{
  "dbId" : 10445128,
  "stId" : "R-BTA-1679131",
  "speciesName" : "Bos taurus",
  "nodes" : [ {
    "dbId" : 10381214,
    "stId" : "R-BTA-1678929",
    "displayName" : "TLR7 [Golgi membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MK24",
    "standardIdentifier" : "uniprot:A0A3Q1MK24",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR7" ],
    "parents" : [ 10381216 ],
    "children" : [ ]
  }, {
    "dbId" : 10381151,
    "stId" : "R-BTA-1679027",
    "displayName" : "TLR7 [endolysosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MK24",
    "standardIdentifier" : "uniprot:A0A3Q1MK24",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR7" ],
    "parents" : [ 10381153 ],
    "children" : [ ]
  }, {
    "dbId" : 10381212,
    "stId" : "R-BTA-1678955",
    "displayName" : "TLR3 [Golgi membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3S5ZPK8",
    "standardIdentifier" : "uniprot:A0A3S5ZPK8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR3" ],
    "parents" : [ 10381222 ],
    "children" : [ ]
  }, {
    "dbId" : 10381149,
    "stId" : "R-BTA-1678956",
    "displayName" : "C-ter-TLR9 dimer [endolysosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103357 ],
    "parents" : [ ],
    "children" : [ 10381147 ]
  }, {
    "dbId" : 10381147,
    "stId" : "R-BTA-1678982",
    "displayName" : "TLR9 [endolysosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A5H631",
    "standardIdentifier" : "uniprot:A5H631",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR9" ],
    "parents" : [ 10381149 ],
    "children" : [ ]
  }, {
    "dbId" : 10381208,
    "stId" : "R-BTA-1679076",
    "displayName" : "ATP-bound Gp96 dimer:CNPY3:TLR7/8/9 [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103343 ],
    "parents" : [ ],
    "children" : [ 10381200, 10381204, 211579, 10381196 ]
  }, {
    "dbId" : 10381145,
    "stId" : "R-BTA-1679073",
    "displayName" : "FL-TLR9 dimer [endolysosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103354 ],
    "parents" : [ ],
    "children" : [ 10381143 ]
  }, {
    "dbId" : 10381206,
    "stId" : "R-BTA-1678941",
    "displayName" : "Apo-GP96 dimer [endoplasmic reticulum lumen]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103342 ],
    "parents" : [ ],
    "children" : [ 10381204 ]
  }, {
    "dbId" : 10381143,
    "stId" : "R-BTA-167979",
    "displayName" : "TLR9 [endolysosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A5H631",
    "standardIdentifier" : "uniprot:A5H631",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR9" ],
    "parents" : [ 10381145 ],
    "children" : [ ]
  }, {
    "dbId" : 10381204,
    "stId" : "R-BTA-981545",
    "displayName" : "HSP90B1 [endoplasmic reticulum lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q95M18",
    "standardIdentifier" : "uniprot:Q95M18",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10381206, 10381208 ],
    "children" : [ ]
  }, {
    "dbId" : 10381141,
    "stId" : "R-BTA-188168",
    "displayName" : "FL-TLR7 dimer [endolysosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103355 ],
    "parents" : [ ],
    "children" : [ 10381139 ]
  }, {
    "dbId" : 10381139,
    "stId" : "R-BTA-168005",
    "displayName" : "TLR7 [endolysosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MK24",
    "standardIdentifier" : "uniprot:A0A3Q1MK24",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR7" ],
    "parents" : [ 10381141 ],
    "children" : [ ]
  }, {
    "dbId" : 10381200,
    "stId" : "R-BTA-1678932",
    "displayName" : "CNPY3 [endoplasmic reticulum lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 103339 ],
    "identifier" : "Q0P5N1",
    "standardIdentifier" : "uniprot:Q0P5N1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CNPY3" ],
    "parents" : [ 10381208 ],
    "children" : [ ]
  }, {
    "dbId" : 10381196,
    "stId" : "R-BTA-1679009",
    "displayName" : "TLR7/8/9 [endoplasmic reticulum membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 103340 ],
    "parents" : [ 10381208 ],
    "children" : [ 10381176, 10381180 ]
  }, {
    "dbId" : 211606,
    "stId" : "R-ALL-211606",
    "displayName" : "ADP [endoplasmic reticulum membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 103346 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10381192,
    "stId" : "R-BTA-1678926",
    "displayName" : "intracellular TLR:UNC93B1 [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103350 ],
    "parents" : [ ],
    "children" : [ 10381186, 10381190 ]
  }, {
    "dbId" : 10381190,
    "stId" : "R-BTA-1678930",
    "displayName" : "UNC93B1 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 103349 ],
    "identifier" : "E1BBH4",
    "standardIdentifier" : "uniprot:E1BBH4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UNC93B1" ],
    "parents" : [ 10381192 ],
    "children" : [ ]
  }, {
    "dbId" : 10381186,
    "stId" : "R-BTA-1679054",
    "displayName" : "intracellular TLR3/7/8/9 [endoplasmic reticulum membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 103348 ],
    "parents" : [ 10381192 ],
    "children" : [ 10381184, 10381174 ]
  }, {
    "dbId" : 10381184,
    "stId" : "R-BTA-1679066",
    "displayName" : "folded FL-TLR7/8/9  [endoplasmic reticulum membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 103345 ],
    "parents" : [ 10381186 ],
    "children" : [ 10381178, 10381182 ]
  }, {
    "dbId" : 10381182,
    "stId" : "R-BTA-1678978",
    "displayName" : "FL-TLR9 dimer [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10381184 ],
    "children" : [ 10381180 ]
  }, {
    "dbId" : 10381180,
    "stId" : "R-BTA-1678961",
    "displayName" : "TLR9 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A5H631",
    "standardIdentifier" : "uniprot:A5H631",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR9" ],
    "parents" : [ 10381196, 10381182 ],
    "children" : [ ]
  }, {
    "dbId" : 10381178,
    "stId" : "R-BTA-1678995",
    "displayName" : "FL-TLR7 dimer [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10381184 ],
    "children" : [ 10381176 ]
  }, {
    "dbId" : 10381176,
    "stId" : "R-BTA-1678943",
    "displayName" : "TLR7 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MK24",
    "standardIdentifier" : "uniprot:A0A3Q1MK24",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR7" ],
    "parents" : [ 10381196, 10381178 ],
    "children" : [ ]
  }, {
    "dbId" : 10381174,
    "stId" : "R-BTA-1679057",
    "displayName" : "TLR3 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 103368 ],
    "identifier" : "A0A3S5ZPK8",
    "standardIdentifier" : "uniprot:A0A3S5ZPK8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR3" ],
    "parents" : [ 10381186 ],
    "children" : [ ]
  }, {
    "dbId" : 10381238,
    "stId" : "R-BTA-4127476",
    "displayName" : "CTSS-like proteins [endolysosome lumen]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48898,
    "diagramIds" : [ 103362 ],
    "parents" : [ ],
    "children" : [ 10381161, 10381236 ]
  }, {
    "dbId" : 10381236,
    "stId" : "R-BTA-4127477",
    "displayName" : "CTSL2 [endolysosome lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P25975",
    "standardIdentifier" : "uniprot:P25975",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10381238 ],
    "children" : [ ]
  }, {
    "dbId" : 10381234,
    "stId" : "R-BTA-1679007",
    "displayName" : "N-ter TLR9 dimer [endolysosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103361 ],
    "parents" : [ ],
    "children" : [ 10381232 ]
  }, {
    "dbId" : 10381232,
    "stId" : "R-BTA-1679032",
    "displayName" : "TLR9 [endolysosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A5H631",
    "standardIdentifier" : "uniprot:A5H631",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR9" ],
    "parents" : [ 10381234 ],
    "children" : [ ]
  }, {
    "dbId" : 10381167,
    "stId" : "R-BTA-1678911",
    "displayName" : "Legumain/Cathepsins [endolysosome lumen]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 103358 ],
    "parents" : [ ],
    "children" : [ 10381163, 10381165 ]
  }, {
    "dbId" : 10381165,
    "stId" : "R-BTA-8942384",
    "displayName" : "LGMN [endolysosome lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A140T8D4",
    "standardIdentifier" : "uniprot:A0A140T8D4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LGMN" ],
    "parents" : [ 10381167 ],
    "children" : [ ]
  }, {
    "dbId" : 10381226,
    "stId" : "R-BTA-1679067",
    "displayName" : "intracellular TLR:UNC93B1 [Golgi membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103352 ],
    "parents" : [ ],
    "children" : [ 10381222, 10381224 ]
  }, {
    "dbId" : 10381163,
    "stId" : "R-BTA-1678971",
    "displayName" : "Cathepsins B, K, L, S [endolysosome lumen]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10381167 ],
    "children" : [ 10381157, 10381159, 10381161 ]
  }, {
    "dbId" : 10381224,
    "stId" : "R-BTA-1679064",
    "displayName" : "UNC93B1 [Golgi membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BBH4",
    "standardIdentifier" : "uniprot:E1BBH4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UNC93B1" ],
    "parents" : [ 10381226 ],
    "children" : [ ]
  }, {
    "dbId" : 10381161,
    "stId" : "R-BTA-1679012",
    "displayName" : "CTSS [endolysosome lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P25326",
    "standardIdentifier" : "uniprot:P25326",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CTSS" ],
    "parents" : [ 10381238, 10381163 ],
    "children" : [ ]
  }, {
    "dbId" : 211579,
    "stId" : "R-ALL-211579",
    "displayName" : "ATP [endoplasmic reticulum membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 103341 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10381208 ],
    "children" : [ ]
  }, {
    "dbId" : 10381222,
    "stId" : "R-BTA-1679038",
    "displayName" : "TLR3/7/8/9 [Golgi membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10381226 ],
    "children" : [ 10381216, 10381220, 10381212 ]
  }, {
    "dbId" : 10381159,
    "stId" : "R-BTA-1678985",
    "displayName" : "CTSK [endolysosome lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q5E968",
    "standardIdentifier" : "uniprot:Q5E968",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CTSK" ],
    "parents" : [ 10381163 ],
    "children" : [ ]
  }, {
    "dbId" : 10381220,
    "stId" : "R-BTA-1679083",
    "displayName" : "FL-TLR9:FL-TLR9 [Golgi membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10381222 ],
    "children" : [ 10381218 ]
  }, {
    "dbId" : 10381157,
    "stId" : "R-BTA-1679058",
    "displayName" : "CTSB [endolysosome lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P07688",
    "standardIdentifier" : "uniprot:P07688",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CTSB" ],
    "parents" : [ 10381163 ],
    "children" : [ ]
  }, {
    "dbId" : 10381218,
    "stId" : "R-BTA-1678997",
    "displayName" : "TLR9 [Golgi membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A5H631",
    "standardIdentifier" : "uniprot:A5H631",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TLR9" ],
    "parents" : [ 10381220 ],
    "children" : [ ]
  }, {
    "dbId" : 9631150,
    "stId" : "R-ALL-9631150",
    "displayName" : "H+ [endolysosome lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 103359 ],
    "identifier" : "15378",
    "standardIdentifier" : "chebi:15378",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10381216,
    "stId" : "R-BTA-1679085",
    "displayName" : "FL-TLR7 dimer [Golgi membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10381222 ],
    "children" : [ 10381214 ]
  }, {
    "dbId" : 10381153,
    "stId" : "R-BTA-1678924",
    "displayName" : "C-ter TLR7 dimer [endolysosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 103356 ],
    "parents" : [ ],
    "children" : [ 10381151 ]
  } ],
  "edges" : [ {
    "dbId" : 10381230,
    "stId" : "R-BTA-1678944",
    "displayName" : "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex ",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10381210 ],
    "following" : [ 10381194 ],
    "inputs" : [ 10381208 ],
    "outputs" : [ 10381184, 10381200, 10381206, 211606 ],
    "efs" : [ ],
    "diagramIds" : [ 103344 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10381210,
    "stId" : "R-BTA-1678923",
    "displayName" : "TLR folding by chaperones GP96 and CNPY3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10381230 ],
    "inputs" : [ 10381200, 10381206, 211579, 10381196 ],
    "outputs" : [ 10381208 ],
    "efs" : [ ],
    "diagramIds" : [ 103338 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10381194,
    "stId" : "R-BTA-1678921",
    "displayName" : "Full-length TLR3/7/8/9 binds to UNC93B1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10381230 ],
    "following" : [ 10381243 ],
    "inputs" : [ 10381186, 10381190 ],
    "outputs" : [ 10381192 ],
    "efs" : [ ],
    "diagramIds" : [ 103347 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10381243,
    "stId" : "R-BTA-1678998",
    "displayName" : "Endosomal TLRs pass through the Golgi",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10381194 ],
    "inputs" : [ 10381192 ],
    "outputs" : [ 10381226 ],
    "efs" : [ ],
    "diagramIds" : [ 103351 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10381241,
    "stId" : "R-BTA-1678981",
    "displayName" : "TLR9 processing at neutral pH",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10381145 ],
    "outputs" : [ 10381234 ],
    "catalysts" : [ 10381238 ],
    "efs" : [ ],
    "diagramIds" : [ 103360 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10381170,
    "stId" : "R-BTA-1678920",
    "displayName" : "TLR processing at low pH",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10381141, 10381145 ],
    "outputs" : [ 10381153, 10381149 ],
    "catalysts" : [ 10381167 ],
    "efs" : [ ],
    "activators" : [ 9631150 ],
    "diagramIds" : [ 103353 ],
    "entityFunctionalStatus" : [ ]
  } ]
}