{
  "dbId" : 10648596,
  "stableId" : "R-DRE-195253",
  "displayName" : "Degradation of beta-catenin by the destruction complex",
  "nodes" : [ {
    "id" : 50432,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 309,
      "y" : 1369
    },
    "minX" : 289,
    "maxX" : 359,
    "minY" : 1344,
    "maxY" : 1385,
    "prop" : {
      "x" : 289,
      "y" : 1354,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 292,
      "y" : 1359
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 324,
          "y" : 1359
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 324,
          "y" : 1359
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50430,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 332,
          "y" : 1359
        },
        "to" : {
          "x" : 359,
          "y" : 1344
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 336,
          "y" : 1352
        },
        "b" : {
          "x" : 332,
          "y" : 1359
        },
        "c" : {
          "x" : 340,
          "y" : 1359
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 340,
          "y" : 1359
        }
      }
    } ]
  }, {
    "id" : 50434,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 218,
      "y" : 885
    },
    "minX" : 199,
    "maxX" : 332,
    "minY" : 869,
    "maxY" : 901,
    "prop" : {
      "x" : 199,
      "y" : 870,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 202,
      "y" : 875
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 232,
          "y" : 875
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 232,
          "y" : 875
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50433,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 240,
          "y" : 884
        },
        "to" : {
          "x" : 332,
          "y" : 884
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50435,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 227,
      "y" : 976
    },
    "minX" : 207,
    "maxX" : 335,
    "minY" : 931,
    "maxY" : 992,
    "prop" : {
      "x" : 207,
      "y" : 961,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 210,
      "y" : 966
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 242,
          "y" : 966
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 242,
          "y" : 966
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50433,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 250,
          "y" : 967
        },
        "to" : {
          "x" : 335,
          "y" : 931
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 255,
          "y" : 961
        },
        "b" : {
          "x" : 250,
          "y" : 967
        },
        "c" : {
          "x" : 258,
          "y" : 968
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 258,
          "y" : 968
        }
      }
    } ]
  }, {
    "id" : 50437,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 211,
      "y" : 393
    },
    "minX" : 191,
    "maxX" : 323,
    "minY" : 377,
    "maxY" : 408,
    "prop" : {
      "x" : 191,
      "y" : 378,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 196,
      "y" : 382
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 227,
          "y" : 383
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 227,
          "y" : 383
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50436,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 235,
          "y" : 393
        },
        "to" : {
          "x" : 323,
          "y" : 394
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 273,
            "y" : 387
          },
          "b" : {
            "x" : 285,
            "y" : 399
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 279,
            "y" : 393
          }
        }
      }
    } ]
  }, {
    "id" : 50438,
    "reactomeId" : 10575913,
    "displayName" : "AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 325,
      "y" : 334
    },
    "minX" : 257,
    "maxX" : 399,
    "minY" : 299,
    "maxY" : 420,
    "prop" : {
      "x" : 257,
      "y" : 305,
      "width" : 136,
      "height" : 58
    },
    "textPosition" : {
      "x" : 266,
      "y" : 300
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 393,
          "y" : 305
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 393,
          "y" : 305
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50436,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 324,
          "y" : 366
        },
        "to" : {
          "x" : 323,
          "y" : 394
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50436,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 346,
          "y" : 366
        },
        "to" : {
          "x" : 383,
          "y" : 414
        }
      }, {
        "from" : {
          "x" : 383,
          "y" : 414
        },
        "to" : {
          "x" : 340,
          "y" : 415
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 336,
          "y" : 416
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 336,
          "y" : 416
        }
      }
    } ]
  }, {
    "id" : 50439,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 214,
      "y" : 466
    },
    "minX" : 194,
    "maxX" : 322,
    "minY" : 437,
    "maxY" : 481,
    "prop" : {
      "x" : 194,
      "y" : 451,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 198,
      "y" : 455
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 230,
          "y" : 456
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 230,
          "y" : 456
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50436,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 238,
          "y" : 460
        },
        "to" : {
          "x" : 322,
          "y" : 437
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 274,
            "y" : 442
          },
          "b" : {
            "x" : 286,
            "y" : 454
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 280,
            "y" : 448
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 244,
          "y" : 454
        },
        "b" : {
          "x" : 238,
          "y" : 460
        },
        "c" : {
          "x" : 246,
          "y" : 462
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 246,
          "y" : 462
        }
      }
    } ]
  }, {
    "id" : 50441,
    "reactomeId" : 10577148,
    "displayName" : "BTRC:CUL1:RBX1:SKP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 947,
      "y" : 1282
    },
    "minX" : 888,
    "maxX" : 1012,
    "minY" : 1135,
    "maxY" : 1373,
    "prop" : {
      "x" : 888,
      "y" : 1264,
      "width" : 118,
      "height" : 36
    },
    "textPosition" : {
      "x" : 890,
      "y" : 1265
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1006,
          "y" : 1264
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1006,
          "y" : 1264
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50440,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 957,
          "y" : 1303
        },
        "to" : {
          "x" : 1002,
          "y" : 1373
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50447,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 947,
          "y" : 1261
        },
        "to" : {
          "x" : 947,
          "y" : 1135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 943,
          "y" : 1254
        },
        "b" : {
          "x" : 947,
          "y" : 1261
        },
        "c" : {
          "x" : 951,
          "y" : 1254
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 951,
          "y" : 1254
        }
      }
    } ]
  }, {
    "id" : 50442,
    "reactomeId" : 10574035,
    "displayName" : "p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 879,
      "y" : 1376
    },
    "minX" : 810,
    "maxX" : 1002,
    "minY" : 1317,
    "maxY" : 1430,
    "prop" : {
      "x" : 810,
      "y" : 1323,
      "width" : 139,
      "height" : 107
    },
    "textPosition" : {
      "x" : 810,
      "y" : 1325
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 949,
          "y" : 1323
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 949,
          "y" : 1323
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50440,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 952,
          "y" : 1374
        },
        "to" : {
          "x" : 1002,
          "y" : 1373
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50443,
    "reactomeId" : 10601165,
    "displayName" : "RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1137,
      "y" : 1370
    },
    "minX" : 1076,
    "maxX" : 1204,
    "minY" : 1188,
    "maxY" : 1409,
    "prop" : {
      "x" : 1076,
      "y" : 1332,
      "width" : 122,
      "height" : 77
    },
    "textPosition" : {
      "x" : 1080,
      "y" : 1332
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1198,
          "y" : 1332
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1198,
          "y" : 1332
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50440,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50444,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1135,
          "y" : 1329
        },
        "to" : {
          "x" : 1131,
          "y" : 1188
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50445,
    "reactomeId" : 10560375,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1036,
      "y" : 1213
    },
    "minX" : 947,
    "maxX" : 1131,
    "minY" : 1135,
    "maxY" : 1225,
    "prop" : {
      "x" : 997,
      "y" : 1202,
      "width" : 78,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1023,
      "y" : 1203
    },
    "connectors" : [ {
      "edgeId" : 50444,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1081,
          "y" : 1202
        },
        "to" : {
          "x" : 1131,
          "y" : 1188
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1100,
            "y" : 1189
          },
          "b" : {
            "x" : 1112,
            "y" : 1201
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1106,
            "y" : 1195
          }
        }
      }
    }, {
      "edgeId" : 50447,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1022,
          "y" : 1196
        },
        "to" : {
          "x" : 947,
          "y" : 1135
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 978,
            "y" : 1159
          },
          "b" : {
            "x" : 990,
            "y" : 1171
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 984,
            "y" : 1165
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1014,
          "y" : 1195
        },
        "b" : {
          "x" : 1022,
          "y" : 1196
        },
        "c" : {
          "x" : 1019,
          "y" : 1189
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1019,
          "y" : 1189
        }
      }
    } ]
  }, {
    "id" : 50446,
    "reactomeId" : 10601169,
    "displayName" : "ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1129,
      "y" : 1100
    },
    "minX" : 1061,
    "maxX" : 1203,
    "minY" : 1056,
    "maxY" : 1138,
    "prop" : {
      "x" : 1061,
      "y" : 1062,
      "width" : 136,
      "height" : 76
    },
    "textPosition" : {
      "x" : 1070,
      "y" : 1061
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1197,
          "y" : 1062
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1197,
          "y" : 1062
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50444,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50447,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50448,
    "reactomeId" : 10601171,
    "displayName" : "p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 804,
      "y" : 1176
    },
    "minX" : 722,
    "maxX" : 947,
    "minY" : 1135,
    "maxY" : 1211,
    "prop" : {
      "x" : 722,
      "y" : 1141,
      "width" : 164,
      "height" : 70
    },
    "textPosition" : {
      "x" : 725,
      "y" : 1148
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 886,
          "y" : 1141
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 886,
          "y" : 1141
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50447,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 889,
          "y" : 1152
        },
        "to" : {
          "x" : 947,
          "y" : 1135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 895,
          "y" : 1146
        },
        "b" : {
          "x" : 889,
          "y" : 1152
        },
        "c" : {
          "x" : 897,
          "y" : 1154
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 897,
          "y" : 1154
        }
      }
    } ]
  }, {
    "id" : 50449,
    "reactomeId" : 10560473,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 948,
      "y" : 1033
    },
    "minX" : 887,
    "maxX" : 1016,
    "minY" : 1016,
    "maxY" : 1092,
    "prop" : {
      "x" : 887,
      "y" : 1022,
      "width" : 123,
      "height" : 22
    },
    "textPosition" : {
      "x" : 892,
      "y" : 1023
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1010,
          "y" : 1022
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1010,
          "y" : 1022
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50447,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 947,
          "y" : 1047
        },
        "to" : {
          "x" : 946,
          "y" : 1084
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 946,
          "y" : 1088
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 946,
          "y" : 1088
        }
      }
    } ]
  }, {
    "id" : 50451,
    "reactomeId" : 10609339,
    "displayName" : "TLE",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 685,
      "y" : 556
    },
    "minX" : 670,
    "maxX" : 746,
    "minY" : 545,
    "maxY" : 567,
    "prop" : {
      "x" : 670,
      "y" : 545,
      "width" : 30,
      "height" : 22
    },
    "textPosition" : {
      "x" : 670,
      "y" : 545
    },
    "connectors" : [ {
      "edgeId" : 50450,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 734,
            "y" : 552
          },
          "b" : {
            "x" : 746,
            "y" : 564
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 740,
            "y" : 558
          }
        }
      }
    } ]
  }, {
    "id" : 50452,
    "reactomeId" : 10606394,
    "displayName" : "TLE tetramer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 879,
      "y" : 562
    },
    "minX" : 831,
    "maxX" : 937,
    "minY" : 548,
    "maxY" : 606,
    "prop" : {
      "x" : 831,
      "y" : 548,
      "width" : 97,
      "height" : 29
    },
    "textPosition" : {
      "x" : 835,
      "y" : 552
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 50450,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50453,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 898,
          "y" : 583
        },
        "to" : {
          "x" : 937,
          "y" : 606
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50454,
    "reactomeId" : 10634495,
    "displayName" : "'canonical' WNT target genes:TCF/LEF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 886,
      "y" : 666
    },
    "minX" : 835,
    "maxX" : 944,
    "minY" : 606,
    "maxY" : 691,
    "prop" : {
      "x" : 835,
      "y" : 641,
      "width" : 103,
      "height" : 50
    },
    "textPosition" : {
      "x" : 837,
      "y" : 642
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 938,
          "y" : 641
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 938,
          "y" : 641
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50453,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 907,
          "y" : 638
        },
        "to" : {
          "x" : 937,
          "y" : 606
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50455,
    "reactomeId" : 10634497,
    "displayName" : "'canonical' WNT target gene:TCF/LEF:TLE tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1067,
      "y" : 605
    },
    "minX" : 1002,
    "maxX" : 1138,
    "minY" : 574,
    "maxY" : 630,
    "prop" : {
      "x" : 1002,
      "y" : 580,
      "width" : 130,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1012,
      "y" : 567
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1132,
          "y" : 580
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1132,
          "y" : 580
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50453,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50457,
    "reactomeId" : 10619010,
    "displayName" : "ZRANB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 196,
      "y" : 162
    },
    "minX" : 168,
    "maxX" : 297,
    "minY" : 129,
    "maxY" : 173,
    "prop" : {
      "x" : 168,
      "y" : 151,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 171,
      "y" : 145
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 224,
          "y" : 151
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 224,
          "y" : 151
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50456,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 227,
          "y" : 152
        },
        "to" : {
          "x" : 297,
          "y" : 129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50458,
    "reactomeId" : 10574018,
    "displayName" : "apc",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 366,
      "y" : 119
    },
    "minX" : 297,
    "maxX" : 430,
    "minY" : 92,
    "maxY" : 141,
    "prop" : {
      "x" : 308,
      "y" : 98,
      "width" : 116,
      "height" : 43
    },
    "textPosition" : {
      "x" : 350,
      "y" : 109
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 424,
          "y" : 98
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 424,
          "y" : 98
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50456,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 305,
          "y" : 127
        },
        "to" : {
          "x" : 297,
          "y" : 129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50459,
    "reactomeId" : 10620885,
    "displayName" : "ZRANB1:K63polyUb-APC",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 128,
      "y" : 58
    },
    "minX" : 63,
    "maxX" : 200,
    "minY" : 34,
    "maxY" : 76,
    "prop" : {
      "x" : 63,
      "y" : 40,
      "width" : 131,
      "height" : 36
    },
    "textPosition" : {
      "x" : 63,
      "y" : 41
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 194,
          "y" : 40
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 194,
          "y" : 40
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50456,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50411,
    "reactomeId" : 10574035,
    "displayName" : "p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 689,
      "y" : 1378
    },
    "minX" : 590,
    "maxX" : 761,
    "minY" : 1312,
    "maxY" : 1438,
    "prop" : {
      "x" : 624,
      "y" : 1318,
      "width" : 131,
      "height" : 120
    },
    "textPosition" : {
      "x" : 624,
      "y" : 1333
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 755,
          "y" : 1318
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 755,
          "y" : 1318
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50410,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50416,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 621,
          "y" : 1376
        },
        "to" : {
          "x" : 590,
          "y" : 1375
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 614,
          "y" : 1380
        },
        "b" : {
          "x" : 621,
          "y" : 1376
        },
        "c" : {
          "x" : 614,
          "y" : 1372
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 614,
          "y" : 1372
        }
      }
    } ]
  }, {
    "id" : 50413,
    "reactomeId" : 10574020,
    "displayName" : "p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 325,
      "y" : 494
    },
    "minX" : 263,
    "maxX" : 394,
    "minY" : 437,
    "maxY" : 548,
    "prop" : {
      "x" : 263,
      "y" : 459,
      "width" : 125,
      "height" : 70
    },
    "textPosition" : {
      "x" : 266,
      "y" : 466
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 388,
          "y" : 459
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 388,
          "y" : 459
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50436,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 323,
          "y" : 456
        },
        "to" : {
          "x" : 322,
          "y" : 437
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 319,
          "y" : 449
        },
        "b" : {
          "x" : 323,
          "y" : 456
        },
        "c" : {
          "x" : 327,
          "y" : 449
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 327,
          "y" : 449
        }
      }
    }, {
      "edgeId" : 50412,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 332,
          "y" : 532
        },
        "to" : {
          "x" : 336,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50414,
    "reactomeId" : 10574074,
    "displayName" : "ctnnb1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 444,
      "y" : 547
    },
    "minX" : 336,
    "maxX" : 482,
    "minY" : 528,
    "maxY" : 561,
    "prop" : {
      "x" : 413,
      "y" : 534,
      "width" : 63,
      "height" : 27
    },
    "textPosition" : {
      "x" : 418,
      "y" : 537
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 476,
          "y" : 534
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 476,
          "y" : 534
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50412,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 410,
          "y" : 547
        },
        "to" : {
          "x" : 336,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50415,
    "reactomeId" : 10574076,
    "displayName" : "CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 337,
      "y" : 634
    },
    "minX" : 274,
    "maxX" : 408,
    "minY" : 596,
    "maxY" : 732,
    "prop" : {
      "x" : 274,
      "y" : 602,
      "width" : 126,
      "height" : 64
    },
    "textPosition" : {
      "x" : 274,
      "y" : 603
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 400,
          "y" : 602
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 400,
          "y" : 602
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50412,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50426,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 338,
          "y" : 669
        },
        "to" : {
          "x" : 340,
          "y" : 704
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50426,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 363,
          "y" : 669
        },
        "to" : {
          "x" : 408,
          "y" : 721
        }
      }, {
        "from" : {
          "x" : 408,
          "y" : 721
        },
        "to" : {
          "x" : 359,
          "y" : 728
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 355,
          "y" : 728
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 355,
          "y" : 728
        }
      }
    } ]
  }, {
    "id" : 50417,
    "reactomeId" : 10574030,
    "displayName" : "p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 442,
      "y" : 1383
    },
    "minX" : 359,
    "maxX" : 565,
    "minY" : 1329,
    "maxY" : 1429,
    "prop" : {
      "x" : 381,
      "y" : 1337,
      "width" : 123,
      "height" : 92
    },
    "textPosition" : {
      "x" : 382,
      "y" : 1338
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 504,
          "y" : 1337
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 504,
          "y" : 1337
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50416,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 507,
          "y" : 1377
        },
        "to" : {
          "x" : 540,
          "y" : 1375
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50416,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 507,
          "y" : 1349
        },
        "to" : {
          "x" : 541,
          "y" : 1329
        }
      }, {
        "from" : {
          "x" : 541,
          "y" : 1329
        },
        "to" : {
          "x" : 559,
          "y" : 1361
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 561,
          "y" : 1365
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 561,
          "y" : 1365
        }
      }
    }, {
      "edgeId" : 50430,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 378,
          "y" : 1354
        },
        "to" : {
          "x" : 359,
          "y" : 1344
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 370,
          "y" : 1354
        },
        "b" : {
          "x" : 378,
          "y" : 1354
        },
        "c" : {
          "x" : 374,
          "y" : 1347
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 374,
          "y" : 1347
        }
      }
    } ]
  }, {
    "id" : 50418,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 535,
      "y" : 1419
    },
    "minX" : 513,
    "maxX" : 558,
    "minY" : 1375,
    "maxY" : 1435,
    "prop" : {
      "x" : 513,
      "y" : 1403,
      "width" : 44,
      "height" : 32
    },
    "textPosition" : {
      "x" : 519,
      "y" : 1408
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 552,
          "y" : 1408
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 552,
          "y" : 1408
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50416,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 536,
          "y" : 1400
        },
        "to" : {
          "x" : 540,
          "y" : 1375
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50419,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 588,
      "y" : 1416
    },
    "minX" : 568,
    "maxX" : 609,
    "minY" : 1375,
    "maxY" : 1432,
    "prop" : {
      "x" : 568,
      "y" : 1401,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 571,
      "y" : 1406
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 603,
          "y" : 1406
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 603,
          "y" : 1406
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50416,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 588,
          "y" : 1398
        },
        "to" : {
          "x" : 590,
          "y" : 1375
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 585,
          "y" : 1391
        },
        "b" : {
          "x" : 588,
          "y" : 1398
        },
        "c" : {
          "x" : 593,
          "y" : 1391
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 593,
          "y" : 1391
        }
      }
    } ]
  }, {
    "id" : 50421,
    "reactomeId" : 10574046,
    "displayName" : "p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 342,
      "y" : 1003
    },
    "minX" : 269,
    "maxX" : 422,
    "minY" : 931,
    "maxY" : 1101,
    "prop" : {
      "x" : 269,
      "y" : 964,
      "width" : 147,
      "height" : 78
    },
    "textPosition" : {
      "x" : 272,
      "y" : 979
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 416,
          "y" : 964
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 416,
          "y" : 964
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50433,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 338,
          "y" : 961
        },
        "to" : {
          "x" : 335,
          "y" : 931
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 333,
          "y" : 955
        },
        "b" : {
          "x" : 338,
          "y" : 961
        },
        "c" : {
          "x" : 341,
          "y" : 954
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 341,
          "y" : 954
        }
      }
    }, {
      "edgeId" : 50420,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 340,
          "y" : 1045
        },
        "to" : {
          "x" : 340,
          "y" : 1080
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50420,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 390,
          "y" : 1045
        },
        "to" : {
          "x" : 405,
          "y" : 1054
        }
      }, {
        "from" : {
          "x" : 405,
          "y" : 1054
        },
        "to" : {
          "x" : 355,
          "y" : 1095
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 352,
          "y" : 1097
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 352,
          "y" : 1097
        }
      }
    } ]
  }, {
    "id" : 50422,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 241,
      "y" : 1055
    },
    "minX" : 222,
    "maxX" : 340,
    "minY" : 1039,
    "maxY" : 1080,
    "prop" : {
      "x" : 222,
      "y" : 1040,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 225,
      "y" : 1045
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 255,
          "y" : 1045
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 255,
          "y" : 1045
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50420,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 263,
          "y" : 1059
        },
        "to" : {
          "x" : 340,
          "y" : 1080
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50423,
    "reactomeId" : 10574050,
    "displayName" : "p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 356,
      "y" : 1190
    },
    "minX" : 287,
    "maxX" : 432,
    "minY" : 1126,
    "maxY" : 1304,
    "prop" : {
      "x" : 287,
      "y" : 1143,
      "width" : 139,
      "height" : 94
    },
    "textPosition" : {
      "x" : 293,
      "y" : 1160
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 426,
          "y" : 1143
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 426,
          "y" : 1143
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50420,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 346,
          "y" : 1140
        },
        "to" : {
          "x" : 343,
          "y" : 1126
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 341,
          "y" : 1134
        },
        "b" : {
          "x" : 346,
          "y" : 1140
        },
        "c" : {
          "x" : 348,
          "y" : 1132
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 348,
          "y" : 1132
        }
      }
    }, {
      "edgeId" : 50430,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 358,
          "y" : 1240
        },
        "to" : {
          "x" : 360,
          "y" : 1283
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50430,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 384,
          "y" : 1240
        },
        "to" : {
          "x" : 397,
          "y" : 1257
        }
      }, {
        "from" : {
          "x" : 397,
          "y" : 1257
        },
        "to" : {
          "x" : 369,
          "y" : 1297
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 367,
          "y" : 1300
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 367,
          "y" : 1300
        }
      }
    } ]
  }, {
    "id" : 50424,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 270,
      "y" : 1133
    },
    "minX" : 250,
    "maxX" : 343,
    "minY" : 1117,
    "maxY" : 1149,
    "prop" : {
      "x" : 250,
      "y" : 1118,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 253,
      "y" : 1123
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 285,
          "y" : 1123
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 285,
          "y" : 1123
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50420,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 293,
          "y" : 1131
        },
        "to" : {
          "x" : 343,
          "y" : 1126
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 299,
          "y" : 1126
        },
        "b" : {
          "x" : 293,
          "y" : 1131
        },
        "c" : {
          "x" : 300,
          "y" : 1134
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 300,
          "y" : 1134
        }
      }
    } ]
  }, {
    "id" : 50425,
    "reactomeId" : 10574059,
    "displayName" : "FRAT1,2:GSK3beta",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 587,
      "y" : 1057
    },
    "minX" : 343,
    "maxX" : 654,
    "minY" : 913,
    "maxY" : 1314,
    "prop" : {
      "x" : 527,
      "y" : 1039,
      "width" : 121,
      "height" : 36
    },
    "textPosition" : {
      "x" : 553,
      "y" : 1040
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 648,
          "y" : 1039
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 648,
          "y" : 1039
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50433,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 555,
          "y" : 1036
        },
        "to" : {
          "x" : 345,
          "y" : 916
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 343,
          "y" : 919
        },
        "b" : {
          "x" : 347,
          "y" : 913
        },
        "c" : {
          "x" : 345,
          "y" : 916
        },
        "type" : "STOP",
        "centre" : {
          "x" : 345,
          "y" : 916
        }
      }
    }, {
      "edgeId" : 50420,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 524,
          "y" : 1068
        },
        "to" : {
          "x" : 352,
          "y" : 1103
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 351,
          "y" : 1099
        },
        "b" : {
          "x" : 353,
          "y" : 1107
        },
        "c" : {
          "x" : 352,
          "y" : 1103
        },
        "type" : "STOP",
        "centre" : {
          "x" : 352,
          "y" : 1103
        }
      }
    }, {
      "edgeId" : 50430,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 576,
          "y" : 1078
        },
        "to" : {
          "x" : 436,
          "y" : 1306
        }
      }, {
        "from" : {
          "x" : 436,
          "y" : 1306
        },
        "to" : {
          "x" : 369,
          "y" : 1310
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 369,
          "y" : 1306
        },
        "b" : {
          "x" : 369,
          "y" : 1314
        },
        "c" : {
          "x" : 369,
          "y" : 1310
        },
        "type" : "STOP",
        "centre" : {
          "x" : 369,
          "y" : 1310
        }
      }
    } ]
  }, {
    "id" : 50427,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 258,
      "y" : 690
    },
    "minX" : 238,
    "maxX" : 340,
    "minY" : 674,
    "maxY" : 705,
    "prop" : {
      "x" : 238,
      "y" : 675,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 242,
      "y" : 679
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 273,
          "y" : 680
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 273,
          "y" : 680
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50426,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 281,
          "y" : 693
        },
        "to" : {
          "x" : 340,
          "y" : 704
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50428,
    "reactomeId" : 10574066,
    "displayName" : "p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 339,
      "y" : 813
    },
    "minX" : 274,
    "maxX" : 411,
    "minY" : 753,
    "maxY" : 912,
    "prop" : {
      "x" : 274,
      "y" : 774,
      "width" : 131,
      "height" : 78
    },
    "textPosition" : {
      "x" : 280,
      "y" : 775
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 405,
          "y" : 774
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 405,
          "y" : 774
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50433,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 335,
          "y" : 855
        },
        "to" : {
          "x" : 332,
          "y" : 884
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50433,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 369,
          "y" : 855
        },
        "to" : {
          "x" : 398,
          "y" : 889
        }
      }, {
        "from" : {
          "x" : 398,
          "y" : 889
        },
        "to" : {
          "x" : 352,
          "y" : 906
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 348,
          "y" : 908
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 348,
          "y" : 908
        }
      }
    }, {
      "edgeId" : 50426,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 339,
          "y" : 771
        },
        "to" : {
          "x" : 339,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 335,
          "y" : 764
        },
        "b" : {
          "x" : 339,
          "y" : 771
        },
        "c" : {
          "x" : 343,
          "y" : 764
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 343,
          "y" : 764
        }
      }
    } ]
  }, {
    "id" : 50429,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 257,
      "y" : 758
    },
    "minX" : 237,
    "maxX" : 339,
    "minY" : 742,
    "maxY" : 774,
    "prop" : {
      "x" : 237,
      "y" : 743,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 240,
      "y" : 748
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 272,
          "y" : 748
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 272,
          "y" : 748
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50426,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 280,
          "y" : 756
        },
        "to" : {
          "x" : 339,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 287,
          "y" : 752
        },
        "b" : {
          "x" : 280,
          "y" : 756
        },
        "c" : {
          "x" : 287,
          "y" : 760
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 287,
          "y" : 760
        }
      }
    } ]
  }, {
    "id" : 50431,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 285,
      "y" : 1263
    },
    "minX" : 263,
    "maxX" : 360,
    "minY" : 1246,
    "maxY" : 1283,
    "prop" : {
      "x" : 263,
      "y" : 1247,
      "width" : 44,
      "height" : 32
    },
    "textPosition" : {
      "x" : 269,
      "y" : 1252
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 302,
          "y" : 1252
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 302,
          "y" : 1252
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50430,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 310,
          "y" : 1268
        },
        "to" : {
          "x" : 360,
          "y" : 1283
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 50433,
    "reactomeId" : 10574069,
    "displayName" : "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 337,
      "y" : 912
    },
    "minX" : 331,
    "maxX" : 343,
    "minY" : 884,
    "maxY" : 931,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 332,
        "y" : 884
      },
      "to" : {
        "x" : 337,
        "y" : 912
      }
    }, {
      "from" : {
        "x" : 337,
        "y" : 912
      },
      "to" : {
        "x" : 335,
        "y" : 931
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 331,
        "y" : 906
      },
      "b" : {
        "x" : 343,
        "y" : 918
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 337,
        "y" : 912
      }
    },
    "inputs" : [ {
      "id" : 50428,
      "points" : [ {
        "x" : 335,
        "y" : 855
      } ]
    }, {
      "id" : 50434,
      "points" : [ {
        "x" : 240,
        "y" : 884
      } ]
    } ],
    "outputs" : [ {
      "id" : 50421,
      "points" : [ {
        "x" : 338,
        "y" : 961
      } ]
    }, {
      "id" : 50435,
      "points" : [ {
        "x" : 250,
        "y" : 967
      } ]
    } ],
    "catalysts" : [ {
      "id" : 50428,
      "points" : [ {
        "x" : 369,
        "y" : 855
      }, {
        "x" : 398,
        "y" : 889
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 50425,
      "points" : [ {
        "x" : 555,
        "y" : 1036
      } ]
    } ]
  }, {
    "id" : 50436,
    "reactomeId" : 10611072,
    "displayName" : "AXIN is phosphorylated in the destruction complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 324,
      "y" : 416
    },
    "minX" : 318,
    "maxX" : 330,
    "minY" : 394,
    "maxY" : 437,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 323,
        "y" : 394
      },
      "to" : {
        "x" : 324,
        "y" : 416
      }
    }, {
      "from" : {
        "x" : 324,
        "y" : 416
      },
      "to" : {
        "x" : 322,
        "y" : 437
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 318,
        "y" : 410
      },
      "b" : {
        "x" : 330,
        "y" : 422
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 324,
        "y" : 416
      }
    },
    "inputs" : [ {
      "id" : 50437,
      "points" : [ {
        "x" : 235,
        "y" : 393
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 50438,
      "points" : [ {
        "x" : 324,
        "y" : 366
      } ]
    } ],
    "outputs" : [ {
      "id" : 50413,
      "points" : [ {
        "x" : 323,
        "y" : 456
      } ]
    }, {
      "id" : 50439,
      "points" : [ {
        "x" : 238,
        "y" : 460
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 50438,
      "points" : [ {
        "x" : 346,
        "y" : 366
      }, {
        "x" : 383,
        "y" : 414
      } ]
    } ]
  }, {
    "id" : 50440,
    "reactomeId" : 10601167,
    "displayName" : "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1020,
      "y" : 1374
    },
    "minX" : 1002,
    "maxX" : 1073,
    "minY" : 1368,
    "maxY" : 1380,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1002,
        "y" : 1373
      },
      "to" : {
        "x" : 1020,
        "y" : 1374
      }
    }, {
      "from" : {
        "x" : 1020,
        "y" : 1374
      },
      "to" : {
        "x" : 1073,
        "y" : 1372
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1066,
        "y" : 1376
      },
      "b" : {
        "x" : 1073,
        "y" : 1372
      },
      "c" : {
        "x" : 1066,
        "y" : 1368
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1066,
        "y" : 1368
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1020,
        "y" : 1374
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1020,
        "y" : 1374
      }
    },
    "inputs" : [ {
      "id" : 50441,
      "points" : [ {
        "x" : 957,
        "y" : 1303
      } ]
    }, {
      "id" : 50442,
      "points" : [ {
        "x" : 952,
        "y" : 1374
      } ]
    } ],
    "outputs" : [ {
      "id" : 50443
    } ]
  }, {
    "id" : 50410,
    "reactomeId" : 10574042,
    "displayName" : "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 781,
      "y" : 1378
    },
    "minX" : 758,
    "maxX" : 807,
    "minY" : 1372,
    "maxY" : 1384,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 758,
        "y" : 1378
      },
      "to" : {
        "x" : 781,
        "y" : 1378
      }
    }, {
      "from" : {
        "x" : 781,
        "y" : 1378
      },
      "to" : {
        "x" : 807,
        "y" : 1377
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 775,
        "y" : 1372
      },
      "b" : {
        "x" : 787,
        "y" : 1384
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 781,
        "y" : 1378
      }
    },
    "inputs" : [ {
      "id" : 50411
    } ]
  }, {
    "id" : 50444,
    "reactomeId" : 10601175,
    "displayName" : "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1131,
      "y" : 1165
    },
    "minX" : 1125,
    "maxX" : 1137,
    "minY" : 1141,
    "maxY" : 1188,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1131,
        "y" : 1188
      },
      "to" : {
        "x" : 1131,
        "y" : 1165
      }
    }, {
      "from" : {
        "x" : 1131,
        "y" : 1165
      },
      "to" : {
        "x" : 1130,
        "y" : 1141
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1134,
        "y" : 1148
      },
      "b" : {
        "x" : 1130,
        "y" : 1141
      },
      "c" : {
        "x" : 1126,
        "y" : 1148
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1126,
        "y" : 1148
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1131,
        "y" : 1165
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1131,
        "y" : 1165
      }
    },
    "inputs" : [ {
      "id" : 50443,
      "points" : [ {
        "x" : 1135,
        "y" : 1329
      } ]
    }, {
      "id" : 50445,
      "points" : [ {
        "x" : 1081,
        "y" : 1202
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 50446
    } ]
  }, {
    "id" : 50412,
    "reactomeId" : 10574078,
    "displayName" : "Association of beta-catenin with the destruction complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 336,
      "y" : 575
    },
    "minX" : 330,
    "maxX" : 342,
    "minY" : 548,
    "maxY" : 599,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 336,
        "y" : 548
      },
      "to" : {
        "x" : 336,
        "y" : 575
      }
    }, {
      "from" : {
        "x" : 336,
        "y" : 575
      },
      "to" : {
        "x" : 336,
        "y" : 599
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 332,
        "y" : 592
      },
      "b" : {
        "x" : 336,
        "y" : 599
      },
      "c" : {
        "x" : 340,
        "y" : 592
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 340,
        "y" : 592
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 336,
        "y" : 575
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 336,
        "y" : 575
      }
    },
    "inputs" : [ {
      "id" : 50413,
      "points" : [ {
        "x" : 332,
        "y" : 532
      } ]
    }, {
      "id" : 50414,
      "points" : [ {
        "x" : 410,
        "y" : 547
      } ]
    } ],
    "outputs" : [ {
      "id" : 50415
    } ]
  }, {
    "id" : 50447,
    "reactomeId" : 10601173,
    "displayName" : "Degradation of ubiquitinated beta catenin by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 946,
      "y" : 1100
    },
    "minX" : 940,
    "maxX" : 1058,
    "minY" : 1094,
    "maxY" : 1135,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1058,
        "y" : 1100
      },
      "to" : {
        "x" : 946,
        "y" : 1100
      }
    }, {
      "from" : {
        "x" : 946,
        "y" : 1100
      },
      "to" : {
        "x" : 947,
        "y" : 1135
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 940,
        "y" : 1094
      },
      "b" : {
        "x" : 952,
        "y" : 1106
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 946,
        "y" : 1100
      }
    },
    "inputs" : [ {
      "id" : 50446
    } ],
    "outputs" : [ {
      "id" : 50441,
      "points" : [ {
        "x" : 947,
        "y" : 1261
      } ]
    }, {
      "id" : 50448,
      "points" : [ {
        "x" : 889,
        "y" : 1152
      } ]
    }, {
      "id" : 50445,
      "points" : [ {
        "x" : 1022,
        "y" : 1196
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 50449,
      "points" : [ {
        "x" : 947,
        "y" : 1047
      } ]
    } ]
  }, {
    "id" : 50416,
    "reactomeId" : 10574040,
    "displayName" : "Phosphorylation of APC component of the destruction complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 567,
      "y" : 1375
    },
    "minX" : 540,
    "maxX" : 590,
    "minY" : 1369,
    "maxY" : 1381,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 540,
        "y" : 1375
      },
      "to" : {
        "x" : 567,
        "y" : 1375
      }
    }, {
      "from" : {
        "x" : 567,
        "y" : 1375
      },
      "to" : {
        "x" : 590,
        "y" : 1375
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 561,
        "y" : 1369
      },
      "b" : {
        "x" : 573,
        "y" : 1381
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 567,
        "y" : 1375
      }
    },
    "inputs" : [ {
      "id" : 50417,
      "points" : [ {
        "x" : 507,
        "y" : 1377
      } ]
    }, {
      "id" : 50418,
      "points" : [ {
        "x" : 536,
        "y" : 1400
      } ]
    } ],
    "outputs" : [ {
      "id" : 50411,
      "points" : [ {
        "x" : 621,
        "y" : 1376
      } ]
    }, {
      "id" : 50419,
      "points" : [ {
        "x" : 588,
        "y" : 1398
      } ]
    } ],
    "catalysts" : [ {
      "id" : 50417,
      "points" : [ {
        "x" : 507,
        "y" : 1349
      }, {
        "x" : 541,
        "y" : 1329
      } ]
    } ]
  }, {
    "id" : 50450,
    "reactomeId" : 10609341,
    "displayName" : "TLE oligomerizes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 774,
      "y" : 560
    },
    "minX" : 706,
    "maxX" : 825,
    "minY" : 554,
    "maxY" : 566,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 706,
        "y" : 556
      },
      "to" : {
        "x" : 774,
        "y" : 560
      }
    }, {
      "from" : {
        "x" : 774,
        "y" : 560
      },
      "to" : {
        "x" : 825,
        "y" : 561
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 818,
        "y" : 565
      },
      "b" : {
        "x" : 825,
        "y" : 561
      },
      "c" : {
        "x" : 818,
        "y" : 557
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 818,
        "y" : 557
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 768,
        "y" : 554
      },
      "b" : {
        "x" : 780,
        "y" : 566
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 774,
        "y" : 560
      }
    },
    "inputs" : [ {
      "id" : 50451,
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 50452
    } ]
  }, {
    "id" : 50420,
    "reactomeId" : 10574061,
    "displayName" : "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 343,
      "y" : 1105
    },
    "minX" : 337,
    "maxX" : 349,
    "minY" : 1080,
    "maxY" : 1126,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 340,
        "y" : 1080
      },
      "to" : {
        "x" : 343,
        "y" : 1105
      }
    }, {
      "from" : {
        "x" : 343,
        "y" : 1105
      },
      "to" : {
        "x" : 343,
        "y" : 1126
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 337,
        "y" : 1099
      },
      "b" : {
        "x" : 349,
        "y" : 1111
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 343,
        "y" : 1105
      }
    },
    "inputs" : [ {
      "id" : 50421,
      "points" : [ {
        "x" : 340,
        "y" : 1045
      } ]
    }, {
      "id" : 50422,
      "points" : [ {
        "x" : 263,
        "y" : 1059
      } ]
    } ],
    "outputs" : [ {
      "id" : 50423,
      "points" : [ {
        "x" : 346,
        "y" : 1140
      } ]
    }, {
      "id" : 50424,
      "points" : [ {
        "x" : 293,
        "y" : 1131
      } ]
    } ],
    "catalysts" : [ {
      "id" : 50421,
      "points" : [ {
        "x" : 390,
        "y" : 1045
      }, {
        "x" : 405,
        "y" : 1054
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 50425,
      "points" : [ {
        "x" : 524,
        "y" : 1068
      } ]
    } ]
  }, {
    "id" : 50453,
    "reactomeId" : 10634499,
    "displayName" : "TLE tetramers bind TCF/LEF at WNT promoters",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 963,
      "y" : 607
    },
    "minX" : 937,
    "maxX" : 999,
    "minY" : 601,
    "maxY" : 613,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 937,
        "y" : 606
      },
      "to" : {
        "x" : 963,
        "y" : 607
      }
    }, {
      "from" : {
        "x" : 963,
        "y" : 607
      },
      "to" : {
        "x" : 999,
        "y" : 606
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 992,
        "y" : 610
      },
      "b" : {
        "x" : 999,
        "y" : 606
      },
      "c" : {
        "x" : 992,
        "y" : 602
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 992,
        "y" : 602
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 963,
        "y" : 607
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 963,
        "y" : 607
      }
    },
    "inputs" : [ {
      "id" : 50452,
      "points" : [ {
        "x" : 898,
        "y" : 583
      } ]
    }, {
      "id" : 50454,
      "points" : [ {
        "x" : 907,
        "y" : 638
      } ]
    } ],
    "outputs" : [ {
      "id" : 50455
    } ]
  }, {
    "id" : 50456,
    "reactomeId" : 10620887,
    "displayName" : "ZRANB1 binds APC",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 252,
      "y" : 96
    },
    "minX" : 186,
    "maxX" : 297,
    "minY" : 79,
    "maxY" : 129,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 297,
        "y" : 129
      },
      "to" : {
        "x" : 252,
        "y" : 96
      }
    }, {
      "from" : {
        "x" : 252,
        "y" : 96
      },
      "to" : {
        "x" : 186,
        "y" : 79
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 194,
        "y" : 77
      },
      "b" : {
        "x" : 186,
        "y" : 79
      },
      "c" : {
        "x" : 192,
        "y" : 85
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 192,
        "y" : 85
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 252,
        "y" : 96
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 252,
        "y" : 96
      }
    },
    "inputs" : [ {
      "id" : 50457,
      "points" : [ {
        "x" : 227,
        "y" : 152
      } ]
    }, {
      "id" : 50458,
      "points" : [ {
        "x" : 305,
        "y" : 127
      } ]
    } ],
    "outputs" : [ {
      "id" : 50459
    } ]
  }, {
    "id" : 50426,
    "reactomeId" : 10574081,
    "displayName" : "Phosphorylation of beta-catenin at Ser45 by CK1 alpha",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 343,
      "y" : 730
    },
    "minX" : 337,
    "maxX" : 349,
    "minY" : 704,
    "maxY" : 753,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 340,
        "y" : 704
      },
      "to" : {
        "x" : 343,
        "y" : 730
      }
    }, {
      "from" : {
        "x" : 343,
        "y" : 730
      },
      "to" : {
        "x" : 339,
        "y" : 753
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 337,
        "y" : 724
      },
      "b" : {
        "x" : 349,
        "y" : 736
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 343,
        "y" : 730
      }
    },
    "inputs" : [ {
      "id" : 50415,
      "points" : [ {
        "x" : 338,
        "y" : 669
      } ]
    }, {
      "id" : 50427,
      "points" : [ {
        "x" : 281,
        "y" : 693
      } ]
    } ],
    "outputs" : [ {
      "id" : 50428,
      "points" : [ {
        "x" : 339,
        "y" : 771
      } ]
    }, {
      "id" : 50429,
      "points" : [ {
        "x" : 280,
        "y" : 756
      } ]
    } ],
    "catalysts" : [ {
      "id" : 50415,
      "points" : [ {
        "x" : 363,
        "y" : 669
      }, {
        "x" : 408,
        "y" : 721
      } ]
    } ]
  }, {
    "id" : 50430,
    "reactomeId" : 10574072,
    "displayName" : "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 360,
      "y" : 1310
    },
    "minX" : 354,
    "maxX" : 366,
    "minY" : 1283,
    "maxY" : 1344,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 360,
        "y" : 1283
      },
      "to" : {
        "x" : 360,
        "y" : 1310
      }
    }, {
      "from" : {
        "x" : 360,
        "y" : 1310
      },
      "to" : {
        "x" : 359,
        "y" : 1344
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 354,
        "y" : 1304
      },
      "b" : {
        "x" : 366,
        "y" : 1316
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 360,
        "y" : 1310
      }
    },
    "inputs" : [ {
      "id" : 50431,
      "points" : [ {
        "x" : 310,
        "y" : 1268
      } ]
    }, {
      "id" : 50423,
      "points" : [ {
        "x" : 358,
        "y" : 1240
      } ]
    } ],
    "outputs" : [ {
      "id" : 50432,
      "points" : [ {
        "x" : 332,
        "y" : 1359
      } ]
    }, {
      "id" : 50417,
      "points" : [ {
        "x" : 378,
        "y" : 1354
      } ]
    } ],
    "catalysts" : [ {
      "id" : 50423,
      "points" : [ {
        "x" : 384,
        "y" : 1240
      }, {
        "x" : 397,
        "y" : 1257
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 50425,
      "points" : [ {
        "x" : 576,
        "y" : 1078
      }, {
        "x" : 436,
        "y" : 1306
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 50467,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 966,
      "y" : 644
    },
    "minX" : 525,
    "maxX" : 1407,
    "minY" : 370,
    "maxY" : 919,
    "prop" : {
      "x" : 525,
      "y" : 370,
      "width" : 882,
      "height" : 549
    },
    "textPosition" : {
      "x" : 1235,
      "y" : 847
    },
    "insets" : {
      "x" : 535,
      "y" : 380,
      "width" : 862,
      "height" : 529
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 50452, 50451, 50450, 50455, 50472, 50454, 50453, 50471 ]
  }, {
    "id" : 50463,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 737,
      "y" : 731
    },
    "minX" : 0,
    "maxX" : 1474,
    "minY" : 0,
    "maxY" : 1462,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1474,
      "height" : 1462
    },
    "textPosition" : {
      "x" : 175,
      "y" : 1373
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1454,
      "height" : 1442
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 50431, 50438, 50432, 50417, 50448, 50412, 50416, 50428, 50421, 50423, 50420, 50426, 50430, 50433, 50445, 50411, 50442, 50410, 50429, 50434, 50422, 50424, 50435, 50419, 50418, 50425, 50449, 50467, 50436, 50413, 50439, 50437, 50458, 50440, 50441, 50443, 50444, 50446, 50447, 50414, 50415, 50427, 50456, 50457, 50459 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 50472,
    "reactomeId" : 10648600,
    "displayName" : "Beta-catenin phosphorylation cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 423,
      "y" : 1015
    },
    "minX" : 189,
    "maxX" : 658,
    "minY" : 592,
    "maxY" : 1439,
    "prop" : {
      "x" : 189,
      "y" : 592,
      "width" : 469,
      "height" : 847
    },
    "points" : [ {
      "x" : 189,
      "y" : 592
    }, {
      "x" : 658,
      "y" : 592
    }, {
      "x" : 658,
      "y" : 1439
    }, {
      "x" : 189,
      "y" : 1439
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 50473,
    "reactomeId" : 10649862,
    "displayName" : "Repression of WNT target genes",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 901,
      "y" : 618
    },
    "minX" : 660,
    "maxX" : 1142,
    "minY" : 535,
    "maxY" : 701,
    "prop" : {
      "x" : 660,
      "y" : 535,
      "width" : 482,
      "height" : 166
    },
    "points" : [ {
      "x" : 660,
      "y" : 535
    }, {
      "x" : 1142,
      "y" : 535
    }, {
      "x" : 1142,
      "y" : 701
    }, {
      "x" : 660,
      "y" : 701
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 1474,
  "minY" : 0,
  "maxY" : 1462,
  "disease" : false
}