{ "dbId" : 10648144, "stableId" : "R-DRE-9753281", "displayName" : "Paracetamol ADME", "nodes" : [ { "id" : 90113, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 216, "y" : 266 }, "minX" : 114, "maxX" : 239, "minY" : 185, "maxY" : 282, "prop" : { "x" : 195, "y" : 251, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 199, "y" : 256 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 233, "y" : 256 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 233, "y" : 256 } } }, "connectors" : [ { "edgeId" : 90111, "type" : "INPUT", "segments" : [ { "from" : { "x" : 196, "y" : 248 }, "to" : { "x" : 114, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 90112, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 206, "y" : 226 }, "minX" : 114, "maxX" : 227, "minY" : 185, "maxY" : 242, "prop" : { "x" : 186, "y" : 211, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 190, "y" : 216 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 221, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 221, "y" : 216 } } }, "connectors" : [ { "edgeId" : 90111, "type" : "INPUT", "segments" : [ { "from" : { "x" : 183, "y" : 217 }, "to" : { "x" : 114, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90115, "reactomeId" : 9753562, "displayName" : "APAP-GlcA, APAP-SO3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 40, "y" : 187 }, "minX" : 0, "maxX" : 115, "minY" : 167, "maxY" : 207, "prop" : { "x" : 0, "y" : 167, "width" : 81, "height" : 40 }, "textPosition" : { "x" : 1, "y" : 169 }, "connectors" : [ { "edgeId" : 90111, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 87, "y" : 186 }, "to" : { "x" : 115, "y" : 186 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 94, "y" : 182 }, "b" : { "x" : 87, "y" : 186 }, "c" : { "x" : 94, "y" : 190 }, "type" : "ARROW", "centre" : { "x" : 94, "y" : 190 } } } ] }, { "id" : 90114, "reactomeId" : 9753559, "displayName" : "APAP-GlcA, APAP-SO3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 257, "y" : 185 }, "minX" : 114, "maxX" : 297, "minY" : 167, "maxY" : 451, "prop" : { "x" : 218, "y" : 167, "width" : 79, "height" : 36 }, "textPosition" : { "x" : 218, "y" : 167 }, "connectors" : [ { "edgeId" : 90119, "type" : "INPUT", "segments" : [ { "from" : { "x" : 257, "y" : 209 }, "to" : { "x" : 257, "y" : 451 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 90111, "type" : "INPUT", "segments" : [ { "from" : { "x" : 212, "y" : 185 }, "to" : { "x" : 114, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90117, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 169, "y" : 110 }, "minX" : 115, "maxX" : 184, "minY" : 94, "maxY" : 186, "prop" : { "x" : 156, "y" : 95, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 160, "y" : 100 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 178, "y" : 100 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 178, "y" : 100 } } }, "connectors" : [ { "edgeId" : 90111, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 157, "y" : 129 }, "to" : { "x" : 115, "y" : 186 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 156, "y" : 137 }, "b" : { "x" : 157, "y" : 129 }, "c" : { "x" : 150, "y" : 132 }, "type" : "ARROW", "centre" : { "x" : 150, "y" : 132 } } } ] }, { "id" : 90116, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 187, "y" : 148 }, "minX" : 115, "maxX" : 209, "minY" : 132, "maxY" : 186, "prop" : { "x" : 167, "y" : 133, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 171, "y" : 138 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 203, "y" : 138 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 203, "y" : 138 } } }, "connectors" : [ { "edgeId" : 90111, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 164, "y" : 158 }, "to" : { "x" : 115, "y" : 186 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 160, "y" : 165 }, "b" : { "x" : 164, "y" : 158 }, "c" : { "x" : 156, "y" : 158 }, "type" : "ARROW", "centre" : { "x" : 156, "y" : 158 } } } ] }, { "id" : 90118, "reactomeId" : 10595583, "displayName" : "abcc2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 115, "y" : 253 }, "minX" : 65, "maxX" : 171, "minY" : 193, "maxY" : 272, "prop" : { "x" : 65, "y" : 235, "width" : 100, "height" : 37 }, "textPosition" : { "x" : 92, "y" : 243 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 165, "y" : 235 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 165, "y" : 235 } } }, "connectors" : [ { "edgeId" : 90111, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 115, "y" : 229 }, "to" : { "x" : 114, "y" : 201 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 114, "y" : 197 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 114, "y" : 197 } } } ] }, { "id" : 90121, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 326, "y" : 410 }, "minX" : 257, "maxX" : 349, "minY" : 394, "maxY" : 451, "prop" : { "x" : 305, "y" : 395, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 309, "y" : 400 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 343, "y" : 400 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 343, "y" : 400 } } }, "connectors" : [ { "edgeId" : 90119, "type" : "INPUT", "segments" : [ { "from" : { "x" : 302, "y" : 422 }, "to" : { "x" : 257, "y" : 451 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 90120, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 305, "y" : 377 }, "minX" : 257, "maxX" : 326, "minY" : 361, "maxY" : 451, "prop" : { "x" : 285, "y" : 362, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 289, "y" : 367 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 320, "y" : 367 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 320, "y" : 367 } } }, "connectors" : [ { "edgeId" : 90119, "type" : "INPUT", "segments" : [ { "from" : { "x" : 294, "y" : 396 }, "to" : { "x" : 257, "y" : 451 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90123, "reactomeId" : 9753562, "displayName" : "APAP-GlcA, APAP-SO3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 259, "y" : 521 }, "minX" : 219, "maxX" : 300, "minY" : 451, "maxY" : 541, "prop" : { "x" : 219, "y" : 501, "width" : 81, "height" : 40 }, "textPosition" : { "x" : 220, "y" : 503 }, "connectors" : [ { "edgeId" : 90119, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 259, "y" : 495 }, "to" : { "x" : 259, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 255, "y" : 488 }, "b" : { "x" : 259, "y" : 495 }, "c" : { "x" : 263, "y" : 488 }, "type" : "ARROW", "centre" : { "x" : 263, "y" : 488 } } } ] }, { "id" : 90122, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 202, "y" : 389 }, "minX" : 182, "maxX" : 259, "minY" : 373, "maxY" : 451, "prop" : { "x" : 182, "y" : 374, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 186, "y" : 379 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 218, "y" : 379 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 218, "y" : 379 } } }, "connectors" : [ { "edgeId" : 90119, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 216, "y" : 408 }, "to" : { "x" : 259, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 224, "y" : 410 }, "b" : { "x" : 216, "y" : 408 }, "c" : { "x" : 218, "y" : 416 }, "type" : "ARROW", "centre" : { "x" : 218, "y" : 416 } } } ] }, { "id" : 90125, "reactomeId" : 10595585, "displayName" : "abcc4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 346, "y" : 451 }, "minX" : 265, "maxX" : 400, "minY" : 434, "maxY" : 463, "prop" : { "x" : 299, "y" : 440, "width" : 95, "height" : 23 }, "textPosition" : { "x" : 323, "y" : 441 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 394, "y" : 440 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 394, "y" : 440 } } }, "connectors" : [ { "edgeId" : 90119, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 293, "y" : 450 }, "to" : { "x" : 273, "y" : 450 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 269, "y" : 450 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 269, "y" : 450 } } } ] }, { "id" : 90124, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 189, "y" : 424 }, "minX" : 176, "maxX" : 259, "minY" : 408, "maxY" : 451, "prop" : { "x" : 176, "y" : 409, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 180, "y" : 414 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 198, "y" : 414 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 198, "y" : 414 } } }, "connectors" : [ { "edgeId" : 90119, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 206, "y" : 429 }, "to" : { "x" : 259, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 214, "y" : 428 }, "b" : { "x" : 206, "y" : 429 }, "c" : { "x" : 211, "y" : 435 }, "type" : "ARROW", "centre" : { "x" : 211, "y" : 435 } } } ] }, { "id" : 90127, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 740, "y" : 218 }, "minX" : 723, "maxX" : 775, "minY" : 185, "maxY" : 234, "prop" : { "x" : 723, "y" : 203, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 726, "y" : 208 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 752, "y" : 208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 752, "y" : 208 } } }, "connectors" : [ { "edgeId" : 90126, "type" : "INPUT", "segments" : [ { "from" : { "x" : 756, "y" : 200 }, "to" : { "x" : 775, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 90129, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 749, "y" : 150 }, "minX" : 720, "maxX" : 780, "minY" : 134, "maxY" : 185, "prop" : { "x" : 720, "y" : 135, "width" : 59, "height" : 31 }, "textPosition" : { "x" : 724, "y" : 140 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 774, "y" : 140 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 774, "y" : 140 } } }, "connectors" : [ { "edgeId" : 90126, "type" : "INPUT", "segments" : [ { "from" : { "x" : 760, "y" : 169 }, "to" : { "x" : 775, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90128, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 779, "y" : 238 }, "minX" : 762, "maxX" : 797, "minY" : 185, "maxY" : 254, "prop" : { "x" : 762, "y" : 223, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 766, "y" : 228 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 791, "y" : 228 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 791, "y" : 228 } } }, "connectors" : [ { "edgeId" : 90126, "type" : "INPUT", "segments" : [ { "from" : { "x" : 777, "y" : 220 }, "to" : { "x" : 775, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 90131, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 910, "y" : 144 }, "minX" : 881, "maxX" : 940, "minY" : 128, "maxY" : 185, "prop" : { "x" : 881, "y" : 129, "width" : 58, "height" : 31 }, "textPosition" : { "x" : 884, "y" : 134 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 934, "y" : 134 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 934, "y" : 134 } } }, "connectors" : [ { "edgeId" : 90126, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 899, "y" : 163 }, "to" : { "x" : 881, "y" : 185 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 898, "y" : 171 }, "b" : { "x" : 899, "y" : 163 }, "c" : { "x" : 892, "y" : 166 }, "type" : "ARROW", "centre" : { "x" : 892, "y" : 166 } } } ] }, { "id" : 90130, "reactomeId" : 9753466, "displayName" : "NAPQI", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 972, "y" : 185 }, "minX" : 881, "maxX" : 1040, "minY" : 169, "maxY" : 201, "prop" : { "x" : 946, "y" : 170, "width" : 53, "height" : 31 }, "textPosition" : { "x" : 950, "y" : 175 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 994, "y" : 175 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 994, "y" : 175 } } }, "connectors" : [ { "edgeId" : 90135, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1002, "y" : 185 }, "to" : { "x" : 1040, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 90126, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 943, "y" : 185 }, "to" : { "x" : 881, "y" : 185 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 936, "y" : 189 }, "b" : { "x" : 943, "y" : 185 }, "c" : { "x" : 936, "y" : 181 }, "type" : "ARROW", "centre" : { "x" : 936, "y" : 181 } } } ] }, { "id" : 90133, "reactomeId" : 10565221, "displayName" : "CYP2E1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 820, "y" : 304 }, "minX" : 793, "maxX" : 853, "minY" : 193, "maxY" : 316, "prop" : { "x" : 793, "y" : 293, "width" : 54, "height" : 23 }, "textPosition" : { "x" : 796, "y" : 287 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 847, "y" : 293 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 847, "y" : 293 } } }, "connectors" : [ { "edgeId" : 90126, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 820, "y" : 290 }, "to" : { "x" : 820, "y" : 201 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 820, "y" : 197 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 820, "y" : 197 } } } ] }, { "id" : 90132, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 905, "y" : 225 }, "minX" : 881, "maxX" : 928, "minY" : 185, "maxY" : 241, "prop" : { "x" : 884, "y" : 210, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 888, "y" : 215 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 922, "y" : 215 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 922, "y" : 215 } } }, "connectors" : [ { "edgeId" : 90126, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 895, "y" : 207 }, "to" : { "x" : 881, "y" : 185 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 888, "y" : 203 }, "b" : { "x" : 895, "y" : 207 }, "c" : { "x" : 895, "y" : 199 }, "type" : "ARROW", "centre" : { "x" : 895, "y" : 199 } } } ], "trivial" : true }, { "id" : 90134, "reactomeId" : 9753674, "displayName" : "isoniazid", "schemaClass" : "ChemicalDrug", "renderableClass" : "ChemicalDrug", "position" : { "x" : 820, "y" : 106 }, "minX" : 786, "maxX" : 854, "minY" : 91, "maxY" : 176, "prop" : { "x" : 786, "y" : 91, "width" : 68, "height" : 31 }, "textPosition" : { "x" : 789, "y" : 96 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 90126, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 820, "y" : 125 }, "to" : { "x" : 820, "y" : 176 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 816, "y" : 169 }, "b" : { "x" : 820, "y" : 176 }, "c" : { "x" : 824, "y" : 169 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 824, "y" : 169 } } } ] }, { "id" : 90137, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1144, "y" : 222 }, "minX" : 1118, "maxX" : 1167, "minY" : 185, "maxY" : 238, "prop" : { "x" : 1123, "y" : 207, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1127, "y" : 212 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1161, "y" : 212 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1161, "y" : 212 } } }, "connectors" : [ { "edgeId" : 90135, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1133, "y" : 204 }, "to" : { "x" : 1118, "y" : 185 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1126, "y" : 201 }, "b" : { "x" : 1133, "y" : 204 }, "c" : { "x" : 1132, "y" : 196 }, "type" : "ARROW", "centre" : { "x" : 1132, "y" : 196 } } } ], "trivial" : true }, { "id" : 90136, "reactomeId" : 29450, "displayName" : "GSH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1020, "y" : 216 }, "minX" : 1000, "maxX" : 1042, "minY" : 185, "maxY" : 232, "prop" : { "x" : 1000, "y" : 201, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1003, "y" : 206 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1036, "y" : 206 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1036, "y" : 206 } } }, "connectors" : [ { "edgeId" : 90135, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1030, "y" : 198 }, "to" : { "x" : 1040, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90139, "reactomeId" : 10641574, "displayName" : "GSTM1,P1,T1 dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1081, "y" : 127 }, "minX" : 1035, "maxX" : 1128, "minY" : 109, "maxY" : 177, "prop" : { "x" : 1035, "y" : 109, "width" : 93, "height" : 37 }, "textPosition" : { "x" : 1035, "y" : 110 }, "connectors" : [ { "edgeId" : 90135, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1081, "y" : 152 }, "to" : { "x" : 1082, "y" : 169 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1082, "y" : 173 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1082, "y" : 173 } } } ] }, { "id" : 90138, "reactomeId" : 9753685, "displayName" : "APAP-SG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1209, "y" : 185 }, "minX" : 1118, "maxX" : 1295, "minY" : 169, "maxY" : 201, "prop" : { "x" : 1176, "y" : 170, "width" : 66, "height" : 31 }, "textPosition" : { "x" : 1178, "y" : 175 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1237, "y" : 175 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1237, "y" : 175 } } }, "connectors" : [ { "edgeId" : 90135, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1173, "y" : 185 }, "to" : { "x" : 1118, "y" : 185 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1166, "y" : 189 }, "b" : { "x" : 1173, "y" : 185 }, "c" : { "x" : 1166, "y" : 181 }, "type" : "ARROW", "centre" : { "x" : 1166, "y" : 181 } } }, { "edgeId" : 90140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1245, "y" : 184 }, "to" : { "x" : 1295, "y" : 184 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90141, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1265, "y" : 142 }, "minX" : 1244, "maxX" : 1295, "minY" : 126, "maxY" : 184, "prop" : { "x" : 1244, "y" : 127, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1248, "y" : 132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1282, "y" : 132 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1282, "y" : 132 } } }, "connectors" : [ { "edgeId" : 90140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1276, "y" : 161 }, "to" : { "x" : 1295, "y" : 184 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 90143, "reactomeId" : 29404, "displayName" : "L-Glu", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1411, "y" : 145 }, "minX" : 1385, "maxX" : 1435, "minY" : 129, "maxY" : 184, "prop" : { "x" : 1388, "y" : 130, "width" : 46, "height" : 31 }, "textPosition" : { "x" : 1392, "y" : 135 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1429, "y" : 135 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1429, "y" : 135 } } }, "connectors" : [ { "edgeId" : 90140, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1400, "y" : 164 }, "to" : { "x" : 1385, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1399, "y" : 172 }, "b" : { "x" : 1400, "y" : 164 }, "c" : { "x" : 1393, "y" : 167 }, "type" : "ARROW", "centre" : { "x" : 1393, "y" : 167 } } } ] }, { "id" : 90142, "reactomeId" : 9753680, "displayName" : "APAP-CysGly", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1493, "y" : 184 }, "minX" : 1385, "maxX" : 1575, "minY" : 168, "maxY" : 200, "prop" : { "x" : 1449, "y" : 169, "width" : 89, "height" : 31 }, "textPosition" : { "x" : 1452, "y" : 174 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1533, "y" : 174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1533, "y" : 174 } } }, "connectors" : [ { "edgeId" : 90145, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1541, "y" : 184 }, "to" : { "x" : 1575, "y" : 184 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 90140, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1446, "y" : 184 }, "to" : { "x" : 1385, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1439, "y" : 188 }, "b" : { "x" : 1446, "y" : 184 }, "c" : { "x" : 1439, "y" : 180 }, "type" : "ARROW", "centre" : { "x" : 1439, "y" : 180 } } } ] }, { "id" : 90144, "reactomeId" : 10612758, "displayName" : "GGT dimers", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1344, "y" : 11 }, "minX" : 1305, "maxX" : 1384, "minY" : 0, "maxY" : 176, "prop" : { "x" : 1305, "y" : 0, "width" : 79, "height" : 23 }, "textPosition" : { "x" : 1305, "y" : 1 }, "connectors" : [ { "edgeId" : 90140, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1344, "y" : 29 }, "to" : { "x" : 1344, "y" : 168 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1344, "y" : 172 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1344, "y" : 172 } } } ] }, { "id" : 90147, "reactomeId" : 29424, "displayName" : "Gly", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1672, "y" : 143 }, "minX" : 1649, "maxX" : 1691, "minY" : 127, "maxY" : 184, "prop" : { "x" : 1655, "y" : 128, "width" : 35, "height" : 31 }, "textPosition" : { "x" : 1659, "y" : 133 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1685, "y" : 133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1685, "y" : 133 } } }, "connectors" : [ { "edgeId" : 90145, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1663, "y" : 162 }, "to" : { "x" : 1649, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1663, "y" : 170 }, "b" : { "x" : 1663, "y" : 162 }, "c" : { "x" : 1656, "y" : 166 }, "type" : "ARROW", "centre" : { "x" : 1656, "y" : 166 } } } ] }, { "id" : 90146, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1552, "y" : 143 }, "minX" : 1531, "maxX" : 1575, "minY" : 127, "maxY" : 184, "prop" : { "x" : 1531, "y" : 128, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1535, "y" : 133 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1569, "y" : 133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1569, "y" : 133 } } }, "connectors" : [ { "edgeId" : 90145, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1560, "y" : 162 }, "to" : { "x" : 1575, "y" : 184 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 90149, "reactomeId" : 10594272, "displayName" : "CNDP2:2Mn2+ dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1608, "y" : 88 }, "minX" : 1559, "maxX" : 1664, "minY" : 64, "maxY" : 176, "prop" : { "x" : 1559, "y" : 70, "width" : 99, "height" : 37 }, "textPosition" : { "x" : 1558, "y" : 72 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1658, "y" : 70 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1658, "y" : 70 } } }, "connectors" : [ { "edgeId" : 90145, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1608, "y" : 110 }, "to" : { "x" : 1608, "y" : 168 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1608, "y" : 172 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1608, "y" : 172 } } } ] }, { "id" : 90148, "reactomeId" : 9753653, "displayName" : "APAP-Cys", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1738, "y" : 184 }, "minX" : 1649, "maxX" : 1804, "minY" : 168, "maxY" : 200, "prop" : { "x" : 1703, "y" : 169, "width" : 71, "height" : 31 }, "textPosition" : { "x" : 1706, "y" : 174 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1769, "y" : 174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1769, "y" : 174 } } }, "connectors" : [ { "edgeId" : 90145, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1700, "y" : 184 }, "to" : { "x" : 1649, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1693, "y" : 188 }, "b" : { "x" : 1700, "y" : 184 }, "c" : { "x" : 1693, "y" : 180 }, "type" : "ARROW", "centre" : { "x" : 1693, "y" : 180 } } }, { "edgeId" : 90150, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1777, "y" : 184 }, "to" : { "x" : 1804, "y" : 184 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90151, "reactomeId" : 76183, "displayName" : "Ac-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1781, "y" : 145 }, "minX" : 1752, "maxX" : 1811, "minY" : 129, "maxY" : 184, "prop" : { "x" : 1752, "y" : 130, "width" : 58, "height" : 31 }, "textPosition" : { "x" : 1755, "y" : 135 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1805, "y" : 135 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1805, "y" : 135 } } }, "connectors" : [ { "edgeId" : 90150, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1790, "y" : 164 }, "to" : { "x" : 1804, "y" : 184 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90153, "reactomeId" : 76194, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1906, "y" : 133 }, "minX" : 1874, "maxX" : 1937, "minY" : 117, "maxY" : 184, "prop" : { "x" : 1877, "y" : 118, "width" : 59, "height" : 31 }, "textPosition" : { "x" : 1880, "y" : 123 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1931, "y" : 123 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1931, "y" : 123 } } }, "connectors" : [ { "edgeId" : 90150, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1896, "y" : 152 }, "to" : { "x" : 1874, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1895, "y" : 160 }, "b" : { "x" : 1896, "y" : 152 }, "c" : { "x" : 1889, "y" : 155 }, "type" : "ARROW", "centre" : { "x" : 1889, "y" : 155 } } } ] }, { "id" : 90152, "reactomeId" : 9753642, "displayName" : "APAP-Mer", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1908, "y" : 227 }, "minX" : 1872, "maxX" : 1946, "minY" : 184, "maxY" : 243, "prop" : { "x" : 1872, "y" : 212, "width" : 73, "height" : 31 }, "textPosition" : { "x" : 1875, "y" : 217 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1940, "y" : 217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1940, "y" : 217 } } }, "connectors" : [ { "edgeId" : 90150, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1895, "y" : 209 }, "to" : { "x" : 1874, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1887, "y" : 206 }, "b" : { "x" : 1895, "y" : 209 }, "c" : { "x" : 1894, "y" : 201 }, "type" : "ARROW", "centre" : { "x" : 1894, "y" : 201 } } } ] }, { "id" : 90154, "reactomeId" : 10641592, "displayName" : "NAT1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1841, "y" : 82 }, "minX" : 1814, "maxX" : 1868, "minY" : 71, "maxY" : 176, "prop" : { "x" : 1814, "y" : 71, "width" : 54, "height" : 23 }, "textPosition" : { "x" : 1815, "y" : 72 }, "connectors" : [ { "edgeId" : 90150, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1840, "y" : 100 }, "to" : { "x" : 1840, "y" : 168 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1840, "y" : 172 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1840, "y" : 172 } } } ] }, { "id" : 90157, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1841, "y" : 394 }, "minX" : 1784, "maxX" : 1864, "minY" : 377, "maxY" : 410, "prop" : { "x" : 1820, "y" : 379, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1824, "y" : 384 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1858, "y" : 384 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1858, "y" : 384 } } }, "connectors" : [ { "edgeId" : 90155, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1817, "y" : 387 }, "to" : { "x" : 1784, "y" : 377 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 90156, "reactomeId" : 9753629, "displayName" : "APAP-Cys,APAP-Mer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1786, "y" : 301 }, "minX" : 1725, "maxX" : 1848, "minY" : 290, "maxY" : 377, "prop" : { "x" : 1725, "y" : 290, "width" : 123, "height" : 23 }, "textPosition" : { "x" : 1734, "y" : 284 }, "connectors" : [ { "edgeId" : 90155, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1785, "y" : 319 }, "to" : { "x" : 1784, "y" : 377 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90159, "reactomeId" : 9753624, "displayName" : "APAP-Cys,APAP-Mer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1784, "y" : 519 }, "minX" : 1723, "maxX" : 1846, "minY" : 449, "maxY" : 531, "prop" : { "x" : 1723, "y" : 508, "width" : 123, "height" : 23 }, "textPosition" : { "x" : 1732, "y" : 502 }, "connectors" : [ { "edgeId" : 90155, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1784, "y" : 502 }, "to" : { "x" : 1784, "y" : 449 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1780, "y" : 495 }, "b" : { "x" : 1784, "y" : 502 }, "c" : { "x" : 1788, "y" : 495 }, "type" : "ARROW", "centre" : { "x" : 1788, "y" : 495 } } } ] }, { "id" : 90158, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1835, "y" : 351 }, "minX" : 1784, "maxX" : 1856, "minY" : 335, "maxY" : 377, "prop" : { "x" : 1815, "y" : 336, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1819, "y" : 341 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1850, "y" : 341 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1850, "y" : 341 } } }, "connectors" : [ { "edgeId" : 90155, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1812, "y" : 361 }, "to" : { "x" : 1784, "y" : 377 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90161, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1733, "y" : 391 }, "minX" : 1720, "maxX" : 1784, "minY" : 375, "maxY" : 449, "prop" : { "x" : 1720, "y" : 376, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 1724, "y" : 381 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1742, "y" : 381 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1742, "y" : 381 } } }, "connectors" : [ { "edgeId" : 90155, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1750, "y" : 406 }, "to" : { "x" : 1784, "y" : 449 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1757, "y" : 409 }, "b" : { "x" : 1750, "y" : 406 }, "c" : { "x" : 1751, "y" : 414 }, "type" : "ARROW", "centre" : { "x" : 1751, "y" : 414 } } } ] }, { "id" : 90160, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1688, "y" : 391 }, "minX" : 1668, "maxX" : 1784, "minY" : 375, "maxY" : 449, "prop" : { "x" : 1668, "y" : 376, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1672, "y" : 381 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1704, "y" : 381 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1704, "y" : 381 } } }, "connectors" : [ { "edgeId" : 90155, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1712, "y" : 403 }, "to" : { "x" : 1784, "y" : 449 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1720, "y" : 403 }, "b" : { "x" : 1712, "y" : 403 }, "c" : { "x" : 1716, "y" : 410 }, "type" : "ARROW", "centre" : { "x" : 1716, "y" : 410 } } } ] }, { "id" : 90162, "reactomeId" : 10641581, "displayName" : "ABCC1,4,5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1694, "y" : 450 }, "minX" : 1658, "maxX" : 1778, "minY" : 416, "maxY" : 462, "prop" : { "x" : 1658, "y" : 439, "width" : 72, "height" : 23 }, "textPosition" : { "x" : 1658, "y" : 440 }, "connectors" : [ { "edgeId" : 90155, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1736, "y" : 449 }, "to" : { "x" : 1771, "y" : 423 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1774, "y" : 420 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1774, "y" : 420 } } } ] }, { "id" : 90173, "reactomeId" : 10647826, "displayName" : "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 985, "y" : 63 }, "minX" : 878, "maxX" : 1093, "minY" : 35, "maxY" : 92, "prop" : { "x" : 878, "y" : 35, "width" : 215, "height" : 57 }, "textPosition" : { "x" : 888, "y" : 42 }, "connectors" : [ ] }, { "id" : 90174, "reactomeId" : 9677362, "displayName" : "APAP", "schemaClass" : "ChemicalDrug", "renderableClass" : "ChemicalDrug", "position" : { "x" : 684, "y" : 63 }, "minX" : 661, "maxX" : 708, "minY" : 48, "maxY" : 79, "prop" : { "x" : 661, "y" : 48, "width" : 47, "height" : 31 }, "textPosition" : { "x" : 664, "y" : 53 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ ] }, { "id" : 90101, "reactomeId" : 158601, "displayName" : "UDP-GlcA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 685, "y" : 258 }, "minX" : 648, "maxX" : 722, "minY" : 220, "maxY" : 274, "prop" : { "x" : 650, "y" : 243, "width" : 71, "height" : 31 }, "textPosition" : { "x" : 653, "y" : 248 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 716, "y" : 248 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 716, "y" : 248 } } }, "connectors" : [ { "edgeId" : 90100, "type" : "INPUT", "segments" : [ { "from" : { "x" : 669, "y" : 240 }, "to" : { "x" : 648, "y" : 220 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90103, "reactomeId" : 158604, "displayName" : "APAP-GlcA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 438, "y" : 220 }, "minX" : 400, "maxX" : 542, "minY" : 204, "maxY" : 236, "prop" : { "x" : 400, "y" : 205, "width" : 77, "height" : 31 }, "textPosition" : { "x" : 403, "y" : 210 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 472, "y" : 210 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 472, "y" : 210 } } }, "connectors" : [ { "edgeId" : 90100, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 480, "y" : 220 }, "to" : { "x" : 542, "y" : 220 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 487, "y" : 216 }, "b" : { "x" : 480, "y" : 220 }, "c" : { "x" : 487, "y" : 224 }, "type" : "ARROW", "centre" : { "x" : 487, "y" : 224 } } } ] }, { "id" : 90102, "reactomeId" : 9677362, "displayName" : "APAP", "schemaClass" : "ChemicalDrug", "renderableClass" : "ChemicalDrug", "position" : { "x" : 683, "y" : 186 }, "minX" : 617, "maxX" : 775, "minY" : 141, "maxY" : 220, "prop" : { "x" : 660, "y" : 171, "width" : 47, "height" : 31 }, "textPosition" : { "x" : 663, "y" : 176 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 90100, "type" : "INPUT", "segments" : [ { "from" : { "x" : 667, "y" : 205 }, "to" : { "x" : 648, "y" : 220 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 90106, "type" : "INPUT", "segments" : [ { "from" : { "x" : 660, "y" : 168 }, "to" : { "x" : 617, "y" : 141 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 90126, "type" : "INPUT", "segments" : [ { "from" : { "x" : 710, "y" : 185 }, "to" : { "x" : 775, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90105, "reactomeId" : 10568989, "displayName" : "Homologues of UGT2B15", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 594, "y" : 307 }, "minX" : 553, "maxX" : 635, "minY" : 228, "maxY" : 326, "prop" : { "x" : 553, "y" : 289, "width" : 82, "height" : 37 }, "textPosition" : { "x" : 554, "y" : 283 }, "connectors" : [ { "edgeId" : 90100, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 594, "y" : 283 }, "to" : { "x" : 594, "y" : 236 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 594, "y" : 232 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 594, "y" : 232 } } } ] }, { "id" : 90104, "reactomeId" : 110096, "displayName" : "UDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 511, "y" : 264 }, "minX" : 491, "maxX" : 542, "minY" : 220, "maxY" : 280, "prop" : { "x" : 491, "y" : 249, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 494, "y" : 254 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 527, "y" : 254 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 527, "y" : 254 } } }, "connectors" : [ { "edgeId" : 90100, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 521, "y" : 246 }, "to" : { "x" : 542, "y" : 220 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 522, "y" : 238 }, "b" : { "x" : 521, "y" : 246 }, "c" : { "x" : 528, "y" : 243 }, "type" : "ARROW", "centre" : { "x" : 528, "y" : 243 } } } ] }, { "id" : 90107, "reactomeId" : 158471, "displayName" : "PAPS", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 636, "y" : 111 }, "minX" : 614, "maxX" : 660, "minY" : 95, "maxY" : 141, "prop" : { "x" : 614, "y" : 96, "width" : 45, "height" : 31 }, "textPosition" : { "x" : 616, "y" : 101 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 654, "y" : 101 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 654, "y" : 101 } } }, "connectors" : [ { "edgeId" : 90106, "type" : "INPUT", "segments" : [ { "from" : { "x" : 626, "y" : 130 }, "to" : { "x" : 617, "y" : 141 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 90109, "reactomeId" : 9753448, "displayName" : "APAP-SO3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 428, "y" : 142 }, "minX" : 391, "maxX" : 516, "minY" : 126, "maxY" : 158, "prop" : { "x" : 391, "y" : 127, "width" : 74, "height" : 31 }, "textPosition" : { "x" : 393, "y" : 132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 460, "y" : 132 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 460, "y" : 132 } } }, "connectors" : [ { "edgeId" : 90106, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 468, "y" : 141 }, "to" : { "x" : 516, "y" : 141 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 475, "y" : 137 }, "b" : { "x" : 468, "y" : 141 }, "c" : { "x" : 475, "y" : 145 }, "type" : "ARROW", "centre" : { "x" : 475, "y" : 145 } } } ] }, { "id" : 90108, "reactomeId" : 158466, "displayName" : "PAP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 472, "y" : 169 }, "minX" : 453, "maxX" : 516, "minY" : 141, "maxY" : 185, "prop" : { "x" : 453, "y" : 154, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 456, "y" : 159 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 487, "y" : 159 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 487, "y" : 159 } } }, "connectors" : [ { "edgeId" : 90106, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 495, "y" : 156 }, "to" : { "x" : 516, "y" : 141 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 498, "y" : 149 }, "b" : { "x" : 495, "y" : 156 }, "c" : { "x" : 503, "y" : 155 }, "type" : "ARROW", "centre" : { "x" : 503, "y" : 155 } } } ] }, { "id" : 90110, "reactomeId" : 10641566, "displayName" : "SULT dimers (APAP)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 563, "y" : 70 }, "minX" : 502, "maxX" : 625, "minY" : 59, "maxY" : 133, "prop" : { "x" : 502, "y" : 59, "width" : 123, "height" : 23 }, "textPosition" : { "x" : 519, "y" : 53 }, "connectors" : [ { "edgeId" : 90106, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 563, "y" : 88 }, "to" : { "x" : 563, "y" : 125 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 563, "y" : 129 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 563, "y" : 129 } } } ] } ], "edges" : [ { "id" : 90145, "reactomeId" : 10641588, "displayName" : "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1608, "y" : 184 }, "minX" : 1575, "maxX" : 1649, "minY" : 178, "maxY" : 190, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1575, "y" : 184 }, "to" : { "x" : 1608, "y" : 184 } }, { "from" : { "x" : 1608, "y" : 184 }, "to" : { "x" : 1649, "y" : 184 } } ], "reactionShape" : { "a" : { "x" : 1602, "y" : 178 }, "b" : { "x" : 1614, "y" : 190 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1608, "y" : 184 } }, "inputs" : [ { "id" : 90142, "points" : [ { "x" : 1541, "y" : 184 } ] }, { "id" : 90146, "points" : [ { "x" : 1560, "y" : 162 } ] } ], "outputs" : [ { "id" : 90147, "points" : [ { "x" : 1663, "y" : 162 } ] }, { "id" : 90148, "points" : [ { "x" : 1700, "y" : 184 } ] } ], "catalysts" : [ { "id" : 90149, "points" : [ { "x" : 1608, "y" : 110 } ] } ] }, { "id" : 90100, "reactomeId" : 10568992, "displayName" : "UGTs glucuronate APAP to APAP-GlcA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 594, "y" : 220 }, "minX" : 542, "maxX" : 648, "minY" : 214, "maxY" : 226, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 648, "y" : 220 }, "to" : { "x" : 594, "y" : 220 } }, { "from" : { "x" : 594, "y" : 220 }, "to" : { "x" : 542, "y" : 220 } } ], "reactionShape" : { "a" : { "x" : 588, "y" : 214 }, "b" : { "x" : 600, "y" : 226 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 594, "y" : 220 } }, "inputs" : [ { "id" : 90101, "points" : [ { "x" : 669, "y" : 240 } ] }, { "id" : 90102, "points" : [ { "x" : 667, "y" : 205 } ] } ], "outputs" : [ { "id" : 90103, "points" : [ { "x" : 480, "y" : 220 } ] }, { "id" : 90104, "points" : [ { "x" : 521, "y" : 246 } ] } ], "catalysts" : [ { "id" : 90105, "points" : [ { "x" : 594, "y" : 283 } ] } ] }, { "id" : 90119, "reactomeId" : 10641579, "displayName" : "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 257, "y" : 450 }, "minX" : 251, "maxX" : 263, "minY" : 444, "maxY" : 456, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 257, "y" : 451 }, "to" : { "x" : 257, "y" : 450 } }, { "from" : { "x" : 257, "y" : 450 }, "to" : { "x" : 259, "y" : 451 } } ], "reactionShape" : { "a" : { "x" : 251, "y" : 444 }, "b" : { "x" : 263, "y" : 456 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 257, "y" : 450 } }, "inputs" : [ { "id" : 90120, "points" : [ { "x" : 294, "y" : 396 } ] }, { "id" : 90121, "points" : [ { "x" : 302, "y" : 422 } ] }, { "id" : 90114, "points" : [ { "x" : 257, "y" : 209 } ] } ], "outputs" : [ { "id" : 90122, "points" : [ { "x" : 216, "y" : 408 } ] }, { "id" : 90123, "points" : [ { "x" : 259, "y" : 495 } ] }, { "id" : 90124, "points" : [ { "x" : 206, "y" : 429 } ] } ], "catalysts" : [ { "id" : 90125, "points" : [ { "x" : 293, "y" : 450 } ] } ] }, { "id" : 90135, "reactomeId" : 10641577, "displayName" : "GSTs transfer GSH to NAPQI to form APAP-SG", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1082, "y" : 185 }, "minX" : 1040, "maxX" : 1118, "minY" : 179, "maxY" : 191, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1040, "y" : 185 }, "to" : { "x" : 1082, "y" : 185 } }, { "from" : { "x" : 1082, "y" : 185 }, "to" : { "x" : 1118, "y" : 185 } } ], "reactionShape" : { "a" : { "x" : 1076, "y" : 179 }, "b" : { "x" : 1088, "y" : 191 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1082, "y" : 185 } }, "inputs" : [ { "id" : 90136, "points" : [ { "x" : 1030, "y" : 198 } ] }, { "id" : 90130, "points" : [ { "x" : 1002, "y" : 185 } ] } ], "outputs" : [ { "id" : 90137, "points" : [ { "x" : 1133, "y" : 204 } ] }, { "id" : 90138, "points" : [ { "x" : 1173, "y" : 185 } ] } ], "catalysts" : [ { "id" : 90139, "points" : [ { "x" : 1081, "y" : 152 } ] } ] }, { "id" : 90150, "reactomeId" : 10641595, "displayName" : "NAT1,2 acetylate APAP-Cys to APAP-Mer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1840, "y" : 184 }, "minX" : 1804, "maxX" : 1874, "minY" : 178, "maxY" : 190, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1804, "y" : 184 }, "to" : { "x" : 1840, "y" : 184 } }, { "from" : { "x" : 1840, "y" : 184 }, "to" : { "x" : 1874, "y" : 184 } } ], "reactionShape" : { "a" : { "x" : 1834, "y" : 178 }, "b" : { "x" : 1846, "y" : 190 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1840, "y" : 184 } }, "inputs" : [ { "id" : 90148, "points" : [ { "x" : 1777, "y" : 184 } ] }, { "id" : 90151, "points" : [ { "x" : 1790, "y" : 164 } ] } ], "outputs" : [ { "id" : 90152, "points" : [ { "x" : 1895, "y" : 209 } ] }, { "id" : 90153, "points" : [ { "x" : 1896, "y" : 152 } ] } ], "catalysts" : [ { "id" : 90154, "points" : [ { "x" : 1840, "y" : 100 } ] } ] }, { "id" : 90155, "reactomeId" : 10641584, "displayName" : "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1784, "y" : 413 }, "minX" : 1778, "maxX" : 1790, "minY" : 377, "maxY" : 455, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1784, "y" : 377 }, "to" : { "x" : 1784, "y" : 413 } }, { "from" : { "x" : 1784, "y" : 413 }, "to" : { "x" : 1784, "y" : 449 } } ], "reactionShape" : { "a" : { "x" : 1778, "y" : 407 }, "b" : { "x" : 1790, "y" : 419 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1784, "y" : 413 } }, "inputs" : [ { "id" : 90156, "points" : [ { "x" : 1785, "y" : 319 } ] }, { "id" : 90157, "points" : [ { "x" : 1817, "y" : 387 } ] }, { "id" : 90158, "points" : [ { "x" : 1812, "y" : 361 } ] } ], "outputs" : [ { "id" : 90159, "points" : [ { "x" : 1784, "y" : 502 } ] }, { "id" : 90160, "points" : [ { "x" : 1712, "y" : 403 } ] }, { "id" : 90161, "points" : [ { "x" : 1750, "y" : 406 } ] } ], "catalysts" : [ { "id" : 90162, "points" : [ { "x" : 1736, "y" : 449 } ] } ] }, { "id" : 90106, "reactomeId" : 10641569, "displayName" : "SULT dimers sulfate APAP to APAP-SO3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 563, "y" : 141 }, "minX" : 516, "maxX" : 617, "minY" : 135, "maxY" : 147, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 617, "y" : 141 }, "to" : { "x" : 563, "y" : 141 } }, { "from" : { "x" : 563, "y" : 141 }, "to" : { "x" : 516, "y" : 141 } } ], "reactionShape" : { "a" : { "x" : 557, "y" : 135 }, "b" : { "x" : 569, "y" : 147 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 563, "y" : 141 } }, "inputs" : [ { "id" : 90102, "points" : [ { "x" : 660, "y" : 168 } ] }, { "id" : 90107, "points" : [ { "x" : 626, "y" : 130 } ] } ], "outputs" : [ { "id" : 90108, "points" : [ { "x" : 495, "y" : 156 } ] }, { "id" : 90109, "points" : [ { "x" : 468, "y" : 141 } ] } ], "catalysts" : [ { "id" : 90110, "points" : [ { "x" : 563, "y" : 88 } ] } ] }, { "id" : 90140, "reactomeId" : 10641590, "displayName" : "GGT dimers hydrolyse APAP-SG", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1344, "y" : 184 }, "minX" : 1295, "maxX" : 1385, "minY" : 178, "maxY" : 190, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1295, "y" : 184 }, "to" : { "x" : 1344, "y" : 184 } }, { "from" : { "x" : 1344, "y" : 184 }, "to" : { "x" : 1385, "y" : 184 } } ], "reactionShape" : { "a" : { "x" : 1338, "y" : 178 }, "b" : { "x" : 1350, "y" : 190 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1344, "y" : 184 } }, "inputs" : [ { "id" : 90141, "points" : [ { "x" : 1276, "y" : 161 } ] }, { "id" : 90138, "points" : [ { "x" : 1245, "y" : 184 } ] } ], "outputs" : [ { "id" : 90142, "points" : [ { "x" : 1446, "y" : 184 } ] }, { "id" : 90143, "points" : [ { "x" : 1400, "y" : 164 } ] } ], "catalysts" : [ { "id" : 90144, "points" : [ { "x" : 1344, "y" : 29 } ] } ] }, { "id" : 90111, "reactomeId" : 10641572, "displayName" : "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 114, "y" : 185 }, "minX" : 109, "maxX" : 121, "minY" : 180, "maxY" : 192, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 114, "y" : 185 }, "to" : { "x" : 115, "y" : 186 } } ], "reactionShape" : { "a" : { "x" : 108, "y" : 179 }, "b" : { "x" : 120, "y" : 191 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 114, "y" : 185 } }, "inputs" : [ { "id" : 90112, "points" : [ { "x" : 183, "y" : 217 } ] }, { "id" : 90113, "points" : [ { "x" : 196, "y" : 248 } ] }, { "id" : 90114, "points" : [ { "x" : 212, "y" : 185 } ] } ], "outputs" : [ { "id" : 90115, "points" : [ { "x" : 87, "y" : 186 } ] }, { "id" : 90116, "points" : [ { "x" : 164, "y" : 158 } ] }, { "id" : 90117, "points" : [ { "x" : 157, "y" : 129 } ] } ], "catalysts" : [ { "id" : 90118, "points" : [ { "x" : 115, "y" : 229 } ] } ] }, { "id" : 90126, "reactomeId" : 10641586, "displayName" : "CYP2E1 monooxygenates APAP to NAPQI", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 820, "y" : 185 }, "minX" : 775, "maxX" : 881, "minY" : 179, "maxY" : 191, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 775, "y" : 185 }, "to" : { "x" : 820, "y" : 185 } }, { "from" : { "x" : 820, "y" : 185 }, "to" : { "x" : 881, "y" : 185 } } ], "reactionShape" : { "a" : { "x" : 814, "y" : 179 }, "b" : { "x" : 826, "y" : 191 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 820, "y" : 185 } }, "inputs" : [ { "id" : 90127, "points" : [ { "x" : 756, "y" : 200 } ] }, { "id" : 90128, "points" : [ { "x" : 777, "y" : 220 } ] }, { "id" : 90129, "points" : [ { "x" : 760, "y" : 169 } ] }, { "id" : 90102, "points" : [ { "x" : 710, "y" : 185 } ] } ], "outputs" : [ { "id" : 90130, "points" : [ { "x" : 943, "y" : 185 } ] }, { "id" : 90131, "points" : [ { "x" : 899, "y" : 163 } ] }, { "id" : 90132, "points" : [ { "x" : 895, "y" : 207 } ] } ], "catalysts" : [ { "id" : 90133, "points" : [ { "x" : 820, "y" : 290 } ] } ], "activators" : [ { "id" : 90134, "points" : [ { "x" : 820, "y" : 125 } ] } ] } ], "compartments" : [ { "id" : 90163, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1044, "y" : 231 }, "minX" : 107, "maxX" : 1982, "minY" : 8, "maxY" : 454, "prop" : { "x" : 107, "y" : 8, "width" : 1875, "height" : 446 }, "textPosition" : { "x" : 164, "y" : 51 }, "insets" : { "x" : 117, "y" : 18, "width" : 1855, "height" : 426 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 90164, 90101, 90102, 90103, 90104, 90100, 90109, 90110, 90107, 90106, 90108, 90111, 90175, 90176, 90117, 90118, 90114, 90116, 90113, 90112, 90126, 90127, 90129, 90130, 90131, 90132, 90119, 90125, 90121, 90120, 90122, 90124, 90167, 90165, 90128, 90135, 90136, 90137, 90138, 90139, 90144, 90140, 90142, 90143, 90141, 90145, 90146, 90147, 90148, 90149, 90134, 90150, 90151, 90152, 90153, 90155, 90156, 90177, 90178, 90157, 90158, 90160, 90162, 90161, 90154, 90173, 90174, 90179 ] }, { "id" : 90164, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 693, "y" : 356 }, "minX" : 504, "maxX" : 882, "minY" : 307, "maxY" : 405, "prop" : { "x" : 504, "y" : 307, "width" : 378, "height" : 98 }, "textPosition" : { "x" : 550, "y" : 340 }, "insets" : { "x" : 514, "y" : 317, "width" : 358, "height" : 78 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 90105, 90133 ] } ], "notes" : [ { "id" : 90165, "displayName" : "canalicular membrane", "renderableClass" : "Note", "position" : { "x" : 78, "y" : 311 }, "minX" : 39, "maxX" : 117, "minY" : 295, "maxY" : 328, "prop" : { "x" : 39, "y" : 295, "width" : 78, "height" : 33 }, "textPosition" : { "x" : 38, "y" : 294 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 255 } }, { "id" : 90167, "displayName" : "hepatocyte", "renderableClass" : "Note", "position" : { "x" : 193, "y" : 51 }, "minX" : 155, "maxX" : 231, "minY" : 41, "maxY" : 62, "prop" : { "x" : 155, "y" : 41, "width" : 76, "height" : 21 }, "textPosition" : { "x" : 157, "y" : 34 } }, { "id" : 90166, "displayName" : "basolateral membrane", "renderableClass" : "Note", "position" : { "x" : 178, "y" : 477 }, "minX" : 139, "maxX" : 218, "minY" : 461, "maxY" : 493, "prop" : { "x" : 139, "y" : 461, "width" : 79, "height" : 32 }, "textPosition" : { "x" : 137, "y" : 460 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 255 } } ], "links" : [ { "id" : 90177, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1762, "y" : 243 }, "minX" : 1744, "maxX" : 1781, "minY" : 203, "maxY" : 284, "segments" : [ { "from" : { "x" : 1744, "y" : 203 }, "to" : { "x" : 1781, "y" : 284 } } ], "reactionShape" : { "a" : { "x" : 1756, "y" : 237 }, "b" : { "x" : 1768, "y" : 249 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1762, "y" : 243 } }, "inputs" : [ { "id" : 90148 } ], "outputs" : [ { "id" : 90156 } ] }, { "id" : 90176, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 345, "y" : 162 }, "minX" : 303, "maxX" : 388, "minY" : 151, "maxY" : 174, "segments" : [ { "from" : { "x" : 388, "y" : 151 }, "to" : { "x" : 303, "y" : 174 } } ], "reactionShape" : { "a" : { "x" : 339, "y" : 156 }, "b" : { "x" : 351, "y" : 168 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 345, "y" : 162 } }, "inputs" : [ { "id" : 90109 } ], "outputs" : [ { "id" : 90114 } ] }, { "id" : 90179, "renderableClass" : "Interaction", "position" : { "x" : 793, "y" : 62 }, "minX" : 711, "maxX" : 875, "minY" : 56, "maxY" : 68, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 711, "y" : 62 }, "to" : { "x" : 875, "y" : 62 } } ], "endShape" : { "a" : { "x" : 868, "y" : 66 }, "b" : { "x" : 875, "y" : 62 }, "c" : { "x" : 868, "y" : 58 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 868, "y" : 58 } }, "reactionShape" : { "a" : { "x" : 787, "y" : 56 }, "b" : { "x" : 799, "y" : 68 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 793, "y" : 62 } }, "inputs" : [ { "id" : 90174 } ], "outputs" : [ { "id" : 90173 } ] }, { "id" : 90178, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1842, "y" : 265 }, "minX" : 1805, "maxX" : 1879, "minY" : 246, "maxY" : 284, "segments" : [ { "from" : { "x" : 1879, "y" : 246 }, "to" : { "x" : 1805, "y" : 284 } } ], "reactionShape" : { "a" : { "x" : 1836, "y" : 259 }, "b" : { "x" : 1848, "y" : 271 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1842, "y" : 265 } }, "inputs" : [ { "id" : 90152 } ], "outputs" : [ { "id" : 90156 } ] }, { "id" : 90175, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 350, "y" : 202 }, "minX" : 303, "maxX" : 397, "minY" : 192, "maxY" : 212, "segments" : [ { "from" : { "x" : 397, "y" : 212 }, "to" : { "x" : 303, "y" : 192 } } ], "reactionShape" : { "a" : { "x" : 344, "y" : 196 }, "b" : { "x" : 356, "y" : 208 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 350, "y" : 202 } }, "inputs" : [ { "id" : 90103 } ], "outputs" : [ { "id" : 90114 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1982, "minY" : 0, "maxY" : 541, "disease" : false }