{
  "dbId" : 10648296,
  "stId" : "R-DRE-975155",
  "speciesName" : "Danio rerio",
  "nodes" : [ {
    "dbId" : 10590629,
    "stId" : "R-DRE-450279",
    "displayName" : "tab2 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q5RFW2",
    "standardIdentifier" : "uniprot:Q5RFW2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "tab2" ],
    "parents" : [ 10590633 ],
    "children" : [ ]
  }, {
    "dbId" : 10590631,
    "stId" : "R-DRE-450247",
    "displayName" : "tab3 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A4IFZ0",
    "standardIdentifier" : "uniprot:A4IFZ0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "tab3" ],
    "parents" : [ 10590633 ],
    "children" : [ ]
  }, {
    "dbId" : 10590633,
    "stId" : "R-DRE-975101",
    "displayName" : "TAB2/3 [endosome membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10590645, 10590639 ],
    "children" : [ 10590631, 10590629 ]
  }, {
    "dbId" : 10590635,
    "stId" : "R-DRE-450315",
    "displayName" : "MAP3K7 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A0A8M3AT57",
    "standardIdentifier" : "uniprot:A0A8M3AT57",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10590639 ],
    "children" : [ ]
  }, {
    "dbId" : 10590637,
    "stId" : "R-DRE-450238",
    "displayName" : "Ghost homologue of TAB1 [endosome membrane]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 68323,
    "parents" : [ 10590645, 10590639 ],
    "children" : [ ]
  }, {
    "dbId" : 10590639,
    "stId" : "R-DRE-975128",
    "displayName" : "TAK1 complex [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10590641 ],
    "children" : [ 10590637, 10590635, 10590633 ]
  }, {
    "dbId" : 10590641,
    "stId" : "R-DRE-975099",
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24631 ],
    "parents" : [ ],
    "children" : [ 10590639, 10570860, 10587213 ]
  }, {
    "dbId" : 10590643,
    "stId" : "R-DRE-450332",
    "displayName" : "phospho-p-T184,T187-MAP3K7 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A0A8M3AT57",
    "standardIdentifier" : "uniprot:A0A8M3AT57",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10590645 ],
    "children" : [ ]
  }, {
    "dbId" : 10590645,
    "stId" : "R-DRE-975171",
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24634 ],
    "parents" : [ ],
    "children" : [ 10570860, 10590637, 10587213, 10590633, 10590643 ]
  }, {
    "dbId" : 10590651,
    "stId" : "R-DRE-975112",
    "displayName" : "phospho-K63polyUb-hp-IRAK1 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F6NJE2",
    "standardIdentifier" : "uniprot:F6NJE2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10590653 ],
    "children" : [ ]
  }, {
    "dbId" : 10590653,
    "stId" : "R-DRE-975172",
    "displayName" : "K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24623 ],
    "parents" : [ 10590655 ],
    "children" : [ 10587215, 10590651 ]
  }, {
    "dbId" : 10590655,
    "stId" : "R-DRE-975121",
    "displayName" : "TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24627 ],
    "parents" : [ ],
    "children" : [ 10590653, 10576097 ]
  }, {
    "dbId" : 10573582,
    "stId" : "R-DRE-168114",
    "displayName" : "ikbkb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A0A8M1NIE6",
    "standardIdentifier" : "uniprot:A0A8M1NIE6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ikbkb" ],
    "parents" : [ 10576097 ],
    "children" : [ ]
  }, {
    "dbId" : 10570517,
    "stId" : "R-DRE-450318",
    "displayName" : "phospho-irf7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 24636 ],
    "identifier" : "F1QNG2",
    "standardIdentifier" : "uniprot:F1QNG2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "irf7" ],
    "parents" : [ 10570862 ],
    "children" : [ ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 24632, 24617 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 24633, 24619 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10576097,
    "stId" : "R-DRE-168113",
    "displayName" : "CHUK:IKBKB:IKBKG [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24626 ],
    "parents" : [ 10590655 ],
    "children" : [ 10573582, 10576095, 10574416 ]
  }, {
    "dbId" : 10560353,
    "stId" : "R-DRE-939213",
    "displayName" : "UBB(77-152) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q3B7P7",
    "standardIdentifier" : "uniprot:Q3B7P7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10560375 ],
    "children" : [ ]
  }, {
    "dbId" : 10587488,
    "stId" : "R-DRE-450825",
    "displayName" : "phospho-peli2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6DHJ8",
    "standardIdentifier" : "uniprot:Q6DHJ8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "peli2" ],
    "parents" : [ 10587493 ],
    "children" : [ ]
  }, {
    "dbId" : 10587491,
    "stId" : "R-DRE-450806",
    "displayName" : "phospho-peli3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "E7F7M5",
    "standardIdentifier" : "uniprot:E7F7M5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "peli3" ],
    "parents" : [ 10587493 ],
    "children" : [ ]
  }, {
    "dbId" : 10560355,
    "stId" : "R-DRE-939230",
    "displayName" : "UBB(153-228) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q3B7P7",
    "standardIdentifier" : "uniprot:Q3B7P7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10560375 ],
    "children" : [ ]
  }, {
    "dbId" : 10587493,
    "stId" : "R-DRE-450819",
    "displayName" : "p-Pellino-1,2,(3) [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "diagramIds" : [ 24624, 24610 ],
    "parents" : [ 10590663 ],
    "children" : [ 10587485, 10587488, 10587491 ]
  }, {
    "dbId" : 10576101,
    "stId" : "R-DRE-206072",
    "displayName" : "ube2nb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7T3F3",
    "standardIdentifier" : "uniprot:Q7T3F3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ube2nb" ],
    "parents" : [ 10576105 ],
    "children" : [ ]
  }, {
    "dbId" : 10560357,
    "stId" : "R-DRE-939188",
    "displayName" : "ubb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A0A0N4SUD2",
    "standardIdentifier" : "uniprot:A0A0N4SUD2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ubb" ],
    "parents" : [ 10560375 ],
    "children" : [ ]
  }, {
    "dbId" : 10576103,
    "stId" : "R-DRE-206072-2",
    "displayName" : "ube2na [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q803J2",
    "standardIdentifier" : "uniprot:Q803J2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ube2na" ],
    "parents" : [ 10576105 ],
    "children" : [ ]
  }, {
    "dbId" : 10576105,
    "stId" : "R-DRE-206072-3",
    "displayName" : "Homologues of UBE2N [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10576111 ],
    "children" : [ 10576103, 10576101 ]
  }, {
    "dbId" : 10570858,
    "stId" : "R-DRE-450143",
    "displayName" : "K63-Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10570860 ],
    "children" : [ 10570829, 10570826, 10570823, 10570820, 10570832, 10570817 ]
  }, {
    "dbId" : 10576109,
    "stId" : "R-DRE-205753",
    "displayName" : "ube2v1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q3B7F0",
    "standardIdentifier" : "uniprot:Q3B7F0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ube2v1" ],
    "parents" : [ 10576111 ],
    "children" : [ ]
  }, {
    "dbId" : 10570860,
    "stId" : "R-DRE-450152",
    "displayName" : "K63polyUb [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 68323,
    "diagramIds" : [ 24606, 24622 ],
    "parents" : [ 10590645, 10590641 ],
    "children" : [ 10570858 ]
  }, {
    "dbId" : 10576111,
    "stId" : "R-DRE-202463",
    "displayName" : "UBE2N:UBE2V1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24621 ],
    "parents" : [ ],
    "children" : [ 10576109, 10576105 ]
  }, {
    "dbId" : 10570862,
    "stId" : "R-DRE-450344",
    "displayName" : "p-2S-IRF7:p-2S-IRF7 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24637 ],
    "parents" : [ ],
    "children" : [ 10570517 ]
  }, {
    "dbId" : 10560375,
    "stId" : "R-DRE-113595",
    "displayName" : "Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "diagramIds" : [ 24605 ],
    "parents" : [ ],
    "children" : [ 10560353, 10560355, 10560357, 10560347, 10560349, 10560351 ]
  }, {
    "dbId" : 10573566,
    "stId" : "R-DRE-166366",
    "displayName" : "TRAF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 24614 ],
    "identifier" : "Q6IWL4",
    "standardIdentifier" : "uniprot:Q6IWL4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10570817,
    "stId" : "R-DRE-939248",
    "displayName" : "rps27a [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7SXA3",
    "standardIdentifier" : "uniprot:Q7SXA3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "rps27a" ],
    "parents" : [ 10570858 ],
    "children" : [ ]
  }, {
    "dbId" : 10590659,
    "stId" : "R-DRE-975157",
    "displayName" : "phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F6NJE2",
    "standardIdentifier" : "uniprot:F6NJE2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10590661 ],
    "children" : [ ]
  }, {
    "dbId" : 10590661,
    "stId" : "R-DRE-975150",
    "displayName" : "TRAF6:hp-IRAK1 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24609 ],
    "parents" : [ 10590663 ],
    "children" : [ 10587215, 10590659 ]
  }, {
    "dbId" : 10570820,
    "stId" : "R-DRE-939169",
    "displayName" : "ubc [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F1QHN6",
    "standardIdentifier" : "uniprot:F1QHN6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ubc" ],
    "parents" : [ 10570858 ],
    "children" : [ ]
  }, {
    "dbId" : 10590663,
    "stId" : "R-DRE-975166",
    "displayName" : "p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24611, 24618 ],
    "parents" : [ ],
    "children" : [ 10590661, 10587493 ]
  }, {
    "dbId" : 10570823,
    "stId" : "R-DRE-939224",
    "displayName" : "Ub-63-UBB(1-76) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q3B7P7",
    "standardIdentifier" : "uniprot:Q3B7P7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10570858 ],
    "children" : [ ]
  }, {
    "dbId" : 10572230,
    "stId" : "R-DRE-450270",
    "displayName" : "phospho-irf7 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F1QNG2",
    "standardIdentifier" : "uniprot:F1QNG2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "irf7" ],
    "parents" : [ 10572232 ],
    "children" : [ ]
  }, {
    "dbId" : 10587209,
    "stId" : "R-DRE-450227",
    "displayName" : "K63polyUb-TRAF6 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6IWL4",
    "standardIdentifier" : "uniprot:Q6IWL4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10587213 ],
    "children" : [ ]
  }, {
    "dbId" : 10572232,
    "stId" : "R-DRE-450306",
    "displayName" : "2xp-S477,S479-IRF7 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24639 ],
    "parents" : [ ],
    "children" : [ 10572230 ]
  }, {
    "dbId" : 10587211,
    "stId" : "R-DRE-975187",
    "displayName" : "phospho-p-IRAK2 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F6NJE2",
    "standardIdentifier" : "uniprot:F6NJE2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10590673, 10587213 ],
    "children" : [ ]
  }, {
    "dbId" : 10570826,
    "stId" : "R-DRE-939235",
    "displayName" : "Ub-139-UBB(77-152) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q3B7P7",
    "standardIdentifier" : "uniprot:Q3B7P7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10570858 ],
    "children" : [ ]
  }, {
    "dbId" : 10648270,
    "stId" : "R-DRE-450294",
    "displayName" : "MAP kinase activation",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 24663 ]
  }, {
    "dbId" : 10570829,
    "stId" : "R-DRE-939168",
    "displayName" : "Ub-215-UBB(153-228) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q3B7P7",
    "standardIdentifier" : "uniprot:Q3B7P7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10570858 ],
    "children" : [ ]
  }, {
    "dbId" : 10587213,
    "stId" : "R-DRE-975164",
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24629, 24607 ],
    "parents" : [ 10590645, 10590641 ],
    "children" : [ 10587211, 10587209 ]
  }, {
    "dbId" : 10649932,
    "stId" : "R-DRE-445989",
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation  ",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 24662 ]
  }, {
    "dbId" : 10587215,
    "stId" : "R-DRE-450272",
    "displayName" : "TRAF6 [endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6IWL4",
    "standardIdentifier" : "uniprot:Q6IWL4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10590661, 10590653, 10590675, 10590673 ],
    "children" : [ ]
  }, {
    "dbId" : 10590673,
    "stId" : "R-DRE-975108",
    "displayName" : "TRAF6:p-IRAK2 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24613 ],
    "parents" : [ 10590675 ],
    "children" : [ 10587215, 10587211 ]
  }, {
    "dbId" : 10574416,
    "stId" : "R-DRE-168104",
    "displayName" : "CHUK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q4G3H4",
    "standardIdentifier" : "uniprot:Q4G3H4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10576097 ],
    "children" : [ ]
  }, {
    "dbId" : 10570832,
    "stId" : "R-DRE-939176",
    "displayName" : "ubb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A0A0N4SUD2",
    "standardIdentifier" : "uniprot:A0A0N4SUD2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ubb" ],
    "parents" : [ 10570858 ],
    "children" : [ ]
  }, {
    "dbId" : 10590675,
    "stId" : "R-DRE-975137",
    "displayName" : "p-IRAK2:oligo-TRAF6 [endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 24615 ],
    "parents" : [ ],
    "children" : [ 10587215, 10590673 ]
  }, {
    "dbId" : 10560347,
    "stId" : "R-DRE-939205",
    "displayName" : "rps27a [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7SXA3",
    "standardIdentifier" : "uniprot:Q7SXA3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "rps27a" ],
    "parents" : [ 10560375 ],
    "children" : [ ]
  }, {
    "dbId" : 10587485,
    "stId" : "R-DRE-450815",
    "displayName" : "phospho-peli1b [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A4QN36",
    "standardIdentifier" : "uniprot:A4QN36",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "peli1b" ],
    "parents" : [ 10587493 ],
    "children" : [ ]
  }, {
    "dbId" : 10560349,
    "stId" : "R-DRE-939203",
    "displayName" : "ubc [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F1QHN6",
    "standardIdentifier" : "uniprot:F1QHN6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ubc" ],
    "parents" : [ 10560375 ],
    "children" : [ ]
  }, {
    "dbId" : 10576095,
    "stId" : "R-DRE-168108",
    "displayName" : "ikbkg [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F1QHG7",
    "standardIdentifier" : "uniprot:F1QHG7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ikbkg" ],
    "parents" : [ 10576097 ],
    "children" : [ ]
  }, {
    "dbId" : 10560351,
    "stId" : "R-DRE-939214",
    "displayName" : "UBB(1-76) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q3B7P7",
    "standardIdentifier" : "uniprot:Q3B7P7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10560375 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10590657,
    "stId" : "R-DRE-975119",
    "displayName" : "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10590666 ],
    "inputs" : [ 10590653, 10576097 ],
    "outputs" : [ 10590655 ],
    "efs" : [ ],
    "diagramIds" : [ 24625 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10587218,
    "stId" : "R-DRE-450358",
    "displayName" : "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ",
    "schemaClass" : "Polymerisation",
    "speciesId" : 0,
    "preceding" : [ 10590678 ],
    "inputs" : [ 10560375 ],
    "outputs" : [ 10570860 ],
    "catalysts" : [ 10587213 ],
    "efs" : [ ],
    "diagramIds" : [ 24604 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10590647,
    "stId" : "R-DRE-975103",
    "displayName" : "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113592, 10590641 ],
    "outputs" : [ 29370, 10590645 ],
    "efs" : [ ],
    "diagramIds" : [ 24630 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10590678,
    "stId" : "R-DRE-975147",
    "displayName" : "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10590680 ],
    "following" : [ 10587218 ],
    "inputs" : [ 10560375, 10590675 ],
    "outputs" : [ 10587213 ],
    "catalysts" : [ 10590675 ],
    "efs" : [ ],
    "diagramIds" : [ 24628 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10590680,
    "stId" : "R-DRE-975185",
    "displayName" : "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10590678 ],
    "inputs" : [ 10573566, 10590673 ],
    "outputs" : [ 10590675 ],
    "efs" : [ ],
    "diagramIds" : [ 24612 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10590666,
    "stId" : "R-DRE-975122",
    "displayName" : "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10590669 ],
    "following" : [ 10590657 ],
    "inputs" : [ 10576111, 10570860, 10590663 ],
    "outputs" : [ 10576111, 10590653, 10587493 ],
    "catalysts" : [ 10590663 ],
    "efs" : [ ],
    "diagramIds" : [ 24620 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10590669,
    "stId" : "R-DRE-975139",
    "displayName" : "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation ",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10590671 ],
    "following" : [ 10590666 ],
    "inputs" : [ 113592, 10590663 ],
    "outputs" : [ 29370, 10590663 ],
    "catalysts" : [ 10590663 ],
    "efs" : [ ],
    "diagramIds" : [ 24616 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10590316,
    "stId" : "R-DRE-933531",
    "displayName" : "Translocation of p-IRF7:p-IRF7 to nucleus",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10590318 ],
    "inputs" : [ 10570862 ],
    "outputs" : [ 10572232 ],
    "efs" : [ ],
    "diagramIds" : [ 24638 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10590671,
    "stId" : "R-DRE-975142",
    "displayName" : "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10590669 ],
    "inputs" : [ 10590661, 10587493 ],
    "outputs" : [ 10590663 ],
    "efs" : [ ],
    "diagramIds" : [ 24608 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10590318,
    "stId" : "R-DRE-933533",
    "displayName" : "Dimerization of p-IRF7",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10590316 ],
    "inputs" : [ 10570517 ],
    "outputs" : [ 10570862 ],
    "efs" : [ ],
    "diagramIds" : [ 24635 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10649210,
    "stId" : "R-DRE-975163",
    "displayName" : "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation",
    "events" : [ 10587218, 10590647, 10590678, 10590680 ]
  }, {
    "dbId" : 10649304,
    "stId" : "R-DRE-975110",
    "displayName" : "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling",
    "events" : [ 10590316, 10590318 ]
  }, {
    "dbId" : 10648294,
    "stId" : "R-DRE-975138",
    "displayName" : "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation",
    "events" : [ 10590657, 10590666, 10590669, 10590671, 10587218, 10590647, 10590678, 10590680 ]
  }, {
    "dbId" : 10649334,
    "stId" : "R-DRE-975144",
    "displayName" : "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation",
    "events" : [ 10590657, 10590666, 10590669, 10590671 ]
  } ]
}