{
  "dbId" : 10558159,
  "stableId" : "R-SSC-4755510",
  "displayName" : "SUMOylation of immune response proteins",
  "nodes" : [ {
    "id" : 147862,
    "reactomeId" : 10510763,
    "displayName" : "phospho-p-S172-IKBKE",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 107,
      "y" : 86
    },
    "minX" : 50,
    "maxX" : 178,
    "minY" : 66,
    "maxY" : 121,
    "prop" : {
      "x" : 50,
      "y" : 72,
      "width" : 114,
      "height" : 28
    },
    "textPosition" : {
      "x" : 67,
      "y" : 69
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 164,
          "y" : 72
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 164,
          "y" : 72
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147861,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 135,
          "y" : 103
        },
        "to" : {
          "x" : 178,
          "y" : 121
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 147863,
    "reactomeId" : 10505873,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 242,
      "y" : 83
    },
    "minX" : 177,
    "maxX" : 314,
    "minY" : 64,
    "maxY" : 121,
    "prop" : {
      "x" : 177,
      "y" : 70,
      "width" : 131,
      "height" : 27
    },
    "textPosition" : {
      "x" : 182,
      "y" : 76
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 308,
          "y" : 70
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 308,
          "y" : 70
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147861,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 219,
          "y" : 100
        },
        "to" : {
          "x" : 178,
          "y" : 121
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 147866,
    "reactomeId" : 10509607,
    "displayName" : "TOPORS",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 105,
      "y" : 145
    },
    "minX" : 68,
    "maxX" : 169,
    "minY" : 127,
    "maxY" : 157,
    "prop" : {
      "x" : 68,
      "y" : 133,
      "width" : 74,
      "height" : 24
    },
    "textPosition" : {
      "x" : 76,
      "y" : 134
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 142,
          "y" : 133
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 142,
          "y" : 133
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147861,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 145,
          "y" : 143
        },
        "to" : {
          "x" : 161,
          "y" : 142
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 165,
          "y" : 142
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 165,
          "y" : 142
        }
      }
    } ]
  }, {
    "id" : 147864,
    "reactomeId" : 10505865,
    "displayName" : "UBE2I",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 256,
      "y" : 202
    },
    "minX" : 178,
    "maxX" : 295,
    "minY" : 165,
    "maxY" : 216,
    "prop" : {
      "x" : 224,
      "y" : 188,
      "width" : 65,
      "height" : 28
    },
    "textPosition" : {
      "x" : 234,
      "y" : 191
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 289,
          "y" : 188
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 289,
          "y" : 188
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147861,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 226,
          "y" : 185
        },
        "to" : {
          "x" : 178,
          "y" : 165
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 218,
          "y" : 186
        },
        "b" : {
          "x" : 226,
          "y" : 185
        },
        "c" : {
          "x" : 221,
          "y" : 179
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 221,
          "y" : 179
        }
      }
    } ]
  }, {
    "id" : 147865,
    "reactomeId" : 10510766,
    "displayName" : "phospho-monoSUMO1-K231-p-S172-IKBKE",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 116,
      "y" : 215
    },
    "minX" : 53,
    "maxX" : 185,
    "minY" : 165,
    "maxY" : 237,
    "prop" : {
      "x" : 53,
      "y" : 193,
      "width" : 126,
      "height" : 44
    },
    "textPosition" : {
      "x" : 53,
      "y" : 191
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 179,
          "y" : 193
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 179,
          "y" : 193
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147861,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 143,
          "y" : 190
        },
        "to" : {
          "x" : 178,
          "y" : 165
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 146,
          "y" : 183
        },
        "b" : {
          "x" : 143,
          "y" : 190
        },
        "c" : {
          "x" : 151,
          "y" : 189
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 151,
          "y" : 189
        }
      }
    } ]
  }, {
    "id" : 147870,
    "reactomeId" : 10510749,
    "displayName" : "monoSUMO1-K277,K309-IKBKG",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 399,
      "y" : 214
    },
    "minX" : 336,
    "maxX" : 469,
    "minY" : 173,
    "maxY" : 235,
    "prop" : {
      "x" : 336,
      "y" : 194,
      "width" : 127,
      "height" : 41
    },
    "textPosition" : {
      "x" : 336,
      "y" : 197
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 463,
          "y" : 194
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 463,
          "y" : 194
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147867,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 418,
          "y" : 191
        },
        "to" : {
          "x" : 437,
          "y" : 173
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 420,
          "y" : 183
        },
        "b" : {
          "x" : 418,
          "y" : 191
        },
        "c" : {
          "x" : 426,
          "y" : 189
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 426,
          "y" : 189
        }
      }
    } ]
  }, {
    "id" : 147871,
    "reactomeId" : 10505865,
    "displayName" : "UBE2I",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 520,
      "y" : 202
    },
    "minX" : 437,
    "maxX" : 557,
    "minY" : 173,
    "maxY" : 215,
    "prop" : {
      "x" : 490,
      "y" : 189,
      "width" : 61,
      "height" : 26
    },
    "textPosition" : {
      "x" : 498,
      "y" : 191
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 551,
          "y" : 189
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 551,
          "y" : 189
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147867,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 487,
          "y" : 191
        },
        "to" : {
          "x" : 437,
          "y" : 173
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 456,
            "y" : 176
          },
          "b" : {
            "x" : 468,
            "y" : 188
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 462,
            "y" : 182
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 479,
          "y" : 192
        },
        "b" : {
          "x" : 487,
          "y" : 191
        },
        "c" : {
          "x" : 482,
          "y" : 185
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 482,
          "y" : 185
        }
      }
    } ]
  }, {
    "id" : 147868,
    "reactomeId" : 10510745,
    "displayName" : "IKBKG",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 362,
      "y" : 85
    },
    "minX" : 328,
    "maxX" : 435,
    "minY" : 66,
    "maxY" : 120,
    "prop" : {
      "x" : 328,
      "y" : 72,
      "width" : 68,
      "height" : 27
    },
    "textPosition" : {
      "x" : 341,
      "y" : 75
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 396,
          "y" : 72
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 396,
          "y" : 72
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147867,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 390,
          "y" : 102
        },
        "to" : {
          "x" : 435,
          "y" : 120
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 147869,
    "reactomeId" : 10505873,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 492,
      "y" : 85
    },
    "minX" : 426,
    "maxX" : 565,
    "minY" : 66,
    "maxY" : 120,
    "prop" : {
      "x" : 426,
      "y" : 72,
      "width" : 133,
      "height" : 27
    },
    "textPosition" : {
      "x" : 432,
      "y" : 78
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 559,
          "y" : 72
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 559,
          "y" : 72
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147867,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 470,
          "y" : 102
        },
        "to" : {
          "x" : 435,
          "y" : 120
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 446,
            "y" : 105
          },
          "b" : {
            "x" : 458,
            "y" : 117
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 452,
            "y" : 111
          }
        }
      }
    } ]
  }, {
    "id" : 147874,
    "reactomeId" : 10510551,
    "displayName" : "NFKBIA",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 77,
      "y" : 300
    },
    "minX" : 46,
    "maxX" : 132,
    "minY" : 281,
    "maxY" : 340,
    "prop" : {
      "x" : 46,
      "y" : 287,
      "width" : 63,
      "height" : 26
    },
    "textPosition" : {
      "x" : 52,
      "y" : 289
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 109,
          "y" : 287
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 109,
          "y" : 287
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147873,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 94,
          "y" : 316
        },
        "to" : {
          "x" : 132,
          "y" : 340
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 147875,
    "reactomeId" : 10505873,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 213,
      "y" : 297
    },
    "minX" : 132,
    "maxX" : 288,
    "minY" : 278,
    "maxY" : 361,
    "prop" : {
      "x" : 145,
      "y" : 284,
      "width" : 137,
      "height" : 27
    },
    "textPosition" : {
      "x" : 153,
      "y" : 290
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 282,
          "y" : 284
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 282,
          "y" : 284
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147873,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 187,
          "y" : 314
        },
        "to" : {
          "x" : 132,
          "y" : 340
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 147873,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 196,
          "y" : 314
        },
        "to" : {
          "x" : 146,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 142,
          "y" : 357
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 142,
          "y" : 357
        }
      }
    } ]
  }, {
    "id" : 147872,
    "reactomeId" : 10448270,
    "displayName" : "PIAS4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 511,
      "y" : 147
    },
    "minX" : 443,
    "maxX" : 549,
    "minY" : 130,
    "maxY" : 158,
    "prop" : {
      "x" : 479,
      "y" : 136,
      "width" : 64,
      "height" : 22
    },
    "textPosition" : {
      "x" : 489,
      "y" : 136
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 543,
          "y" : 136
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 543,
          "y" : 136
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147867,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 476,
          "y" : 148
        },
        "to" : {
          "x" : 451,
          "y" : 149
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 447,
          "y" : 149
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 447,
          "y" : 149
        }
      }
    } ]
  }, {
    "id" : 147879,
    "reactomeId" : 10510770,
    "displayName" : "NFKB2_tv2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 664,
      "y" : 115
    },
    "minX" : 613,
    "maxX" : 722,
    "minY" : 95,
    "maxY" : 195,
    "prop" : {
      "x" : 613,
      "y" : 101,
      "width" : 103,
      "height" : 28
    },
    "textPosition" : {
      "x" : 628,
      "y" : 104
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 716,
          "y" : 101
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 716,
          "y" : 101
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147878,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 668,
          "y" : 132
        },
        "to" : {
          "x" : 691,
          "y" : 195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 147876,
    "reactomeId" : 10510554,
    "displayName" : "NFKBIA",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 106,
      "y" : 437
    },
    "minX" : 49,
    "maxX" : 170,
    "minY" : 393,
    "maxY" : 460,
    "prop" : {
      "x" : 49,
      "y" : 414,
      "width" : 115,
      "height" : 46
    },
    "textPosition" : {
      "x" : 81,
      "y" : 426
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 164,
          "y" : 414
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 164,
          "y" : 414
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147873,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 119,
          "y" : 411
        },
        "to" : {
          "x" : 131,
          "y" : 393
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 120,
          "y" : 403
        },
        "b" : {
          "x" : 119,
          "y" : 411
        },
        "c" : {
          "x" : 126,
          "y" : 407
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 126,
          "y" : 407
        }
      }
    } ]
  }, {
    "id" : 147877,
    "reactomeId" : 10505865,
    "displayName" : "UBE2I",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 216,
      "y" : 440
    },
    "minX" : 131,
    "maxX" : 252,
    "minY" : 393,
    "maxY" : 453,
    "prop" : {
      "x" : 186,
      "y" : 427,
      "width" : 60,
      "height" : 26
    },
    "textPosition" : {
      "x" : 194,
      "y" : 429
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 246,
          "y" : 427
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 246,
          "y" : 427
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147873,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 192,
          "y" : 424
        },
        "to" : {
          "x" : 131,
          "y" : 393
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 184,
          "y" : 424
        },
        "b" : {
          "x" : 192,
          "y" : 424
        },
        "c" : {
          "x" : 188,
          "y" : 417
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 188,
          "y" : 417
        }
      }
    } ]
  }, {
    "id" : 147882,
    "reactomeId" : 10510782,
    "displayName" : "NFKB2_tv2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 685,
      "y" : 401
    },
    "minX" : 622,
    "maxX" : 755,
    "minY" : 285,
    "maxY" : 431,
    "prop" : {
      "x" : 622,
      "y" : 371,
      "width" : 127,
      "height" : 60
    },
    "textPosition" : {
      "x" : 649,
      "y" : 390
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 749,
          "y" : 371
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 749,
          "y" : 371
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147878,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 686,
          "y" : 368
        },
        "to" : {
          "x" : 691,
          "y" : 285
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 682,
          "y" : 361
        },
        "b" : {
          "x" : 686,
          "y" : 368
        },
        "c" : {
          "x" : 690,
          "y" : 361
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 690,
          "y" : 361
        }
      }
    } ]
  }, {
    "id" : 147880,
    "reactomeId" : 10510776,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 795,
      "y" : 68
    },
    "minX" : 691,
    "maxX" : 868,
    "minY" : 48,
    "maxY" : 239,
    "prop" : {
      "x" : 728,
      "y" : 54,
      "width" : 134,
      "height" : 29
    },
    "textPosition" : {
      "x" : 735,
      "y" : 62
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 862,
          "y" : 54
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 862,
          "y" : 54
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147878,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 783,
          "y" : 86
        },
        "to" : {
          "x" : 691,
          "y" : 195
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 731,
            "y" : 134
          },
          "b" : {
            "x" : 743,
            "y" : 146
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 737,
            "y" : 140
          }
        }
      }
    }, {
      "edgeId" : 147878,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 786,
          "y" : 86
        },
        "to" : {
          "x" : 699,
          "y" : 231
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 697,
          "y" : 235
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 697,
          "y" : 235
        }
      }
    } ]
  }, {
    "id" : 147881,
    "reactomeId" : 10510516,
    "displayName" : "UBE2I",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 763,
      "y" : 340
    },
    "minX" : 691,
    "maxX" : 798,
    "minY" : 285,
    "maxY" : 353,
    "prop" : {
      "x" : 734,
      "y" : 327,
      "width" : 58,
      "height" : 26
    },
    "textPosition" : {
      "x" : 741,
      "y" : 329
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 792,
          "y" : 327
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 792,
          "y" : 327
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147878,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 745,
          "y" : 324
        },
        "to" : {
          "x" : 691,
          "y" : 285
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 712,
            "y" : 298
          },
          "b" : {
            "x" : 724,
            "y" : 310
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 718,
            "y" : 304
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 737,
          "y" : 323
        },
        "b" : {
          "x" : 745,
          "y" : 324
        },
        "c" : {
          "x" : 742,
          "y" : 317
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 742,
          "y" : 317
        }
      }
    } ]
  }, {
    "id" : 147886,
    "reactomeId" : 10510814,
    "displayName" : "SUMO3-RELA:SUMO3-RELA:DNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 377,
      "y" : 439
    },
    "minX" : 269,
    "maxX" : 492,
    "minY" : 388,
    "maxY" : 452,
    "prop" : {
      "x" : 269,
      "y" : 426,
      "width" : 217,
      "height" : 26
    },
    "textPosition" : {
      "x" : 278,
      "y" : 431
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 486,
          "y" : 426
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 486,
          "y" : 426
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147883,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 393,
          "y" : 423
        },
        "to" : {
          "x" : 441,
          "y" : 388
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 396,
          "y" : 416
        },
        "b" : {
          "x" : 393,
          "y" : 423
        },
        "c" : {
          "x" : 401,
          "y" : 422
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 401,
          "y" : 422
        }
      }
    } ]
  }, {
    "id" : 147887,
    "reactomeId" : 10505865,
    "displayName" : "UBE2I",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 535,
      "y" : 436
    },
    "minX" : 441,
    "maxX" : 574,
    "minY" : 388,
    "maxY" : 449,
    "prop" : {
      "x" : 503,
      "y" : 424,
      "width" : 65,
      "height" : 25
    },
    "textPosition" : {
      "x" : 513,
      "y" : 426
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 568,
          "y" : 424
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 568,
          "y" : 424
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147883,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 510,
          "y" : 421
        },
        "to" : {
          "x" : 441,
          "y" : 388
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 469,
            "y" : 398
          },
          "b" : {
            "x" : 481,
            "y" : 410
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 475,
            "y" : 404
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 502,
          "y" : 422
        },
        "b" : {
          "x" : 510,
          "y" : 421
        },
        "c" : {
          "x" : 505,
          "y" : 414
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 505,
          "y" : 414
        }
      }
    } ]
  }, {
    "id" : 147884,
    "reactomeId" : 10506053,
    "displayName" : "SUMO3:UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 511,
      "y" : 296
    },
    "minX" : 441,
    "maxX" : 573,
    "minY" : 276,
    "maxY" : 329,
    "prop" : {
      "x" : 456,
      "y" : 282,
      "width" : 111,
      "height" : 28
    },
    "textPosition" : {
      "x" : 465,
      "y" : 289
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 567,
          "y" : 282
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 567,
          "y" : 282
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147883,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 481,
          "y" : 313
        },
        "to" : {
          "x" : 441,
          "y" : 329
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 455,
            "y" : 315
          },
          "b" : {
            "x" : 467,
            "y" : 327
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 461,
            "y" : 321
          }
        }
      }
    } ]
  }, {
    "id" : 147885,
    "reactomeId" : 10510805,
    "displayName" : "RELA:RELA:DNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 367,
      "y" : 294
    },
    "minX" : 299,
    "maxX" : 441,
    "minY" : 275,
    "maxY" : 329,
    "prop" : {
      "x" : 299,
      "y" : 281,
      "width" : 136,
      "height" : 27
    },
    "textPosition" : {
      "x" : 316,
      "y" : 287
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 435,
          "y" : 281
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 435,
          "y" : 281
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147883,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 395,
          "y" : 311
        },
        "to" : {
          "x" : 441,
          "y" : 329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 147891,
    "reactomeId" : 10551024,
    "displayName" : "SUMO1,2-UBE2I",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 821,
      "y" : 166
    },
    "minX" : 775,
    "maxX" : 867,
    "minY" : 155,
    "maxY" : 178,
    "prop" : {
      "x" : 775,
      "y" : 155,
      "width" : 92,
      "height" : 23
    },
    "textPosition" : {
      "x" : 787,
      "y" : 149
    },
    "connectors" : [ ]
  }, {
    "id" : 147888,
    "reactomeId" : 10506876,
    "displayName" : "PIAS3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 530,
      "y" : 359
    },
    "minX" : 449,
    "maxX" : 566,
    "minY" : 341,
    "maxY" : 372,
    "prop" : {
      "x" : 501,
      "y" : 347,
      "width" : 59,
      "height" : 25
    },
    "textPosition" : {
      "x" : 509,
      "y" : 349
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 560,
          "y" : 347
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 560,
          "y" : 347
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 147883,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 498,
          "y" : 359
        },
        "to" : {
          "x" : 457,
          "y" : 359
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 453,
          "y" : 359
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 453,
          "y" : 359
        }
      }
    } ]
  }, {
    "id" : 147894,
    "reactomeId" : 10558999,
    "displayName" : "PKR-mediated signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 865,
      "y" : 473
    },
    "minX" : 810,
    "maxX" : 920,
    "minY" : 444,
    "maxY" : 503,
    "prop" : {
      "x" : 810,
      "y" : 444,
      "width" : 110,
      "height" : 59
    },
    "textPosition" : {
      "x" : 812,
      "y" : 452
    },
    "connectors" : [ ]
  }, {
    "id" : 147893,
    "reactomeId" : 10551031,
    "displayName" : "SUMO-EIF2AK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 863,
      "y" : 390
    },
    "minX" : 820,
    "maxX" : 913,
    "minY" : 361,
    "maxY" : 413,
    "prop" : {
      "x" : 820,
      "y" : 367,
      "width" : 87,
      "height" : 46
    },
    "textPosition" : {
      "x" : 833,
      "y" : 364
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 907,
          "y" : 367
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 907,
          "y" : 367
        }
      }
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 147873,
    "reactomeId" : 10510556,
    "displayName" : "SUMOylation of NFKBIA with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 133,
      "y" : 364
    },
    "minX" : 127,
    "maxX" : 139,
    "minY" : 340,
    "maxY" : 393,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 132,
        "y" : 340
      },
      "to" : {
        "x" : 133,
        "y" : 364
      }
    }, {
      "from" : {
        "x" : 133,
        "y" : 364
      },
      "to" : {
        "x" : 131,
        "y" : 393
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 127,
        "y" : 358
      },
      "b" : {
        "x" : 139,
        "y" : 370
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 133,
        "y" : 364
      }
    },
    "inputs" : [ {
      "id" : 147874,
      "points" : [ {
        "x" : 94,
        "y" : 316
      } ]
    }, {
      "id" : 147875,
      "points" : [ {
        "x" : 187,
        "y" : 314
      } ]
    } ],
    "outputs" : [ {
      "id" : 147876,
      "points" : [ {
        "x" : 119,
        "y" : 411
      } ]
    }, {
      "id" : 147877,
      "points" : [ {
        "x" : 192,
        "y" : 424
      } ]
    } ],
    "catalysts" : [ {
      "id" : 147875,
      "points" : [ {
        "x" : 196,
        "y" : 314
      } ]
    } ]
  }, {
    "id" : 147878,
    "reactomeId" : 10510785,
    "displayName" : "SUMOylation of NFKB2 with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 691,
      "y" : 245
    },
    "minX" : 685,
    "maxX" : 697,
    "minY" : 195,
    "maxY" : 285,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 691,
        "y" : 195
      },
      "to" : {
        "x" : 691,
        "y" : 245
      }
    }, {
      "from" : {
        "x" : 691,
        "y" : 245
      },
      "to" : {
        "x" : 691,
        "y" : 285
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 685,
        "y" : 239
      },
      "b" : {
        "x" : 697,
        "y" : 251
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 691,
        "y" : 245
      }
    },
    "inputs" : [ {
      "id" : 147879,
      "points" : [ {
        "x" : 668,
        "y" : 132
      } ]
    }, {
      "id" : 147880,
      "points" : [ {
        "x" : 783,
        "y" : 86
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 147881,
      "points" : [ {
        "x" : 745,
        "y" : 324
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 147882,
      "points" : [ {
        "x" : 686,
        "y" : 368
      } ]
    } ],
    "catalysts" : [ {
      "id" : 147880,
      "points" : [ {
        "x" : 786,
        "y" : 86
      } ]
    } ]
  }, {
    "id" : 147861,
    "reactomeId" : 10510768,
    "displayName" : "TOPORS SUMOylates IKBKE with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 177,
      "y" : 142
    },
    "minX" : 171,
    "maxX" : 183,
    "minY" : 121,
    "maxY" : 165,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 178,
        "y" : 121
      },
      "to" : {
        "x" : 177,
        "y" : 142
      }
    }, {
      "from" : {
        "x" : 177,
        "y" : 142
      },
      "to" : {
        "x" : 178,
        "y" : 165
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 171,
        "y" : 136
      },
      "b" : {
        "x" : 183,
        "y" : 148
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 177,
        "y" : 142
      }
    },
    "inputs" : [ {
      "id" : 147862,
      "points" : [ {
        "x" : 135,
        "y" : 103
      } ]
    }, {
      "id" : 147863,
      "points" : [ {
        "x" : 219,
        "y" : 100
      } ]
    } ],
    "outputs" : [ {
      "id" : 147864,
      "points" : [ {
        "x" : 226,
        "y" : 185
      } ]
    }, {
      "id" : 147865,
      "points" : [ {
        "x" : 143,
        "y" : 190
      } ]
    } ],
    "catalysts" : [ {
      "id" : 147866,
      "points" : [ {
        "x" : 145,
        "y" : 143
      } ]
    } ]
  }, {
    "id" : 147883,
    "reactomeId" : 10510816,
    "displayName" : "PIAS3 SUMOylates RELA with SUMO3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 441,
      "y" : 359
    },
    "minX" : 435,
    "maxX" : 447,
    "minY" : 329,
    "maxY" : 388,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 441,
        "y" : 329
      },
      "to" : {
        "x" : 441,
        "y" : 359
      }
    }, {
      "from" : {
        "x" : 441,
        "y" : 359
      },
      "to" : {
        "x" : 441,
        "y" : 388
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 435,
        "y" : 353
      },
      "b" : {
        "x" : 447,
        "y" : 365
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 441,
        "y" : 359
      }
    },
    "inputs" : [ {
      "id" : 147884,
      "points" : [ {
        "x" : 481,
        "y" : 313
      } ],
      "stoichiometry" : 12
    }, {
      "id" : 147885,
      "points" : [ {
        "x" : 395,
        "y" : 311
      } ]
    } ],
    "outputs" : [ {
      "id" : 147886,
      "points" : [ {
        "x" : 393,
        "y" : 423
      } ]
    }, {
      "id" : 147887,
      "points" : [ {
        "x" : 510,
        "y" : 421
      } ],
      "stoichiometry" : 12
    } ],
    "catalysts" : [ {
      "id" : 147888,
      "points" : [ {
        "x" : 498,
        "y" : 359
      } ]
    } ]
  }, {
    "id" : 147867,
    "reactomeId" : 10510751,
    "displayName" : "PIAS4 SUMOylates IKBKG with SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 435,
      "y" : 150
    },
    "minX" : 429,
    "maxX" : 441,
    "minY" : 120,
    "maxY" : 173,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 435,
        "y" : 120
      },
      "to" : {
        "x" : 435,
        "y" : 150
      }
    }, {
      "from" : {
        "x" : 435,
        "y" : 150
      },
      "to" : {
        "x" : 437,
        "y" : 173
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 429,
        "y" : 144
      },
      "b" : {
        "x" : 441,
        "y" : 156
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 435,
        "y" : 150
      }
    },
    "inputs" : [ {
      "id" : 147868,
      "points" : [ {
        "x" : 390,
        "y" : 102
      } ]
    }, {
      "id" : 147869,
      "points" : [ {
        "x" : 470,
        "y" : 102
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 147870,
      "points" : [ {
        "x" : 418,
        "y" : 191
      } ]
    }, {
      "id" : 147871,
      "points" : [ {
        "x" : 487,
        "y" : 191
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 147872,
      "points" : [ {
        "x" : 476,
        "y" : 148
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 147890,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 486,
      "y" : 276
    },
    "minX" : 0,
    "maxX" : 972,
    "minY" : 0,
    "maxY" : 553,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 972,
      "height" : 553
    },
    "textPosition" : {
      "x" : 13,
      "y" : 488
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 952,
      "height" : 533
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 147889, 147878, 147881, 147880, 147879, 147882, 147891, 147895, 147893, 147894, 147896 ]
  }, {
    "id" : 147889,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 307,
      "y" : 266
    },
    "minX" : 23,
    "maxX" : 592,
    "minY" : 33,
    "maxY" : 500,
    "prop" : {
      "x" : 23,
      "y" : 33,
      "width" : 569,
      "height" : 467
    },
    "textPosition" : {
      "x" : 43,
      "y" : 458
    },
    "insets" : {
      "x" : 33,
      "y" : 43,
      "width" : 549,
      "height" : 447
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 147861, 147862, 147863, 147864, 147866, 147867, 147868, 147873, 147874, 147875, 147877, 147872, 147883, 147884, 147885, 147886, 147888, 147887, 147871, 147869, 147865, 147870, 147876 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 147895,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 807,
      "y" : 117
    },
    "minX" : 798,
    "maxX" : 817,
    "minY" : 86,
    "maxY" : 149,
    "segments" : [ {
      "from" : {
        "x" : 798,
        "y" : 86
      },
      "to" : {
        "x" : 817,
        "y" : 149
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 801,
        "y" : 111
      },
      "b" : {
        "x" : 813,
        "y" : 123
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 807,
        "y" : 117
      }
    },
    "inputs" : [ {
      "id" : 147880
    } ],
    "outputs" : [ {
      "id" : 147891
    } ]
  }, {
    "id" : 147896,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 863,
      "y" : 428
    },
    "minX" : 857,
    "maxX" : 869,
    "minY" : 416,
    "maxY" : 441,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 863,
        "y" : 416
      },
      "to" : {
        "x" : 863,
        "y" : 441
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 859,
        "y" : 434
      },
      "b" : {
        "x" : 863,
        "y" : 441
      },
      "c" : {
        "x" : 867,
        "y" : 434
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 867,
        "y" : 434
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 857,
        "y" : 422
      },
      "b" : {
        "x" : 869,
        "y" : 434
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 863,
        "y" : 428
      }
    },
    "inputs" : [ {
      "id" : 147893
    } ],
    "outputs" : [ {
      "id" : 147894
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 972,
  "minY" : 0,
  "maxY" : 553,
  "disease" : false
}