "minY" : 1120, "maxY" : 1151, "prop" : { "x" : 1975, "y" : 1121, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1979, "y" : 1125 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2011, "y" : 1126 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2011, "y" : 1126 } } }, "connectors" : [ { "edgeId" : 98294, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1972, "y" : 1135 }, "to" : { "x" : 1940, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1965, "y" : 1139 }, "b" : { "x" : 1972, "y" : 1135 }, "c" : { "x" : 1965, "y" : 1131 }, "type" : "ARROW", "centre" : { "x" : 1965, "y" : 1131 } } } ] }, { "id" : 98301, "reactomeId" : 2023968, "displayName" : "(PP)2-IP4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1823, "y" : 1100 }, "minX" : 1739, "maxX" : 1859, "minY" : 1043, "maxY" : 1147, "prop" : { "x" : 1787, "y" : 1085, "width" : 72, "height" : 30 }, "textPosition" : { "x" : 1790, "y" : 1089 }, "connectors" : [ { "edgeId" : 98305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1823, "y" : 1121 }, "to" : { "x" : 1823, "y" : 1147 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98313, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98300, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1800, "y" : 1079 }, "to" : { "x" : 1739, "y" : 1043 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98303, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1793, "y" : 962 }, "minX" : 1738, "maxX" : 1809, "minY" : 946, "maxY" : 977, "prop" : { "x" : 1778, "y" : 947, "width" : 30, "height" : 30 }, "textPosition" : { "x" : 1783, "y" : 951 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1803, "y" : 952 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1803, "y" : 952 } } }, "connectors" : [ { "edgeId" : 98300, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1775, "y" : 962 }, "to" : { "x" : 1738, "y" : 965 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1768, "y" : 967 }, "b" : { "x" : 1775, "y" : 962 }, "c" : { "x" : 1768, "y" : 959 }, "type" : "ARROW", "centre" : { "x" : 1768, "y" : 959 } } } ] }, { "id" : 98302, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1790, "y" : 1051 }, "minX" : 1739, "maxX" : 1813, "minY" : 1035, "maxY" : 1066, "prop" : { "x" : 1769, "y" : 1036, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1773, "y" : 1040 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1807, "y" : 1041 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1807, "y" : 1041 } } }, "connectors" : [ { "edgeId" : 98300, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1766, "y" : 1047 }, "to" : { "x" : 1739, "y" : 1043 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true } ], "edges" : [ { "id" : 98305, "reactomeId" : 10600198, "displayName" : "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1822, "y" : 1176 }, "minX" : 1816, "maxX" : 1828, "minY" : 1147, "maxY" : 1207, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1823, "y" : 1147 }, "to" : { "x" : 1822, "y" : 1176 } }, { "from" : { "x" : 1822, "y" : 1176 }, "to" : { "x" : 1823, "y" : 1207 } } ], "reactionShape" : { "a" : { "x" : 1816, "y" : 1170 }, "b" : { "x" : 1828, "y" : 1182 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1822, "y" : 1176 } }, "inputs" : [ { "id" : 98301, "points" : [ { "x" : 1823, "y" : 1121 } ] }, { "id" : 98306, "points" : [ { "x" : 1792, "y" : 1136 } ] } ], "outputs" : [ { "id" : 98307, "points" : [ { "x" : 1835, "y" : 1233 } ] }, { "id" : 98308, "points" : [ { "x" : 1781, "y" : 1226 } ] } ], "catalysts" : [ { "id" : 98309, "points" : [ { "x" : 1790, "y" : 1174 } ] } ] }, { "id" : 98176, "reactomeId" : 10597934, "displayName" : "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 505, "y" : 191 }, "minX" : 460, "maxX" : 586, "minY" : 185, "maxY" : 216, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 586, "y" : 216 }, "to" : { "x" : 505, "y" : 191 } }, { "from" : { "x" : 505, "y" : 191 }, "to" : { "x" : 460, "y" : 190 } } ], "reactionShape" : { "a" : { "x" : 499, "y" : 185 }, "b" : { "x" : 511, "y" : 197 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 505, "y" : 191 } }, "inputs" : [ { "id" : 98177, "points" : [ { "x" : 597, "y" : 187 } ] }, { "id" : 98153, "points" : [ { "x" : 643, "y" : 204 } ] } ], "outputs" : [ { "id" : 98178, "points" : [ { "x" : 384, "y" : 155 } ] }, { "id" : 98179, "points" : [ { "x" : 414, "y" : 212 } ] } ], "catalysts" : [ { "id" : 98180, "points" : [ { "x" : 506, "y" : 205 } ] } ] }, { "id" : 98181, "reactomeId" : 10598063, "displayName" : "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 477, "y" : 165 }, "minX" : 452, "maxX" : 603, "minY" : 159, "maxY" : 203, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 603, "y" : 203 }, "to" : { "x" : 477, "y" : 165 } }, { "from" : { "x" : 477, "y" : 165 }, "to" : { "x" : 452, "y" : 164 } } ], "reactionShape" : { "a" : { "x" : 471, "y" : 159 }, "b" : { "x" : 483, "y" : 171 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 477, "y" : 165 } }, "inputs" : [ { "id" : 98153, "points" : [ { "x" : 643, "y" : 200 } ] }, { "id" : 98177, "points" : [ { "x" : 603, "y" : 187 } ] } ], "outputs" : [ { "id" : 98178, "points" : [ { "x" : 390, "y" : 145 } ] }, { "id" : 98179, "points" : [ { "x" : 411, "y" : 202 } ] } ], "catalysts" : [ { "id" : 98182, "points" : [ { "x" : 411, "y" : 34 } ] } ] }, { "id" : 98183, "reactomeId" : 10598010, "displayName" : "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 258, "y" : 177 }, "minX" : 225, "maxX" : 292, "minY" : 171, "maxY" : 183, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 292, "y" : 177 }, "to" : { "x" : 258, "y" : 177 } }, { "from" : { "x" : 258, "y" : 177 }, "to" : { "x" : 225, "y" : 176 } } ], "reactionShape" : { "a" : { "x" : 252, "y" : 171 }, "b" : { "x" : 264, "y" : 183 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 258, "y" : 177 } }, "inputs" : [ { "id" : 98184, "points" : [ { "x" : 315, "y" : 193 } ] }, { "id" : 98178, "points" : [ { "x" : 331, "y" : 155 } ] } ], "outputs" : [ { "id" : 98171, "points" : [ { "x" : 194, "y" : 196 } ] }, { "id" : 98185, "points" : [ { "x" : 205, "y" : 157 } ] } ], "catalysts" : [ { "id" : 98186, "points" : [ { "x" : 256, "y" : 140 } ] } ] }, { "id" : 98310, "reactomeId" : 10598018, "displayName" : "1/3-PP-IP5 transports from the cytosol to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1698, "y" : 1254 }, "minX" : 1676, "maxX" : 1793, "minY" : 1248, "maxY" : 1260, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1793, "y" : 1254 }, "to" : { "x" : 1698, "y" : 1254 } }, { "from" : { "x" : 1698, "y" : 1254 }, "to" : { "x" : 1676, "y" : 1254 } } ], "endShape" : { "a" : { "x" : 1683, "y" : 1250 }, "b" : { "x" : 1676, "y" : 1254 }, "c" : { "x" : 1683, "y" : 1258 }, "type" : "ARROW", "centre" : { "x" : 1683, "y" : 1258 } }, "reactionShape" : { "a" : { "x" : 1692, "y" : 1248 }, "b" : { "x" : 1704, "y" : 1260 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1698, "y" : 1254 } }, "inputs" : [ { "id" : 98307 } ], "outputs" : [ { "id" : 98311 } ], "catalysts" : [ { "id" : 98312, "points" : [ { "x" : 1694, "y" : 1206 } ] } ] }, { "id" : 98313, "reactomeId" : 10598037, "displayName" : "(PP)2-IP4 transports from the nucleus to the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1697, "y" : 1098 }, "minX" : 1668, "maxX" : 1781, "minY" : 1092, "maxY" : 1104, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1668, "y" : 1098 }, "to" : { "x" : 1697, "y" : 1098 } }, { "from" : { "x" : 1697, "y" : 1098 }, "to" : { "x" : 1781, "y" : 1099 } } ], "endShape" : { "a" : { "x" : 1774, "y" : 1103 }, "b" : { "x" : 1781, "y" : 1099 }, "c" : { "x" : 1774, "y" : 1095 }, "type" : "ARROW", "centre" : { "x" : 1774, "y" : 1095 } }, "reactionShape" : { "a" : { "x" : 1691, "y" : 1092 }, "b" : { "x" : 1703, "y" : 1104 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1697, "y" : 1098 } }, "inputs" : [ { "id" : 98314 } ], "outputs" : [ { "id" : 98301 } ], "catalysts" : [ { "id" : 98312, "points" : [ { "x" : 1694, "y" : 1140 } ] } ] }, { "id" : 98315, "reactomeId" : 10597863, "displayName" : "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1466, "y" : 1171 }, "minX" : 1460, "maxX" : 1472, "minY" : 1138, "maxY" : 1206, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1465, "y" : 1206 }, "to" : { "x" : 1466, "y" : 1171 } }, { "from" : { "x" : 1466, "y" : 1171 }, "to" : { "x" : 1467, "y" : 1138 } } ], "reactionShape" : { "a" : { "x" : 1460, "y" : 1165 }, "b" : { "x" : 1472, "y" : 1177 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1466, "y" : 1171 } }, "inputs" : [ { "id" : 98316, "points" : [ { "x" : 1499, "y" : 1236 } ] }, { "id" : 98317, "points" : [ { "x" : 1412, "y" : 1211 } ] }, { "id" : 98318, "points" : [ { "x" : 1441, "y" : 1244 } ] } ], "outputs" : [ { "id" : 98319, "points" : [ { "x" : 1434, "y" : 1112 } ] }, { "id" : 98320, "points" : [ { "x" : 1496, "y" : 1116 } ] } ], "catalysts" : [ { "id" : 98321, "points" : [ { "x" : 1507, "y" : 1171 } ] } ] }, { "id" : 98187, "reactomeId" : 10597850, "displayName" : "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 266, "y" : 413 }, "minX" : 219, "maxX" : 319, "minY" : 407, "maxY" : 419, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 319, "y" : 414 }, "to" : { "x" : 266, "y" : 413 } }, { "from" : { "x" : 266, "y" : 413 }, "to" : { "x" : 219, "y" : 412 } } ], "reactionShape" : { "a" : { "x" : 260, "y" : 407 }, "b" : { "x" : 272, "y" : 419 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 266, "y" : 413 } }, "inputs" : [ { "id" : 98188, "points" : [ { "x" : 362, "y" : 366 } ] }, { "id" : 98189, "points" : [ { "x" : 347, "y" : 421 } ] } ], "outputs" : [ { "id" : 98174, "points" : [ { "x" : 186, "y" : 385 } ] }, { "id" : 98190, "points" : [ { "x" : 209, "y" : 422 } ] } ], "catalysts" : [ { "id" : 98175, "points" : [ { "x" : 265, "y" : 308 } ] } ] }, { "id" : 98191, "reactomeId" : 10598013, "displayName" : "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 120, "y" : 464 }, "minX" : 114, "maxX" : 126, "minY" : 394, "maxY" : 527, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 119, "y" : 527 }, "to" : { "x" : 120, "y" : 464 } }, { "from" : { "x" : 120, "y" : 464 }, "to" : { "x" : 120, "y" : 394 } } ], "reactionShape" : { "a" : { "x" : 114, "y" : 458 }, "b" : { "x" : 126, "y" : 470 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 120, "y" : 464 } }, "inputs" : [ { "id" : 98192, "points" : [ { "x" : 96, "y" : 527 } ] }, { "id" : 98193, "points" : [ { "x" : 154, "y" : 527 } ] } ], "outputs" : [ { "id" : 98173, "points" : [ { "x" : 85, "y" : 374 } ] }, { "id" : 98174, "points" : [ { "x" : 148, "y" : 377 } ] } ], "catalysts" : [ { "id" : 98194, "points" : [ { "x" : 96, "y" : 462 } ] } ] }, { "id" : 98195, "reactomeId" : 10597988, "displayName" : "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 274, "y" : 464 }, "minX" : 209, "maxX" : 324, "minY" : 458, "maxY" : 470, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 324, "y" : 465 }, "to" : { "x" : 274, "y" : 464 } }, { "from" : { "x" : 274, "y" : 464 }, "to" : { "x" : 209, "y" : 465 } } ], "reactionShape" : { "a" : { "x" : 268, "y" : 458 }, "b" : { "x" : 280, "y" : 470 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 274, "y" : 464 } }, "inputs" : [ { "id" : 98196, "points" : [ { "x" : 355, "y" : 512 } ] }, { "id" : 98189, "points" : [ { "x" : 352, "y" : 444 } ] } ], "outputs" : [ { "id" : 98193, "points" : [ { "x" : 182, "y" : 510 } ] }, { "id" : 98190, "points" : [ { "x" : 200, "y" : 453 } ] } ], "catalysts" : [ { "id" : 98197, "points" : [ { "x" : 274, "y" : 501 } ] } ] }, { "id" : 98322, "reactomeId" : 10597980, "displayName" : "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1764, "y" : 853 }, "minX" : 1758, "maxX" : 1770, "minY" : 828, "maxY" : 882, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1765, "y" : 882 }, "to" : { "x" : 1764, "y" : 853 } }, { "from" : { "x" : 1764, "y" : 853 }, "to" : { "x" : 1765, "y" : 828 } } ], "reactionShape" : { "a" : { "x" : 1758, "y" : 847 }, "b" : { "x" : 1770, "y" : 859 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1764, "y" : 853 } }, "inputs" : [ { "id" : 98323, "points" : [ { "x" : 1758, "y" : 888 } ] }, { "id" : 98293, "points" : [ { "x" : 1792, "y" : 905 } ] } ], "outputs" : [ { "id" : 98290, "points" : [ { "x" : 1781, "y" : 804 } ] }, { "id" : 98324, "points" : [ { "x" : 1743, "y" : 814 } ] } ], "catalysts" : [ { "id" : 98325, "points" : [ { "x" : 1784, "y" : 853 } ] } ] }, { "id" : 98326, "reactomeId" : 10598075, "displayName" : "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1851, "y" : 854 }, "minX" : 1845, "maxX" : 1857, "minY" : 823, "maxY" : 884, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1851, "y" : 823 }, "to" : { "x" : 1851, "y" : 854 } }, { "from" : { "x" : 1851, "y" : 854 }, "to" : { "x" : 1852, "y" : 884 } } ], "reactionShape" : { "a" : { "x" : 1845, "y" : 848 }, "b" : { "x" : 1857, "y" : 860 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1851, "y" : 854 } }, "inputs" : [ { "id" : 98327, "points" : [ { "x" : 1869, "y" : 814 } ] }, { "id" : 98290, "points" : [ { "x" : 1811, "y" : 796 } ] } ], "outputs" : [ { "id" : 98293, "points" : [ { "x" : 1825, "y" : 905 } ] }, { "id" : 98328, "points" : [ { "x" : 1867, "y" : 889 } ] } ], "catalysts" : [ { "id" : 98329, "points" : [ { "x" : 1893, "y" : 854 } ] } ] }, { "id" : 98198, "reactomeId" : 10598084, "displayName" : "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 536, "y" : 582 }, "minX" : 405, "maxX" : 594, "minY" : 576, "maxY" : 588, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 594, "y" : 582 }, "to" : { "x" : 536, "y" : 582 } }, { "from" : { "x" : 536, "y" : 582 }, "to" : { "x" : 405, "y" : 581 } } ], "reactionShape" : { "a" : { "x" : 530, "y" : 576 }, "b" : { "x" : 542, "y" : 588 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 536, "y" : 582 } }, "inputs" : [ { "id" : 98199, "points" : [ { "x" : 657, "y" : 613 } ] }, { "id" : 98200, "points" : [ { "x" : 617, "y" : 556 } ] } ], "outputs" : [ { "id" : 98196, "points" : [ { "x" : 376, "y" : 548 } ] }, { "id" : 98201, "points" : [ { "x" : 383, "y" : 605 } ] } ], "catalysts" : [ { "id" : 98202, "points" : [ { "x" : 533, "y" : 552 } ] } ] }, { "id" : 98203, "reactomeId" : 10597954, "displayName" : "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 630, "y" : 731 }, "minX" : 624, "maxX" : 636, "minY" : 685, "maxY" : 788, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 631, "y" : 685 }, "to" : { "x" : 630, "y" : 731 } }, { "from" : { "x" : 630, "y" : 731 }, "to" : { "x" : 630, "y" : 788 } } ], "reactionShape" : { "a" : { "x" : 624, "y" : 725 }, "b" : { "x" : 636, "y" : 737 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 630, "y" : 731 } }, "inputs" : [ { "id" : 98199, "points" : [ { "x" : 670, "y" : 649 } ] }, { "id" : 98204, "points" : [ { "x" : 603, "y" : 652 } ] } ], "outputs" : [ { "id" : 98205, "points" : [ { "x" : 597, "y" : 805 } ] }, { "id" : 98206, "points" : [ { "x" : 647, "y" : 814 } ] } ], "catalysts" : [ { "id" : 98207, "points" : [ { "x" : 599, "y" : 731 } ] } ] }, { "id" : 98330, "reactomeId" : 10597870, "displayName" : "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1928, "y" : 922 }, "minX" : 1895, "maxX" : 1962, "minY" : 916, "maxY" : 928, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1895, "y" : 922 }, "to" : { "x" : 1928, "y" : 922 } }, { "from" : { "x" : 1928, "y" : 922 }, "to" : { "x" : 1962, "y" : 922 } } ], "reactionShape" : { "a" : { "x" : 1922, "y" : 916 }, "b" : { "x" : 1934, "y" : 928 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1928, "y" : 922 } }, "inputs" : [ { "id" : 98293, "points" : [ { "x" : 1848, "y" : 922 } ] }, { "id" : 98331, "points" : [ { "x" : 1882, "y" : 939 } ] } ], "outputs" : [ { "id" : 98332, "points" : [ { "x" : 1991, "y" : 922 } ] }, { "id" : 98333, "points" : [ { "x" : 1973, "y" : 943 } ] } ], "catalysts" : [ { "id" : 98329, "points" : [ { "x" : 1927, "y" : 872 } ] } ] }, { "id" : 98334, "reactomeId" : 10600196, "displayName" : "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2113, "y" : 1007 }, "minX" : 1942, "maxX" : 2119, "minY" : 768, "maxY" : 1293, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2004, "y" : 1293 }, "to" : { "x" : 2113, "y" : 1007 } }, { "from" : { "x" : 2113, "y" : 1007 }, "to" : { "x" : 2113, "y" : 888 } }, { "from" : { "x" : 2113, "y" : 888 }, "to" : { "x" : 1942, "y" : 768 } } ], "reactionShape" : { "a" : { "x" : 2107, "y" : 1001 }, "b" : { "x" : 2119, "y" : 1013 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2113, "y" : 1007 } }, "inputs" : [ { "id" : 98335, "points" : [ { "x" : 1968, "y" : 1315 } ] }, { "id" : 98307, "points" : [ { "x" : 1890, "y" : 1264 } ] } ], "outputs" : [ { "id" : 98290, "points" : [ { "x" : 1811, "y" : 783 } ] }, { "id" : 98336, "points" : [ { "x" : 1902, "y" : 759 } ] } ], "catalysts" : [ { "id" : 98337, "points" : [ { "x" : 2138, "y" : 1007 } ] } ] }, { "id" : 98208, "reactomeId" : 10597995, "displayName" : "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 860, "y" : 291 }, "minX" : 801, "maxX" : 872, "minY" : 221, "maxY" : 392, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 872, "y" : 392 }, "to" : { "x" : 860, "y" : 291 } }, { "from" : { "x" : 860, "y" : 291 }, "to" : { "x" : 801, "y" : 221 } } ], "reactionShape" : { "a" : { "x" : 854, "y" : 285 }, "b" : { "x" : 866, "y" : 297 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 860, "y" : 291 } }, "inputs" : [ { "id" : 98209, "points" : [ { "x" : 905, "y" : 400 } ] }, { "id" : 98210, "points" : [ { "x" : 848, "y" : 456 } ] } ], "outputs" : [ { "id" : 98153, "points" : [ { "x" : 720, "y" : 204 } ] }, { "id" : 98211, "points" : [ { "x" : 838, "y" : 221 } ] } ], "catalysts" : [ { "id" : 98212, "points" : [ { "x" : 901, "y" : 281 } ] } ] }, { "id" : 98338, "reactomeId" : 10597878, "displayName" : "I(1,3,4,5,6)P5 transports from the nucleus to the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1695, "y" : 620 }, "minX" : 1427, "maxX" : 1745, "minY" : 614, "maxY" : 626, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1427, "y" : 618 }, "to" : { "x" : 1695, "y" : 620 } }, { "from" : { "x" : 1695, "y" : 620 }, "to" : { "x" : 1745, "y" : 622 } } ], "endShape" : { "a" : { "x" : 1738, "y" : 626 }, "b" : { "x" : 1745, "y" : 622 }, "c" : { "x" : 1738, "y" : 618 }, "type" : "ARROW", "centre" : { "x" : 1738, "y" : 618 } }, "reactionShape" : { "a" : { "x" : 1689, "y" : 614 }, "b" : { "x" : 1701, "y" : 626 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1695, "y" : 620 } }, "inputs" : [ { "id" : 98250 } ], "outputs" : [ { "id" : 98339 } ], "catalysts" : [ { "id" : 98340, "points" : [ { "x" : 1681, "y" : 514 } ] } ] }, { "id" : 98341, "reactomeId" : 10597931, "displayName" : "5-PP-IP4 transports from the nucleus to the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1697, "y" : 393 }, "minX" : 1609, "maxX" : 1743, "minY" : 387, "maxY" : 399, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1609, "y" : 393 }, "to" : { "x" : 1697, "y" : 393 } }, { "from" : { "x" : 1697, "y" : 393 }, "to" : { "x" : 1743, "y" : 393 } } ], "endShape" : { "a" : { "x" : 1736, "y" : 397 }, "b" : { "x" : 1743, "y" : 393 }, "c" : { "x" : 1736, "y" : 389 }, "type" : "ARROW", "centre" : { "x" : 1736, "y" : 389 } }, "reactionShape" : { "a" : { "x" : 1691, "y" : 387 }, "b" : { "x" : 1703, "y" : 399 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1697, "y" : 393 } }, "inputs" : [ { "id" : 98274 } ], "outputs" : [ { "id" : 98342 } ], "catalysts" : [ { "id" : 98340, "points" : [ { "x" : 1684, "y" : 447 } ] } ] }, { "id" : 98213, "reactomeId" : 10598032, "displayName" : "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 770, "y" : 546 }, "minX" : 738, "maxX" : 800, "minY" : 514, "maxY" : 572, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 800, "y" : 514 }, "to" : { "x" : 770, "y" : 546 } }, { "from" : { "x" : 770, "y" : 546 }, "to" : { "x" : 738, "y" : 572 } } ], "reactionShape" : { "a" : { "x" : 764, "y" : 540 }, "b" : { "x" : 776, "y" : 552 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 770, "y" : 546 } }, "inputs" : [ { "id" : 98214, "points" : [ { "x" : 833, "y" : 516 } ] }, { "id" : 98210, "points" : [ { "x" : 826, "y" : 492 } ] } ], "outputs" : [ { "id" : 98199, "points" : [ { "x" : 698, "y" : 613 } ] }, { "id" : 98215, "points" : [ { "x" : 684, "y" : 584 } ] } ], "catalysts" : [ { "id" : 98216, "points" : [ { "x" : 750, "y" : 539 } ] } ] }, { "id" : 98343, "reactomeId" : 10597971, "displayName" : "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1772, "y" : 269 }, "minX" : 1766, "maxX" : 1778, "minY" : 241, "maxY" : 308, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1772, "y" : 308 }, "to" : { "x" : 1772, "y" : 269 } }, { "from" : { "x" : 1772, "y" : 269 }, "to" : { "x" : 1773, "y" : 241 } } ], "reactionShape" : { "a" : { "x" : 1766, "y" : 263 }, "b" : { "x" : 1778, "y" : 275 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1772, "y" : 269 } }, "inputs" : [ { "id" : 98344, "points" : [ { "x" : 1820, "y" : 334 } ] }, { "id" : 98345, "points" : [ { "x" : 1753, "y" : 322 } ] } ], "outputs" : [ { "id" : 98346, "points" : [ { "x" : 1755, "y" : 220 } ] }, { "id" : 98347, "points" : [ { "x" : 1812, "y" : 218 } ] } ], "catalysts" : [ { "id" : 98348, "points" : [ { "x" : 1799, "y" : 267 } ] } ] }, { "id" : 98217, "reactomeId" : 10597929, "displayName" : "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 858, "y" : 557 }, "minX" : 799, "maxX" : 907, "minY" : 506, "maxY" : 605, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 799, "y" : 605 }, "to" : { "x" : 858, "y" : 557 } }, { "from" : { "x" : 858, "y" : 557 }, "to" : { "x" : 907, "y" : 506 } } ], "reactionShape" : { "a" : { "x" : 852, "y" : 551 }, "b" : { "x" : 864, "y" : 563 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 858, "y" : 557 } }, "inputs" : [ { "id" : 98199, "points" : [ { "x" : 726, "y" : 622 } ] }, { "id" : 98218, "points" : [ { "x" : 827, "y" : 630 } ] } ], "outputs" : [ { "id" : 98219, "points" : [ { "x" : 934, "y" : 527 } ] }, { "id" : 98210, "points" : [ { "x" : 873, "y" : 492 } ] }, { "id" : 98220, "points" : [ { "x" : 937, "y" : 492 } ] } ], "catalysts" : [ { "id" : 98221, "points" : [ { "x" : 900, "y" : 571 } ] } ] }, { "id" : 98349, "reactomeId" : 10597951, "displayName" : "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1778, "y" : 695 }, "minX" : 1772, "maxX" : 1784, "minY" : 668, "maxY" : 731, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1779, "y" : 668 }, "to" : { "x" : 1778, "y" : 695 } }, { "from" : { "x" : 1778, "y" : 695 }, "to" : { "x" : 1779, "y" : 731 } } ], "reactionShape" : { "a" : { "x" : 1772, "y" : 689 }, "b" : { "x" : 1784, "y" : 701 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1778, "y" : 695 } }, "inputs" : [ { "id" : 98339, "points" : [ { "x" : 1790, "y" : 642 } ] }, { "id" : 98350, "points" : [ { "x" : 1749, "y" : 656 } ] } ], "outputs" : [ { "id" : 98290, "points" : [ { "x" : 1787, "y" : 768 } ] }, { "id" : 98351, "points" : [ { "x" : 1748, "y" : 746 } ] } ], "catalysts" : [ { "id" : 98352, "points" : [ { "x" : 1745, "y" : 695 } ] } ] }, { "id" : 98222, "reactomeId" : 10597977, "displayName" : "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 782, "y" : 734 }, "minX" : 776, "maxX" : 801, "minY" : 680, "maxY" : 766, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 783, "y" : 680 }, "to" : { "x" : 782, "y" : 734 } }, { "from" : { "x" : 782, "y" : 734 }, "to" : { "x" : 801, "y" : 766 } } ], "reactionShape" : { "a" : { "x" : 776, "y" : 728 }, "b" : { "x" : 788, "y" : 740 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 782, "y" : 734 } }, "inputs" : [ { "id" : 98199, "points" : [ { "x" : 715, "y" : 649 } ] }, { "id" : 98218, "points" : [ { "x" : 820, "y" : 658 } ] } ], "outputs" : [ { "id" : 98223, "points" : [ { "x" : 832, "y" : 799 } ] }, { "id" : 98224, "points" : [ { "x" : 848, "y" : 777 } ] }, { "id" : 98225, "points" : [ { "x" : 835, "y" : 751 } ] } ], "catalysts" : [ { "id" : 98226, "points" : [ { "x" : 816, "y" : 715 } ] } ] }, { "id" : 98353, "reactomeId" : 10597918, "displayName" : "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1847, "y" : 505 }, "minX" : 1841, "maxX" : 1853, "minY" : 471, "maxY" : 570, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1846, "y" : 471 }, "to" : { "x" : 1847, "y" : 505 } }, { "from" : { "x" : 1847, "y" : 505 }, "to" : { "x" : 1847, "y" : 570 } } ], "reactionShape" : { "a" : { "x" : 1841, "y" : 499 }, "b" : { "x" : 1853, "y" : 511 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1847, "y" : 505 } }, "inputs" : [ { "id" : 98354, "points" : [ { "x" : 1893, "y" : 443 } ] }, { "id" : 98355, "points" : [ { "x" : 1846, "y" : 453 } ] } ], "outputs" : [ { "id" : 98339, "points" : [ { "x" : 1810, "y" : 606 } ] }, { "id" : 98356, "points" : [ { "x" : 1828, "y" : 550 } ] } ], "catalysts" : [ { "id" : 98357, "points" : [ { "x" : 1892, "y" : 490 } ] } ] }, { "id" : 98227, "reactomeId" : 10597926, "displayName" : "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 722, "y" : 730 }, "minX" : 716, "maxX" : 728, "minY" : 676, "maxY" : 774, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 723, "y" : 774 }, "to" : { "x" : 722, "y" : 730 } }, { "from" : { "x" : 722, "y" : 730 }, "to" : { "x" : 723, "y" : 676 } } ], "reactionShape" : { "a" : { "x" : 716, "y" : 724 }, "b" : { "x" : 728, "y" : 736 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 722, "y" : 730 } }, "inputs" : [ { "id" : 98228, "points" : [ { "x" : 703, "y" : 782 } ] }, { "id" : 98223, "points" : [ { "x" : 802, "y" : 799 } ] } ], "outputs" : [ { "id" : 98199, "points" : [ { "x" : 697, "y" : 649 } ] }, { "id" : 98229, "points" : [ { "x" : 686, "y" : 686 } ] } ], "catalysts" : [ { "id" : 98226, "points" : [ { "x" : 790, "y" : 711 } ] } ] }, { "id" : 98358, "reactomeId" : 10598066, "displayName" : "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1791, "y" : 505 }, "minX" : 1780, "maxX" : 1797, "minY" : 458, "maxY" : 554, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1781, "y" : 554 }, "to" : { "x" : 1791, "y" : 505 } }, { "from" : { "x" : 1791, "y" : 505 }, "to" : { "x" : 1780, "y" : 458 } } ], "reactionShape" : { "a" : { "x" : 1785, "y" : 499 }, "b" : { "x" : 1797, "y" : 511 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1791, "y" : 505 } }, "inputs" : [ { "id" : 98339, "points" : [ { "x" : 1793, "y" : 606 } ] }, { "id" : 98359, "points" : [ { "x" : 1752, "y" : 578 } ] } ], "outputs" : [ { "id" : 98360, "points" : [ { "x" : 1763, "y" : 443 } ] }, { "id" : 98342, "points" : [ { "x" : 1780, "y" : 411 } ] } ], "catalysts" : [ { "id" : 98361, "points" : [ { "x" : 1756, "y" : 523 } ] } ] }, { "id" : 98230, "reactomeId" : 10597875, "displayName" : "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 795, "y" : 921 }, "minX" : 789, "maxX" : 801, "minY" : 865, "maxY" : 951, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 795, "y" : 865 }, "to" : { "x" : 795, "y" : 921 } }, { "from" : { "x" : 795, "y" : 921 }, "to" : { "x" : 796, "y" : 951 } } ], "reactionShape" : { "a" : { "x" : 789, "y" : 915 }, "b" : { "x" : 801, "y" : 927 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 795, "y" : 921 } }, "inputs" : [ { "id" : 98223, "points" : [ { "x" : 829, "y" : 835 } ] }, { "id" : 98231, "points" : [ { "x" : 774, "y" : 856 } ] } ], "outputs" : [ { "id" : 98232, "points" : [ { "x" : 826, "y" : 981 } ] }, { "id" : 98233, "points" : [ { "x" : 768, "y" : 979 } ] } ], "catalysts" : [ { "id" : 98234, "points" : [ { "x" : 754, "y" : 915 } ] } ] }, { "id" : 98235, "reactomeId" : 10597923, "displayName" : "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 875, "y" : 903 }, "minX" : 869, "maxX" : 881, "minY" : 869, "maxY" : 951, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 878, "y" : 951 }, "to" : { "x" : 875, "y" : 903 } }, { "from" : { "x" : 875, "y" : 903 }, "to" : { "x" : 875, "y" : 869 } } ], "reactionShape" : { "a" : { "x" : 869, "y" : 897 }, "b" : { "x" : 881, "y" : 909 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 875, "y" : 903 } }, "inputs" : [ { "id" : 98232, "points" : [ { "x" : 851, "y" : 981 } ] }, { "id" : 98236, "points" : [ { "x" : 914, "y" : 984 } ] } ], "outputs" : [ { "id" : 98223, "points" : [ { "x" : 853, "y" : 835 } ] }, { "id" : 98237, "points" : [ { "x" : 954, "y" : 863 } ] }, { "id" : 98238, "points" : [ { "x" : 908, "y" : 849 } ] } ], "catalysts" : [ { "id" : 98234, "points" : [ { "x" : 754, "y" : 908 } ] } ] }, { "id" : 98362, "reactomeId" : 10598035, "displayName" : "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1950, "y" : 585 }, "minX" : 1905, "maxX" : 1985, "minY" : 579, "maxY" : 591, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1905, "y" : 585 }, "to" : { "x" : 1950, "y" : 585 } }, { "from" : { "x" : 1950, "y" : 585 }, "to" : { "x" : 1985, "y" : 586 } } ], "reactionShape" : { "a" : { "x" : 1944, "y" : 579 }, "b" : { "x" : 1956, "y" : 591 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1950, "y" : 585 } }, "inputs" : [ { "id" : 98363, "points" : [ { "x" : 1902, "y" : 546 } ] }, { "id" : 98339, "points" : [ { "x" : 1838, "y" : 606 } ] } ], "outputs" : [ { "id" : 98364, "points" : [ { "x" : 2001, "y" : 601 } ] }, { "id" : 98365, "points" : [ { "x" : 2001, "y" : 574 } ] } ], "catalysts" : [ { "id" : 98366, "points" : [ { "x" : 1974, "y" : 534 } ] } ] }, { "id" : 98367, "reactomeId" : 10597881, "displayName" : "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1918, "y" : 605 }, "minX" : 1898, "maxX" : 1946, "minY" : 599, "maxY" : 611, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1946, "y" : 605 }, "to" : { "x" : 1918, "y" : 605 } }, { "from" : { "x" : 1918, "y" : 605 }, "to" : { "x" : 1898, "y" : 605 } } ], "reactionShape" : { "a" : { "x" : 1912, "y" : 599 }, "b" : { "x" : 1924, "y" : 611 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1918, "y" : 605 } }, "inputs" : [ { "id" : 98364, "points" : [ { "x" : 1970, "y" : 610 } ] }, { "id" : 98368, "points" : [ { "x" : 1944, "y" : 631 } ] } ], "outputs" : [ { "id" : 98369, "points" : [ { "x" : 1876, "y" : 631 } ] }, { "id" : 98339, "points" : [ { "x" : 1850, "y" : 614 } ] } ], "catalysts" : [ { "id" : 98366, "points" : [ { "x" : 1971, "y" : 534 } ] } ] }, { "id" : 98239, "reactomeId" : 10597968, "displayName" : "I(1,4,5)P3 transports from the cytosol to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1059, "y" : 167 }, "minX" : 720, "maxX" : 1094, "minY" : 161, "maxY" : 195, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 720, "y" : 195 }, "to" : { "x" : 1059, "y" : 167 } }, { "from" : { "x" : 1059, "y" : 167 }, "to" : { "x" : 1094, "y" : 168 } } ], "endShape" : { "a" : { "x" : 1087, "y" : 172 }, "b" : { "x" : 1094, "y" : 168 }, "c" : { "x" : 1087, "y" : 164 }, "type" : "ARROW", "centre" : { "x" : 1087, "y" : 164 } }, "reactionShape" : { "a" : { "x" : 1053, "y" : 161 }, "b" : { "x" : 1065, "y" : 173 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1059, "y" : 167 } }, "inputs" : [ { "id" : 98153 } ], "outputs" : [ { "id" : 98240 } ], "catalysts" : [ { "id" : 98241, "points" : [ { "x" : 1058, "y" : 275 } ] } ] }, { "id" : 98242, "reactomeId" : 10597920, "displayName" : "I(1,3,4,5)P4 transports from the cytosol to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1060, "y" : 440 }, "minX" : 890, "maxX" : 1088, "minY" : 434, "maxY" : 467, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 890, "y" : 467 }, "to" : { "x" : 1060, "y" : 440 } }, { "from" : { "x" : 1060, "y" : 440 }, "to" : { "x" : 1088, "y" : 440 } } ], "endShape" : { "a" : { "x" : 1081, "y" : 444 }, "b" : { "x" : 1088, "y" : 440 }, "c" : { "x" : 1081, "y" : 436 }, "type" : "ARROW", "centre" : { "x" : 1081, "y" : 436 } }, "reactionShape" : { "a" : { "x" : 1054, "y" : 434 }, "b" : { "x" : 1066, "y" : 446 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1060, "y" : 440 } }, "inputs" : [ { "id" : 98210 } ], "outputs" : [ { "id" : 98243 } ], "catalysts" : [ { "id" : 98241, "points" : [ { "x" : 1058, "y" : 340 } ] } ] }, { "id" : 98370, "reactomeId" : 10597888, "displayName" : "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2302, "y" : 696 }, "minX" : 2296, "maxX" : 2308, "minY" : 635, "maxY" : 738, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2303, "y" : 635 }, "to" : { "x" : 2302, "y" : 696 } }, { "from" : { "x" : 2302, "y" : 696 }, "to" : { "x" : 2302, "y" : 738 } } ], "reactionShape" : { "a" : { "x" : 2296, "y" : 690 }, "b" : { "x" : 2308, "y" : 702 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2302, "y" : 696 } }, "inputs" : [ { "id" : 98371, "points" : [ { "x" : 2283, "y" : 609 } ] }, { "id" : 98372, "points" : [ { "x" : 2334, "y" : 611 } ] } ], "outputs" : [ { "id" : 98373, "points" : [ { "x" : 2318, "y" : 774 } ] }, { "id" : 98374, "points" : [ { "x" : 2279, "y" : 757 } ] } ], "catalysts" : [ { "id" : 98375, "points" : [ { "x" : 2276, "y" : 695 } ] } ] }, { "id" : 98244, "reactomeId" : 10597985, "displayName" : "I(1,3,4,6)P4 transports from the cytosol to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1061, "y" : 783 }, "minX" : 892, "maxX" : 1093, "minY" : 777, "maxY" : 810, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 892, "y" : 810 }, "to" : { "x" : 1061, "y" : 783 } }, { "from" : { "x" : 1061, "y" : 783 }, "to" : { "x" : 1093, "y" : 783 } } ], "endShape" : { "a" : { "x" : 1086, "y" : 787 }, "b" : { "x" : 1093, "y" : 783 }, "c" : { "x" : 1086, "y" : 779 }, "type" : "ARROW", "centre" : { "x" : 1086, "y" : 779 } }, "reactionShape" : { "a" : { "x" : 1055, "y" : 777 }, "b" : { "x" : 1067, "y" : 789 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1061, "y" : 783 } }, "inputs" : [ { "id" : 98223 } ], "outputs" : [ { "id" : 98245 } ], "catalysts" : [ { "id" : 98246, "points" : [ { "x" : 1059, "y" : 749 } ] } ] }, { "id" : 98247, "reactomeId" : 10597964, "displayName" : "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1258, "y" : 652 }, "minX" : 1209, "maxX" : 1291, "minY" : 646, "maxY" : 658, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1209, "y" : 651 }, "to" : { "x" : 1258, "y" : 652 } }, { "from" : { "x" : 1258, "y" : 652 }, "to" : { "x" : 1291, "y" : 651 } } ], "reactionShape" : { "a" : { "x" : 1252, "y" : 646 }, "b" : { "x" : 1264, "y" : 658 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1258, "y" : 652 } }, "inputs" : [ { "id" : 98248, "points" : [ { "x" : 1172, "y" : 638 } ] }, { "id" : 98249, "points" : [ { "x" : 1188, "y" : 693 } ] } ], "outputs" : [ { "id" : 98250, "points" : [ { "x" : 1336, "y" : 636 } ] }, { "id" : 98251, "points" : [ { "x" : 1314, "y" : 679 } ] }, { "id" : 98252, "points" : [ { "x" : 1287, "y" : 618 } ] } ], "catalysts" : [ { "id" : 98253, "points" : [ { "x" : 1258, "y" : 686 } ] } ] }, { "id" : 98376, "reactomeId" : 10598072, "displayName" : "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2164, "y" : 720 }, "minX" : 2158, "maxX" : 2170, "minY" : 683, "maxY" : 750, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2163, "y" : 750 }, "to" : { "x" : 2164, "y" : 720 } }, { "from" : { "x" : 2164, "y" : 720 }, "to" : { "x" : 2165, "y" : 683 } } ], "reactionShape" : { "a" : { "x" : 2158, "y" : 714 }, "b" : { "x" : 2170, "y" : 726 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2164, "y" : 720 } }, "inputs" : [ { "id" : 98377, "points" : [ { "x" : 2163, "y" : 776 } ] }, { "id" : 98378, "points" : [ { "x" : 2183, "y" : 759 } ] } ], "outputs" : [ { "id" : 98379, "points" : [ { "x" : 2185, "y" : 655 } ] }, { "id" : 98380, "points" : [ { "x" : 2141, "y" : 667 } ] } ], "catalysts" : [ { "id" : 98375, "points" : [ { "x" : 2217, "y" : 703 } ] } ] }, { "id" : 98381, "reactomeId" : 10616544, "displayName" : "MIOX oxidises Ins to GlcA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 129, "y" : 740 }, "minX" : 123, "maxX" : 135, "minY" : 703, "maxY" : 771, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 129, "y" : 703 }, "to" : { "x" : 129, "y" : 740 } }, { "from" : { "x" : 129, "y" : 740 }, "to" : { "x" : 129, "y" : 771 } } ], "reactionShape" : { "a" : { "x" : 123, "y" : 734 }, "b" : { "x" : 135, "y" : 746 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 129, "y" : 740 } }, "inputs" : [ { "id" : 98174, "points" : [ { "x" : 168, "y" : 385 } ] }, { "id" : 98382, "points" : [ { "x" : 100, "y" : 677 } ] } ], "outputs" : [ { "id" : 98383, "points" : [ { "x" : 129, "y" : 825 } ] }, { "id" : 98384, "points" : [ { "x" : 158, "y" : 787 } ] }, { "id" : 98385, "points" : [ { "x" : 197, "y" : 759 } ] } ], "catalysts" : [ { "id" : 98386, "points" : [ { "x" : 101, "y" : 740 } ] } ] }, { "id" : 98254, "reactomeId" : 10598087, "displayName" : "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1150, "y" : 299 }, "minX" : 1144, "maxX" : 1156, "minY" : 220, "maxY" : 360, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1150, "y" : 220 }, "to" : { "x" : 1150, "y" : 299 } }, { "from" : { "x" : 1150, "y" : 299 }, "to" : { "x" : 1150, "y" : 360 } } ], "reactionShape" : { "a" : { "x" : 1144, "y" : 293 }, "b" : { "x" : 1156, "y" : 305 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1150, "y" : 299 } }, "inputs" : [ { "id" : 98240, "points" : [ { "x" : 1138, "y" : 188 } ] }, { "id" : 98255, "points" : [ { "x" : 1190, "y" : 188 } ] } ], "outputs" : [ { "id" : 98243, "points" : [ { "x" : 1137, "y" : 422 } ] }, { "id" : 98256, "points" : [ { "x" : 1121, "y" : 379 } ] }, { "id" : 98257, "points" : [ { "x" : 1196, "y" : 421 } ] } ], "catalysts" : [ { "id" : 98258, "points" : [ { "x" : 1194, "y" : 298 } ] } ] }, { "id" : 98259, "reactomeId" : 10597998, "displayName" : "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1235, "y" : 525 }, "minX" : 1192, "maxX" : 1269, "minY" : 500, "maxY" : 548, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1192, "y" : 500 }, "to" : { "x" : 1235, "y" : 525 } }, { "from" : { "x" : 1235, "y" : 525 }, "to" : { "x" : 1269, "y" : 548 } } ], "reactionShape" : { "a" : { "x" : 1229, "y" : 519 }, "b" : { "x" : 1241, "y" : 531 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1235, "y" : 525 } }, "inputs" : [ { "id" : 98260, "points" : [ { "x" : 1118, "y" : 494 } ] }, { "id" : 98243, "points" : [ { "x" : 1148, "y" : 458 } ] } ], "outputs" : [ { "id" : 98261, "points" : [ { "x" : 1229, "y" : 561 } ] }, { "id" : 98250, "points" : [ { "x" : 1351, "y" : 600 } ] } ], "catalysts" : [ { "id" : 98262, "points" : [ { "x" : 1245, "y" : 501 } ] } ] }, { "id" : 98263, "reactomeId" : 10598078, "displayName" : "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1260, "y" : 749 }, "minX" : 1227, "maxX" : 1351, "minY" : 743, "maxY" : 755, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1227, "y" : 749 }, "to" : { "x" : 1260, "y" : 749 } }, { "from" : { "x" : 1260, "y" : 749 }, "to" : { "x" : 1351, "y" : 748 } } ], "reactionShape" : { "a" : { "x" : 1254, "y" : 743 }, "b" : { "x" : 1266, "y" : 755 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1260, "y" : 749 } }, "inputs" : [ { "id" : 98245, "points" : [ { "x" : 1177, "y" : 765 } ] }, { "id" : 98249, "points" : [ { "x" : 1199, "y" : 729 } ] } ], "outputs" : [ { "id" : 98250, "points" : [ { "x" : 1371, "y" : 636 } ] }, { "id" : 98264, "points" : [ { "x" : 1388, "y" : 746 } ] }, { "id" : 98251, "points" : [ { "x" : 1333, "y" : 715 } ] } ], "catalysts" : [ { "id" : 98253, "points" : [ { "x" : 1258, "y" : 714 } ] } ] }, { "id" : 98265, "reactomeId" : 10597941, "displayName" : "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1506, "y" : 649 }, "minX" : 1463, "maxX" : 1567, "minY" : 639, "maxY" : 669, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1463, "y" : 639 }, "to" : { "x" : 1506, "y" : 649 } }, { "from" : { "x" : 1506, "y" : 649 }, "to" : { "x" : 1567, "y" : 669 } } ], "reactionShape" : { "a" : { "x" : 1500, "y" : 643 }, "b" : { "x" : 1512, "y" : 655 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1506, "y" : 649 } }, "inputs" : [ { "id" : 98266, "points" : [ { "x" : 1441, "y" : 654 } ] }, { "id" : 98250, "points" : [ { "x" : 1427, "y" : 629 } ] } ], "outputs" : [ { "id" : 98267, "points" : [ { "x" : 1593, "y" : 765 } ] }, { "id" : 98268, "points" : [ { "x" : 1614, "y" : 700 } ] }, { "id" : 98269, "points" : [ { "x" : 1624, "y" : 670 } ] } ], "catalysts" : [ { "id" : 98270, "points" : [ { "x" : 1505, "y" : 683 } ] } ] }, { "id" : 98271, "reactomeId" : 10597957, "displayName" : "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1512, "y" : 564 }, "minX" : 1433, "maxX" : 1570, "minY" : 558, "maxY" : 570, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1433, "y" : 565 }, "to" : { "x" : 1512, "y" : 564 } }, { "from" : { "x" : 1512, "y" : 564 }, "to" : { "x" : 1570, "y" : 564 } } ], "reactionShape" : { "a" : { "x" : 1506, "y" : 558 }, "b" : { "x" : 1518, "y" : 570 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1512, "y" : 564 } }, "inputs" : [ { "id" : 98272, "points" : [ { "x" : 1413, "y" : 547 } ] }, { "id" : 98250, "points" : [ { "x" : 1390, "y" : 600 } ] } ], "outputs" : [ { "id" : 98273, "points" : [ { "x" : 1593, "y" : 570 } ] }, { "id" : 98274, "points" : [ { "x" : 1570, "y" : 411 } ] } ], "catalysts" : [ { "id" : 98275, "points" : [ { "x" : 1487, "y" : 391 } ] } ] }, { "id" : 98149, "reactomeId" : 10598056, "displayName" : "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 564, "y" : 67 }, "minX" : 524, "maxX" : 599, "minY" : 61, "maxY" : 73, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 524, "y" : 67 }, "to" : { "x" : 564, "y" : 67 } }, { "from" : { "x" : 564, "y" : 67 }, "to" : { "x" : 599, "y" : 68 } } ], "reactionShape" : { "a" : { "x" : 558, "y" : 61 }, "b" : { "x" : 570, "y" : 73 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 564, "y" : 67 } }, "inputs" : [ { "id" : 98150, "points" : [ { "x" : 494, "y" : 37 } ] }, { "id" : 98151, "points" : [ { "x" : 506, "y" : 97 } ] } ], "outputs" : [ { "id" : 98152, "points" : [ { "x" : 630, "y" : 39 } ] }, { "id" : 98153, "points" : [ { "x" : 671, "y" : 180 } ] }, { "id" : 98154, "points" : [ { "x" : 639, "y" : 75 } ] } ], "catalysts" : [ { "id" : 98155, "points" : [ { "x" : 563, "y" : 31 } ] } ] }, { "id" : 98276, "reactomeId" : 10598081, "displayName" : "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1600, "y" : 327 }, "minX" : 1594, "maxX" : 1606, "minY" : 291, "maxY" : 353, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1599, "y" : 353 }, "to" : { "x" : 1600, "y" : 327 } }, { "from" : { "x" : 1600, "y" : 327 }, "to" : { "x" : 1600, "y" : 291 } } ], "reactionShape" : { "a" : { "x" : 1594, "y" : 321 }, "b" : { "x" : 1606, "y" : 333 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1600, "y" : 327 } }, "inputs" : [ { "id" : 98277, "points" : [ { "x" : 1631, "y" : 360 } ] }, { "id" : 98274, "points" : [ { "x" : 1580, "y" : 375 } ] } ], "outputs" : [ { "id" : 98278, "points" : [ { "x" : 1559, "y" : 260 } ] }, { "id" : 98279, "points" : [ { "x" : 1630, "y" : 270 } ] } ], "catalysts" : [ { "id" : 98275, "points" : [ { "x" : 1512, "y" : 357 } ] } ] }, { "id" : 98280, "reactomeId" : 10598001, "displayName" : "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1572, "y" : 846 }, "minX" : 1566, "maxX" : 1578, "minY" : 822, "maxY" : 885, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1572, "y" : 822 }, "to" : { "x" : 1572, "y" : 846 } }, { "from" : { "x" : 1572, "y" : 846 }, "to" : { "x" : 1572, "y" : 885 } } ], "reactionShape" : { "a" : { "x" : 1566, "y" : 840 }, "b" : { "x" : 1578, "y" : 852 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1572, "y" : 846 } }, "inputs" : [ { "id" : 98267, "points" : [ { "x" : 1587, "y" : 801 } ] }, { "id" : 98281, "points" : [ { "x" : 1554, "y" : 815 } ] } ], "outputs" : [ { "id" : 98282, "points" : [ { "x" : 1591, "y" : 907 } ] }, { "id" : 98283, "points" : [ { "x" : 1550, "y" : 898 } ] } ], "catalysts" : [ { "id" : 98284, "points" : [ { "x" : 1505, "y" : 870 } ] } ] }, { "id" : 98285, "reactomeId" : 10598069, "displayName" : "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1492, "y" : 953 }, "minX" : 1462, "maxX" : 1529, "minY" : 947, "maxY" : 959, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1529, "y" : 954 }, "to" : { "x" : 1492, "y" : 953 } }, { "from" : { "x" : 1492, "y" : 953 }, "to" : { "x" : 1462, "y" : 953 } } ], "reactionShape" : { "a" : { "x" : 1486, "y" : 947 }, "b" : { "x" : 1498, "y" : 959 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1492, "y" : 953 } }, "inputs" : [ { "id" : 98282, "points" : [ { "x" : 1565, "y" : 938 } ] }, { "id" : 98286, "points" : [ { "x" : 1572, "y" : 981 } ] } ], "outputs" : [ { "id" : 98287, "points" : [ { "x" : 1423, "y" : 938 } ] }, { "id" : 98288, "points" : [ { "x" : 1435, "y" : 975 } ] } ], "catalysts" : [ { "id" : 98284, "points" : [ { "x" : 1473, "y" : 897 } ] } ] }, { "id" : 98156, "reactomeId" : 10597946, "displayName" : "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 563, "y" : 86 }, "minX" : 503, "maxX" : 601, "minY" : 79, "maxY" : 92, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 503, "y" : 79 }, "to" : { "x" : 563, "y" : 86 } }, { "from" : { "x" : 563, "y" : 86 }, "to" : { "x" : 601, "y" : 87 } } ], "reactionShape" : { "a" : { "x" : 557, "y" : 80 }, "b" : { "x" : 569, "y" : 92 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 563, "y" : 86 } }, "inputs" : [ { "id" : 98150, "points" : [ { "x" : 486, "y" : 37 } ] }, { "id" : 98151, "points" : [ { "x" : 500, "y" : 97 } ] } ], "outputs" : [ { "id" : 98152, "points" : [ { "x" : 634, "y" : 39 } ] }, { "id" : 98153, "points" : [ { "x" : 670, "y" : 180 } ] }, { "id" : 98154, "points" : [ { "x" : 639, "y" : 81 } ] } ], "catalysts" : [ { "id" : 98157, "points" : [ { "x" : 563, "y" : 119 } ] } ] }, { "id" : 98158, "reactomeId" : 10598027, "displayName" : "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 570, "y" : 254 }, "minX" : 529, "maxX" : 599, "minY" : 248, "maxY" : 260, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 529, "y" : 254 }, "to" : { "x" : 570, "y" : 254 } }, { "from" : { "x" : 570, "y" : 254 }, "to" : { "x" : 599, "y" : 253 } } ], "reactionShape" : { "a" : { "x" : 564, "y" : 248 }, "b" : { "x" : 576, "y" : 260 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 570, "y" : 254 } }, "inputs" : [ { "id" : 98159, "points" : [ { "x" : 494, "y" : 292 } ] }, { "id" : 98160, "points" : [ { "x" : 483, "y" : 254 } ] } ], "outputs" : [ { "id" : 98161, "points" : [ { "x" : 627, "y" : 292 } ] }, { "id" : 98153, "points" : [ { "x" : 658, "y" : 216 } ] }, { "id" : 98162, "points" : [ { "x" : 627, "y" : 256 } ] } ], "catalysts" : [ { "id" : 98163, "points" : [ { "x" : 496, "y" : 356 } ] } ] }, { "id" : 98289, "reactomeId" : 10597966, "displayName" : "IP6 transports from the cytosol to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1697, "y" : 784 }, "minX" : 1618, "maxX" : 1770, "minY" : 778, "maxY" : 790, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1770, "y" : 785 }, "to" : { "x" : 1697, "y" : 784 } }, { "from" : { "x" : 1697, "y" : 784 }, "to" : { "x" : 1618, "y" : 783 } } ], "endShape" : { "a" : { "x" : 1625, "y" : 779 }, "b" : { "x" : 1618, "y" : 783 }, "c" : { "x" : 1625, "y" : 787 }, "type" : "ARROW", "centre" : { "x" : 1625, "y" : 787 } }, "reactionShape" : { "a" : { "x" : 1691, "y" : 778 }, "b" : { "x" : 1703, "y" : 790 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1697, "y" : 784 } }, "inputs" : [ { "id" : 98290 } ], "outputs" : [ { "id" : 98267 } ], "catalysts" : [ { "id" : 98291, "points" : [ { "x" : 1685, "y" : 825 } ] } ] }, { "id" : 98292, "reactomeId" : 10597990, "displayName" : "5-PP-IP5 transports from the nucleus to the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1699, "y" : 923 }, "minX" : 1642, "maxX" : 1771, "minY" : 917, "maxY" : 929, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1642, "y" : 924 }, "to" : { "x" : 1699, "y" : 923 } }, { "from" : { "x" : 1699, "y" : 923 }, "to" : { "x" : 1771, "y" : 923 } } ], "endShape" : { "a" : { "x" : 1764, "y" : 927 }, "b" : { "x" : 1771, "y" : 923 }, "c" : { "x" : 1764, "y" : 919 }, "type" : "ARROW", "centre" : { "x" : 1764, "y" : 919 } }, "reactionShape" : { "a" : { "x" : 1693, "y" : 917 }, "b" : { "x" : 1705, "y" : 929 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1699, "y" : 923 } }, "inputs" : [ { "id" : 98282 } ], "outputs" : [ { "id" : 98293 } ], "catalysts" : [ { "id" : 98291, "points" : [ { "x" : 1686, "y" : 890 } ] } ] }, { "id" : 98164, "reactomeId" : 10597983, "displayName" : "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 642, "y" : 400 }, "minX" : 636, "maxX" : 648, "minY" : 372, "maxY" : 427, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 641, "y" : 427 }, "to" : { "x" : 642, "y" : 400 } }, { "from" : { "x" : 642, "y" : 400 }, "to" : { "x" : 641, "y" : 372 } } ], "reactionShape" : { "a" : { "x" : 636, "y" : 394 }, "b" : { "x" : 648, "y" : 406 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 642, "y" : 400 } }, "inputs" : [ { "id" : 98165, "points" : [ { "x" : 559, "y" : 458 } ] }, { "id" : 98166, "points" : [ { "x" : 641, "y" : 453 } ] } ], "outputs" : [ { "id" : 98167, "points" : [ { "x" : 658, "y" : 363 } ] }, { "id" : 98168, "points" : [ { "x" : 617, "y" : 362 } ] } ], "catalysts" : [ { "id" : 98169, "points" : [ { "x" : 669, "y" : 392 } ] } ] }, { "id" : 98294, "reactomeId" : 10597974, "displayName" : "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1939, "y" : 1161 }, "minX" : 1933, "maxX" : 1945, "minY" : 1135, "maxY" : 1186, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1940, "y" : 1186 }, "to" : { "x" : 1939, "y" : 1161 } }, { "from" : { "x" : 1939, "y" : 1161 }, "to" : { "x" : 1940, "y" : 1135 } } ], "reactionShape" : { "a" : { "x" : 1933, "y" : 1155 }, "b" : { "x" : 1945, "y" : 1167 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1939, "y" : 1161 } }, "inputs" : [ { "id" : 98295, "points" : [ { "x" : 1950, "y" : 1236 } ] }, { "id" : 98296, "points" : [ { "x" : 1913, "y" : 1203 } ] } ], "outputs" : [ { "id" : 98297, "points" : [ { "x" : 1939, "y" : 1117 } ] }, { "id" : 98298, "points" : [ { "x" : 1972, "y" : 1135 } ] } ], "catalysts" : [ { "id" : 98299, "points" : [ { "x" : 1908, "y" : 1159 } ] } ] }, { "id" : 98170, "reactomeId" : 10598016, "displayName" : "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 121, "y" : 293 }, "minX" : 115, "maxX" : 148, "minY" : 243, "maxY" : 336, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 148, "y" : 243 }, "to" : { "x" : 121, "y" : 293 } }, { "from" : { "x" : 121, "y" : 293 }, "to" : { "x" : 121, "y" : 336 } } ], "reactionShape" : { "a" : { "x" : 115, "y" : 287 }, "b" : { "x" : 127, "y" : 299 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 121, "y" : 293 } }, "inputs" : [ { "id" : 98171, "points" : [ { "x" : 161, "y" : 226 } ] }, { "id" : 98172, "points" : [ { "x" : 168, "y" : 249 } ] } ], "outputs" : [ { "id" : 98173, "points" : [ { "x" : 85, "y" : 358 } ] }, { "id" : 98174, "points" : [ { "x" : 148, "y" : 354 } ] } ], "catalysts" : [ { "id" : 98175, "points" : [ { "x" : 230, "y" : 291 } ] } ] }, { "id" : 98300, "reactomeId" : 10597915, "displayName" : "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1738, "y" : 1002 }, "minX" : 1732, "maxX" : 1744, "minY" : 965, "maxY" : 1043, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1739, "y" : 1043 }, "to" : { "x" : 1738, "y" : 1002 } }, { "from" : { "x" : 1738, "y" : 1002 }, "to" : { "x" : 1738, "y" : 965 } } ], "reactionShape" : { "a" : { "x" : 1732, "y" : 996 }, "b" : { "x" : 1744, "y" : 1008 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1738, "y" : 1002 } }, "inputs" : [ { "id" : 98301, "points" : [ { "x" : 1800, "y" : 1079 } ] }, { "id" : 98302, "points" : [ { "x" : 1766, "y" : 1047 } ] } ], "outputs" : [ { "id" : 98293, "points" : [ { "x" : 1783, "y" : 941 } ] }, { "id" : 98303, "points" : [ { "x" : 1775, "y" : 962 } ] } ], "catalysts" : [ { "id" : 98304, "points" : [ { "x" : 1759, "y" : 1004 } ] } ] } ], "compartments" : [ { "id" : 98387, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1216, "y" : 735 }, "minX" : 0, "maxX" : 2433, "minY" : 13, "maxY" : 1457, "prop" : { "x" : 0, "y" : 13, "width" : 2433, "height" : 1444 }, "textPosition" : { "x" : 42, "y" : 533 }, "insets" : { "x" : 10, "y" : 23, "width" : 2413, "height" : 1424 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 98388, 98149, 98150, 98151, 98153, 98155, 98156, 98157, 98158, 98170, 98171, 98172, 98173, 98174, 98175, 98160, 98176, 98177, 98179, 98178, 98180, 98182, 98181, 98183, 98184, 98186, 98185, 98187, 98190, 98191, 98192, 98193, 98194, 98195, 98197, 98199, 98200, 98389, 98203, 98205, 98206, 98207, 98210, 98209, 98212, 98211, 98208, 98213, 98214, 98216, 98215, 98217, 98226, 98222, 98218, 98225, 98223, 98227, 98228, 98229, 98221, 98230, 98231, 98232, 98233, 98234, 98235, 98236, 98238, 98290, 98293, 98331, 98301, 98298, 98294, 98307, 98299, 98300, 98309, 98303, 98306, 98292, 98305, 98308, 98302, 98310, 98322, 98323, 98325, 98324, 98326, 98327, 98328, 98329, 98330, 98332, 98333, 98335, 98334, 98336, 98337, 98339, 98355, 98343, 98348, 98349, 98350, 98351, 98352, 98353, 98354, 98357, 98356, 98358, 98359, 98361, 98362, 98363, 98364, 98365, 98366, 98367, 98369, 98368, 98393, 98394, 98402, 98403, 98188, 98342, 98404, 98360, 98344, 98407, 98345, 98347, 98346, 98295, 98408, 98297, 98409, 98296, 98381, 98382, 98383, 98384, 98385, 98386, 98189, 98196, 98201, 98198, 98202, 98204, 98152, 98400, 98410, 98304, 98154, 98162, 98219, 98220, 98224, 98237 ] }, { "id" : 98389, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1377, "y" : 714 }, "minX" : 1057, "maxX" : 1698, "minY" : 127, "maxY" : 1301, "prop" : { "x" : 1057, "y" : 127, "width" : 641, "height" : 1174 }, "textPosition" : { "x" : 1065, "y" : 1261 }, "insets" : { "x" : 1067, "y" : 137, "width" : 621, "height" : 1154 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 98240, 98243, 98245, 98247, 98248, 98251, 98250, 98253, 98254, 98255, 98257, 98258, 98259, 98260, 98262, 98263, 98249, 98265, 98266, 98267, 98269, 98270, 98271, 98272, 98275, 98276, 98280, 98281, 98282, 98283, 98284, 98285, 98286, 98287, 98288, 98311, 98314, 98315, 98321, 98338, 98274, 98273, 98341, 98277, 98278, 98279, 98289, 98316, 98405, 98318, 98320, 98406, 98319, 98313, 98239, 98242, 98244, 98256, 98252, 98268, 98264, 98317, 98261, 98241, 98246, 98291, 98312, 98340 ] }, { "id" : 98388, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 593, "y" : 404 }, "minX" : 445, "maxX" : 741, "minY" : 309, "maxY" : 499, "prop" : { "x" : 445, "y" : 309, "width" : 296, "height" : 190 }, "textPosition" : { "x" : 453, "y" : 403 }, "insets" : { "x" : 455, "y" : 319, "width" : 276, "height" : 170 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 98159, 98161, 98164, 98167, 98169, 98166, 98168, 98165, 98163 ] }, { "id" : 98393, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2239, "y" : 682 }, "minX" : 2077, "maxX" : 2402, "minY" : 526, "maxY" : 838, "prop" : { "x" : 2077, "y" : 526, "width" : 325, "height" : 312 }, "textPosition" : { "x" : 2084, "y" : 535 }, "insets" : { "x" : 2087, "y" : 536, "width" : 305, "height" : 292 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 98371, 98373, 98370, 98375, 98374, 98372, 98377, 98378, 98380, 98376, 98379 ] } ], "notes" : [ ], "links" : [ { "id" : 98403, "renderableClass" : "Interaction", "position" : { "x" : 734, "y" : 158 }, "minX" : 701, "maxX" : 767, "minY" : 136, "maxY" : 180, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 701, "y" : 180 }, "to" : { "x" : 767, "y" : 136 } } ], "endShape" : { "a" : { "x" : 763, "y" : 143 }, "b" : { "x" : 767, "y" : 136 }, "c" : { "x" : 759, "y" : 137 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 759, "y" : 137 } }, "reactionShape" : { "a" : { "x" : 728, "y" : 152 }, "b" : { "x" : 740, "y" : 164 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 734, "y" : 158 } }, "inputs" : [ { "id" : 98153 } ], "outputs" : [ { "id" : 98394 } ] }, { "id" : 98405, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1566, "y" : 1252 }, "minX" : 1554, "maxX" : 1579, "minY" : 1246, "maxY" : 1258, "segments" : [ { "from" : { "x" : 1554, "y" : 1252 }, "to" : { "x" : 1579, "y" : 1252 } } ], "reactionShape" : { "a" : { "x" : 1560, "y" : 1246 }, "b" : { "x" : 1572, "y" : 1258 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1566, "y" : 1252 } }, "inputs" : [ { "id" : 98316 } ], "outputs" : [ { "id" : 98311 } ] }, { "id" : 98404, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1806, "y" : 415 }, "minX" : 1799, "maxX" : 1813, "minY" : 409, "maxY" : 421, "segments" : [ { "from" : { "x" : 1799, "y" : 411 }, "to" : { "x" : 1813, "y" : 419 } } ], "reactionShape" : { "a" : { "x" : 1800, "y" : 409 }, "b" : { "x" : 1812, "y" : 421 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1806, "y" : 415 } }, "inputs" : [ { "id" : 98342 } ], "outputs" : [ { "id" : 98355 } ] }, { "id" : 98407, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1845, "y" : 390 }, "minX" : 1839, "maxX" : 1851, "minY" : 370, "maxY" : 411, "segments" : [ { "from" : { "x" : 1845, "y" : 370 }, "to" : { "x" : 1846, "y" : 411 } } ], "reactionShape" : { "a" : { "x" : 1839, "y" : 384 }, "b" : { "x" : 1851, "y" : 396 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1845, "y" : 390 } }, "inputs" : [ { "id" : 98344 } ], "outputs" : [ { "id" : 98355 } ] }, { "id" : 98406, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1577, "y" : 1098 }, "minX" : 1570, "maxX" : 1584, "minY" : 1092, "maxY" : 1104, "segments" : [ { "from" : { "x" : 1570, "y" : 1098 }, "to" : { "x" : 1584, "y" : 1098 } } ], "reactionShape" : { "a" : { "x" : 1571, "y" : 1092 }, "b" : { "x" : 1583, "y" : 1104 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1577, "y" : 1098 } }, "inputs" : [ { "id" : 98320 } ], "outputs" : [ { "id" : 98314 } ] }, { "id" : 98409, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1875, "y" : 1098 }, "minX" : 1865, "maxX" : 1886, "minY" : 1092, "maxY" : 1104, "segments" : [ { "from" : { "x" : 1886, "y" : 1098 }, "to" : { "x" : 1865, "y" : 1098 } } ], "reactionShape" : { "a" : { "x" : 1869, "y" : 1092 }, "b" : { "x" : 1881, "y" : 1104 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1875, "y" : 1098 } }, "inputs" : [ { "id" : 98297 } ], "outputs" : [ { "id" : 98301 } ] }, { "id" : 98408, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1903, "y" : 1252 }, "minX" : 1890, "maxX" : 1917, "minY" : 1246, "maxY" : 1258, "segments" : [ { "from" : { "x" : 1917, "y" : 1252 }, "to" : { "x" : 1890, "y" : 1252 } } ], "reactionShape" : { "a" : { "x" : 1897, "y" : 1246 }, "b" : { "x" : 1909, "y" : 1258 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1903, "y" : 1252 } }, "inputs" : [ { "id" : 98295 } ], "outputs" : [ { "id" : 98307 } ] }, { "id" : 98410, "renderableClass" : "Interaction", "position" : { "x" : 130, "y" : 893 }, "minX" : 124, "maxX" : 136, "minY" : 861, "maxY" : 926, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 130, "y" : 861 }, "to" : { "x" : 130, "y" : 926 } } ], "endShape" : { "a" : { "x" : 126, "y" : 919 }, "b" : { "x" : 130, "y" : 926 }, "c" : { "x" : 134, "y" : 919 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 134, "y" : 919 } }, "reactionShape" : { "a" : { "x" : 124, "y" : 887 }, "b" : { "x" : 136, "y" : 899 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 130, "y" : 893 } }, "inputs" : [ { "id" : 98383 } ], "outputs" : [ { "id" : 98400 } ] } ], "shadows" : [ { "id" : 98417, "reactomeId" : 10649588, "displayName" : "IP3 and IP4 transport between cytosol and nucleus", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 914, "y" : 493 }, "minX" : 636, "maxX" : 1193, "minY" : 145, "maxY" : 842, "prop" : { "x" : 636, "y" : 145, "width" : 557, "height" : 697 }, "points" : [ { "x" : 636, "y" : 145 }, { "x" : 1193, "y" : 145 }, { "x" : 1193, "y" : 842 }, { "x" : 636, "y" : 842 } ], "colour" : "#d6ae00" }, { "id" : 98416, "reactomeId" : 10649586, "displayName" : "Synthesis of IPs in the ER lumen", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1447, "y" : 569 }, "minX" : 509, "maxX" : 2385, "minY" : 320, "maxY" : 819, "prop" : { "x" : 2198, "y" : 320, "width" : 187, "height" : 499 }, "points" : [ { "x" : 509, "y" : 320 }, { "x" : 2385, "y" : 320 }, { "x" : 2385, "y" : 819 }, { "x" : 509, "y" : 819 } ], "colour" : "#cb4ac5" }, { "id" : 98418, "reactomeId" : 10649590, "displayName" : "IP6 and IP7 transport between cytosol and nucleus", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1732, "y" : 1018 }, "minX" : 1570, "maxX" : 1894, "minY" : 758, "maxY" : 1279, "prop" : { "x" : 1570, "y" : 758, "width" : 324, "height" : 521 }, "points" : [ { "x" : 1570, "y" : 758 }, { "x" : 1894, "y" : 758 }, { "x" : 1894, "y" : 1279 }, { "x" : 1570, "y" : 1279 } ], "colour" : "#336699" }, { "id" : 98411, "reactomeId" : 10649574, "displayName" : "Synthesis of IP2, IP, and Ins in the cytosol", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 374, "y" : 432 }, "minX" : 16, "maxX" : 733, "minY" : -4, "maxY" : 868, "prop" : { "x" : 16, "y" : -4, "width" : 410, "height" : 872 }, "points" : [ { "x" : 16, "y" : -4 }, { "x" : 733, "y" : -4 }, { "x" : 733, "y" : 868 }, { "x" : 16, "y" : 868 } ], "colour" : "#4684ee" }, { "id" : 98413, "reactomeId" : 10649580, "displayName" : "Synthesis of pyrophosphates in the cytosol", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1946, "y" : 763 }, "minX" : 1694, "maxX" : 2198, "minY" : 175, "maxY" : 1352, "prop" : { "x" : 1894, "y" : 819, "width" : 304, "height" : 460 }, "points" : [ { "x" : 1694, "y" : 175 }, { "x" : 2198, "y" : 175 }, { "x" : 2198, "y" : 1352 }, { "x" : 1694, "y" : 1352 } ], "colour" : "#008000" }, { "id" : 98412, "reactomeId" : 10649578, "displayName" : "Synthesis of IPs in the nucleus", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1373, "y" : 716 }, "minX" : 1065, "maxX" : 1681, "minY" : 145, "maxY" : 1287, "prop" : { "x" : 1193, "y" : 145, "width" : 488, "height" : 175 }, "points" : [ { "x" : 1065, "y" : 145 }, { "x" : 1681, "y" : 145 }, { "x" : 1681, "y" : 1287 }, { "x" : 1065, "y" : 1287 } ], "colour" : "#dc3912" }, { "id" : 98415, "reactomeId" : 10649584, "displayName" : "IPs transport between nucleus and cytosol", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1592, "y" : 790 }, "minX" : 1315, "maxX" : 1869, "minY" : 368, "maxY" : 1213, "prop" : { "x" : 1315, "y" : 368, "width" : 554, "height" : 845 }, "points" : [ { "x" : 1315, "y" : 368 }, { "x" : 1869, "y" : 368 }, { "x" : 1869, "y" : 1213 }, { "x" : 1315, "y" : 1213 } ], "colour" : "#4942cc" }, { "id" : 98414, "reactomeId" : 10649582, "displayName" : "Synthesis of IP3 and IP4 in the cytosol", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 716, "y" : 509 }, "minX" : 426, "maxX" : 1006, "minY" : -8, "maxY" : 1027, "prop" : { "x" : 426, "y" : 868, "width" : 580, "height" : 159 }, "points" : [ { "x" : 426, "y" : -8 }, { "x" : 1006, "y" : -8 }, { "x" : 1006, "y" : 1027 }, { "x" : 426, "y" : 1027 } ], "colour" : "#666666" } ], "minX" : 0, "maxX" : 2433, "minY" : 0, "maxY" : 1457, "disease" : false }