{ "dbId" : 10445728, "stId" : "R-BTA-6806834", "speciesName" : "Bos taurus", "nodes" : [ { "dbId" : 10359966, "stId" : "R-BTA-2127343", "displayName" : "4-hydroxyprolyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10423967, "stId" : "R-BTA-8875657", "displayName" : "GGC-RAB4 [recycling endosome membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "parents" : [ 10423969 ], "children" : [ 10423963, 10423965 ] }, { "dbId" : 10420381, "stId" : "R-BTA-8851839", "displayName" : "HGF:p-4Y MET dimer:MUC20 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46155 ], "parents" : [ ], "children" : [ 10388474, 10420379 ] }, { "dbId" : 10359964, "stId" : "R-BTA-2127444", "displayName" : "4-Hyp Glu-Gal-Hyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10423965, "stId" : "R-BTA-8875675", "displayName" : "RAB4B [recycling endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MCK4", "standardIdentifier" : "uniprot:F1MCK4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RAB4B" ], "parents" : [ 10423967 ], "children" : [ ] }, { "dbId" : 10420379, "stId" : "R-BTA-8851833", "displayName" : "MUC20 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46162 ], "identifier" : "A0A3Q1M6U9", "standardIdentifier" : "uniprot:A0A3Q1M6U9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MUC20" ], "parents" : [ 10420381 ], "children" : [ ] }, { "dbId" : 10359962, "stId" : "R-BTA-2127424", "displayName" : "3x4Hyp-5Hyl-COL5A2(?-1229) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10423963, "stId" : "R-BTA-8875666", "displayName" : "GGC-RAB4A [recycling endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Q2TBH7", "standardIdentifier" : "uniprot:Q2TBH7", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423967 ], "children" : [ ] }, { "dbId" : 10359960, "stId" : "R-BTA-2127357", "displayName" : "4-Hyp 5-Gal-Hyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10423961, "stId" : "R-BTA-8875665", "displayName" : "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46271 ], "parents" : [ ], "children" : [ 10421057, 10423959, 10423933 ] }, { "dbId" : 10359958, "stId" : "R-BTA-2127372", "displayName" : "3,4-hydroxyprolyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10423959, "stId" : "R-BTA-8875655", "displayName" : "GGA3 [recycling endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1N3P7", "standardIdentifier" : "uniprot:A0A3Q1N3P7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "GGA3" ], "parents" : [ 10423961 ], "children" : [ ] }, { "dbId" : 10359956, "stId" : "R-BTA-2127302", "displayName" : "3,4-Hyp Glu-Gal-Hyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10359953, "stId" : "R-BTA-2127378", "displayName" : "3,4-Hyp 5-Hyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10359950, "stId" : "R-BTA-2127320", "displayName" : "3,4-Hyp 5-Gal-Hyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10423946, "stId" : "R-BTA-8875574", "displayName" : "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46267 ], "parents" : [ ], "children" : [ 10423944, 10423933 ] }, { "dbId" : 10423944, "stId" : "R-BTA-8875579", "displayName" : "(DOCK7) [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "diagramIds" : [ 46266 ], "parents" : [ 10423946 ], "children" : [ 10374503 ] }, { "dbId" : 10423937, "stId" : "R-BTA-8875561", "displayName" : "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46259 ], "parents" : [ ], "children" : [ 10346003, 10423933 ] }, { "dbId" : 10443392, "stId" : "R-BTA-1257604", "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "speciesId" : 48898, "diagramIds" : [ 46289 ] }, { "dbId" : 10357438, "stId" : "R-BTA-210625", "displayName" : "PTPN1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A6QQN2", "standardIdentifier" : "uniprot:A6QQN2", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10416724 ], "children" : [ ] }, { "dbId" : 10352830, "stId" : "R-BTA-54851", "displayName" : "FN1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "G5E5A9", "standardIdentifier" : "uniprot:G5E5A9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FN1" ], "parents" : [ 10352832 ], "children" : [ ] }, { "dbId" : 10420405, "stId" : "R-BTA-8851882", "displayName" : "HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46173 ], "parents" : [ ], "children" : [ 10390530, 10388474 ] }, { "dbId" : 10359985, "stId" : "R-BTA-2268628", "displayName" : "COL5A3 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MJQ6", "standardIdentifier" : "uniprot:F1MJQ6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL5A3" ], "parents" : [ 10360011, 10360013 ], "children" : [ ] }, { "dbId" : 10377900, "stId" : "R-BTA-2192862", "displayName" : "COL11A1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1N0K0", "standardIdentifier" : "uniprot:F1N0K0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL11A1" ], "parents" : [ 10377948 ], "children" : [ ] }, { "dbId" : 10420395, "stId" : "R-BTA-8851868", "displayName" : "HGF:p-4Y-MET dimer:RANBP10 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46167 ], "parents" : [ ], "children" : [ 10420393, 10388474 ] }, { "dbId" : 10359978, "stId" : "R-BTA-2127308", "displayName" : "Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10360015 ], "children" : [ 10359976, 10359919 ] }, { "dbId" : 10423978, "stId" : "R-BTA-8875815", "displayName" : "HGF:p-4Y-MET dimer:STAT3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46276 ], "parents" : [ ], "children" : [ 10359395, 10388474 ] }, { "dbId" : 10420393, "stId" : "R-BTA-8851865", "displayName" : "RANBP10 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46169 ], "identifier" : "A0A3Q1MPW0", "standardIdentifier" : "uniprot:A0A3Q1MPW0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RANBP10" ], "parents" : [ 10420395 ], "children" : [ ] }, { "dbId" : 10359976, "stId" : "R-BTA-2127360", "displayName" : "Collagen alpha-2(V) chains [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "parents" : [ 10360011, 10359978 ], "children" : [ 10359953, 10359968, 10359970, 10359972, 10359956, 10359974, 10359958, 10359960, 10359962, 10359964, 10359966, 10359950 ] }, { "dbId" : 10359974, "stId" : "R-BTA-375066", "displayName" : "Collagen alpha-2(V) chain C-terminal fragment [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10423974, "stId" : "R-BTA-8854137", "displayName" : "GGA3 [early endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46270 ], "identifier" : "A0A3Q1N3P7", "standardIdentifier" : "uniprot:A0A3Q1N3P7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "GGA3" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10359972, "stId" : "R-BTA-2127374", "displayName" : "Glu-Gal-Hyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10359970, "stId" : "R-BTA-2127316", "displayName" : "5-hydroxylysyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10359968, "stId" : "R-BTA-2127334", "displayName" : "5-Gal-Hyl collagen alpha-2(V) chain [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MDT9", "standardIdentifier" : "uniprot:A0A3Q1MDT9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359976 ], "children" : [ ] }, { "dbId" : 10423969, "stId" : "R-BTA-8875670", "displayName" : "GGC-RAB4:GTP [recycling endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46273 ], "parents" : [ ], "children" : [ 29438, 10423967 ] }, { "dbId" : 10347740, "stId" : "R-BTA-182925", "displayName" : "STAM [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F6RS49", "standardIdentifier" : "uniprot:F6RS49", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10347746 ], "children" : [ ] }, { "dbId" : 10377948, "stId" : "R-BTA-2142910", "displayName" : "Tropocollagen type XI [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10377985 ], "children" : [ 10377924, 10355012, 10377900 ] }, { "dbId" : 10347736, "stId" : "R-BTA-182954", "displayName" : "HGS [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Q0V8S0", "standardIdentifier" : "uniprot:Q0V8S0", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10347748 ], "children" : [ ] }, { "dbId" : 10347732, "stId" : "R-BTA-182920", "displayName" : "EPS15 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A5D7I1", "standardIdentifier" : "uniprot:A5D7I1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "EPS15" ], "parents" : [ 10347748 ], "children" : [ ] }, { "dbId" : 10360017, "stId" : "R-BTA-1609685", "displayName" : "Collagen V [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388013 ], "children" : [ 10360015 ] }, { "dbId" : 10360015, "stId" : "R-BTA-2127422", "displayName" : "Tropocollagen type V [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "parents" : [ 10360017 ], "children" : [ 10360011, 10359978, 10360013 ] }, { "dbId" : 10360013, "stId" : "R-BTA-2127296", "displayName" : "Tropocollagen alpha-3(V) [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10360015 ], "children" : [ 10359985 ] }, { "dbId" : 10360011, "stId" : "R-BTA-2127310", "displayName" : "Tropocollagen alpha-1-3(V) [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10360015 ], "children" : [ 10359985, 10359976, 10359919 ] }, { "dbId" : 10420425, "stId" : "R-BTA-8851934", "displayName" : "HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "diagramIds" : [ 46188 ], "parents" : [ ], "children" : [ 10420417, 10420421 ] }, { "dbId" : 10377924, "stId" : "R-BTA-2192871", "displayName" : "COL11A2 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MRP6", "standardIdentifier" : "uniprot:F1MRP6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL11A2" ], "parents" : [ 10377948 ], "children" : [ ] }, { "dbId" : 10420421, "stId" : "R-BTA-8851921", "displayName" : "HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46186 ], "parents" : [ 10420425 ], "children" : [ 10337681, 10339761, 10388474 ] }, { "dbId" : 10352832, "stId" : "R-BTA-266103", "displayName" : "FN1 dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10355062 ], "children" : [ 10352830 ] }, { "dbId" : 10420417, "stId" : "R-BTA-8851913", "displayName" : "HGF:p-4Y-MET dimer:GAB1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46183 ], "parents" : [ 10420425 ], "children" : [ 10339761, 10388474 ] }, { "dbId" : 10347714, "stId" : "R-BTA-112199", "displayName" : "CBL [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1LN00", "standardIdentifier" : "uniprot:A0A3Q1LN00", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CBL" ], "parents" : [ 10423727, 10423731, 10347876 ], "children" : [ ] }, { "dbId" : 10347772, "stId" : "R-BTA-8867734", "displayName" : "SH3GL3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MX23", "standardIdentifier" : "uniprot:F1MX23", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SH3GL3" ], "parents" : [ 10347774 ], "children" : [ ] }, { "dbId" : 10377981, "stId" : "R-BTA-2152344", "displayName" : "Tropocollagen type XXVII [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10377987 ], "children" : [ 10377955 ] }, { "dbId" : 10347774, "stId" : "R-BTA-8867739", "displayName" : "SH3GL3 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10347776 ], "children" : [ 10347772 ] }, { "dbId" : 10404603, "stId" : "R-BTA-8851807", "displayName" : "HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46154 ], "parents" : [ ], "children" : [ 10337687, 10388474 ] }, { "dbId" : 10347768, "stId" : "R-BTA-8867743", "displayName" : "SH3GL1 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10347776 ], "children" : [ 10347766 ] }, { "dbId" : 10404601, "stId" : "R-BTA-8851860", "displayName" : "HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46166 ], "parents" : [ ], "children" : [ 10404599, 10337685, 10388474 ] }, { "dbId" : 10404599, "stId" : "R-BTA-374586", "displayName" : "RANBP9 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46165 ], "identifier" : "A0A3Q1MPB6", "standardIdentifier" : "uniprot:A0A3Q1MPB6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RANBP9" ], "parents" : [ 10404601 ], "children" : [ ] }, { "dbId" : 10347766, "stId" : "R-BTA-8867732", "displayName" : "SH3GL1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Q2KJA1", "standardIdentifier" : "uniprot:Q2KJA1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SH3GL1" ], "parents" : [ 10347768 ], "children" : [ ] }, { "dbId" : 10404595, "stId" : "R-BTA-8851897", "displayName" : "HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46179 ], "parents" : [ ], "children" : [ 10404593, 10337687 ] }, { "dbId" : 10347760, "stId" : "R-BTA-182958", "displayName" : "SH3GL2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Q08DX1", "standardIdentifier" : "uniprot:Q08DX1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SH3GL2" ], "parents" : [ 10347762 ], "children" : [ ] }, { "dbId" : 10404593, "stId" : "R-BTA-8851891", "displayName" : "HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46176 ], "parents" : [ 10404595 ], "children" : [ 10388474, 10404591 ] }, { "dbId" : 10347762, "stId" : "R-BTA-8867741", "displayName" : "SH3GL2 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10347776 ], "children" : [ 10347760 ] }, { "dbId" : 10404591, "stId" : "R-BTA-8851895", "displayName" : "phospho-SHC1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Q0IIE2", "standardIdentifier" : "uniprot:Q0IIE2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SHC1" ], "parents" : [ 10404593 ], "children" : [ ] }, { "dbId" : 10347756, "stId" : "R-BTA-182957", "displayName" : "SH3KBP1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1M839", "standardIdentifier" : "uniprot:A0A3Q1M839", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SH3KBP1" ], "parents" : [ 10347758 ], "children" : [ ] }, { "dbId" : 10347758, "stId" : "R-BTA-8875475", "displayName" : "SH3KBP1 tetramer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10347778 ], "children" : [ 10347756 ] }, { "dbId" : 10347748, "stId" : "R-BTA-182947", "displayName" : "EPS15:HGS:STAM [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46246 ], "parents" : [ 10423911 ], "children" : [ 10347746, 10347732, 10347736 ] }, { "dbId" : 179838, "stId" : "R-ALL-179838", "displayName" : "PI(3,4,5)P3 [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46198 ], "identifier" : "57836", "standardIdentifier" : "chebi:57836", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10377955, "stId" : "R-BTA-2192991", "displayName" : "COL27A1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1M646", "standardIdentifier" : "uniprot:A0A3Q1M646", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL27A1" ], "parents" : [ 10377981 ], "children" : [ ] }, { "dbId" : 10347744, "stId" : "R-BTA-182965", "displayName" : "STAM2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "G3N315", "standardIdentifier" : "uniprot:G3N315", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "STAM2" ], "parents" : [ 10347746 ], "children" : [ ] }, { "dbId" : 10347746, "stId" : "R-BTA-182929", "displayName" : "STAM [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "parents" : [ 10347748 ], "children" : [ 10347744, 10347740 ] }, { "dbId" : 10346013, "stId" : "R-BTA-9647915", "displayName" : "KRAS [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "E1BMX0", "standardIdentifier" : "uniprot:E1BMX0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KRAS" ], "parents" : [ 10346031 ], "children" : [ ] }, { "dbId" : 10415132, "stId" : "R-BTA-9734108", "displayName" : "Anti-MET MAbs:MET [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46136 ], "parents" : [ ], "children" : [ 10361641, 9734118 ] }, { "dbId" : 10415130, "stId" : "R-BTA-6800287", "displayName" : "HGF dimer:MET [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46135 ], "parents" : [ 10416681 ], "children" : [ 10367351, 10361641 ] }, { "dbId" : 10347547, "stId" : "R-BTA-1806218", "displayName" : "PIK3CA:PIK3R1 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46193 ], "parents" : [ 10388482 ], "children" : [ 10337705, 10337695 ] }, { "dbId" : 10374681, "stId" : "R-BTA-914048", "displayName" : "phospho-STAT3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46280 ], "identifier" : "F1MX38", "standardIdentifier" : "uniprot:F1MX38", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "STAT3" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10415126, "stId" : "R-BTA-6800218", "displayName" : "HGF [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46125 ], "identifier" : "F1MZD6", "standardIdentifier" : "uniprot:F1MZD6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HGF" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10346003, "stId" : "R-BTA-913472", "displayName" : "RAPGEF1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46258 ], "identifier" : "A0A3Q1LPP9", "standardIdentifier" : "uniprot:A0A3Q1LPP9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RAPGEF1" ], "parents" : [ 10423937 ], "children" : [ ] }, { "dbId" : 10415121, "stId" : "R-BTA-6800235", "displayName" : "SPINT1,2 [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "diagramIds" : [ 46129 ], "parents" : [ ], "children" : [ 10415115, 10415119 ] }, { "dbId" : 10345997, "stId" : "R-BTA-354384", "displayName" : "CRKL [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "G3N016", "standardIdentifier" : "uniprot:G3N016", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10359656 ], "children" : [ ] }, { "dbId" : 10415119, "stId" : "R-BTA-6800233", "displayName" : "SPINT2 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Q2KJ54", "standardIdentifier" : "uniprot:Q2KJ54", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SPINT2" ], "parents" : [ 10415121 ], "children" : [ ] }, { "dbId" : 179856, "stId" : "R-ALL-179856", "displayName" : "PI(4,5)P2 [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46196 ], "identifier" : "58456", "standardIdentifier" : "chebi:58456", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10376717, "stId" : "R-BTA-917720", "displayName" : "USP8 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46237 ], "identifier" : "Q0IIM6", "standardIdentifier" : "uniprot:Q0IIM6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "USP8" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10415115, "stId" : "R-BTA-6800232", "displayName" : "SPINT1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46132 ], "identifier" : "Q2KJJ7", "standardIdentifier" : "uniprot:Q2KJJ7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SPINT1" ], "parents" : [ 10415121 ], "children" : [ ] }, { "dbId" : 10415110, "stId" : "R-BTA-8849220", "displayName" : "HPN heterodimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46128 ], "parents" : [ ], "children" : [ 10415106, 10415108 ] }, { "dbId" : 10415108, "stId" : "R-BTA-8849219", "displayName" : "HPN [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A1L5C6", "standardIdentifier" : "uniprot:A1L5C6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HPN" ], "parents" : [ 10415110 ], "children" : [ ] }, { "dbId" : 10415106, "stId" : "R-BTA-6800195", "displayName" : "HPN [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A1L5C6", "standardIdentifier" : "uniprot:A1L5C6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HPN" ], "parents" : [ 10415110 ], "children" : [ ] }, { "dbId" : 10390530, "stId" : "R-BTA-1169488", "displayName" : "SHC1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46172 ], "identifier" : "Q0IIE2", "standardIdentifier" : "uniprot:Q0IIE2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SHC1" ], "parents" : [ 10420405 ], "children" : [ ] }, { "dbId" : 10388482, "stId" : "R-BTA-8851953", "displayName" : "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46194 ], "parents" : [ ], "children" : [ 10388480, 10347547 ] }, { "dbId" : 10388480, "stId" : "R-BTA-8851943", "displayName" : "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "diagramIds" : [ 46191 ], "parents" : [ 10422332, 10423933, 10388482 ], "children" : [ 10388476, 10388478 ] }, { "dbId" : 10416702, "stId" : "R-BTA-9735965", "displayName" : "HGF:MET dimer:TKIs [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46143 ], "parents" : [ ], "children" : [ 9735962, 10416681 ] }, { "dbId" : 10422332, "stId" : "R-BTA-8865998", "displayName" : "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46202 ], "parents" : [ ], "children" : [ 10388480, 10345025 ] }, { "dbId" : 10346033, "stId" : "R-BTA-109783", "displayName" : "p21 RAS:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46160 ], "parents" : [ ], "children" : [ 10346031, 29438 ] }, { "dbId" : 29356, "stId" : "R-ALL-29356", "displayName" : "H2O [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46145, 46235 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10388019, "stId" : "R-BTA-2214304", "displayName" : "Collagen fibres [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "parents" : [ 10423601 ], "children" : [ 10388017, 10388009, 10388011, 10388013, 10388015 ] }, { "dbId" : 10388017, "stId" : "R-BTA-2214301", "displayName" : "Collagen type XXVII fibre [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388019 ], "children" : [ 10377987 ] }, { "dbId" : 10388015, "stId" : "R-BTA-2214303", "displayName" : "Collagen type XI fibre [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388019 ], "children" : [ 10377985 ] }, { "dbId" : 10346031, "stId" : "R-BTA-9649715", "displayName" : "mature p21 RAS [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "parents" : [ 10347614, 10346033 ], "children" : [ 10346019, 10346026, 10346013 ] }, { "dbId" : 10388013, "stId" : "R-BTA-2214302", "displayName" : "Collagen type V fibre [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388019 ], "children" : [ 10360017 ] }, { "dbId" : 10388011, "stId" : "R-BTA-2214307", "displayName" : "Collagen type III fibre [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388019 ], "children" : [ 10359912 ] }, { "dbId" : 10416681, "stId" : "R-BTA-6806956", "displayName" : "HGF:MET dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46138 ], "parents" : [ 10416702 ], "children" : [ 10415130 ] }, { "dbId" : 10346026, "stId" : "R-BTA-9647912", "displayName" : "S-Farn-Me-2xPalmS HRAS [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "G3MXH2", "standardIdentifier" : "uniprot:G3MXH2", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10346031 ], "children" : [ ] }, { "dbId" : 10388009, "stId" : "R-BTA-2214299", "displayName" : "Collagen type II fibre [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388019 ], "children" : [ 10355016 ] }, { "dbId" : 10415143, "stId" : "R-BTA-6800311", "displayName" : "HGFAC dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46131 ], "parents" : [ ], "children" : [ 10415139, 10415141 ] }, { "dbId" : 29370, "stId" : "R-ALL-29370", "displayName" : "ADP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46240, 46177, 46210, 46279, 46199, 46216, 46220, 46141, 46190 ], "identifier" : "456216", "standardIdentifier" : "chebi:456216", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10415141, "stId" : "R-BTA-6800283", "displayName" : "HGFAC [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "E1BCW0", "standardIdentifier" : "uniprot:E1BCW0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HGFAC" ], "parents" : [ 10415143 ], "children" : [ ] }, { "dbId" : 29372, "stId" : "R-ALL-29372", "displayName" : "Pi [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46146 ], "identifier" : "43474", "standardIdentifier" : "chebi:43474", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10415139, "stId" : "R-BTA-1641473", "displayName" : "HGFAC [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "E1BCW0", "standardIdentifier" : "uniprot:E1BCW0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HGFAC" ], "parents" : [ 10415143 ], "children" : [ ] }, { "dbId" : 10346019, "stId" : "R-BTA-9647910", "displayName" : "NRAS [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A5D7R9", "standardIdentifier" : "uniprot:A5D7R9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NRAS" ], "parents" : [ 10346031 ], "children" : [ ] }, { "dbId" : 10347614, "stId" : "R-BTA-109796", "displayName" : "p21 RAS:GDP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46157 ], "parents" : [ ], "children" : [ 29420, 10346031 ] }, { "dbId" : 10345561, "stId" : "R-BTA-2980677", "displayName" : "CRK [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "E1BQ32", "standardIdentifier" : "uniprot:E1BQ32", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CRK" ], "parents" : [ 10359656 ], "children" : [ ] }, { "dbId" : 10333273, "stId" : "R-BTA-939188", "displayName" : "UBC [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P0CH28", "standardIdentifier" : "uniprot:P0CH28", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 10333291 ], "children" : [ ] }, { "dbId" : 9669718, "stId" : "R-ALL-9669718", "displayName" : "cabozantinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "5887", "standardIdentifier" : "iuphar.ligand:5887", "chebiIdentifier" : "chebi:72317", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10423898, "stId" : "R-BTA-8875433", "displayName" : "MET:Ub-LRIG1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46234 ], "parents" : [ 10423909 ], "children" : [ 10423896, 10361641 ] }, { "dbId" : 10423896, "stId" : "R-BTA-8875434", "displayName" : "Ub-LRIG1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MZV0", "standardIdentifier" : "uniprot:F1MZV0", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423898 ], "children" : [ ] }, { "dbId" : 10416724, "stId" : "R-BTA-6807023", "displayName" : "PTPN1,PTPN2 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "diagramIds" : [ 46151 ], "parents" : [ ], "children" : [ 10416722, 10357438 ] }, { "dbId" : 10333265, "stId" : "R-BTA-939203", "displayName" : "UBA52 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P63048", "standardIdentifier" : "uniprot:P63048", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBA52" ], "parents" : [ 10333291 ], "children" : [ ] }, { "dbId" : 10423891, "stId" : "R-BTA-8875375", "displayName" : "MET:LRIG1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46232 ], "parents" : [ ], "children" : [ 10361641, 10347628 ] }, { "dbId" : 10416722, "stId" : "R-BTA-997292", "displayName" : "PTPN2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A5D982", "standardIdentifier" : "uniprot:A5D982", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10416724 ], "children" : [ ] }, { "dbId" : 10333267, "stId" : "R-BTA-939214", "displayName" : "RPS27A [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P62992", "standardIdentifier" : "uniprot:P62992", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RPS27A" ], "parents" : [ 10333291 ], "children" : [ ] }, { "dbId" : 10416720, "stId" : "R-BTA-6807029", "displayName" : "HGF:p-Y,1349,Y1356-MET dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46150 ], "parents" : [ ], "children" : [ 10416718 ] }, { "dbId" : 10416718, "stId" : "R-BTA-6807031", "displayName" : "HGF dimer:p-Y1349,Y1356-MET [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10416720 ], "children" : [ 10367351, 10416716 ] }, { "dbId" : 10359884, "stId" : "R-BTA-2127382", "displayName" : "COL3A1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Q08E14", "standardIdentifier" : "uniprot:Q08E14", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL3A1" ], "parents" : [ 10359910 ], "children" : [ ] }, { "dbId" : 10333263, "stId" : "R-BTA-939205", "displayName" : "UBB [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P0CG53", "standardIdentifier" : "uniprot:P0CG53", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 10333291 ], "children" : [ ] }, { "dbId" : 10416716, "stId" : "R-BTA-6807032", "displayName" : "phospho-p-Y1349,Y1356-MET [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Z4YHD9", "standardIdentifier" : "uniprot:Z4YHD9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10416718 ], "children" : [ ] }, { "dbId" : 9700418, "stId" : "R-ALL-9700418", "displayName" : "foretinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "5679", "standardIdentifier" : "iuphar.ligand:5679", "chebiIdentifier" : "chebi:91418", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10416711, "stId" : "R-BTA-6807016", "displayName" : "HGF:p-Y1234,Y1235,Y1356-MET dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46147 ], "parents" : [ ], "children" : [ 10416709 ] }, { "dbId" : 10416709, "stId" : "R-BTA-6807017", "displayName" : "HGF dimer:p-Y1234,Y1235,Y1356-MET [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10416711 ], "children" : [ 10416707, 10367351 ] }, { "dbId" : 10345025, "stId" : "R-BTA-162563", "displayName" : "PTPN11 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46201 ], "identifier" : "F1N339", "standardIdentifier" : "uniprot:F1N339", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10422332 ], "children" : [ ] }, { "dbId" : 109276, "stId" : "R-ALL-109276", "displayName" : "H2O [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46126 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10416707, "stId" : "R-BTA-6807014", "displayName" : "phospho-p-Y1234,Y1235,Y1356-MET [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Z4YHD9", "standardIdentifier" : "uniprot:Z4YHD9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10416709 ], "children" : [ ] }, { "dbId" : 10423933, "stId" : "R-BTA-8875548", "displayName" : "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46256 ], "parents" : [ 10423961, 10423937, 10423946 ], "children" : [ 10388480, 10359656 ] }, { "dbId" : 10423929, "stId" : "R-BTA-8875527", "displayName" : "HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46253 ], "parents" : [ ], "children" : [ 10423927, 10388474 ] }, { "dbId" : 10423927, "stId" : "R-BTA-8875528", "displayName" : "TNS4:ITGB1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46252 ], "parents" : [ 10423929 ], "children" : [ 10350368, 10423925 ] }, { "dbId" : 10423925, "stId" : "R-BTA-201624", "displayName" : "TNS4 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Q32PJ7", "standardIdentifier" : "uniprot:Q32PJ7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TNS4" ], "parents" : [ 10423927 ], "children" : [ ] }, { "dbId" : 29420, "stId" : "R-ALL-29420", "displayName" : "GDP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46264, 46159 ], "identifier" : "58189", "standardIdentifier" : "chebi:58189", "referenceType" : "ReferenceMolecule", "parents" : [ 10356208, 10347614 ], "children" : [ ] }, { "dbId" : 10423919, "stId" : "R-BTA-8875512", "displayName" : "HGF:p-4Y-MET dimer:TNS3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46250 ], "parents" : [ ], "children" : [ 10388474, 10423917 ] }, { "dbId" : 10359919, "stId" : "R-BTA-2127371", "displayName" : "COL5A1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "G3MZI7", "standardIdentifier" : "uniprot:G3MZI7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL5A1" ], "parents" : [ 10360011, 10359978 ], "children" : [ ] }, { "dbId" : 10347628, "stId" : "R-BTA-197745", "displayName" : "LRIG1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46231 ], "identifier" : "F1MZV0", "standardIdentifier" : "uniprot:F1MZV0", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423891 ], "children" : [ ] }, { "dbId" : 10423917, "stId" : "R-BTA-8875524", "displayName" : "TNS3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46249 ], "identifier" : "A0A3Q1LWU4", "standardIdentifier" : "uniprot:A0A3Q1LWU4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TNS3" ], "parents" : [ 10423919 ], "children" : [ ] }, { "dbId" : 10359912, "stId" : "R-BTA-1474212", "displayName" : "Collagen type III fibril [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388011 ], "children" : [ 10359910 ] }, { "dbId" : 10333291, "stId" : "R-BTA-113595", "displayName" : "Ub [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "diagramIds" : [ 46228, 46236 ], "parents" : [ ], "children" : [ 10333263, 10333273, 10333265, 10333267 ] }, { "dbId" : 10359910, "stId" : "R-BTA-2127436", "displayName" : "Tropocollagen type III [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10359912 ], "children" : [ 10359884 ] }, { "dbId" : 10423911, "stId" : "R-BTA-8875489", "displayName" : "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46247 ], "parents" : [ ], "children" : [ 10423909, 10347748 ] }, { "dbId" : 10423909, "stId" : "R-BTA-8875497", "displayName" : "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "diagramIds" : [ 46245 ], "parents" : [ 10423911 ], "children" : [ 10423905, 10423898 ] }, { "dbId" : 10359395, "stId" : "R-BTA-539044", "displayName" : "STAT3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46275 ], "identifier" : "F1MX38", "standardIdentifier" : "uniprot:F1MX38", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "STAT3" ], "parents" : [ 10423978 ], "children" : [ ] }, { "dbId" : 29438, "stId" : "R-ALL-29438", "displayName" : "GTP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46262, 46158 ], "identifier" : "37565", "standardIdentifier" : "chebi:37565", "referenceType" : "ReferenceMolecule", "parents" : [ 10423969, 10421057, 10356135, 10346033 ], "children" : [ ] }, { "dbId" : 10423905, "stId" : "R-BTA-8875481", "displayName" : "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46243 ], "parents" : [ 10423909 ], "children" : [ 10347778, 10423806 ] }, { "dbId" : 10356127, "stId" : "R-BTA-354118", "displayName" : "RAP1A [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P62833", "standardIdentifier" : "uniprot:P62833", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10356133 ], "children" : [ ] }, { "dbId" : 10337695, "stId" : "R-BTA-74789", "displayName" : "PIK3R1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P23727", "standardIdentifier" : "uniprot:P23727", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PIK3R1" ], "parents" : [ 10347547 ], "children" : [ ] }, { "dbId" : 10337685, "stId" : "R-BTA-64847", "displayName" : "SOS1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46164 ], "identifier" : "F1N7C3", "standardIdentifier" : "uniprot:F1N7C3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SOS1" ], "parents" : [ 10404601, 10337687 ], "children" : [ ] }, { "dbId" : 10337687, "stId" : "R-BTA-109797", "displayName" : "GRB2-1:SOS1 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46153 ], "parents" : [ 10404603, 10404595 ], "children" : [ 10337685, 10337681 ] }, { "dbId" : 10337681, "stId" : "R-BTA-74686", "displayName" : "GRB2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46185 ], "identifier" : "Q3T0F9", "standardIdentifier" : "uniprot:Q3T0F9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "GRB2" ], "parents" : [ 10388476, 10337687, 10347876, 10420421, 10423781 ], "children" : [ ] }, { "dbId" : 9734068, "stId" : "R-ALL-9734068", "displayName" : "onartuzumab [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "8966", "standardIdentifier" : "iuphar.ligand:8966", "parents" : [ 9734118 ], "children" : [ ] }, { "dbId" : 9734076, "stId" : "R-ALL-9734076", "displayName" : "SAIT301 [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "C119619", "standardIdentifier" : "ncit:C119619", "parents" : [ 9734118 ], "children" : [ ] }, { "dbId" : 10423733, "stId" : "R-BTA-8876353", "displayName" : "HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "diagramIds" : [ 46225 ], "parents" : [ ], "children" : [ 10423729, 10423731 ] }, { "dbId" : 10356146, "stId" : "R-BTA-1810408", "displayName" : "phospho-MyrG-p-Y419-SRC [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46212 ], "identifier" : "E1BIM8", "standardIdentifier" : "uniprot:E1BIM8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SRC" ], "parents" : [ 10423619, 10423613, 10423624 ], "children" : [ ] }, { "dbId" : 10423731, "stId" : "R-BTA-8876350", "displayName" : "HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423733 ], "children" : [ 10347714, 10388474 ] }, { "dbId" : 10339761, "stId" : "R-BTA-179795", "displayName" : "GAB1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46182 ], "identifier" : "A6QLU3", "standardIdentifier" : "uniprot:A6QLU3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "GAB1" ], "parents" : [ 10420417, 10420421 ], "children" : [ ] }, { "dbId" : 10423729, "stId" : "R-BTA-8876358", "displayName" : "HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423733 ], "children" : [ 10347876, 10388474 ] }, { "dbId" : 10423727, "stId" : "R-BTA-8876356", "displayName" : "CBL:GRB2,CBL [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "diagramIds" : [ 46224 ], "parents" : [ ], "children" : [ 10347876, 10347714 ] }, { "dbId" : 10423725, "stId" : "R-BTA-8874682", "displayName" : "HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "diagramIds" : [ 46223 ], "parents" : [ ], "children" : [ 10388474, 10423723 ] }, { "dbId" : 10423723, "stId" : "R-BTA-8874694", "displayName" : "HGF:p-Y1003,4Y-MET dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423785, 10423725 ], "children" : [ 10423721 ] }, { "dbId" : 10337705, "stId" : "R-BTA-74787", "displayName" : "PIK3CA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P32871", "standardIdentifier" : "uniprot:P32871", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PIK3CA" ], "parents" : [ 10347547 ], "children" : [ ] }, { "dbId" : 10423721, "stId" : "R-BTA-8874678", "displayName" : "HGF dimer:p-Y1003,4Y-MET [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423723 ], "children" : [ 10367351, 10423719 ] }, { "dbId" : 10423719, "stId" : "R-BTA-8874689", "displayName" : "phospho-p-Y1003,4Y-MET [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Z4YHD9", "standardIdentifier" : "uniprot:Z4YHD9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423721 ], "children" : [ ] }, { "dbId" : 10356135, "stId" : "R-BTA-354126", "displayName" : "RAP1:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46263 ], "parents" : [ ], "children" : [ 29438, 10356133 ] }, { "dbId" : 10356133, "stId" : "R-BTA-377600", "displayName" : "RAP1 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "parents" : [ 10356208, 10356135 ], "children" : [ 10356131, 10356127 ] }, { "dbId" : 10356131, "stId" : "R-BTA-377590", "displayName" : "RAP1B [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P61223", "standardIdentifier" : "uniprot:P61223", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10356133 ], "children" : [ ] }, { "dbId" : 10355659, "stId" : "R-BTA-114561", "displayName" : "ITGA2:ITGB1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423599 ], "children" : [ 10350368, 10355657 ] }, { "dbId" : 10355657, "stId" : "R-BTA-57562", "displayName" : "ITGA2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MBA3", "standardIdentifier" : "uniprot:F1MBA3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ITGA2" ], "parents" : [ 10355659 ], "children" : [ ] }, { "dbId" : 9734092, "stId" : "R-ALL-9734092", "displayName" : "emibetuzumab [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "7748", "standardIdentifier" : "iuphar.ligand:7748", "parents" : [ 9734118 ], "children" : [ ] }, { "dbId" : 10356165, "stId" : "R-BTA-354068", "displayName" : "phospho-p-Y397-PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MAA1", "standardIdentifier" : "uniprot:A0A3Q1MAA1", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423594 ], "children" : [ ] }, { "dbId" : 10388478, "stId" : "R-BTA-8851941", "displayName" : "HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10388480 ], "children" : [ 10347497, 10388474 ] }, { "dbId" : 10423806, "stId" : "R-BTA-8876375", "displayName" : "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "diagramIds" : [ 46229 ], "parents" : [ 10423905 ], "children" : [ 10423796, 10423804 ] }, { "dbId" : 10388476, "stId" : "R-BTA-8851942", "displayName" : "HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10388480 ], "children" : [ 10337681, 10347497, 10388474 ] }, { "dbId" : 10423804, "stId" : "R-BTA-8876374", "displayName" : "HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423806 ], "children" : [ 10423779, 10423802 ] }, { "dbId" : 10388474, "stId" : "R-BTA-6806977", "displayName" : "HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46142 ], "parents" : [ 10423783, 10423729, 10423731, 10423725, 10423929, 10423919, 10420417, 10420421, 10423617, 10423592, 10423611, 10423594, 10423978, 10420405, 10420381, 10420395, 10404593, 10404603, 10404601, 10388478, 10388476 ], "children" : [ 10388472 ] }, { "dbId" : 10423802, "stId" : "R-BTA-8875348", "displayName" : "HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423804 ], "children" : [ 10423800 ] }, { "dbId" : 10388472, "stId" : "R-BTA-6806975", "displayName" : "HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10388474 ], "children" : [ 10367351, 10388470 ] }, { "dbId" : 10423800, "stId" : "R-BTA-8875349", "displayName" : "HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423802 ], "children" : [ 10423798, 10367351 ] }, { "dbId" : 10388470, "stId" : "R-BTA-6806973", "displayName" : "phospho-p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Z4YHD9", "standardIdentifier" : "uniprot:Z4YHD9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10388472 ], "children" : [ ] }, { "dbId" : 10423798, "stId" : "R-BTA-8875180", "displayName" : "phospho-MonoUb-K,p-Y1003,4Y-MET [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Z4YHD9", "standardIdentifier" : "uniprot:Z4YHD9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423800 ], "children" : [ ] }, { "dbId" : 10423796, "stId" : "R-BTA-8876376", "displayName" : "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423806 ], "children" : [ 10423794, 10423781 ] }, { "dbId" : 10423794, "stId" : "R-BTA-8875347", "displayName" : "HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423796 ], "children" : [ 10423792 ] }, { "dbId" : 10356208, "stId" : "R-BTA-354074", "displayName" : "RAP1:GDP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46261 ], "parents" : [ ], "children" : [ 29420, 10356133 ] }, { "dbId" : 10423792, "stId" : "R-BTA-8875345", "displayName" : "HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423794 ], "children" : [ 10367351, 10423790 ] }, { "dbId" : 10423790, "stId" : "R-BTA-8875181", "displayName" : "phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "Z4YHD9", "standardIdentifier" : "uniprot:Z4YHD9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423792 ], "children" : [ ] }, { "dbId" : 9734118, "stId" : "R-ALL-9734118", "displayName" : "Anti-MET MAbs [extracellular region]", "schemaClass" : "CandidateSet", "speciesId" : 0, "diagramIds" : [ 46282 ], "parents" : [ 10415132 ], "children" : [ 9734123, 9734092, 9734068, 9734076 ] }, { "dbId" : 10347497, "stId" : "R-BTA-180344", "displayName" : "phospho-GAB1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A6QLU3", "standardIdentifier" : "uniprot:A6QLU3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "GAB1" ], "parents" : [ 10388478, 10388476 ], "children" : [ ] }, { "dbId" : 10423787, "stId" : "R-BTA-8876355", "displayName" : "HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "diagramIds" : [ 46227 ], "parents" : [ ], "children" : [ 10423783, 10423785 ] }, { "dbId" : 10423785, "stId" : "R-BTA-8876352", "displayName" : "HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423787 ], "children" : [ 10423779, 10423723 ] }, { "dbId" : 10423783, "stId" : "R-BTA-8876357", "displayName" : "HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423787 ], "children" : [ 10423781, 10388474 ] }, { "dbId" : 10423781, "stId" : "R-BTA-8876351", "displayName" : "p-Y-CBL:GRB2 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423796, 10423783 ], "children" : [ 10423779, 10337681 ] }, { "dbId" : 10423779, "stId" : "R-BTA-8875457", "displayName" : "phospho-CBL [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1LN00", "standardIdentifier" : "uniprot:A0A3Q1LN00", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CBL" ], "parents" : [ 10423804, 10423781, 10423785 ], "children" : [ ] }, { "dbId" : 9734123, "stId" : "R-ALL-9734123", "displayName" : "ARGX-111 [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "C113802", "standardIdentifier" : "ncit:C113802", "parents" : [ 9734118 ], "children" : [ ] }, { "dbId" : 9735956, "stId" : "R-ALL-9735956", "displayName" : "SU11274 [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "5057", "standardIdentifier" : "iuphar.ligand:5057", "chebiIdentifier" : "chebi:190974", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 9735957, "stId" : "R-ALL-9735957", "displayName" : "tivantinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7948", "standardIdentifier" : "iuphar.ligand:7948", "chebiIdentifier" : "chebi:91398", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 9735954, "stId" : "R-ALL-9735954", "displayName" : "capmatinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7904", "standardIdentifier" : "iuphar.ligand:7904", "chebiIdentifier" : "chebi:231693", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 9735966, "stId" : "R-ALL-9735966", "displayName" : "SGX-523 [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "5709", "standardIdentifier" : "iuphar.ligand:5709", "chebiIdentifier" : "chebi:90624", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 9735960, "stId" : "R-ALL-9735960", "displayName" : "AMG-337 [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "8913", "standardIdentifier" : "iuphar.ligand:8913", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 9735961, "stId" : "R-ALL-9735961", "displayName" : "BMS-777607 [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7953", "standardIdentifier" : "iuphar.ligand:7953", "chebiIdentifier" : "chebi:91409", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 9735962, "stId" : "R-ALL-9735962", "displayName" : "Anti-MET TKIs [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 0, "diagramIds" : [ 46284 ], "parents" : [ 10416702 ], "children" : [ 9735983, 9735951, 9699597, 9700418, 9735969, 9735961, 9735960, 9735966, 9735987, 9735954, 9669718, 9735991, 9735990, 9735956, 9735985, 9735957, 9735989 ] }, { "dbId" : 9699597, "stId" : "R-ALL-9699597", "displayName" : "crizotinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "4903", "standardIdentifier" : "iuphar.ligand:4903", "chebiIdentifier" : "chebi:64310", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 9735951, "stId" : "R-ALL-9735951", "displayName" : "PHA-665752 [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "5700", "standardIdentifier" : "iuphar.ligand:5700", "chebiIdentifier" : "chebi:90197", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10377987, "stId" : "R-BTA-2193157", "displayName" : "Collagen type XXVII fibril [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388017 ], "children" : [ 10377981 ] }, { "dbId" : 10347776, "stId" : "R-BTA-8867746", "displayName" : "SH3GLs [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "parents" : [ 10347778 ], "children" : [ 10347762, 10347768, 10347774 ] }, { "dbId" : 10377985, "stId" : "R-BTA-2168008", "displayName" : "Collagen type XI fibril [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388015 ], "children" : [ 10377948 ] }, { "dbId" : 10347778, "stId" : "R-BTA-8875480", "displayName" : "CIN85:endophilin [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46242 ], "parents" : [ 10423905 ], "children" : [ 10347776, 10347758 ] }, { "dbId" : 10423615, "stId" : "R-BTA-8874613", "displayName" : "phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MAA1", "standardIdentifier" : "uniprot:A0A3Q1MAA1", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423617 ], "children" : [ ] }, { "dbId" : 10355006, "stId" : "R-BTA-2127364", "displayName" : "5Hyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10421055, "stId" : "R-BTA-2029049", "displayName" : "ARF6 [recycling endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "G3N3N1", "standardIdentifier" : "uniprot:G3N3N1", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10421057 ], "children" : [ ] }, { "dbId" : 9735989, "stId" : "R-ALL-9735989", "displayName" : "OMO-1 [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "10507", "standardIdentifier" : "iuphar.ligand:10507", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 9735990, "stId" : "R-ALL-9735990", "displayName" : "golvatinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7956", "standardIdentifier" : "iuphar.ligand:7956", "chebiIdentifier" : "chebi:177746", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10423613, "stId" : "R-BTA-8874601", "displayName" : "HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46217 ], "parents" : [ ], "children" : [ 10356146, 10423611 ] }, { "dbId" : 10355004, "stId" : "R-BTA-2127399", "displayName" : "GalHyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10352447, "stId" : "R-BTA-6785269", "displayName" : "PTPRJ [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46148 ], "identifier" : "A0A3Q1M6K1", "standardIdentifier" : "uniprot:A0A3Q1M6K1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTPRJ" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 9735991, "stId" : "R-ALL-9735991", "displayName" : "MK-2461 [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7962", "standardIdentifier" : "iuphar.ligand:7962", "chebiIdentifier" : "chebi:230540", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10423611, "stId" : "R-BTA-8874599", "displayName" : "HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423613 ], "children" : [ 10423609, 10388474 ] }, { "dbId" : 10355002, "stId" : "R-BTA-2127413", "displayName" : "3x4Hyp-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 9735985, "stId" : "R-ALL-9735985", "displayName" : "amuvatinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "7932", "standardIdentifier" : "iuphar.ligand:7932", "chebiIdentifier" : "chebi:91389", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10423609, "stId" : "R-BTA-8874600", "displayName" : "phospho-p-Y194,Y397-PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A3Q1MAA1", "standardIdentifier" : "uniprot:A0A3Q1MAA1", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423611 ], "children" : [ ] }, { "dbId" : 10355000, "stId" : "R-BTA-2127366", "displayName" : "3x4Hyp-GlcGalHyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 9735987, "stId" : "R-ALL-9735987", "displayName" : "tepotinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "8293", "standardIdentifier" : "iuphar.ligand:8293", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10354998, "stId" : "R-BTA-2127376", "displayName" : "3x4Hyp-5Hyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10351927, "stId" : "R-BTA-201621", "displayName" : "PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46204 ], "identifier" : "A0A3Q1MAA1", "standardIdentifier" : "uniprot:A0A3Q1MAA1", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423592 ], "children" : [ ] }, { "dbId" : 10354996, "stId" : "R-BTA-2127305", "displayName" : "3x4Hyp-GalHyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10445620, "stId" : "R-BTA-5673001", "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "speciesId" : 48898, "diagramIds" : [ 46290 ] }, { "dbId" : 10423603, "stId" : "R-BTA-8874087", "displayName" : "Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46206 ], "parents" : [ ], "children" : [ 10423601, 10423599 ] }, { "dbId" : 10354994, "stId" : "R-BTA-2127408", "displayName" : "3x4Hyp-3Hyp-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10423601, "stId" : "R-BTA-8874086", "displayName" : "Collagen, laminin, fibronectin [extracellular region]", "schemaClass" : "CandidateSet", "speciesId" : 48898, "parents" : [ 10423603 ], "children" : [ 10388019, 10355062 ] }, { "dbId" : 10354992, "stId" : "R-BTA-2127431", "displayName" : "3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10423599, "stId" : "R-BTA-8874085", "displayName" : "Integrin alpha2beta1,alpha3beta1 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "parents" : [ 10423603 ], "children" : [ 10355032, 10355659 ] }, { "dbId" : 10354989, "stId" : "R-BTA-2127392", "displayName" : "3x4Hyp-3Hyp-5Hyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10354986, "stId" : "R-BTA-2127427", "displayName" : "3x4Hyp-3Hyp-GalHyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 9735969, "stId" : "R-ALL-9735969", "displayName" : "glesatinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "9133", "standardIdentifier" : "iuphar.ligand:9133", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10423594, "stId" : "R-BTA-8874094", "displayName" : "HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46209 ], "parents" : [ 10423624 ], "children" : [ 10356165, 10388474 ] }, { "dbId" : 10361641, "stId" : "R-BTA-419603", "displayName" : "MET [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "diagramIds" : [ 46134 ], "identifier" : "Z4YHD9", "standardIdentifier" : "uniprot:Z4YHD9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10423891, 10423898, 10415132, 10415130 ], "children" : [ ] }, { "dbId" : 10423592, "stId" : "R-BTA-8874088", "displayName" : "HGF:p-4Y-MET dimer:PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46205 ], "parents" : [ ], "children" : [ 10351927, 10388474 ] }, { "dbId" : 113592, "stId" : "R-ALL-113592", "displayName" : "ATP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 46208, 46197, 46278, 46215, 46219, 46140, 46189, 46175, 46239 ], "identifier" : "30616", "standardIdentifier" : "chebi:30616", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 9735983, "stId" : "R-ALL-9735983", "displayName" : "savolitinib [cytosol]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "9918", "standardIdentifier" : "iuphar.ligand:9918", "chebiIdentifier" : "chebi:231369", "parents" : [ 9735962 ], "children" : [ ] }, { "dbId" : 10350368, "stId" : "R-BTA-57596", "displayName" : "ITGB1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "A0A140T8D2", "standardIdentifier" : "uniprot:A0A140T8D2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ITGB1" ], "parents" : [ 10423927, 10355032, 10355659 ], "children" : [ ] }, { "dbId" : 10355032, "stId" : "R-BTA-204444", "displayName" : "Integrin alpha3beta1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423599 ], "children" : [ 10350368, 10355030 ] }, { "dbId" : 10355030, "stId" : "R-BTA-204441", "displayName" : "ITGA3(33-1051) [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MMS9", "standardIdentifier" : "uniprot:F1MMS9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10355032 ], "children" : [ ] }, { "dbId" : 10355016, "stId" : "R-BTA-1474209", "displayName" : "Collagen type II fibril [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10388009 ], "children" : [ 10355014 ] }, { "dbId" : 10423624, "stId" : "R-BTA-8874097", "displayName" : "HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46213 ], "parents" : [ ], "children" : [ 10356146, 10423594 ] }, { "dbId" : 10355014, "stId" : "R-BTA-2127377", "displayName" : "Tropocollagen type II [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10355016 ], "children" : [ 10355012 ] }, { "dbId" : 10355012, "stId" : "R-BTA-2127295", "displayName" : "Collagen alpha-1(II) chains [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "parents" : [ 10377948, 10355014 ], "children" : [ 10355008, 10354992, 10355010, 10354994, 10354996, 10354998, 10355000, 10355002, 10354986, 10354989, 10355004, 10355006 ] }, { "dbId" : 10423619, "stId" : "R-BTA-8874611", "displayName" : "HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46221 ], "parents" : [ ], "children" : [ 10423617, 10356146 ] }, { "dbId" : 10355010, "stId" : "R-BTA-2127330", "displayName" : "GlcGalHyl-COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10423617, "stId" : "R-BTA-8874609", "displayName" : "HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423619 ], "children" : [ 10388474, 10423615 ] }, { "dbId" : 10355008, "stId" : "R-BTA-2127337", "displayName" : "COL2A1(182-1241) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "P02459", "standardIdentifier" : "uniprot:P02459", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "COL2A1" ], "parents" : [ 10355012 ], "children" : [ ] }, { "dbId" : 10421057, "stId" : "R-BTA-2193115", "displayName" : "ARF6:GTP [recycling endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46269 ], "parents" : [ 10423961 ], "children" : [ 29438, 10421055 ] }, { "dbId" : 10355062, "stId" : "R-BTA-2327729", "displayName" : "Fibronectin matrix [extracellular region]", "schemaClass" : "Polymer", "speciesId" : 48898, "parents" : [ 10423601 ], "children" : [ 10352832 ] }, { "dbId" : 10367351, "stId" : "R-BTA-141763", "displayName" : "HGF dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48898, "diagramIds" : [ 46127 ], "parents" : [ 10416709, 10416718, 10423792, 10423800, 10423721, 10415130, 10388472 ], "children" : [ 10367347, 10367349 ] }, { "dbId" : 10367349, "stId" : "R-BTA-56497", "displayName" : "HGF [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MZD6", "standardIdentifier" : "uniprot:F1MZD6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HGF" ], "parents" : [ 10367351 ], "children" : [ ] }, { "dbId" : 10367347, "stId" : "R-BTA-141767", "displayName" : "HGF [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1MZD6", "standardIdentifier" : "uniprot:F1MZD6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HGF" ], "parents" : [ 10367351 ], "children" : [ ] }, { "dbId" : 10359656, "stId" : "R-BTA-381945", "displayName" : "CRK, CRKL [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48898, "diagramIds" : [ 46255 ], "parents" : [ 10423933 ], "children" : [ 10345561, 10345997 ] }, { "dbId" : 10374503, "stId" : "R-BTA-1012970", "displayName" : "DOCK7 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48898, "identifier" : "F1N3L7", "standardIdentifier" : "uniprot:F1N3L7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "DOCK7" ], "parents" : [ 10423944 ], "children" : [ ] }, { "dbId" : 10347876, "stId" : "R-BTA-182910", "displayName" : "CBL:GRB2 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48898, "parents" : [ 10423727, 10423729 ], "children" : [ 10347714, 10337681 ] } ], "edges" : [ { "dbId" : 10415134, "stId" : "R-BTA-6800298", "displayName" : "HGF dimer binds MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10415128, 10415146 ], "following" : [ 10416683 ], "inputs" : [ 10367351, 10361641 ], "outputs" : [ 10415130 ], "efs" : [ ], "inhibitors" : [ 10415132 ], "diagramIds" : [ 46133 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420383, "stId" : "R-BTA-8851804", "displayName" : "Activated MET recruits GRB2-1:SOS1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "following" : [ 10420387 ], "inputs" : [ 10337687, 10388474 ], "outputs" : [ 10404603 ], "efs" : [ ], "inhibitors" : [ 10420381 ], "diagramIds" : [ 46152 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423903, "stId" : "R-BTA-8875451", "displayName" : "MET phosphorylates CBL", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423735 ], "following" : [ 10423809 ], "inputs" : [ 10423733, 113592 ], "outputs" : [ 29370, 10423787 ], "catalysts" : [ 10423733 ], "efs" : [ ], "diagramIds" : [ 46238 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423900, "stId" : "R-BTA-8875443", "displayName" : "USP8 deubiquitinates LRIG1", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 29356, 10423898 ], "outputs" : [ 10423891, 10333291 ], "catalysts" : [ 10376717 ], "efs" : [ ], "diagramIds" : [ 46233 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10415128, "stId" : "R-BTA-6800200", "displayName" : "HPN heterodimer cleaves pro-HGF to form HGF dimer", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10415134 ], "inputs" : [ 109276, 10415126 ], "outputs" : [ 10367351 ], "catalysts" : [ 10415110 ], "efs" : [ ], "inhibitors" : [ 10415121 ], "diagramIds" : [ 46124 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10416727, "stId" : "R-BTA-6807027", "displayName" : "PTPN1 and PTPN2 dephosphorylate MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "inputs" : [ 29356, 10388474 ], "outputs" : [ 10416720, 29372 ], "catalysts" : [ 10416724 ], "efs" : [ ], "diagramIds" : [ 46149 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423893, "stId" : "R-BTA-8875374", "displayName" : "MET binds LRIG1", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10361641, 10347628 ], "outputs" : [ 10423891 ], "efs" : [ ], "diagramIds" : [ 46230 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420430, "stId" : "R-BTA-8851954", "displayName" : "Phosphorylated GAB1 recruits PI3K to MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420428 ], "following" : [ 10420455 ], "inputs" : [ 10388480, 10347547 ], "outputs" : [ 10388482 ], "efs" : [ ], "diagramIds" : [ 46192 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423629, "stId" : "R-BTA-8874083", "displayName" : "p-Y397-PTK2 binds SRC", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423597 ], "following" : [ 10423627 ], "inputs" : [ 10356146, 10423594 ], "outputs" : [ 10423624 ], "efs" : [ ], "diagramIds" : [ 46211 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423948, "stId" : "R-BTA-8875576", "displayName" : "CRK,CRKL recruits RAC1 GEF to activated MET", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 10423935 ], "inputs" : [ 10423944, 10423933 ], "outputs" : [ 10423946 ], "efs" : [ ], "diagramIds" : [ 46265 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420428, "stId" : "R-BTA-8851933", "displayName" : "MET phosphorylates GAB1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420419, 10420423 ], "following" : [ 10422334, 10420430, 10423935 ], "inputs" : [ 113592, 10420425 ], "outputs" : [ 10388480, 29370 ], "catalysts" : [ 10420425 ], "efs" : [ ], "diagramIds" : [ 46187 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423627, "stId" : "R-BTA-8874082", "displayName" : "MET phosphorylates PTK2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423629 ], "following" : [ 10423622 ], "inputs" : [ 113592, 10423624 ], "outputs" : [ 29370, 10423613 ], "catalysts" : [ 10423624 ], "efs" : [ ], "diagramIds" : [ 46214 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10416714, "stId" : "R-BTA-6807008", "displayName" : "PTPRJ dephosphorylates MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "inputs" : [ 29356, 10388474 ], "outputs" : [ 29372, 10416711 ], "catalysts" : [ 10352447 ], "efs" : [ ], "diagramIds" : [ 46144 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420423, "stId" : "R-BTA-8851919", "displayName" : "Activated MET binds GAB1 and GRB2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "following" : [ 10420428 ], "inputs" : [ 10337681, 10339761, 10388474 ], "outputs" : [ 10420421 ], "efs" : [ ], "diagramIds" : [ 46184 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423622, "stId" : "R-BTA-8874080", "displayName" : "SRC phosphorylates PTK2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423627 ], "inputs" : [ 113592, 10423613 ], "outputs" : [ 10423619, 29370 ], "catalysts" : [ 10423613 ], "efs" : [ ], "diagramIds" : [ 46218 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423942, "stId" : "R-BTA-8875568", "displayName" : "RAPGEF1 activates RAP1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423939 ], "inputs" : [ 29438, 10356208 ], "outputs" : [ 29420, 10356135 ], "catalysts" : [ 10423937 ], "efs" : [ ], "diagramIds" : [ 46260 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423939, "stId" : "R-BTA-8875558", "displayName" : "RAPGEF1 binds CRK,CRKL", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423935 ], "following" : [ 10423942 ], "inputs" : [ 10346003, 10423933 ], "outputs" : [ 10423937 ], "efs" : [ ], "diagramIds" : [ 46257 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420419, "stId" : "R-BTA-8851908", "displayName" : "Activated MET binds GAB1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "following" : [ 10420428 ], "inputs" : [ 10339761, 10388474 ], "outputs" : [ 10420417 ], "efs" : [ ], "diagramIds" : [ 46181 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10416704, "stId" : "R-BTA-6806974", "displayName" : "MET dimers autophosphorylate", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416683 ], "following" : [ 10416714, 10416727, 10423735, 10420400, 10420389, 10423931, 10423921, 10420423, 10420419, 10423605, 10423980, 10420407, 10420383, 10420397 ], "inputs" : [ 113592, 10416681 ], "outputs" : [ 29370, 10388474 ], "catalysts" : [ 10416681 ], "efs" : [ ], "inhibitors" : [ 10416702 ], "diagramIds" : [ 46139 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423809, "stId" : "R-BTA-8875183", "displayName" : "CBL monoubiquitinates activated MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423903 ], "following" : [ 10423907 ], "inputs" : [ 10333291, 10423787 ], "outputs" : [ 10423806 ], "catalysts" : [ 10423787 ], "efs" : [ ], "diagramIds" : [ 46226 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420415, "stId" : "R-BTA-8851900", "displayName" : "SHC1-2 bound to MET recruits GRB2:SOS1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420410 ], "following" : [ 10420413 ], "inputs" : [ 10404593, 10337687 ], "outputs" : [ 10404595 ], "efs" : [ ], "diagramIds" : [ 46178 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423935, "stId" : "R-BTA-8875540", "displayName" : "GAB1 recruits CRK,CRKL to MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420428 ], "following" : [ 10423976, 10423939, 10423948 ], "inputs" : [ 10388480, 10359656 ], "outputs" : [ 10423933 ], "efs" : [ ], "diagramIds" : [ 46254 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10422334, "stId" : "R-BTA-8865994", "displayName" : "GAB1 binds PTPN11", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420428 ], "inputs" : [ 10388480, 10345025 ], "outputs" : [ 10422332 ], "efs" : [ ], "diagramIds" : [ 46200 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420413, "stId" : "R-BTA-8851899", "displayName" : "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420415 ], "inputs" : [ 29438, 10347614 ], "outputs" : [ 29420, 10346033 ], "catalysts" : [ 10404595 ], "efs" : [ ], "diagramIds" : [ 46180 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423931, "stId" : "R-BTA-8875531", "displayName" : "MET binds TNS4", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "inputs" : [ 10423927, 10388474 ], "outputs" : [ 10423929 ], "efs" : [ ], "diagramIds" : [ 46251 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420410, "stId" : "R-BTA-8851890", "displayName" : "MET phosphorylates SHC1-2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420407 ], "following" : [ 10420415 ], "inputs" : [ 10420405, 113592 ], "outputs" : [ 10404593, 29370 ], "catalysts" : [ 10420405 ], "efs" : [ ], "diagramIds" : [ 46174 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420407, "stId" : "R-BTA-8851888", "displayName" : "MET binds SHC1-2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "following" : [ 10420410 ], "inputs" : [ 10390530, 10388474 ], "outputs" : [ 10420405 ], "efs" : [ ], "diagramIds" : [ 46171 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423735, "stId" : "R-BTA-8874685", "displayName" : "CBL binds MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "following" : [ 10423903 ], "inputs" : [ 10423725, 10423727 ], "outputs" : [ 10423733 ], "efs" : [ ], "diagramIds" : [ 46222 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423605, "stId" : "R-BTA-8874079", "displayName" : "PTK2 binds activated MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "following" : [ 10423597 ], "inputs" : [ 10351927, 10388474 ], "outputs" : [ 10423592 ], "efs" : [ ], "activators" : [ 10423603 ], "diagramIds" : [ 46203 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420403, "stId" : "R-BTA-8851877", "displayName" : "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420397 ], "inputs" : [ 29438, 10347614 ], "outputs" : [ 29420, 10346033 ], "catalysts" : [ 10404601 ], "efs" : [ ], "diagramIds" : [ 46170 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423921, "stId" : "R-BTA-8875523", "displayName" : "MET binds TNS3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "inputs" : [ 10388474, 10423917 ], "outputs" : [ 10423919 ], "efs" : [ ], "diagramIds" : [ 46248 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420400, "stId" : "R-BTA-8851866", "displayName" : "MET binds RANBP10", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "inputs" : [ 10420393, 10388474 ], "outputs" : [ 10420395 ], "efs" : [ ], "diagramIds" : [ 46168 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423983, "stId" : "R-BTA-8875817", "displayName" : "MET phosphorylates STAT3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423980 ], "inputs" : [ 113592, 10423978 ], "outputs" : [ 29370, 10374681, 10388474 ], "catalysts" : [ 10423978 ], "efs" : [ ], "diagramIds" : [ 46277 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420397, "stId" : "R-BTA-8851859", "displayName" : "Activated MET binds RANBP9 and SOS1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "following" : [ 10420403 ], "inputs" : [ 10404599, 10337685, 10388474 ], "outputs" : [ 10404601 ], "efs" : [ ], "inhibitors" : [ 10420395 ], "diagramIds" : [ 46163 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423597, "stId" : "R-BTA-8874078", "displayName" : "PTK2 autophosphorylates", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423605 ], "following" : [ 10423629 ], "inputs" : [ 113592, 10423592 ], "outputs" : [ 29370, 10423594 ], "catalysts" : [ 10423592 ], "efs" : [ ], "diagramIds" : [ 46207 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10435821, "stId" : "R-BTA-9734070", "displayName" : "Anti-MET recombinant therapeutic antibodies bind MET", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10361641, 9734118 ], "outputs" : [ 10415132 ], "efs" : [ ], "diagramIds" : [ 46281 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423980, "stId" : "R-BTA-8875816", "displayName" : "STAT3 binds activated MET receptor", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "following" : [ 10423983 ], "inputs" : [ 10359395, 10388474 ], "outputs" : [ 10423978 ], "efs" : [ ], "diagramIds" : [ 46274 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10415146, "stId" : "R-BTA-6800299", "displayName" : "HGFAC cleaves pro-HGF to form HGF dimer", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10415134 ], "inputs" : [ 109276, 10415126 ], "outputs" : [ 10367351 ], "catalysts" : [ 10415143 ], "efs" : [ ], "inhibitors" : [ 10415115 ], "diagramIds" : [ 46130 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10416683, "stId" : "R-BTA-6806957", "displayName" : "MET receptor dimerizes", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10415134 ], "following" : [ 10416704 ], "inputs" : [ 10415130 ], "outputs" : [ 10416681 ], "efs" : [ ], "diagramIds" : [ 46137 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423913, "stId" : "R-BTA-8875490", "displayName" : "EPS15 and HGS bind ubiquitinated MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423907 ], "inputs" : [ 10423909, 10347748 ], "outputs" : [ 10423911 ], "efs" : [ ], "diagramIds" : [ 46244 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423976, "stId" : "R-BTA-8875661", "displayName" : "GGA3 associates with activated MET receptor", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 10423935 ], "following" : [ 10423971 ], "inputs" : [ 10421057, 10423974, 10423933 ], "outputs" : [ 10423961 ], "efs" : [ ], "diagramIds" : [ 46268 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420455, "stId" : "R-BTA-8852019", "displayName" : "MET bound PI3K generates PIP3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420430 ], "inputs" : [ 113592, 179856 ], "outputs" : [ 179838, 29370 ], "catalysts" : [ 10388482 ], "efs" : [ ], "diagramIds" : [ 46195 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420389, "stId" : "R-BTA-8851842", "displayName" : "MUC20 binds MET and inhibits GRB2 binding", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10416704 ], "inputs" : [ 10388474, 10420379 ], "outputs" : [ 10420381 ], "efs" : [ ], "diagramIds" : [ 46161 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10420387, "stId" : "R-BTA-8851827", "displayName" : "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10420383 ], "inputs" : [ 29438, 10347614 ], "outputs" : [ 10346033, 29420 ], "catalysts" : [ 10404603 ], "efs" : [ ], "diagramIds" : [ 46156 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423907, "stId" : "R-BTA-8875482", "displayName" : "CBL recruits CIN85:endophilin to ubiquitinated MET", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10423809 ], "following" : [ 10423913 ], "inputs" : [ 10347778, 10423806 ], "outputs" : [ 10423905 ], "efs" : [ ], "diagramIds" : [ 46241 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10423971, "stId" : "R-BTA-8875659", "displayName" : "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 10423976 ], "inputs" : [ 10423961 ], "outputs" : [ 10388474 ], "efs" : [ ], "activators" : [ 10423969 ], "diagramIds" : [ 46272 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10435872, "stId" : "R-BTA-9735946", "displayName" : "Anti-MET small tyrosine kinase inhibitors bind MET", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 9735962, 10416681 ], "outputs" : [ 10416702 ], "efs" : [ ], "diagramIds" : [ 46283 ], "entityFunctionalStatus" : [ ] } ], "subpathways" : [ { "dbId" : 10445886, "stId" : "R-BTA-8875791", "displayName" : "MET activates STAT3", "events" : [ 10423983, 10423980 ] }, { "dbId" : 10446178, "stId" : "R-BTA-9734091", "displayName" : "Drug-mediated inhibition of MET activation", "events" : [ 10435821, 10435872 ] }, { "dbId" : 10445884, "stId" : "R-BTA-8875656", "displayName" : "MET receptor recycling", "events" : [ 10423976, 10423971 ] }, { "dbId" : 10445870, "stId" : "R-BTA-8875878", "displayName" : "MET promotes cell motility", "events" : [ 10423597, 10423629, 10423627, 10423622, 10423605, 10423935, 10423948, 10423942, 10423939, 10423931, 10423921 ] }, { "dbId" : 10445806, "stId" : "R-BTA-8851805", "displayName" : "MET activates RAS signaling", "events" : [ 10420383, 10420415, 10420397, 10420413, 10420410, 10420407, 10420389, 10420387, 10420403, 10420400 ] }, { "dbId" : 10445882, "stId" : "R-BTA-8875555", "displayName" : "MET activates RAP1 and RAC1", "events" : [ 10423935, 10423948, 10423942, 10423939 ] }, { "dbId" : 10445742, "stId" : "R-BTA-6807004", "displayName" : "Negative regulation of MET activity", "events" : [ 10423903, 10423900, 10416714, 10423913, 10423735, 10416727, 10423893, 10423907, 10435821, 10435872, 10423809 ] }, { "dbId" : 10445726, "stId" : "R-BTA-6806942", "displayName" : "MET Receptor Activation", "events" : [ 10415134, 10415146, 10416683, 10415128, 10416704 ] }, { "dbId" : 10445858, "stId" : "R-BTA-8865999", "displayName" : "MET activates PTPN11", "events" : [ 10422334 ] }, { "dbId" : 10445868, "stId" : "R-BTA-8874081", "displayName" : "MET activates PTK2 signaling", "events" : [ 10423597, 10423629, 10423627, 10423622, 10423605 ] }, { "dbId" : 10445880, "stId" : "R-BTA-8875513", "displayName" : "MET interacts with TNS proteins", "events" : [ 10423931, 10423921 ] }, { "dbId" : 10445808, "stId" : "R-BTA-8851907", "displayName" : "MET activates PI3K/AKT signaling", "events" : [ 10420430, 10420428, 10420423, 10420455, 10420419 ] } ] }