{ "dbId" : 10649366, "stableId" : "R-DRE-6783589", "displayName" : "Interleukin-6 family signaling", "nodes" : [ { "id" : 107303, "reactomeId" : 10566308, "displayName" : "Homologues of IL6R-2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 350, "y" : 56 }, "minX" : 317, "maxX" : 413, "minY" : 42, "maxY" : 99, "prop" : { "x" : 317, "y" : 42, "width" : 66, "height" : 29 }, "textPosition" : { "x" : 318, "y" : 32 }, "connectors" : [ { "edgeId" : 107301, "type" : "INPUT", "segments" : [ { "from" : { "x" : 371, "y" : 74 }, "to" : { "x" : 413, "y" : 99 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107302, "reactomeId" : 10566260, "displayName" : "il6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 308, "y" : 128 }, "minX" : 287, "maxX" : 413, "minY" : 99, "maxY" : 204, "prop" : { "x" : 287, "y" : 115, "width" : 42, "height" : 26 }, "textPosition" : { "x" : 297, "y" : 117 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 329, "y" : 115 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 329, "y" : 115 } } }, "connectors" : [ { "edgeId" : 107301, "type" : "INPUT", "segments" : [ { "from" : { "x" : 332, "y" : 122 }, "to" : { "x" : 413, "y" : 99 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 312, "y" : 144 }, "to" : { "x" : 334, "y" : 204 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107304, "reactomeId" : 10566310, "displayName" : "IL6:IL6R-2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 604, "y" : 100 }, "minX" : 566, "maxX" : 730, "minY" : 58, "maxY" : 171, "prop" : { "x" : 566, "y" : 87, "width" : 76, "height" : 27 }, "textPosition" : { "x" : 571, "y" : 93 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 642, "y" : 87 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 642, "y" : 87 } } }, "connectors" : [ { "edgeId" : 107301, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 618, "y" : 84 }, "to" : { "x" : 648, "y" : 58 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107312, "type" : "INPUT", "segments" : [ { "from" : { "x" : 627, "y" : 117 }, "to" : { "x" : 730, "y" : 171 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107307, "reactomeId" : 10593045, "displayName" : "IL6:IL6R-2:IL6ST-2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 770, "y" : 57 }, "minX" : 711, "maxX" : 836, "minY" : 38, "maxY" : 162, "prop" : { "x" : 711, "y" : 44, "width" : 119, "height" : 27 }, "textPosition" : { "x" : 713, "y" : 50 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 830, "y" : 44 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 830, "y" : 44 } } }, "connectors" : [ { "edgeId" : 107305, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107312, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 769, "y" : 74 }, "to" : { "x" : 769, "y" : 162 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 765, "y" : 162 }, "b" : { "x" : 773, "y" : 162 }, "c" : { "x" : 769, "y" : 162 }, "type" : "STOP", "centre" : { "x" : 769, "y" : 162 } } } ] }, { "id" : 107306, "reactomeId" : 10593043, "displayName" : "il6st", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 608, "y" : 19 }, "minX" : 578, "maxX" : 648, "minY" : 0, "maxY" : 58, "prop" : { "x" : 578, "y" : 6, "width" : 61, "height" : 27 }, "textPosition" : { "x" : 591, "y" : 9 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 639, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 639, "y" : 6 } } }, "connectors" : [ { "edgeId" : 107305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 621, "y" : 36 }, "to" : { "x" : 648, "y" : 58 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107309, "reactomeId" : 10566270, "displayName" : "Homologues of IL6R", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 267, "y" : 247 }, "minX" : 241, "maxX" : 334, "minY" : 190, "maxY" : 259, "prop" : { "x" : 241, "y" : 235, "width" : 53, "height" : 24 }, "textPosition" : { "x" : 242, "y" : 223 }, "connectors" : [ { "edgeId" : 107308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 285, "y" : 232 }, "to" : { "x" : 334, "y" : 204 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107385, "type" : "INPUT", "segments" : [ { "from" : { "x" : 264, "y" : 232 }, "to" : { "x" : 255, "y" : 190 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107311, "reactomeId" : 10593058, "displayName" : "IL6R:IL6R inhibitors", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 358, "y" : 251 }, "minX" : 310, "maxX" : 412, "minY" : 210, "maxY" : 270, "prop" : { "x" : 310, "y" : 232, "width" : 96, "height" : 38 }, "textPosition" : { "x" : 325, "y" : 235 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 406, "y" : 232 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 406, "y" : 232 } } }, "connectors" : [ { "edgeId" : 107308, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 364, "y" : 229 }, "to" : { "x" : 371, "y" : 211 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 367, "y" : 210 }, "b" : { "x" : 375, "y" : 212 }, "c" : { "x" : 371, "y" : 211 }, "type" : "STOP", "centre" : { "x" : 371, "y" : 211 } } }, { "edgeId" : 107385, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107310, "reactomeId" : 10566272, "displayName" : "IL6:IL6R", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 453, "y" : 251 }, "minX" : 420, "maxX" : 561, "minY" : 233, "maxY" : 299, "prop" : { "x" : 420, "y" : 239, "width" : 66, "height" : 24 }, "textPosition" : { "x" : 426, "y" : 242 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 486, "y" : 239 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 486, "y" : 239 } } }, "connectors" : [ { "edgeId" : 107308, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 480, "y" : 266 }, "to" : { "x" : 561, "y" : 299 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107313, "reactomeId" : 10593039, "displayName" : "IL6ST:JAK1, JAK2, (TYK2)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 552, "y" : 246 }, "minX" : 280, "maxX" : 730, "minY" : 171, "maxY" : 673, "prop" : { "x" : 510, "y" : 228, "width" : 85, "height" : 37 }, "textPosition" : { "x" : 512, "y" : 230 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 595, "y" : 228 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 595, "y" : 228 } } }, "connectors" : [ { "edgeId" : 107366, "type" : "INPUT", "segments" : [ { "from" : { "x" : 540, "y" : 268 }, "to" : { "x" : 280, "y" : 673 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107312, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 225 }, "to" : { "x" : 730, "y" : 171 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 555, "y" : 268 }, "to" : { "x" : 561, "y" : 299 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107314, "reactomeId" : 10593041, "displayName" : "IL6:sIL6R:IL6RB:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 791, "y" : 250 }, "minX" : 744, "maxX" : 845, "minY" : 226, "maxY" : 269, "prop" : { "x" : 744, "y" : 232, "width" : 95, "height" : 37 }, "textPosition" : { "x" : 756, "y" : 234 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 839, "y" : 232 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 839, "y" : 232 } } }, "connectors" : [ { "edgeId" : 107312, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107316, "reactomeId" : 10593050, "displayName" : "IL6:IL6RA:IL6RB:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 667, "y" : 250 }, "minX" : 626, "maxX" : 715, "minY" : 227, "maxY" : 268, "prop" : { "x" : 626, "y" : 233, "width" : 83, "height" : 35 }, "textPosition" : { "x" : 632, "y" : 233 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 709, "y" : 233 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 709, "y" : 233 } } }, "connectors" : [ { "edgeId" : 107315, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107319, "reactomeId" : 10593054, "displayName" : "IL6 receptor hexamer:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1408, "y" : 253 }, "minX" : 1358, "maxX" : 1465, "minY" : 228, "maxY" : 296, "prop" : { "x" : 1358, "y" : 234, "width" : 101, "height" : 38 }, "textPosition" : { "x" : 1363, "y" : 237 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1459, "y" : 234 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1459, "y" : 234 } } }, "connectors" : [ { "edgeId" : 107317, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1422, "y" : 275 }, "to" : { "x" : 1440, "y" : 296 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107318, "reactomeId" : 10593052, "displayName" : "IL6 receptor trimer:JAKs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1279, "y" : 251 }, "minX" : 1215, "maxX" : 1347, "minY" : 206, "maxY" : 269, "prop" : { "x" : 1215, "y" : 233, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 1215, "y" : 233 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 107317, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1335, "y" : 206 }, "b" : { "x" : 1347, "y" : 218 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1341, "y" : 212 } } } } ] }, { "id" : 107321, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1401, "y" : 340 }, "minX" : 1381, "maxX" : 1440, "minY" : 296, "maxY" : 355, "prop" : { "x" : 1381, "y" : 325, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1385, "y" : 329 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1416, "y" : 330 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1416, "y" : 330 } } }, "connectors" : [ { "edgeId" : 107320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1414, "y" : 322 }, "to" : { "x" : 1440, "y" : 296 } } ], "stoichiometry" : { "value" : 12, "shape" : { "a" : { "x" : 1421, "y" : 303 }, "b" : { "x" : 1433, "y" : 315 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1427, "y" : 309 } } } } ] }, { "id" : 107323, "reactomeId" : 10593075, "displayName" : "IL6 receptor hexamer:Activated JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1615, "y" : 250 }, "minX" : 1505, "maxX" : 1689, "minY" : 219, "maxY" : 297, "prop" : { "x" : 1547, "y" : 225, "width" : 136, "height" : 50 }, "textPosition" : { "x" : 1551, "y" : 226 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1683, "y" : 225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1683, "y" : 225 } } }, "connectors" : [ { "edgeId" : 107320, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1555, "y" : 278 }, "to" : { "x" : 1505, "y" : 296 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1550, "y" : 284 }, "b" : { "x" : 1555, "y" : 278 }, "c" : { "x" : 1547, "y" : 277 }, "type" : "ARROW", "centre" : { "x" : 1547, "y" : 277 } } }, { "edgeId" : 107324, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1636, "y" : 278 }, "to" : { "x" : 1656, "y" : 297 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107322, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1553, "y" : 337 }, "minX" : 1505, "maxX" : 1575, "minY" : 296, "maxY" : 352, "prop" : { "x" : 1533, "y" : 322, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1537, "y" : 326 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1569, "y" : 327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1569, "y" : 327 } } }, "connectors" : [ { "edgeId" : 107320, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1535, "y" : 319 }, "to" : { "x" : 1505, "y" : 296 } } ], "stoichiometry" : { "value" : 12, "shape" : { "a" : { "x" : 1514, "y" : 301 }, "b" : { "x" : 1526, "y" : 313 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1520, "y" : 307 } } }, "endShape" : { "a" : { "x" : 1527, "y" : 318 }, "b" : { "x" : 1535, "y" : 319 }, "c" : { "x" : 1532, "y" : 312 }, "type" : "ARROW", "centre" : { "x" : 1532, "y" : 312 } } } ] }, { "id" : 107325, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1631, "y" : 333 }, "minX" : 1611, "maxX" : 1656, "minY" : 297, "maxY" : 348, "prop" : { "x" : 1611, "y" : 318, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1615, "y" : 322 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1646, "y" : 323 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1646, "y" : 323 } } }, "connectors" : [ { "edgeId" : 107324, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1641, "y" : 315 }, "to" : { "x" : 1656, "y" : 297 } } ], "stoichiometry" : { "value" : 20, "shape" : { "a" : { "x" : 1642, "y" : 300 }, "b" : { "x" : 1654, "y" : 312 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1648, "y" : 306 } } } } ] }, { "id" : 107327, "reactomeId" : 10566316, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1829, "y" : 254 }, "minX" : 1718, "maxX" : 2006, "minY" : 216, "maxY" : 503, "prop" : { "x" : 1767, "y" : 222, "width" : 124, "height" : 64 }, "textPosition" : { "x" : 1765, "y" : 209 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1891, "y" : 222 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1891, "y" : 222 } } }, "connectors" : [ { "edgeId" : 107328, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1862, "y" : 289 }, "to" : { "x" : 2006, "y" : 425 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107336, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1894, "y" : 268 }, "to" : { "x" : 1922, "y" : 276 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107342, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1832, "y" : 289 }, "to" : { "x" : 1858, "y" : 503 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1837, "y" : 295 }, "b" : { "x" : 1832, "y" : 289 }, "c" : { "x" : 1829, "y" : 296 }, "type" : "ARROW", "centre" : { "x" : 1829, "y" : 296 } } }, { "edgeId" : 107324, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1764, "y" : 278 }, "to" : { "x" : 1718, "y" : 297 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1759, "y" : 284 }, "b" : { "x" : 1764, "y" : 278 }, "c" : { "x" : 1756, "y" : 277 }, "type" : "ARROW", "centre" : { "x" : 1756, "y" : 277 } } } ] }, { "id" : 107326, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1752, "y" : 332 }, "minX" : 1718, "maxX" : 1774, "minY" : 297, "maxY" : 347, "prop" : { "x" : 1732, "y" : 317, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1736, "y" : 321 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1768, "y" : 322 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1768, "y" : 322 } } }, "connectors" : [ { "edgeId" : 107324, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1737, "y" : 314 }, "to" : { "x" : 1718, "y" : 297 } } ], "stoichiometry" : { "value" : 20, "shape" : { "a" : { "x" : 1721, "y" : 299 }, "b" : { "x" : 1733, "y" : 311 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1727, "y" : 305 } } }, "endShape" : { "a" : { "x" : 1729, "y" : 312 }, "b" : { "x" : 1737, "y" : 314 }, "c" : { "x" : 1735, "y" : 306 }, "type" : "ARROW", "centre" : { "x" : 1735, "y" : 306 } } } ] }, { "id" : 107329, "reactomeId" : 10581718, "displayName" : "stat1a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1979, "y" : 482 }, "minX" : 1933, "maxX" : 2032, "minY" : 425, "maxY" : 493, "prop" : { "x" : 1933, "y" : 471, "width" : 93, "height" : 22 }, "textPosition" : { "x" : 1955, "y" : 471 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2026, "y" : 471 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2026, "y" : 471 } } }, "connectors" : [ { "edgeId" : 107328, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1984, "y" : 465 }, "to" : { "x" : 2006, "y" : 425 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107330, "reactomeId" : 10593083, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2622, "y" : 433 }, "minX" : 2560, "maxX" : 2690, "minY" : 388, "maxY" : 547, "prop" : { "x" : 2560, "y" : 394, "width" : 124, "height" : 78 }, "textPosition" : { "x" : 2558, "y" : 395 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2684, "y" : 394 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2684, "y" : 394 } } }, "connectors" : [ { "edgeId" : 107328, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107331, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2602, "y" : 475 }, "to" : { "x" : 2583, "y" : 513 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107331, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2622, "y" : 475 }, "to" : { "x" : 2623, "y" : 520 } }, { "from" : { "x" : 2623, "y" : 520 }, "to" : { "x" : 2596, "y" : 540 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2593, "y" : 543 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2593, "y" : 543 } } } ] }, { "id" : 107333, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2505, "y" : 592 }, "minX" : 2486, "maxX" : 2583, "minY" : 573, "maxY" : 611, "prop" : { "x" : 2486, "y" : 574, "width" : 39, "height" : 37 }, "textPosition" : { "x" : 2489, "y" : 582 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2520, "y" : 579 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2520, "y" : 579 } } }, "connectors" : [ { "edgeId" : 107331, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2528, "y" : 588 }, "to" : { "x" : 2583, "y" : 579 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2549, "y" : 577 }, "b" : { "x" : 2561, "y" : 589 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2555, "y" : 583 } } }, "endShape" : { "a" : { "x" : 2534, "y" : 583 }, "b" : { "x" : 2528, "y" : 588 }, "c" : { "x" : 2535, "y" : 591 }, "type" : "ARROW", "centre" : { "x" : 2535, "y" : 591 } } } ] }, { "id" : 107332, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2513, "y" : 489 }, "minX" : 2493, "maxX" : 2583, "minY" : 473, "maxY" : 513, "prop" : { "x" : 2493, "y" : 474, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2497, "y" : 478 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2528, "y" : 479 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2528, "y" : 479 } } }, "connectors" : [ { "edgeId" : 107331, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2536, "y" : 495 }, "to" : { "x" : 2583, "y" : 513 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2553, "y" : 498 }, "b" : { "x" : 2565, "y" : 510 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2559, "y" : 504 } } } } ] }, { "id" : 107335, "reactomeId" : 10593094, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2045, "y" : 255 }, "minX" : 1983, "maxX" : 2574, "minY" : 210, "maxY" : 554, "prop" : { "x" : 1983, "y" : 216, "width" : 124, "height" : 78 }, "textPosition" : { "x" : 1981, "y" : 217 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2107, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2107, "y" : 216 } } }, "connectors" : [ { "edgeId" : 107331, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 2110, "y" : 274 }, "to" : { "x" : 2462, "y" : 387 } }, { "from" : { "x" : 2462, "y" : 387 }, "to" : { "x" : 2463, "y" : 546 } }, { "from" : { "x" : 2463, "y" : 546 }, "to" : { "x" : 2574, "y" : 550 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2574, "y" : 554 }, "b" : { "x" : 2574, "y" : 546 }, "c" : { "x" : 2574, "y" : 550 }, "type" : "STOP", "centre" : { "x" : 2574, "y" : 550 } } }, { "edgeId" : 107336, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107334, "reactomeId" : 10593091, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2632, "y" : 637 }, "minX" : 2537, "maxX" : 2733, "minY" : 579, "maxY" : 709, "prop" : { "x" : 2537, "y" : 605, "width" : 190, "height" : 64 }, "textPosition" : { "x" : 2537, "y" : 606 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2727, "y" : 605 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2727, "y" : 605 } } }, "connectors" : [ { "edgeId" : 107331, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2604, "y" : 602 }, "to" : { "x" : 2583, "y" : 579 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2596, "y" : 600 }, "b" : { "x" : 2604, "y" : 602 }, "c" : { "x" : 2602, "y" : 594 }, "type" : "ARROW", "centre" : { "x" : 2602, "y" : 594 } } }, { "edgeId" : 107338, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2617, "y" : 672 }, "to" : { "x" : 2599, "y" : 709 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107342, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107337, "reactomeId" : 10589000, "displayName" : "socs3b", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1916, "y" : 298 }, "minX" : 1893, "maxX" : 1945, "minY" : 276, "maxY" : 309, "prop" : { "x" : 1893, "y" : 287, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 1893, "y" : 281 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1939, "y" : 287 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1939, "y" : 287 } } }, "connectors" : [ { "edgeId" : 107336, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1919, "y" : 284 }, "to" : { "x" : 1922, "y" : 276 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107339, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2511, "y" : 694 }, "minX" : 2491, "maxX" : 2599, "minY" : 678, "maxY" : 709, "prop" : { "x" : 2491, "y" : 679, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2495, "y" : 683 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2526, "y" : 684 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2526, "y" : 684 } } }, "connectors" : [ { "edgeId" : 107338, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2534, "y" : 697 }, "to" : { "x" : 2599, "y" : 709 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2560, "y" : 697 }, "b" : { "x" : 2572, "y" : 709 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2566, "y" : 703 } } } } ] }, { "id" : 107341, "reactomeId" : 10593120, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2633, "y" : 845 }, "minX" : 2546, "maxX" : 2727, "minY" : 767, "maxY" : 880, "prop" : { "x" : 2546, "y" : 810, "width" : 175, "height" : 70 }, "textPosition" : { "x" : 2550, "y" : 803 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2721, "y" : 810 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2721, "y" : 810 } } }, "connectors" : [ { "edgeId" : 107338, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2617, "y" : 807 }, "to" : { "x" : 2599, "y" : 767 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2611, "y" : 802 }, "b" : { "x" : 2617, "y" : 807 }, "c" : { "x" : 2618, "y" : 799 }, "type" : "ARROW", "centre" : { "x" : 2618, "y" : 799 } } } ] }, { "id" : 107340, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2501, "y" : 832 }, "minX" : 2481, "maxX" : 2599, "minY" : 767, "maxY" : 847, "prop" : { "x" : 2481, "y" : 817, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2485, "y" : 821 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2517, "y" : 822 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2517, "y" : 822 } } }, "connectors" : [ { "edgeId" : 107338, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2525, "y" : 818 }, "to" : { "x" : 2599, "y" : 767 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2556, "y" : 786 }, "b" : { "x" : 2568, "y" : 798 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2562, "y" : 792 } } }, "endShape" : { "a" : { "x" : 2528, "y" : 811 }, "b" : { "x" : 2525, "y" : 818 }, "c" : { "x" : 2533, "y" : 817 }, "type" : "ARROW", "centre" : { "x" : 2533, "y" : 817 } } } ] }, { "id" : 107343, "reactomeId" : 10589062, "displayName" : "phospho-stat1a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2081, "y" : 667 }, "minX" : 1858, "maxX" : 2149, "minY" : 503, "maxY" : 731, "prop" : { "x" : 2019, "y" : 642, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 2027, "y" : 656 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2143, "y" : 642 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2143, "y" : 642 } } }, "connectors" : [ { "edgeId" : 107342, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2047, "y" : 636 }, "to" : { "x" : 1858, "y" : 503 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2039, "y" : 635 }, "b" : { "x" : 2047, "y" : 636 }, "c" : { "x" : 2044, "y" : 629 }, "type" : "ARROW", "centre" : { "x" : 2044, "y" : 629 } } }, { "edgeId" : 107344, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 2075, "y" : 719 }, "b" : { "x" : 2087, "y" : 731 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2081, "y" : 725 } } } } ] }, { "id" : 107345, "reactomeId" : 10589064, "displayName" : "p-Y701-STAT1-1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2085, "y" : 824 }, "minX" : 2020, "maxX" : 2156, "minY" : 779, "maxY" : 864, "prop" : { "x" : 2020, "y" : 785, "width" : 130, "height" : 79 }, "textPosition" : { "x" : 2030, "y" : 807 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2150, "y" : 785 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2150, "y" : 785 } } }, "connectors" : [ { "edgeId" : 107344, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107354, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107347, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1660, "y" : 804 }, "minX" : 1640, "maxX" : 1695, "minY" : 788, "maxY" : 845, "prop" : { "x" : 1640, "y" : 789, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1644, "y" : 793 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1675, "y" : 794 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1675, "y" : 794 } } }, "connectors" : [ { "edgeId" : 107346, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1672, "y" : 822 }, "to" : { "x" : 1695, "y" : 845 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1677, "y" : 827 }, "b" : { "x" : 1689, "y" : 839 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1683, "y" : 833 } } } } ] }, { "id" : 107349, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1805, "y" : 798 }, "minX" : 1750, "maxX" : 1827, "minY" : 782, "maxY" : 845, "prop" : { "x" : 1785, "y" : 783, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1789, "y" : 787 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1821, "y" : 788 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1821, "y" : 788 } } }, "connectors" : [ { "edgeId" : 107346, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1787, "y" : 816 }, "to" : { "x" : 1750, "y" : 845 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1762, "y" : 824 }, "b" : { "x" : 1774, "y" : 836 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1768, "y" : 830 } } }, "endShape" : { "a" : { "x" : 1784, "y" : 823 }, "b" : { "x" : 1787, "y" : 816 }, "c" : { "x" : 1779, "y" : 817 }, "type" : "ARROW", "centre" : { "x" : 1779, "y" : 817 } } } ] }, { "id" : 107348, "reactomeId" : 10593111, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1594, "y" : 879 }, "minX" : 1471, "maxX" : 1725, "minY" : 835, "maxY" : 918, "prop" : { "x" : 1531, "y" : 841, "width" : 126, "height" : 77 }, "textPosition" : { "x" : 1530, "y" : 841 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1657, "y" : 841 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1657, "y" : 841 } } }, "connectors" : [ { "edgeId" : 107346, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1660, "y" : 857 }, "to" : { "x" : 1695, "y" : 845 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107346, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1660, "y" : 897 }, "to" : { "x" : 1720, "y" : 916 } }, { "from" : { "x" : 1720, "y" : 916 }, "to" : { "x" : 1721, "y" : 861 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1721, "y" : 857 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1721, "y" : 857 } } }, { "edgeId" : 107351, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1528, "y" : 861 }, "to" : { "x" : 1471, "y" : 845 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107350, "reactomeId" : 10566318, "displayName" : "IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1865, "y" : 884 }, "minX" : 1750, "maxX" : 1957, "minY" : 839, "maxY" : 924, "prop" : { "x" : 1780, "y" : 845, "width" : 171, "height" : 79 }, "textPosition" : { "x" : 1786, "y" : 847 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1951, "y" : 845 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1951, "y" : 845 } } }, "connectors" : [ { "edgeId" : 107346, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1777, "y" : 855 }, "to" : { "x" : 1750, "y" : 845 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1769, "y" : 856 }, "b" : { "x" : 1777, "y" : 855 }, "c" : { "x" : 1772, "y" : 849 }, "type" : "ARROW", "centre" : { "x" : 1772, "y" : 849 } } } ] }, { "id" : 107353, "reactomeId" : 10593113, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1285, "y" : 850 }, "minX" : 1196, "maxX" : 1381, "minY" : 816, "maxY" : 878, "prop" : { "x" : 1196, "y" : 822, "width" : 179, "height" : 56 }, "textPosition" : { "x" : 1199, "y" : 829 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1375, "y" : 822 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1375, "y" : 822 } } }, "connectors" : [ { "edgeId" : 107351, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107352, "reactomeId" : 10572438, "displayName" : "cbl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1509, "y" : 802 }, "minX" : 1471, "maxX" : 1530, "minY" : 785, "maxY" : 845, "prop" : { "x" : 1494, "y" : 791, "width" : 30, "height" : 22 }, "textPosition" : { "x" : 1496, "y" : 791 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1524, "y" : 791 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1524, "y" : 791 } } }, "connectors" : [ { "edgeId" : 107351, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1499, "y" : 816 }, "to" : { "x" : 1471, "y" : 845 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107355, "reactomeId" : 10593087, "displayName" : "p-Y701-STAT1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2085, "y" : 1020 }, "minX" : 2024, "maxX" : 2152, "minY" : 989, "maxY" : 1045, "prop" : { "x" : 2024, "y" : 995, "width" : 122, "height" : 50 }, "textPosition" : { "x" : 2036, "y" : 1002 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2146, "y" : 995 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2146, "y" : 995 } } }, "connectors" : [ { "edgeId" : 107354, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107357, "reactomeId" : 10620223, "displayName" : "cntfr", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2159, "y" : 252 }, "minX" : 2136, "maxX" : 2392, "minY" : 220, "maxY" : 330, "prop" : { "x" : 2136, "y" : 241, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 2141, "y" : 241 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2183, "y" : 241 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2183, "y" : 241 } } }, "connectors" : [ { "edgeId" : 107356, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2175, "y" : 238 }, "to" : { "x" : 2207, "y" : 220 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107364, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2186, "y" : 259 }, "to" : { "x" : 2392, "y" : 330 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107359, "reactomeId" : 10620233, "displayName" : "CNTF:CNTFR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2264, "y" : 247 }, "minX" : 2221, "maxX" : 2313, "minY" : 228, "maxY" : 260, "prop" : { "x" : 2221, "y" : 234, "width" : 86, "height" : 26 }, "textPosition" : { "x" : 2223, "y" : 239 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2307, "y" : 234 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2307, "y" : 234 } } }, "connectors" : [ { "edgeId" : 107356, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107358, "reactomeId" : 10620231, "displayName" : "m17", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2168, "y" : 202 }, "minX" : 2149, "maxX" : 2207, "minY" : 185, "maxY" : 220, "prop" : { "x" : 2149, "y" : 191, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 2151, "y" : 191 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2188, "y" : 191 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2188, "y" : 191 } } }, "connectors" : [ { "edgeId" : 107356, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2191, "y" : 211 }, "to" : { "x" : 2207, "y" : 220 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107361, "reactomeId" : 10620219, "displayName" : "crlf1a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2339, "y" : 248 }, "minX" : 2317, "maxX" : 2386, "minY" : 217, "maxY" : 259, "prop" : { "x" : 2317, "y" : 237, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 2318, "y" : 237 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2362, "y" : 237 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2362, "y" : 237 } } }, "connectors" : [ { "edgeId" : 107360, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2355, "y" : 234 }, "to" : { "x" : 2386, "y" : 217 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107363, "reactomeId" : 10620221, "displayName" : "CRLF1:CLCF1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2423, "y" : 247 }, "minX" : 2380, "maxX" : 2472, "minY" : 230, "maxY" : 330, "prop" : { "x" : 2380, "y" : 236, "width" : 86, "height" : 22 }, "textPosition" : { "x" : 2380, "y" : 237 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2466, "y" : 236 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2466, "y" : 236 } } }, "connectors" : [ { "edgeId" : 107360, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107364, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2418, "y" : 261 }, "to" : { "x" : 2392, "y" : 330 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107362, "reactomeId" : 10620215, "displayName" : "clcf1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2336, "y" : 201 }, "minX" : 2313, "maxX" : 2386, "minY" : 184, "maxY" : 217, "prop" : { "x" : 2313, "y" : 190, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 2317, "y" : 190 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2359, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2359, "y" : 190 } } }, "connectors" : [ { "edgeId" : 107360, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2362, "y" : 208 }, "to" : { "x" : 2386, "y" : 217 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107365, "reactomeId" : 10620225, "displayName" : "CNTFR:CRLF1:CLCF1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2541, "y" : 248 }, "minX" : 2477, "maxX" : 2612, "minY" : 231, "maxY" : 259, "prop" : { "x" : 2477, "y" : 237, "width" : 129, "height" : 22 }, "textPosition" : { "x" : 2477, "y" : 238 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2606, "y" : 237 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2606, "y" : 237 } } }, "connectors" : [ { "edgeId" : 107364, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107367, "reactomeId" : 10621072, "displayName" : "CNTF:CNTFR,CRLF1:CLCF1:CNTFR", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 173, "y" : 675 }, "minX" : 110, "maxX" : 280, "minY" : 657, "maxY" : 693, "prop" : { "x" : 110, "y" : 657, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 128, "y" : 651 }, "connectors" : [ { "edgeId" : 107366, "type" : "INPUT", "segments" : [ { "from" : { "x" : 242, "y" : 673 }, "to" : { "x" : 280, "y" : 673 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107368, "reactomeId" : 10621074, "displayName" : "CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 195, "y" : 491 }, "minX" : 132, "maxX" : 296, "minY" : 460, "maxY" : 516, "prop" : { "x" : 132, "y" : 466, "width" : 127, "height" : 50 }, "textPosition" : { "x" : 132, "y" : 453 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 259, "y" : 466 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 259, "y" : 466 } } }, "connectors" : [ { "edgeId" : 107366, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107373, "type" : "INPUT", "segments" : [ { "from" : { "x" : 262, "y" : 485 }, "to" : { "x" : 296, "y" : 483 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107371, "reactomeId" : 10620207, "displayName" : "Homologues of LIFR", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 169, "y" : 319 }, "minX" : 153, "maxX" : 221, "minY" : 308, "maxY" : 340, "prop" : { "x" : 153, "y" : 308, "width" : 32, "height" : 22 }, "textPosition" : { "x" : 153, "y" : 274 }, "connectors" : [ { "edgeId" : 107369, "type" : "INPUT", "segments" : [ { "from" : { "x" : 188, "y" : 325 }, "to" : { "x" : 221, "y" : 340 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107370, "reactomeId" : 10593035, "displayName" : "JAK1, JAK2, (TYK2)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 388, "y" : 388 }, "minX" : 221, "maxX" : 431, "minY" : 340, "maxY" : 1054, "prop" : { "x" : 345, "y" : 369, "width" : 86, "height" : 39 }, "textPosition" : { "x" : 350, "y" : 371 }, "connectors" : [ { "edgeId" : 107369, "type" : "INPUT", "segments" : [ { "from" : { "x" : 339, "y" : 375 }, "to" : { "x" : 221, "y" : 340 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107379, "type" : "INPUT", "segments" : [ { "from" : { "x" : 388, "y" : 414 }, "to" : { "x" : 389, "y" : 1054 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107372, "reactomeId" : 10620209, "displayName" : "JAKs:LIFR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 166, "y" : 382 }, "minX" : 134, "maxX" : 311, "minY" : 365, "maxY" : 727, "prop" : { "x" : 134, "y" : 371, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 135, "y" : 372 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 198, "y" : 371 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 198, "y" : 371 } } }, "connectors" : [ { "edgeId" : 107369, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107373, "type" : "INPUT", "segments" : [ { "from" : { "x" : 180, "y" : 396 }, "to" : { "x" : 296, "y" : 483 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 107382, "type" : "INPUT", "segments" : [ { "from" : { "x" : 187, "y" : 396 }, "to" : { "x" : 311, "y" : 455 } }, { "from" : { "x" : 311, "y" : 455 }, "to" : { "x" : 311, "y" : 727 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107374, "reactomeId" : 10621078, "displayName" : "CNTF:CNTFR,CRLF1:CLCF1:CNTFR:gp130:JAKs:LIFR:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 178, "y" : 608 }, "minX" : 115, "maxX" : 247, "minY" : 570, "maxY" : 640, "prop" : { "x" : 115, "y" : 576, "width" : 126, "height" : 64 }, "textPosition" : { "x" : 116, "y" : 577 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 241, "y" : 576 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 241, "y" : 576 } } }, "connectors" : [ { "edgeId" : 107373, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107377, "reactomeId" : 10620211, "displayName" : "CTF1:LIFR:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 172, "y" : 825 }, "minX" : 6, "maxX" : 236, "minY" : 801, "maxY" : 883, "prop" : { "x" : 115, "y" : 807, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 125, "y" : 814 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 230, "y" : 807 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 230, "y" : 807 } } }, "connectors" : [ { "edgeId" : 107375, "type" : "INPUT", "segments" : [ { "from" : { "x" : 120, "y" : 849 }, "to" : { "x" : 6, "y" : 883 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107376, "reactomeId" : 10593037, "displayName" : "il6st", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 167, "y" : 273 }, "minX" : 6, "maxX" : 200, "minY" : 256, "maxY" : 883, "prop" : { "x" : 140, "y" : 262, "width" : 54, "height" : 23 }, "textPosition" : { "x" : 150, "y" : 263 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 194, "y" : 262 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 194, "y" : 262 } } }, "connectors" : [ { "edgeId" : 107375, "type" : "INPUT", "segments" : [ { "from" : { "x" : 141, "y" : 288 }, "to" : { "x" : 6, "y" : 347 } }, { "from" : { "x" : 6, "y" : 347 }, "to" : { "x" : 6, "y" : 883 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107378, "reactomeId" : 10621068, "displayName" : "LIF,OSM receptor complex:gp130", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 168, "y" : 1091 }, "minX" : 111, "maxX" : 232, "minY" : 1067, "maxY" : 1109, "prop" : { "x" : 111, "y" : 1073, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 110, "y" : 1074 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 226, "y" : 1073 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 226, "y" : 1073 } } }, "connectors" : [ { "edgeId" : 107375, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107381, "reactomeId" : 10621186, "displayName" : "JAKs:OSMR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 174, "y" : 1160 }, "minX" : 137, "maxX" : 218, "minY" : 1143, "maxY" : 1171, "prop" : { "x" : 137, "y" : 1149, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 138, "y" : 1150 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 212, "y" : 1149 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 212, "y" : 1149 } } }, "connectors" : [ { "edgeId" : 107379, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107380, "reactomeId" : 10621184, "displayName" : "lifra", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 174, "y" : 1217 }, "minX" : 152, "maxX" : 389, "minY" : 1054, "maxY" : 1228, "prop" : { "x" : 152, "y" : 1206, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 158, "y" : 1206 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 196, "y" : 1206 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 196, "y" : 1206 } } }, "connectors" : [ { "edgeId" : 107379, "type" : "INPUT", "segments" : [ { "from" : { "x" : 188, "y" : 1203 }, "to" : { "x" : 389, "y" : 1054 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107383, "reactomeId" : 10620197, "displayName" : "clcf1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 128, "y" : 727 }, "minX" : 109, "maxX" : 311, "minY" : 710, "maxY" : 738, "prop" : { "x" : 109, "y" : 716, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 110, "y" : 716 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 148, "y" : 716 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 148, "y" : 716 } } }, "connectors" : [ { "edgeId" : 107382, "type" : "INPUT", "segments" : [ { "from" : { "x" : 151, "y" : 727 }, "to" : { "x" : 311, "y" : 727 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107384, "reactomeId" : 10620211, "displayName" : "CTF1:LIFR:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 176, "y" : 769 }, "minX" : 128, "maxX" : 231, "minY" : 752, "maxY" : 780, "prop" : { "x" : 128, "y" : 758, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 129, "y" : 759 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 225, "y" : 758 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 225, "y" : 758 } } }, "connectors" : [ { "edgeId" : 107382, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 107386, "reactomeId" : 9715042, "displayName" : "IL6R inhibitors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 173, "y" : 156 }, "minX" : 128, "maxX" : 255, "minY" : 145, "maxY" : 190, "prop" : { "x" : 128, "y" : 145, "width" : 91, "height" : 22 }, "textPosition" : { "x" : 140, "y" : 139 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 107385, "type" : "INPUT", "segments" : [ { "from" : { "x" : 199, "y" : 173 }, "to" : { "x" : 255, "y" : 190 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 107328, "reactomeId" : 10593085, "displayName" : "Tyrosine phosphorylated IL6ST binds STAT1,STAT3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2365, "y" : 429 }, "minX" : 2006, "maxX" : 2557, "minY" : 423, "maxY" : 435, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2006, "y" : 425 }, "to" : { "x" : 2365, "y" : 429 } }, { "from" : { "x" : 2365, "y" : 429 }, "to" : { "x" : 2557, "y" : 432 } } ], "endShape" : { "a" : { "x" : 2550, "y" : 436 }, "b" : { "x" : 2557, "y" : 432 }, "c" : { "x" : 2550, "y" : 428 }, "type" : "ARROW", "centre" : { "x" : 2550, "y" : 428 } }, "reactionShape" : { "c" : { "x" : 2365, "y" : 429 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2365, "y" : 429 } }, "inputs" : [ { "id" : 107327, "points" : [ { "x" : 1862, "y" : 289 } ] }, { "id" : 107329, "points" : [ { "x" : 1984, "y" : 465 } ] } ], "outputs" : [ { "id" : 107330 } ] }, { "id" : 107331, "reactomeId" : 10593096, "displayName" : "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2583, "y" : 550 }, "minX" : 2577, "maxX" : 2589, "minY" : 513, "maxY" : 579, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2583, "y" : 513 }, "to" : { "x" : 2583, "y" : 550 } }, { "from" : { "x" : 2583, "y" : 550 }, "to" : { "x" : 2583, "y" : 579 } } ], "reactionShape" : { "a" : { "x" : 2577, "y" : 544 }, "b" : { "x" : 2589, "y" : 556 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2583, "y" : 550 } }, "inputs" : [ { "id" : 107330, "points" : [ { "x" : 2602, "y" : 475 } ] }, { "id" : 107332, "points" : [ { "x" : 2536, "y" : 495 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 107333, "points" : [ { "x" : 2528, "y" : 588 } ], "stoichiometry" : 2 }, { "id" : 107334, "points" : [ { "x" : 2604, "y" : 602 } ] } ], "catalysts" : [ { "id" : 107330, "points" : [ { "x" : 2622, "y" : 475 }, { "x" : 2623, "y" : 520 } ] } ], "inhibitors" : [ { "id" : 107335, "points" : [ { "x" : 2110, "y" : 274 }, { "x" : 2462, "y" : 387 }, { "x" : 2463, "y" : 546 } ] } ] }, { "id" : 107336, "reactomeId" : 10593124, "displayName" : "SOCS3 binds IL6ST", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1948, "y" : 276 }, "minX" : 1922, "maxX" : 1980, "minY" : 268, "maxY" : 282, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1922, "y" : 276 }, "to" : { "x" : 1948, "y" : 276 } }, { "from" : { "x" : 1948, "y" : 276 }, "to" : { "x" : 1980, "y" : 268 } } ], "endShape" : { "a" : { "x" : 1974, "y" : 274 }, "b" : { "x" : 1980, "y" : 268 }, "c" : { "x" : 1972, "y" : 266 }, "type" : "ARROW", "centre" : { "x" : 1972, "y" : 266 } }, "reactionShape" : { "c" : { "x" : 1948, "y" : 276 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1948, "y" : 276 } }, "inputs" : [ { "id" : 107337, "points" : [ { "x" : 1919, "y" : 284 } ] }, { "id" : 107327, "points" : [ { "x" : 1894, "y" : 268 } ] } ], "outputs" : [ { "id" : 107335 } ] }, { "id" : 107338, "reactomeId" : 10593122, "displayName" : "Serine phosphorylation of STATs", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2599, "y" : 740 }, "minX" : 2593, "maxX" : 2605, "minY" : 709, "maxY" : 767, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2599, "y" : 709 }, "to" : { "x" : 2599, "y" : 740 } }, { "from" : { "x" : 2599, "y" : 740 }, "to" : { "x" : 2599, "y" : 767 } } ], "reactionShape" : { "a" : { "x" : 2593, "y" : 734 }, "b" : { "x" : 2605, "y" : 746 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2599, "y" : 740 } }, "inputs" : [ { "id" : 107334, "points" : [ { "x" : 2617, "y" : 672 } ] }, { "id" : 107339, "points" : [ { "x" : 2534, "y" : 697 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 107340, "points" : [ { "x" : 2525, "y" : 818 } ], "stoichiometry" : 2 }, { "id" : 107341, "points" : [ { "x" : 2617, "y" : 807 } ] } ] }, { "id" : 107342, "reactomeId" : 10593099, "displayName" : "Phosphorylated STATs are released", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2377, "y" : 635 }, "minX" : 1858, "maxX" : 2534, "minY" : 503, "maxY" : 641, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 2534, "y" : 636 }, "to" : { "x" : 2377, "y" : 635 } }, { "from" : { "x" : 2377, "y" : 635 }, "to" : { "x" : 1858, "y" : 503 } } ], "reactionShape" : { "c" : { "x" : 2377, "y" : 635 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 2377, "y" : 635 } }, "inputs" : [ { "id" : 107334 } ], "outputs" : [ { "id" : 107343, "points" : [ { "x" : 2047, "y" : 636 } ] }, { "id" : 107327, "points" : [ { "x" : 1832, "y" : 289 } ] } ] }, { "id" : 107344, "reactomeId" : 10593081, "displayName" : "Phosphorylated STAT1, STAT3 form dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2081, "y" : 752 }, "minX" : 2075, "maxX" : 2087, "minY" : 698, "maxY" : 779, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2081, "y" : 698 }, "to" : { "x" : 2081, "y" : 752 } }, { "from" : { "x" : 2081, "y" : 752 }, "to" : { "x" : 2082, "y" : 779 } } ], "endShape" : { "a" : { "x" : 2078, "y" : 772 }, "b" : { "x" : 2082, "y" : 779 }, "c" : { "x" : 2086, "y" : 772 }, "type" : "ARROW", "centre" : { "x" : 2086, "y" : 772 } }, "reactionShape" : { "c" : { "x" : 2081, "y" : 752 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2081, "y" : 752 } }, "inputs" : [ { "id" : 107343, "stoichiometry" : 3 } ], "outputs" : [ { "id" : 107345 } ] }, { "id" : 107346, "reactomeId" : 10593118, "displayName" : "PTPN11 is phosphorylated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1721, "y" : 845 }, "minX" : 1695, "maxX" : 1750, "minY" : 839, "maxY" : 851, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1695, "y" : 845 }, "to" : { "x" : 1721, "y" : 845 } }, { "from" : { "x" : 1721, "y" : 845 }, "to" : { "x" : 1750, "y" : 845 } } ], "reactionShape" : { "a" : { "x" : 1715, "y" : 839 }, "b" : { "x" : 1727, "y" : 851 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1721, "y" : 845 } }, "inputs" : [ { "id" : 107347, "points" : [ { "x" : 1672, "y" : 822 } ], "stoichiometry" : 2 }, { "id" : 107348, "points" : [ { "x" : 1660, "y" : 857 } ] } ], "outputs" : [ { "id" : 107349, "points" : [ { "x" : 1787, "y" : 816 } ], "stoichiometry" : 2 }, { "id" : 107350, "points" : [ { "x" : 1777, "y" : 855 } ] } ], "catalysts" : [ { "id" : 107348, "points" : [ { "x" : 1660, "y" : 897 }, { "x" : 1720, "y" : 916 } ] } ] }, { "id" : 107351, "reactomeId" : 10593115, "displayName" : "PTPN11 binds CBL", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1424, "y" : 845 }, "minX" : 1378, "maxX" : 1471, "minY" : 839, "maxY" : 851, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1471, "y" : 845 }, "to" : { "x" : 1424, "y" : 845 } }, { "from" : { "x" : 1424, "y" : 845 }, "to" : { "x" : 1378, "y" : 846 } } ], "endShape" : { "a" : { "x" : 1385, "y" : 842 }, "b" : { "x" : 1378, "y" : 846 }, "c" : { "x" : 1385, "y" : 850 }, "type" : "ARROW", "centre" : { "x" : 1385, "y" : 850 } }, "reactionShape" : { "c" : { "x" : 1424, "y" : 845 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1424, "y" : 845 } }, "inputs" : [ { "id" : 107348, "points" : [ { "x" : 1528, "y" : 861 } ] }, { "id" : 107352, "points" : [ { "x" : 1499, "y" : 816 } ] } ], "outputs" : [ { "id" : 107353 } ] }, { "id" : 107354, "reactomeId" : 10593089, "displayName" : "STAT1 and STAT3 dimers translocate to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2084, "y" : 913 }, "minX" : 2078, "maxX" : 2090, "minY" : 870, "maxY" : 989, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2084, "y" : 870 }, "to" : { "x" : 2084, "y" : 913 } }, { "from" : { "x" : 2084, "y" : 913 }, "to" : { "x" : 2084, "y" : 989 } } ], "endShape" : { "a" : { "x" : 2080, "y" : 982 }, "b" : { "x" : 2084, "y" : 989 }, "c" : { "x" : 2088, "y" : 982 }, "type" : "ARROW", "centre" : { "x" : 2088, "y" : 982 } }, "reactionShape" : { "a" : { "x" : 2078, "y" : 907 }, "b" : { "x" : 2090, "y" : 919 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2084, "y" : 913 } }, "inputs" : [ { "id" : 107345 } ], "outputs" : [ { "id" : 107355 } ] }, { "id" : 107356, "reactomeId" : 10620235, "displayName" : "CNTF binds CNTFR complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2236, "y" : 220 }, "minX" : 2207, "maxX" : 2250, "minY" : 214, "maxY" : 231, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2207, "y" : 220 }, "to" : { "x" : 2236, "y" : 220 } }, { "from" : { "x" : 2236, "y" : 220 }, "to" : { "x" : 2250, "y" : 231 } } ], "endShape" : { "a" : { "x" : 2242, "y" : 230 }, "b" : { "x" : 2250, "y" : 231 }, "c" : { "x" : 2247, "y" : 224 }, "type" : "ARROW", "centre" : { "x" : 2247, "y" : 224 } }, "reactionShape" : { "c" : { "x" : 2236, "y" : 220 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2236, "y" : 220 } }, "inputs" : [ { "id" : 107357, "points" : [ { "x" : 2175, "y" : 238 } ] }, { "id" : 107358, "points" : [ { "x" : 2191, "y" : 211 } ] } ], "outputs" : [ { "id" : 107359 } ] }, { "id" : 107360, "reactomeId" : 10621082, "displayName" : "CRLF1 binds CLCF1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2414, "y" : 216 }, "minX" : 2386, "maxX" : 2420, "minY" : 210, "maxY" : 233, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2386, "y" : 217 }, "to" : { "x" : 2414, "y" : 216 } }, { "from" : { "x" : 2414, "y" : 216 }, "to" : { "x" : 2419, "y" : 233 } } ], "endShape" : { "a" : { "x" : 2413, "y" : 227 }, "b" : { "x" : 2419, "y" : 233 }, "c" : { "x" : 2421, "y" : 225 }, "type" : "ARROW", "centre" : { "x" : 2421, "y" : 225 } }, "reactionShape" : { "c" : { "x" : 2414, "y" : 216 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2414, "y" : 216 } }, "inputs" : [ { "id" : 107361, "points" : [ { "x" : 2355, "y" : 234 } ] }, { "id" : 107362, "points" : [ { "x" : 2362, "y" : 208 } ] } ], "outputs" : [ { "id" : 107363 } ] }, { "id" : 107301, "reactomeId" : 10593033, "displayName" : "IL6 binds IL6R-2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 414, "y" : 99 }, "minX" : 408, "maxX" : 563, "minY" : 93, "maxY" : 105, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 413, "y" : 99 }, "to" : { "x" : 414, "y" : 99 } }, { "from" : { "x" : 414, "y" : 99 }, "to" : { "x" : 563, "y" : 99 } } ], "endShape" : { "a" : { "x" : 556, "y" : 103 }, "b" : { "x" : 563, "y" : 99 }, "c" : { "x" : 556, "y" : 95 }, "type" : "ARROW", "centre" : { "x" : 556, "y" : 95 } }, "reactionShape" : { "c" : { "x" : 414, "y" : 99 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 414, "y" : 99 } }, "inputs" : [ { "id" : 107302, "points" : [ { "x" : 332, "y" : 122 } ] }, { "id" : 107303, "points" : [ { "x" : 371, "y" : 74 } ] } ], "outputs" : [ { "id" : 107304 } ] }, { "id" : 107364, "reactomeId" : 10620227, "displayName" : "CRLF1:CLCF1 binds CNTRF", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2432, "y" : 329 }, "minX" : 2392, "maxX" : 2526, "minY" : 262, "maxY" : 335, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2392, "y" : 330 }, "to" : { "x" : 2432, "y" : 329 } }, { "from" : { "x" : 2432, "y" : 329 }, "to" : { "x" : 2526, "y" : 262 } } ], "endShape" : { "a" : { "x" : 2523, "y" : 269 }, "b" : { "x" : 2526, "y" : 262 }, "c" : { "x" : 2518, "y" : 263 }, "type" : "ARROW", "centre" : { "x" : 2518, "y" : 263 } }, "reactionShape" : { "c" : { "x" : 2432, "y" : 329 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2432, "y" : 329 } }, "inputs" : [ { "id" : 107363, "points" : [ { "x" : 2418, "y" : 261 } ] }, { "id" : 107357, "points" : [ { "x" : 2186, "y" : 259 } ] } ], "outputs" : [ { "id" : 107365 } ] }, { "id" : 107366, "reactomeId" : 10621076, "displayName" : "gp130:JAKs bind CNTFR", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 280, "y" : 516 }, "minX" : 262, "maxX" : 286, "minY" : 509, "maxY" : 673, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 280, "y" : 673 }, "to" : { "x" : 280, "y" : 516 } }, { "from" : { "x" : 280, "y" : 516 }, "to" : { "x" : 262, "y" : 509 } } ], "endShape" : { "a" : { "x" : 270, "y" : 508 }, "b" : { "x" : 262, "y" : 509 }, "c" : { "x" : 267, "y" : 515 }, "type" : "ARROW", "centre" : { "x" : 267, "y" : 515 } }, "reactionShape" : { "c" : { "x" : 280, "y" : 516 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 280, "y" : 516 } }, "inputs" : [ { "id" : 107313, "points" : [ { "x" : 540, "y" : 268 } ] }, { "id" : 107367, "points" : [ { "x" : 242, "y" : 673 } ] } ], "outputs" : [ { "id" : 107368 } ] }, { "id" : 107305, "reactomeId" : 10593063, "displayName" : "IL6:IL6R-2 binds IL6ST-2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 678, "y" : 57 }, "minX" : 642, "maxX" : 708, "minY" : 52, "maxY" : 64, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 648, "y" : 58 }, "to" : { "x" : 678, "y" : 57 } }, { "from" : { "x" : 678, "y" : 57 }, "to" : { "x" : 708, "y" : 57 } } ], "endShape" : { "a" : { "x" : 701, "y" : 61 }, "b" : { "x" : 708, "y" : 57 }, "c" : { "x" : 701, "y" : 53 }, "type" : "ARROW", "centre" : { "x" : 701, "y" : 53 } }, "reactionShape" : { "c" : { "x" : 678, "y" : 57 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 678, "y" : 57 } }, "inputs" : [ { "id" : 107306, "points" : [ { "x" : 621, "y" : 36 } ] }, { "id" : 107304, "points" : [ { "x" : 618, "y" : 84 } ] } ], "outputs" : [ { "id" : 107307 } ] }, { "id" : 107369, "reactomeId" : 10621182, "displayName" : "JAKs bind LIFR", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 220, "y" : 367 }, "minX" : 201, "maxX" : 226, "minY" : 340, "maxY" : 373, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 221, "y" : 340 }, "to" : { "x" : 220, "y" : 367 } }, { "from" : { "x" : 220, "y" : 367 }, "to" : { "x" : 201, "y" : 373 } } ], "endShape" : { "a" : { "x" : 206, "y" : 367 }, "b" : { "x" : 201, "y" : 373 }, "c" : { "x" : 209, "y" : 375 }, "type" : "ARROW", "centre" : { "x" : 209, "y" : 375 } }, "reactionShape" : { "c" : { "x" : 220, "y" : 367 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 220, "y" : 367 } }, "inputs" : [ { "id" : 107370, "points" : [ { "x" : 339, "y" : 375 } ] }, { "id" : 107371, "points" : [ { "x" : 188, "y" : 325 } ] } ], "outputs" : [ { "id" : 107372 } ] }, { "id" : 107373, "reactomeId" : 10621080, "displayName" : "LIFR:JAKs bind gp130:JAKs:CNTFR", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 296, "y" : 608 }, "minX" : 244, "maxX" : 302, "minY" : 483, "maxY" : 614, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 296, "y" : 483 }, "to" : { "x" : 296, "y" : 608 } }, { "from" : { "x" : 296, "y" : 608 }, "to" : { "x" : 244, "y" : 608 } } ], "endShape" : { "a" : { "x" : 251, "y" : 604 }, "b" : { "x" : 244, "y" : 608 }, "c" : { "x" : 251, "y" : 612 }, "type" : "ARROW", "centre" : { "x" : 251, "y" : 612 } }, "reactionShape" : { "c" : { "x" : 296, "y" : 608 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 296, "y" : 608 } }, "inputs" : [ { "id" : 107372, "points" : [ { "x" : 180, "y" : 396 } ] }, { "id" : 107368, "points" : [ { "x" : 262, "y" : 485 } ] } ], "outputs" : [ { "id" : 107374 } ] }, { "id" : 107308, "reactomeId" : 10593060, "displayName" : "IL6 binds IL6R", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 375, "y" : 203 }, "minX" : 334, "maxX" : 433, "minY" : 197, "maxY" : 236, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 334, "y" : 204 }, "to" : { "x" : 375, "y" : 203 } }, { "from" : { "x" : 375, "y" : 203 }, "to" : { "x" : 433, "y" : 236 } } ], "endShape" : { "a" : { "x" : 425, "y" : 236 }, "b" : { "x" : 433, "y" : 236 }, "c" : { "x" : 429, "y" : 229 }, "type" : "ARROW", "centre" : { "x" : 429, "y" : 229 } }, "reactionShape" : { "c" : { "x" : 375, "y" : 203 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 375, "y" : 203 } }, "inputs" : [ { "id" : 107309, "points" : [ { "x" : 285, "y" : 232 } ] }, { "id" : 107302, "points" : [ { "x" : 312, "y" : 144 } ] } ], "outputs" : [ { "id" : 107310 } ], "inhibitors" : [ { "id" : 107311, "points" : [ { "x" : 364, "y" : 229 } ] } ] }, { "id" : 107375, "reactomeId" : 10621070, "displayName" : "OSM,LIF,CTF1 receptor complex binds gp130", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 79, "y" : 976 }, "minX" : 0, "maxX" : 153, "minY" : 877, "maxY" : 1070, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 6, "y" : 883 }, "to" : { "x" : 79, "y" : 976 } }, { "from" : { "x" : 79, "y" : 976 }, "to" : { "x" : 153, "y" : 1070 } } ], "endShape" : { "a" : { "x" : 146, "y" : 1067 }, "b" : { "x" : 153, "y" : 1070 }, "c" : { "x" : 152, "y" : 1062 }, "type" : "ARROW", "centre" : { "x" : 152, "y" : 1062 } }, "reactionShape" : { "c" : { "x" : 79, "y" : 976 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 79, "y" : 976 } }, "inputs" : [ { "id" : 107376, "points" : [ { "x" : 141, "y" : 288 }, { "x" : 6, "y" : 347 } ] }, { "id" : 107377, "points" : [ { "x" : 120, "y" : 849 } ] } ], "outputs" : [ { "id" : 107378 } ] }, { "id" : 107312, "reactomeId" : 10593047, "displayName" : "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 769, "y" : 171 }, "minX" : 730, "maxX" : 785, "minY" : 165, "maxY" : 229, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 730, "y" : 171 }, "to" : { "x" : 769, "y" : 171 } }, { "from" : { "x" : 769, "y" : 171 }, "to" : { "x" : 785, "y" : 229 } } ], "endShape" : { "a" : { "x" : 779, "y" : 223 }, "b" : { "x" : 785, "y" : 229 }, "c" : { "x" : 787, "y" : 221 }, "type" : "ARROW", "centre" : { "x" : 787, "y" : 221 } }, "reactionShape" : { "c" : { "x" : 769, "y" : 171 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 769, "y" : 171 } }, "inputs" : [ { "id" : 107304, "points" : [ { "x" : 627, "y" : 117 } ] }, { "id" : 107313, "points" : [ { "x" : 595, "y" : 225 } ] } ], "outputs" : [ { "id" : 107314 } ], "inhibitors" : [ { "id" : 107307, "points" : [ { "x" : 769, "y" : 74 } ] } ] }, { "id" : 107315, "reactomeId" : 10593065, "displayName" : "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 595, "y" : 285 }, "minX" : 555, "maxX" : 629, "minY" : 271, "maxY" : 305, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 561, "y" : 299 }, "to" : { "x" : 595, "y" : 285 } }, { "from" : { "x" : 595, "y" : 285 }, "to" : { "x" : 629, "y" : 271 } } ], "endShape" : { "a" : { "x" : 624, "y" : 277 }, "b" : { "x" : 629, "y" : 271 }, "c" : { "x" : 621, "y" : 270 }, "type" : "ARROW", "centre" : { "x" : 621, "y" : 270 } }, "reactionShape" : { "c" : { "x" : 595, "y" : 285 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 595, "y" : 285 } }, "inputs" : [ { "id" : 107310, "points" : [ { "x" : 480, "y" : 266 } ] }, { "id" : 107313, "points" : [ { "x" : 555, "y" : 268 } ] } ], "outputs" : [ { "id" : 107316 } ] }, { "id" : 107379, "reactomeId" : 10621188, "displayName" : "JAKs bind OSMR", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 292, "y" : 1100 }, "minX" : 196, "maxX" : 395, "minY" : 1048, "maxY" : 1146, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 389, "y" : 1054 }, "to" : { "x" : 292, "y" : 1100 } }, { "from" : { "x" : 292, "y" : 1100 }, "to" : { "x" : 196, "y" : 1146 } } ], "endShape" : { "a" : { "x" : 201, "y" : 1139 }, "b" : { "x" : 196, "y" : 1146 }, "c" : { "x" : 204, "y" : 1147 }, "type" : "ARROW", "centre" : { "x" : 204, "y" : 1147 } }, "reactionShape" : { "c" : { "x" : 292, "y" : 1100 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 292, "y" : 1100 } }, "inputs" : [ { "id" : 107380, "points" : [ { "x" : 188, "y" : 1203 } ] }, { "id" : 107370, "points" : [ { "x" : 388, "y" : 414 } ] } ], "outputs" : [ { "id" : 107381 } ] }, { "id" : 107317, "reactomeId" : 10593056, "displayName" : "Assembly of hexameric IL-6 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1372, "y" : 198 }, "minX" : 1310, "maxX" : 1395, "minY" : 192, "maxY" : 231, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1310, "y" : 227 }, "to" : { "x" : 1372, "y" : 198 } }, { "from" : { "x" : 1372, "y" : 198 }, "to" : { "x" : 1395, "y" : 231 } } ], "endShape" : { "a" : { "x" : 1388, "y" : 228 }, "b" : { "x" : 1395, "y" : 231 }, "c" : { "x" : 1394, "y" : 223 }, "type" : "ARROW", "centre" : { "x" : 1394, "y" : 223 } }, "reactionShape" : { "c" : { "x" : 1372, "y" : 198 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1372, "y" : 198 } }, "inputs" : [ { "id" : 107318, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 107319 } ] }, { "id" : 107382, "reactomeId" : 10620213, "displayName" : "CTF1 binds LIFR:JAKs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 311, "y" : 728 }, "minX" : 212, "maxX" : 317, "minY" : 722, "maxY" : 755, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 311, "y" : 727 }, "to" : { "x" : 311, "y" : 728 } }, { "from" : { "x" : 311, "y" : 728 }, "to" : { "x" : 212, "y" : 755 } } ], "endShape" : { "a" : { "x" : 218, "y" : 749 }, "b" : { "x" : 212, "y" : 755 }, "c" : { "x" : 220, "y" : 757 }, "type" : "ARROW", "centre" : { "x" : 220, "y" : 757 } }, "reactionShape" : { "c" : { "x" : 311, "y" : 728 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 311, "y" : 728 } }, "inputs" : [ { "id" : 107383, "points" : [ { "x" : 151, "y" : 727 } ] }, { "id" : 107372, "points" : [ { "x" : 187, "y" : 396 }, { "x" : 311, "y" : 455 } ] } ], "outputs" : [ { "id" : 107384 } ] }, { "id" : 107385, "reactomeId" : 10640246, "displayName" : "IL6R binds IL6R inhibitors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 255, "y" : 189 }, "minX" : 249, "maxX" : 326, "minY" : 183, "maxY" : 229, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 255, "y" : 190 }, "to" : { "x" : 255, "y" : 189 } }, { "from" : { "x" : 255, "y" : 189 }, "to" : { "x" : 326, "y" : 229 } } ], "endShape" : { "a" : { "x" : 318, "y" : 229 }, "b" : { "x" : 326, "y" : 229 }, "c" : { "x" : 322, "y" : 222 }, "type" : "ARROW", "centre" : { "x" : 322, "y" : 222 } }, "reactionShape" : { "c" : { "x" : 255, "y" : 189 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 255, "y" : 189 } }, "inputs" : [ { "id" : 107309, "points" : [ { "x" : 264, "y" : 232 } ] }, { "id" : 107386, "points" : [ { "x" : 199, "y" : 173 } ] } ], "outputs" : [ { "id" : 107311 } ] }, { "id" : 107320, "reactomeId" : 10593079, "displayName" : "JAK activation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1471, "y" : 296 }, "minX" : 1440, "maxX" : 1505, "minY" : 290, "maxY" : 302, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1440, "y" : 296 }, "to" : { "x" : 1471, "y" : 296 } }, { "from" : { "x" : 1471, "y" : 296 }, "to" : { "x" : 1505, "y" : 296 } } ], "reactionShape" : { "a" : { "x" : 1465, "y" : 290 }, "b" : { "x" : 1477, "y" : 302 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1471, "y" : 296 } }, "inputs" : [ { "id" : 107319, "points" : [ { "x" : 1422, "y" : 275 } ] }, { "id" : 107321, "points" : [ { "x" : 1414, "y" : 322 } ], "stoichiometry" : 12 } ], "outputs" : [ { "id" : 107322, "points" : [ { "x" : 1535, "y" : 319 } ], "stoichiometry" : 12 }, { "id" : 107323, "points" : [ { "x" : 1555, "y" : 278 } ] } ] }, { "id" : 107324, "reactomeId" : 10593077, "displayName" : "IL6ST is tyrosine phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1686, "y" : 297 }, "minX" : 1656, "maxX" : 1718, "minY" : 291, "maxY" : 303, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1656, "y" : 297 }, "to" : { "x" : 1686, "y" : 297 } }, { "from" : { "x" : 1686, "y" : 297 }, "to" : { "x" : 1718, "y" : 297 } } ], "reactionShape" : { "a" : { "x" : 1680, "y" : 291 }, "b" : { "x" : 1692, "y" : 303 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1686, "y" : 297 } }, "inputs" : [ { "id" : 107325, "points" : [ { "x" : 1641, "y" : 315 } ], "stoichiometry" : 20 }, { "id" : 107323, "points" : [ { "x" : 1636, "y" : 278 } ] } ], "outputs" : [ { "id" : 107326, "points" : [ { "x" : 1737, "y" : 314 } ], "stoichiometry" : 20 }, { "id" : 107327, "points" : [ { "x" : 1764, "y" : 278 } ] } ] } ], "compartments" : [ { "id" : 107389, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1388, "y" : 761 }, "minX" : 161, "maxX" : 2615, "minY" : 245, "maxY" : 1277, "prop" : { "x" : 161, "y" : 245, "width" : 2454, "height" : 1032 }, "textPosition" : { "x" : 624, "y" : 1170 }, "insets" : { "x" : 171, "y" : 255, "width" : 2434, "height" : 1012 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 107370, 107313, 107310, 107314, 107316, 107318, 107319, 107321, 107322, 107323, 107325, 107326, 107327, 107329, 107330, 107332, 107333, 107334, 107335, 107337, 107339, 107340, 107348, 107347, 107349, 107350, 107352, 107353, 107376, 107309, 107315, 107320, 107324, 107328, 107331, 107336, 107338, 107342, 107346, 107351, 107390, 107391, 107341, 107359, 107357, 107361, 107363, 107364, 107365, 107368, 107366, 107367, 107393, 107369, 107372, 107374, 107377, 107378, 107395, 107396, 107379, 107380, 107381, 107397, 107384, 107398, 107354, 107392, 107382, 107371, 107388, 107343, 107344, 107345, 107373, 107311 ] }, { "id" : 107388, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2235, "y" : 1063 }, "minX" : 2002, "maxX" : 2468, "minY" : 961, "maxY" : 1166, "prop" : { "x" : 2002, "y" : 961, "width" : 466, "height" : 205 }, "textPosition" : { "x" : 2023, "y" : 1107 }, "insets" : { "x" : 2012, "y" : 971, "width" : 446, "height" : 185 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 107355 ] } ], "notes" : [ ], "links" : [ { "id" : 107393, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1361, "y" : 462 }, "minX" : 242, "maxX" : 2480, "minY" : 262, "maxY" : 663, "segments" : [ { "from" : { "x" : 2480, "y" : 262 }, "to" : { "x" : 242, "y" : 663 } } ], "reactionShape" : { "a" : { "x" : 1355, "y" : 456 }, "b" : { "x" : 1367, "y" : 468 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1361, "y" : 462 } }, "inputs" : [ { "id" : 107365 } ], "outputs" : [ { "id" : 107367 } ] }, { "id" : 107392, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1230, "y" : 458 }, "minX" : 242, "maxX" : 2218, "minY" : 255, "maxY" : 662, "segments" : [ { "from" : { "x" : 2218, "y" : 255 }, "to" : { "x" : 242, "y" : 662 } } ], "reactionShape" : { "a" : { "x" : 1224, "y" : 452 }, "b" : { "x" : 1236, "y" : 464 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1230, "y" : 458 } }, "inputs" : [ { "id" : 107359 } ], "outputs" : [ { "id" : 107367 } ] }, { "id" : 107398, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 173, "y" : 792 }, "minX" : 167, "maxX" : 179, "minY" : 783, "maxY" : 801, "segments" : [ { "from" : { "x" : 174, "y" : 783 }, "to" : { "x" : 172, "y" : 801 } } ], "reactionShape" : { "a" : { "x" : 167, "y" : 786 }, "b" : { "x" : 179, "y" : 798 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 173, "y" : 792 } }, "inputs" : [ { "id" : 107384 } ], "outputs" : [ { "id" : 107377 } ] }, { "id" : 107391, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 983, "y" : 294 }, "minX" : 807, "maxX" : 1218, "minY" : 272, "maxY" : 300, "segments" : [ { "from" : { "x" : 807, "y" : 272 }, "to" : { "x" : 832, "y" : 295 } }, { "from" : { "x" : 832, "y" : 295 }, "to" : { "x" : 1135, "y" : 294 } }, { "from" : { "x" : 1135, "y" : 294 }, "to" : { "x" : 1218, "y" : 275 } } ], "reactionShape" : { "a" : { "x" : 977, "y" : 288 }, "b" : { "x" : 989, "y" : 300 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 983, "y" : 294 } }, "inputs" : [ { "id" : 107314 } ], "outputs" : [ { "id" : 107318 } ] }, { "id" : 107390, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 981, "y" : 312 }, "minX" : 712, "maxX" : 1238, "minY" : 267, "maxY" : 318, "segments" : [ { "from" : { "x" : 712, "y" : 267 }, "to" : { "x" : 820, "y" : 313 } }, { "from" : { "x" : 820, "y" : 313 }, "to" : { "x" : 1143, "y" : 312 } }, { "from" : { "x" : 1143, "y" : 312 }, "to" : { "x" : 1238, "y" : 275 } } ], "reactionShape" : { "a" : { "x" : 975, "y" : 306 }, "b" : { "x" : 987, "y" : 318 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 981, "y" : 312 } }, "inputs" : [ { "id" : 107316 } ], "outputs" : [ { "id" : 107318 } ] } ], "shadows" : [ { "id" : 107399, "reactomeId" : 10649364, "displayName" : "Interleukin-6 signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1427, "y" : 525 }, "minX" : 118, "maxX" : 2737, "minY" : -4, "maxY" : 1055, "prop" : { "x" : 118, "y" : -4, "width" : 2619, "height" : 184 }, "points" : [ { "x" : 118, "y" : -4 }, { "x" : 2737, "y" : -4 }, { "x" : 2737, "y" : 1055 }, { "x" : 118, "y" : 1055 } ], "colour" : "#4684ee" }, { "id" : 107400, "reactomeId" : 10650126, "displayName" : "IL-6-type cytokine receptor ligand interactions", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1303, "y" : 709 }, "minX" : -10, "maxX" : 2616, "minY" : 180, "maxY" : 1238, "prop" : { "x" : -10, "y" : 1055, "width" : 2626, "height" : 183 }, "points" : [ { "x" : -10, "y" : 180 }, { "x" : 2616, "y" : 180 }, { "x" : 2616, "y" : 1238 }, { "x" : -10, "y" : 1238 } ], "colour" : "#dc3912" } ], "minX" : 0, "maxX" : 2733, "minY" : 0, "maxY" : 1277, "disease" : false }