{ "dbId" : 10556283, "stableId" : "R-SSC-68877", "displayName" : "Mitotic Prometaphase", "nodes" : [ { "id" : 143490, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1048, "y" : 744 }, "minX" : 1029, "maxX" : 1069, "minY" : 707, "maxY" : 755, "prop" : { "x" : 1029, "y" : 734, "width" : 39, "height" : 21 }, "textPosition" : { "x" : 1031, "y" : 734 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1063, "y" : 739 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1063, "y" : 739 } } }, "connectors" : [ { "edgeId" : 143489, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1052, "y" : 731 }, "to" : { "x" : 1064, "y" : 707 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 143491, "reactomeId" : 10456705, "displayName" : "PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1240, "y" : 729 }, "minX" : 1148, "maxX" : 1265, "minY" : 712, "maxY" : 741, "prop" : { "x" : 1222, "y" : 718, "width" : 37, "height" : 23 }, "textPosition" : { "x" : 1222, "y" : 719 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1259, "y" : 718 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1259, "y" : 718 } } }, "connectors" : [ { "edgeId" : 143489, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1219, "y" : 730 }, "to" : { "x" : 1148, "y" : 735 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1212, "y" : 734 }, "b" : { "x" : 1219, "y" : 730 }, "c" : { "x" : 1212, "y" : 726 }, "type" : "ARROW", "centre" : { "x" : 1212, "y" : 726 } } } ] }, { "id" : 143488, "reactomeId" : 10552323, "displayName" : "FIRRM:PPP1CC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1275, "y" : 689 }, "minX" : 1117, "maxX" : 1328, "minY" : 672, "maxY" : 729, "prop" : { "x" : 1228, "y" : 678, "width" : 94, "height" : 23 }, "textPosition" : { "x" : 1247, "y" : 666 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1322, "y" : 678 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1322, "y" : 678 } } }, "connectors" : [ { "edgeId" : 143489, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1225, "y" : 699 }, "to" : { "x" : 1118, "y" : 725 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1117, "y" : 721 }, "b" : { "x" : 1119, "y" : 729 }, "c" : { "x" : 1118, "y" : 725 }, "type" : "STOP", "centre" : { "x" : 1118, "y" : 725 } } }, { "edgeId" : 143486, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143494, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1603, "y" : 656 }, "minX" : 1556, "maxX" : 1624, "minY" : 644, "maxY" : 667, "prop" : { "x" : 1583, "y" : 645, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 1587, "y" : 645 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1618, "y" : 650 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1618, "y" : 650 } } }, "connectors" : [ { "edgeId" : 143493, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1580, "y" : 656 }, "to" : { "x" : 1556, "y" : 657 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143495, "reactomeId" : 10552318, "displayName" : "phospho-FIRRM", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1424, "y" : 747 }, "minX" : 1362, "maxX" : 1548, "minY" : 726, "maxY" : 763, "prop" : { "x" : 1362, "y" : 732, "width" : 124, "height" : 31 }, "textPosition" : { "x" : 1372, "y" : 737 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1486, "y" : 732 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1486, "y" : 732 } } }, "connectors" : [ { "edgeId" : 143493, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1489, "y" : 747 }, "to" : { "x" : 1548, "y" : 747 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1496, "y" : 743 }, "b" : { "x" : 1489, "y" : 747 }, "c" : { "x" : 1496, "y" : 751 }, "type" : "ARROW", "centre" : { "x" : 1496, "y" : 751 } } } ] }, { "id" : 143492, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1251, "y" : 760 }, "minX" : 1148, "maxX" : 1268, "minY" : 735, "maxY" : 772, "prop" : { "x" : 1235, "y" : 749, "width" : 32, "height" : 23 }, "textPosition" : { "x" : 1241, "y" : 750 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1262, "y" : 754 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1262, "y" : 754 } } }, "connectors" : [ { "edgeId" : 143489, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1232, "y" : 756 }, "to" : { "x" : 1148, "y" : 735 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1224, "y" : 758 }, "b" : { "x" : 1232, "y" : 756 }, "c" : { "x" : 1226, "y" : 750 }, "type" : "ARROW", "centre" : { "x" : 1226, "y" : 750 } } } ] }, { "id" : 143498, "reactomeId" : 10555543, "displayName" : "S Phase", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 490, "y" : 105 }, "minX" : 442, "maxX" : 538, "minY" : 82, "maxY" : 129, "prop" : { "x" : 442, "y" : 82, "width" : 96, "height" : 47 }, "textPosition" : { "x" : 456, "y" : 91 }, "connectors" : [ ] }, { "id" : 143496, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1641, "y" : 712 }, "minX" : 1548, "maxX" : 1665, "minY" : 699, "maxY" : 747, "prop" : { "x" : 1619, "y" : 700, "width" : 45, "height" : 24 }, "textPosition" : { "x" : 1625, "y" : 701 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1659, "y" : 705 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1659, "y" : 705 } } }, "connectors" : [ { "edgeId" : 143493, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1616, "y" : 720 }, "to" : { "x" : 1548, "y" : 747 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1611, "y" : 726 }, "b" : { "x" : 1616, "y" : 720 }, "c" : { "x" : 1608, "y" : 719 }, "type" : "ARROW", "centre" : { "x" : 1608, "y" : 719 } } } ] }, { "id" : 143502, "reactomeId" : 10557133, "displayName" : "Mitotic Prophase", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 123, "y" : 69 }, "minX" : 51, "maxX" : 196, "minY" : 51, "maxY" : 87, "prop" : { "x" : 51, "y" : 51, "width" : 145, "height" : 36 }, "textPosition" : { "x" : 63, "y" : 54 }, "connectors" : [ ] }, { "id" : 143501, "reactomeId" : 10556365, "displayName" : "Mitotic Metaphase and Anaphase", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1085, "y" : 802 }, "minX" : 952, "maxX" : 1219, "minY" : 781, "maxY" : 824, "prop" : { "x" : 952, "y" : 781, "width" : 267, "height" : 43 }, "textPosition" : { "x" : 972, "y" : 788 }, "connectors" : [ ] }, { "id" : 143406, "reactomeId" : 10494759, "displayName" : "Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 718, "y" : 476 }, "minX" : 624, "maxX" : 818, "minY" : 408, "maxY" : 528, "prop" : { "x" : 624, "y" : 450, "width" : 188, "height" : 52 }, "textPosition" : { "x" : 629, "y" : 453 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 812, "y" : 450 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 812, "y" : 450 } } }, "connectors" : [ { "edgeId" : 143429, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 716, "y" : 447 }, "to" : { "x" : 715, "y" : 408 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 712, "y" : 440 }, "b" : { "x" : 716, "y" : 447 }, "c" : { "x" : 720, "y" : 440 }, "type" : "ARROW", "centre" : { "x" : 720, "y" : 440 } } }, { "edgeId" : 143405, "type" : "INPUT", "segments" : [ { "from" : { "x" : 717, "y" : 505 }, "to" : { "x" : 717, "y" : 528 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143407, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 661, "y" : 527 }, "minX" : 641, "maxX" : 717, "minY" : 513, "maxY" : 541, "prop" : { "x" : 641, "y" : 514, "width" : 40, "height" : 27 }, "textPosition" : { "x" : 645, "y" : 517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 676, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 676, "y" : 519 } } }, "connectors" : [ { "edgeId" : 143405, "type" : "INPUT", "segments" : [ { "from" : { "x" : 684, "y" : 527 }, "to" : { "x" : 717, "y" : 528 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 694, "y" : 521 }, "b" : { "x" : 706, "y" : 533 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 700, "y" : 527 } } } } ] }, { "id" : 143410, "reactomeId" : 10457003, "displayName" : "phospho-p-T210-PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 585, "y" : 563 }, "minX" : 501, "maxX" : 708, "minY" : 546, "maxY" : 574, "prop" : { "x" : 537, "y" : 552, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 546, "y" : 546 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 634, "y" : 552 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 634, "y" : 552 } } }, "connectors" : [ { "edgeId" : 143405, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 637, "y" : 562 }, "to" : { "x" : 700, "y" : 561 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 704, "y" : 561 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 704, "y" : 561 } } }, { "edgeId" : 143415, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 534, "y" : 561 }, "to" : { "x" : 509, "y" : 560 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 505, "y" : 560 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 505, "y" : 560 } } } ] }, { "id" : 143408, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 655, "y" : 592 }, "minX" : 635, "maxX" : 717, "minY" : 578, "maxY" : 605, "prop" : { "x" : 635, "y" : 579, "width" : 41, "height" : 26 }, "textPosition" : { "x" : 639, "y" : 581 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 671, "y" : 584 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 671, "y" : 584 } } }, "connectors" : [ { "edgeId" : 143405, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 679, "y" : 590 }, "to" : { "x" : 717, "y" : 588 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 692, "y" : 583 }, "b" : { "x" : 704, "y" : 595 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 698, "y" : 589 } } }, "endShape" : { "a" : { "x" : 686, "y" : 586 }, "b" : { "x" : 679, "y" : 590 }, "c" : { "x" : 686, "y" : 594 }, "type" : "ARROW", "centre" : { "x" : 686, "y" : 594 } } } ] }, { "id" : 143409, "reactomeId" : 10494769, "displayName" : "p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 717, "y" : 660 }, "minX" : 624, "maxX" : 817, "minY" : 588, "maxY" : 728, "prop" : { "x" : 624, "y" : 629, "width" : 187, "height" : 62 }, "textPosition" : { "x" : 624, "y" : 628 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 811, "y" : 629 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 811, "y" : 629 } } }, "connectors" : [ { "edgeId" : 143405, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 717, "y" : 626 }, "to" : { "x" : 717, "y" : 588 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 713, "y" : 619 }, "b" : { "x" : 717, "y" : 626 }, "c" : { "x" : 721, "y" : 619 }, "type" : "ARROW", "centre" : { "x" : 721, "y" : 619 } } }, { "edgeId" : 143411, "type" : "INPUT", "segments" : [ { "from" : { "x" : 717, "y" : 694 }, "to" : { "x" : 717, "y" : 709 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143411, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 698, "y" : 694 }, "to" : { "x" : 685, "y" : 715 } }, { "from" : { "x" : 685, "y" : 715 }, "to" : { "x" : 703, "y" : 722 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 707, "y" : 724 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 707, "y" : 724 } } } ] }, { "id" : 143414, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 792, "y" : 748 }, "minX" : 718, "maxX" : 809, "minY" : 736, "maxY" : 760, "prop" : { "x" : 776, "y" : 737, "width" : 32, "height" : 23 }, "textPosition" : { "x" : 782, "y" : 738 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 803, "y" : 742 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 803, "y" : 742 } } }, "connectors" : [ { "edgeId" : 143411, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 773, "y" : 747 }, "to" : { "x" : 718, "y" : 747 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 766, "y" : 751 }, "b" : { "x" : 773, "y" : 747 }, "c" : { "x" : 766, "y" : 743 }, "type" : "ARROW", "centre" : { "x" : 766, "y" : 743 } } } ] }, { "id" : 143412, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 791, "y" : 707 }, "minX" : 717, "maxX" : 812, "minY" : 695, "maxY" : 719, "prop" : { "x" : 771, "y" : 696, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 774, "y" : 697 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 806, "y" : 701 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 806, "y" : 701 } } }, "connectors" : [ { "edgeId" : 143411, "type" : "INPUT", "segments" : [ { "from" : { "x" : 768, "y" : 707 }, "to" : { "x" : 717, "y" : 709 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 143413, "reactomeId" : 10494775, "displayName" : "p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 713, "y" : 801 }, "minX" : 625, "maxX" : 808, "minY" : 747, "maxY" : 832, "prop" : { "x" : 625, "y" : 771, "width" : 177, "height" : 61 }, "textPosition" : { "x" : 626, "y" : 769 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 802, "y" : 771 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 802, "y" : 771 } } }, "connectors" : [ { "edgeId" : 143411, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 715, "y" : 768 }, "to" : { "x" : 718, "y" : 747 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 712, "y" : 761 }, "b" : { "x" : 715, "y" : 768 }, "c" : { "x" : 720, "y" : 762 }, "type" : "ARROW", "centre" : { "x" : 720, "y" : 762 } } } ] }, { "id" : 143418, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 428, "y" : 597 }, "minX" : 408, "maxX" : 494, "minY" : 582, "maxY" : 612, "prop" : { "x" : 408, "y" : 583, "width" : 40, "height" : 29 }, "textPosition" : { "x" : 411, "y" : 587 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 443, "y" : 588 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 443, "y" : 588 } } }, "connectors" : [ { "edgeId" : 143415, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 451, "y" : 595 }, "to" : { "x" : 494, "y" : 592 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 466, "y" : 587 }, "b" : { "x" : 478, "y" : 599 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 472, "y" : 593 } } }, "endShape" : { "a" : { "x" : 458, "y" : 591 }, "b" : { "x" : 451, "y" : 595 }, "c" : { "x" : 458, "y" : 599 }, "type" : "ARROW", "centre" : { "x" : 458, "y" : 599 } } } ] }, { "id" : 143419, "reactomeId" : 10504197, "displayName" : "Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 495, "y" : 666 }, "minX" : 403, "maxX" : 593, "minY" : 592, "maxY" : 692, "prop" : { "x" : 403, "y" : 641, "width" : 184, "height" : 51 }, "textPosition" : { "x" : 403, "y" : 643 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 587, "y" : 641 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 587, "y" : 641 } } }, "connectors" : [ { "edgeId" : 143415, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 494, "y" : 638 }, "to" : { "x" : 494, "y" : 592 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 490, "y" : 631 }, "b" : { "x" : 494, "y" : 638 }, "c" : { "x" : 498, "y" : 631 }, "type" : "ARROW", "centre" : { "x" : 498, "y" : 631 } } }, { "edgeId" : 143420, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143416, "reactomeId" : 10504187, "displayName" : "Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 495, "y" : 478 }, "minX" : 420, "maxX" : 576, "minY" : 411, "maxY" : 533, "prop" : { "x" : 420, "y" : 454, "width" : 150, "height" : 49 }, "textPosition" : { "x" : 423, "y" : 454 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 570, "y" : 454 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 570, "y" : 454 } } }, "connectors" : [ { "edgeId" : 143424, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 493, "y" : 451 }, "to" : { "x" : 492, "y" : 411 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 489, "y" : 444 }, "b" : { "x" : 493, "y" : 451 }, "c" : { "x" : 497, "y" : 444 }, "type" : "ARROW", "centre" : { "x" : 497, "y" : 444 } } }, { "edgeId" : 143415, "type" : "INPUT", "segments" : [ { "from" : { "x" : 494, "y" : 506 }, "to" : { "x" : 493, "y" : 533 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143417, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 438, "y" : 528 }, "minX" : 419, "maxX" : 493, "minY" : 513, "maxY" : 542, "prop" : { "x" : 419, "y" : 514, "width" : 39, "height" : 28 }, "textPosition" : { "x" : 423, "y" : 517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 453, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 453, "y" : 519 } } }, "connectors" : [ { "edgeId" : 143415, "type" : "INPUT", "segments" : [ { "from" : { "x" : 461, "y" : 529 }, "to" : { "x" : 493, "y" : 533 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 471, "y" : 525 }, "b" : { "x" : 483, "y" : 537 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 477, "y" : 531 } } } } ] }, { "id" : 143422, "reactomeId" : 10504258, "displayName" : "phospho-CDCA5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 325, "y" : 788 }, "minX" : 243, "maxX" : 497, "minY" : 739, "maxY" : 803, "prop" : { "x" : 243, "y" : 773, "width" : 165, "height" : 30 }, "textPosition" : { "x" : 271, "y" : 777 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 408, "y" : 773 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 408, "y" : 773 } } }, "connectors" : [ { "edgeId" : 143420, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 377, "y" : 770 }, "to" : { "x" : 497, "y" : 739 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 383, "y" : 764 }, "b" : { "x" : 377, "y" : 770 }, "c" : { "x" : 385, "y" : 772 }, "type" : "ARROW", "centre" : { "x" : 385, "y" : 772 } } } ] }, { "id" : 143423, "reactomeId" : 1638790, "displayName" : "Sister Chromatid", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 497, "y" : 820 }, "minX" : 439, "maxX" : 555, "minY" : 739, "maxY" : 833, "prop" : { "x" : 439, "y" : 807, "width" : 116, "height" : 26 }, "textPosition" : { "x" : 441, "y" : 809 }, "connectors" : [ { "edgeId" : 143420, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 497, "y" : 804 }, "to" : { "x" : 497, "y" : 739 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 491, "y" : 765 }, "b" : { "x" : 503, "y" : 777 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 497, "y" : 771 } } }, "endShape" : { "a" : { "x" : 493, "y" : 797 }, "b" : { "x" : 497, "y" : 804 }, "c" : { "x" : 501, "y" : 797 }, "type" : "ARROW", "centre" : { "x" : 501, "y" : 797 } } } ] }, { "id" : 143421, "reactomeId" : 10504256, "displayName" : "p-Ac-Cohesin:PDS5:WAPAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 367, "y" : 730 }, "minX" : 287, "maxX" : 497, "minY" : 707, "maxY" : 748, "prop" : { "x" : 317, "y" : 713, "width" : 100, "height" : 35 }, "textPosition" : { "x" : 320, "y" : 713 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 417, "y" : 713 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 417, "y" : 713 } } }, "connectors" : [ { "edgeId" : 143446, "type" : "INPUT", "segments" : [ { "from" : { "x" : 314, "y" : 728 }, "to" : { "x" : 287, "y" : 728 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143420, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 420, "y" : 733 }, "to" : { "x" : 497, "y" : 739 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 427, "y" : 730 }, "b" : { "x" : 420, "y" : 733 }, "c" : { "x" : 427, "y" : 738 }, "type" : "ARROW", "centre" : { "x" : 427, "y" : 738 } } } ] }, { "id" : 143426, "reactomeId" : 10504348, "displayName" : "Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 491, "y" : 304 }, "minX" : 434, "maxX" : 555, "minY" : 260, "maxY" : 366, "prop" : { "x" : 434, "y" : 266, "width" : 115, "height" : 77 }, "textPosition" : { "x" : 442, "y" : 266 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 549, "y" : 266 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 549, "y" : 266 } } }, "connectors" : [ { "edgeId" : 143424, "type" : "INPUT", "segments" : [ { "from" : { "x" : 491, "y" : 346 }, "to" : { "x" : 492, "y" : 366 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143427, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 419, "y" : 419 }, "minX" : 397, "maxX" : 492, "minY" : 405, "maxY" : 432, "prop" : { "x" : 397, "y" : 406, "width" : 44, "height" : 26 }, "textPosition" : { "x" : 402, "y" : 408 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 436, "y" : 411 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 436, "y" : 411 } } }, "connectors" : [ { "edgeId" : 143424, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 444, "y" : 416 }, "to" : { "x" : 492, "y" : 411 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 462, "y" : 407 }, "b" : { "x" : 474, "y" : 419 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 468, "y" : 413 } } }, "endShape" : { "a" : { "x" : 450, "y" : 411 }, "b" : { "x" : 444, "y" : 416 }, "c" : { "x" : 451, "y" : 419 }, "type" : "ARROW", "centre" : { "x" : 451, "y" : 419 } } } ] }, { "id" : 143425, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 420, "y" : 368 }, "minX" : 399, "maxX" : 492, "minY" : 354, "maxY" : 382, "prop" : { "x" : 399, "y" : 355, "width" : 42, "height" : 27 }, "textPosition" : { "x" : 404, "y" : 358 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 436, "y" : 360 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 436, "y" : 360 } } }, "connectors" : [ { "edgeId" : 143424, "type" : "INPUT", "segments" : [ { "from" : { "x" : 444, "y" : 367 }, "to" : { "x" : 492, "y" : 366 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 462, "y" : 360 }, "b" : { "x" : 474, "y" : 372 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 468, "y" : 366 } } } } ] }, { "id" : 143430, "reactomeId" : 10504360, "displayName" : "Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 720, "y" : 262 }, "minX" : 655, "maxX" : 791, "minY" : 210, "maxY" : 353, "prop" : { "x" : 655, "y" : 216, "width" : 130, "height" : 92 }, "textPosition" : { "x" : 661, "y" : 217 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 785, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 785, "y" : 216 } } }, "connectors" : [ { "edgeId" : 143429, "type" : "INPUT", "segments" : [ { "from" : { "x" : 717, "y" : 311 }, "to" : { "x" : 716, "y" : 353 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143433, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143431, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 783, "y" : 356 }, "minX" : 716, "maxX" : 804, "minY" : 340, "maxY" : 371, "prop" : { "x" : 763, "y" : 341, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 767, "y" : 345 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 798, "y" : 346 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 798, "y" : 346 } } }, "connectors" : [ { "edgeId" : 143429, "type" : "INPUT", "segments" : [ { "from" : { "x" : 760, "y" : 355 }, "to" : { "x" : 716, "y" : 353 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 732, "y" : 348 }, "b" : { "x" : 744, "y" : 360 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 738, "y" : 354 } } } } ] }, { "id" : 143428, "reactomeId" : 10459860, "displayName" : "CCNB1,CCNB2:p-T161-CDK1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 604, "y" : 386 }, "minX" : 500, "maxX" : 707, "minY" : 367, "maxY" : 405, "prop" : { "x" : 555, "y" : 367, "width" : 99, "height" : 38 }, "textPosition" : { "x" : 555, "y" : 368 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 143424, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 549, "y" : 386 }, "to" : { "x" : 508, "y" : 387 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 504, "y" : 387 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 504, "y" : 387 } } }, { "edgeId" : 143429, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 660, "y" : 386 }, "to" : { "x" : 699, "y" : 386 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 703, "y" : 386 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 703, "y" : 386 } } } ] }, { "id" : 143434, "reactomeId" : 10504456, "displayName" : "Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 717, "y" : 100 }, "minX" : 621, "maxX" : 819, "minY" : 75, "maxY" : 155, "prop" : { "x" : 621, "y" : 81, "width" : 192, "height" : 38 }, "textPosition" : { "x" : 624, "y" : 84 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 813, "y" : 81 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 813, "y" : 81 } } }, "connectors" : [ { "edgeId" : 143433, "type" : "INPUT", "segments" : [ { "from" : { "x" : 717, "y" : 122 }, "to" : { "x" : 719, "y" : 155 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143435, "reactomeId" : 10471549, "displayName" : "Microtubule-bound kinetochore", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 968, "y" : 192 }, "minX" : 719, "maxX" : 1306, "minY" : 155, "maxY" : 321, "prop" : { "x" : 903, "y" : 174, "width" : 130, "height" : 36 }, "textPosition" : { "x" : 903, "y" : 175 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1033, "y" : 174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1033, "y" : 174 } } }, "connectors" : [ { "edgeId" : 143458, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143433, "type" : "INPUT", "segments" : [ { "from" : { "x" : 900, "y" : 182 }, "to" : { "x" : 719, "y" : 155 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 803, "y" : 162 }, "b" : { "x" : 815, "y" : 174 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 809, "y" : 168 } } } }, { "edgeId" : 143476, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1015, "y" : 213 }, "to" : { "x" : 1306, "y" : 321 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143432, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 779, "y" : 409 }, "minX" : 715, "maxX" : 799, "minY" : 396, "maxY" : 422, "prop" : { "x" : 761, "y" : 397, "width" : 37, "height" : 25 }, "textPosition" : { "x" : 763, "y" : 399 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 793, "y" : 402 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 793, "y" : 402 } } }, "connectors" : [ { "edgeId" : 143429, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 758, "y" : 408 }, "to" : { "x" : 715, "y" : 408 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 730, "y" : 402 }, "b" : { "x" : 742, "y" : 414 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 736, "y" : 408 } } }, "endShape" : { "a" : { "x" : 751, "y" : 412 }, "b" : { "x" : 758, "y" : 408 }, "c" : { "x" : 751, "y" : 404 }, "type" : "ARROW", "centre" : { "x" : 751, "y" : 404 } } } ] }, { "id" : 143438, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 897, "y" : 350 }, "minX" : 878, "maxX" : 954, "minY" : 337, "maxY" : 363, "prop" : { "x" : 878, "y" : 338, "width" : 38, "height" : 25 }, "textPosition" : { "x" : 880, "y" : 340 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 911, "y" : 343 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 911, "y" : 343 } } }, "connectors" : [ { "edgeId" : 143436, "type" : "INPUT", "segments" : [ { "from" : { "x" : 919, "y" : 350 }, "to" : { "x" : 954, "y" : 351 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 930, "y" : 344 }, "b" : { "x" : 942, "y" : 356 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 936, "y" : 350 } } } } ], "trivial" : true }, { "id" : 143439, "reactomeId" : 10504621, "displayName" : "Condensin I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 956, "y" : 428 }, "minX" : 915, "maxX" : 1118, "minY" : 389, "maxY" : 439, "prop" : { "x" : 915, "y" : 417, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 915, "y" : 418 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 997, "y" : 417 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 997, "y" : 417 } } }, "connectors" : [ { "edgeId" : 143436, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 955, "y" : 414 }, "to" : { "x" : 954, "y" : 389 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 951, "y" : 407 }, "b" : { "x" : 955, "y" : 414 }, "c" : { "x" : 959, "y" : 407 }, "type" : "ARROW", "centre" : { "x" : 959, "y" : 407 } } }, { "edgeId" : 143442, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1000, "y" : 427 }, "to" : { "x" : 1118, "y" : 426 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143437, "reactomeId" : 10504611, "displayName" : "CK2 Phosphorylated Condensin I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 956, "y" : 309 }, "minX" : 905, "maxX" : 1116, "minY" : 279, "maxY" : 351, "prop" : { "x" : 905, "y" : 285, "width" : 102, "height" : 49 }, "textPosition" : { "x" : 907, "y" : 285 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1007, "y" : 285 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1007, "y" : 285 } } }, "connectors" : [ { "edgeId" : 143436, "type" : "INPUT", "segments" : [ { "from" : { "x" : 954, "y" : 337 }, "to" : { "x" : 954, "y" : 351 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143442, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1010, "y" : 308 }, "to" : { "x" : 1116, "y" : 308 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1017, "y" : 304 }, "b" : { "x" : 1010, "y" : 308 }, "c" : { "x" : 1017, "y" : 312 }, "type" : "ARROW", "centre" : { "x" : 1017, "y" : 312 } } } ] }, { "id" : 143443, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1177, "y" : 427 }, "minX" : 1118, "maxX" : 1198, "minY" : 414, "maxY" : 439, "prop" : { "x" : 1158, "y" : 415, "width" : 39, "height" : 24 }, "textPosition" : { "x" : 1162, "y" : 416 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1192, "y" : 420 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1192, "y" : 420 } } }, "connectors" : [ { "edgeId" : 143442, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1155, "y" : 426 }, "to" : { "x" : 1118, "y" : 426 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1130, "y" : 420 }, "b" : { "x" : 1142, "y" : 432 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1136, "y" : 426 } } } } ] }, { "id" : 143440, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 897, "y" : 390 }, "minX" : 881, "maxX" : 954, "minY" : 378, "maxY" : 402, "prop" : { "x" : 881, "y" : 379, "width" : 32, "height" : 23 }, "textPosition" : { "x" : 887, "y" : 380 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 908, "y" : 384 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 908, "y" : 384 } } }, "connectors" : [ { "edgeId" : 143436, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 916, "y" : 389 }, "to" : { "x" : 954, "y" : 389 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 929, "y" : 383 }, "b" : { "x" : 941, "y" : 395 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 935, "y" : 389 } } }, "endShape" : { "a" : { "x" : 923, "y" : 385 }, "b" : { "x" : 916, "y" : 389 }, "c" : { "x" : 923, "y" : 393 }, "type" : "ARROW", "centre" : { "x" : 923, "y" : 393 } } } ] }, { "id" : 143441, "reactomeId" : 2529006, "displayName" : "Unknown Phosphatase", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 1052, "y" : 372 }, "minX" : 962, "maxX" : 1098, "minY" : 354, "maxY" : 390, "prop" : { "x" : 1006, "y" : 354, "width" : 92, "height" : 36 }, "textPosition" : { "x" : 1006, "y" : 354 }, "connectors" : [ { "edgeId" : 143436, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1003, "y" : 372 }, "to" : { "x" : 970, "y" : 373 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 966, "y" : 373 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 966, "y" : 373 } } } ] }, { "id" : 143447, "reactomeId" : 76194, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 308, "y" : 688 }, "minX" : 277, "maxX" : 340, "minY" : 672, "maxY" : 728, "prop" : { "x" : 277, "y" : 673, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 281, "y" : 677 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 334, "y" : 678 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 334, "y" : 678 } } }, "connectors" : [ { "edgeId" : 143446, "type" : "INPUT", "segments" : [ { "from" : { "x" : 300, "y" : 706 }, "to" : { "x" : 287, "y" : 728 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 287, "y" : 711 }, "b" : { "x" : 299, "y" : 723 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 293, "y" : 717 } } } } ] }, { "id" : 143444, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1182, "y" : 310 }, "minX" : 1116, "maxX" : 1204, "minY" : 298, "maxY" : 321, "prop" : { "x" : 1162, "y" : 299, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 1166, "y" : 299 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1198, "y" : 304 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1198, "y" : 304 } } }, "connectors" : [ { "edgeId" : 143442, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1159, "y" : 309 }, "to" : { "x" : 1116, "y" : 308 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1131, "y" : 302 }, "b" : { "x" : 1143, "y" : 314 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1137, "y" : 308 } } }, "endShape" : { "a" : { "x" : 1152, "y" : 313 }, "b" : { "x" : 1159, "y" : 309 }, "c" : { "x" : 1152, "y" : 305 }, "type" : "ARROW", "centre" : { "x" : 1152, "y" : 305 } } } ] }, { "id" : 143445, "reactomeId" : 10466631, "displayName" : "Casein kinase II", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1181, "y" : 365 }, "minX" : 1125, "maxX" : 1218, "minY" : 341, "maxY" : 383, "prop" : { "x" : 1151, "y" : 347, "width" : 61, "height" : 36 }, "textPosition" : { "x" : 1152, "y" : 348 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1212, "y" : 347 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1212, "y" : 347 } } }, "connectors" : [ { "edgeId" : 143442, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1148, "y" : 365 }, "to" : { "x" : 1133, "y" : 366 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1129, "y" : 366 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1129, "y" : 366 } } } ] }, { "id" : 143450, "reactomeId" : 10504765, "displayName" : "HDAC8", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 263, "y" : 647 }, "minX" : 238, "maxX" : 289, "minY" : 636, "maxY" : 721, "prop" : { "x" : 238, "y" : 636, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 238, "y" : 636 }, "connectors" : [ { "edgeId" : 143446, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 262, "y" : 664 }, "to" : { "x" : 262, "y" : 713 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 262, "y" : 717 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 262, "y" : 717 } } } ] }, { "id" : 143448, "reactomeId" : 10504772, "displayName" : "p-Cohesin:PDS5:WAPAL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 146, "y" : 728 }, "minX" : 100, "maxX" : 243, "minY" : 704, "maxY" : 746, "prop" : { "x" : 100, "y" : 710, "width" : 92, "height" : 36 }, "textPosition" : { "x" : 103, "y" : 711 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 192, "y" : 710 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 192, "y" : 710 } } }, "connectors" : [ { "edgeId" : 143446, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 195, "y" : 728 }, "to" : { "x" : 243, "y" : 728 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 202, "y" : 724 }, "b" : { "x" : 195, "y" : 728 }, "c" : { "x" : 202, "y" : 732 }, "type" : "ARROW", "centre" : { "x" : 202, "y" : 732 } } } ] }, { "id" : 143449, "reactomeId" : 76183, "displayName" : "Ac-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 207, "y" : 683 }, "minX" : 177, "maxX" : 243, "minY" : 667, "maxY" : 728, "prop" : { "x" : 177, "y" : 668, "width" : 61, "height" : 30 }, "textPosition" : { "x" : 182, "y" : 672 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 233, "y" : 673 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 233, "y" : 673 } } }, "connectors" : [ { "edgeId" : 143446, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 219, "y" : 701 }, "to" : { "x" : 243, "y" : 728 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 225, "y" : 708 }, "b" : { "x" : 237, "y" : 720 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 231, "y" : 714 } } }, "endShape" : { "a" : { "x" : 227, "y" : 704 }, "b" : { "x" : 219, "y" : 701 }, "c" : { "x" : 221, "y" : 709 }, "type" : "ARROW", "centre" : { "x" : 221, "y" : 709 } } } ] }, { "id" : 143454, "reactomeId" : 10473351, "displayName" : "Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 200, "y" : 282 }, "minX" : 96, "maxX" : 310, "minY" : 253, "maxY" : 333, "prop" : { "x" : 96, "y" : 259, "width" : 208, "height" : 47 }, "textPosition" : { "x" : 96, "y" : 257 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 304, "y" : 259 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 304, "y" : 259 } } }, "connectors" : [ { "edgeId" : 143451, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143455, "type" : "INPUT", "segments" : [ { "from" : { "x" : 224, "y" : 309 }, "to" : { "x" : 254, "y" : 333 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143452, "reactomeId" : 10473349, "displayName" : "p-T2055-NUMA1 homodimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 122, "y" : 161 }, "minX" : 82, "maxX" : 197, "minY" : 130, "maxY" : 202, "prop" : { "x" : 82, "y" : 136, "width" : 80, "height" : 51 }, "textPosition" : { "x" : 83, "y" : 138 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 162, "y" : 136 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 162, "y" : 136 } } }, "connectors" : [ { "edgeId" : 143451, "type" : "INPUT", "segments" : [ { "from" : { "x" : 165, "y" : 182 }, "to" : { "x" : 197, "y" : 202 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143453, "reactomeId" : 10473322, "displayName" : "Mature centrosomes enriched in gamma-TURC complexes", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 266, "y" : 147 }, "minX" : 197, "maxX" : 337, "minY" : 116, "maxY" : 202, "prop" : { "x" : 201, "y" : 122, "width" : 130, "height" : 50 }, "textPosition" : { "x" : 219, "y" : 95 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 331, "y" : 122 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 331, "y" : 122 } } }, "connectors" : [ { "edgeId" : 143451, "type" : "INPUT", "segments" : [ { "from" : { "x" : 234, "y" : 175 }, "to" : { "x" : 197, "y" : 202 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143459, "reactomeId" : 10456931, "displayName" : "Kinetochore", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 885, "y" : 104 }, "minX" : 843, "maxX" : 969, "minY" : 87, "maxY" : 115, "prop" : { "x" : 843, "y" : 93, "width" : 84, "height" : 22 }, "textPosition" : { "x" : 843, "y" : 94 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 927, "y" : 93 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 927, "y" : 93 } } }, "connectors" : [ { "edgeId" : 143458, "type" : "INPUT", "segments" : [ { "from" : { "x" : 930, "y" : 105 }, "to" : { "x" : 969, "y" : 107 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143456, "reactomeId" : 10463260, "displayName" : "Microtubule", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1103, "y" : 62 }, "minX" : 254, "maxX" : 1254, "minY" : 46, "maxY" : 333, "prop" : { "x" : 1059, "y" : 52, "width" : 89, "height" : 21 }, "textPosition" : { "x" : 1063, "y" : 52 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1148, "y" : 52 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1148, "y" : 52 } } }, "connectors" : [ { "edgeId" : 143458, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1071, "y" : 76 }, "to" : { "x" : 969, "y" : 107 } } ], "stoichiometry" : { "value" : 15, "shape" : { "a" : { "x" : 1014, "y" : 85 }, "b" : { "x" : 1026, "y" : 97 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1020, "y" : 91 } } } }, { "edgeId" : 143463, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1115, "y" : 76 }, "to" : { "x" : 1254, "y" : 190 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143455, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1056, "y" : 62 }, "to" : { "x" : 397, "y" : 62 } }, { "from" : { "x" : 397, "y" : 62 }, "to" : { "x" : 341, "y" : 303 } }, { "from" : { "x" : 341, "y" : 303 }, "to" : { "x" : 254, "y" : 333 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143457, "reactomeId" : 10473355, "displayName" : "p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 208, "y" : 426 }, "minX" : 115, "maxX" : 308, "minY" : 395, "maxY" : 452, "prop" : { "x" : 115, "y" : 401, "width" : 187, "height" : 51 }, "textPosition" : { "x" : 116, "y" : 403 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 302, "y" : 401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 302, "y" : 401 } } }, "connectors" : [ { "edgeId" : 143455, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143462, "reactomeId" : 10546325, "displayName" : "EML4 homotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1358, "y" : 215 }, "minX" : 1254, "maxX" : 1465, "minY" : 190, "maxY" : 321, "prop" : { "x" : 1303, "y" : 204, "width" : 111, "height" : 22 }, "textPosition" : { "x" : 1318, "y" : 191 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1414, "y" : 204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1414, "y" : 204 } } }, "connectors" : [ { "edgeId" : 143463, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1312, "y" : 201 }, "to" : { "x" : 1254, "y" : 190 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143460, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143466, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1417, "y" : 215 }, "to" : { "x" : 1465, "y" : 215 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143476, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1352, "y" : 229 }, "to" : { "x" : 1306, "y" : 321 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143461, "reactomeId" : 10546323, "displayName" : "EML4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1163, "y" : 218 }, "minX" : 1143, "maxX" : 1229, "minY" : 201, "maxY" : 229, "prop" : { "x" : 1143, "y" : 207, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 1143, "y" : 207 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1183, "y" : 207 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1183, "y" : 207 } } }, "connectors" : [ { "edgeId" : 143460, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1217, "y" : 212 }, "b" : { "x" : 1229, "y" : 224 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1223, "y" : 218 } } } } ] }, { "id" : 143467, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1440, "y" : 161 }, "minX" : 1420, "maxX" : 1465, "minY" : 147, "maxY" : 215, "prop" : { "x" : 1420, "y" : 148, "width" : 40, "height" : 26 }, "textPosition" : { "x" : 1424, "y" : 150 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1455, "y" : 153 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1455, "y" : 153 } } }, "connectors" : [ { "edgeId" : 143466, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1446, "y" : 177 }, "to" : { "x" : 1465, "y" : 215 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1449, "y" : 190 }, "b" : { "x" : 1461, "y" : 202 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1455, "y" : 196 } } } } ] }, { "id" : 143464, "reactomeId" : 10546430, "displayName" : "EML4 homotrimer:Microtubule", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1248, "y" : 75 }, "minX" : 1191, "maxX" : 1312, "minY" : 51, "maxY" : 93, "prop" : { "x" : 1191, "y" : 57, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 1206, "y" : 44 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1306, "y" : 57 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1306, "y" : 57 } } }, "connectors" : [ { "edgeId" : 143463, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143465, "reactomeId" : 10505765, "displayName" : "p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1524, "y" : 114 }, "minX" : 1263, "maxX" : 1586, "minY" : 83, "maxY" : 208, "prop" : { "x" : 1468, "y" : 89, "width" : 112, "height" : 50 }, "textPosition" : { "x" : 1468, "y" : 90 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1580, "y" : 89 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1580, "y" : 89 } } }, "connectors" : [ { "edgeId" : 143463, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1465, "y" : 120 }, "to" : { "x" : 1263, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1263, "y" : 139 }, "b" : { "x" : 1263, "y" : 147 }, "c" : { "x" : 1263, "y" : 143 }, "type" : "STOP", "centre" : { "x" : 1263, "y" : 143 } } }, { "edgeId" : 143466, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1524, "y" : 142 }, "to" : { "x" : 1525, "y" : 200 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1525, "y" : 204 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1525, "y" : 204 } } } ] }, { "id" : 143471, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1717, "y" : 351 }, "minX" : 1687, "maxX" : 1739, "minY" : 293, "maxY" : 362, "prop" : { "x" : 1696, "y" : 340, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 1701, "y" : 340 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1733, "y" : 345 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1733, "y" : 345 } } }, "connectors" : [ { "edgeId" : 143470, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1711, "y" : 337 }, "to" : { "x" : 1687, "y" : 293 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1693, "y" : 309 }, "b" : { "x" : 1705, "y" : 321 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1699, "y" : 315 } } } } ] }, { "id" : 143468, "reactomeId" : 10546439, "displayName" : "p-S,T-EML4 homotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1714, "y" : 202 }, "minX" : 1590, "maxX" : 1798, "minY" : 184, "maxY" : 215, "prop" : { "x" : 1637, "y" : 190, "width" : 155, "height" : 25 }, "textPosition" : { "x" : 1639, "y" : 194 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1792, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1792, "y" : 190 } } }, "connectors" : [ { "edgeId" : 143466, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1634, "y" : 207 }, "to" : { "x" : 1590, "y" : 211 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1627, "y" : 212 }, "b" : { "x" : 1634, "y" : 207 }, "c" : { "x" : 1627, "y" : 204 }, "type" : "ARROW", "centre" : { "x" : 1627, "y" : 204 } } } ] }, { "id" : 143469, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1610, "y" : 152 }, "minX" : 1590, "maxX" : 1632, "minY" : 137, "maxY" : 211, "prop" : { "x" : 1590, "y" : 138, "width" : 41, "height" : 29 }, "textPosition" : { "x" : 1594, "y" : 142 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1626, "y" : 143 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1626, "y" : 143 } } }, "connectors" : [ { "edgeId" : 143466, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1605, "y" : 170 }, "to" : { "x" : 1590, "y" : 211 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1591, "y" : 184 }, "b" : { "x" : 1603, "y" : 196 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1597, "y" : 190 } } }, "endShape" : { "a" : { "x" : 1606, "y" : 178 }, "b" : { "x" : 1605, "y" : 170 }, "c" : { "x" : 1599, "y" : 175 }, "type" : "ARROW", "centre" : { "x" : 1599, "y" : 175 } } } ] }, { "id" : 143474, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1565, "y" : 356 }, "minX" : 1543, "maxX" : 1603, "minY" : 298, "maxY" : 369, "prop" : { "x" : 1543, "y" : 344, "width" : 45, "height" : 25 }, "textPosition" : { "x" : 1549, "y" : 346 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1583, "y" : 349 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1583, "y" : 349 } } }, "connectors" : [ { "edgeId" : 143470, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1573, "y" : 341 }, "to" : { "x" : 1603, "y" : 298 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1582, "y" : 313 }, "b" : { "x" : 1594, "y" : 325 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1588, "y" : 319 } } }, "endShape" : { "a" : { "x" : 1574, "y" : 333 }, "b" : { "x" : 1573, "y" : 341 }, "c" : { "x" : 1580, "y" : 338 }, "type" : "ARROW", "centre" : { "x" : 1580, "y" : 338 } } } ] }, { "id" : 143475, "reactomeId" : 10457003, "displayName" : "phospho-p-T210-PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1652, "y" : 429 }, "minX" : 1604, "maxX" : 1707, "minY" : 306, "maxY" : 440, "prop" : { "x" : 1604, "y" : 418, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 1613, "y" : 412 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1701, "y" : 418 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1701, "y" : 418 } } }, "connectors" : [ { "edgeId" : 143470, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1651, "y" : 415 }, "to" : { "x" : 1647, "y" : 314 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1647, "y" : 310 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1647, "y" : 310 } } } ] }, { "id" : 143472, "reactomeId" : 10457008, "displayName" : "NUDC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1766, "y" : 292 }, "minX" : 1687, "maxX" : 1794, "minY" : 275, "maxY" : 303, "prop" : { "x" : 1745, "y" : 281, "width" : 43, "height" : 22 }, "textPosition" : { "x" : 1745, "y" : 281 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1788, "y" : 281 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1788, "y" : 281 } } }, "connectors" : [ { "edgeId" : 143470, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1742, "y" : 292 }, "to" : { "x" : 1687, "y" : 293 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143473, "reactomeId" : 10457012, "displayName" : "phospho-NUDC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1489, "y" : 300 }, "minX" : 1306, "maxX" : 1603, "minY" : 282, "maxY" : 321, "prop" : { "x" : 1424, "y" : 288, "width" : 130, "height" : 25 }, "textPosition" : { "x" : 1438, "y" : 290 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1554, "y" : 288 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1554, "y" : 288 } } }, "connectors" : [ { "edgeId" : 143470, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1557, "y" : 298 }, "to" : { "x" : 1603, "y" : 298 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1564, "y" : 294 }, "b" : { "x" : 1557, "y" : 298 }, "c" : { "x" : 1564, "y" : 302 }, "type" : "ARROW", "centre" : { "x" : 1564, "y" : 302 } } }, { "edgeId" : 143476, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1421, "y" : 307 }, "to" : { "x" : 1306, "y" : 321 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143479, "reactomeId" : 10552293, "displayName" : "FIRRM", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1126, "y" : 589 }, "minX" : 1103, "maxX" : 1190, "minY" : 572, "maxY" : 646, "prop" : { "x" : 1103, "y" : 578, "width" : 46, "height" : 23 }, "textPosition" : { "x" : 1104, "y" : 579 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1149, "y" : 578 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1149, "y" : 578 } } }, "connectors" : [ { "edgeId" : 143478, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1152, "y" : 583 }, "to" : { "x" : 1190, "y" : 574 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143486, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1131, "y" : 604 }, "to" : { "x" : 1152, "y" : 646 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143477, "reactomeId" : 10546445, "displayName" : "p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1318, "y" : 438 }, "minX" : 1250, "maxX" : 1392, "minY" : 400, "maxY" : 471, "prop" : { "x" : 1250, "y" : 406, "width" : 136, "height" : 65 }, "textPosition" : { "x" : 1252, "y" : 408 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1386, "y" : 406 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1386, "y" : 406 } } }, "connectors" : [ { "edgeId" : 143476, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143483, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1393, "y" : 624 }, "minX" : 1374, "maxX" : 1414, "minY" : 587, "maxY" : 635, "prop" : { "x" : 1374, "y" : 614, "width" : 39, "height" : 21 }, "textPosition" : { "x" : 1378, "y" : 614 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1408, "y" : 619 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1408, "y" : 619 } } }, "connectors" : [ { "edgeId" : 143482, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1398, "y" : 611 }, "to" : { "x" : 1412, "y" : 587 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143480, "reactomeId" : 10457003, "displayName" : "phospho-p-T210-PLK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1154, "y" : 528 }, "minX" : 1064, "maxX" : 1548, "minY" : 511, "maxY" : 747, "prop" : { "x" : 1106, "y" : 517, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 1115, "y" : 511 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1203, "y" : 517 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1203, "y" : 517 } } }, "connectors" : [ { "edgeId" : 143489, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1103, "y" : 532 }, "to" : { "x" : 1073, "y" : 535 } }, { "from" : { "x" : 1073, "y" : 535 }, "to" : { "x" : 1064, "y" : 707 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143493, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1159, "y" : 542 }, "to" : { "x" : 1200, "y" : 626 } }, { "from" : { "x" : 1200, "y" : 626 }, "to" : { "x" : 1531, "y" : 686 } }, { "from" : { "x" : 1531, "y" : 686 }, "to" : { "x" : 1548, "y" : 747 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1166, "y" : 546 }, "b" : { "x" : 1159, "y" : 542 }, "c" : { "x" : 1158, "y" : 550 }, "type" : "ARROW", "centre" : { "x" : 1158, "y" : 550 } } }, { "edgeId" : 143478, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1162, "y" : 542 }, "to" : { "x" : 1190, "y" : 574 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143481, "reactomeId" : 10552295, "displayName" : "FIRRM:p-T210-PLK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1322, "y" : 585 }, "minX" : 1256, "maxX" : 1437, "minY" : 563, "maxY" : 601, "prop" : { "x" : 1256, "y" : 569, "width" : 132, "height" : 32 }, "textPosition" : { "x" : 1260, "y" : 580 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1388, "y" : 569 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1388, "y" : 569 } } }, "connectors" : [ { "edgeId" : 143478, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143482, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1391, "y" : 586 }, "to" : { "x" : 1412, "y" : 587 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143482, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1391, "y" : 571 }, "to" : { "x" : 1423, "y" : 565 } }, { "from" : { "x" : 1423, "y" : 565 }, "to" : { "x" : 1431, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1433, "y" : 584 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1433, "y" : 584 } } } ] }, { "id" : 143487, "reactomeId" : 10456709, "displayName" : "PPP1CC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1107, "y" : 672 }, "minX" : 1081, "maxX" : 1152, "minY" : 646, "maxY" : 719, "prop" : { "x" : 1081, "y" : 661, "width" : 52, "height" : 23 }, "textPosition" : { "x" : 1083, "y" : 655 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1133, "y" : 661 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1133, "y" : 661 } } }, "connectors" : [ { "edgeId" : 143489, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1107, "y" : 687 }, "to" : { "x" : 1108, "y" : 711 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1108, "y" : 715 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1108, "y" : 715 } } }, { "edgeId" : 143486, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1126, "y" : 658 }, "to" : { "x" : 1152, "y" : 646 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 143484, "reactomeId" : 10552302, "displayName" : "p-S43-FIRRM:p-T210-PLK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1559, "y" : 582 }, "minX" : 1473, "maxX" : 1612, "minY" : 558, "maxY" : 683, "prop" : { "x" : 1513, "y" : 564, "width" : 93, "height" : 37 }, "textPosition" : { "x" : 1515, "y" : 566 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1606, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1606, "y" : 564 } } }, "connectors" : [ { "edgeId" : 143493, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1558, "y" : 604 }, "to" : { "x" : 1556, "y" : 657 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 143493, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1552, "y" : 604 }, "to" : { "x" : 1536, "y" : 650 } }, { "from" : { "x" : 1536, "y" : 650 }, "to" : { "x" : 1546, "y" : 675 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1548, "y" : 679 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1548, "y" : 679 } } }, { "edgeId" : 143482, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1510, "y" : 587 }, "to" : { "x" : 1473, "y" : 592 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1504, "y" : 592 }, "b" : { "x" : 1510, "y" : 587 }, "c" : { "x" : 1503, "y" : 584 }, "type" : "ARROW", "centre" : { "x" : 1503, "y" : 584 } } } ] }, { "id" : 143485, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1494, "y" : 637 }, "minX" : 1473, "maxX" : 1515, "minY" : 592, "maxY" : 649, "prop" : { "x" : 1475, "y" : 625, "width" : 39, "height" : 24 }, "textPosition" : { "x" : 1478, "y" : 626 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1509, "y" : 630 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1509, "y" : 630 } } }, "connectors" : [ { "edgeId" : 143482, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1488, "y" : 622 }, "to" : { "x" : 1473, "y" : 592 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1481, "y" : 618 }, "b" : { "x" : 1488, "y" : 622 }, "c" : { "x" : 1488, "y" : 614 }, "type" : "ARROW", "centre" : { "x" : 1488, "y" : 614 } } } ] } ], "edges" : [ { "id" : 143458, "reactomeId" : 10471551, "displayName" : "Kinetochore capture of astral microtubules", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 968, "y" : 137 }, "minX" : 962, "maxX" : 974, "minY" : 107, "maxY" : 171, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 969, "y" : 107 }, "to" : { "x" : 968, "y" : 137 } }, { "from" : { "x" : 968, "y" : 137 }, "to" : { "x" : 968, "y" : 171 } } ], "endShape" : { "a" : { "x" : 964, "y" : 164 }, "b" : { "x" : 968, "y" : 171 }, "c" : { "x" : 972, "y" : 164 }, "type" : "ARROW", "centre" : { "x" : 972, "y" : 164 } }, "reactionShape" : { "c" : { "x" : 968, "y" : 137 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 968, "y" : 137 } }, "inputs" : [ { "id" : 143459, "points" : [ { "x" : 930, "y" : 105 } ] }, { "id" : 143456, "points" : [ { "x" : 1071, "y" : 76 } ], "stoichiometry" : 15 } ], "outputs" : [ { "id" : 143435 } ] }, { "id" : 143424, "reactomeId" : 10504365, "displayName" : "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 492, "y" : 387 }, "minX" : 486, "maxX" : 498, "minY" : 366, "maxY" : 411, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 492, "y" : 366 }, "to" : { "x" : 492, "y" : 387 } }, { "from" : { "x" : 492, "y" : 387 }, "to" : { "x" : 492, "y" : 411 } } ], "reactionShape" : { "a" : { "x" : 486, "y" : 381 }, "b" : { "x" : 498, "y" : 393 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 492, "y" : 387 } }, "inputs" : [ { "id" : 143425, "points" : [ { "x" : 444, "y" : 367 } ], "stoichiometry" : 3 }, { "id" : 143426, "points" : [ { "x" : 491, "y" : 346 } ] } ], "outputs" : [ { "id" : 143427, "points" : [ { "x" : 444, "y" : 416 } ], "stoichiometry" : 3 }, { "id" : 143416, "points" : [ { "x" : 493, "y" : 451 } ] } ], "catalysts" : [ { "id" : 143428, "points" : [ { "x" : 549, "y" : 386 } ] } ] }, { "id" : 143489, "reactomeId" : 10552332, "displayName" : "PPP1CC dephosphorylates PLK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1109, "y" : 727 }, "minX" : 1064, "maxX" : 1148, "minY" : 707, "maxY" : 735, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1064, "y" : 707 }, "to" : { "x" : 1109, "y" : 727 } }, { "from" : { "x" : 1109, "y" : 727 }, "to" : { "x" : 1148, "y" : 735 } } ], "reactionShape" : { "a" : { "x" : 1103, "y" : 721 }, "b" : { "x" : 1115, "y" : 733 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1109, "y" : 727 } }, "inputs" : [ { "id" : 143480, "points" : [ { "x" : 1103, "y" : 532 }, { "x" : 1073, "y" : 535 } ] }, { "id" : 143490, "points" : [ { "x" : 1052, "y" : 731 } ] } ], "outputs" : [ { "id" : 143491, "points" : [ { "x" : 1219, "y" : 730 } ] }, { "id" : 143492, "points" : [ { "x" : 1232, "y" : 756 } ] } ], "catalysts" : [ { "id" : 143487, "points" : [ { "x" : 1107, "y" : 687 } ] } ], "inhibitors" : [ { "id" : 143488, "points" : [ { "x" : 1225, "y" : 699 } ] } ] }, { "id" : 143463, "reactomeId" : 10546432, "displayName" : "EML4 binds to microtubules", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1254, "y" : 144 }, "minX" : 1248, "maxX" : 1260, "minY" : 96, "maxY" : 190, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1254, "y" : 190 }, "to" : { "x" : 1254, "y" : 144 } }, { "from" : { "x" : 1254, "y" : 144 }, "to" : { "x" : 1249, "y" : 96 } } ], "endShape" : { "a" : { "x" : 1254, "y" : 102 }, "b" : { "x" : 1249, "y" : 96 }, "c" : { "x" : 1246, "y" : 103 }, "type" : "ARROW", "centre" : { "x" : 1246, "y" : 103 } }, "reactionShape" : { "c" : { "x" : 1254, "y" : 144 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1254, "y" : 144 } }, "inputs" : [ { "id" : 143456, "points" : [ { "x" : 1115, "y" : 76 } ] }, { "id" : 143462, "points" : [ { "x" : 1312, "y" : 201 } ] } ], "outputs" : [ { "id" : 143464 } ], "inhibitors" : [ { "id" : 143465, "points" : [ { "x" : 1465, "y" : 120 } ] } ] }, { "id" : 143460, "reactomeId" : 10546327, "displayName" : "EML4 trimerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1260, "y" : 218 }, "minX" : 1186, "maxX" : 1300, "minY" : 212, "maxY" : 224, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1186, "y" : 218 }, "to" : { "x" : 1260, "y" : 218 } }, { "from" : { "x" : 1260, "y" : 218 }, "to" : { "x" : 1300, "y" : 216 } } ], "endShape" : { "a" : { "x" : 1293, "y" : 220 }, "b" : { "x" : 1300, "y" : 216 }, "c" : { "x" : 1293, "y" : 212 }, "type" : "ARROW", "centre" : { "x" : 1293, "y" : 212 } }, "reactionShape" : { "c" : { "x" : 1260, "y" : 218 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1260, "y" : 218 } }, "inputs" : [ { "id" : 143461, "stoichiometry" : 3 } ], "outputs" : [ { "id" : 143462 } ] }, { "id" : 143493, "reactomeId" : 10552321, "displayName" : "PLK1 phosphorylates FIRMM at S744", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1552, "y" : 690 }, "minX" : 1546, "maxX" : 1558, "minY" : 657, "maxY" : 747, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1556, "y" : 657 }, "to" : { "x" : 1552, "y" : 690 } }, { "from" : { "x" : 1552, "y" : 690 }, "to" : { "x" : 1548, "y" : 747 } } ], "reactionShape" : { "a" : { "x" : 1546, "y" : 684 }, "b" : { "x" : 1558, "y" : 696 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1552, "y" : 690 } }, "inputs" : [ { "id" : 143484, "points" : [ { "x" : 1558, "y" : 604 } ] }, { "id" : 143494, "points" : [ { "x" : 1580, "y" : 656 } ] } ], "outputs" : [ { "id" : 143495, "points" : [ { "x" : 1489, "y" : 747 } ] }, { "id" : 143496, "points" : [ { "x" : 1616, "y" : 720 } ] }, { "id" : 143480, "points" : [ { "x" : 1159, "y" : 542 }, { "x" : 1200, "y" : 626 }, { "x" : 1531, "y" : 686 } ] } ], "catalysts" : [ { "id" : 143484, "points" : [ { "x" : 1552, "y" : 604 }, { "x" : 1536, "y" : 650 } ] } ] }, { "id" : 143429, "reactomeId" : 10504363, "displayName" : "CDK1 phosphorylates CDCA5 (Sororin) at centromeres", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 715, "y" : 386 }, "minX" : 709, "maxX" : 721, "minY" : 353, "maxY" : 408, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 716, "y" : 353 }, "to" : { "x" : 715, "y" : 386 } }, { "from" : { "x" : 715, "y" : 386 }, "to" : { "x" : 715, "y" : 408 } } ], "reactionShape" : { "a" : { "x" : 709, "y" : 380 }, "b" : { "x" : 721, "y" : 392 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 715, "y" : 386 } }, "inputs" : [ { "id" : 143430, "points" : [ { "x" : 717, "y" : 311 } ] }, { "id" : 143431, "points" : [ { "x" : 760, "y" : 355 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 143406, "points" : [ { "x" : 716, "y" : 447 } ] }, { "id" : 143432, "points" : [ { "x" : 758, "y" : 408 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 143428, "points" : [ { "x" : 660, "y" : 386 } ] } ] }, { "id" : 143466, "reactomeId" : 10546441, "displayName" : "NEK6 and NEK7 phosphorylate EML4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1525, "y" : 216 }, "minX" : 1465, "maxX" : 1590, "minY" : 210, "maxY" : 222, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1465, "y" : 215 }, "to" : { "x" : 1525, "y" : 216 } }, { "from" : { "x" : 1525, "y" : 216 }, "to" : { "x" : 1590, "y" : 211 } } ], "reactionShape" : { "a" : { "x" : 1519, "y" : 210 }, "b" : { "x" : 1531, "y" : 222 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1525, "y" : 216 } }, "inputs" : [ { "id" : 143462, "points" : [ { "x" : 1417, "y" : 215 } ] }, { "id" : 143467, "points" : [ { "x" : 1446, "y" : 177 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 143468, "points" : [ { "x" : 1634, "y" : 207 } ] }, { "id" : 143469, "points" : [ { "x" : 1605, "y" : 170 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 143465, "points" : [ { "x" : 1524, "y" : 142 } ] } ] }, { "id" : 143433, "reactomeId" : 10504483, "displayName" : "Kinetochore assembly", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 720, "y" : 183 }, "minX" : 714, "maxX" : 726, "minY" : 155, "maxY" : 213, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 719, "y" : 155 }, "to" : { "x" : 720, "y" : 183 } }, { "from" : { "x" : 720, "y" : 183 }, "to" : { "x" : 720, "y" : 213 } } ], "endShape" : { "a" : { "x" : 716, "y" : 206 }, "b" : { "x" : 720, "y" : 213 }, "c" : { "x" : 724, "y" : 206 }, "type" : "ARROW", "centre" : { "x" : 724, "y" : 206 } }, "reactionShape" : { "a" : { "x" : 714, "y" : 177 }, "b" : { "x" : 726, "y" : 189 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 720, "y" : 183 } }, "inputs" : [ { "id" : 143434, "points" : [ { "x" : 717, "y" : 122 } ] }, { "id" : 143435, "points" : [ { "x" : 900, "y" : 182 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 143430 } ] }, { "id" : 143470, "reactomeId" : 10457014, "displayName" : "PLK1 phosphorylates NUDC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1646, "y" : 298 }, "minX" : 1603, "maxX" : 1687, "minY" : 292, "maxY" : 304, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1687, "y" : 293 }, "to" : { "x" : 1646, "y" : 298 } }, { "from" : { "x" : 1646, "y" : 298 }, "to" : { "x" : 1603, "y" : 298 } } ], "reactionShape" : { "a" : { "x" : 1640, "y" : 292 }, "b" : { "x" : 1652, "y" : 304 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1646, "y" : 298 } }, "inputs" : [ { "id" : 143471, "points" : [ { "x" : 1711, "y" : 337 } ], "stoichiometry" : 2 }, { "id" : 143472, "points" : [ { "x" : 1742, "y" : 292 } ] } ], "outputs" : [ { "id" : 143473, "points" : [ { "x" : 1557, "y" : 298 } ] }, { "id" : 143474, "points" : [ { "x" : 1573, "y" : 341 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 143475, "points" : [ { "x" : 1651, "y" : 415 } ] } ] }, { "id" : 143436, "reactomeId" : 10504623, "displayName" : "Dephosphorylation of CK2-modified condensin I", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 954, "y" : 373 }, "minX" : 948, "maxX" : 960, "minY" : 351, "maxY" : 389, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 954, "y" : 351 }, "to" : { "x" : 954, "y" : 373 } }, { "from" : { "x" : 954, "y" : 373 }, "to" : { "x" : 954, "y" : 389 } } ], "reactionShape" : { "a" : { "x" : 948, "y" : 367 }, "b" : { "x" : 960, "y" : 379 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 954, "y" : 373 } }, "inputs" : [ { "id" : 143437, "points" : [ { "x" : 954, "y" : 337 } ] }, { "id" : 143438, "points" : [ { "x" : 919, "y" : 350 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 143439, "points" : [ { "x" : 955, "y" : 414 } ] }, { "id" : 143440, "points" : [ { "x" : 916, "y" : 389 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 143441, "points" : [ { "x" : 1003, "y" : 372 } ] } ] }, { "id" : 143405, "reactomeId" : 10494771, "displayName" : "Phosphorylation of cohesin by PLK1 at centromeres", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 716, "y" : 561 }, "minX" : 710, "maxX" : 722, "minY" : 528, "maxY" : 588, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 717, "y" : 528 }, "to" : { "x" : 716, "y" : 561 } }, { "from" : { "x" : 716, "y" : 561 }, "to" : { "x" : 717, "y" : 588 } } ], "reactionShape" : { "a" : { "x" : 710, "y" : 555 }, "b" : { "x" : 722, "y" : 567 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 716, "y" : 561 } }, "inputs" : [ { "id" : 143406, "points" : [ { "x" : 717, "y" : 505 } ] }, { "id" : 143407, "points" : [ { "x" : 684, "y" : 527 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 143408, "points" : [ { "x" : 679, "y" : 590 } ], "stoichiometry" : 2 }, { "id" : 143409, "points" : [ { "x" : 717, "y" : 626 } ] } ], "catalysts" : [ { "id" : 143410, "points" : [ { "x" : 637, "y" : 562 } ] } ] }, { "id" : 143442, "reactomeId" : 10504625, "displayName" : "CK2 phosphorylates condensin I subunits", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1117, "y" : 367 }, "minX" : 1111, "maxX" : 1123, "minY" : 308, "maxY" : 426, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1118, "y" : 426 }, "to" : { "x" : 1117, "y" : 367 } }, { "from" : { "x" : 1117, "y" : 367 }, "to" : { "x" : 1116, "y" : 308 } } ], "reactionShape" : { "a" : { "x" : 1111, "y" : 361 }, "b" : { "x" : 1123, "y" : 373 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1117, "y" : 367 } }, "inputs" : [ { "id" : 143443, "points" : [ { "x" : 1155, "y" : 426 } ], "stoichiometry" : 4 }, { "id" : 143439, "points" : [ { "x" : 1000, "y" : 427 } ] } ], "outputs" : [ { "id" : 143437, "points" : [ { "x" : 1010, "y" : 308 } ] }, { "id" : 143444, "points" : [ { "x" : 1159, "y" : 309 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 143445, "points" : [ { "x" : 1148, "y" : 365 } ] } ] }, { "id" : 143411, "reactomeId" : 10494778, "displayName" : "PP2A-B56 dephosphorylates centromeric cohesin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 718, "y" : 728 }, "minX" : 712, "maxX" : 724, "minY" : 709, "maxY" : 747, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 717, "y" : 709 }, "to" : { "x" : 718, "y" : 728 } }, { "from" : { "x" : 718, "y" : 728 }, "to" : { "x" : 718, "y" : 747 } } ], "reactionShape" : { "a" : { "x" : 712, "y" : 722 }, "b" : { "x" : 724, "y" : 734 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 718, "y" : 728 } }, "inputs" : [ { "id" : 143409, "points" : [ { "x" : 717, "y" : 694 } ] }, { "id" : 143412, "points" : [ { "x" : 768, "y" : 707 } ] } ], "outputs" : [ { "id" : 143413, "points" : [ { "x" : 715, "y" : 768 } ] }, { "id" : 143414, "points" : [ { "x" : 773, "y" : 747 } ] } ], "catalysts" : [ { "id" : 143409, "points" : [ { "x" : 698, "y" : 694 }, { "x" : 685, "y" : 715 } ] } ] }, { "id" : 143446, "reactomeId" : 10504774, "displayName" : "Deacetylation of cohesin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 262, "y" : 729 }, "minX" : 243, "maxX" : 287, "minY" : 723, "maxY" : 735, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 287, "y" : 728 }, "to" : { "x" : 262, "y" : 729 } }, { "from" : { "x" : 262, "y" : 729 }, "to" : { "x" : 243, "y" : 728 } } ], "reactionShape" : { "a" : { "x" : 256, "y" : 723 }, "b" : { "x" : 268, "y" : 735 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 262, "y" : 729 } }, "inputs" : [ { "id" : 143447, "points" : [ { "x" : 300, "y" : 706 } ], "stoichiometry" : 2 }, { "id" : 143421, "points" : [ { "x" : 314, "y" : 728 } ] } ], "outputs" : [ { "id" : 143448, "points" : [ { "x" : 195, "y" : 728 } ] }, { "id" : 143449, "points" : [ { "x" : 219, "y" : 701 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 143450, "points" : [ { "x" : 262, "y" : 664 } ] } ] }, { "id" : 143478, "reactomeId" : 10552297, "displayName" : "FIRRM binds PLK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1220, "y" : 582 }, "minX" : 1190, "maxX" : 1253, "minY" : 574, "maxY" : 588, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1190, "y" : 574 }, "to" : { "x" : 1220, "y" : 582 } }, { "from" : { "x" : 1220, "y" : 582 }, "to" : { "x" : 1253, "y" : 583 } } ], "endShape" : { "a" : { "x" : 1246, "y" : 587 }, "b" : { "x" : 1253, "y" : 583 }, "c" : { "x" : 1246, "y" : 579 }, "type" : "ARROW", "centre" : { "x" : 1246, "y" : 579 } }, "reactionShape" : { "c" : { "x" : 1220, "y" : 582 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1220, "y" : 582 } }, "inputs" : [ { "id" : 143479, "points" : [ { "x" : 1152, "y" : 583 } ] }, { "id" : 143480, "points" : [ { "x" : 1162, "y" : 542 } ] } ], "outputs" : [ { "id" : 143481 } ] }, { "id" : 143415, "reactomeId" : 10504199, "displayName" : "Phosphorylation of cohesin by PLK1 at chromosomal arms", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 493, "y" : 560 }, "minX" : 487, "maxX" : 499, "minY" : 533, "maxY" : 592, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 493, "y" : 533 }, "to" : { "x" : 493, "y" : 560 } }, { "from" : { "x" : 493, "y" : 560 }, "to" : { "x" : 494, "y" : 592 } } ], "reactionShape" : { "a" : { "x" : 487, "y" : 554 }, "b" : { "x" : 499, "y" : 566 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 493, "y" : 560 } }, "inputs" : [ { "id" : 143416, "points" : [ { "x" : 494, "y" : 506 } ] }, { "id" : 143417, "points" : [ { "x" : 461, "y" : 529 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 143418, "points" : [ { "x" : 451, "y" : 595 } ], "stoichiometry" : 2 }, { "id" : 143419, "points" : [ { "x" : 494, "y" : 638 } ] } ], "catalysts" : [ { "id" : 143410, "points" : [ { "x" : 534, "y" : 561 } ] } ] }, { "id" : 143476, "reactomeId" : 10546447, "displayName" : "EML4 recruits NUDC to mitotic spindle", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1310, "y" : 351 }, "minX" : 1304, "maxX" : 1316, "minY" : 321, "maxY" : 403, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1306, "y" : 321 }, "to" : { "x" : 1310, "y" : 351 } }, { "from" : { "x" : 1310, "y" : 351 }, "to" : { "x" : 1315, "y" : 403 } } ], "endShape" : { "a" : { "x" : 1310, "y" : 396 }, "b" : { "x" : 1315, "y" : 403 }, "c" : { "x" : 1318, "y" : 396 }, "type" : "ARROW", "centre" : { "x" : 1318, "y" : 396 } }, "reactionShape" : { "c" : { "x" : 1310, "y" : 351 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1310, "y" : 351 } }, "inputs" : [ { "id" : 143435, "points" : [ { "x" : 1015, "y" : 213 } ] }, { "id" : 143473, "points" : [ { "x" : 1421, "y" : 307 } ] }, { "id" : 143462, "points" : [ { "x" : 1352, "y" : 229 } ] } ], "outputs" : [ { "id" : 143477 } ] }, { "id" : 143482, "reactomeId" : 10552305, "displayName" : "PLK1 phosphorylates FIRRM at S43", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1439, "y" : 595 }, "minX" : 1412, "maxX" : 1473, "minY" : 587, "maxY" : 601, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1412, "y" : 587 }, "to" : { "x" : 1439, "y" : 595 } }, { "from" : { "x" : 1439, "y" : 595 }, "to" : { "x" : 1473, "y" : 592 } } ], "reactionShape" : { "a" : { "x" : 1433, "y" : 589 }, "b" : { "x" : 1445, "y" : 601 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1439, "y" : 595 } }, "inputs" : [ { "id" : 143481, "points" : [ { "x" : 1391, "y" : 586 } ] }, { "id" : 143483, "points" : [ { "x" : 1398, "y" : 611 } ] } ], "outputs" : [ { "id" : 143484, "points" : [ { "x" : 1510, "y" : 587 } ] }, { "id" : 143485, "points" : [ { "x" : 1488, "y" : 622 } ] } ], "catalysts" : [ { "id" : 143481, "points" : [ { "x" : 1391, "y" : 571 }, { "x" : 1423, "y" : 565 } ] } ] }, { "id" : 143451, "reactomeId" : 10473363, "displayName" : "Translocation of NuMA to the centrosomes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 199, "y" : 231 }, "minX" : 193, "maxX" : 205, "minY" : 202, "maxY" : 256, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 197, "y" : 202 }, "to" : { "x" : 199, "y" : 231 } }, { "from" : { "x" : 199, "y" : 231 }, "to" : { "x" : 199, "y" : 256 } } ], "endShape" : { "a" : { "x" : 195, "y" : 249 }, "b" : { "x" : 199, "y" : 256 }, "c" : { "x" : 203, "y" : 249 }, "type" : "ARROW", "centre" : { "x" : 203, "y" : 249 } }, "reactionShape" : { "c" : { "x" : 199, "y" : 231 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 199, "y" : 231 } }, "inputs" : [ { "id" : 143452, "points" : [ { "x" : 165, "y" : 182 } ] }, { "id" : 143453, "points" : [ { "x" : 234, "y" : 175 } ] } ], "outputs" : [ { "id" : 143454 } ] }, { "id" : 143486, "reactomeId" : 10552325, "displayName" : "FIRRM binds PPP1CC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1189, "y" : 665 }, "minX" : 1152, "maxX" : 1233, "minY" : 646, "maxY" : 675, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1152, "y" : 646 }, "to" : { "x" : 1189, "y" : 665 } }, { "from" : { "x" : 1189, "y" : 665 }, "to" : { "x" : 1233, "y" : 675 } } ], "endShape" : { "a" : { "x" : 1225, "y" : 677 }, "b" : { "x" : 1233, "y" : 675 }, "c" : { "x" : 1227, "y" : 670 }, "type" : "ARROW", "centre" : { "x" : 1227, "y" : 670 } }, "reactionShape" : { "c" : { "x" : 1189, "y" : 665 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1189, "y" : 665 } }, "inputs" : [ { "id" : 143479, "points" : [ { "x" : 1131, "y" : 604 } ] }, { "id" : 143487, "points" : [ { "x" : 1126, "y" : 658 } ] } ], "outputs" : [ { "id" : 143488 } ] }, { "id" : 143455, "reactomeId" : 10473357, "displayName" : "Association of NuMA with microtubules", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 253, "y" : 373 }, "minX" : 229, "maxX" : 259, "minY" : 333, "maxY" : 398, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 254, "y" : 333 }, "to" : { "x" : 253, "y" : 373 } }, { "from" : { "x" : 253, "y" : 373 }, "to" : { "x" : 229, "y" : 398 } } ], "endShape" : { "a" : { "x" : 231, "y" : 390 }, "b" : { "x" : 229, "y" : 398 }, "c" : { "x" : 237, "y" : 396 }, "type" : "ARROW", "centre" : { "x" : 237, "y" : 396 } }, "reactionShape" : { "c" : { "x" : 253, "y" : 373 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 253, "y" : 373 } }, "inputs" : [ { "id" : 143456, "points" : [ { "x" : 1056, "y" : 62 }, { "x" : 397, "y" : 62 }, { "x" : 341, "y" : 303 } ] }, { "id" : 143454, "points" : [ { "x" : 224, "y" : 309 } ] } ], "outputs" : [ { "id" : 143457 } ] }, { "id" : 143420, "reactomeId" : 10504260, "displayName" : "Resolution of sister chromatids", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 497, "y" : 727 }, "minX" : 491, "maxX" : 503, "minY" : 695, "maxY" : 739, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 495, "y" : 695 }, "to" : { "x" : 497, "y" : 727 } }, { "from" : { "x" : 497, "y" : 727 }, "to" : { "x" : 497, "y" : 739 } } ], "reactionShape" : { "c" : { "x" : 497, "y" : 727 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 497, "y" : 727 } }, "inputs" : [ { "id" : 143419 } ], "outputs" : [ { "id" : 143421, "points" : [ { "x" : 420, "y" : 733 } ] }, { "id" : 143422, "points" : [ { "x" : 377, "y" : 770 } ] }, { "id" : 143423, "points" : [ { "x" : 497, "y" : 804 } ], "stoichiometry" : 2 } ] } ], "compartments" : [ { "id" : 143497, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 933, "y" : 456 }, "minX" : 0, "maxX" : 1866, "minY" : 0, "maxY" : 912, "prop" : { "x" : 0, "y" : 0, "width" : 1866, "height" : 912 }, "textPosition" : { "x" : 25, "y" : 857 }, "insets" : { "x" : 10, "y" : 10, "width" : 1846, "height" : 892 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 143459, 143435, 143405, 143426, 143409, 143419, 143411, 143412, 143414, 143408, 143415, 143418, 143420, 143423, 143498, 143416, 143417, 143406, 143407, 143424, 143425, 143427, 143428, 143429, 143434, 143432, 143503, 143504, 143421, 143422, 143433, 143430, 143431, 143413, 143439, 143436, 143437, 143438, 143441, 143440, 143442, 143444, 143445, 143446, 143447, 143448, 143449, 143450, 143501, 143505, 143506, 143451, 143452, 143454, 143457, 143453, 143502, 143507, 143455, 143456, 143458, 143460, 143461, 143462, 143463, 143464, 143443, 143466, 143467, 143468, 143469, 143470, 143471, 143472, 143473, 143474, 143475, 143476, 143477, 143465, 143508, 143410, 143478, 143479, 143481, 143482, 143483, 143484, 143485, 143480, 143486, 143487, 143488, 143489, 143490, 143491, 143492, 143493, 143494, 143495, 143496 ] } ], "notes" : [ ], "links" : [ { "id" : 143507, "renderableClass" : "Interaction", "position" : { "x" : 122, "y" : 111 }, "minX" : 116, "maxX" : 128, "minY" : 90, "maxY" : 133, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 122, "y" : 90 }, "to" : { "x" : 122, "y" : 133 } } ], "endShape" : { "a" : { "x" : 118, "y" : 126 }, "b" : { "x" : 122, "y" : 133 }, "c" : { "x" : 126, "y" : 126 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 126, "y" : 126 } }, "reactionShape" : { "a" : { "x" : 116, "y" : 105 }, "b" : { "x" : 128, "y" : 117 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 122, "y" : 111 } }, "inputs" : [ { "id" : 143502 } ], "outputs" : [ { "id" : 143452 } ] }, { "id" : 143504, "renderableClass" : "Interaction", "position" : { "x" : 579, "y" : 102 }, "minX" : 541, "maxX" : 618, "minY" : 96, "maxY" : 108, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 541, "y" : 103 }, "to" : { "x" : 618, "y" : 101 } } ], "endShape" : { "a" : { "x" : 611, "y" : 105 }, "b" : { "x" : 618, "y" : 101 }, "c" : { "x" : 611, "y" : 97 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 611, "y" : 97 } }, "reactionShape" : { "a" : { "x" : 573, "y" : 96 }, "b" : { "x" : 585, "y" : 108 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 579, "y" : 102 } }, "inputs" : [ { "id" : 143498 } ], "outputs" : [ { "id" : 143434 } ] }, { "id" : 143505, "renderableClass" : "Interaction", "position" : { "x" : 877, "y" : 801 }, "minX" : 805, "maxX" : 949, "minY" : 795, "maxY" : 807, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 805, "y" : 801 }, "to" : { "x" : 949, "y" : 801 } } ], "endShape" : { "a" : { "x" : 942, "y" : 805 }, "b" : { "x" : 949, "y" : 801 }, "c" : { "x" : 942, "y" : 797 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 942, "y" : 797 } }, "reactionShape" : { "a" : { "x" : 871, "y" : 795 }, "b" : { "x" : 883, "y" : 807 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 877, "y" : 801 } }, "inputs" : [ { "id" : 143413 } ], "outputs" : [ { "id" : 143501 } ] }, { "id" : 143508, "renderableClass" : "Interaction", "position" : { "x" : 822, "y" : 23 }, "minX" : 121, "maxX" : 1523, "minY" : 17, "maxY" : 86, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 122, "y" : 48 }, "to" : { "x" : 121, "y" : 21 } }, { "from" : { "x" : 121, "y" : 21 }, "to" : { "x" : 1523, "y" : 25 } }, { "from" : { "x" : 1523, "y" : 25 }, "to" : { "x" : 1523, "y" : 86 } } ], "endShape" : { "a" : { "x" : 1519, "y" : 79 }, "b" : { "x" : 1523, "y" : 86 }, "c" : { "x" : 1527, "y" : 79 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1527, "y" : 79 } }, "reactionShape" : { "a" : { "x" : 816, "y" : 17 }, "b" : { "x" : 828, "y" : 29 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 822, "y" : 23 } }, "inputs" : [ { "id" : 143502 } ], "outputs" : [ { "id" : 143465 } ] }, { "id" : 143503, "renderableClass" : "Interaction", "position" : { "x" : 490, "y" : 197 }, "minX" : 484, "maxX" : 496, "minY" : 132, "maxY" : 263, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 490, "y" : 132 }, "to" : { "x" : 490, "y" : 263 } } ], "endShape" : { "a" : { "x" : 486, "y" : 256 }, "b" : { "x" : 490, "y" : 263 }, "c" : { "x" : 494, "y" : 256 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 494, "y" : 256 } }, "reactionShape" : { "a" : { "x" : 484, "y" : 191 }, "b" : { "x" : 496, "y" : 203 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 490, "y" : 197 } }, "inputs" : [ { "id" : 143498 } ], "outputs" : [ { "id" : 143426 } ] } ], "shadows" : [ { "id" : 143510, "reactomeId" : 10557137, "displayName" : "Recruitment of NuMA to mitotic centrosomes", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 615, "y" : 252 }, "minX" : 72, "maxX" : 1158, "minY" : 42, "maxY" : 462, "prop" : { "x" : 72, "y" : 42, "width" : 1086, "height" : 420 }, "points" : [ { "x" : 72, "y" : 42 }, { "x" : 1158, "y" : 42 }, { "x" : 1158, "y" : 462 }, { "x" : 72, "y" : 462 } ], "colour" : "#dc3912" }, { "id" : 143511, "reactomeId" : 10557845, "displayName" : "Resolution of Sister Chromatid Cohesion", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 882, "y" : 457 }, "minX" : 90, "maxX" : 1674, "minY" : 71, "maxY" : 843, "prop" : { "x" : 90, "y" : 481, "width" : 1584, "height" : 362 }, "points" : [ { "x" : 90, "y" : 71 }, { "x" : 1674, "y" : 71 }, { "x" : 1674, "y" : 843 }, { "x" : 90, "y" : 843 } ], "colour" : "#008000" }, { "id" : 143509, "reactomeId" : 10556281, "displayName" : "EML4 and NUDC in mitotic spindle formation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1347, "y" : 261 }, "minX" : 893, "maxX" : 1802, "minY" : 42, "maxY" : 481, "prop" : { "x" : 893, "y" : 42, "width" : 909, "height" : 439 }, "points" : [ { "x" : 893, "y" : 42 }, { "x" : 1802, "y" : 42 }, { "x" : 1802, "y" : 481 }, { "x" : 893, "y" : 481 } ], "colour" : "#4684ee" }, { "id" : 143512, "reactomeId" : 10558005, "displayName" : "Condensation of Prometaphase Chromosomes", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1045, "y" : 362 }, "minX" : 868, "maxX" : 1222, "minY" : 275, "maxY" : 449, "prop" : { "x" : 868, "y" : 275, "width" : 354, "height" : 174 }, "points" : [ { "x" : 868, "y" : 275 }, { "x" : 1222, "y" : 275 }, { "x" : 1222, "y" : 449 }, { "x" : 868, "y" : 449 } ], "colour" : "#666666" } ], "minX" : 0, "maxX" : 1866, "minY" : 0, "maxY" : 912, "disease" : false }