{ "dbId" : 10557847, "stableId" : "R-SSC-1655829", "displayName" : "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "nodes" : [ { "id" : 169507, "reactomeId" : 10494941, "displayName" : "SREBP1A,1C,2:SCAP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 988, "y" : 63 }, "minX" : 911, "maxX" : 1071, "minY" : 46, "maxY" : 74, "prop" : { "x" : 911, "y" : 52, "width" : 154, "height" : 22 }, "textPosition" : { "x" : 922, "y" : 53 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1065, "y" : 52 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1065, "y" : 52 } } }, "connectors" : [ { "edgeId" : 169506, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 169520, "reactomeId" : 10469094, "displayName" : "KPNB1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 814, "y" : 521 }, "minX" : 777, "maxX" : 894, "minY" : 503, "maxY" : 586, "prop" : { "x" : 777, "y" : 509, "width" : 75, "height" : 24 }, "textPosition" : { "x" : 790, "y" : 510 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 852, "y" : 509 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 852, "y" : 509 } } }, "connectors" : [ { "edgeId" : 169519, "type" : "INPUT", "segments" : [ { "from" : { "x" : 847, "y" : 536 }, "to" : { "x" : 894, "y" : 550 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 169519, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 819, "y" : 536 }, "to" : { "x" : 842, "y" : 581 } }, { "from" : { "x" : 842, "y" : 581 }, "to" : { "x" : 879, "y" : 582 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 883, "y" : 582 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 883, "y" : 582 } } } ] }, { "id" : 169510, "reactomeId" : 10473531, "displayName" : "MBTPS1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1090, "y" : 126 }, "minX" : 997, "maxX" : 1130, "minY" : 108, "maxY" : 138, "prop" : { "x" : 1056, "y" : 114, "width" : 68, "height" : 24 }, "textPosition" : { "x" : 1061, "y" : 115 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1124, "y" : 114 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1124, "y" : 114 } } }, "connectors" : [ { "edgeId" : 169506, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1053, "y" : 124 }, "to" : { "x" : 1005, "y" : 123 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1001, "y" : 123 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1001, "y" : 123 } } } ] }, { "id" : 169508, "reactomeId" : 10494949, "displayName" : "SREBF1A,1C,2 cleaved by S1P", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 989, "y" : 263 }, "minX" : 888, "maxX" : 1090, "minY" : 174, "maxY" : 277, "prop" : { "x" : 888, "y" : 250, "width" : 202, "height" : 27 }, "textPosition" : { "x" : 892, "y" : 253 }, "connectors" : [ { "edgeId" : 169506, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 988, "y" : 244 }, "to" : { "x" : 988, "y" : 174 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 982, "y" : 203 }, "b" : { "x" : 994, "y" : 215 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 988, "y" : 209 } } }, "endShape" : { "a" : { "x" : 984, "y" : 237 }, "b" : { "x" : 988, "y" : 244 }, "c" : { "x" : 992, "y" : 237 }, "type" : "ARROW", "centre" : { "x" : 992, "y" : 237 } } }, { "edgeId" : 169511, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 169509, "reactomeId" : 10494939, "displayName" : "SCAP tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1085, "y" : 204 }, "minX" : 988, "maxX" : 1128, "minY" : 174, "maxY" : 222, "prop" : { "x" : 1048, "y" : 186, "width" : 74, "height" : 36 }, "textPosition" : { "x" : 1053, "y" : 187 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1122, "y" : 186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1122, "y" : 186 } } }, "connectors" : [ { "edgeId" : 169506, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1045, "y" : 192 }, "to" : { "x" : 988, "y" : 174 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1037, "y" : 194 }, "b" : { "x" : 1045, "y" : 192 }, "c" : { "x" : 1040, "y" : 186 }, "type" : "ARROW", "centre" : { "x" : 1040, "y" : 186 } } } ] }, { "id" : 169515, "reactomeId" : 10494913, "displayName" : "SREBP1A,1C,2:Importin beta-1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 896, "y" : 631 }, "minX" : 788, "maxX" : 1010, "minY" : 613, "maxY" : 644, "prop" : { "x" : 788, "y" : 619, "width" : 216, "height" : 25 }, "textPosition" : { "x" : 798, "y" : 623 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1004, "y" : 619 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1004, "y" : 619 } } }, "connectors" : [ { "edgeId" : 169514, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 169519, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 169512, "reactomeId" : 10494909, "displayName" : "SREBF1A,1C,2 cleaved by S2P", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 990, "y" : 425 }, "minX" : 885, "maxX" : 1096, "minY" : 410, "maxY" : 473, "prop" : { "x" : 885, "y" : 410, "width" : 211, "height" : 31 }, "textPosition" : { "x" : 894, "y" : 415 }, "connectors" : [ { "edgeId" : 169511, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 169517, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 985, "y" : 461 }, "b" : { "x" : 997, "y" : 473 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 991, "y" : 467 } } } } ] }, { "id" : 169513, "reactomeId" : 10476672, "displayName" : "MBTPS2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1090, "y" : 327 }, "minX" : 996, "maxX" : 1125, "minY" : 311, "maxY" : 338, "prop" : { "x" : 1061, "y" : 317, "width" : 58, "height" : 21 }, "textPosition" : { "x" : 1061, "y" : 317 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1119, "y" : 317 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1119, "y" : 317 } } }, "connectors" : [ { "edgeId" : 169511, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1058, "y" : 327 }, "to" : { "x" : 1004, "y" : 327 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1000, "y" : 327 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1000, "y" : 327 } } } ] }, { "id" : 169518, "reactomeId" : 10494911, "displayName" : "SREBP1A,1C,2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 992, "y" : 524 }, "minX" : 894, "maxX" : 1077, "minY" : 506, "maxY" : 550, "prop" : { "x" : 914, "y" : 512, "width" : 157, "height" : 24 }, "textPosition" : { "x" : 925, "y" : 515 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1071, "y" : 512 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1071, "y" : 512 } } }, "connectors" : [ { "edgeId" : 169519, "type" : "INPUT", "segments" : [ { "from" : { "x" : 946, "y" : 539 }, "to" : { "x" : 894, "y" : 550 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 169517, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 169516, "reactomeId" : 10494925, "displayName" : "SREBP1A,1C,2:Importin beta-1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 465, "y" : 466 }, "minX" : 359, "maxX" : 577, "minY" : 448, "maxY" : 478, "prop" : { "x" : 359, "y" : 454, "width" : 212, "height" : 24 }, "textPosition" : { "x" : 367, "y" : 457 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 571, "y" : 454 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 571, "y" : 454 } } }, "connectors" : [ { "edgeId" : 169514, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 169506, "reactomeId" : 10494951, "displayName" : "S1P hydrolyzes SREBP1A,1C,2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 989, "y" : 123 }, "minX" : 983, "maxX" : 995, "minY" : 77, "maxY" : 174, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 988, "y" : 77 }, "to" : { "x" : 989, "y" : 123 } }, { "from" : { "x" : 989, "y" : 123 }, "to" : { "x" : 988, "y" : 174 } } ], "reactionShape" : { "a" : { "x" : 983, "y" : 117 }, "b" : { "x" : 995, "y" : 129 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 989, "y" : 123 } }, "inputs" : [ { "id" : 169507 } ], "outputs" : [ { "id" : 169508, "points" : [ { "x" : 988, "y" : 244 } ], "stoichiometry" : 4 }, { "id" : 169509, "points" : [ { "x" : 1045, "y" : 192 } ] } ], "catalysts" : [ { "id" : 169510, "points" : [ { "x" : 1053, "y" : 124 } ] } ] }, { "id" : 169511, "reactomeId" : 10494953, "displayName" : "S2P hydrolyzes SREBP1A,1C,2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 988, "y" : 327 }, "minX" : 982, "maxX" : 994, "minY" : 283, "maxY" : 404, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 988, "y" : 283 }, "to" : { "x" : 988, "y" : 327 } }, { "from" : { "x" : 988, "y" : 327 }, "to" : { "x" : 989, "y" : 404 } } ], "endShape" : { "a" : { "x" : 985, "y" : 397 }, "b" : { "x" : 989, "y" : 404 }, "c" : { "x" : 993, "y" : 397 }, "type" : "ARROW", "centre" : { "x" : 993, "y" : 397 } }, "reactionShape" : { "a" : { "x" : 982, "y" : 321 }, "b" : { "x" : 994, "y" : 333 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 988, "y" : 327 } }, "inputs" : [ { "id" : 169508 } ], "outputs" : [ { "id" : 169512 } ], "catalysts" : [ { "id" : 169513, "points" : [ { "x" : 1058, "y" : 327 } ] } ] }, { "id" : 169514, "reactomeId" : 10494927, "displayName" : "SREBP1A,1C,2 translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 722, "y" : 468 }, "minX" : 574, "maxX" : 785, "minY" : 462, "maxY" : 629, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 785, "y" : 629 }, "to" : { "x" : 766, "y" : 629 } }, { "from" : { "x" : 766, "y" : 629 }, "to" : { "x" : 722, "y" : 468 } }, { "from" : { "x" : 722, "y" : 468 }, "to" : { "x" : 574, "y" : 466 } } ], "endShape" : { "a" : { "x" : 581, "y" : 462 }, "b" : { "x" : 574, "y" : 466 }, "c" : { "x" : 581, "y" : 470 }, "type" : "ARROW", "centre" : { "x" : 581, "y" : 470 } }, "reactionShape" : { "a" : { "x" : 716, "y" : 462 }, "b" : { "x" : 728, "y" : 474 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 722, "y" : 468 } }, "inputs" : [ { "id" : 169515 } ], "outputs" : [ { "id" : 169516 } ] }, { "id" : 169519, "reactomeId" : 10500275, "displayName" : "SREBP1A,1C,2 binds Importin beta-1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 895, "y" : 582 }, "minX" : 889, "maxX" : 901, "minY" : 550, "maxY" : 616, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 894, "y" : 550 }, "to" : { "x" : 895, "y" : 582 } }, { "from" : { "x" : 895, "y" : 582 }, "to" : { "x" : 895, "y" : 616 } } ], "endShape" : { "a" : { "x" : 891, "y" : 609 }, "b" : { "x" : 895, "y" : 616 }, "c" : { "x" : 899, "y" : 609 }, "type" : "ARROW", "centre" : { "x" : 899, "y" : 609 } }, "reactionShape" : { "a" : { "x" : 889, "y" : 576 }, "b" : { "x" : 901, "y" : 588 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 895, "y" : 582 } }, "inputs" : [ { "id" : 169520, "points" : [ { "x" : 847, "y" : 536 } ] }, { "id" : 169518, "points" : [ { "x" : 946, "y" : 539 } ] } ], "outputs" : [ { "id" : 169515 } ], "catalysts" : [ { "id" : 169520, "points" : [ { "x" : 819, "y" : 536 }, { "x" : 842, "y" : 581 } ] } ] }, { "id" : 169517, "reactomeId" : 10500272, "displayName" : "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 992, "y" : 487 }, "minX" : 986, "maxX" : 998, "minY" : 447, "maxY" : 509, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 990, "y" : 447 }, "to" : { "x" : 992, "y" : 487 } }, { "from" : { "x" : 992, "y" : 487 }, "to" : { "x" : 992, "y" : 509 } } ], "endShape" : { "a" : { "x" : 988, "y" : 502 }, "b" : { "x" : 992, "y" : 509 }, "c" : { "x" : 996, "y" : 502 }, "type" : "ARROW", "centre" : { "x" : 996, "y" : 502 } }, "reactionShape" : { "c" : { "x" : 992, "y" : 487 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 992, "y" : 487 } }, "inputs" : [ { "id" : 169512, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 169518 } ] } ], "compartments" : [ { "id" : 169522, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 402, "y" : 574 }, "minX" : 78, "maxX" : 727, "minY" : 430, "maxY" : 719, "prop" : { "x" : 78, "y" : 430, "width" : 649, "height" : 289 }, "textPosition" : { "x" : 570, "y" : 662 }, "insets" : { "x" : 88, "y" : 440, "width" : 629, "height" : 269 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 169516, 169514 ] }, { "id" : 169523, "reactomeId" : 12045, "displayName" : "endoplasmic reticulum membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 378, "y" : 205 }, "minX" : 19, "maxX" : 737, "minY" : 18, "maxY" : 392, "prop" : { "x" : 19, "y" : 18, "width" : 718, "height" : 374 }, "textPosition" : { "x" : 26, "y" : 349 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 169521, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 632, "y" : 384 }, "minX" : 0, "maxX" : 1264, "minY" : 0, "maxY" : 769, "prop" : { "x" : 0, "y" : 0, "width" : 1264, "height" : 769 }, "textPosition" : { "x" : 29, "y" : 721 }, "insets" : { "x" : 10, "y" : 10, "width" : 1244, "height" : 749 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 169522, 169523, 169524, 169515, 169517, 169518, 169519, 169512, 169520 ] }, { "id" : 169524, "reactomeId" : 20699, "displayName" : "Golgi membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 971, "y" : 203 }, "minX" : 780, "maxX" : 1163, "minY" : 27, "maxY" : 379, "prop" : { "x" : 780, "y" : 27, "width" : 383, "height" : 352 }, "textPosition" : { "x" : 783, "y" : 341 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 169507, 169506, 169508, 169509, 169510, 169511, 169513 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ ], "minX" : 0, "maxX" : 1264, "minY" : 0, "maxY" : 769, "disease" : false }