{
  "dbId" : 10648688,
  "stId" : "R-DRE-202403",
  "speciesName" : "Danio rerio",
  "nodes" : [ {
    "dbId" : 10576033,
    "stId" : "R-DRE-202311",
    "displayName" : "PDK1:PIP2,PIP3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 18969 ],
    "parents" : [ ],
    "children" : [ 10566205, 202277 ]
  }, {
    "dbId" : 10576416,
    "stId" : "R-DRE-203776",
    "displayName" : "CSK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18948 ],
    "identifier" : "A0JMN4",
    "standardIdentifier" : "uniprot:A0JMN4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10630615, 10576418 ],
    "children" : [ ]
  }, {
    "dbId" : 10576418,
    "stId" : "R-DRE-202297",
    "displayName" : "Csk:p-PAG [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 18949 ],
    "parents" : [ ],
    "children" : [ 10572301, 10576416 ]
  }, {
    "dbId" : 10576037,
    "stId" : "R-DRE-202320",
    "displayName" : "plcg1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q804J6",
    "standardIdentifier" : "uniprot:Q804J6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "plcg1" ],
    "parents" : [ 10576056 ],
    "children" : [ ]
  }, {
    "dbId" : 202247,
    "stId" : "R-ALL-202247",
    "displayName" : "PI(3,4)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 19016 ],
    "identifier" : "16152",
    "standardIdentifier" : "chebi:16152",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 202277 ],
    "children" : [ ]
  }, {
    "dbId" : 10576039,
    "stId" : "R-DRE-202364",
    "displayName" : "Ghost homologue of p-5Y-LAT [plasma membrane]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 68323,
    "parents" : [ 10576045 ],
    "children" : [ ]
  }, {
    "dbId" : 10582950,
    "stId" : "R-DRE-390925",
    "displayName" : "si:ch211-188c16.1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18972 ],
    "identifier" : "B3DHD5",
    "standardIdentifier" : "uniprot:B3DHD5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "si:ch211-188c16.1" ],
    "parents" : [ 10585617 ],
    "children" : [ ]
  }, {
    "dbId" : 10576043,
    "stId" : "R-DRE-202367",
    "displayName" : "grap2a [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q567F1",
    "standardIdentifier" : "uniprot:Q567F1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "grap2a" ],
    "parents" : [ 10576045 ],
    "children" : [ ]
  }, {
    "dbId" : 10582570,
    "stId" : "R-DRE-211604",
    "displayName" : "PAK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18978 ],
    "identifier" : "Q6DG42",
    "standardIdentifier" : "uniprot:Q6DG42",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10585623 ],
    "children" : [ ]
  }, {
    "dbId" : 10576045,
    "stId" : "R-DRE-202177",
    "displayName" : "GADS:p-5Y-LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10576054 ],
    "children" : [ 10576043, 10576039 ]
  }, {
    "dbId" : 179856,
    "stId" : "R-ALL-179856",
    "displayName" : "PI(4,5)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 18986, 18958 ],
    "identifier" : "58456",
    "standardIdentifier" : "chebi:58456",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10576086 ],
    "children" : [ ]
  }, {
    "dbId" : 112275,
    "stId" : "R-ALL-112275",
    "displayName" : "DAGs [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 18963 ],
    "identifier" : "18035",
    "standardIdentifier" : "chebi:18035",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10576052,
    "stId" : "R-DRE-202175",
    "displayName" : "phospho-lcp2b [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18971 ],
    "identifier" : "A0A8M3AS66",
    "standardIdentifier" : "uniprot:A0A8M3AS66",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "lcp2b" ],
    "parents" : [ 10585617, 10585621, 10576054 ],
    "children" : [ ]
  }, {
    "dbId" : 10579316,
    "stId" : "R-DRE-197954",
    "displayName" : "nck1b [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18975 ],
    "identifier" : "E7F6M0",
    "standardIdentifier" : "uniprot:E7F6M0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "nck1b" ],
    "parents" : [ 10585621 ],
    "children" : [ ]
  }, {
    "dbId" : 10576054,
    "stId" : "R-DRE-202162",
    "displayName" : "p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10576063, 10576056, 10576069 ],
    "children" : [ 10576045, 10576052 ]
  }, {
    "dbId" : 114520,
    "stId" : "R-ALL-114520",
    "displayName" : "I(1,4,5)P3 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 18964 ],
    "identifier" : "203600",
    "standardIdentifier" : "chebi:203600",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10576056,
    "stId" : "R-DRE-202279",
    "displayName" : "PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 19012, 18951 ],
    "parents" : [ ],
    "children" : [ 10576054, 10576037 ]
  }, {
    "dbId" : 10575224,
    "stId" : "R-DRE-199420",
    "displayName" : "ptenb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18988 ],
    "identifier" : "Q7ZZ56",
    "standardIdentifier" : "uniprot:Q7ZZ56",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ptenb" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10576061,
    "stId" : "R-DRE-202357",
    "displayName" : "phospho-plcg1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18959 ],
    "identifier" : "Q804J6",
    "standardIdentifier" : "uniprot:Q804J6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "plcg1" ],
    "parents" : [ 10576063 ],
    "children" : [ ]
  }, {
    "dbId" : 10566205,
    "stId" : "R-DRE-61459",
    "displayName" : "PDPK1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6NZV1",
    "standardIdentifier" : "uniprot:Q6NZV1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10576033 ],
    "children" : [ ]
  }, {
    "dbId" : 10576063,
    "stId" : "R-DRE-202302",
    "displayName" : "phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 19013, 18953 ],
    "parents" : [ ],
    "children" : [ 10576061, 10576054 ]
  }, {
    "dbId" : 10576067,
    "stId" : "R-DRE-202319",
    "displayName" : "ITK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "O42200",
    "standardIdentifier" : "uniprot:O42200",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10576069 ],
    "children" : [ ]
  }, {
    "dbId" : 10576069,
    "stId" : "R-DRE-202359",
    "displayName" : "ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 19010, 18955 ],
    "parents" : [ ],
    "children" : [ 10576054, 10576067 ]
  }, {
    "dbId" : 202277,
    "stId" : "R-ALL-202277",
    "displayName" : "PIP3, PI(3,4)P2 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 18967 ],
    "parents" : [ 10576033 ],
    "children" : [ 179838, 202247 ]
  }, {
    "dbId" : 10576074,
    "stId" : "R-DRE-8866028",
    "displayName" : "igsf3l [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18956 ],
    "identifier" : "Q6DG17",
    "standardIdentifier" : "uniprot:Q6DG17",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "igsf3l" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29356,
    "stId" : "R-ALL-29356",
    "displayName" : "H2O [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 18962, 18985 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10572301,
    "stId" : "R-DRE-180494",
    "displayName" : "phospho-pag1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18947 ],
    "identifier" : "F6P529",
    "standardIdentifier" : "uniprot:F6P529",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "pag1" ],
    "parents" : [ 10576418 ],
    "children" : [ ]
  }, {
    "dbId" : 10585617,
    "stId" : "R-DRE-430124",
    "displayName" : "p-SLP-76:ADAP [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 18973 ],
    "parents" : [ ],
    "children" : [ 10582950, 10576052 ]
  }, {
    "dbId" : 10585621,
    "stId" : "R-DRE-430188",
    "displayName" : "p-SLP-76:NCK1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 18976 ],
    "parents" : [ 10585623 ],
    "children" : [ 10576052, 10579316 ]
  }, {
    "dbId" : 10576084,
    "stId" : "R-DRE-167679",
    "displayName" : "phospho-plcg1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18965 ],
    "identifier" : "Q804J6",
    "standardIdentifier" : "uniprot:Q804J6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "plcg1" ],
    "parents" : [ 10576086 ],
    "children" : [ ]
  }, {
    "dbId" : 10630615,
    "stId" : "R-DRE-8855376",
    "displayName" : "PTPN22:CSK [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 18981 ],
    "parents" : [ ],
    "children" : [ 10630613, 10576416 ]
  }, {
    "dbId" : 10585623,
    "stId" : "R-DRE-430189",
    "displayName" : "p-SLP-76:NCK:PAK [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 18979 ],
    "parents" : [ ],
    "children" : [ 10582570, 10585621 ]
  }, {
    "dbId" : 10576086,
    "stId" : "R-DRE-202269",
    "displayName" : "Activated PLC gamma1 bound to PIP2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 18960 ],
    "parents" : [ ],
    "children" : [ 10576084, 179856 ]
  }, {
    "dbId" : 10630613,
    "stId" : "R-DRE-8852205",
    "displayName" : "ptpn22 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18982 ],
    "identifier" : "A5D6T3",
    "standardIdentifier" : "uniprot:A5D6T3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ptpn22" ],
    "parents" : [ 10630615 ],
    "children" : [ ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 18952 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 18954 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 179838,
    "stId" : "R-ALL-179838",
    "displayName" : "PI(3,4,5)P3 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 18984 ],
    "identifier" : "57836",
    "standardIdentifier" : "chebi:57836",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 202277 ],
    "children" : [ ]
  }, {
    "dbId" : 29372,
    "stId" : "R-ALL-29372",
    "displayName" : "Pi [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 18987 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10648028,
    "stId" : "R-DRE-1257604",
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 19054 ]
  }, {
    "dbId" : 10576031,
    "stId" : "R-DRE-202210",
    "displayName" : "PDPK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 18968 ],
    "identifier" : "Q6NZV1",
    "standardIdentifier" : "uniprot:Q6NZV1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10585619,
    "stId" : "R-DRE-430135",
    "displayName" : "p-SLP-76 binds ADAP",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10582950, 10576052 ],
    "outputs" : [ 10585617 ],
    "efs" : [ ],
    "diagramIds" : [ 18970 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10576035,
    "stId" : "R-DRE-202164",
    "displayName" : "Translocation of PDK1 to Plasma membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10576031, 202277 ],
    "outputs" : [ 10576033 ],
    "efs" : [ ],
    "diagramIds" : [ 18966 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10576420,
    "stId" : "R-DRE-203774",
    "displayName" : "Interaction of Csk with PAG",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10572301, 10576416 ],
    "outputs" : [ 10576418 ],
    "efs" : [ ],
    "diagramIds" : [ 18946 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10585625,
    "stId" : "R-DRE-430183",
    "displayName" : "NCK binds PAK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10582570, 10585621 ],
    "outputs" : [ 10585623 ],
    "efs" : [ ],
    "diagramIds" : [ 18977 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10576088,
    "stId" : "R-DRE-202354",
    "displayName" : "Translocation of PLC-gamma1 to PIP2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10576076 ],
    "following" : [ 10576091 ],
    "inputs" : [ 10576061, 179856 ],
    "outputs" : [ 10576086 ],
    "efs" : [ ],
    "diagramIds" : [ 18957 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10576091,
    "stId" : "R-DRE-202407",
    "displayName" : "PLC-gamma1 hydrolyses PIP2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10576088 ],
    "inputs" : [ 29356, 179856 ],
    "outputs" : [ 114520, 112275 ],
    "catalysts" : [ 10576084 ],
    "efs" : [ ],
    "diagramIds" : [ 18961 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10585627,
    "stId" : "R-DRE-430190",
    "displayName" : "p-SLP-76 binds NCK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10579316, 10576052 ],
    "outputs" : [ 10585621 ],
    "efs" : [ ],
    "diagramIds" : [ 18974 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10575227,
    "stId" : "R-DRE-199456",
    "displayName" : "PTEN dephosphorylates PIP3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29356, 179838 ],
    "outputs" : [ 29372, 179856 ],
    "catalysts" : [ 10575224 ],
    "efs" : [ ],
    "diagramIds" : [ 18983 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10630617,
    "stId" : "R-DRE-8855375",
    "displayName" : "PTPN22 dissociates from CSK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10630615 ],
    "outputs" : [ 10630613, 10576416 ],
    "efs" : [ ],
    "diagramIds" : [ 18980 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10576076,
    "stId" : "R-DRE-202248",
    "displayName" : "Phosphorylation of PLC-gamma1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10576088 ],
    "inputs" : [ 113592, 10576056 ],
    "outputs" : [ 10576063, 29370 ],
    "catalysts" : [ 10576069 ],
    "efs" : [ ],
    "inhibitors" : [ 10576074 ],
    "diagramIds" : [ 18950 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10648734,
    "stId" : "R-DRE-202427",
    "displayName" : "Phosphorylation of CD3 and TCR zeta chains",
    "events" : [ 10576420, 10630617 ]
  }, {
    "dbId" : 10648686,
    "stId" : "R-DRE-202424",
    "displayName" : "Downstream TCR signaling",
    "events" : [ 10576035, 10575227 ]
  }, {
    "dbId" : 10648720,
    "stId" : "R-DRE-202433",
    "displayName" : "Generation of second messenger molecules",
    "events" : [ 10585619, 10585625, 10576088, 10576091, 10585627, 10576076 ]
  } ]
}