{ "dbId" : 10648206, "stableId" : "R-DRE-157579", "displayName" : "Telomere Maintenance", "nodes" : [ { "id" : 37192, "reactomeId" : 10607767, "displayName" : "Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1626, "y" : 839 }, "minX" : 1560, "maxX" : 1698, "minY" : 772, "maxY" : 901, "prop" : { "x" : 1560, "y" : 778, "width" : 132, "height" : 123 }, "textPosition" : { "x" : 1563, "y" : 768 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1692, "y" : 778 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1692, "y" : 778 } } }, "connectors" : [ ] }, { "id" : 37134, "reactomeId" : 29892, "displayName" : "dGTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 840, "y" : 288 }, "minX" : 705, "maxX" : 937, "minY" : 274, "maxY" : 521, "prop" : { "x" : 817, "y" : 275, "width" : 47, "height" : 27 }, "textPosition" : { "x" : 820, "y" : 278 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 859, "y" : 280 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 859, "y" : 280 } } }, "connectors" : [ { "edgeId" : 37140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 840, "y" : 305 }, "to" : { "x" : 843, "y" : 521 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37133, "type" : "INPUT", "segments" : [ { "from" : { "x" : 821, "y" : 305 }, "to" : { "x" : 773, "y" : 336 } }, { "from" : { "x" : 773, "y" : 336 }, "to" : { "x" : 705, "y" : 350 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37151, "type" : "INPUT", "segments" : [ { "from" : { "x" : 858, "y" : 305 }, "to" : { "x" : 937, "y" : 357 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37135, "reactomeId" : 10569488, "displayName" : "Telomerase RNP Bound and base-paired to the Telomeric Chromosome End", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 713, "y" : 288 }, "minX" : 649, "maxX" : 783, "minY" : 243, "maxY" : 389, "prop" : { "x" : 649, "y" : 249, "width" : 128, "height" : 78 }, "textPosition" : { "x" : 654, "y" : 250 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 777, "y" : 249 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 777, "y" : 249 } } }, "connectors" : [ { "edgeId" : 37144, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37133, "type" : "INPUT", "segments" : [ { "from" : { "x" : 707, "y" : 330 }, "to" : { "x" : 705, "y" : 350 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37133, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 685, "y" : 330 }, "to" : { "x" : 663, "y" : 360 } }, { "from" : { "x" : 663, "y" : 360 }, "to" : { "x" : 692, "y" : 383 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 695, "y" : 385 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 695, "y" : 385 } } } ] }, { "id" : 37136, "reactomeId" : 30187, "displayName" : "dTTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 814, "y" : 338 }, "minX" : 705, "maxX" : 937, "minY" : 324, "maxY" : 521, "prop" : { "x" : 790, "y" : 325, "width" : 48, "height" : 26 }, "textPosition" : { "x" : 795, "y" : 327 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 833, "y" : 330 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 833, "y" : 330 } } }, "connectors" : [ { "edgeId" : 37140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 816, "y" : 354 }, "to" : { "x" : 843, "y" : 521 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37133, "type" : "INPUT", "segments" : [ { "from" : { "x" : 787, "y" : 340 }, "to" : { "x" : 705, "y" : 350 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37151, "type" : "INPUT", "segments" : [ { "from" : { "x" : 841, "y" : 341 }, "to" : { "x" : 937, "y" : 357 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37137, "reactomeId" : 29604, "displayName" : "dATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 760, "y" : 411 }, "minX" : 705, "maxX" : 937, "minY" : 350, "maxY" : 521, "prop" : { "x" : 737, "y" : 396, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 740, "y" : 400 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 778, "y" : 401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 778, "y" : 401 } } }, "connectors" : [ { "edgeId" : 37140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 771, "y" : 429 }, "to" : { "x" : 843, "y" : 521 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37133, "type" : "INPUT", "segments" : [ { "from" : { "x" : 746, "y" : 393 }, "to" : { "x" : 705, "y" : 350 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37151, "type" : "INPUT", "segments" : [ { "from" : { "x" : 786, "y" : 403 }, "to" : { "x" : 937, "y" : 357 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37138, "reactomeId" : 30185, "displayName" : "dCTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 789, "y" : 373 }, "minX" : 705, "maxX" : 937, "minY" : 350, "maxY" : 521, "prop" : { "x" : 766, "y" : 360, "width" : 46, "height" : 27 }, "textPosition" : { "x" : 769, "y" : 363 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 807, "y" : 365 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 807, "y" : 365 } } }, "connectors" : [ { "edgeId" : 37140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 793, "y" : 390 }, "to" : { "x" : 843, "y" : 521 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37133, "type" : "INPUT", "segments" : [ { "from" : { "x" : 763, "y" : 366 }, "to" : { "x" : 705, "y" : 350 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37151, "type" : "INPUT", "segments" : [ { "from" : { "x" : 815, "y" : 370 }, "to" : { "x" : 937, "y" : 357 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37139, "reactomeId" : 10569490, "displayName" : "Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 691, "y" : 498 }, "minX" : 605, "maxX" : 784, "minY" : 459, "maxY" : 532, "prop" : { "x" : 605, "y" : 465, "width" : 173, "height" : 67 }, "textPosition" : { "x" : 605, "y" : 455 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 778, "y" : 465 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 778, "y" : 465 } } }, "connectors" : [ { "edgeId" : 37143, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37133, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37204, "reactomeId" : 10571797, "displayName" : "CTF18-RFC(7s) complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1217, "y" : 262 }, "minX" : 1169, "maxX" : 1271, "minY" : 238, "maxY" : 280, "prop" : { "x" : 1169, "y" : 244, "width" : 96, "height" : 36 }, "textPosition" : { "x" : 1173, "y" : 245 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1265, "y" : 244 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1265, "y" : 244 } } }, "connectors" : [ ] }, { "id" : 37141, "reactomeId" : 10569490, "displayName" : "Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 683, "y" : 655 }, "minX" : 596, "maxX" : 847, "minY" : 521, "maxY" : 695, "prop" : { "x" : 596, "y" : 616, "width" : 174, "height" : 79 }, "textPosition" : { "x" : 594, "y" : 632 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 770, "y" : 616 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 770, "y" : 616 } } }, "connectors" : [ { "edgeId" : 37140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 730, "y" : 613 }, "to" : { "x" : 843, "y" : 521 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37140, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 754, "y" : 613 }, "to" : { "x" : 840, "y" : 568 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 843, "y" : 567 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 843, "y" : 567 } } }, { "edgeId" : 37143, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37205, "reactomeId" : 10571799, "displayName" : "RFC,(CFT18-RFC)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1228, "y" : 409 }, "minX" : 1173, "maxX" : 1283, "minY" : 396, "maxY" : 423, "prop" : { "x" : 1173, "y" : 396, "width" : 110, "height" : 27 }, "textPosition" : { "x" : 1173, "y" : 399 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ ] }, { "id" : 37142, "reactomeId" : 10569501, "displayName" : "Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 876, "y" : 644 }, "minX" : 814, "maxX" : 945, "minY" : 592, "maxY" : 691, "prop" : { "x" : 814, "y" : 598, "width" : 125, "height" : 93 }, "textPosition" : { "x" : 812, "y" : 586 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 939, "y" : 598 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 939, "y" : 598 } } }, "connectors" : [ { "edgeId" : 37140, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37145, "reactomeId" : 10569497, "displayName" : "Telomerase RNP:G-strand telomeric chromosome end", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 511, "y" : 280 }, "minX" : 457, "maxX" : 571, "minY" : 243, "maxY" : 312, "prop" : { "x" : 457, "y" : 249, "width" : 108, "height" : 63 }, "textPosition" : { "x" : 463, "y" : 235 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 565, "y" : 249 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 565, "y" : 249 } } }, "connectors" : [ { "edgeId" : 37144, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37147, "reactomeId" : 9757634, "displayName" : "NTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 889, "y" : 243 }, "minX" : 869, "maxX" : 911, "minY" : 199, "maxY" : 259, "prop" : { "x" : 869, "y" : 228, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 873, "y" : 233 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 905, "y" : 233 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 905, "y" : 233 } } }, "connectors" : [ { "edgeId" : 37146, "type" : "INPUT", "segments" : [ { "from" : { "x" : 892, "y" : 225 }, "to" : { "x" : 899, "y" : 199 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37212, "reactomeId" : 10647478, "displayName" : "DNA Damage/Telomere Stress Induced Senescence", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1701, "y" : 1206 }, "minX" : 1631, "maxX" : 1771, "minY" : 1164, "maxY" : 1249, "prop" : { "x" : 1631, "y" : 1164, "width" : 140, "height" : 85 }, "textPosition" : { "x" : 1634, "y" : 1171 }, "connectors" : [ ] }, { "id" : 37148, "reactomeId" : 10571764, "displayName" : "POLA:primase:G-strand extended telomere end", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 787, "y" : 201 }, "minX" : 730, "maxX" : 934, "minY" : 151, "maxY" : 233, "prop" : { "x" : 730, "y" : 169, "width" : 115, "height" : 64 }, "textPosition" : { "x" : 730, "y" : 184 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 845, "y" : 169 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 845, "y" : 169 } } }, "connectors" : [ { "edgeId" : 37146, "type" : "INPUT", "segments" : [ { "from" : { "x" : 848, "y" : 199 }, "to" : { "x" : 899, "y" : 199 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37146, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 848, "y" : 171 }, "to" : { "x" : 884, "y" : 151 } }, { "from" : { "x" : 884, "y" : 151 }, "to" : { "x" : 927, "y" : 189 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 930, "y" : 192 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 930, "y" : 192 } } } ] }, { "id" : 37149, "reactomeId" : 10571766, "displayName" : "RNA primer:G-strand extended telomere end:POLA:primase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1029, "y" : 251 }, "minX" : 937, "maxX" : 1102, "minY" : 218, "maxY" : 382, "prop" : { "x" : 962, "y" : 224, "width" : 134, "height" : 54 }, "textPosition" : { "x" : 963, "y" : 215 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1096, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1096, "y" : 224 } } }, "connectors" : [ { "edgeId" : 37146, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37151, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1005, "y" : 281 }, "to" : { "x" : 937, "y" : 357 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37151, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1015, "y" : 281 }, "to" : { "x" : 968, "y" : 375 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 966, "y" : 378 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 966, "y" : 378 } } } ] }, { "id" : 37150, "reactomeId" : 10571762, "displayName" : "CST complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 346, "y" : 67 }, "minX" : 295, "maxX" : 943, "minY" : 25, "maxY" : 191, "prop" : { "x" : 295, "y" : 55, "width" : 102, "height" : 24 }, "textPosition" : { "x" : 303, "y" : 58 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 397, "y" : 55 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 397, "y" : 55 } } }, "connectors" : [ { "edgeId" : 37157, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 37146, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 365, "y" : 52 }, "to" : { "x" : 413, "y" : 25 } }, { "from" : { "x" : 413, "y" : 25 }, "to" : { "x" : 939, "y" : 50 } }, { "from" : { "x" : 939, "y" : 50 }, "to" : { "x" : 939, "y" : 191 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 935, "y" : 184 }, "b" : { "x" : 939, "y" : 191 }, "c" : { "x" : 943, "y" : 184 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 943, "y" : 184 } } } ] }, { "id" : 37152, "reactomeId" : 10571772, "displayName" : "RNA primer:DNA primer:G-strand extended telomere:POLA:primase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1026, "y" : 473 }, "minX" : 962, "maxX" : 1096, "minY" : 428, "maxY" : 512, "prop" : { "x" : 962, "y" : 434, "width" : 128, "height" : 78 }, "textPosition" : { "x" : 970, "y" : 435 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1090, "y" : 434 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1090, "y" : 434 } } }, "connectors" : [ { "edgeId" : 37151, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37154, "reactomeId" : 10560640, "displayName" : "dna2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 960, "y" : 1242 }, "minX" : 938, "maxX" : 989, "minY" : 1165, "maxY" : 1253, "prop" : { "x" : 938, "y" : 1231, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 940, "y" : 1231 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 983, "y" : 1231 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 983, "y" : 1231 } } }, "connectors" : [ { "edgeId" : 37153, "type" : "INPUT", "segments" : [ { "from" : { "x" : 959, "y" : 1228 }, "to" : { "x" : 958, "y" : 1165 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37155, "reactomeId" : 10571779, "displayName" : "Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 954, "y" : 1076 }, "minX" : 888, "maxX" : 1027, "minY" : 1029, "maxY" : 1165, "prop" : { "x" : 888, "y" : 1035, "width" : 133, "height" : 82 }, "textPosition" : { "x" : 888, "y" : 1040 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1021, "y" : 1035 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1021, "y" : 1035 } } }, "connectors" : [ { "edgeId" : 37153, "type" : "INPUT", "segments" : [ { "from" : { "x" : 955, "y" : 1120 }, "to" : { "x" : 958, "y" : 1165 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37156, "reactomeId" : 10571781, "displayName" : "Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1130, "y" : 1077 }, "minX" : 1064, "maxX" : 1203, "minY" : 1031, "maxY" : 1118, "prop" : { "x" : 1064, "y" : 1037, "width" : 133, "height" : 81 }, "textPosition" : { "x" : 1064, "y" : 1041 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1197, "y" : 1037 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1197, "y" : 1037 } } }, "connectors" : [ { "edgeId" : 37153, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37158, "reactomeId" : 10571756, "displayName" : "stn1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 93, "y" : 79 }, "minX" : 71, "maxX" : 196, "minY" : 62, "maxY" : 90, "prop" : { "x" : 71, "y" : 68, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 75, "y" : 68 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 116, "y" : 68 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 116, "y" : 68 } } }, "connectors" : [ { "edgeId" : 37157, "type" : "INPUT", "segments" : [ { "from" : { "x" : 119, "y" : 76 }, "to" : { "x" : 196, "y" : 68 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37159, "reactomeId" : 10571760, "displayName" : "ten1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 141, "y" : 37 }, "minX" : 119, "maxX" : 196, "minY" : 20, "maxY" : 68, "prop" : { "x" : 119, "y" : 26, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 123, "y" : 26 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 164, "y" : 26 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 164, "y" : 26 } } }, "connectors" : [ { "edgeId" : 37157, "type" : "INPUT", "segments" : [ { "from" : { "x" : 160, "y" : 51 }, "to" : { "x" : 196, "y" : 68 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37160, "reactomeId" : 10571752, "displayName" : "ctc1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 92, "y" : 120 }, "minX" : 70, "maxX" : 196, "minY" : 68, "maxY" : 131, "prop" : { "x" : 70, "y" : 109, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 75, "y" : 109 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 115, "y" : 109 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 115, "y" : 109 } } }, "connectors" : [ { "edgeId" : 37157, "type" : "INPUT", "segments" : [ { "from" : { "x" : 114, "y" : 106 }, "to" : { "x" : 196, "y" : 68 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37162, "reactomeId" : 10571789, "displayName" : "chtf8", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1200, "y" : 167 }, "minX" : 1173, "maxX" : 1280, "minY" : 150, "maxY" : 178, "prop" : { "x" : 1173, "y" : 156, "width" : 55, "height" : 22 }, "textPosition" : { "x" : 1180, "y" : 156 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1228, "y" : 156 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1228, "y" : 156 } } }, "connectors" : [ { "edgeId" : 37161, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1231, "y" : 165 }, "to" : { "x" : 1280, "y" : 163 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37163, "reactomeId" : 10571785, "displayName" : "chtf18", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1218, "y" : 125 }, "minX" : 1186, "maxX" : 1280, "minY" : 108, "maxY" : 163, "prop" : { "x" : 1186, "y" : 114, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 1194, "y" : 114 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1250, "y" : 114 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1250, "y" : 114 } } }, "connectors" : [ { "edgeId" : 37161, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1235, "y" : 139 }, "to" : { "x" : 1280, "y" : 163 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37164, "reactomeId" : 10571793, "displayName" : "dscc1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1293, "y" : 114 }, "minX" : 1266, "maxX" : 1327, "minY" : 97, "maxY" : 163, "prop" : { "x" : 1266, "y" : 103, "width" : 55, "height" : 22 }, "textPosition" : { "x" : 1271, "y" : 103 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1321, "y" : 103 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1321, "y" : 103 } } }, "connectors" : [ { "edgeId" : 37161, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1290, "y" : 128 }, "to" : { "x" : 1280, "y" : 163 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37165, "reactomeId" : 10571795, "displayName" : "CTF18 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1403, "y" : 172 }, "minX" : 1341, "maxX" : 1471, "minY" : 155, "maxY" : 183, "prop" : { "x" : 1341, "y" : 161, "width" : 124, "height" : 22 }, "textPosition" : { "x" : 1352, "y" : 162 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1465, "y" : 161 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1465, "y" : 161 } } }, "connectors" : [ { "edgeId" : 37161, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37167, "reactomeId" : 10569438, "displayName" : "dkc1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 89, "y" : 428 }, "minX" : 67, "maxX" : 154, "minY" : 411, "maxY" : 735, "prop" : { "x" : 67, "y" : 417, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 70, "y" : 417 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 112, "y" : 417 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 112, "y" : 417 } } }, "connectors" : [ { "edgeId" : 37166, "type" : "INPUT", "segments" : [ { "from" : { "x" : 91, "y" : 442 }, "to" : { "x" : 154, "y" : 735 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37168, "reactomeId" : 10640132, "displayName" : "shq1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 152, "y" : 821 }, "minX" : 128, "maxX" : 182, "minY" : 735, "maxY" : 832, "prop" : { "x" : 128, "y" : 810, "width" : 48, "height" : 22 }, "textPosition" : { "x" : 132, "y" : 810 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 176, "y" : 810 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 176, "y" : 810 } } }, "connectors" : [ { "edgeId" : 37166, "type" : "INPUT", "segments" : [ { "from" : { "x" : 152, "y" : 807 }, "to" : { "x" : 154, "y" : 735 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 37169, "reactomeId" : 10640134, "displayName" : "DKC1:SHQ1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 287, "y" : 699 }, "minX" : 244, "maxX" : 336, "minY" : 682, "maxY" : 710, "prop" : { "x" : 244, "y" : 688, "width" : 86, "height" : 22 }, "textPosition" : { "x" : 248, "y" : 689 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 330, "y" : 688 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 330, "y" : 688 } } }, "connectors" : [ { "edgeId" : 37166, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 37153, "reactomeId" : 10571805, "displayName" : "Recruitment of DNA2 endonuclease to the C strand", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1032, "y" : 1149 }, "minX" : 958, "maxX" : 1074, "minY" : 1121, "maxY" : 1165, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 958, "y" : 1165 }, "to" : { "x" : 1032, "y" : 1149 } }, { "from" : { "x" : 1032, "y" : 1149 }, "to" : { "x" : 1074, "y" : 1121 } } ], "endShape" : { "a" : { "x" : 1070, "y" : 1128 }, "b" : { "x" : 1074, "y" : 1121 }, "c" : { "x" : 1066, "y" : 1122 }, "type" : "ARROW", "centre" : { "x" : 1066, "y" : 1122 } }, "reactionShape" : { "c" : { "x" : 1032, "y" : 1149 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1032, "y" : 1149 } }, "inputs" : [ { "id" : 37154, "points" : [ { "x" : 959, "y" : 1228 } ] }, { "id" : 37155, "points" : [ { "x" : 955, "y" : 1120 } ] } ], "outputs" : [ { "id" : 37156 } ] }, { "id" : 37140, "reactomeId" : 10570079, "displayName" : "Elongation of Extended Telomeric Chromosome End", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 854, "y" : 561 }, "minX" : 843, "maxX" : 863, "minY" : 521, "maxY" : 595, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 843, "y" : 521 }, "to" : { "x" : 854, "y" : 561 } }, { "from" : { "x" : 854, "y" : 561 }, "to" : { "x" : 863, "y" : 595 } } ], "endShape" : { "a" : { "x" : 857, "y" : 589 }, "b" : { "x" : 863, "y" : 595 }, "c" : { "x" : 865, "y" : 587 }, "type" : "ARROW", "centre" : { "x" : 865, "y" : 587 } }, "reactionShape" : { "a" : { "x" : 848, "y" : 555 }, "b" : { "x" : 860, "y" : 567 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 854, "y" : 561 } }, "inputs" : [ { "id" : 37141, "points" : [ { "x" : 730, "y" : 613 } ] }, { "id" : 37136, "points" : [ { "x" : 816, "y" : 354 } ] }, { "id" : 37134, "points" : [ { "x" : 840, "y" : 305 } ] }, { "id" : 37137, "points" : [ { "x" : 771, "y" : 429 } ] }, { "id" : 37138, "points" : [ { "x" : 793, "y" : 390 } ] } ], "outputs" : [ { "id" : 37142 } ], "catalysts" : [ { "id" : 37141, "points" : [ { "x" : 754, "y" : 613 } ] } ] }, { "id" : 37157, "reactomeId" : 10640118, "displayName" : "CST complex formation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 249, "y" : 73 }, "minX" : 196, "maxX" : 292, "minY" : 67, "maxY" : 79, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 196, "y" : 68 }, "to" : { "x" : 249, "y" : 73 } }, { "from" : { "x" : 249, "y" : 73 }, "to" : { "x" : 292, "y" : 70 } } ], "endShape" : { "a" : { "x" : 285, "y" : 74 }, "b" : { "x" : 292, "y" : 70 }, "c" : { "x" : 285, "y" : 66 }, "type" : "ARROW", "centre" : { "x" : 285, "y" : 66 } }, "reactionShape" : { "c" : { "x" : 249, "y" : 73 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 249, "y" : 73 } }, "inputs" : [ { "id" : 37158, "points" : [ { "x" : 119, "y" : 76 } ] }, { "id" : 37159, "points" : [ { "x" : 160, "y" : 51 } ] }, { "id" : 37160, "points" : [ { "x" : 114, "y" : 106 } ] } ], "outputs" : [ { "id" : 37150 } ] }, { "id" : 37143, "reactomeId" : 10570081, "displayName" : "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 685, "y" : 570 }, "minX" : 679, "maxX" : 691, "minY" : 535, "maxY" : 613, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 688, "y" : 535 }, "to" : { "x" : 685, "y" : 570 } }, { "from" : { "x" : 685, "y" : 570 }, "to" : { "x" : 683, "y" : 613 } } ], "endShape" : { "a" : { "x" : 679, "y" : 606 }, "b" : { "x" : 683, "y" : 613 }, "c" : { "x" : 687, "y" : 606 }, "type" : "ARROW", "centre" : { "x" : 687, "y" : 606 } }, "reactionShape" : { "a" : { "x" : 679, "y" : 564 }, "b" : { "x" : 691, "y" : 576 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 685, "y" : 570 } }, "inputs" : [ { "id" : 37139 } ], "outputs" : [ { "id" : 37141 } ] }, { "id" : 37144, "reactomeId" : 10569499, "displayName" : "Alignment Of The RNA Template On The Telomeric Chromosome End", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 614, "y" : 284 }, "minX" : 568, "maxX" : 646, "minY" : 278, "maxY" : 290, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 568, "y" : 282 }, "to" : { "x" : 614, "y" : 284 } }, { "from" : { "x" : 614, "y" : 284 }, "to" : { "x" : 646, "y" : 285 } } ], "endShape" : { "a" : { "x" : 639, "y" : 289 }, "b" : { "x" : 646, "y" : 285 }, "c" : { "x" : 639, "y" : 281 }, "type" : "ARROW", "centre" : { "x" : 639, "y" : 281 } }, "reactionShape" : { "a" : { "x" : 608, "y" : 278 }, "b" : { "x" : 620, "y" : 290 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 614, "y" : 284 } }, "inputs" : [ { "id" : 37145 } ], "outputs" : [ { "id" : 37135 } ] }, { "id" : 37161, "reactomeId" : 10640120, "displayName" : "Formation of the CTF18 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1314, "y" : 172 }, "minX" : 1280, "maxX" : 1338, "minY" : 163, "maxY" : 178, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1280, "y" : 163 }, "to" : { "x" : 1314, "y" : 172 } }, { "from" : { "x" : 1314, "y" : 172 }, "to" : { "x" : 1338, "y" : 172 } } ], "endShape" : { "a" : { "x" : 1331, "y" : 176 }, "b" : { "x" : 1338, "y" : 172 }, "c" : { "x" : 1331, "y" : 168 }, "type" : "ARROW", "centre" : { "x" : 1331, "y" : 168 } }, "reactionShape" : { "c" : { "x" : 1314, "y" : 172 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1314, "y" : 172 } }, "inputs" : [ { "id" : 37162, "points" : [ { "x" : 1231, "y" : 165 } ] }, { "id" : 37163, "points" : [ { "x" : 1235, "y" : 139 } ] }, { "id" : 37164, "points" : [ { "x" : 1290, "y" : 128 } ] } ], "outputs" : [ { "id" : 37165 } ] }, { "id" : 37146, "reactomeId" : 10571769, "displayName" : "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 939, "y" : 200 }, "minX" : 899, "maxX" : 981, "minY" : 194, "maxY" : 221, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 899, "y" : 199 }, "to" : { "x" : 939, "y" : 200 } }, { "from" : { "x" : 939, "y" : 200 }, "to" : { "x" : 981, "y" : 221 } } ], "endShape" : { "a" : { "x" : 973, "y" : 221 }, "b" : { "x" : 981, "y" : 221 }, "c" : { "x" : 977, "y" : 214 }, "type" : "ARROW", "centre" : { "x" : 977, "y" : 214 } }, "reactionShape" : { "a" : { "x" : 933, "y" : 194 }, "b" : { "x" : 945, "y" : 206 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 939, "y" : 200 } }, "inputs" : [ { "id" : 37147, "points" : [ { "x" : 892, "y" : 225 } ] }, { "id" : 37148, "points" : [ { "x" : 848, "y" : 199 } ] } ], "outputs" : [ { "id" : 37149 } ], "catalysts" : [ { "id" : 37148, "points" : [ { "x" : 848, "y" : 171 }, { "x" : 884, "y" : 151 } ] } ], "activators" : [ { "id" : 37150, "points" : [ { "x" : 365, "y" : 52 }, { "x" : 413, "y" : 25 }, { "x" : 939, "y" : 50 } ] } ] }, { "id" : 37133, "reactomeId" : 10569493, "displayName" : "Elongation Of The Telomeric Chromosome End", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 704, "y" : 393 }, "minX" : 695, "maxX" : 710, "minY" : 350, "maxY" : 462, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 705, "y" : 350 }, "to" : { "x" : 704, "y" : 393 } }, { "from" : { "x" : 704, "y" : 393 }, "to" : { "x" : 695, "y" : 462 } } ], "endShape" : { "a" : { "x" : 692, "y" : 455 }, "b" : { "x" : 695, "y" : 462 }, "c" : { "x" : 700, "y" : 456 }, "type" : "ARROW", "centre" : { "x" : 700, "y" : 456 } }, "reactionShape" : { "a" : { "x" : 698, "y" : 387 }, "b" : { "x" : 710, "y" : 399 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 704, "y" : 393 } }, "inputs" : [ { "id" : 37134, "points" : [ { "x" : 821, "y" : 305 }, { "x" : 773, "y" : 336 } ] }, { "id" : 37135, "points" : [ { "x" : 707, "y" : 330 } ] }, { "id" : 37136, "points" : [ { "x" : 787, "y" : 340 } ] }, { "id" : 37137, "points" : [ { "x" : 746, "y" : 393 } ] }, { "id" : 37138, "points" : [ { "x" : 763, "y" : 366 } ] } ], "outputs" : [ { "id" : 37139 } ], "catalysts" : [ { "id" : 37135, "points" : [ { "x" : 685, "y" : 330 }, { "x" : 663, "y" : 360 } ] } ] }, { "id" : 37166, "reactomeId" : 10640136, "displayName" : "DKC1 binds SHQ1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 193, "y" : 727 }, "minX" : 154, "maxX" : 250, "minY" : 713, "maxY" : 735, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 154, "y" : 735 }, "to" : { "x" : 193, "y" : 727 } }, { "from" : { "x" : 193, "y" : 727 }, "to" : { "x" : 250, "y" : 713 } } ], "endShape" : { "a" : { "x" : 244, "y" : 719 }, "b" : { "x" : 250, "y" : 713 }, "c" : { "x" : 242, "y" : 711 }, "type" : "ARROW", "centre" : { "x" : 242, "y" : 711 } }, "reactionShape" : { "c" : { "x" : 193, "y" : 727 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 193, "y" : 727 } }, "inputs" : [ { "id" : 37167, "points" : [ { "x" : 91, "y" : 442 } ] }, { "id" : 37168, "points" : [ { "x" : 152, "y" : 807 } ] } ], "outputs" : [ { "id" : 37169 } ] }, { "id" : 37151, "reactomeId" : 10571775, "displayName" : "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 961, "y" : 389 }, "minX" : 937, "maxX" : 995, "minY" : 357, "maxY" : 431, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 937, "y" : 357 }, "to" : { "x" : 961, "y" : 389 } }, { "from" : { "x" : 961, "y" : 389 }, "to" : { "x" : 995, "y" : 431 } } ], "endShape" : { "a" : { "x" : 988, "y" : 428 }, "b" : { "x" : 995, "y" : 431 }, "c" : { "x" : 994, "y" : 423 }, "type" : "ARROW", "centre" : { "x" : 994, "y" : 423 } }, "reactionShape" : { "a" : { "x" : 955, "y" : 383 }, "b" : { "x" : 967, "y" : 395 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 961, "y" : 389 } }, "inputs" : [ { "id" : 37134, "points" : [ { "x" : 858, "y" : 305 } ] }, { "id" : 37136, "points" : [ { "x" : 841, "y" : 341 } ] }, { "id" : 37137, "points" : [ { "x" : 786, "y" : 403 } ] }, { "id" : 37138, "points" : [ { "x" : 815, "y" : 370 } ] }, { "id" : 37149, "points" : [ { "x" : 1005, "y" : 281 } ] } ], "outputs" : [ { "id" : 37152 } ], "catalysts" : [ { "id" : 37149, "points" : [ { "x" : 1015, "y" : 281 } ] } ] } ], "compartments" : [ { "id" : 37170, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1070, "y" : 660 }, "minX" : 0, "maxX" : 2141, "minY" : 0, "maxY" : 1320, "prop" : { "x" : 0, "y" : 0, "width" : 2141, "height" : 1320 }, "textPosition" : { "x" : 1387, "y" : 1222 }, "insets" : { "x" : 10, "y" : 10, "width" : 2121, "height" : 1300 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 37167, 37133, 37145, 37144, 37135, 37134, 37136, 37138, 37137, 37139, 37140, 37141, 37143, 37142, 37146, 37151, 37149, 37152, 37154, 37156, 37153, 37155, 37192, 37148, 37157, 37158, 37159, 37160, 37150, 37161, 37162, 37163, 37164, 37165, 37204, 37205, 37226, 37211, 37227, 37212, 37228, 37166, 37168, 37169, 37147 ] } ], "notes" : [ ], "links" : [ { "id" : 37226, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1222, "y" : 336 }, "minX" : 1216, "maxX" : 1228, "minY" : 283, "maxY" : 390, "segments" : [ { "from" : { "x" : 1218, "y" : 283 }, "to" : { "x" : 1226, "y" : 390 } } ], "reactionShape" : { "a" : { "x" : 1216, "y" : 330 }, "b" : { "x" : 1228, "y" : 342 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1222, "y" : 336 } }, "inputs" : [ { "id" : 37204 } ], "outputs" : [ { "id" : 37205 } ] }, { "id" : 37228, "renderableClass" : "Interaction", "position" : { "x" : 1665, "y" : 1032 }, "minX" : 1638, "maxX" : 1692, "minY" : 904, "maxY" : 1161, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1638, "y" : 904 }, "to" : { "x" : 1692, "y" : 1161 } } ], "endShape" : { "a" : { "x" : 1687, "y" : 1155 }, "b" : { "x" : 1692, "y" : 1161 }, "c" : { "x" : 1694, "y" : 1153 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1694, "y" : 1153 } }, "reactionShape" : { "a" : { "x" : 1659, "y" : 1026 }, "b" : { "x" : 1671, "y" : 1038 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1665, "y" : 1032 } }, "inputs" : [ { "id" : 37192 } ], "outputs" : [ { "id" : 37212 } ] } ], "shadows" : [ { "id" : 37229, "reactomeId" : 10648204, "displayName" : "Extension of Telomeres", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 766, "y" : 639 }, "minX" : 57, "maxX" : 1475, "minY" : 16, "maxY" : 1263, "prop" : { "x" : 57, "y" : 16, "width" : 1418, "height" : 1247 }, "points" : [ { "x" : 57, "y" : 16 }, { "x" : 1475, "y" : 16 }, { "x" : 1475, "y" : 1263 }, { "x" : 57, "y" : 1263 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 2141, "minY" : 0, "maxY" : 1320, "disease" : false }