{
  "dbId" : 10444188,
  "stId" : "R-BTA-376176",
  "speciesName" : "Bos taurus",
  "nodes" : [ {
    "dbId" : 10429981,
    "stId" : "R-BTA-9010869",
    "displayName" : "SLIT2:Dystroglycan [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123681 ],
    "parents" : [ ],
    "children" : [ 10353606, 10429979 ]
  }, {
    "dbId" : 10429979,
    "stId" : "R-BTA-2328140",
    "displayName" : "Dystroglycan [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123680 ],
    "parents" : [ 10429981 ],
    "children" : [ 10429975, 10429977 ]
  }, {
    "dbId" : 10333273,
    "stId" : "R-BTA-939188",
    "displayName" : "UBC [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P0CH28",
    "standardIdentifier" : "uniprot:P0CH28",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBC" ],
    "parents" : [ 10333291 ],
    "children" : [ ]
  }, {
    "dbId" : 10429977,
    "stId" : "R-BTA-2328154",
    "displayName" : "DAG1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MDA4",
    "standardIdentifier" : "uniprot:A0A3Q1MDA4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DAG1" ],
    "parents" : [ 10429979 ],
    "children" : [ ]
  }, {
    "dbId" : 10429975,
    "stId" : "R-BTA-2328152",
    "displayName" : "DAG1 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MDA4",
    "standardIdentifier" : "uniprot:A0A3Q1MDA4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DAG1" ],
    "parents" : [ 10429979 ],
    "children" : [ ]
  }, {
    "dbId" : 10409877,
    "stId" : "R-BTA-5696962",
    "displayName" : "USP33 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 123674 ],
    "identifier" : "A6QNM7",
    "standardIdentifier" : "uniprot:A6QNM7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10429971,
    "stId" : "R-BTA-9010818",
    "displayName" : "SLIT2,(SLIT3):Keratan sulfate [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123678 ],
    "parents" : [ ],
    "children" : [ 10429969, 2299699 ]
  }, {
    "dbId" : 10333265,
    "stId" : "R-BTA-939203",
    "displayName" : "UBA52 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P63048",
    "standardIdentifier" : "uniprot:P63048",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBA52" ],
    "parents" : [ 10333291 ],
    "children" : [ ]
  }, {
    "dbId" : 10429969,
    "stId" : "R-BTA-9010822",
    "displayName" : "SLIT2,(SLIT3) [extracellular region]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48898,
    "diagramIds" : [ 123677 ],
    "parents" : [ 10429971 ],
    "children" : [ 10353606, 10429967 ]
  }, {
    "dbId" : 10333267,
    "stId" : "R-BTA-939214",
    "displayName" : "RPS27A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P62992",
    "standardIdentifier" : "uniprot:P62992",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RPS27A" ],
    "parents" : [ 10333291 ],
    "children" : [ ]
  }, {
    "dbId" : 381898,
    "stId" : "R-ALL-381898",
    "displayName" : "Heparan sulfate N-acetyl-alpha-D-glucosaminide [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "70974",
    "standardIdentifier" : "chebi:70974",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10363699 ],
    "children" : [ ]
  }, {
    "dbId" : 2299699,
    "stId" : "R-ALL-2299699",
    "displayName" : "Keratan sulfate [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 123676 ],
    "identifier" : "60924",
    "standardIdentifier" : "chebi:60924",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10429971, 10430630 ],
    "children" : [ ]
  }, {
    "dbId" : 10363790,
    "stId" : "R-BTA-376027",
    "displayName" : "SLIT2:p-Y1073-ROBO1:ABL [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123660 ],
    "parents" : [ ],
    "children" : [ 10363788, 10357180 ]
  }, {
    "dbId" : 10429967,
    "stId" : "R-BTA-204357",
    "displayName" : "SLIT3 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 123729 ],
    "identifier" : "F1MMM6",
    "standardIdentifier" : "uniprot:F1MMM6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SLIT3" ],
    "parents" : [ 10429969 ],
    "children" : [ ]
  }, {
    "dbId" : 10363788,
    "stId" : "R-BTA-428499",
    "displayName" : "p-Y1073-ROBO1:SLIT2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10363790 ],
    "children" : [ 10353606, 10363786 ]
  }, {
    "dbId" : 10333263,
    "stId" : "R-BTA-939205",
    "displayName" : "UBB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P0CG53",
    "standardIdentifier" : "uniprot:P0CG53",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBB" ],
    "parents" : [ 10333291 ],
    "children" : [ ]
  }, {
    "dbId" : 10363786,
    "stId" : "R-BTA-375979",
    "displayName" : "phospho-ROBO1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1N739",
    "standardIdentifier" : "uniprot:F1N739",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ROBO1" ],
    "parents" : [ 10363788 ],
    "children" : [ ]
  }, {
    "dbId" : 10444554,
    "stId" : "R-BTA-5627117",
    "displayName" : "RHO GTPases Activate ROCKs",
    "schemaClass" : "Pathway",
    "speciesId" : 48898,
    "diagramIds" : [ 123705 ]
  }, {
    "dbId" : 10353608,
    "stId" : "R-BTA-390371",
    "displayName" : "ROBO1:SLIT2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123654 ],
    "parents" : [ 10357182, 10429321 ],
    "children" : [ 10353602, 10353606 ]
  }, {
    "dbId" : 10429321,
    "stId" : "R-BTA-8985583",
    "displayName" : "SLIT2:ROBO1:MYO9B [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123664 ],
    "parents" : [ ],
    "children" : [ 10353608, 10385341 ]
  }, {
    "dbId" : 10429385,
    "stId" : "R-BTA-8986095",
    "displayName" : "ROBO1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 123672 ],
    "identifier" : "F1N739",
    "standardIdentifier" : "uniprot:F1N739",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ROBO1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10444680,
    "stId" : "R-BTA-5627123",
    "displayName" : "RHO GTPases activate PAKs",
    "schemaClass" : "Pathway",
    "speciesId" : 48898,
    "diagramIds" : [ 123701 ]
  }, {
    "dbId" : 10353606,
    "stId" : "R-BTA-375997",
    "displayName" : "SLIT2 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 123648, 123652 ],
    "identifier" : "F1MLJ7",
    "standardIdentifier" : "uniprot:F1MLJ7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SLIT2" ],
    "parents" : [ 10363788, 10429969, 10429981, 10353608, 10363701 ],
    "children" : [ ]
  }, {
    "dbId" : 10353602,
    "stId" : "R-BTA-204361",
    "displayName" : "ROBO1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 123683, 123653 ],
    "identifier" : "F1N739",
    "standardIdentifier" : "uniprot:F1N739",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ROBO1" ],
    "parents" : [ 10430630, 10353608 ],
    "children" : [ ]
  }, {
    "dbId" : 10357182,
    "stId" : "R-BTA-428873",
    "displayName" : "SLIT2:ROBO1:ABL [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123657 ],
    "parents" : [ ],
    "children" : [ 10353608, 10357180 ]
  }, {
    "dbId" : 10357180,
    "stId" : "R-BTA-376002",
    "displayName" : "ABL [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 123656 ],
    "parents" : [ 10363790, 10357182 ],
    "children" : [ 10357174, 10357178 ]
  }, {
    "dbId" : 10385341,
    "stId" : "R-BTA-2029011",
    "displayName" : "MYO9B [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 123663 ],
    "identifier" : "E1BNV7",
    "standardIdentifier" : "uniprot:E1BNV7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10429321 ],
    "children" : [ ]
  }, {
    "dbId" : 10357178,
    "stId" : "R-BTA-375998",
    "displayName" : "ABL2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MWH8",
    "standardIdentifier" : "uniprot:F1MWH8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10357180 ],
    "children" : [ ]
  }, {
    "dbId" : 10341432,
    "stId" : "R-BTA-5665993",
    "displayName" : "RHOA:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123666 ],
    "parents" : [ ],
    "children" : [ 29438, 10341428 ]
  }, {
    "dbId" : 10357174,
    "stId" : "R-BTA-375987",
    "displayName" : "ABL1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1LI98",
    "standardIdentifier" : "uniprot:A0A3Q1LI98",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10357180 ],
    "children" : [ ]
  }, {
    "dbId" : 10341428,
    "stId" : "R-BTA-194510",
    "displayName" : "RHOA [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P61585",
    "standardIdentifier" : "uniprot:P61585",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10341430, 10341432 ],
    "children" : [ ]
  }, {
    "dbId" : 10341430,
    "stId" : "R-BTA-8964174",
    "displayName" : "RHOA:GDP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123668 ],
    "parents" : [ ],
    "children" : [ 29420, 10341428 ]
  }, {
    "dbId" : 10363701,
    "stId" : "R-BTA-428489",
    "displayName" : "SLIT2,SLIT2 cleavage fragments:GPC1:HSPG [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123650 ],
    "parents" : [ ],
    "children" : [ 10363699, 10353606 ]
  }, {
    "dbId" : 29356,
    "stId" : "R-ALL-29356",
    "displayName" : "H2O [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 123667, 123671 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29420,
    "stId" : "R-ALL-29420",
    "displayName" : "GDP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "58189",
    "standardIdentifier" : "chebi:58189",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10341430 ],
    "children" : [ ]
  }, {
    "dbId" : 10363699,
    "stId" : "R-BTA-428493",
    "displayName" : "GPC1:HSPG [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123649 ],
    "parents" : [ 10363701 ],
    "children" : [ 381898, 10363697 ]
  }, {
    "dbId" : 10363697,
    "stId" : "R-BTA-425952",
    "displayName" : "GPC1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1LZ29",
    "standardIdentifier" : "uniprot:A0A3Q1LZ29",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GPC1" ],
    "parents" : [ 10363699 ],
    "children" : [ ]
  }, {
    "dbId" : 10333291,
    "stId" : "R-BTA-113595",
    "displayName" : "Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 123673 ],
    "parents" : [ ],
    "children" : [ 10333263, 10333273, 10333265, 10333267 ]
  }, {
    "dbId" : 10430630,
    "stId" : "R-BTA-9014813",
    "displayName" : "ROBO1,ROBO2:Keratan sulfate [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 123684 ],
    "parents" : [ ],
    "children" : [ 10353602, 2299699 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 123659 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 123661 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10444836,
    "stId" : "R-BTA-927802",
    "displayName" : "Nonsense-Mediated Decay (NMD)",
    "schemaClass" : "Pathway",
    "speciesId" : 48898,
    "diagramIds" : [ 123728 ]
  }, {
    "dbId" : 29372,
    "stId" : "R-ALL-29372",
    "displayName" : "Pi [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 123669 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29438,
    "stId" : "R-ALL-29438",
    "displayName" : "GTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "37565",
    "standardIdentifier" : "chebi:37565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10341432 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10429983,
    "stId" : "R-BTA-9010872",
    "displayName" : "SLIT2 binds Dystroglycan",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10353606, 10429979 ],
    "outputs" : [ 10429981 ],
    "efs" : [ ],
    "diagramIds" : [ 123679 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10429326,
    "stId" : "R-BTA-8985594",
    "displayName" : "MYO9B inactivates RHOA",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29356, 10341432 ],
    "outputs" : [ 29372, 10341430 ],
    "catalysts" : [ 10385341 ],
    "efs" : [ ],
    "inhibitors" : [ 10429321 ],
    "diagramIds" : [ 123665 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10429388,
    "stId" : "R-BTA-8986083",
    "displayName" : "USP33 deubiquitinates ROBO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29356, 10429385 ],
    "outputs" : [ 10353602, 10333291 ],
    "catalysts" : [ 10409877 ],
    "efs" : [ ],
    "diagramIds" : [ 123670 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10429323,
    "stId" : "R-BTA-8985591",
    "displayName" : "SLIT2-bound ROBO1 binds MYO9B",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10353610 ],
    "inputs" : [ 10353608, 10385341 ],
    "outputs" : [ 10429321 ],
    "efs" : [ ],
    "diagramIds" : [ 123662 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10430632,
    "stId" : "R-BTA-9014812",
    "displayName" : "ROBOs bind keratan sulfate",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10353602, 2299699 ],
    "outputs" : [ 10430630 ],
    "efs" : [ ],
    "diagramIds" : [ 123682 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10353610,
    "stId" : "R-BTA-204364",
    "displayName" : "ROBO1 binds SLIT2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10357184, 10429323 ],
    "inputs" : [ 10353602, 10353606 ],
    "outputs" : [ 10353608 ],
    "efs" : [ ],
    "diagramIds" : [ 123651 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10363703,
    "stId" : "R-BTA-428518",
    "displayName" : "Glypican-1 (GPC1) binds SLIT2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10363699, 10353606 ],
    "outputs" : [ 10363701 ],
    "efs" : [ ],
    "diagramIds" : [ 123647 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10429973,
    "stId" : "R-BTA-9010815",
    "displayName" : "SLITs bind keratan sulfate",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10429969, 2299699 ],
    "outputs" : [ 10429971 ],
    "efs" : [ ],
    "diagramIds" : [ 123675 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10357184,
    "stId" : "R-BTA-376141",
    "displayName" : "Interaction of ABL with ROBO1:SLIT2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10353610 ],
    "following" : [ 10363793 ],
    "inputs" : [ 10353608, 10357180 ],
    "outputs" : [ 10357182 ],
    "efs" : [ ],
    "diagramIds" : [ 123655 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10363793,
    "stId" : "R-BTA-428888",
    "displayName" : "Phosphorylation of ROBO1 by ABL kinase",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10357184 ],
    "inputs" : [ 113592, 10357182 ],
    "outputs" : [ 29370, 10363790 ],
    "catalysts" : [ 10357182 ],
    "efs" : [ ],
    "diagramIds" : [ 123658 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10445954,
    "stId" : "R-BTA-9010553",
    "displayName" : "Regulation of expression of SLITs and ROBOs",
    "events" : [ 10429983, 10429388 ]
  }, {
    "dbId" : 10444358,
    "stId" : "R-BTA-428890",
    "displayName" : "Role of ABL in ROBO-SLIT signaling",
    "events" : [ 10357184, 10363793 ]
  }, {
    "dbId" : 10445950,
    "stId" : "R-BTA-8985586",
    "displayName" : "SLIT2:ROBO1 increases RHOA activity",
    "events" : [ 10429326, 10429323 ]
  } ]
}