{
  "dbId" : 10444162,
  "stId" : "R-BTA-397795",
  "speciesName" : "Bos taurus",
  "nodes" : [ {
    "dbId" : 10360350,
    "stId" : "R-BTA-425642",
    "displayName" : "PIK3R6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A7MBD5",
    "standardIdentifier" : "uniprot:A7MBD5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3R6" ],
    "parents" : [ 10360352 ],
    "children" : [ ]
  }, {
    "dbId" : 10428702,
    "stId" : "R-BTA-9014575",
    "displayName" : "G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136029 ],
    "parents" : [ 10428704, 10428708 ],
    "children" : [ 10340993, 10428700 ]
  }, {
    "dbId" : 10428700,
    "stId" : "R-BTA-9014578",
    "displayName" : "Active PAK1:ARHGEF6 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136027 ],
    "parents" : [ 10428702 ],
    "children" : [ 10362338, 10360575 ]
  }, {
    "dbId" : 10360346,
    "stId" : "R-BTA-392289",
    "displayName" : "PIK3R5 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BCV1",
    "standardIdentifier" : "uniprot:E1BCV1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3R5" ],
    "parents" : [ 10360352 ],
    "children" : [ ]
  }, {
    "dbId" : 10360342,
    "stId" : "R-BTA-392286",
    "displayName" : "PIK3CG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1M2L5",
    "standardIdentifier" : "uniprot:A0A3Q1M2L5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3CG" ],
    "parents" : [ 10360354 ],
    "children" : [ ]
  }, {
    "dbId" : 10361231,
    "stId" : "R-BTA-398037",
    "displayName" : "G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136012 ],
    "parents" : [ ],
    "children" : [ 10340993, 10361229 ]
  }, {
    "dbId" : 179856,
    "stId" : "R-ALL-179856",
    "displayName" : "PI(4,5)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 136003 ],
    "identifier" : "58456",
    "standardIdentifier" : "chebi:58456",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10361229,
    "stId" : "R-BTA-425749",
    "displayName" : "PLC-beta 1/2/3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 136011 ],
    "parents" : [ 10361231 ],
    "children" : [ 10340646, 374868 ]
  }, {
    "dbId" : 10340993,
    "stId" : "R-BTA-167434",
    "displayName" : "G-protein beta-gamma complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136000 ],
    "parents" : [ 10361231, 10361163, 10428702, 10428662 ],
    "children" : [ 10340991, 10340971 ]
  }, {
    "dbId" : 10347836,
    "stId" : "R-BTA-449545",
    "displayName" : "CDC42 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 136031 ],
    "identifier" : "Q2KJ93",
    "standardIdentifier" : "uniprot:Q2KJ93",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10428708, 10347838 ],
    "children" : [ ]
  }, {
    "dbId" : 10347838,
    "stId" : "R-BTA-182921",
    "displayName" : "CDC42:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136039 ],
    "parents" : [ 10428704 ],
    "children" : [ 29438, 10347836 ]
  }, {
    "dbId" : 9729200,
    "stId" : "R-BTA-9729200",
    "displayName" : "GNG3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P63214",
    "standardIdentifier" : "uniprot:P63214",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG3", "GNGT3" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 10352696,
    "stId" : "R-BTA-202676",
    "displayName" : "PIP3:RhoA [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136009 ],
    "parents" : [ ],
    "children" : [ 179838, 10341428 ]
  }, {
    "dbId" : 10341428,
    "stId" : "R-BTA-194510",
    "displayName" : "RHOA [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 136008 ],
    "identifier" : "P61585",
    "standardIdentifier" : "uniprot:P61585",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10352696 ],
    "children" : [ ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 136004 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 136005 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10428708,
    "stId" : "R-BTA-8964627",
    "displayName" : "G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136032 ],
    "parents" : [ ],
    "children" : [ 10428702, 10347836 ]
  }, {
    "dbId" : 10340646,
    "stId" : "R-BTA-61695",
    "displayName" : "PLCB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1LVV4",
    "standardIdentifier" : "uniprot:A0A3Q1LVV4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10361229 ],
    "children" : [ ]
  }, {
    "dbId" : 10360354,
    "stId" : "R-BTA-392291",
    "displayName" : "PI3K gamma [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 135999 ],
    "parents" : [ 10361163 ],
    "children" : [ 10360352, 10360342 ]
  }, {
    "dbId" : 10360352,
    "stId" : "R-BTA-425644",
    "displayName" : "PI3-kinase gamma, regulatory subunit [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10360354 ],
    "children" : [ 10360346, 10360350 ]
  }, {
    "dbId" : 10428704,
    "stId" : "R-BTA-9014577",
    "displayName" : "G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136034, 136036 ],
    "parents" : [ ],
    "children" : [ 10347838, 10428702 ]
  }, {
    "dbId" : 10340958,
    "stId" : "R-BTA-164329",
    "displayName" : "GNG11 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q5E9F0",
    "standardIdentifier" : "uniprot:Q5E9F0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG11" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 10340954,
    "stId" : "R-BTA-164344",
    "displayName" : "GNG10 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q3SZ98",
    "standardIdentifier" : "uniprot:Q3SZ98",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG10" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 9717212,
    "stId" : "R-BTA-9717212",
    "displayName" : "GNG2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P63212",
    "standardIdentifier" : "uniprot:P63212",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG2" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 10340950,
    "stId" : "R-BTA-167440",
    "displayName" : "GNGT2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P50154",
    "standardIdentifier" : "uniprot:P50154",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNGT2" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 10340946,
    "stId" : "R-BTA-164371",
    "displayName" : "GNG8 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MYW8",
    "standardIdentifier" : "uniprot:F1MYW8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG8" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 374868,
    "stId" : "R-BTA-374868",
    "displayName" : "PLC beta 1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P10894",
    "standardIdentifier" : "uniprot:P10894",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PLCB1" ],
    "parents" : [ 10361229 ],
    "children" : [ ]
  }, {
    "dbId" : 10340942,
    "stId" : "R-BTA-164325",
    "displayName" : "GNG7 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P30671",
    "standardIdentifier" : "uniprot:P30671",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG7" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 10361163,
    "stId" : "R-BTA-392293",
    "displayName" : "G-protein beta-gamma:PI3K gamma [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136001 ],
    "parents" : [ ],
    "children" : [ 10360354, 10340993 ]
  }, {
    "dbId" : 114519,
    "stId" : "R-ALL-114519",
    "displayName" : "DAG [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 136014 ],
    "identifier" : "17815",
    "standardIdentifier" : "chebi:17815",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10340938,
    "stId" : "R-BTA-164383",
    "displayName" : "GNG5 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P63217",
    "standardIdentifier" : "uniprot:P63217",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG5" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 114520,
    "stId" : "R-ALL-114520",
    "displayName" : "I(1,4,5)P3 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 136015 ],
    "identifier" : "203600",
    "standardIdentifier" : "chebi:203600",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10340934,
    "stId" : "R-BTA-164350",
    "displayName" : "GNG4 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A4IFL6",
    "standardIdentifier" : "uniprot:A4IFL6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG4" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 10340989,
    "stId" : "R-BTA-6814416",
    "displayName" : "GNB5 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3S5ZPL0",
    "standardIdentifier" : "uniprot:A0A3S5ZPL0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNB5" ],
    "parents" : [ 10340991 ],
    "children" : [ ]
  }, {
    "dbId" : 10360575,
    "stId" : "R-BTA-162629",
    "displayName" : "PAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 136038, 136026 ],
    "identifier" : "Q08E52",
    "standardIdentifier" : "uniprot:Q08E52",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10428700 ],
    "children" : [ ]
  }, {
    "dbId" : 10340991,
    "stId" : "R-BTA-6814413",
    "displayName" : "G-protein beta subunit [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48898,
    "parents" : [ 10340993 ],
    "children" : [ 10340974, 10340978, 10340982, 10340986, 10340989 ]
  }, {
    "dbId" : 10340986,
    "stId" : "R-BTA-6814417",
    "displayName" : "GNB4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A5PKD6",
    "standardIdentifier" : "uniprot:A5PKD6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNB4" ],
    "parents" : [ 10340991 ],
    "children" : [ ]
  }, {
    "dbId" : 10428662,
    "stId" : "R-BTA-8964249",
    "displayName" : "PIP3:BTK:G-protein beta-gamma complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 136019, 136022 ],
    "parents" : [ ],
    "children" : [ 10340993, 179838, 10387946 ]
  }, {
    "dbId" : 10340982,
    "stId" : "R-BTA-6814414",
    "displayName" : "GNB3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BB14",
    "standardIdentifier" : "uniprot:E1BB14",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNB3" ],
    "parents" : [ 10340991 ],
    "children" : [ ]
  }, {
    "dbId" : 10340978,
    "stId" : "R-BTA-6814421",
    "displayName" : "GNB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P11017",
    "standardIdentifier" : "uniprot:P11017",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNB2" ],
    "parents" : [ 10340991 ],
    "children" : [ ]
  }, {
    "dbId" : 10340974,
    "stId" : "R-BTA-6814412",
    "displayName" : "GNB1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P62871",
    "standardIdentifier" : "uniprot:P62871",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNB1" ],
    "parents" : [ 10340991 ],
    "children" : [ ]
  }, {
    "dbId" : 10340969,
    "stId" : "R-BTA-167428",
    "displayName" : "GNGT1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P02698",
    "standardIdentifier" : "uniprot:P02698",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNGT1" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 10387946,
    "stId" : "R-BTA-197948",
    "displayName" : "BTK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 136017, 136023 ],
    "identifier" : "Q3ZC95",
    "standardIdentifier" : "uniprot:Q3ZC95",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10428662 ],
    "children" : [ ]
  }, {
    "dbId" : 10340971,
    "stId" : "R-BTA-167442",
    "displayName" : "G-protein gamma subunit [plasma membrane]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48898,
    "parents" : [ 10340993 ],
    "children" : [ 9717212, 10340962, 10340946, 10340966, 10340950, 10340934, 10340954, 10340938, 10340969, 9729200, 10340958, 10340942 ]
  }, {
    "dbId" : 10340966,
    "stId" : "R-BTA-164346",
    "displayName" : "GNG13 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1B8Q3",
    "standardIdentifier" : "uniprot:E1B8Q3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG13" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  }, {
    "dbId" : 10362338,
    "stId" : "R-BTA-195017",
    "displayName" : "ARHGEF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 136025 ],
    "identifier" : "E1BIM5",
    "standardIdentifier" : "uniprot:E1BIM5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ARHGEF6" ],
    "parents" : [ 10428700 ],
    "children" : [ ]
  }, {
    "dbId" : 179838,
    "stId" : "R-ALL-179838",
    "displayName" : "PI(3,4,5)P3 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 136018, 136006 ],
    "identifier" : "57836",
    "standardIdentifier" : "chebi:57836",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10428662, 10352696 ],
    "children" : [ ]
  }, {
    "dbId" : 29438,
    "stId" : "R-ALL-29438",
    "displayName" : "GTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "37565",
    "standardIdentifier" : "chebi:37565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10347838 ],
    "children" : [ ]
  }, {
    "dbId" : 10340962,
    "stId" : "R-BTA-164367",
    "displayName" : "GNG12 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "Q28024",
    "standardIdentifier" : "uniprot:Q28024",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GNG12" ],
    "parents" : [ 10340971 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10428664,
    "stId" : "R-BTA-8964241",
    "displayName" : "G beta-gamma complex and PIP3 recruit BTK to membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10428682 ],
    "inputs" : [ 10340993, 179838, 10387946 ],
    "outputs" : [ 10428662 ],
    "efs" : [ ],
    "diagramIds" : [ 136016 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10352698,
    "stId" : "R-BTA-202692",
    "displayName" : "PIP3 binds to RhoA and activates it",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10361168 ],
    "inputs" : [ 179838, 10341428 ],
    "outputs" : [ 10352696 ],
    "efs" : [ ],
    "diagramIds" : [ 136007 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10428692,
    "stId" : "R-BTA-8964317",
    "displayName" : "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10428682 ],
    "inputs" : [ 10428662 ],
    "outputs" : [ 10340993, 179838, 10387946 ],
    "efs" : [ ],
    "diagramIds" : [ 136021 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10361168,
    "stId" : "R-BTA-392300",
    "displayName" : "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10361165 ],
    "following" : [ 10352698 ],
    "inputs" : [ 113592, 179856 ],
    "outputs" : [ 179838, 29370 ],
    "catalysts" : [ 10361163 ],
    "efs" : [ ],
    "diagramIds" : [ 136002 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10361233,
    "stId" : "R-BTA-398040",
    "displayName" : "Gbeta:gamma activation of PLC beta",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10361248 ],
    "inputs" : [ 10340993, 10361229 ],
    "outputs" : [ 10361231 ],
    "efs" : [ ],
    "diagramIds" : [ 136010 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10428719,
    "stId" : "R-BTA-8964634",
    "displayName" : "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10428713 ],
    "following" : [ 10428711 ],
    "inputs" : [ 10428702, 10347836 ],
    "outputs" : [ 10428708 ],
    "efs" : [ ],
    "diagramIds" : [ 136030 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10428717,
    "stId" : "R-BTA-8964619",
    "displayName" : "PAK1 binds ARHGEF6",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10428713 ],
    "inputs" : [ 10362338, 10360575 ],
    "outputs" : [ 10428700 ],
    "efs" : [ ],
    "diagramIds" : [ 136024 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10361165,
    "stId" : "R-BTA-392295",
    "displayName" : "Gbeta:gamma recruits PI3K gamma",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10361168 ],
    "inputs" : [ 10360354, 10340993 ],
    "outputs" : [ 10361163 ],
    "efs" : [ ],
    "diagramIds" : [ 135998 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10428715,
    "stId" : "R-BTA-8964614",
    "displayName" : "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10428711 ],
    "following" : [ 10428706 ],
    "inputs" : [ 10428704 ],
    "outputs" : [ 10428704 ],
    "efs" : [ ],
    "diagramIds" : [ 136035 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10428682,
    "stId" : "R-BTA-8964271",
    "displayName" : "BTK in PIP3:BTK:G beta-gamma complex is activated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10428664 ],
    "following" : [ 10428692 ],
    "inputs" : [ 10428662 ],
    "outputs" : [ 10428662 ],
    "efs" : [ ],
    "diagramIds" : [ 136020 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10428713,
    "stId" : "R-BTA-8964605",
    "displayName" : "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10428717 ],
    "following" : [ 10428719 ],
    "inputs" : [ 10340993, 10428700 ],
    "outputs" : [ 10428702 ],
    "efs" : [ ],
    "diagramIds" : [ 136028 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10428711,
    "stId" : "R-BTA-8964604",
    "displayName" : "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10428719 ],
    "following" : [ 10428715 ],
    "inputs" : [ 10428708 ],
    "outputs" : [ 10428704 ],
    "catalysts" : [ 10428708 ],
    "efs" : [ ],
    "diagramIds" : [ 136033 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10428706,
    "stId" : "R-BTA-8964599",
    "displayName" : "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10428715 ],
    "inputs" : [ 10428704 ],
    "outputs" : [ 10362338, 10340993, 10347838, 10360575 ],
    "efs" : [ ],
    "diagramIds" : [ 136037 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10361248,
    "stId" : "R-BTA-398193",
    "displayName" : "PLC beta-mediated PIP2 hydrolysis",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10361233 ],
    "inputs" : [ 179856 ],
    "outputs" : [ 114520, 114519 ],
    "catalysts" : [ 10361231 ],
    "efs" : [ ],
    "diagramIds" : [ 136013 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10444160,
    "stId" : "R-BTA-392451",
    "displayName" : "G beta:gamma signalling through PI3Kgamma",
    "events" : [ 10361165, 10352698, 10361168 ]
  }, {
    "dbId" : 10444496,
    "stId" : "R-BTA-418217",
    "displayName" : "G beta:gamma signalling through PLC beta",
    "events" : [ 10361248, 10361233 ]
  }, {
    "dbId" : 10445944,
    "stId" : "R-BTA-8964616",
    "displayName" : "G beta:gamma signalling through CDC42",
    "events" : [ 10428719, 10428717, 10428715, 10428713, 10428711, 10428706 ]
  }, {
    "dbId" : 10445942,
    "stId" : "R-BTA-8964315",
    "displayName" : "G beta:gamma signalling through BTK",
    "events" : [ 10428682, 10428664, 10428692 ]
  } ]
}