{
  "dbId" : 10649566,
  "stableId" : "R-DRE-2024101",
  "displayName" : "CS/DS degradation",
  "nodes" : [ {
    "id" : 48832,
    "reactomeId" : 1678868,
    "displayName" : "GlcA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1069,
      "y" : 393
    },
    "minX" : 1024,
    "maxX" : 1091,
    "minY" : 377,
    "maxY" : 426,
    "prop" : {
      "x" : 1049,
      "y" : 378,
      "width" : 41,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1052,
      "y" : 383
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1085,
          "y" : 383
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1085,
          "y" : 383
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48830,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1046,
          "y" : 408
        },
        "to" : {
          "x" : 1024,
          "y" : 426
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1043,
          "y" : 415
        },
        "b" : {
          "x" : 1046,
          "y" : 408
        },
        "c" : {
          "x" : 1038,
          "y" : 409
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1038,
          "y" : 409
        }
      }
    } ]
  }, {
    "id" : 48833,
    "reactomeId" : 2090075,
    "displayName" : "linker chain(2)",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1137,
      "y" : 428
    },
    "minX" : 1024,
    "maxX" : 1184,
    "minY" : 412,
    "maxY" : 444,
    "prop" : {
      "x" : 1092,
      "y" : 413,
      "width" : 91,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1097,
      "y" : 411
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1178,
          "y" : 418
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1178,
          "y" : 418
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48830,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1089,
          "y" : 427
        },
        "to" : {
          "x" : 1024,
          "y" : 426
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1082,
          "y" : 431
        },
        "b" : {
          "x" : 1089,
          "y" : 427
        },
        "c" : {
          "x" : 1082,
          "y" : 423
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1082,
          "y" : 423
        }
      }
    } ]
  }, {
    "id" : 48834,
    "reactomeId" : 10597625,
    "displayName" : "GUSB tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1001,
      "y" : 366
    },
    "minX" : 956,
    "maxX" : 1052,
    "minY" : 349,
    "maxY" : 417,
    "prop" : {
      "x" : 956,
      "y" : 355,
      "width" : 90,
      "height" : 23
    },
    "textPosition" : {
      "x" : 969,
      "y" : 343
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1046,
          "y" : 355
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1046,
          "y" : 355
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48830,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1001,
          "y" : 381
        },
        "to" : {
          "x" : 1001,
          "y" : 409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1001,
          "y" : 413
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1001,
          "y" : 413
        }
      }
    } ]
  }, {
    "id" : 48835,
    "reactomeId" : 427963,
    "displayName" : "L-Asp",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1002,
      "y" : 477
    },
    "minX" : 979,
    "maxX" : 1027,
    "minY" : 434,
    "maxY" : 493,
    "prop" : {
      "x" : 979,
      "y" : 462,
      "width" : 47,
      "height" : 31
    },
    "textPosition" : {
      "x" : 982,
      "y" : 467
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1021,
          "y" : 467
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1021,
          "y" : 467
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48830,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1001,
          "y" : 459
        },
        "to" : {
          "x" : 1001,
          "y" : 434
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 997,
          "y" : 434
        },
        "b" : {
          "x" : 1005,
          "y" : 434
        },
        "c" : {
          "x" : 1001,
          "y" : 434
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1001,
          "y" : 434
        }
      }
    } ]
  }, {
    "id" : 48838,
    "reactomeId" : 10597702,
    "displayName" : "D2,4,4(S)3-PGs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 401,
      "y" : 286
    },
    "minX" : 356,
    "maxX" : 446,
    "minY" : 275,
    "maxY" : 298,
    "prop" : {
      "x" : 356,
      "y" : 275,
      "width" : 90,
      "height" : 23
    },
    "textPosition" : {
      "x" : 361,
      "y" : 269
    },
    "connectors" : [ ]
  }, {
    "id" : 48842,
    "reactomeId" : 10599554,
    "displayName" : "CSPGs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 197,
      "y" : 294
    },
    "minX" : 174,
    "maxX" : 220,
    "minY" : 283,
    "maxY" : 306,
    "prop" : {
      "x" : 174,
      "y" : 283,
      "width" : 46,
      "height" : 23
    },
    "textPosition" : {
      "x" : 176,
      "y" : 277
    },
    "connectors" : [ ]
  }, {
    "id" : 48848,
    "reactomeId" : 2065239,
    "displayName" : "Chondroitin chain",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 228,
      "y" : 624
    },
    "minX" : 172,
    "maxX" : 285,
    "minY" : 608,
    "maxY" : 640,
    "prop" : {
      "x" : 172,
      "y" : 609,
      "width" : 112,
      "height" : 31
    },
    "textPosition" : {
      "x" : 186,
      "y" : 607
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 279,
          "y" : 614
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 279,
          "y" : 614
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 48849,
    "reactomeId" : 10649612,
    "displayName" : "CS-GAG biosynthesis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 511,
      "y" : 27
    },
    "minX" : 460,
    "maxX" : 562,
    "minY" : 0,
    "maxY" : 55,
    "prop" : {
      "x" : 460,
      "y" : 0,
      "width" : 102,
      "height" : 55
    },
    "textPosition" : {
      "x" : 464,
      "y" : 6
    },
    "connectors" : [ ]
  }, {
    "id" : 48850,
    "reactomeId" : 10649618,
    "displayName" : "DS-GAG biosynthesis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 656,
      "y" : 28
    },
    "minX" : 606,
    "maxX" : 706,
    "minY" : 2,
    "maxY" : 55,
    "prop" : {
      "x" : 606,
      "y" : 2,
      "width" : 100,
      "height" : 53
    },
    "textPosition" : {
      "x" : 609,
      "y" : 7
    },
    "connectors" : [ ]
  }, {
    "id" : 48811,
    "reactomeId" : 10599510,
    "displayName" : "CSPGs,DSPGs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 193,
      "y" : 46
    },
    "minX" : 150,
    "maxX" : 236,
    "minY" : 35,
    "maxY" : 58,
    "prop" : {
      "x" : 150,
      "y" : 35,
      "width" : 86,
      "height" : 23
    },
    "textPosition" : {
      "x" : 167,
      "y" : 29
    },
    "connectors" : [ {
      "edgeId" : 48810,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 48812,
    "reactomeId" : 10599586,
    "displayName" : "CSPGs,DSPGs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 195,
      "y" : 231
    },
    "minX" : 152,
    "maxX" : 238,
    "minY" : 220,
    "maxY" : 243,
    "prop" : {
      "x" : 152,
      "y" : 220,
      "width" : 86,
      "height" : 23
    },
    "textPosition" : {
      "x" : 169,
      "y" : 214
    },
    "connectors" : [ {
      "edgeId" : 48810,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 48814,
    "reactomeId" : 1605715,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 492,
      "y" : 626
    },
    "minX" : 472,
    "maxX" : 545,
    "minY" : 610,
    "maxY" : 671,
    "prop" : {
      "x" : 472,
      "y" : 611,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 475,
      "y" : 616
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 507,
          "y" : 616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 507,
          "y" : 616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48813,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 510,
          "y" : 645
        },
        "to" : {
          "x" : 545,
          "y" : 671
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 48815,
    "reactomeId" : 2065213,
    "displayName" : "ChEBI:63517 chain",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 607,
      "y" : 626
    },
    "minX" : 545,
    "maxX" : 666,
    "minY" : 610,
    "maxY" : 671,
    "prop" : {
      "x" : 549,
      "y" : 611,
      "width" : 116,
      "height" : 31
    },
    "textPosition" : {
      "x" : 561,
      "y" : 609
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 660,
          "y" : 616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 660,
          "y" : 616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48813,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 585,
          "y" : 645
        },
        "to" : {
          "x" : 545,
          "y" : 671
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 48816,
    "reactomeId" : 2065269,
    "displayName" : "ChEBI:63516 chain",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 739,
      "y" : 670
    },
    "minX" : 613,
    "maxX" : 798,
    "minY" : 654,
    "maxY" : 693,
    "prop" : {
      "x" : 681,
      "y" : 655,
      "width" : 116,
      "height" : 31
    },
    "textPosition" : {
      "x" : 693,
      "y" : 653
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 792,
          "y" : 660
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 792,
          "y" : 660
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48813,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 678,
          "y" : 680
        },
        "to" : {
          "x" : 613,
          "y" : 693
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 672,
          "y" : 685
        },
        "b" : {
          "x" : 678,
          "y" : 680
        },
        "c" : {
          "x" : 670,
          "y" : 677
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 670,
          "y" : 677
        }
      }
    } ]
  }, {
    "id" : 48817,
    "reactomeId" : 1606845,
    "displayName" : "SO4(2-)",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 698,
      "y" : 721
    },
    "minX" : 613,
    "maxX" : 728,
    "minY" : 693,
    "maxY" : 737,
    "prop" : {
      "x" : 669,
      "y" : 706,
      "width" : 58,
      "height" : 31
    },
    "textPosition" : {
      "x" : 670,
      "y" : 711
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 722,
          "y" : 711
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 722,
          "y" : 711
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48813,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 666,
          "y" : 711
        },
        "to" : {
          "x" : 613,
          "y" : 693
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 658,
          "y" : 713
        },
        "b" : {
          "x" : 666,
          "y" : 711
        },
        "c" : {
          "x" : 661,
          "y" : 705
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 661,
          "y" : 705
        }
      }
    } ]
  }, {
    "id" : 48818,
    "reactomeId" : 10597580,
    "displayName" : "IDS dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 457,
      "y" : 695
    },
    "minX" : 427,
    "maxX" : 538,
    "minY" : 678,
    "maxY" : 707,
    "prop" : {
      "x" : 427,
      "y" : 684,
      "width" : 61,
      "height" : 23
    },
    "textPosition" : {
      "x" : 436,
      "y" : 672
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 488,
          "y" : 684
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 488,
          "y" : 684
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48813,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 491,
          "y" : 694
        },
        "to" : {
          "x" : 530,
          "y" : 694
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 534,
          "y" : 694
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 534,
          "y" : 694
        }
      }
    } ]
  }, {
    "id" : 48820,
    "reactomeId" : 1605715,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1070,
      "y" : 731
    },
    "minX" : 1050,
    "maxX" : 1093,
    "minY" : 693,
    "maxY" : 747,
    "prop" : {
      "x" : 1050,
      "y" : 716,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1053,
      "y" : 721
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1085,
          "y" : 721
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1085,
          "y" : 721
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48819,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1079,
          "y" : 713
        },
        "to" : {
          "x" : 1093,
          "y" : 693
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 48821,
    "reactomeId" : 2105025,
    "displayName" : "IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 998,
      "y" : 694
    },
    "minX" : 942,
    "maxX" : 1093,
    "minY" : 671,
    "maxY" : 717,
    "prop" : {
      "x" : 942,
      "y" : 672,
      "width" : 112,
      "height" : 45
    },
    "textPosition" : {
      "x" : 943,
      "y" : 677
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1049,
          "y" : 677
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1049,
          "y" : 677
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48819,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1057,
          "y" : 693
        },
        "to" : {
          "x" : 1093,
          "y" : 693
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 48822,
    "reactomeId" : 2104993,
    "displayName" : "CHEBI:63868 chain",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1238,
      "y" : 649
    },
    "minX" : 1158,
    "maxX" : 1298,
    "minY" : 633,
    "maxY" : 692,
    "prop" : {
      "x" : 1179,
      "y" : 634,
      "width" : 118,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1192,
      "y" : 632
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1292,
          "y" : 639
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1292,
          "y" : 639
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48819,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1209,
          "y" : 668
        },
        "to" : {
          "x" : 1158,
          "y" : 692
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1204,
          "y" : 675
        },
        "b" : {
          "x" : 1209,
          "y" : 668
        },
        "c" : {
          "x" : 1201,
          "y" : 667
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1201,
          "y" : 667
        }
      }
    } ]
  }, {
    "id" : 48823,
    "reactomeId" : 1678617,
    "displayName" : "aldehydo-L-iduronic acid",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1251,
      "y" : 741
    },
    "minX" : 1158,
    "maxX" : 1315,
    "minY" : 692,
    "maxY" : 764,
    "prop" : {
      "x" : 1188,
      "y" : 719,
      "width" : 126,
      "height" : 45
    },
    "textPosition" : {
      "x" : 1207,
      "y" : 724
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1309,
          "y" : 724
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1309,
          "y" : 724
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48819,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1208,
          "y" : 716
        },
        "to" : {
          "x" : 1158,
          "y" : 692
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1200,
          "y" : 717
        },
        "b" : {
          "x" : 1208,
          "y" : 716
        },
        "c" : {
          "x" : 1203,
          "y" : 709
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1203,
          "y" : 709
        }
      }
    } ]
  }, {
    "id" : 48824,
    "reactomeId" : 10597605,
    "displayName" : "idua",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1125,
      "y" : 631
    },
    "minX" : 1104,
    "maxX" : 1152,
    "minY" : 614,
    "maxY" : 685,
    "prop" : {
      "x" : 1104,
      "y" : 620,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1107,
      "y" : 621
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1146,
          "y" : 620
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1146,
          "y" : 620
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48819,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1125,
          "y" : 646
        },
        "to" : {
          "x" : 1125,
          "y" : 677
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1125,
          "y" : 681
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1125,
          "y" : 681
        }
      }
    } ]
  }, {
    "id" : 48826,
    "reactomeId" : 1605715,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 709,
      "y" : 467
    },
    "minX" : 689,
    "maxX" : 746,
    "minY" : 423,
    "maxY" : 483,
    "prop" : {
      "x" : 689,
      "y" : 452,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 692,
      "y" : 457
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 724,
          "y" : 457
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 724,
          "y" : 457
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48825,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 722,
          "y" : 449
        },
        "to" : {
          "x" : 746,
          "y" : 423
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 48827,
    "reactomeId" : 2065257,
    "displayName" : "Chondroitin chains",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 642,
      "y" : 397
    },
    "minX" : 587,
    "maxX" : 746,
    "minY" : 386,
    "maxY" : 423,
    "prop" : {
      "x" : 587,
      "y" : 386,
      "width" : 111,
      "height" : 23
    },
    "textPosition" : {
      "x" : 600,
      "y" : 380
    },
    "connectors" : [ {
      "edgeId" : 48825,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 688,
          "y" : 415
        },
        "to" : {
          "x" : 746,
          "y" : 423
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 48828,
    "reactomeId" : 2065212,
    "displayName" : "CS/HS precursor",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 884,
      "y" : 425
    },
    "minX" : 830,
    "maxX" : 977,
    "minY" : 409,
    "maxY" : 441,
    "prop" : {
      "x" : 830,
      "y" : 410,
      "width" : 109,
      "height" : 31
    },
    "textPosition" : {
      "x" : 850,
      "y" : 408
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 934,
          "y" : 415
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 934,
          "y" : 415
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48825,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 48830,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 942,
          "y" : 426
        },
        "to" : {
          "x" : 977,
          "y" : 427
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 48829,
    "reactomeId" : 10597734,
    "displayName" : "HYAL1-like proteins",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 788,
      "y" : 494
    },
    "minX" : 754,
    "maxX" : 822,
    "minY" : 430,
    "maxY" : 513,
    "prop" : {
      "x" : 754,
      "y" : 475,
      "width" : 68,
      "height" : 38
    },
    "textPosition" : {
      "x" : 758,
      "y" : 470
    },
    "connectors" : [ {
      "edgeId" : 48825,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 787,
          "y" : 469
        },
        "to" : {
          "x" : 787,
          "y" : 438
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 787,
          "y" : 434
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 787,
          "y" : 434
        }
      }
    } ]
  }, {
    "id" : 48831,
    "reactomeId" : 1605715,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 917,
      "y" : 387
    },
    "minX" : 898,
    "maxX" : 977,
    "minY" : 371,
    "maxY" : 427,
    "prop" : {
      "x" : 898,
      "y" : 372,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 900,
      "y" : 377
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 932,
          "y" : 377
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 932,
          "y" : 377
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48830,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 940,
          "y" : 400
        },
        "to" : {
          "x" : 977,
          "y" : 427
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  } ],
  "edges" : [ {
    "id" : 48819,
    "reactomeId" : 10597720,
    "displayName" : "IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1125,
      "y" : 693
    },
    "minX" : 1093,
    "maxX" : 1158,
    "minY" : 687,
    "maxY" : 699,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1093,
        "y" : 693
      },
      "to" : {
        "x" : 1125,
        "y" : 693
      }
    }, {
      "from" : {
        "x" : 1125,
        "y" : 693
      },
      "to" : {
        "x" : 1158,
        "y" : 692
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1119,
        "y" : 687
      },
      "b" : {
        "x" : 1131,
        "y" : 699
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1125,
        "y" : 693
      }
    },
    "inputs" : [ {
      "id" : 48820,
      "points" : [ {
        "x" : 1079,
        "y" : 713
      } ]
    }, {
      "id" : 48821,
      "points" : [ {
        "x" : 1057,
        "y" : 693
      } ]
    } ],
    "outputs" : [ {
      "id" : 48822,
      "points" : [ {
        "x" : 1209,
        "y" : 668
      } ]
    }, {
      "id" : 48823,
      "points" : [ {
        "x" : 1208,
        "y" : 716
      } ]
    } ],
    "catalysts" : [ {
      "id" : 48824,
      "points" : [ {
        "x" : 1125,
        "y" : 646
      } ]
    } ]
  }, {
    "id" : 48825,
    "reactomeId" : 10597737,
    "displayName" : "HYAL1-4 hydrolyze chondroitin chains",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 787,
      "y" : 422
    },
    "minX" : 746,
    "maxX" : 827,
    "minY" : 416,
    "maxY" : 428,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 746,
        "y" : 423
      },
      "to" : {
        "x" : 787,
        "y" : 422
      }
    }, {
      "from" : {
        "x" : 787,
        "y" : 422
      },
      "to" : {
        "x" : 827,
        "y" : 423
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 820,
        "y" : 427
      },
      "b" : {
        "x" : 827,
        "y" : 423
      },
      "c" : {
        "x" : 820,
        "y" : 419
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 820,
        "y" : 419
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 781,
        "y" : 416
      },
      "b" : {
        "x" : 793,
        "y" : 428
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 787,
        "y" : 422
      }
    },
    "inputs" : [ {
      "id" : 48826,
      "points" : [ {
        "x" : 722,
        "y" : 449
      } ]
    }, {
      "id" : 48827,
      "points" : [ {
        "x" : 688,
        "y" : 415
      } ]
    } ],
    "outputs" : [ {
      "id" : 48828
    } ],
    "catalysts" : [ {
      "id" : 48829,
      "points" : [ {
        "x" : 787,
        "y" : 469
      } ]
    } ]
  }, {
    "id" : 48810,
    "reactomeId" : 10599588,
    "displayName" : "DSPG and CSPG translocate to the lysosome for degradation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 194,
      "y" : 133
    },
    "minX" : 188,
    "maxX" : 200,
    "minY" : 64,
    "maxY" : 214,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 193,
        "y" : 64
      },
      "to" : {
        "x" : 194,
        "y" : 133
      }
    }, {
      "from" : {
        "x" : 194,
        "y" : 133
      },
      "to" : {
        "x" : 194,
        "y" : 214
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 190,
        "y" : 207
      },
      "b" : {
        "x" : 194,
        "y" : 214
      },
      "c" : {
        "x" : 198,
        "y" : 207
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 198,
        "y" : 207
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 188,
        "y" : 127
      },
      "b" : {
        "x" : 200,
        "y" : 139
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 194,
        "y" : 133
      }
    },
    "inputs" : [ {
      "id" : 48811
    } ],
    "outputs" : [ {
      "id" : 48812
    } ]
  }, {
    "id" : 48813,
    "reactomeId" : 10597718,
    "displayName" : "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 546,
      "y" : 694
    },
    "minX" : 540,
    "maxX" : 613,
    "minY" : 671,
    "maxY" : 700,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 545,
        "y" : 671
      },
      "to" : {
        "x" : 546,
        "y" : 694
      }
    }, {
      "from" : {
        "x" : 546,
        "y" : 694
      },
      "to" : {
        "x" : 613,
        "y" : 693
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 540,
        "y" : 688
      },
      "b" : {
        "x" : 552,
        "y" : 700
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 546,
        "y" : 694
      }
    },
    "inputs" : [ {
      "id" : 48814,
      "points" : [ {
        "x" : 510,
        "y" : 645
      } ]
    }, {
      "id" : 48815,
      "points" : [ {
        "x" : 585,
        "y" : 645
      } ]
    } ],
    "outputs" : [ {
      "id" : 48816,
      "points" : [ {
        "x" : 678,
        "y" : 680
      } ]
    }, {
      "id" : 48817,
      "points" : [ {
        "x" : 666,
        "y" : 711
      } ]
    } ],
    "catalysts" : [ {
      "id" : 48818,
      "points" : [ {
        "x" : 491,
        "y" : 694
      } ]
    } ]
  }, {
    "id" : 48830,
    "reactomeId" : 10597628,
    "displayName" : "GUSB tetramer hydrolyses CS/HS precursor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1001,
      "y" : 425
    },
    "minX" : 977,
    "maxX" : 1024,
    "minY" : 419,
    "maxY" : 431,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 977,
        "y" : 427
      },
      "to" : {
        "x" : 1001,
        "y" : 425
      }
    }, {
      "from" : {
        "x" : 1001,
        "y" : 425
      },
      "to" : {
        "x" : 1024,
        "y" : 426
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 995,
        "y" : 419
      },
      "b" : {
        "x" : 1007,
        "y" : 431
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1001,
        "y" : 425
      }
    },
    "inputs" : [ {
      "id" : 48828,
      "points" : [ {
        "x" : 942,
        "y" : 426
      } ]
    }, {
      "id" : 48831,
      "points" : [ {
        "x" : 940,
        "y" : 400
      } ]
    } ],
    "outputs" : [ {
      "id" : 48832,
      "points" : [ {
        "x" : 1046,
        "y" : 408
      } ]
    }, {
      "id" : 48833,
      "points" : [ {
        "x" : 1089,
        "y" : 427
      } ]
    } ],
    "catalysts" : [ {
      "id" : 48834,
      "points" : [ {
        "x" : 1001,
        "y" : 381
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 48835,
      "points" : [ {
        "x" : 1001,
        "y" : 459
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 48836,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 697,
      "y" : 441
    },
    "minX" : 0,
    "maxX" : 1395,
    "minY" : 79,
    "maxY" : 804,
    "prop" : {
      "x" : 0,
      "y" : 79,
      "width" : 1395,
      "height" : 725
    },
    "textPosition" : {
      "x" : 631,
      "y" : 97
    },
    "insets" : {
      "x" : 10,
      "y" : 89,
      "width" : 1375,
      "height" : 705
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 48837, 48810 ]
  }, {
    "id" : 48837,
    "reactomeId" : 161320,
    "displayName" : "lysosomal lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 730,
      "y" : 482
    },
    "minX" : 113,
    "maxX" : 1348,
    "minY" : 186,
    "maxY" : 779,
    "prop" : {
      "x" : 113,
      "y" : 186,
      "width" : 1235,
      "height" : 593
    },
    "textPosition" : {
      "x" : 367,
      "y" : 219
    },
    "insets" : {
      "x" : 123,
      "y" : 196,
      "width" : 1215,
      "height" : 573
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 48812, 48854, 48838, 48842, 48855, 48813, 48814, 48815, 48816, 48818, 48817, 48821, 48819, 48820, 48822, 48823, 48824, 48848, 48825, 48826, 48856, 48857, 48829, 48828, 48827, 48830, 48831, 48832, 48833, 48834, 48835 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 48854,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 302,
      "y" : 254
    },
    "minX" : 244,
    "maxX" : 361,
    "minY" : 240,
    "maxY" : 269,
    "segments" : [ {
      "from" : {
        "x" : 361,
        "y" : 269
      },
      "to" : {
        "x" : 244,
        "y" : 240
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 296,
        "y" : 248
      },
      "b" : {
        "x" : 308,
        "y" : 260
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 302,
        "y" : 254
      }
    },
    "inputs" : [ {
      "id" : 48838
    } ],
    "outputs" : [ {
      "id" : 48812
    } ]
  }, {
    "id" : 48855,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 195,
      "y" : 263
    },
    "minX" : 189,
    "maxX" : 201,
    "minY" : 249,
    "maxY" : 277,
    "segments" : [ {
      "from" : {
        "x" : 196,
        "y" : 277
      },
      "to" : {
        "x" : 195,
        "y" : 249
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 189,
        "y" : 257
      },
      "b" : {
        "x" : 201,
        "y" : 269
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 195,
        "y" : 263
      }
    },
    "inputs" : [ {
      "id" : 48842
    } ],
    "outputs" : [ {
      "id" : 48812
    } ]
  }, {
    "id" : 48856,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 431,
      "y" : 623
    },
    "minX" : 287,
    "maxX" : 631,
    "minY" : 415,
    "maxY" : 629,
    "segments" : [ {
      "from" : {
        "x" : 287,
        "y" : 623
      },
      "to" : {
        "x" : 431,
        "y" : 623
      }
    }, {
      "from" : {
        "x" : 431,
        "y" : 623
      },
      "to" : {
        "x" : 631,
        "y" : 415
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 425,
        "y" : 617
      },
      "b" : {
        "x" : 437,
        "y" : 629
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 431,
        "y" : 623
      }
    },
    "inputs" : [ {
      "id" : 48848
    } ],
    "outputs" : [ {
      "id" : 48827
    } ]
  }, {
    "id" : 48858,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 349,
      "y" : 36
    },
    "minX" : 242,
    "maxX" : 457,
    "minY" : 30,
    "maxY" : 43,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 457,
        "y" : 30
      },
      "to" : {
        "x" : 242,
        "y" : 43
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 249,
        "y" : 39
      },
      "b" : {
        "x" : 242,
        "y" : 43
      },
      "c" : {
        "x" : 249,
        "y" : 47
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 249,
        "y" : 47
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 343,
        "y" : 30
      },
      "b" : {
        "x" : 355,
        "y" : 42
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 349,
        "y" : 36
      }
    },
    "inputs" : [ {
      "id" : 48849
    } ],
    "outputs" : [ {
      "id" : 48811
    } ]
  }, {
    "id" : 48859,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 567,
      "y" : 71
    },
    "minX" : 242,
    "maxX" : 603,
    "minY" : 48,
    "maxY" : 77,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 603,
        "y" : 52
      },
      "to" : {
        "x" : 567,
        "y" : 71
      }
    }, {
      "from" : {
        "x" : 567,
        "y" : 71
      },
      "to" : {
        "x" : 242,
        "y" : 48
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 249,
        "y" : 44
      },
      "b" : {
        "x" : 242,
        "y" : 48
      },
      "c" : {
        "x" : 249,
        "y" : 52
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 249,
        "y" : 52
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 561,
        "y" : 65
      },
      "b" : {
        "x" : 573,
        "y" : 77
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 567,
        "y" : 71
      }
    },
    "inputs" : [ {
      "id" : 48850
    } ],
    "outputs" : [ {
      "id" : 48811
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1395,
  "minY" : 0,
  "maxY" : 804,
  "disease" : false
}