{ "dbId" : 10556899, "stableId" : "R-SSC-202131", "displayName" : "Metabolism of nitric oxide: NOS3 activation and regulation", "nodes" : [ { "id" : 178627, "reactomeId" : 5693375, "displayName" : "ADMA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 969, "y" : 622 }, "minX" : 943, "maxX" : 996, "minY" : 573, "maxY" : 637, "prop" : { "x" : 943, "y" : 607, "width" : 52, "height" : 30 }, "textPosition" : { "x" : 947, "y" : 611 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 990, "y" : 612 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 990, "y" : 612 } } }, "connectors" : [ { "edgeId" : 178626, "type" : "INPUT", "segments" : [ { "from" : { "x" : 969, "y" : 604 }, "to" : { "x" : 969, "y" : 573 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178624, "reactomeId" : 198816, "displayName" : "AscH-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1236, "y" : 498 }, "minX" : 1190, "maxX" : 1264, "minY" : 482, "maxY" : 530, "prop" : { "x" : 1210, "y" : 483, "width" : 53, "height" : 31 }, "textPosition" : { "x" : 1215, "y" : 488 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1258, "y" : 488 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1258, "y" : 488 } } }, "connectors" : [ { "edgeId" : 178618, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1212, "y" : 517 }, "to" : { "x" : 1190, "y" : 530 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1194, "y" : 523 }, "b" : { "x" : 1190, "y" : 530 }, "c" : { "x" : 1198, "y" : 530 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1198, "y" : 530 } } } ] }, { "id" : 178625, "reactomeId" : 10477735, "displayName" : "CYB5B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1124, "y" : 499 }, "minX" : 1101, "maxX" : 1174, "minY" : 482, "maxY" : 530, "prop" : { "x" : 1101, "y" : 488, "width" : 46, "height" : 23 }, "textPosition" : { "x" : 1104, "y" : 482 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1147, "y" : 488 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1147, "y" : 488 } } }, "connectors" : [ { "edgeId" : 178618, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1143, "y" : 514 }, "to" : { "x" : 1174, "y" : 530 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1166, "y" : 530 }, "b" : { "x" : 1174, "y" : 530 }, "c" : { "x" : 1170, "y" : 523 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1170, "y" : 523 } } } ] }, { "id" : 178630, "reactomeId" : 29968, "displayName" : "L-Cit", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1108, "y" : 641 }, "minX" : 1059, "maxX" : 1132, "minY" : 573, "maxY" : 656, "prop" : { "x" : 1086, "y" : 626, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1091, "y" : 630 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1126, "y" : 631 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1126, "y" : 631 } } }, "connectors" : [ { "edgeId" : 178626, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1097, "y" : 623 }, "to" : { "x" : 1059, "y" : 573 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1090, "y" : 620 }, "b" : { "x" : 1097, "y" : 623 }, "c" : { "x" : 1096, "y" : 615 }, "type" : "ARROW", "centre" : { "x" : 1096, "y" : 615 } } } ] }, { "id" : 178631, "reactomeId" : 10522228, "displayName" : "DDAH1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1021, "y" : 532 }, "minX" : 995, "maxX" : 1053, "minY" : 515, "maxY" : 565, "prop" : { "x" : 995, "y" : 521, "width" : 52, "height" : 23 }, "textPosition" : { "x" : 995, "y" : 522 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1047, "y" : 521 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1047, "y" : 521 } } }, "connectors" : [ { "edgeId" : 178626, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1021, "y" : 547 }, "to" : { "x" : 1021, "y" : 557 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1022, "y" : 561 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1022, "y" : 561 } } } ] }, { "id" : 178628, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 935, "y" : 541 }, "minX" : 914, "maxX" : 969, "minY" : 525, "maxY" : 573, "prop" : { "x" : 914, "y" : 526, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 918, "y" : 530 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 952, "y" : 531 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 952, "y" : 531 } } }, "connectors" : [ { "edgeId" : 178626, "type" : "INPUT", "segments" : [ { "from" : { "x" : 950, "y" : 559 }, "to" : { "x" : 969, "y" : 573 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 178629, "reactomeId" : 5693410, "displayName" : "DMA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1119, "y" : 576 }, "minX" : 1059, "maxX" : 1142, "minY" : 560, "maxY" : 591, "prop" : { "x" : 1097, "y" : 561, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 1101, "y" : 565 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1136, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1136, "y" : 566 } } }, "connectors" : [ { "edgeId" : 178626, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1094, "y" : 574 }, "to" : { "x" : 1059, "y" : 573 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1087, "y" : 578 }, "b" : { "x" : 1094, "y" : 574 }, "c" : { "x" : 1087, "y" : 570 }, "type" : "ARROW", "centre" : { "x" : 1087, "y" : 570 } } } ] }, { "id" : 178634, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1606, "y" : 482 }, "minX" : 1570, "maxX" : 1625, "minY" : 440, "maxY" : 497, "prop" : { "x" : 1588, "y" : 467, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1592, "y" : 471 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1619, "y" : 472 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1619, "y" : 472 } } }, "connectors" : [ { "edgeId" : 178632, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1593, "y" : 464 }, "to" : { "x" : 1570, "y" : 440 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 178635, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1623, "y" : 405 }, "minX" : 1570, "maxX" : 1654, "minY" : 389, "maxY" : 440, "prop" : { "x" : 1594, "y" : 390, "width" : 59, "height" : 30 }, "textPosition" : { "x" : 1598, "y" : 394 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1648, "y" : 395 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1648, "y" : 395 } } }, "connectors" : [ { "edgeId" : 178632, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1600, "y" : 423 }, "to" : { "x" : 1570, "y" : 440 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178633, "reactomeId" : 1497811, "displayName" : "sepiapterin", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1668, "y" : 440 }, "minX" : 1570, "maxX" : 1710, "minY" : 424, "maxY" : 455, "prop" : { "x" : 1627, "y" : 425, "width" : 82, "height" : 30 }, "textPosition" : { "x" : 1628, "y" : 429 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1704, "y" : 430 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1704, "y" : 430 } } }, "connectors" : [ { "edgeId" : 178632, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1624, "y" : 440 }, "to" : { "x" : 1570, "y" : 440 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178638, "reactomeId" : 10492397, "displayName" : "p-SPR dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1517, "y" : 392 }, "minX" : 1476, "maxX" : 1565, "minY" : 375, "maxY" : 432, "prop" : { "x" : 1476, "y" : 381, "width" : 83, "height" : 22 }, "textPosition" : { "x" : 1476, "y" : 382 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1559, "y" : 381 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1559, "y" : 381 } } }, "connectors" : [ { "edgeId" : 178632, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1516, "y" : 406 }, "to" : { "x" : 1516, "y" : 424 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1516, "y" : 428 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1516, "y" : 428 } } } ] }, { "id" : 178636, "reactomeId" : 1497857, "displayName" : "q-BH2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1336, "y" : 440 }, "minX" : 1316, "maxX" : 1466, "minY" : 424, "maxY" : 455, "prop" : { "x" : 1316, "y" : 425, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1320, "y" : 423 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1352, "y" : 430 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1352, "y" : 430 } } }, "connectors" : [ { "edgeId" : 178632, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1360, "y" : 440 }, "to" : { "x" : 1466, "y" : 440 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1367, "y" : 436 }, "b" : { "x" : 1360, "y" : 440 }, "c" : { "x" : 1367, "y" : 444 }, "type" : "ARROW", "centre" : { "x" : 1367, "y" : 444 } } } ] }, { "id" : 178637, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1424, "y" : 482 }, "minX" : 1394, "maxX" : 1466, "minY" : 440, "maxY" : 497, "prop" : { "x" : 1394, "y" : 467, "width" : 60, "height" : 30 }, "textPosition" : { "x" : 1398, "y" : 471 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1449, "y" : 472 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1449, "y" : 472 } } }, "connectors" : [ { "edgeId" : 178632, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1439, "y" : 464 }, "to" : { "x" : 1466, "y" : 440 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1442, "y" : 456 }, "b" : { "x" : 1439, "y" : 464 }, "c" : { "x" : 1447, "y" : 462 }, "type" : "ARROW", "centre" : { "x" : 1447, "y" : 462 } } } ] }, { "id" : 178586, "reactomeId" : 10467455, "displayName" : "2xPalmC-MyrG-NOS3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 533, "y" : 382 }, "minX" : 390, "maxX" : 591, "minY" : 329, "maxY" : 400, "prop" : { "x" : 481, "y" : 364, "width" : 104, "height" : 36 }, "textPosition" : { "x" : 484, "y" : 364 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 585, "y" : 364 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 585, "y" : 364 } } }, "connectors" : [ { "edgeId" : 178583, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 532, "y" : 361 }, "to" : { "x" : 532, "y" : 329 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 528, "y" : 354 }, "b" : { "x" : 532, "y" : 361 }, "c" : { "x" : 536, "y" : 354 }, "type" : "ARROW", "centre" : { "x" : 536, "y" : 354 } } }, { "edgeId" : 178589, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 390, "y" : 362 }, "b" : { "x" : 402, "y" : 374 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 396, "y" : 368 } } } } ] }, { "id" : 178587, "reactomeId" : 76194, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 401, "y" : 337 }, "minX" : 370, "maxX" : 532, "minY" : 321, "maxY" : 353, "prop" : { "x" : 370, "y" : 322, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 374, "y" : 327 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 427, "y" : 327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 427, "y" : 327 } } }, "connectors" : [ { "edgeId" : 178583, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 435, "y" : 335 }, "to" : { "x" : 532, "y" : 329 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 477, "y" : 326 }, "b" : { "x" : 489, "y" : 338 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 483, "y" : 332 } } }, "endShape" : { "a" : { "x" : 442, "y" : 331 }, "b" : { "x" : 435, "y" : 335 }, "c" : { "x" : 442, "y" : 339 }, "type" : "ARROW", "centre" : { "x" : 442, "y" : 339 } } } ] }, { "id" : 178651, "reactomeId" : 29870, "displayName" : "BH4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 963, "y" : 308 }, "minX" : 943, "maxX" : 985, "minY" : 292, "maxY" : 323, "prop" : { "x" : 943, "y" : 293, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 947, "y" : 297 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 979, "y" : 298 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 979, "y" : 298 } } }, "connectors" : [ ] }, { "id" : 178584, "reactomeId" : 200993, "displayName" : "PALM-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 442, "y" : 223 }, "minX" : 403, "maxX" : 491, "minY" : 207, "maxY" : 297, "prop" : { "x" : 403, "y" : 208, "width" : 78, "height" : 30 }, "textPosition" : { "x" : 408, "y" : 212 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 476, "y" : 213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 476, "y" : 213 } } }, "connectors" : [ { "edgeId" : 178583, "type" : "INPUT", "segments" : [ { "from" : { "x" : 451, "y" : 241 }, "to" : { "x" : 491, "y" : 297 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 465, "y" : 263 }, "b" : { "x" : 477, "y" : 275 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 471, "y" : 269 } } } } ] }, { "id" : 178585, "reactomeId" : 10466692, "displayName" : "MyrG-NOS3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 396, "y" : 297 }, "minX" : 357, "maxX" : 491, "minY" : 280, "maxY" : 308, "prop" : { "x" : 357, "y" : 286, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 358, "y" : 286 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 435, "y" : 286 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 435, "y" : 286 } } }, "connectors" : [ { "edgeId" : 178583, "type" : "INPUT", "segments" : [ { "from" : { "x" : 438, "y" : 297 }, "to" : { "x" : 491, "y" : 297 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178590, "reactomeId" : 10466680, "displayName" : "palmitoylated, myristoylated eNOS dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 83, "y" : 367 }, "minX" : 21, "maxX" : 176, "minY" : 273, "maxY" : 476, "prop" : { "x" : 21, "y" : 342, "width" : 125, "height" : 50 }, "textPosition" : { "x" : 33, "y" : 343 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 146, "y" : 342 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 146, "y" : 342 } } }, "connectors" : [ { "edgeId" : 178594, "type" : "INPUT", "segments" : [ { "from" : { "x" : 149, "y" : 388 }, "to" : { "x" : 176, "y" : 399 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178602, "type" : "INPUT", "segments" : [ { "from" : { "x" : 82, "y" : 339 }, "to" : { "x" : 82, "y" : 273 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178591, "type" : "INPUT", "segments" : [ { "from" : { "x" : 83, "y" : 395 }, "to" : { "x" : 83, "y" : 476 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178589, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178588, "reactomeId" : 10467459, "displayName" : "ZDHHC21", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 533, "y" : 244 }, "minX" : 500, "maxX" : 573, "minY" : 227, "maxY" : 289, "prop" : { "x" : 500, "y" : 233, "width" : 67, "height" : 22 }, "textPosition" : { "x" : 503, "y" : 227 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 567, "y" : 233 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 567, "y" : 233 } } }, "connectors" : [ { "edgeId" : 178583, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 532, "y" : 258 }, "to" : { "x" : 532, "y" : 281 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 532, "y" : 285 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 532, "y" : 285 } } } ] }, { "id" : 178658, "reactomeId" : 10557181, "displayName" : "Metabolism of cofactors", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1196, "y" : 209 }, "minX" : 1115, "maxX" : 1278, "minY" : 182, "maxY" : 237, "prop" : { "x" : 1115, "y" : 182, "width" : 163, "height" : 55 }, "textPosition" : { "x" : 1143, "y" : 188 }, "connectors" : [ ] }, { "id" : 178595, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 117, "y" : 445 }, "minX" : 96, "maxX" : 176, "minY" : 399, "maxY" : 461, "prop" : { "x" : 96, "y" : 430, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 100, "y" : 435 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 134, "y" : 435 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 134, "y" : 435 } } }, "connectors" : [ { "edgeId" : 178594, "type" : "INPUT", "segments" : [ { "from" : { "x" : 136, "y" : 427 }, "to" : { "x" : 176, "y" : 399 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 150, "y" : 407 }, "b" : { "x" : 162, "y" : 419 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 156, "y" : 413 } } } } ], "trivial" : true }, { "id" : 178592, "reactomeId" : 10466710, "displayName" : "CAV1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 248, "y" : 617 }, "minX" : 83, "maxX" : 275, "minY" : 476, "maxY" : 628, "prop" : { "x" : 228, "y" : 606, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 228, "y" : 606 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 269, "y" : 606 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 269, "y" : 606 } } }, "connectors" : [ { "edgeId" : 178591, "type" : "INPUT", "segments" : [ { "from" : { "x" : 246, "y" : 603 }, "to" : { "x" : 232, "y" : 476 } }, { "from" : { "x" : 232, "y" : 476 }, "to" : { "x" : 83, "y" : 476 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178591, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 245, "y" : 603 }, "to" : { "x" : 217, "y" : 502 } }, { "from" : { "x" : 217, "y" : 502 }, "to" : { "x" : 99, "y" : 497 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 95, "y" : 497 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 95, "y" : 497 } } } ] }, { "id" : 178593, "reactomeId" : 10466686, "displayName" : "eNOS:Caveolin-1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 84, "y" : 538 }, "minX" : 0, "maxX" : 149, "minY" : 95, "maxY" : 549, "prop" : { "x" : 26, "y" : 528, "width" : 117, "height" : 21 }, "textPosition" : { "x" : 29, "y" : 528 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 143, "y" : 528 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 143, "y" : 528 } } }, "connectors" : [ { "edgeId" : 178607, "type" : "INPUT", "segments" : [ { "from" : { "x" : 23, "y" : 538 }, "to" : { "x" : 2, "y" : 539 } }, { "from" : { "x" : 2, "y" : 539 }, "to" : { "x" : 0, "y" : 103 } }, { "from" : { "x" : 0, "y" : 103 }, "to" : { "x" : 39, "y" : 95 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178591, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178657, "reactomeId" : 10556175, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 474, "y" : 605 }, "minX" : 406, "maxX" : 543, "minY" : 581, "maxY" : 630, "prop" : { "x" : 406, "y" : 581, "width" : 137, "height" : 49 }, "textPosition" : { "x" : 407, "y" : 584 }, "connectors" : [ ] }, { "id" : 178598, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 263, "y" : 467 }, "minX" : 230, "maxX" : 282, "minY" : 399, "maxY" : 482, "prop" : { "x" : 245, "y" : 452, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 249, "y" : 456 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 276, "y" : 457 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 276, "y" : 457 } } }, "connectors" : [ { "edgeId" : 178594, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 255, "y" : 449 }, "to" : { "x" : 230, "y" : 399 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 236, "y" : 418 }, "b" : { "x" : 248, "y" : 430 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 242, "y" : 424 } } }, "endShape" : { "a" : { "x" : 248, "y" : 445 }, "b" : { "x" : 255, "y" : 449 }, "c" : { "x" : 255, "y" : 441 }, "type" : "ARROW", "centre" : { "x" : 255, "y" : 441 } } } ], "trivial" : true }, { "id" : 178599, "reactomeId" : 10467468, "displayName" : "LYPLA1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 197, "y" : 451 }, "minX" : 162, "maxX" : 238, "minY" : 408, "maxY" : 468, "prop" : { "x" : 162, "y" : 434, "width" : 70, "height" : 34 }, "textPosition" : { "x" : 169, "y" : 433 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 232, "y" : 434 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 232, "y" : 434 } } }, "connectors" : [ { "edgeId" : 178594, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 198, "y" : 431 }, "to" : { "x" : 199, "y" : 416 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 200, "y" : 412 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 200, "y" : 412 } } } ] }, { "id" : 178596, "reactomeId" : 10466694, "displayName" : "myristoylated eNOS dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 356, "y" : 453 }, "minX" : 230, "maxX" : 425, "minY" : 399, "maxY" : 471, "prop" : { "x" : 294, "y" : 435, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 309, "y" : 436 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 419, "y" : 435 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 419, "y" : 435 } } }, "connectors" : [ { "edgeId" : 178594, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 314, "y" : 432 }, "to" : { "x" : 230, "y" : 399 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 306, "y" : 433 }, "b" : { "x" : 314, "y" : 432 }, "c" : { "x" : 309, "y" : 426 }, "type" : "ARROW", "centre" : { "x" : 309, "y" : 426 } } }, { "edgeId" : 178600, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178597, "reactomeId" : 3632881, "displayName" : "PALM", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 334, "y" : 402 }, "minX" : 230, "maxX" : 359, "minY" : 386, "maxY" : 418, "prop" : { "x" : 310, "y" : 387, "width" : 48, "height" : 31 }, "textPosition" : { "x" : 314, "y" : 392 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 353, "y" : 392 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 353, "y" : 392 } } }, "connectors" : [ { "edgeId" : 178594, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 307, "y" : 401 }, "to" : { "x" : 230, "y" : 399 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 262, "y" : 394 }, "b" : { "x" : 274, "y" : 406 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 268, "y" : 400 } } }, "endShape" : { "a" : { "x" : 300, "y" : 405 }, "b" : { "x" : 307, "y" : 401 }, "c" : { "x" : 300, "y" : 397 }, "type" : "ARROW", "centre" : { "x" : 300, "y" : 397 } } } ] }, { "id" : 178603, "reactomeId" : 10467429, "displayName" : "NOSIP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 133, "y" : 274 }, "minX" : 82, "maxX" : 161, "minY" : 233, "maxY" : 285, "prop" : { "x" : 112, "y" : 263, "width" : 43, "height" : 22 }, "textPosition" : { "x" : 115, "y" : 257 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 155, "y" : 263 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 155, "y" : 263 } } }, "connectors" : [ { "edgeId" : 178602, "type" : "INPUT", "segments" : [ { "from" : { "x" : 109, "y" : 273 }, "to" : { "x" : 82, "y" : 273 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178602, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 129, "y" : 260 }, "to" : { "x" : 120, "y" : 238 } }, { "from" : { "x" : 120, "y" : 238 }, "to" : { "x" : 97, "y" : 237 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 93, "y" : 237 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 93, "y" : 237 } } } ] }, { "id" : 178601, "reactomeId" : 10466698, "displayName" : "myristoylated eNOS dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 535, "y" : 451 }, "minX" : 473, "maxX" : 604, "minY" : 427, "maxY" : 469, "prop" : { "x" : 473, "y" : 433, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 488, "y" : 434 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 598, "y" : 433 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 598, "y" : 433 } } }, "connectors" : [ { "edgeId" : 178600, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178606, "reactomeId" : 10467502, "displayName" : "eNOS:NOSIP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 535, "y" : 179 }, "minX" : 496, "maxX" : 580, "minY" : 162, "maxY" : 190, "prop" : { "x" : 496, "y" : 168, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 512, "y" : 155 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 574, "y" : 168 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 574, "y" : 168 } } }, "connectors" : [ { "edgeId" : 178605, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178604, "reactomeId" : 10467431, "displayName" : "eNOS:NOSIP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 82, "y" : 181 }, "minX" : 38, "maxX" : 312, "minY" : 139, "maxY" : 192, "prop" : { "x" : 38, "y" : 170, "width" : 88, "height" : 22 }, "textPosition" : { "x" : 40, "y" : 171 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 126, "y" : 170 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 126, "y" : 170 } } }, "connectors" : [ { "edgeId" : 178602, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178605, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178605, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 129, "y" : 172 }, "to" : { "x" : 307, "y" : 139 } }, { "from" : { "x" : 307, "y" : 139 }, "to" : { "x" : 308, "y" : 164 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 308, "y" : 168 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 308, "y" : 168 } } } ] }, { "id" : 178611, "reactomeId" : 10463132, "displayName" : "DNM2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 155, "y" : 57 }, "minX" : 133, "maxX" : 184, "minY" : 28, "maxY" : 68, "prop" : { "x" : 133, "y" : 46, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 133, "y" : 46 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 178, "y" : 46 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 178, "y" : 46 } } }, "connectors" : [ { "edgeId" : 178610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 165, "y" : 43 }, "to" : { "x" : 183, "y" : 28 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178608, "reactomeId" : 10467440, "displayName" : "NOSTRIN homotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 73, "y" : 135 }, "minX" : 31, "maxX" : 121, "minY" : 85, "maxY" : 153, "prop" : { "x" : 31, "y" : 117, "width" : 84, "height" : 36 }, "textPosition" : { "x" : 33, "y" : 118 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 115, "y" : 117 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 115, "y" : 117 } } }, "connectors" : [ { "edgeId" : 178607, "type" : "INPUT", "segments" : [ { "from" : { "x" : 57, "y" : 114 }, "to" : { "x" : 39, "y" : 95 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178607, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 86, "y" : 114 }, "to" : { "x" : 109, "y" : 88 } }, { "from" : { "x" : 109, "y" : 88 }, "to" : { "x" : 79, "y" : 89 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 75, "y" : 89 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 75, "y" : 89 } } } ] }, { "id" : 178609, "reactomeId" : 10467493, "displayName" : "eNOS:Caveolin-1:NOSTRIN complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 63, "y" : 35 }, "minX" : 6, "maxX" : 237, "minY" : 0, "maxY" : 53, "prop" : { "x" : 6, "y" : 17, "width" : 114, "height" : 36 }, "textPosition" : { "x" : 6, "y" : 4 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 120, "y" : 17 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 120, "y" : 17 } } }, "connectors" : [ { "edgeId" : 178607, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178610, "type" : "INPUT", "segments" : [ { "from" : { "x" : 123, "y" : 31 }, "to" : { "x" : 183, "y" : 28 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178610, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 123, "y" : 23 }, "to" : { "x" : 232, "y" : 0 } }, { "from" : { "x" : 232, "y" : 0 }, "to" : { "x" : 233, "y" : 33 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 233, "y" : 37 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 233, "y" : 37 } } } ] }, { "id" : 178614, "reactomeId" : 10467446, "displayName" : "WASL", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 394, "y" : 104 }, "minX" : 366, "maxX" : 428, "minY" : 49, "maxY" : 115, "prop" : { "x" : 366, "y" : 93, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 373, "y" : 93 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 422, "y" : 93 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 422, "y" : 93 } } }, "connectors" : [ { "edgeId" : 178613, "type" : "INPUT", "segments" : [ { "from" : { "x" : 397, "y" : 90 }, "to" : { "x" : 411, "y" : 49 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178615, "reactomeId" : 10467450, "displayName" : "eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 528, "y" : 50 }, "minX" : 462, "maxX" : 601, "minY" : 19, "maxY" : 75, "prop" : { "x" : 462, "y" : 25, "width" : 133, "height" : 50 }, "textPosition" : { "x" : 462, "y" : 26 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 595, "y" : 25 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 595, "y" : 25 } } }, "connectors" : [ { "edgeId" : 178613, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178616, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178612, "reactomeId" : 10467442, "displayName" : "eNOS:Caveolin-1:NOSTRIN:Dynamin-2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 325, "y" : 48 }, "minX" : 259, "maxX" : 434, "minY" : 2, "maxY" : 67, "prop" : { "x" : 259, "y" : 29, "width" : 132, "height" : 38 }, "textPosition" : { "x" : 260, "y" : 32 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 391, "y" : 29 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 391, "y" : 29 } } }, "connectors" : [ { "edgeId" : 178610, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178613, "type" : "INPUT", "segments" : [ { "from" : { "x" : 394, "y" : 48 }, "to" : { "x" : 411, "y" : 49 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178613, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 368, "y" : 26 }, "to" : { "x" : 431, "y" : 2 } }, { "from" : { "x" : 431, "y" : 2 }, "to" : { "x" : 430, "y" : 32 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 430, "y" : 36 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 430, "y" : 36 } } } ] }, { "id" : 178619, "reactomeId" : 202124, "displayName" : "NO", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1182, "y" : 681 }, "minX" : 1165, "maxX" : 1201, "minY" : 595, "maxY" : 696, "prop" : { "x" : 1165, "y" : 666, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1169, "y" : 670 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1195, "y" : 671 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1195, "y" : 671 } } }, "connectors" : [ { "edgeId" : 178618, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1182, "y" : 663 }, "to" : { "x" : 1182, "y" : 595 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178617, "reactomeId" : 10467489, "displayName" : "eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 733, "y" : 141 }, "minX" : 673, "maxX" : 800, "minY" : 103, "maxY" : 173, "prop" : { "x" : 673, "y" : 109, "width" : 121, "height" : 64 }, "textPosition" : { "x" : 673, "y" : 124 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 794, "y" : 109 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 794, "y" : 109 } } }, "connectors" : [ { "edgeId" : 178616, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 178622, "reactomeId" : 432031, "displayName" : "NO3-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1182, "y" : 418 }, "minX" : 1159, "maxX" : 1207, "minY" : 402, "maxY" : 478, "prop" : { "x" : 1159, "y" : 403, "width" : 47, "height" : 30 }, "textPosition" : { "x" : 1163, "y" : 407 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1201, "y" : 408 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1201, "y" : 408 } } }, "connectors" : [ { "edgeId" : 178618, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1181, "y" : 436 }, "to" : { "x" : 1181, "y" : 478 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1185, "y" : 443 }, "b" : { "x" : 1181, "y" : 436 }, "c" : { "x" : 1177, "y" : 443 }, "type" : "ARROW", "centre" : { "x" : 1177, "y" : 443 } } } ] }, { "id" : 178623, "reactomeId" : 10513194, "displayName" : "CYBG(Fe3+) dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1101, "y" : 428 }, "minX" : 1062, "maxX" : 1181, "minY" : 403, "maxY" : 478, "prop" : { "x" : 1062, "y" : 409, "width" : 79, "height" : 38 }, "textPosition" : { "x" : 1074, "y" : 398 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1141, "y" : 409 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1141, "y" : 409 } } }, "connectors" : [ { "edgeId" : 178618, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1131, "y" : 450 }, "to" : { "x" : 1181, "y" : 478 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1139, "y" : 450 }, "b" : { "x" : 1131, "y" : 450 }, "c" : { "x" : 1135, "y" : 457 }, "type" : "ARROW", "centre" : { "x" : 1135, "y" : 457 } } } ] }, { "id" : 178620, "reactomeId" : 10513186, "displayName" : "CYGB(Fe2+) dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1246, "y" : 594 }, "minX" : 1182, "maxX" : 1293, "minY" : 530, "maxY" : 612, "prop" : { "x" : 1205, "y" : 577, "width" : 82, "height" : 35 }, "textPosition" : { "x" : 1218, "y" : 563 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1287, "y" : 577 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1287, "y" : 577 } } }, "connectors" : [ { "edgeId" : 178618, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1202, "y" : 594 }, "to" : { "x" : 1182, "y" : 595 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 178618, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1245, "y" : 574 }, "to" : { "x" : 1245, "y" : 534 } }, { "from" : { "x" : 1245, "y" : 534 }, "to" : { "x" : 1198, "y" : 534 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1194, "y" : 534 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1194, "y" : 534 } } } ] }, { "id" : 178621, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1235, "y" : 649 }, "minX" : 1182, "maxX" : 1253, "minY" : 595, "maxY" : 664, "prop" : { "x" : 1218, "y" : 634, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 1222, "y" : 638 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1247, "y" : 639 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1247, "y" : 639 } } }, "connectors" : [ { "edgeId" : 178618, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1220, "y" : 631 }, "to" : { "x" : 1182, "y" : 595 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true } ], "edges" : [ { "id" : 178594, "reactomeId" : 10467471, "displayName" : "Depalmitoylation of eNOS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 201, "y" : 400 }, "minX" : 176, "maxX" : 230, "minY" : 394, "maxY" : 406, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 176, "y" : 399 }, "to" : { "x" : 201, "y" : 400 } }, { "from" : { "x" : 201, "y" : 400 }, "to" : { "x" : 230, "y" : 399 } } ], "reactionShape" : { "a" : { "x" : 195, "y" : 394 }, "b" : { "x" : 207, "y" : 406 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 201, "y" : 400 } }, "inputs" : [ { "id" : 178590, "points" : [ { "x" : 149, "y" : 388 } ] }, { "id" : 178595, "points" : [ { "x" : 136, "y" : 427 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 178596, "points" : [ { "x" : 314, "y" : 432 } ] }, { "id" : 178597, "points" : [ { "x" : 307, "y" : 401 } ], "stoichiometry" : 4 }, { "id" : 178598, "points" : [ { "x" : 255, "y" : 449 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 178599, "points" : [ { "x" : 198, "y" : 431 } ] } ] }, { "id" : 178626, "reactomeId" : 10522231, "displayName" : "DDAH1 hydrolyses ADMA to DMA and L-Cit", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1022, "y" : 573 }, "minX" : 969, "maxX" : 1059, "minY" : 567, "maxY" : 579, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 969, "y" : 573 }, "to" : { "x" : 1022, "y" : 573 } }, { "from" : { "x" : 1022, "y" : 573 }, "to" : { "x" : 1059, "y" : 573 } } ], "reactionShape" : { "a" : { "x" : 1016, "y" : 567 }, "b" : { "x" : 1028, "y" : 579 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1022, "y" : 573 } }, "inputs" : [ { "id" : 178627, "points" : [ { "x" : 969, "y" : 604 } ] }, { "id" : 178628, "points" : [ { "x" : 950, "y" : 559 } ] } ], "outputs" : [ { "id" : 178629, "points" : [ { "x" : 1094, "y" : 574 } ] }, { "id" : 178630, "points" : [ { "x" : 1097, "y" : 623 } ] } ], "catalysts" : [ { "id" : 178631, "points" : [ { "x" : 1021, "y" : 547 } ] } ] }, { "id" : 178602, "reactomeId" : 10467434, "displayName" : "eNOS binds NOSIP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 81, "y" : 237 }, "minX" : 75, "maxX" : 87, "minY" : 195, "maxY" : 273, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 82, "y" : 273 }, "to" : { "x" : 81, "y" : 237 } }, { "from" : { "x" : 81, "y" : 237 }, "to" : { "x" : 81, "y" : 195 } } ], "endShape" : { "a" : { "x" : 85, "y" : 202 }, "b" : { "x" : 81, "y" : 195 }, "c" : { "x" : 77, "y" : 202 }, "type" : "ARROW", "centre" : { "x" : 77, "y" : 202 } }, "reactionShape" : { "a" : { "x" : 75, "y" : 231 }, "b" : { "x" : 87, "y" : 243 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 81, "y" : 237 } }, "inputs" : [ { "id" : 178603, "points" : [ { "x" : 109, "y" : 273 } ] }, { "id" : 178590, "points" : [ { "x" : 82, "y" : 339 } ] } ], "outputs" : [ { "id" : 178604 } ], "catalysts" : [ { "id" : 178603, "points" : [ { "x" : 129, "y" : 260 }, { "x" : 120, "y" : 238 } ] } ] }, { "id" : 178632, "reactomeId" : 10492907, "displayName" : "Salvage - Sepiapterin is reduced to q-BH2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1516, "y" : 440 }, "minX" : 1466, "maxX" : 1570, "minY" : 434, "maxY" : 446, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1570, "y" : 440 }, "to" : { "x" : 1516, "y" : 440 } }, { "from" : { "x" : 1516, "y" : 440 }, "to" : { "x" : 1466, "y" : 440 } } ], "reactionShape" : { "a" : { "x" : 1510, "y" : 434 }, "b" : { "x" : 1522, "y" : 446 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1516, "y" : 440 } }, "inputs" : [ { "id" : 178633, "points" : [ { "x" : 1624, "y" : 440 } ] }, { "id" : 178634, "points" : [ { "x" : 1593, "y" : 464 } ] }, { "id" : 178635, "points" : [ { "x" : 1600, "y" : 423 } ] } ], "outputs" : [ { "id" : 178636, "points" : [ { "x" : 1360, "y" : 440 } ] }, { "id" : 178637, "points" : [ { "x" : 1439, "y" : 464 } ] } ], "catalysts" : [ { "id" : 178638, "points" : [ { "x" : 1516, "y" : 406 } ] } ] }, { "id" : 178600, "reactomeId" : 10466700, "displayName" : "depalmitoylated eNOS translocates from plasma membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 444, "y" : 452 }, "minX" : 422, "maxX" : 470, "minY" : 446, "maxY" : 458, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 422, "y" : 452 }, "to" : { "x" : 444, "y" : 452 } }, { "from" : { "x" : 444, "y" : 452 }, "to" : { "x" : 470, "y" : 451 } } ], "endShape" : { "a" : { "x" : 463, "y" : 455 }, "b" : { "x" : 470, "y" : 451 }, "c" : { "x" : 463, "y" : 447 }, "type" : "ARROW", "centre" : { "x" : 463, "y" : 447 } }, "reactionShape" : { "a" : { "x" : 438, "y" : 446 }, "b" : { "x" : 450, "y" : 458 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 444, "y" : 452 } }, "inputs" : [ { "id" : 178596 } ], "outputs" : [ { "id" : 178601 } ] }, { "id" : 178607, "reactomeId" : 10467513, "displayName" : "eNOS:Caveolin-1 complex binds to Nostrin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 63, "y" : 89 }, "minX" : 39, "maxX" : 69, "minY" : 56, "maxY" : 95, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 39, "y" : 95 }, "to" : { "x" : 63, "y" : 89 } }, { "from" : { "x" : 63, "y" : 89 }, "to" : { "x" : 63, "y" : 56 } } ], "endShape" : { "a" : { "x" : 67, "y" : 63 }, "b" : { "x" : 63, "y" : 56 }, "c" : { "x" : 59, "y" : 63 }, "type" : "ARROW", "centre" : { "x" : 59, "y" : 63 } }, "reactionShape" : { "a" : { "x" : 57, "y" : 83 }, "b" : { "x" : 69, "y" : 95 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 63, "y" : 89 } }, "inputs" : [ { "id" : 178608, "points" : [ { "x" : 57, "y" : 114 } ] }, { "id" : 178593, "points" : [ { "x" : 23, "y" : 538 }, { "x" : 2, "y" : 539 }, { "x" : 0, "y" : 103 } ] } ], "outputs" : [ { "id" : 178609 } ], "catalysts" : [ { "id" : 178608, "points" : [ { "x" : 86, "y" : 114 }, { "x" : 109, "y" : 88 } ] } ] }, { "id" : 178605, "reactomeId" : 10467505, "displayName" : "eNOS:NOSIP translocation from caveolae to intracellular compartments", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 308, "y" : 180 }, "minX" : 129, "maxX" : 493, "minY" : 174, "maxY" : 186, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 129, "y" : 180 }, "to" : { "x" : 308, "y" : 180 } }, { "from" : { "x" : 308, "y" : 180 }, "to" : { "x" : 493, "y" : 179 } } ], "endShape" : { "a" : { "x" : 486, "y" : 183 }, "b" : { "x" : 493, "y" : 179 }, "c" : { "x" : 486, "y" : 175 }, "type" : "ARROW", "centre" : { "x" : 486, "y" : 175 } }, "reactionShape" : { "a" : { "x" : 302, "y" : 174 }, "b" : { "x" : 314, "y" : 186 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 308, "y" : 180 } }, "inputs" : [ { "id" : 178604 } ], "outputs" : [ { "id" : 178606 } ], "catalysts" : [ { "id" : 178604, "points" : [ { "x" : 129, "y" : 172 }, { "x" : 307, "y" : 139 } ] } ] }, { "id" : 178610, "reactomeId" : 10467496, "displayName" : "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 233, "y" : 49 }, "minX" : 183, "maxX" : 256, "minY" : 28, "maxY" : 55, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 183, "y" : 28 }, "to" : { "x" : 212, "y" : 49 } }, { "from" : { "x" : 212, "y" : 49 }, "to" : { "x" : 233, "y" : 49 } }, { "from" : { "x" : 233, "y" : 49 }, "to" : { "x" : 256, "y" : 48 } } ], "endShape" : { "a" : { "x" : 249, "y" : 52 }, "b" : { "x" : 256, "y" : 48 }, "c" : { "x" : 249, "y" : 44 }, "type" : "ARROW", "centre" : { "x" : 249, "y" : 44 } }, "reactionShape" : { "a" : { "x" : 227, "y" : 43 }, "b" : { "x" : 239, "y" : 55 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 233, "y" : 49 } }, "inputs" : [ { "id" : 178611, "points" : [ { "x" : 165, "y" : 43 } ] }, { "id" : 178609, "points" : [ { "x" : 123, "y" : 31 } ] } ], "outputs" : [ { "id" : 178612 } ], "catalysts" : [ { "id" : 178609, "points" : [ { "x" : 123, "y" : 23 }, { "x" : 232, "y" : 0 } ] } ] }, { "id" : 178583, "reactomeId" : 10467462, "displayName" : "Palmitoylation of eNOS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 532, "y" : 297 }, "minX" : 491, "maxX" : 538, "minY" : 291, "maxY" : 329, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 491, "y" : 297 }, "to" : { "x" : 532, "y" : 297 } }, { "from" : { "x" : 532, "y" : 297 }, "to" : { "x" : 532, "y" : 329 } } ], "reactionShape" : { "a" : { "x" : 526, "y" : 291 }, "b" : { "x" : 538, "y" : 303 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 532, "y" : 297 } }, "inputs" : [ { "id" : 178584, "points" : [ { "x" : 451, "y" : 241 } ], "stoichiometry" : 2 }, { "id" : 178585, "points" : [ { "x" : 438, "y" : 297 } ] } ], "outputs" : [ { "id" : 178586, "points" : [ { "x" : 532, "y" : 361 } ] }, { "id" : 178587, "points" : [ { "x" : 435, "y" : 335 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 178588, "points" : [ { "x" : 532, "y" : 258 } ] } ] }, { "id" : 178613, "reactomeId" : 10467453, "displayName" : "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 430, "y" : 48 }, "minX" : 411, "maxX" : 459, "minY" : 42, "maxY" : 54, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 411, "y" : 49 }, "to" : { "x" : 430, "y" : 48 } }, { "from" : { "x" : 430, "y" : 48 }, "to" : { "x" : 459, "y" : 48 } } ], "endShape" : { "a" : { "x" : 452, "y" : 52 }, "b" : { "x" : 459, "y" : 48 }, "c" : { "x" : 452, "y" : 44 }, "type" : "ARROW", "centre" : { "x" : 452, "y" : 44 } }, "reactionShape" : { "a" : { "x" : 424, "y" : 42 }, "b" : { "x" : 436, "y" : 54 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 430, "y" : 48 } }, "inputs" : [ { "id" : 178614, "points" : [ { "x" : 397, "y" : 90 } ] }, { "id" : 178612, "points" : [ { "x" : 394, "y" : 48 } ] } ], "outputs" : [ { "id" : 178615 } ], "catalysts" : [ { "id" : 178612, "points" : [ { "x" : 368, "y" : 26 }, { "x" : 431, "y" : 2 } ] } ] }, { "id" : 178618, "reactomeId" : 10513197, "displayName" : "CYGB dioxygenates NO", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1182, "y" : 534 }, "minX" : 1176, "maxX" : 1188, "minY" : 478, "maxY" : 595, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1182, "y" : 595 }, "to" : { "x" : 1182, "y" : 534 } }, { "from" : { "x" : 1182, "y" : 534 }, "to" : { "x" : 1181, "y" : 478 } } ], "reactionShape" : { "a" : { "x" : 1176, "y" : 528 }, "b" : { "x" : 1188, "y" : 540 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1182, "y" : 534 } }, "inputs" : [ { "id" : 178619, "points" : [ { "x" : 1182, "y" : 663 } ] }, { "id" : 178620, "points" : [ { "x" : 1202, "y" : 594 } ] }, { "id" : 178621, "points" : [ { "x" : 1220, "y" : 631 } ] } ], "outputs" : [ { "id" : 178622, "points" : [ { "x" : 1181, "y" : 436 } ] }, { "id" : 178623, "points" : [ { "x" : 1131, "y" : 450 } ] } ], "catalysts" : [ { "id" : 178620, "points" : [ { "x" : 1245, "y" : 574 }, { "x" : 1245, "y" : 534 } ] } ], "activators" : [ { "id" : 178624, "points" : [ { "x" : 1212, "y" : 517 } ] }, { "id" : 178625, "points" : [ { "x" : 1143, "y" : 514 } ] } ] }, { "id" : 178616, "reactomeId" : 10467491, "displayName" : "NOSTRIN mediated translocation of eNOS from plasma membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 731, "y" : 47 }, "minX" : 598, "maxX" : 737, "minY" : 41, "maxY" : 106, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 598, "y" : 49 }, "to" : { "x" : 731, "y" : 47 } }, { "from" : { "x" : 731, "y" : 47 }, "to" : { "x" : 732, "y" : 106 } } ], "endShape" : { "a" : { "x" : 728, "y" : 99 }, "b" : { "x" : 732, "y" : 106 }, "c" : { "x" : 736, "y" : 99 }, "type" : "ARROW", "centre" : { "x" : 736, "y" : 99 } }, "reactionShape" : { "a" : { "x" : 725, "y" : 41 }, "b" : { "x" : 737, "y" : 53 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 731, "y" : 47 } }, "inputs" : [ { "id" : 178615 } ], "outputs" : [ { "id" : 178617 } ] }, { "id" : 178591, "reactomeId" : 10467510, "displayName" : "eNOS associates with Caveolin-1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 83, "y" : 496 }, "minX" : 77, "maxX" : 89, "minY" : 476, "maxY" : 525, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 83, "y" : 476 }, "to" : { "x" : 83, "y" : 496 } }, { "from" : { "x" : 83, "y" : 496 }, "to" : { "x" : 83, "y" : 525 } } ], "endShape" : { "a" : { "x" : 79, "y" : 518 }, "b" : { "x" : 83, "y" : 525 }, "c" : { "x" : 87, "y" : 518 }, "type" : "ARROW", "centre" : { "x" : 87, "y" : 518 } }, "reactionShape" : { "a" : { "x" : 77, "y" : 490 }, "b" : { "x" : 89, "y" : 502 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 83, "y" : 496 } }, "inputs" : [ { "id" : 178590, "points" : [ { "x" : 83, "y" : 395 } ] }, { "id" : 178592, "points" : [ { "x" : 246, "y" : 603 }, { "x" : 232, "y" : 476 } ] } ], "outputs" : [ { "id" : 178593 } ], "catalysts" : [ { "id" : 178592, "points" : [ { "x" : 245, "y" : 603 }, { "x" : 217, "y" : 502 } ] } ] }, { "id" : 178589, "reactomeId" : 10467507, "displayName" : "eNOS translocation from Golgi to Caveolae", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 315, "y" : 361 }, "minX" : 149, "maxX" : 478, "minY" : 355, "maxY" : 376, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 478, "y" : 376 }, "to" : { "x" : 315, "y" : 361 } }, { "from" : { "x" : 315, "y" : 361 }, "to" : { "x" : 149, "y" : 365 } } ], "endShape" : { "a" : { "x" : 156, "y" : 361 }, "b" : { "x" : 149, "y" : 365 }, "c" : { "x" : 156, "y" : 369 }, "type" : "ARROW", "centre" : { "x" : 156, "y" : 369 } }, "reactionShape" : { "a" : { "x" : 309, "y" : 355 }, "b" : { "x" : 321, "y" : 367 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 315, "y" : 361 } }, "inputs" : [ { "id" : 178586, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 178590 } ] } ], "compartments" : [ { "id" : 178642, "reactomeId" : 24337, "displayName" : "endocytic vesicle membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 733, "y" : 207 }, "minX" : 681, "maxX" : 786, "minY" : 138, "maxY" : 276, "prop" : { "x" : 681, "y" : 138, "width" : 105, "height" : 138 }, "textPosition" : { "x" : 684, "y" : 208 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 178617 ] }, { "id" : 178640, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 951, "y" : 405 }, "minX" : 78, "maxX" : 1824, "minY" : 45, "maxY" : 766, "prop" : { "x" : 78, "y" : 45, "width" : 1746, "height" : 721 }, "textPosition" : { "x" : 738, "y" : 363 }, "insets" : { "x" : 88, "y" : 55, "width" : 1726, "height" : 701 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 178585, 178584, 178639, 178589, 178590, 178591, 178593, 178594, 178596, 178599, 178600, 178603, 178604, 178605, 178608, 178610, 178612, 178614, 178615, 178642, 178616, 178651, 178609, 178641, 178619, 178630, 178611, 178620, 178618, 178627, 178626, 178628, 178629, 178657, 178668, 178636, 178632, 178638, 178633, 178637, 178634, 178635, 178622, 178658, 178669, 178670, 178631, 178587, 178597, 178595, 178598, 178623, 178621, 178624, 178625, 178602, 178613 ] }, { "id" : 178641, "reactomeId" : 13977, "displayName" : "lipid droplet", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 296, "y" : 635 }, "minX" : 251, "maxX" : 341, "minY" : 604, "maxY" : 667, "prop" : { "x" : 251, "y" : 604, "width" : 90, "height" : 63 }, "textPosition" : { "x" : 264, "y" : 609 }, "insets" : { "x" : 261, "y" : 614, "width" : 70, "height" : 43 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 178592 ] }, { "id" : 178639, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 580, "y" : 321 }, "minX" : 528, "maxX" : 632, "minY" : 136, "maxY" : 507, "prop" : { "x" : 528, "y" : 136, "width" : 104, "height" : 371 }, "textPosition" : { "x" : 540, "y" : 465 }, "insets" : { "x" : 538, "y" : 146, "width" : 84, "height" : 351 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 178583, 178588, 178586, 178601, 178606 ] } ], "notes" : [ ], "links" : [ { "id" : 178670, "renderableClass" : "Interaction", "position" : { "x" : 1059, "y" : 269 }, "minX" : 987, "maxX" : 1132, "minY" : 240, "maxY" : 299, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1132, "y" : 240 }, "to" : { "x" : 987, "y" : 299 } } ], "endShape" : { "a" : { "x" : 992, "y" : 293 }, "b" : { "x" : 987, "y" : 299 }, "c" : { "x" : 995, "y" : 300 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 995, "y" : 300 } }, "reactionShape" : { "a" : { "x" : 1053, "y" : 263 }, "b" : { "x" : 1065, "y" : 275 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1059, "y" : 269 } }, "inputs" : [ { "id" : 178658 } ], "outputs" : [ { "id" : 178651 } ] }, { "id" : 178669, "renderableClass" : "Interaction", "position" : { "x" : 1269, "y" : 331 }, "minX" : 1212, "maxX" : 1326, "minY" : 240, "maxY" : 422, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1326, "y" : 422 }, "to" : { "x" : 1212, "y" : 240 } } ], "endShape" : { "a" : { "x" : 1219, "y" : 244 }, "b" : { "x" : 1212, "y" : 240 }, "c" : { "x" : 1212, "y" : 248 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1212, "y" : 248 } }, "reactionShape" : { "a" : { "x" : 1263, "y" : 325 }, "b" : { "x" : 1275, "y" : 337 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1269, "y" : 331 } }, "inputs" : [ { "id" : 178636 } ], "outputs" : [ { "id" : 178658 } ] } ], "shadows" : [ { "id" : 178672, "reactomeId" : 10556923, "displayName" : "NOSIP mediated eNOS trafficking", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 297, "y" : 280 }, "minX" : 11, "maxX" : 584, "minY" : 158, "maxY" : 402, "prop" : { "x" : 11, "y" : 158, "width" : 573, "height" : 244 }, "points" : [ { "x" : 11, "y" : 158 }, { "x" : 584, "y" : 158 }, { "x" : 584, "y" : 402 }, { "x" : 11, "y" : 402 } ], "colour" : "#dc3912" }, { "id" : 178673, "reactomeId" : 10556925, "displayName" : "NOSTRIN mediated eNOS trafficking", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 400, "y" : 283 }, "minX" : -4, "maxX" : 804, "minY" : 7, "maxY" : 559, "prop" : { "x" : -4, "y" : 7, "width" : 808, "height" : 552 }, "points" : [ { "x" : -4, "y" : 7 }, { "x" : 804, "y" : 7 }, { "x" : 804, "y" : 559 }, { "x" : -4, "y" : 559 } ], "colour" : "#008000" }, { "id" : 178671, "reactomeId" : 10556897, "displayName" : "eNOS activation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 865, "y" : 452 }, "minX" : 11, "maxX" : 1719, "minY" : 198, "maxY" : 706, "prop" : { "x" : 804, "y" : 198, "width" : 915, "height" : 361 }, "points" : [ { "x" : 11, "y" : 198 }, { "x" : 1719, "y" : 198 }, { "x" : 1719, "y" : 706 }, { "x" : 11, "y" : 706 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 1824, "minY" : 0, "maxY" : 766, "disease" : false }