{
  "dbId" : 10558669,
  "stableId" : "R-SSC-8949664",
  "displayName" : "Processing of SMDT1",
  "nodes" : [ {
    "id" : 125425,
    "reactomeId" : 10539969,
    "displayName" : "proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 241,
      "y" : 159
    },
    "minX" : 181,
    "maxX" : 308,
    "minY" : 128,
    "maxY" : 185,
    "prop" : {
      "x" : 181,
      "y" : 134,
      "width" : 121,
      "height" : 51
    },
    "textPosition" : {
      "x" : 186,
      "y" : 136
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 302,
          "y" : 134
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 302,
          "y" : 134
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125426,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 125422,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 125424,
    "reactomeId" : 10539967,
    "displayName" : "SMDT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 68,
      "y" : 47
    },
    "minX" : 29,
    "maxX" : 237,
    "minY" : 28,
    "maxY" : 74,
    "prop" : {
      "x" : 29,
      "y" : 34,
      "width" : 78,
      "height" : 27
    },
    "textPosition" : {
      "x" : 43,
      "y" : 37
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 107,
          "y" : 34
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 107,
          "y" : 34
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125422,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 110,
          "y" : 53
        },
        "to" : {
          "x" : 237,
          "y" : 74
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 125427,
    "reactomeId" : 10539971,
    "displayName" : "SMDT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 485,
      "y" : 235
    },
    "minX" : 454,
    "maxX" : 522,
    "minY" : 157,
    "maxY" : 261,
    "prop" : {
      "x" : 454,
      "y" : 209,
      "width" : 62,
      "height" : 52
    },
    "textPosition" : {
      "x" : 460,
      "y" : 224
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 516,
          "y" : 209
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 516,
          "y" : 209
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125426,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 482,
          "y" : 206
        },
        "to" : {
          "x" : 478,
          "y" : 157
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 477,
          "y" : 199
        },
        "b" : {
          "x" : 482,
          "y" : 206
        },
        "c" : {
          "x" : 485,
          "y" : 199
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 485,
          "y" : 199
        }
      }
    } ]
  }, {
    "id" : 125429,
    "reactomeId" : 10539983,
    "displayName" : "Mitochondrial processing peptidase",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 343,
      "y" : 230
    },
    "minX" : 295,
    "maxX" : 398,
    "minY" : 168,
    "maxY" : 255,
    "prop" : {
      "x" : 295,
      "y" : 205,
      "width" : 97,
      "height" : 50
    },
    "textPosition" : {
      "x" : 295,
      "y" : 206
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 392,
          "y" : 205
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 392,
          "y" : 205
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125426,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 339,
          "y" : 202
        },
        "to" : {
          "x" : 336,
          "y" : 176
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 335,
          "y" : 172
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 335,
          "y" : 172
        }
      }
    } ]
  }, {
    "id" : 125428,
    "reactomeId" : 10539920,
    "displayName" : "SMDT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 537,
      "y" : 138
    },
    "minX" : 478,
    "maxX" : 634,
    "minY" : 121,
    "maxY" : 163,
    "prop" : {
      "x" : 512,
      "y" : 127,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 512,
      "y" : 127
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 563,
          "y" : 127
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 563,
          "y" : 127
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125426,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 509,
          "y" : 146
        },
        "to" : {
          "x" : 478,
          "y" : 157
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 504,
          "y" : 152
        },
        "b" : {
          "x" : 509,
          "y" : 146
        },
        "c" : {
          "x" : 501,
          "y" : 145
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 501,
          "y" : 145
        }
      }
    }, {
      "edgeId" : 125430,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 566,
          "y" : 144
        },
        "to" : {
          "x" : 634,
          "y" : 163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 125436,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 125431,
    "reactomeId" : 10539916,
    "displayName" : "MICU1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 576,
      "y" : 97
    },
    "minX" : 553,
    "maxX" : 634,
    "minY" : 80,
    "maxY" : 163,
    "prop" : {
      "x" : 553,
      "y" : 86,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 553,
      "y" : 86
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 599,
          "y" : 86
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 599,
          "y" : 86
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125430,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 585,
          "y" : 111
        },
        "to" : {
          "x" : 634,
          "y" : 163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 125433,
    "reactomeId" : 10539930,
    "displayName" : "MICU2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 634,
      "y" : 60
    },
    "minX" : 605,
    "maxX" : 664,
    "minY" : 49,
    "maxY" : 163,
    "prop" : {
      "x" : 605,
      "y" : 49,
      "width" : 59,
      "height" : 22
    },
    "textPosition" : {
      "x" : 605,
      "y" : 49
    },
    "connectors" : [ {
      "edgeId" : 125430,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 634,
          "y" : 77
        },
        "to" : {
          "x" : 634,
          "y" : 163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 125432,
    "reactomeId" : 10539908,
    "displayName" : "MCU",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 692,
      "y" : 98
    },
    "minX" : 634,
    "maxX" : 716,
    "minY" : 81,
    "maxY" : 163,
    "prop" : {
      "x" : 674,
      "y" : 87,
      "width" : 36,
      "height" : 22
    },
    "textPosition" : {
      "x" : 674,
      "y" : 87
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 710,
          "y" : 87
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 710,
          "y" : 87
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125430,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 682,
          "y" : 112
        },
        "to" : {
          "x" : 634,
          "y" : 163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 125435,
    "reactomeId" : 10539932,
    "displayName" : "MCU complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 645,
      "y" : 262
    },
    "minX" : 569,
    "maxX" : 728,
    "minY" : 243,
    "maxY" : 276,
    "prop" : {
      "x" : 569,
      "y" : 249,
      "width" : 153,
      "height" : 27
    },
    "textPosition" : {
      "x" : 600,
      "y" : 255
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 722,
          "y" : 249
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 722,
          "y" : 249
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125430,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 125434,
    "reactomeId" : 10539912,
    "displayName" : "MCUB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 693,
      "y" : 143
    },
    "minX" : 634,
    "maxX" : 721,
    "minY" : 126,
    "maxY" : 163,
    "prop" : {
      "x" : 671,
      "y" : 132,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 671,
      "y" : 132
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 715,
          "y" : 132
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 715,
          "y" : 132
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125430,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 668,
          "y" : 150
        },
        "to" : {
          "x" : 634,
          "y" : 163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 125423,
    "reactomeId" : 10539965,
    "displayName" : "C2orf47:AFG3L2:SPG7:PHB:PHB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 340,
      "y" : 49
    },
    "minX" : 237,
    "maxX" : 527,
    "minY" : 27,
    "maxY" : 157,
    "prop" : {
      "x" : 282,
      "y" : 33,
      "width" : 117,
      "height" : 33
    },
    "textPosition" : {
      "x" : 285,
      "y" : 31
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 399,
          "y" : 33
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 399,
          "y" : 33
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 125426,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 361,
          "y" : 69
        },
        "to" : {
          "x" : 478,
          "y" : 157
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 369,
          "y" : 70
        },
        "b" : {
          "x" : 361,
          "y" : 69
        },
        "c" : {
          "x" : 364,
          "y" : 76
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 364,
          "y" : 76
        }
      }
    }, {
      "edgeId" : 125436,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 402,
          "y" : 56
        },
        "to" : {
          "x" : 519,
          "y" : 72
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 523,
          "y" : 72
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 523,
          "y" : 72
        }
      }
    }, {
      "edgeId" : 125422,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 279,
          "y" : 63
        },
        "to" : {
          "x" : 237,
          "y" : 74
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 125426,
    "reactomeId" : 10539986,
    "displayName" : "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 334,
      "y" : 160
    },
    "minX" : 305,
    "maxX" : 478,
    "minY" : 154,
    "maxY" : 166,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 305,
        "y" : 159
      },
      "to" : {
        "x" : 334,
        "y" : 160
      }
    }, {
      "from" : {
        "x" : 334,
        "y" : 160
      },
      "to" : {
        "x" : 478,
        "y" : 157
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 328,
        "y" : 154
      },
      "b" : {
        "x" : 340,
        "y" : 166
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 334,
        "y" : 160
      }
    },
    "inputs" : [ {
      "id" : 125425
    } ],
    "outputs" : [ {
      "id" : 125423,
      "points" : [ {
        "x" : 361,
        "y" : 69
      } ]
    }, {
      "id" : 125427,
      "points" : [ {
        "x" : 482,
        "y" : 206
      } ]
    }, {
      "id" : 125428,
      "points" : [ {
        "x" : 509,
        "y" : 146
      } ]
    } ],
    "catalysts" : [ {
      "id" : 125429,
      "points" : [ {
        "x" : 339,
        "y" : 202
      } ]
    } ]
  }, {
    "id" : 125430,
    "reactomeId" : 10541353,
    "displayName" : "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 632,
      "y" : 207
    },
    "minX" : 626,
    "maxX" : 641,
    "minY" : 163,
    "maxY" : 246,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 634,
        "y" : 163
      },
      "to" : {
        "x" : 632,
        "y" : 207
      }
    }, {
      "from" : {
        "x" : 632,
        "y" : 207
      },
      "to" : {
        "x" : 641,
        "y" : 246
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 636,
        "y" : 240
      },
      "b" : {
        "x" : 641,
        "y" : 246
      },
      "c" : {
        "x" : 643,
        "y" : 238
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 643,
        "y" : 238
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 632,
        "y" : 207
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 632,
        "y" : 207
      }
    },
    "inputs" : [ {
      "id" : 125428,
      "points" : [ {
        "x" : 566,
        "y" : 144
      } ]
    }, {
      "id" : 125431,
      "points" : [ {
        "x" : 585,
        "y" : 111
      } ]
    }, {
      "id" : 125432,
      "points" : [ {
        "x" : 682,
        "y" : 112
      } ]
    }, {
      "id" : 125433,
      "points" : [ {
        "x" : 634,
        "y" : 77
      } ]
    }, {
      "id" : 125434,
      "points" : [ {
        "x" : 668,
        "y" : 150
      } ]
    } ],
    "outputs" : [ {
      "id" : 125435
    } ]
  }, {
    "id" : 125436,
    "reactomeId" : 10539989,
    "displayName" : "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 535,
      "y" : 74
    },
    "minX" : 529,
    "maxX" : 541,
    "minY" : 33,
    "maxY" : 124,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 536,
        "y" : 124
      },
      "to" : {
        "x" : 535,
        "y" : 74
      }
    }, {
      "from" : {
        "x" : 535,
        "y" : 74
      },
      "to" : {
        "x" : 535,
        "y" : 33
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 529,
        "y" : 68
      },
      "b" : {
        "x" : 541,
        "y" : 80
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 535,
        "y" : 74
      }
    },
    "inputs" : [ {
      "id" : 125428
    } ],
    "catalysts" : [ {
      "id" : 125423,
      "points" : [ {
        "x" : 402,
        "y" : 56
      } ]
    } ]
  }, {
    "id" : 125422,
    "reactomeId" : 10539991,
    "displayName" : "C2orf47:AFG3L2 binds the transit peptide of SMDT1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 236,
      "y" : 103
    },
    "minX" : 230,
    "maxX" : 242,
    "minY" : 74,
    "maxY" : 131,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 237,
        "y" : 74
      },
      "to" : {
        "x" : 236,
        "y" : 103
      }
    }, {
      "from" : {
        "x" : 236,
        "y" : 103
      },
      "to" : {
        "x" : 238,
        "y" : 131
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 234,
        "y" : 124
      },
      "b" : {
        "x" : 238,
        "y" : 131
      },
      "c" : {
        "x" : 241,
        "y" : 124
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 241,
        "y" : 124
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 236,
        "y" : 103
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 236,
        "y" : 103
      }
    },
    "inputs" : [ {
      "id" : 125423,
      "points" : [ {
        "x" : 279,
        "y" : 63
      } ]
    }, {
      "id" : 125424,
      "points" : [ {
        "x" : 110,
        "y" : 53
      } ]
    } ],
    "outputs" : [ {
      "id" : 125425
    } ]
  } ],
  "compartments" : [ {
    "id" : 125437,
    "reactomeId" : 5460,
    "displayName" : "mitochondrial matrix",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 373,
      "y" : 164
    },
    "minX" : 24,
    "maxX" : 723,
    "minY" : 18,
    "maxY" : 311,
    "prop" : {
      "x" : 24,
      "y" : 18,
      "width" : 699,
      "height" : 293
    },
    "textPosition" : {
      "x" : 35,
      "y" : 247
    },
    "insets" : {
      "x" : 34,
      "y" : 28,
      "width" : 679,
      "height" : 273
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 125423, 125424, 125422, 125425, 125426, 125427, 125428, 125429, 125431, 125435, 125430, 125432, 125434, 125436, 125433 ]
  }, {
    "id" : 125438,
    "reactomeId" : 17927,
    "displayName" : "mitochondrial intermembrane space",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 370,
      "y" : 181
    },
    "minX" : 0,
    "maxX" : 741,
    "minY" : 0,
    "maxY" : 363,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 741,
      "height" : 363
    },
    "textPosition" : {
      "x" : 14,
      "y" : 315
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 721,
      "height" : 343
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 125437 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 741,
  "minY" : 0,
  "maxY" : 363,
  "disease" : false
}