{ "dbId" : 10444140, "stableId" : "R-BTA-9009391", "displayName" : "Extra-nuclear estrogen signaling", "nodes" : [ { "id" : 110593, "reactomeId" : 10431053, "displayName" : "PalmS-ESRs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 461, "y" : 544 }, "minX" : 420, "maxX" : 506, "minY" : 501, "maxY" : 578, "prop" : { "x" : 420, "y" : 531, "width" : 82, "height" : 27 }, "textPosition" : { "x" : 420, "y" : 534 }, "connectors" : [ { "edgeId" : 110596, "type" : "INPUT", "segments" : [ { "from" : { "x" : 456, "y" : 525 }, "to" : { "x" : 446, "y" : 501 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110589, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 478, "y" : 564 }, "to" : { "x" : 506, "y" : 578 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 486, "y" : 564 }, "b" : { "x" : 478, "y" : 564 }, "c" : { "x" : 482, "y" : 571 }, "type" : "ARROW", "centre" : { "x" : 482, "y" : 571 } } } ] }, { "id" : 110592, "reactomeId" : 76194, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 582, "y" : 545 }, "minX" : 506, "maxX" : 607, "minY" : 526, "maxY" : 578, "prop" : { "x" : 558, "y" : 527, "width" : 48, "height" : 37 }, "textPosition" : { "x" : 564, "y" : 528 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 601, "y" : 532 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 601, "y" : 532 } } }, "connectors" : [ { "edgeId" : 110589, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 555, "y" : 555 }, "to" : { "x" : 506, "y" : 578 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 550, "y" : 562 }, "b" : { "x" : 555, "y" : 555 }, "c" : { "x" : 547, "y" : 554 }, "type" : "ARROW", "centre" : { "x" : 547, "y" : 554 } } } ] }, { "id" : 110720, "reactomeId" : 10445620, "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2585, "y" : 616 }, "minX" : 2515, "maxX" : 2656, "minY" : 586, "maxY" : 646, "prop" : { "x" : 2515, "y" : 586, "width" : 141, "height" : 60 }, "textPosition" : { "x" : 2526, "y" : 594 }, "connectors" : [ ] }, { "id" : 110595, "reactomeId" : 10431071, "displayName" : "ZDHHC7, ZDHHC21", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 392, "y" : 615 }, "minX" : 349, "maxX" : 498, "minY" : 597, "maxY" : 634, "prop" : { "x" : 349, "y" : 597, "width" : 86, "height" : 37 }, "textPosition" : { "x" : 358, "y" : 598 }, "connectors" : [ { "edgeId" : 110589, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 441, "y" : 613 }, "to" : { "x" : 490, "y" : 611 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 494, "y" : 611 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 494, "y" : 611 } } } ] }, { "id" : 110594, "reactomeId" : 10398185, "displayName" : "HSBP1 oligomer", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 580, "y" : 805 }, "minX" : 501, "maxX" : 641, "minY" : 578, "maxY" : 818, "prop" : { "x" : 525, "y" : 792, "width" : 110, "height" : 26 }, "textPosition" : { "x" : 526, "y" : 794 }, "connectors" : [ { "edgeId" : 110602, "type" : "INPUT", "segments" : [ { "from" : { "x" : 556, "y" : 789 }, "to" : { "x" : 501, "y" : 761 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110589, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 583, "y" : 789 }, "to" : { "x" : 641, "y" : 582 } }, { "from" : { "x" : 641, "y" : 582 }, "to" : { "x" : 506, "y" : 578 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 581, "y" : 781 }, "b" : { "x" : 583, "y" : 789 }, "c" : { "x" : 589, "y" : 783 }, "type" : "ARROW", "centre" : { "x" : 589, "y" : 783 } } } ] }, { "id" : 110597, "reactomeId" : 10431061, "displayName" : "CAVs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 385, "y" : 518 }, "minX" : 363, "maxX" : 446, "minY" : 501, "maxY" : 529, "prop" : { "x" : 363, "y" : 507, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 365, "y" : 507 }, "connectors" : [ { "edgeId" : 110596, "type" : "INPUT", "segments" : [ { "from" : { "x" : 413, "y" : 511 }, "to" : { "x" : 446, "y" : 501 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110727, "reactomeId" : 10442766, "displayName" : "Mitotic G1 phase and G1/S transition", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1845, "y" : 1315 }, "minX" : 1784, "maxX" : 1906, "minY" : 1279, "maxY" : 1351, "prop" : { "x" : 1784, "y" : 1279, "width" : 122, "height" : 72 }, "textPosition" : { "x" : 1783, "y" : 1286 }, "connectors" : [ ] }, { "id" : 110726, "reactomeId" : 10340057, "displayName" : "PDPK1:PIP3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2766, "y" : 276 }, "minX" : 2731, "maxX" : 2807, "minY" : 254, "maxY" : 293, "prop" : { "x" : 2731, "y" : 260, "width" : 70, "height" : 33 }, "textPosition" : { "x" : 2740, "y" : 258 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2801, "y" : 260 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2801, "y" : 260 } } }, "connectors" : [ ] }, { "id" : 110598, "reactomeId" : 10431063, "displayName" : "PalmS-ESRs:CAVs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 221, "y" : 490 }, "minX" : 180, "maxX" : 268, "minY" : 466, "maxY" : 509, "prop" : { "x" : 180, "y" : 472, "width" : 82, "height" : 37 }, "textPosition" : { "x" : 184, "y" : 474 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 262, "y" : 472 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 262, "y" : 472 } } }, "connectors" : [ { "edgeId" : 110596, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110599, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110601, "reactomeId" : 10431086, "displayName" : "PalmS-ESRs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 96, "y" : 226 }, "minX" : 50, "maxX" : 199, "minY" : 214, "maxY" : 318, "prop" : { "x" : 50, "y" : 214, "width" : 93, "height" : 24 }, "textPosition" : { "x" : 56, "y" : 215 }, "connectors" : [ { "edgeId" : 110599, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 98, "y" : 244 }, "to" : { "x" : 114, "y" : 318 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 103, "y" : 250 }, "b" : { "x" : 98, "y" : 244 }, "c" : { "x" : 96, "y" : 252 }, "type" : "ARROW", "centre" : { "x" : 96, "y" : 252 } } }, { "edgeId" : 110647, "type" : "INPUT", "segments" : [ { "from" : { "x" : 149, "y" : 229 }, "to" : { "x" : 199, "y" : 234 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110600, "reactomeId" : 10431078, "displayName" : "CAVs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 64, "y" : 309 }, "minX" : 42, "maxX" : 114, "minY" : 298, "maxY" : 320, "prop" : { "x" : 42, "y" : 298, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 44, "y" : 298 }, "connectors" : [ { "edgeId" : 110599, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 92, "y" : 312 }, "to" : { "x" : 114, "y" : 318 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 100, "y" : 310 }, "b" : { "x" : 92, "y" : 312 }, "c" : { "x" : 98, "y" : 318 }, "type" : "ARROW", "centre" : { "x" : 98, "y" : 318 } } } ] }, { "id" : 110603, "reactomeId" : 10388488, "displayName" : "ESRs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 463, "y" : 801 }, "minX" : 435, "maxX" : 501, "minY" : 761, "maxY" : 814, "prop" : { "x" : 435, "y" : 789, "width" : 57, "height" : 25 }, "textPosition" : { "x" : 444, "y" : 791 }, "connectors" : [ { "edgeId" : 110602, "type" : "INPUT", "segments" : [ { "from" : { "x" : 474, "y" : 783 }, "to" : { "x" : 501, "y" : 761 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110605, "reactomeId" : 374146, "displayName" : "ESTG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 91, "y" : 40 }, "minX" : 68, "maxX" : 419, "minY" : 25, "maxY" : 226, "prop" : { "x" : 68, "y" : 26, "width" : 47, "height" : 28 }, "textPosition" : { "x" : 71, "y" : 29 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 110, "y" : 31 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 110, "y" : 31 } } }, "connectors" : [ { "edgeId" : 110604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 118, "y" : 50 }, "to" : { "x" : 419, "y" : 188 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 262, "y" : 113 }, "b" : { "x" : 274, "y" : 125 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 268, "y" : 119 } } } }, { "edgeId" : 110647, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 100, "y" : 57 }, "to" : { "x" : 218, "y" : 226 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 211, "y" : 223 }, "b" : { "x" : 218, "y" : 226 }, "c" : { "x" : 217, "y" : 218 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 217, "y" : 218 } } } ] }, { "id" : 110607, "reactomeId" : 10431101, "displayName" : "ESTG:Me-PalmS-ESR dimers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 480, "y" : 246 }, "minX" : 424, "maxX" : 556, "minY" : 217, "maxY" : 270, "prop" : { "x" : 424, "y" : 223, "width" : 113, "height" : 47 }, "textPosition" : { "x" : 426, "y" : 235 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 537, "y" : 223 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 537, "y" : 223 } } }, "connectors" : [ { "edgeId" : 110604, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110677, "type" : "INPUT", "segments" : [ { "from" : { "x" : 540, "y" : 248 }, "to" : { "x" : 556, "y" : 249 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110606, "reactomeId" : 10431099, "displayName" : "Me-PalmS-ESRs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 345, "y" : 247 }, "minX" : 243, "maxX" : 419, "minY" : 188, "maxY" : 268, "prop" : { "x" : 291, "y" : 226, "width" : 109, "height" : 42 }, "textPosition" : { "x" : 294, "y" : 236 }, "connectors" : [ { "edgeId" : 110604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 371, "y" : 220 }, "to" : { "x" : 419, "y" : 188 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 389, "y" : 198 }, "b" : { "x" : 401, "y" : 210 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 395, "y" : 204 } } } }, { "edgeId" : 110647, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 285, "y" : 239 }, "to" : { "x" : 243, "y" : 233 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 278, "y" : 242 }, "b" : { "x" : 285, "y" : 239 }, "c" : { "x" : 279, "y" : 234 }, "type" : "ARROW", "centre" : { "x" : 279, "y" : 234 } } } ] }, { "id" : 110609, "reactomeId" : 10388494, "displayName" : "ESRs:STRN:ESTG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 834, "y" : 302 }, "minX" : 788, "maxX" : 1108, "minY" : 202, "maxY" : 320, "prop" : { "x" : 788, "y" : 285, "width" : 93, "height" : 35 }, "textPosition" : { "x" : 795, "y" : 285 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 881, "y" : 285 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 881, "y" : 285 } } }, "connectors" : [ { "edgeId" : 110608, "type" : "INPUT", "segments" : [ { "from" : { "x" : 839, "y" : 282 }, "to" : { "x" : 863, "y" : 202 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110612, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 884, "y" : 285 }, "to" : { "x" : 1108, "y" : 205 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 889, "y" : 279 }, "b" : { "x" : 884, "y" : 285 }, "c" : { "x" : 892, "y" : 286 }, "type" : "ARROW", "centre" : { "x" : 892, "y" : 286 } } }, { "edgeId" : 110615, "type" : "INPUT", "segments" : [ { "from" : { "x" : 884, "y" : 305 }, "to" : { "x" : 1060, "y" : 320 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110611, "reactomeId" : 10431125, "displayName" : "ESTG:ESRs:STRN:heterotrimeric G(i) protein", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 984, "y" : 170 }, "minX" : 926, "maxX" : 1048, "minY" : 134, "maxY" : 200, "prop" : { "x" : 926, "y" : 140, "width" : 116, "height" : 60 }, "textPosition" : { "x" : 926, "y" : 151 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1042, "y" : 140 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1042, "y" : 140 } } }, "connectors" : [ { "edgeId" : 110608, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110612, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110610, "reactomeId" : 10359015, "displayName" : "Heterotrimeric G-protein Gi (inactive)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 783, "y" : 167 }, "minX" : 720, "maxX" : 863, "minY" : 141, "maxY" : 202, "prop" : { "x" : 720, "y" : 147, "width" : 127, "height" : 41 }, "textPosition" : { "x" : 726, "y" : 139 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 847, "y" : 147 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 847, "y" : 147 } } }, "connectors" : [ { "edgeId" : 110608, "type" : "INPUT", "segments" : [ { "from" : { "x" : 829, "y" : 191 }, "to" : { "x" : 863, "y" : 202 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110613, "reactomeId" : 10345823, "displayName" : "G-protein alpha (i):GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1222, "y" : 132 }, "minX" : 1108, "maxX" : 1287, "minY" : 107, "maxY" : 325, "prop" : { "x" : 1163, "y" : 113, "width" : 118, "height" : 38 }, "textPosition" : { "x" : 1167, "y" : 116 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1281, "y" : 113 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1281, "y" : 113 } } }, "connectors" : [ { "edgeId" : 110612, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1192, "y" : 154 }, "to" : { "x" : 1108, "y" : 205 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1188, "y" : 161 }, "b" : { "x" : 1192, "y" : 154 }, "c" : { "x" : 1184, "y" : 154 }, "type" : "ARROW", "centre" : { "x" : 1184, "y" : 154 } } }, { "edgeId" : 110615, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1223, "y" : 154 }, "to" : { "x" : 1235, "y" : 325 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1231, "y" : 318 }, "b" : { "x" : 1235, "y" : 325 }, "c" : { "x" : 1239, "y" : 318 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1239, "y" : 318 } } } ] }, { "id" : 110614, "reactomeId" : 10340993, "displayName" : "G-protein beta-gamma complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1155, "y" : 267 }, "minX" : 1095, "maxX" : 1229, "minY" : 205, "maxY" : 329, "prop" : { "x" : 1095, "y" : 249, "width" : 121, "height" : 37 }, "textPosition" : { "x" : 1101, "y" : 251 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1216, "y" : 249 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1216, "y" : 249 } } }, "connectors" : [ { "edgeId" : 110612, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1140, "y" : 246 }, "to" : { "x" : 1108, "y" : 205 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1133, "y" : 243 }, "b" : { "x" : 1140, "y" : 246 }, "c" : { "x" : 1139, "y" : 238 }, "type" : "ARROW", "centre" : { "x" : 1139, "y" : 238 } } }, { "edgeId" : 110615, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1177, "y" : 289 }, "to" : { "x" : 1229, "y" : 329 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1221, "y" : 328 }, "b" : { "x" : 1229, "y" : 329 }, "c" : { "x" : 1226, "y" : 322 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1226, "y" : 322 } } } ] }, { "id" : 110617, "reactomeId" : 10431119, "displayName" : "ESRs:STRN:ESTG:MyrG-SRC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1363, "y" : 138 }, "minX" : 1302, "maxX" : 1472, "minY" : 76, "maxY" : 158, "prop" : { "x" : 1302, "y" : 118, "width" : 123, "height" : 40 }, "textPosition" : { "x" : 1306, "y" : 123 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1425, "y" : 118 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1425, "y" : 118 } } }, "connectors" : [ { "edgeId" : 110615, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110618, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1428, "y" : 132 }, "to" : { "x" : 1448, "y" : 131 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110618, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1394, "y" : 115 }, "to" : { "x" : 1461, "y" : 76 } }, { "from" : { "x" : 1461, "y" : 76 }, "to" : { "x" : 1467, "y" : 114 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1468, "y" : 118 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1468, "y" : 118 } } } ] }, { "id" : 110616, "reactomeId" : 10347488, "displayName" : "MyrG-SRC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1037, "y" : 266 }, "minX" : 997, "maxX" : 1083, "minY" : 241, "maxY" : 320, "prop" : { "x" : 997, "y" : 247, "width" : 80, "height" : 38 }, "textPosition" : { "x" : 1004, "y" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1077, "y" : 247 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1077, "y" : 247 } } }, "connectors" : [ { "edgeId" : 110615, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1045, "y" : 288 }, "to" : { "x" : 1060, "y" : 320 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110619, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1418, "y" : 181 }, "minX" : 1394, "maxX" : 1448, "minY" : 131, "maxY" : 199, "prop" : { "x" : 1394, "y" : 163, "width" : 49, "height" : 36 }, "textPosition" : { "x" : 1403, "y" : 170 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1438, "y" : 168 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1438, "y" : 168 } } }, "connectors" : [ { "edgeId" : 110618, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1428, "y" : 160 }, "to" : { "x" : 1448, "y" : 131 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110621, "reactomeId" : 10388496, "displayName" : "ESRs:STRN:ESTG:MyrG-pY419-SRC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1622, "y" : 114 }, "minX" : 1496, "maxX" : 1700, "minY" : 82, "maxY" : 180, "prop" : { "x" : 1551, "y" : 88, "width" : 143, "height" : 52 }, "textPosition" : { "x" : 1565, "y" : 105 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1694, "y" : 88 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1694, "y" : 88 } } }, "connectors" : [ { "edgeId" : 110618, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1548, "y" : 123 }, "to" : { "x" : 1496, "y" : 131 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1542, "y" : 128 }, "b" : { "x" : 1548, "y" : 123 }, "c" : { "x" : 1541, "y" : 120 }, "type" : "ARROW", "centre" : { "x" : 1541, "y" : 120 } } }, { "edgeId" : 110622, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1628, "y" : 143 }, "to" : { "x" : 1638, "y" : 180 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110620, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1517, "y" : 166 }, "minX" : 1496, "maxX" : 1539, "minY" : 131, "maxY" : 184, "prop" : { "x" : 1497, "y" : 148, "width" : 41, "height" : 36 }, "textPosition" : { "x" : 1501, "y" : 155 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1533, "y" : 153 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1533, "y" : 153 } } }, "connectors" : [ { "edgeId" : 110618, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1506, "y" : 145 }, "to" : { "x" : 1496, "y" : 131 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1499, "y" : 142 }, "b" : { "x" : 1506, "y" : 145 }, "c" : { "x" : 1505, "y" : 137 }, "type" : "ARROW", "centre" : { "x" : 1505, "y" : 137 } } } ] }, { "id" : 110623, "reactomeId" : 10341420, "displayName" : "PI3K alpha", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1438, "y" : 290 }, "minX" : 1375, "maxX" : 1638, "minY" : 180, "maxY" : 304, "prop" : { "x" : 1375, "y" : 277, "width" : 126, "height" : 27 }, "textPosition" : { "x" : 1401, "y" : 283 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1501, "y" : 277 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1501, "y" : 277 } } }, "connectors" : [ { "edgeId" : 110622, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1462, "y" : 274 }, "to" : { "x" : 1638, "y" : 180 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110624, "reactomeId" : 10388498, "displayName" : "ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1795, "y" : 142 }, "minX" : 1729, "maxX" : 1868, "minY" : 109, "maxY" : 170, "prop" : { "x" : 1729, "y" : 115, "width" : 133, "height" : 55 }, "textPosition" : { "x" : 1738, "y" : 121 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1862, "y" : 115 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1862, "y" : 115 } } }, "connectors" : [ { "edgeId" : 110622, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110627, "reactomeId" : 29468, "displayName" : "L-Arg", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3127, "y" : 640 }, "minX" : 3103, "maxX" : 3154, "minY" : 580, "maxY" : 655, "prop" : { "x" : 3103, "y" : 625, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 3107, "y" : 629 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3146, "y" : 630 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3146, "y" : 630 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3133, "y" : 622 }, "to" : { "x" : 3154, "y" : 580 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3137, "y" : 595 }, "b" : { "x" : 3149, "y" : 607 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3143, "y" : 601 } } } } ] }, { "id" : 110626, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3071, "y" : 579 }, "minX" : 3053, "maxX" : 3154, "minY" : 563, "maxY" : 594, "prop" : { "x" : 3053, "y" : 564, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 3058, "y" : 568 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3084, "y" : 569 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3084, "y" : 569 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3092, "y" : 579 }, "to" : { "x" : 3154, "y" : 580 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 110629, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3093, "y" : 535 }, "minX" : 3066, "maxX" : 3154, "minY" : 519, "maxY" : 580, "prop" : { "x" : 3066, "y" : 520, "width" : 55, "height" : 30 }, "textPosition" : { "x" : 3068, "y" : 524 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3116, "y" : 525 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3116, "y" : 525 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3113, "y" : 553 }, "to" : { "x" : 3154, "y" : 580 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 3127, "y" : 560 }, "b" : { "x" : 3139, "y" : 572 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3133, "y" : 566 } } } } ] }, { "id" : 110628, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3065, "y" : 621 }, "minX" : 3047, "maxX" : 3154, "minY" : 580, "maxY" : 637, "prop" : { "x" : 3047, "y" : 606, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 3051, "y" : 611 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3078, "y" : 611 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3078, "y" : 611 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3086, "y" : 612 }, "to" : { "x" : 3154, "y" : 580 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 110631, "reactomeId" : 29968, "displayName" : "L-Cit", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3363, "y" : 643 }, "minX" : 3267, "maxX" : 3392, "minY" : 581, "maxY" : 660, "prop" : { "x" : 3336, "y" : 627, "width" : 55, "height" : 33 }, "textPosition" : { "x" : 3346, "y" : 633 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3386, "y" : 632 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3386, "y" : 632 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3337, "y" : 624 }, "to" : { "x" : 3267, "y" : 581 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3296, "y" : 596 }, "b" : { "x" : 3308, "y" : 608 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3302, "y" : 602 } } }, "endShape" : { "a" : { "x" : 3329, "y" : 624 }, "b" : { "x" : 3337, "y" : 624 }, "c" : { "x" : 3333, "y" : 617 }, "type" : "ARROW", "centre" : { "x" : 3333, "y" : 617 } } } ] }, { "id" : 110630, "reactomeId" : 202124, "displayName" : "NO", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3369, "y" : 583 }, "minX" : 3267, "maxX" : 3392, "minY" : 567, "maxY" : 599, "prop" : { "x" : 3348, "y" : 568, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 3356, "y" : 573 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3386, "y" : 573 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3386, "y" : 573 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3345, "y" : 582 }, "to" : { "x" : 3267, "y" : 581 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3300, "y" : 575 }, "b" : { "x" : 3312, "y" : 587 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3306, "y" : 581 } } }, "endShape" : { "a" : { "x" : 3338, "y" : 586 }, "b" : { "x" : 3345, "y" : 582 }, "c" : { "x" : 3338, "y" : 578 }, "type" : "ARROW", "centre" : { "x" : 3338, "y" : 578 } } } ] }, { "id" : 110633, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3344, "y" : 520 }, "minX" : 3267, "maxX" : 3375, "minY" : 505, "maxY" : 581, "prop" : { "x" : 3314, "y" : 506, "width" : 60, "height" : 29 }, "textPosition" : { "x" : 3318, "y" : 510 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3369, "y" : 511 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3369, "y" : 511 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3325, "y" : 538 }, "to" : { "x" : 3267, "y" : 581 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 3290, "y" : 553 }, "b" : { "x" : 3302, "y" : 565 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3296, "y" : 559 } } }, "endShape" : { "a" : { "x" : 3322, "y" : 545 }, "b" : { "x" : 3325, "y" : 538 }, "c" : { "x" : 3317, "y" : 539 }, "type" : "ARROW", "centre" : { "x" : 3317, "y" : 539 } } } ] }, { "id" : 110632, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3290, "y" : 655 }, "minX" : 3267, "maxX" : 3313, "minY" : 581, "maxY" : 671, "prop" : { "x" : 3269, "y" : 640, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 3273, "y" : 645 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3307, "y" : 645 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3307, "y" : 645 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3285, "y" : 637 }, "to" : { "x" : 3267, "y" : 581 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 3270, "y" : 603 }, "b" : { "x" : 3282, "y" : 615 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3276, "y" : 609 } } }, "endShape" : { "a" : { "x" : 3279, "y" : 632 }, "b" : { "x" : 3285, "y" : 637 }, "c" : { "x" : 3287, "y" : 629 }, "type" : "ARROW", "centre" : { "x" : 3287, "y" : 629 } } } ], "trivial" : true }, { "id" : 110635, "reactomeId" : 5693375, "displayName" : "ADMA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3199, "y" : 660 }, "minX" : 3171, "maxX" : 3229, "minY" : 589, "maxY" : 675, "prop" : { "x" : 3171, "y" : 645, "width" : 57, "height" : 30 }, "textPosition" : { "x" : 3178, "y" : 649 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3223, "y" : 650 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3223, "y" : 650 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 3199, "y" : 642 }, "to" : { "x" : 3202, "y" : 589 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3198, "y" : 589 }, "b" : { "x" : 3206, "y" : 589 }, "c" : { "x" : 3202, "y" : 589 }, "type" : "STOP", "centre" : { "x" : 3202, "y" : 589 } } } ] }, { "id" : 110634, "reactomeId" : 10352243, "displayName" : "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3199, "y" : 487 }, "minX" : 3125, "maxX" : 3279, "minY" : 462, "maxY" : 572, "prop" : { "x" : 3125, "y" : 468, "width" : 148, "height" : 39 }, "textPosition" : { "x" : 3133, "y" : 472 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3273, "y" : 468 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3273, "y" : 468 } } }, "connectors" : [ { "edgeId" : 110625, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3199, "y" : 510 }, "to" : { "x" : 3201, "y" : 564 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3201, "y" : 568 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3201, "y" : 568 } } } ] }, { "id" : 110637, "reactomeId" : 10351170, "displayName" : "phospho-FOXO3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1665, "y" : 1064 }, "minX" : 1614, "maxX" : 1722, "minY" : 1036, "maxY" : 1086, "prop" : { "x" : 1614, "y" : 1042, "width" : 102, "height" : 44 }, "textPosition" : { "x" : 1631, "y" : 1046 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1716, "y" : 1042 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1716, "y" : 1042 } } }, "connectors" : [ { "edgeId" : 110636, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110638, "reactomeId" : 10432135, "displayName" : "phospho-FOXO3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2101, "y" : 1064 }, "minX" : 2051, "maxX" : 2157, "minY" : 1040, "maxY" : 1082, "prop" : { "x" : 2051, "y" : 1046, "width" : 100, "height" : 36 }, "textPosition" : { "x" : 2067, "y" : 1046 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2151, "y" : 1046 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2151, "y" : 1046 } } }, "connectors" : [ { "edgeId" : 110636, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110641, "reactomeId" : 10351927, "displayName" : "PTK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2377, "y" : 489 }, "minX" : 2311, "maxX" : 2403, "minY" : 472, "maxY" : 500, "prop" : { "x" : 2357, "y" : 478, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 2358, "y" : 478 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2397, "y" : 478 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2397, "y" : 478 } } }, "connectors" : [ { "edgeId" : 110639, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2354, "y" : 488 }, "to" : { "x" : 2311, "y" : 488 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110640, "reactomeId" : 10347513, "displayName" : "EGF-like ligands:p-6Y EGFR dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2311, "y" : 438 }, "minX" : 2250, "maxX" : 2378, "minY" : 414, "maxY" : 488, "prop" : { "x" : 2250, "y" : 420, "width" : 122, "height" : 36 }, "textPosition" : { "x" : 2250, "y" : 421 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2372, "y" : 420 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2372, "y" : 420 } } }, "connectors" : [ { "edgeId" : 110639, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2311, "y" : 459 }, "to" : { "x" : 2311, "y" : 488 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110642, "reactomeId" : 10432383, "displayName" : "EGF-like ligands:p-6Y EGFR:PTK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2327, "y" : 554 }, "minX" : 2254, "maxX" : 2394, "minY" : 530, "maxY" : 625, "prop" : { "x" : 2266, "y" : 536, "width" : 122, "height" : 36 }, "textPosition" : { "x" : 2266, "y" : 537 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2388, "y" : 536 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2388, "y" : 536 } } }, "connectors" : [ { "edgeId" : 110639, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110643, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2329, "y" : 575 }, "to" : { "x" : 2334, "y" : 597 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110643, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2303, "y" : 575 }, "to" : { "x" : 2254, "y" : 610 } }, { "from" : { "x" : 2254, "y" : 610 }, "to" : { "x" : 2323, "y" : 621 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2327, "y" : 621 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2327, "y" : 621 } } } ] }, { "id" : 110645, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2434, "y" : 636 }, "minX" : 2363, "maxX" : 2456, "minY" : 620, "maxY" : 655, "prop" : { "x" : 2414, "y" : 621, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2418, "y" : 625 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2450, "y" : 626 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2450, "y" : 626 } } }, "connectors" : [ { "edgeId" : 110643, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2411, "y" : 641 }, "to" : { "x" : 2363, "y" : 655 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2405, "y" : 647 }, "b" : { "x" : 2411, "y" : 641 }, "c" : { "x" : 2403, "y" : 639 }, "type" : "ARROW", "centre" : { "x" : 2403, "y" : 639 } } } ] }, { "id" : 110644, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2461, "y" : 554 }, "minX" : 2334, "maxX" : 2482, "minY" : 538, "maxY" : 597, "prop" : { "x" : 2441, "y" : 539, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2445, "y" : 543 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2476, "y" : 544 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2476, "y" : 544 } } }, "connectors" : [ { "edgeId" : 110643, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2438, "y" : 560 }, "to" : { "x" : 2334, "y" : 597 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110646, "reactomeId" : 10432387, "displayName" : "EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2364, "y" : 714 }, "minX" : 2303, "maxX" : 2431, "minY" : 655, "maxY" : 739, "prop" : { "x" : 2303, "y" : 689, "width" : 122, "height" : 50 }, "textPosition" : { "x" : 2303, "y" : 690 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2425, "y" : 689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2425, "y" : 689 } } }, "connectors" : [ { "edgeId" : 110643, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2363, "y" : 686 }, "to" : { "x" : 2363, "y" : 655 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2359, "y" : 679 }, "b" : { "x" : 2363, "y" : 686 }, "c" : { "x" : 2367, "y" : 679 }, "type" : "ARROW", "centre" : { "x" : 2367, "y" : 679 } } } ] }, { "id" : 110649, "reactomeId" : 71285, "displayName" : "AdoHcy", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 319, "y" : 306 }, "minX" : 243, "maxX" : 362, "minY" : 233, "maxY" : 323, "prop" : { "x" : 278, "y" : 290, "width" : 83, "height" : 33 }, "textPosition" : { "x" : 292, "y" : 296 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 356, "y" : 295 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 356, "y" : 295 } } }, "connectors" : [ { "edgeId" : 110647, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 301, "y" : 287 }, "to" : { "x" : 243, "y" : 233 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 293, "y" : 285 }, "b" : { "x" : 301, "y" : 287 }, "c" : { "x" : 299, "y" : 279 }, "type" : "ARROW", "centre" : { "x" : 299, "y" : 279 } } } ] }, { "id" : 110648, "reactomeId" : 5279190, "displayName" : "AdoMet", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 178, "y" : 294 }, "minX" : 147, "maxX" : 211, "minY" : 234, "maxY" : 309, "prop" : { "x" : 147, "y" : 279, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 151, "y" : 283 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 205, "y" : 284 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 205, "y" : 284 } } }, "connectors" : [ { "edgeId" : 110647, "type" : "INPUT", "segments" : [ { "from" : { "x" : 183, "y" : 276 }, "to" : { "x" : 199, "y" : 234 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110650, "reactomeId" : 10432661, "displayName" : "PRMT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 235, "y" : 311 }, "minX" : 208, "maxX" : 269, "minY" : 241, "maxY" : 322, "prop" : { "x" : 208, "y" : 300, "width" : 55, "height" : 22 }, "textPosition" : { "x" : 211, "y" : 300 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 263, "y" : 300 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 263, "y" : 300 } } }, "connectors" : [ { "edgeId" : 110647, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 233, "y" : 297 }, "to" : { "x" : 225, "y" : 249 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 225, "y" : 245 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 225, "y" : 245 } } } ] }, { "id" : 110653, "reactomeId" : 10432666, "displayName" : "Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1661, "y" : 244 }, "minX" : 1588, "maxX" : 1775, "minY" : 207, "maxY" : 276, "prop" : { "x" : 1588, "y" : 213, "width" : 147, "height" : 63 }, "textPosition" : { "x" : 1598, "y" : 227 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1735, "y" : 213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1735, "y" : 213 } } }, "connectors" : [ { "edgeId" : 110651, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1738, "y" : 245 }, "to" : { "x" : 1775, "y" : 247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110652, "reactomeId" : 10432669, "displayName" : "phospho-pY-PTK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1743, "y" : 312 }, "minX" : 1704, "maxX" : 1788, "minY" : 247, "maxY" : 326, "prop" : { "x" : 1704, "y" : 298, "width" : 78, "height" : 28 }, "textPosition" : { "x" : 1709, "y" : 295 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1782, "y" : 298 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1782, "y" : 298 } } }, "connectors" : [ { "edgeId" : 110651, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1749, "y" : 295 }, "to" : { "x" : 1775, "y" : 247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110654, "reactomeId" : 10432671, "displayName" : "Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1913, "y" : 243 }, "minX" : 1831, "maxX" : 2001, "minY" : 209, "maxY" : 272, "prop" : { "x" : 1831, "y" : 215, "width" : 164, "height" : 57 }, "textPosition" : { "x" : 1830, "y" : 223 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1995, "y" : 215 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1995, "y" : 215 } } }, "connectors" : [ { "edgeId" : 110651, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110657, "reactomeId" : 10432675, "displayName" : "PDPK1:PIP3:p-T410-PRKCZ", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3053, "y" : 275 }, "minX" : 3021, "maxX" : 3125, "minY" : 222, "maxY" : 309, "prop" : { "x" : 3021, "y" : 242, "width" : 64, "height" : 67 }, "textPosition" : { "x" : 3027, "y" : 246 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3085, "y" : 242 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3085, "y" : 242 } } }, "connectors" : [ { "edgeId" : 110655, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3088, "y" : 275 }, "to" : { "x" : 3111, "y" : 276 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110655, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3074, "y" : 239 }, "to" : { "x" : 3087, "y" : 222 } }, { "from" : { "x" : 3087, "y" : 222 }, "to" : { "x" : 3118, "y" : 262 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3121, "y" : 266 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3121, "y" : 266 } } } ] }, { "id" : 110656, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3091, "y" : 339 }, "minX" : 3065, "maxX" : 3119, "minY" : 276, "maxY" : 357, "prop" : { "x" : 3065, "y" : 322, "width" : 53, "height" : 35 }, "textPosition" : { "x" : 3076, "y" : 329 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3113, "y" : 327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3113, "y" : 327 } } }, "connectors" : [ { "edgeId" : 110655, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3096, "y" : 319 }, "to" : { "x" : 3111, "y" : 276 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110659, "reactomeId" : 10432680, "displayName" : "PDPK1:PIP3:pS, p-T410 PRKCZ", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3228, "y" : 272 }, "minX" : 3146, "maxX" : 3301, "minY" : 240, "maxY" : 298, "prop" : { "x" : 3181, "y" : 246, "width" : 94, "height" : 52 }, "textPosition" : { "x" : 3186, "y" : 249 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3275, "y" : 246 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3275, "y" : 246 } } }, "connectors" : [ { "edgeId" : 110670, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3278, "y" : 269 }, "to" : { "x" : 3301, "y" : 268 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110655, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3178, "y" : 273 }, "to" : { "x" : 3146, "y" : 274 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3171, "y" : 277 }, "b" : { "x" : 3178, "y" : 273 }, "c" : { "x" : 3171, "y" : 269 }, "type" : "ARROW", "centre" : { "x" : 3171, "y" : 269 } } } ] }, { "id" : 110658, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3177, "y" : 334 }, "minX" : 3146, "maxX" : 3209, "minY" : 274, "maxY" : 352, "prop" : { "x" : 3146, "y" : 317, "width" : 62, "height" : 35 }, "textPosition" : { "x" : 3160, "y" : 324 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3203, "y" : 322 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3203, "y" : 322 } } }, "connectors" : [ { "edgeId" : 110655, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3167, "y" : 314 }, "to" : { "x" : 3146, "y" : 274 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3160, "y" : 310 }, "b" : { "x" : 3167, "y" : 314 }, "c" : { "x" : 3167, "y" : 306 }, "type" : "ARROW", "centre" : { "x" : 3167, "y" : 306 } } } ] }, { "id" : 110661, "reactomeId" : 10333660, "displayName" : "CDKN1B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1529, "y" : 531 }, "minX" : 1498, "maxX" : 1592, "minY" : 510, "maxY" : 546, "prop" : { "x" : 1498, "y" : 516, "width" : 62, "height" : 30 }, "textPosition" : { "x" : 1500, "y" : 520 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1560, "y" : 516 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1560, "y" : 516 } } }, "connectors" : [ { "edgeId" : 110660, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1563, "y" : 534 }, "to" : { "x" : 1592, "y" : 538 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110663, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1712, "y" : 575 }, "minX" : 1671, "maxX" : 1743, "minY" : 537, "maxY" : 593, "prop" : { "x" : 1683, "y" : 558, "width" : 59, "height" : 35 }, "textPosition" : { "x" : 1696, "y" : 565 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1737, "y" : 563 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1737, "y" : 563 } } }, "connectors" : [ { "edgeId" : 110660, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1693, "y" : 555 }, "to" : { "x" : 1671, "y" : 537 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1685, "y" : 554 }, "b" : { "x" : 1693, "y" : 555 }, "c" : { "x" : 1690, "y" : 548 }, "type" : "ARROW", "centre" : { "x" : 1690, "y" : 548 } } } ] }, { "id" : 110662, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1553, "y" : 592 }, "minX" : 1530, "maxX" : 1592, "minY" : 538, "maxY" : 607, "prop" : { "x" : 1530, "y" : 577, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 1537, "y" : 581 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1571, "y" : 582 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1571, "y" : 582 } } }, "connectors" : [ { "edgeId" : 110660, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1563, "y" : 574 }, "to" : { "x" : 1592, "y" : 538 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110665, "reactomeId" : 10432690, "displayName" : "UHMK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1672, "y" : 497 }, "minX" : 1625, "maxX" : 1718, "minY" : 479, "maxY" : 535, "prop" : { "x" : 1633, "y" : 485, "width" : 79, "height" : 25 }, "textPosition" : { "x" : 1647, "y" : 487 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1712, "y" : 485 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1712, "y" : 485 } } }, "connectors" : [ { "edgeId" : 110660, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1655, "y" : 513 }, "to" : { "x" : 1632, "y" : 529 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1629, "y" : 531 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1629, "y" : 531 } } } ] }, { "id" : 110664, "reactomeId" : 10432686, "displayName" : "phospho-CDKN1B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1769, "y" : 530 }, "minX" : 1671, "maxX" : 1813, "minY" : 504, "maxY" : 551, "prop" : { "x" : 1731, "y" : 510, "width" : 76, "height" : 41 }, "textPosition" : { "x" : 1735, "y" : 513 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1807, "y" : 510 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1807, "y" : 510 } } }, "connectors" : [ { "edgeId" : 110660, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1728, "y" : 532 }, "to" : { "x" : 1671, "y" : 537 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1721, "y" : 537 }, "b" : { "x" : 1728, "y" : 532 }, "c" : { "x" : 1721, "y" : 529 }, "type" : "ARROW", "centre" : { "x" : 1721, "y" : 529 } } }, { "edgeId" : 110666, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110667, "reactomeId" : 10432695, "displayName" : "phospho-CDKN1B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2098, "y" : 519 }, "minX" : 2045, "maxX" : 2157, "minY" : 493, "maxY" : 539, "prop" : { "x" : 2045, "y" : 499, "width" : 106, "height" : 40 }, "textPosition" : { "x" : 2064, "y" : 501 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2151, "y" : 499 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2151, "y" : 499 } } }, "connectors" : [ { "edgeId" : 110666, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110669, "reactomeId" : 10350300, "displayName" : "p-Y185,Y187 MAPK1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1870, "y" : 614 }, "minX" : 1809, "maxX" : 1938, "minY" : 532, "maxY" : 631, "prop" : { "x" : 1809, "y" : 597, "width" : 123, "height" : 34 }, "textPosition" : { "x" : 1825, "y" : 596 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1932, "y" : 597 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1932, "y" : 597 } } }, "connectors" : [ { "edgeId" : 110666, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1869, "y" : 594 }, "to" : { "x" : 1867, "y" : 532 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1871, "y" : 539 }, "b" : { "x" : 1867, "y" : 532 }, "c" : { "x" : 1863, "y" : 539 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1863, "y" : 539 } } }, { "edgeId" : 110675, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110668, "reactomeId" : 10345676, "displayName" : "XPO1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1873, "y" : 486 }, "minX" : 1842, "maxX" : 1910, "minY" : 469, "maxY" : 514, "prop" : { "x" : 1842, "y" : 475, "width" : 62, "height" : 23 }, "textPosition" : { "x" : 1853, "y" : 476 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1904, "y" : 475 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1904, "y" : 475 } } }, "connectors" : [ { "edgeId" : 110666, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1871, "y" : 501 }, "to" : { "x" : 1869, "y" : 514 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1866, "y" : 507 }, "b" : { "x" : 1869, "y" : 514 }, "c" : { "x" : 1874, "y" : 508 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1874, "y" : 508 } } } ] }, { "id" : 110671, "reactomeId" : 10347614, "displayName" : "p21 RAS:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3247, "y" : 195 }, "minX" : 3207, "maxX" : 3301, "minY" : 169, "maxY" : 268, "prop" : { "x" : 3207, "y" : 175, "width" : 81, "height" : 40 }, "textPosition" : { "x" : 3215, "y" : 180 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3288, "y" : 175 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3288, "y" : 175 } } }, "connectors" : [ { "edgeId" : 110670, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3261, "y" : 218 }, "to" : { "x" : 3301, "y" : 268 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110672, "reactomeId" : 10432700, "displayName" : "PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3397, "y" : 267 }, "minX" : 3345, "maxX" : 3456, "minY" : 231, "maxY" : 298, "prop" : { "x" : 3345, "y" : 237, "width" : 105, "height" : 61 }, "textPosition" : { "x" : 3344, "y" : 249 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3450, "y" : 237 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3450, "y" : 237 } } }, "connectors" : [ { "edgeId" : 110670, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110673, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110674, "reactomeId" : 10432704, "displayName" : "PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3560, "y" : 268 }, "minX" : 2137, "maxX" : 3620, "minY" : 236, "maxY" : 944, "prop" : { "x" : 3506, "y" : 242, "width" : 108, "height" : 53 }, "textPosition" : { "x" : 3506, "y" : 246 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3614, "y" : 242 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3614, "y" : 242 } } }, "connectors" : [ { "edgeId" : 110673, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110675, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 3552, "y" : 298 }, "to" : { "x" : 3389, "y" : 841 } }, { "from" : { "x" : 3389, "y" : 841 }, "to" : { "x" : 2193, "y" : 944 } }, { "from" : { "x" : 2193, "y" : 944 }, "to" : { "x" : 2139, "y" : 747 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2145, "y" : 753 }, "b" : { "x" : 2139, "y" : 747 }, "c" : { "x" : 2137, "y" : 755 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2137, "y" : 755 } } } ] }, { "id" : 110676, "reactomeId" : 10346146, "displayName" : "p-T185,Y187 MAPK1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2547, "y" : 850 }, "minX" : 2501, "maxX" : 2600, "minY" : 826, "maxY" : 868, "prop" : { "x" : 2501, "y" : 832, "width" : 93, "height" : 36 }, "textPosition" : { "x" : 2502, "y" : 833 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2594, "y" : 832 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2594, "y" : 832 } } }, "connectors" : [ { "edgeId" : 110675, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110679, "reactomeId" : 10431372, "displayName" : "PalmS-ESRs:STRN:ESTG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 645, "y" : 250 }, "minX" : 599, "maxX" : 697, "minY" : 226, "maxY" : 269, "prop" : { "x" : 599, "y" : 232, "width" : 92, "height" : 37 }, "textPosition" : { "x" : 602, "y" : 234 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 691, "y" : 232 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 691, "y" : 232 } } }, "connectors" : [ { "edgeId" : 110677, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110678, "reactomeId" : 10388492, "displayName" : "STRN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 531, "y" : 319 }, "minX" : 502, "maxX" : 566, "minY" : 249, "maxY" : 333, "prop" : { "x" : 502, "y" : 306, "width" : 58, "height" : 27 }, "textPosition" : { "x" : 511, "y" : 309 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 560, "y" : 306 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 560, "y" : 306 } } }, "connectors" : [ { "edgeId" : 110677, "type" : "INPUT", "segments" : [ { "from" : { "x" : 535, "y" : 303 }, "to" : { "x" : 556, "y" : 249 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 539, "y" : 270 }, "b" : { "x" : 551, "y" : 282 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 545, "y" : 276 } } } } ] }, { "id" : 110681, "reactomeId" : 10388954, "displayName" : "p-Y1161,1165,1166-IGF1R", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1942, "y" : 124 }, "minX" : 1883, "maxX" : 2075, "minY" : 100, "maxY" : 207, "prop" : { "x" : 1883, "y" : 106, "width" : 118, "height" : 36 }, "textPosition" : { "x" : 1884, "y" : 107 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2001, "y" : 106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2001, "y" : 106 } } }, "connectors" : [ { "edgeId" : 110680, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1970, "y" : 145 }, "to" : { "x" : 2075, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110683, "reactomeId" : 10432339, "displayName" : "ESTG:Me260-ESR1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2071, "y" : 125 }, "minX" : 2015, "maxX" : 2191, "minY" : 101, "maxY" : 245, "prop" : { "x" : 2015, "y" : 107, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 2026, "y" : 108 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2128, "y" : 107 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2128, "y" : 107 } } }, "connectors" : [ { "edgeId" : 110680, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2071, "y" : 146 }, "to" : { "x" : 2075, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110689, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2089, "y" : 146 }, "to" : { "x" : 2191, "y" : 245 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2183, "y" : 243 }, "b" : { "x" : 2191, "y" : 245 }, "c" : { "x" : 2189, "y" : 237 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2189, "y" : 237 } } } ] }, { "id" : 110682, "reactomeId" : 10337721, "displayName" : "SHC1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2010, "y" : 303 }, "minX" : 1989, "maxX" : 2075, "minY" : 207, "maxY" : 317, "prop" : { "x" : 1989, "y" : 289, "width" : 43, "height" : 28 }, "textPosition" : { "x" : 1990, "y" : 292 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2032, "y" : 289 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2032, "y" : 289 } } }, "connectors" : [ { "edgeId" : 110680, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2019, "y" : 283 }, "to" : { "x" : 2075, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110684, "reactomeId" : 10432341, "displayName" : "ESTG:ESR1:p-3Y-IGF1R:SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2221, "y" : 136 }, "minX" : 2151, "maxX" : 2548, "minY" : 108, "maxY" : 197, "prop" : { "x" : 2151, "y" : 114, "width" : 140, "height" : 44 }, "textPosition" : { "x" : 2165, "y" : 123 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2291, "y" : 114 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2291, "y" : 114 } } }, "connectors" : [ { "edgeId" : 110680, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110692, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2294, "y" : 150 }, "to" : { "x" : 2504, "y" : 193 } }, { "from" : { "x" : 2504, "y" : 193 }, "to" : { "x" : 2548, "y" : 193 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2541, "y" : 197 }, "b" : { "x" : 2548, "y" : 193 }, "c" : { "x" : 2541, "y" : 189 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2541, "y" : 189 } } } ] }, { "id" : 110687, "reactomeId" : 10358781, "displayName" : "S1PR3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2334, "y" : 209 }, "minX" : 2298, "maxX" : 2377, "minY" : 183, "maxY" : 250, "prop" : { "x" : 2298, "y" : 189, "width" : 73, "height" : 40 }, "textPosition" : { "x" : 2310, "y" : 198 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2371, "y" : 189 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2371, "y" : 189 } } }, "connectors" : [ { "edgeId" : 110685, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2354, "y" : 232 }, "to" : { "x" : 2375, "y" : 250 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110686, "reactomeId" : 5218688, "displayName" : "S1P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2253, "y" : 250 }, "minX" : 2230, "maxX" : 2375, "minY" : 231, "maxY" : 302, "prop" : { "x" : 2230, "y" : 232, "width" : 46, "height" : 36 }, "textPosition" : { "x" : 2237, "y" : 239 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2271, "y" : 237 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2271, "y" : 237 } } }, "connectors" : [ { "edgeId" : 110685, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2279, "y" : 263 }, "to" : { "x" : 2339, "y" : 302 } }, { "from" : { "x" : 2339, "y" : 302 }, "to" : { "x" : 2375, "y" : 250 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110689, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110688, "reactomeId" : 10432335, "displayName" : "S1P:S1PR3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2472, "y" : 244 }, "minX" : 2439, "maxX" : 2549, "minY" : 197, "maxY" : 264, "prop" : { "x" : 2439, "y" : 225, "width" : 67, "height" : 39 }, "textPosition" : { "x" : 2448, "y" : 229 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2506, "y" : 225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2506, "y" : 225 } } }, "connectors" : [ { "edgeId" : 110685, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110692, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2504, "y" : 222 }, "to" : { "x" : 2549, "y" : 197 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2545, "y" : 204 }, "b" : { "x" : 2549, "y" : 197 }, "c" : { "x" : 2541, "y" : 197 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2541, "y" : 197 } } } ] }, { "id" : 110691, "reactomeId" : 10361004, "displayName" : "SPHK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2198, "y" : 327 }, "minX" : 2164, "maxX" : 2239, "minY" : 259, "maxY" : 344, "prop" : { "x" : 2164, "y" : 310, "width" : 69, "height" : 34 }, "textPosition" : { "x" : 2174, "y" : 316 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2233, "y" : 310 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2233, "y" : 310 } } }, "connectors" : [ { "edgeId" : 110689, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2197, "y" : 307 }, "to" : { "x" : 2197, "y" : 267 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2197, "y" : 263 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2197, "y" : 263 } } } ] }, { "id" : 110690, "reactomeId" : 1606609, "displayName" : "SPG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2109, "y" : 252 }, "minX" : 2070, "maxX" : 2150, "minY" : 231, "maxY" : 273, "prop" : { "x" : 2070, "y" : 232, "width" : 79, "height" : 41 }, "textPosition" : { "x" : 2093, "y" : 242 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2144, "y" : 237 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2144, "y" : 237 } } }, "connectors" : [ { "edgeId" : 110689, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110693, "reactomeId" : 10432328, "displayName" : "HBEGF", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2560, "y" : 271 }, "minX" : 2525, "maxX" : 2602, "minY" : 242, "maxY" : 295, "prop" : { "x" : 2525, "y" : 248, "width" : 71, "height" : 47 }, "textPosition" : { "x" : 2536, "y" : 261 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2596, "y" : 248 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2596, "y" : 248 } } }, "connectors" : [ { "edgeId" : 110692, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110695, "reactomeId" : 10347453, "displayName" : "HBEGF", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2617, "y" : 68 }, "minX" : 2560, "maxX" : 2680, "minY" : 46, "maxY" : 163, "prop" : { "x" : 2560, "y" : 52, "width" : 114, "height" : 33 }, "textPosition" : { "x" : 2592, "y" : 58 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2674, "y" : 52 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2674, "y" : 52 } } }, "connectors" : [ { "edgeId" : 110692, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2607, "y" : 88 }, "to" : { "x" : 2560, "y" : 163 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2607, "y" : 96 }, "b" : { "x" : 2607, "y" : 88 }, "c" : { "x" : 2600, "y" : 92 }, "type" : "ARROW", "centre" : { "x" : 2600, "y" : 92 } } } ] }, { "id" : 110694, "reactomeId" : 10432330, "displayName" : "HBEGF", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2524, "y" : 113 }, "minX" : 2488, "maxX" : 2567, "minY" : 85, "maxY" : 163, "prop" : { "x" : 2488, "y" : 91, "width" : 73, "height" : 45 }, "textPosition" : { "x" : 2500, "y" : 103 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2561, "y" : 91 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2561, "y" : 91 } } }, "connectors" : [ { "edgeId" : 110692, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2540, "y" : 139 }, "to" : { "x" : 2560, "y" : 163 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2548, "y" : 142 }, "b" : { "x" : 2540, "y" : 139 }, "c" : { "x" : 2541, "y" : 147 }, "type" : "ARROW", "centre" : { "x" : 2541, "y" : 147 } } } ] }, { "id" : 110696, "reactomeId" : 10432332, "displayName" : "MMP2,3,7,9", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2380, "y" : 56 }, "minX" : 2340, "maxX" : 2551, "minY" : 45, "maxY" : 190, "prop" : { "x" : 2340, "y" : 45, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 2340, "y" : 45 }, "connectors" : [ { "edgeId" : 110692, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2394, "y" : 73 }, "to" : { "x" : 2544, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2547, "y" : 186 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2547, "y" : 186 } } } ] }, { "id" : 110699, "reactomeId" : 10443392, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2709, "y" : 190 }, "minX" : 2638, "maxX" : 2780, "minY" : 157, "maxY" : 223, "prop" : { "x" : 2638, "y" : 157, "width" : 142, "height" : 66 }, "textPosition" : { "x" : 2642, "y" : 168 }, "connectors" : [ ] }, { "id" : 110702, "reactomeId" : 10444138, "displayName" : "Metabolism of nitric oxide: NOS3 activation and regulation", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2927, "y" : 511 }, "minX" : 2844, "maxX" : 3011, "minY" : 470, "maxY" : 552, "prop" : { "x" : 2844, "y" : 470, "width" : 167, "height" : 82 }, "textPosition" : { "x" : 2847, "y" : 482 }, "connectors" : [ ] }, { "id" : 110707, "reactomeId" : 10419546, "displayName" : "CCND1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1691, "y" : 1319 }, "minX" : 1657, "maxX" : 1732, "minY" : 1300, "maxY" : 1333, "prop" : { "x" : 1657, "y" : 1306, "width" : 69, "height" : 27 }, "textPosition" : { "x" : 1666, "y" : 1309 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1726, "y" : 1306 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1726, "y" : 1306 } } }, "connectors" : [ ] }, { "id" : 110711, "reactomeId" : 10443230, "displayName" : "Signaling by EGFR", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2591, "y" : 494 }, "minX" : 2523, "maxX" : 2660, "minY" : 467, "maxY" : 521, "prop" : { "x" : 2523, "y" : 467, "width" : 137, "height" : 54 }, "textPosition" : { "x" : 2528, "y" : 479 }, "connectors" : [ ] }, { "id" : 110591, "reactomeId" : 10431040, "displayName" : "ESRs:HSBP1 oligomer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 503, "y" : 686 }, "minX" : 461, "maxX" : 552, "minY" : 640, "maxY" : 709, "prop" : { "x" : 461, "y" : 663, "width" : 85, "height" : 46 }, "textPosition" : { "x" : 460, "y" : 674 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 546, "y" : 663 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 546, "y" : 663 } } }, "connectors" : [ { "edgeId" : 110602, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 110589, "type" : "INPUT", "segments" : [ { "from" : { "x" : 505, "y" : 660 }, "to" : { "x" : 508, "y" : 640 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110590, "reactomeId" : 200993, "displayName" : "PALM-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 576, "y" : 654 }, "minX" : 508, "maxX" : 608, "minY" : 635, "maxY" : 673, "prop" : { "x" : 546, "y" : 636, "width" : 61, "height" : 37 }, "textPosition" : { "x" : 554, "y" : 637 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 602, "y" : 641 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 602, "y" : 641 } } }, "connectors" : [ { "edgeId" : 110589, "type" : "INPUT", "segments" : [ { "from" : { "x" : 543, "y" : 647 }, "to" : { "x" : 508, "y" : 640 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 110718, "reactomeId" : 10350309, "displayName" : "p-T,Y MAPK dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1441, "y" : 668 }, "minX" : 1377, "maxX" : 1506, "minY" : 656, "maxY" : 681, "prop" : { "x" : 1377, "y" : 656, "width" : 129, "height" : 25 }, "textPosition" : { "x" : 1381, "y" : 658 }, "connectors" : [ ] } ], "edges" : [ { "id" : 110596, "reactomeId" : 10431065, "displayName" : "PalmS-ESRs bind CAVs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 404, "y" : 465 }, "minX" : 265, "maxX" : 446, "minY" : 459, "maxY" : 501, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 446, "y" : 501 }, "to" : { "x" : 404, "y" : 465 } }, { "from" : { "x" : 404, "y" : 465 }, "to" : { "x" : 265, "y" : 484 } } ], "endShape" : { "a" : { "x" : 271, "y" : 479 }, "b" : { "x" : 265, "y" : 484 }, "c" : { "x" : 272, "y" : 487 }, "type" : "ARROW", "centre" : { "x" : 272, "y" : 487 } }, "reactionShape" : { "c" : { "x" : 404, "y" : 465 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 404, "y" : 465 } }, "inputs" : [ { "id" : 110593, "points" : [ { "x" : 456, "y" : 525 } ] }, { "id" : 110597, "points" : [ { "x" : 413, "y" : 511 } ] } ], "outputs" : [ { "id" : 110598 } ] }, { "id" : 110660, "reactomeId" : 10432693, "displayName" : "CDKN1B is phosphorylated in response to estrogen", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1619, "y" : 538 }, "minX" : 1592, "maxX" : 1671, "minY" : 532, "maxY" : 544, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1592, "y" : 538 }, "to" : { "x" : 1619, "y" : 538 } }, { "from" : { "x" : 1619, "y" : 538 }, "to" : { "x" : 1671, "y" : 537 } } ], "reactionShape" : { "a" : { "x" : 1613, "y" : 532 }, "b" : { "x" : 1625, "y" : 544 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1619, "y" : 538 } }, "inputs" : [ { "id" : 110661, "points" : [ { "x" : 1563, "y" : 534 } ] }, { "id" : 110662, "points" : [ { "x" : 1563, "y" : 574 } ] } ], "outputs" : [ { "id" : 110663, "points" : [ { "x" : 1693, "y" : 555 } ] }, { "id" : 110664, "points" : [ { "x" : 1728, "y" : 532 } ] } ], "catalysts" : [ { "id" : 110665, "points" : [ { "x" : 1655, "y" : 513 } ] } ] }, { "id" : 110599, "reactomeId" : 10431088, "displayName" : "PalmS-ESRs:CAVs translocate to plasma membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 150, "y" : 382 }, "minX" : 114, "maxX" : 208, "minY" : 318, "maxY" : 469, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 208, "y" : 469 }, "to" : { "x" : 150, "y" : 382 } }, { "from" : { "x" : 150, "y" : 382 }, "to" : { "x" : 114, "y" : 318 } } ], "reactionShape" : { "a" : { "x" : 144, "y" : 376 }, "b" : { "x" : 156, "y" : 388 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 150, "y" : 382 } }, "inputs" : [ { "id" : 110598 } ], "outputs" : [ { "id" : 110600, "points" : [ { "x" : 92, "y" : 312 } ] }, { "id" : 110601, "points" : [ { "x" : 98, "y" : 244 } ] } ] }, { "id" : 110602, "reactomeId" : 10431042, "displayName" : "HSBP1 oligomer binds ESRs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 503, "y" : 741 }, "minX" : 497, "maxX" : 509, "minY" : 712, "maxY" : 761, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 501, "y" : 761 }, "to" : { "x" : 503, "y" : 741 } }, { "from" : { "x" : 503, "y" : 741 }, "to" : { "x" : 503, "y" : 712 } } ], "endShape" : { "a" : { "x" : 507, "y" : 719 }, "b" : { "x" : 503, "y" : 712 }, "c" : { "x" : 499, "y" : 719 }, "type" : "ARROW", "centre" : { "x" : 499, "y" : 719 } }, "reactionShape" : { "c" : { "x" : 503, "y" : 741 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 503, "y" : 741 } }, "inputs" : [ { "id" : 110594, "points" : [ { "x" : 556, "y" : 789 } ] }, { "id" : 110603, "points" : [ { "x" : 474, "y" : 783 } ] } ], "outputs" : [ { "id" : 110591 } ] }, { "id" : 110666, "reactomeId" : 10432697, "displayName" : "p-S10 CDKN1B translocates to the cytosol", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1867, "y" : 523 }, "minX" : 1810, "maxX" : 2042, "minY" : 517, "maxY" : 529, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1810, "y" : 527 }, "to" : { "x" : 1867, "y" : 523 } }, { "from" : { "x" : 1867, "y" : 523 }, "to" : { "x" : 2042, "y" : 519 } } ], "endShape" : { "a" : { "x" : 2035, "y" : 523 }, "b" : { "x" : 2042, "y" : 519 }, "c" : { "x" : 2035, "y" : 515 }, "type" : "ARROW", "centre" : { "x" : 2035, "y" : 515 } }, "reactionShape" : { "a" : { "x" : 1861, "y" : 517 }, "b" : { "x" : 1873, "y" : 529 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1867, "y" : 523 } }, "inputs" : [ { "id" : 110664 } ], "outputs" : [ { "id" : 110667 } ], "activators" : [ { "id" : 110668, "points" : [ { "x" : 1871, "y" : 501 } ] }, { "id" : 110669, "points" : [ { "x" : 1869, "y" : 594 } ] } ] }, { "id" : 110604, "reactomeId" : 10431103, "displayName" : "Estrogen stimulates dimerization of plasma membrane estrogen receptors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 441, "y" : 185 }, "minX" : 419, "maxX" : 464, "minY" : 179, "maxY" : 220, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 419, "y" : 188 }, "to" : { "x" : 441, "y" : 185 } }, { "from" : { "x" : 441, "y" : 185 }, "to" : { "x" : 464, "y" : 220 } } ], "endShape" : { "a" : { "x" : 457, "y" : 216 }, "b" : { "x" : 464, "y" : 220 }, "c" : { "x" : 464, "y" : 212 }, "type" : "ARROW", "centre" : { "x" : 464, "y" : 212 } }, "reactionShape" : { "c" : { "x" : 441, "y" : 185 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 441, "y" : 185 } }, "inputs" : [ { "id" : 110605, "points" : [ { "x" : 118, "y" : 50 } ], "stoichiometry" : 2 }, { "id" : 110606, "points" : [ { "x" : 371, "y" : 220 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 110607 } ] }, { "id" : 110670, "reactomeId" : 10432702, "displayName" : "PRKCZ recruits RAS in response to estrogen stimulation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3317, "y" : 265 }, "minX" : 3301, "maxX" : 3342, "minY" : 259, "maxY" : 271, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3301, "y" : 268 }, "to" : { "x" : 3317, "y" : 265 } }, { "from" : { "x" : 3317, "y" : 265 }, "to" : { "x" : 3342, "y" : 265 } } ], "endShape" : { "a" : { "x" : 3335, "y" : 269 }, "b" : { "x" : 3342, "y" : 265 }, "c" : { "x" : 3335, "y" : 261 }, "type" : "ARROW", "centre" : { "x" : 3335, "y" : 261 } }, "reactionShape" : { "c" : { "x" : 3317, "y" : 265 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3317, "y" : 265 } }, "inputs" : [ { "id" : 110659, "points" : [ { "x" : 3278, "y" : 269 } ] }, { "id" : 110671, "points" : [ { "x" : 3261, "y" : 218 } ] } ], "outputs" : [ { "id" : 110672 } ] }, { "id" : 110673, "reactomeId" : 10432709, "displayName" : "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3476, "y" : 265 }, "minX" : 3453, "maxX" : 3503, "minY" : 259, "maxY" : 271, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3453, "y" : 265 }, "to" : { "x" : 3476, "y" : 265 } }, { "from" : { "x" : 3476, "y" : 265 }, "to" : { "x" : 3503, "y" : 266 } } ], "endShape" : { "a" : { "x" : 3496, "y" : 270 }, "b" : { "x" : 3503, "y" : 266 }, "c" : { "x" : 3496, "y" : 262 }, "type" : "ARROW", "centre" : { "x" : 3496, "y" : 262 } }, "reactionShape" : { "a" : { "x" : 3470, "y" : 259 }, "b" : { "x" : 3482, "y" : 271 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3476, "y" : 265 } }, "inputs" : [ { "id" : 110672 } ], "outputs" : [ { "id" : 110674 } ] }, { "id" : 110608, "reactomeId" : 10431129, "displayName" : "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 895, "y" : 186 }, "minX" : 863, "maxX" : 923, "minY" : 180, "maxY" : 202, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 863, "y" : 202 }, "to" : { "x" : 895, "y" : 186 } }, { "from" : { "x" : 895, "y" : 186 }, "to" : { "x" : 923, "y" : 180 } } ], "endShape" : { "a" : { "x" : 917, "y" : 185 }, "b" : { "x" : 923, "y" : 180 }, "c" : { "x" : 915, "y" : 178 }, "type" : "ARROW", "centre" : { "x" : 915, "y" : 178 } }, "reactionShape" : { "c" : { "x" : 895, "y" : 186 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 895, "y" : 186 } }, "inputs" : [ { "id" : 110609, "points" : [ { "x" : 839, "y" : 282 } ] }, { "id" : 110610, "points" : [ { "x" : 829, "y" : 191 } ] } ], "outputs" : [ { "id" : 110611 } ] }, { "id" : 110675, "reactomeId" : 10432706, "displayName" : "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2137, "y" : 738 }, "minX" : 1906, "maxX" : 2498, "minY" : 634, "maxY" : 837, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2498, "y" : 837 }, "to" : { "x" : 2137, "y" : 738 } }, { "from" : { "x" : 2137, "y" : 738 }, "to" : { "x" : 1906, "y" : 634 } } ], "endShape" : { "a" : { "x" : 1914, "y" : 633 }, "b" : { "x" : 1906, "y" : 634 }, "c" : { "x" : 1911, "y" : 640 }, "type" : "ARROW", "centre" : { "x" : 1911, "y" : 640 } }, "reactionShape" : { "a" : { "x" : 2131, "y" : 732 }, "b" : { "x" : 2143, "y" : 744 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2137, "y" : 738 } }, "inputs" : [ { "id" : 110676 } ], "outputs" : [ { "id" : 110669 } ], "activators" : [ { "id" : 110674, "points" : [ { "x" : 3552, "y" : 298 }, { "x" : 3389, "y" : 841 }, { "x" : 2193, "y" : 944 } ] } ] }, { "id" : 110677, "reactomeId" : 10432711, "displayName" : "ESR binds STRN", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 568, "y" : 247 }, "minX" : 556, "maxX" : 596, "minY" : 241, "maxY" : 253, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 556, "y" : 249 }, "to" : { "x" : 568, "y" : 247 } }, { "from" : { "x" : 568, "y" : 247 }, "to" : { "x" : 596, "y" : 248 } } ], "endShape" : { "a" : { "x" : 589, "y" : 252 }, "b" : { "x" : 596, "y" : 248 }, "c" : { "x" : 589, "y" : 244 }, "type" : "ARROW", "centre" : { "x" : 589, "y" : 244 } }, "reactionShape" : { "c" : { "x" : 568, "y" : 247 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 568, "y" : 247 } }, "inputs" : [ { "id" : 110678, "points" : [ { "x" : 535, "y" : 303 } ], "stoichiometry" : 2 }, { "id" : 110607, "points" : [ { "x" : 540, "y" : 248 } ] } ], "outputs" : [ { "id" : 110679 } ] }, { "id" : 110612, "reactomeId" : 10431127, "displayName" : "G-proteins dissociate from plasma-membrane estrogen receptors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1093, "y" : 177 }, "minX" : 1045, "maxX" : 1108, "minY" : 171, "maxY" : 205, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 1045, "y" : 173 }, "to" : { "x" : 1093, "y" : 177 } }, { "from" : { "x" : 1093, "y" : 177 }, "to" : { "x" : 1108, "y" : 205 } } ], "reactionShape" : { "c" : { "x" : 1093, "y" : 177 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 1093, "y" : 177 } }, "inputs" : [ { "id" : 110611 } ], "outputs" : [ { "id" : 110613, "points" : [ { "x" : 1192, "y" : 154 } ] }, { "id" : 110614, "points" : [ { "x" : 1140, "y" : 246 } ] }, { "id" : 110609, "points" : [ { "x" : 884, "y" : 285 } ] } ] }, { "id" : 110615, "reactomeId" : 10431121, "displayName" : "Membrane estrogen receptors bind SRC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1236, "y" : 334 }, "minX" : 1060, "maxX" : 1352, "minY" : 161, "maxY" : 340, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1060, "y" : 320 }, "to" : { "x" : 1236, "y" : 334 } }, { "from" : { "x" : 1236, "y" : 334 }, "to" : { "x" : 1285, "y" : 283 } }, { "from" : { "x" : 1285, "y" : 283 }, "to" : { "x" : 1352, "y" : 161 } } ], "endShape" : { "a" : { "x" : 1352, "y" : 169 }, "b" : { "x" : 1352, "y" : 161 }, "c" : { "x" : 1345, "y" : 165 }, "type" : "ARROW", "centre" : { "x" : 1345, "y" : 165 } }, "reactionShape" : { "c" : { "x" : 1236, "y" : 334 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1236, "y" : 334 } }, "inputs" : [ { "id" : 110616, "points" : [ { "x" : 1045, "y" : 288 } ] }, { "id" : 110609, "points" : [ { "x" : 884, "y" : 305 } ] } ], "outputs" : [ { "id" : 110617 } ], "activators" : [ { "id" : 110614, "points" : [ { "x" : 1177, "y" : 289 } ] }, { "id" : 110613, "points" : [ { "x" : 1223, "y" : 154 } ] } ] }, { "id" : 110680, "reactomeId" : 10432729, "displayName" : "Estrogen receptor binds IGF1R and SHC1 in response to estrogen", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2111, "y" : 195 }, "minX" : 2075, "maxX" : 2179, "minY" : 161, "maxY" : 207, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2075, "y" : 207 }, "to" : { "x" : 2111, "y" : 195 } }, { "from" : { "x" : 2111, "y" : 195 }, "to" : { "x" : 2179, "y" : 161 } } ], "endShape" : { "a" : { "x" : 2175, "y" : 168 }, "b" : { "x" : 2179, "y" : 161 }, "c" : { "x" : 2171, "y" : 161 }, "type" : "ARROW", "centre" : { "x" : 2171, "y" : 161 } }, "reactionShape" : { "a" : { "x" : 2105, "y" : 189 }, "b" : { "x" : 2117, "y" : 201 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2111, "y" : 195 } }, "inputs" : [ { "id" : 110681, "points" : [ { "x" : 1970, "y" : 145 } ] }, { "id" : 110682, "points" : [ { "x" : 2019, "y" : 283 } ] }, { "id" : 110683, "points" : [ { "x" : 2071, "y" : 146 } ] } ], "outputs" : [ { "id" : 110684 } ] }, { "id" : 110618, "reactomeId" : 10431132, "displayName" : "ESR-associated SRC autophosphorylates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1470, "y" : 130 }, "minX" : 1448, "maxX" : 1496, "minY" : 124, "maxY" : 136, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1448, "y" : 131 }, "to" : { "x" : 1470, "y" : 130 } }, { "from" : { "x" : 1470, "y" : 130 }, "to" : { "x" : 1496, "y" : 131 } } ], "reactionShape" : { "a" : { "x" : 1464, "y" : 124 }, "b" : { "x" : 1476, "y" : 136 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1470, "y" : 130 } }, "inputs" : [ { "id" : 110617, "points" : [ { "x" : 1428, "y" : 132 } ] }, { "id" : 110619, "points" : [ { "x" : 1428, "y" : 160 } ] } ], "outputs" : [ { "id" : 110620, "points" : [ { "x" : 1506, "y" : 145 } ] }, { "id" : 110621, "points" : [ { "x" : 1548, "y" : 123 } ] } ], "catalysts" : [ { "id" : 110617, "points" : [ { "x" : 1394, "y" : 115 }, { "x" : 1461, "y" : 76 } ] } ] }, { "id" : 110685, "reactomeId" : 10432392, "displayName" : "S1P binds S1PR3 in response to E2 stimulation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2404, "y" : 251 }, "minX" : 2375, "maxX" : 2436, "minY" : 245, "maxY" : 257, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2375, "y" : 250 }, "to" : { "x" : 2404, "y" : 251 } }, { "from" : { "x" : 2404, "y" : 251 }, "to" : { "x" : 2436, "y" : 247 } } ], "endShape" : { "a" : { "x" : 2430, "y" : 252 }, "b" : { "x" : 2436, "y" : 247 }, "c" : { "x" : 2429, "y" : 244 }, "type" : "ARROW", "centre" : { "x" : 2429, "y" : 244 } }, "reactionShape" : { "c" : { "x" : 2404, "y" : 251 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2404, "y" : 251 } }, "inputs" : [ { "id" : 110686, "points" : [ { "x" : 2279, "y" : 263 }, { "x" : 2339, "y" : 302 } ] }, { "id" : 110687, "points" : [ { "x" : 2354, "y" : 232 } ] } ], "outputs" : [ { "id" : 110688 } ] }, { "id" : 110622, "reactomeId" : 10431152, "displayName" : "PI3K binds membrane-associated estrogen receptors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1664, "y" : 169 }, "minX" : 1638, "maxX" : 1726, "minY" : 155, "maxY" : 180, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1638, "y" : 180 }, "to" : { "x" : 1664, "y" : 169 } }, { "from" : { "x" : 1664, "y" : 169 }, "to" : { "x" : 1726, "y" : 155 } } ], "endShape" : { "a" : { "x" : 1720, "y" : 160 }, "b" : { "x" : 1726, "y" : 155 }, "c" : { "x" : 1718, "y" : 153 }, "type" : "ARROW", "centre" : { "x" : 1718, "y" : 153 } }, "reactionShape" : { "c" : { "x" : 1664, "y" : 169 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1664, "y" : 169 } }, "inputs" : [ { "id" : 110623, "points" : [ { "x" : 1462, "y" : 274 } ] }, { "id" : 110621, "points" : [ { "x" : 1628, "y" : 143 } ] } ], "outputs" : [ { "id" : 110624 } ] }, { "id" : 110689, "reactomeId" : 10432395, "displayName" : "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2197, "y" : 251 }, "minX" : 2152, "maxX" : 2227, "minY" : 245, "maxY" : 257, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2152, "y" : 251 }, "to" : { "x" : 2197, "y" : 251 } }, { "from" : { "x" : 2197, "y" : 251 }, "to" : { "x" : 2227, "y" : 250 } } ], "endShape" : { "a" : { "x" : 2220, "y" : 254 }, "b" : { "x" : 2227, "y" : 250 }, "c" : { "x" : 2220, "y" : 246 }, "type" : "ARROW", "centre" : { "x" : 2220, "y" : 246 } }, "reactionShape" : { "a" : { "x" : 2191, "y" : 245 }, "b" : { "x" : 2203, "y" : 257 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2197, "y" : 251 } }, "inputs" : [ { "id" : 110690 } ], "outputs" : [ { "id" : 110686 } ], "catalysts" : [ { "id" : 110691, "points" : [ { "x" : 2197, "y" : 307 } ] } ], "activators" : [ { "id" : 110683, "points" : [ { "x" : 2089, "y" : 146 } ] } ] }, { "id" : 110625, "reactomeId" : 10352246, "displayName" : "eNOS synthesizes NO", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3202, "y" : 580 }, "minX" : 3154, "maxX" : 3267, "minY" : 574, "maxY" : 586, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3154, "y" : 580 }, "to" : { "x" : 3202, "y" : 580 } }, { "from" : { "x" : 3202, "y" : 580 }, "to" : { "x" : 3267, "y" : 581 } } ], "reactionShape" : { "a" : { "x" : 3196, "y" : 574 }, "b" : { "x" : 3208, "y" : 586 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3202, "y" : 580 } }, "inputs" : [ { "id" : 110626, "points" : [ { "x" : 3092, "y" : 579 } ] }, { "id" : 110627, "points" : [ { "x" : 3133, "y" : 622 } ], "stoichiometry" : 2 }, { "id" : 110628, "points" : [ { "x" : 3086, "y" : 612 } ] }, { "id" : 110629, "points" : [ { "x" : 3113, "y" : 553 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 110630, "points" : [ { "x" : 3345, "y" : 582 } ], "stoichiometry" : 2 }, { "id" : 110631, "points" : [ { "x" : 3337, "y" : 624 } ], "stoichiometry" : 2 }, { "id" : 110632, "points" : [ { "x" : 3285, "y" : 637 } ], "stoichiometry" : 4 }, { "id" : 110633, "points" : [ { "x" : 3325, "y" : 538 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 110634, "points" : [ { "x" : 3199, "y" : 510 } ] } ], "inhibitors" : [ { "id" : 110635, "points" : [ { "x" : 3199, "y" : 642 } ] } ] }, { "id" : 110692, "reactomeId" : 10432343, "displayName" : "MMPs cleave HB-EGF", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2557, "y" : 193 }, "minX" : 2551, "maxX" : 2563, "minY" : 163, "maxY" : 245, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2559, "y" : 245 }, "to" : { "x" : 2557, "y" : 193 } }, { "from" : { "x" : 2557, "y" : 193 }, "to" : { "x" : 2560, "y" : 163 } } ], "reactionShape" : { "a" : { "x" : 2551, "y" : 187 }, "b" : { "x" : 2563, "y" : 199 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2557, "y" : 193 } }, "inputs" : [ { "id" : 110693 } ], "outputs" : [ { "id" : 110694, "points" : [ { "x" : 2540, "y" : 139 } ] }, { "id" : 110695, "points" : [ { "x" : 2607, "y" : 88 } ] } ], "catalysts" : [ { "id" : 110696, "points" : [ { "x" : 2394, "y" : 73 } ] } ], "activators" : [ { "id" : 110688, "points" : [ { "x" : 2504, "y" : 222 } ] }, { "id" : 110684, "points" : [ { "x" : 2294, "y" : 150 }, { "x" : 2504, "y" : 193 } ] } ] }, { "id" : 110636, "reactomeId" : 10432347, "displayName" : "AKT-phosphorylated FOXO3 translocates to cytosol", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1745, "y" : 1061 }, "minX" : 1719, "maxX" : 2048, "minY" : 1055, "maxY" : 1067, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1719, "y" : 1062 }, "to" : { "x" : 1745, "y" : 1061 } }, { "from" : { "x" : 1745, "y" : 1061 }, "to" : { "x" : 2048, "y" : 1063 } } ], "endShape" : { "a" : { "x" : 2041, "y" : 1067 }, "b" : { "x" : 2048, "y" : 1063 }, "c" : { "x" : 2041, "y" : 1059 }, "type" : "ARROW", "centre" : { "x" : 2041, "y" : 1059 } }, "reactionShape" : { "a" : { "x" : 1739, "y" : 1055 }, "b" : { "x" : 1751, "y" : 1067 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1745, "y" : 1061 } }, "inputs" : [ { "id" : 110637 } ], "outputs" : [ { "id" : 110638 } ] }, { "id" : 110639, "reactomeId" : 10432385, "displayName" : "PTK2 binds activated EGFR", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2314, "y" : 510 }, "minX" : 2308, "maxX" : 2321, "minY" : 488, "maxY" : 533, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2311, "y" : 488 }, "to" : { "x" : 2314, "y" : 510 } }, { "from" : { "x" : 2314, "y" : 510 }, "to" : { "x" : 2321, "y" : 533 } } ], "endShape" : { "a" : { "x" : 2315, "y" : 528 }, "b" : { "x" : 2321, "y" : 533 }, "c" : { "x" : 2323, "y" : 525 }, "type" : "ARROW", "centre" : { "x" : 2323, "y" : 525 } }, "reactionShape" : { "c" : { "x" : 2314, "y" : 510 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2314, "y" : 510 } }, "inputs" : [ { "id" : 110640, "points" : [ { "x" : 2311, "y" : 459 } ] }, { "id" : 110641, "points" : [ { "x" : 2354, "y" : 488 } ] } ], "outputs" : [ { "id" : 110642 } ] }, { "id" : 110643, "reactomeId" : 10432390, "displayName" : "PTK2 autophosphorylates downstream of EGFR", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2339, "y" : 623 }, "minX" : 2333, "maxX" : 2363, "minY" : 597, "maxY" : 655, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2334, "y" : 597 }, "to" : { "x" : 2339, "y" : 623 } }, { "from" : { "x" : 2339, "y" : 623 }, "to" : { "x" : 2363, "y" : 655 } } ], "reactionShape" : { "a" : { "x" : 2333, "y" : 617 }, "b" : { "x" : 2345, "y" : 629 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2339, "y" : 623 } }, "inputs" : [ { "id" : 110642, "points" : [ { "x" : 2329, "y" : 575 } ] }, { "id" : 110644, "points" : [ { "x" : 2438, "y" : 560 } ] } ], "outputs" : [ { "id" : 110645, "points" : [ { "x" : 2411, "y" : 641 } ] }, { "id" : 110646, "points" : [ { "x" : 2363, "y" : 686 } ] } ], "catalysts" : [ { "id" : 110642, "points" : [ { "x" : 2303, "y" : 575 }, { "x" : 2254, "y" : 610 } ] } ] }, { "id" : 110647, "reactomeId" : 10432664, "displayName" : "PRMT1 methylates ESRs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 223, "y" : 233 }, "minX" : 199, "maxX" : 243, "minY" : 227, "maxY" : 239, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 199, "y" : 234 }, "to" : { "x" : 223, "y" : 233 } }, { "from" : { "x" : 223, "y" : 233 }, "to" : { "x" : 243, "y" : 233 } } ], "reactionShape" : { "a" : { "x" : 217, "y" : 227 }, "b" : { "x" : 229, "y" : 239 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 223, "y" : 233 } }, "inputs" : [ { "id" : 110648, "points" : [ { "x" : 183, "y" : 276 } ] }, { "id" : 110601, "points" : [ { "x" : 149, "y" : 229 } ] } ], "outputs" : [ { "id" : 110649, "points" : [ { "x" : 301, "y" : 287 } ] }, { "id" : 110606, "points" : [ { "x" : 285, "y" : 239 } ] } ], "catalysts" : [ { "id" : 110650, "points" : [ { "x" : 233, "y" : 297 } ] } ], "activators" : [ { "id" : 110605, "points" : [ { "x" : 100, "y" : 57 } ] } ] }, { "id" : 110651, "reactomeId" : 10432673, "displayName" : "PTK2 is recruited to methylated ESR1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1798, "y" : 245 }, "minX" : 1775, "maxX" : 1828, "minY" : 239, "maxY" : 251, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1775, "y" : 247 }, "to" : { "x" : 1798, "y" : 245 } }, { "from" : { "x" : 1798, "y" : 245 }, "to" : { "x" : 1828, "y" : 244 } } ], "endShape" : { "a" : { "x" : 1821, "y" : 248 }, "b" : { "x" : 1828, "y" : 244 }, "c" : { "x" : 1821, "y" : 240 }, "type" : "ARROW", "centre" : { "x" : 1821, "y" : 240 } }, "reactionShape" : { "c" : { "x" : 1798, "y" : 245 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1798, "y" : 245 } }, "inputs" : [ { "id" : 110652, "points" : [ { "x" : 1749, "y" : 295 } ] }, { "id" : 110653, "points" : [ { "x" : 1738, "y" : 245 } ] } ], "outputs" : [ { "id" : 110654 } ] }, { "id" : 110589, "reactomeId" : 10431074, "displayName" : "ZDHHC7, ZDHHC21 palmitoylate ESR1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 506, "y" : 610 }, "minX" : 500, "maxX" : 512, "minY" : 578, "maxY" : 640, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 508, "y" : 640 }, "to" : { "x" : 506, "y" : 610 } }, { "from" : { "x" : 506, "y" : 610 }, "to" : { "x" : 506, "y" : 578 } } ], "reactionShape" : { "a" : { "x" : 500, "y" : 604 }, "b" : { "x" : 512, "y" : 616 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 506, "y" : 610 } }, "inputs" : [ { "id" : 110590, "points" : [ { "x" : 543, "y" : 647 } ] }, { "id" : 110591, "points" : [ { "x" : 505, "y" : 660 } ] } ], "outputs" : [ { "id" : 110592, "points" : [ { "x" : 555, "y" : 555 } ] }, { "id" : 110593, "points" : [ { "x" : 478, "y" : 564 } ] }, { "id" : 110594, "points" : [ { "x" : 583, "y" : 789 }, { "x" : 641, "y" : 582 } ] } ], "catalysts" : [ { "id" : 110595, "points" : [ { "x" : 441, "y" : 613 } ] } ] }, { "id" : 110655, "reactomeId" : 10432683, "displayName" : "PRKCZ autophosphorylates downstream of estrogen stimulation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3128, "y" : 275 }, "minX" : 3111, "maxX" : 3146, "minY" : 269, "maxY" : 281, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3111, "y" : 276 }, "to" : { "x" : 3128, "y" : 275 } }, { "from" : { "x" : 3128, "y" : 275 }, "to" : { "x" : 3146, "y" : 274 } } ], "reactionShape" : { "a" : { "x" : 3122, "y" : 269 }, "b" : { "x" : 3134, "y" : 281 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3128, "y" : 275 } }, "inputs" : [ { "id" : 110656, "points" : [ { "x" : 3096, "y" : 319 } ] }, { "id" : 110657, "points" : [ { "x" : 3088, "y" : 275 } ] } ], "outputs" : [ { "id" : 110658, "points" : [ { "x" : 3167, "y" : 314 } ] }, { "id" : 110659, "points" : [ { "x" : 3178, "y" : 273 } ] } ], "catalysts" : [ { "id" : 110657, "points" : [ { "x" : 3074, "y" : 239 }, { "x" : 3087, "y" : 222 } ] } ] } ], "compartments" : [ { "id" : 110710, "reactomeId" : 17906, "displayName" : "mitochondrial outer membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2133, "y" : 1195 }, "minX" : 2078, "maxX" : 2189, "minY" : 1134, "maxY" : 1257, "prop" : { "x" : 2078, "y" : 1134, "width" : 111, "height" : 123 }, "textPosition" : { "x" : 2084, "y" : 1167 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 110697, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1828, "y" : 831 }, "minX" : 0, "maxX" : 3656, "minY" : 131, "maxY" : 1532, "prop" : { "x" : 0, "y" : 131, "width" : 3656, "height" : 1401 }, "textPosition" : { "x" : 752, "y" : 741 }, "insets" : { "x" : 10, "y" : 141, "width" : 3636, "height" : 1381 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 110698, 110593, 110596, 110599, 110600, 110601, 110679, 110611, 110613, 110614, 110604, 110615, 110616, 110617, 110610, 110620, 110619, 110623, 110624, 110699, 110609, 110608, 110702, 110625, 110629, 110626, 110627, 110634, 110729, 110703, 110591, 110602, 110603, 110590, 110589, 110592, 110594, 110710, 110635, 110682, 110711, 110730, 110731, 110732, 110639, 110640, 110641, 110642, 110733, 110643, 110644, 110645, 110646, 110720, 110735, 110686, 110688, 110687, 110647, 110648, 110649, 110650, 110653, 110612, 110622, 110654, 110652, 110657, 110726, 110737, 110655, 110656, 110658, 110659, 110621, 110651, 110638, 110633, 110630, 110631, 110670, 110671, 110672, 110734, 110673, 110674, 110676, 110677, 110678, 110684, 110680, 110683, 110681, 110607, 110740, 110685, 110606, 110689, 110690, 110691, 110692, 110693, 110694, 110667, 110675, 110736, 110632, 110628 ] }, { "id" : 110698, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 277, "y" : 574 }, "minX" : 161, "maxX" : 393, "minY" : 486, "maxY" : 663, "prop" : { "x" : 161, "y" : 486, "width" : 232, "height" : 177 }, "textPosition" : { "x" : 220, "y" : 604 }, "insets" : { "x" : 171, "y" : 496, "width" : 212, "height" : 157 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 110595, 110597, 110598 ] }, { "id" : 110703, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1495, "y" : 916 }, "minX" : 998, "maxX" : 1992, "minY" : 414, "maxY" : 1419, "prop" : { "x" : 998, "y" : 414, "width" : 994, "height" : 1005 }, "textPosition" : { "x" : 1097, "y" : 511 }, "insets" : { "x" : 1008, "y" : 424, "width" : 974, "height" : 985 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 110637, 110636, 110718, 110707, 110727, 110738, 110666, 110668, 110669, 110664, 110660, 110663, 110665, 110661, 110662, 110739 ] } ], "notes" : [ ], "links" : [ { "id" : 110737, "renderableClass" : "Interaction", "position" : { "x" : 2742, "y" : 241 }, "minX" : 2731, "maxX" : 2754, "minY" : 226, "maxY" : 257, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2731, "y" : 226 }, "to" : { "x" : 2754, "y" : 257 } } ], "endShape" : { "a" : { "x" : 2747, "y" : 254 }, "b" : { "x" : 2754, "y" : 257 }, "c" : { "x" : 2753, "y" : 249 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2753, "y" : 249 } }, "reactionShape" : { "a" : { "x" : 2736, "y" : 235 }, "b" : { "x" : 2748, "y" : 247 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2742, "y" : 241 } }, "inputs" : [ { "id" : 110699 } ], "outputs" : [ { "id" : 110726 } ] }, { "id" : 110736, "renderableClass" : "Interaction", "position" : { "x" : 1930, "y" : 384 }, "minX" : 1441, "maxX" : 2561, "minY" : 378, "maxY" : 650, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2561, "y" : 583 }, "to" : { "x" : 2399, "y" : 383 } }, { "from" : { "x" : 2399, "y" : 383 }, "to" : { "x" : 1461, "y" : 386 } }, { "from" : { "x" : 1461, "y" : 386 }, "to" : { "x" : 1441, "y" : 650 } } ], "endShape" : { "a" : { "x" : 1438, "y" : 643 }, "b" : { "x" : 1441, "y" : 650 }, "c" : { "x" : 1446, "y" : 643 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1446, "y" : 643 } }, "reactionShape" : { "a" : { "x" : 1924, "y" : 378 }, "b" : { "x" : 1936, "y" : 390 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1930, "y" : 384 } }, "inputs" : [ { "id" : 110720 } ], "outputs" : [ { "id" : 110718 } ] }, { "id" : 110739, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1659, "y" : 640 }, "minX" : 1512, "maxX" : 1806, "minY" : 621, "maxY" : 659, "segments" : [ { "from" : { "x" : 1806, "y" : 621 }, "to" : { "x" : 1512, "y" : 659 } } ], "reactionShape" : { "a" : { "x" : 1653, "y" : 634 }, "b" : { "x" : 1665, "y" : 646 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1659, "y" : 640 } }, "inputs" : [ { "id" : 110669 } ], "outputs" : [ { "id" : 110718 } ] }, { "id" : 110738, "renderableClass" : "Interaction", "position" : { "x" : 1755, "y" : 1316 }, "minX" : 1729, "maxX" : 1781, "minY" : 1310, "maxY" : 1322, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1729, "y" : 1317 }, "to" : { "x" : 1781, "y" : 1316 } } ], "endShape" : { "a" : { "x" : 1774, "y" : 1320 }, "b" : { "x" : 1781, "y" : 1316 }, "c" : { "x" : 1774, "y" : 1312 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1774, "y" : 1312 } }, "reactionShape" : { "a" : { "x" : 1749, "y" : 1310 }, "b" : { "x" : 1761, "y" : 1322 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1755, "y" : 1316 } }, "inputs" : [ { "id" : 110707 } ], "outputs" : [ { "id" : 110727 } ] }, { "id" : 110740, "renderableClass" : "Interaction", "position" : { "x" : 2564, "y" : 739 }, "minX" : 2549, "maxX" : 2579, "minY" : 649, "maxY" : 829, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2579, "y" : 649 }, "to" : { "x" : 2549, "y" : 829 } } ], "endShape" : { "a" : { "x" : 2546, "y" : 822 }, "b" : { "x" : 2549, "y" : 829 }, "c" : { "x" : 2554, "y" : 823 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2554, "y" : 823 } }, "reactionShape" : { "a" : { "x" : 2558, "y" : 733 }, "b" : { "x" : 2570, "y" : 745 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2564, "y" : 739 } }, "inputs" : [ { "id" : 110720 } ], "outputs" : [ { "id" : 110676 } ] }, { "id" : 110729, "renderableClass" : "Interaction", "position" : { "x" : 3068, "y" : 498 }, "minX" : 3014, "maxX" : 3122, "minY" : 492, "maxY" : 504, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 3014, "y" : 503 }, "to" : { "x" : 3122, "y" : 493 } } ], "endShape" : { "a" : { "x" : 3115, "y" : 498 }, "b" : { "x" : 3122, "y" : 493 }, "c" : { "x" : 3115, "y" : 490 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 3115, "y" : 490 } }, "reactionShape" : { "a" : { "x" : 3062, "y" : 492 }, "b" : { "x" : 3074, "y" : 504 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3068, "y" : 498 } }, "inputs" : [ { "id" : 110702 } ], "outputs" : [ { "id" : 110634 } ] }, { "id" : 110728, "renderableClass" : "Interaction", "position" : { "x" : 2288, "y" : 6 }, "minX" : 1811, "maxX" : 2707, "minY" : 0, "maxY" : 154, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1811, "y" : 112 }, "to" : { "x" : 1879, "y" : 4 } }, { "from" : { "x" : 1879, "y" : 4 }, "to" : { "x" : 2698, "y" : 8 } }, { "from" : { "x" : 2698, "y" : 8 }, "to" : { "x" : 2707, "y" : 154 } } ], "endShape" : { "a" : { "x" : 2703, "y" : 147 }, "b" : { "x" : 2707, "y" : 154 }, "c" : { "x" : 2711, "y" : 147 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2711, "y" : 147 } }, "reactionShape" : { "a" : { "x" : 2282, "y" : 0 }, "b" : { "x" : 2294, "y" : 12 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2288, "y" : 6 } }, "inputs" : [ { "id" : 110624 } ], "outputs" : [ { "id" : 110699 } ] }, { "id" : 110731, "renderableClass" : "FlowLine", "position" : { "x" : 2648, "y" : 345 }, "minX" : 2601, "maxX" : 2695, "minY" : 226, "maxY" : 464, "segments" : [ { "from" : { "x" : 2601, "y" : 464 }, "to" : { "x" : 2695, "y" : 226 } } ], "endShape" : { "a" : { "x" : 2696, "y" : 234 }, "b" : { "x" : 2695, "y" : 226 }, "c" : { "x" : 2689, "y" : 231 }, "type" : "ARROW", "centre" : { "x" : 2689, "y" : 231 } }, "reactionShape" : { "a" : { "x" : 2642, "y" : 339 }, "b" : { "x" : 2654, "y" : 351 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2648, "y" : 345 } }, "inputs" : [ { "id" : 110711 } ], "outputs" : [ { "id" : 110699 } ] }, { "id" : 110730, "renderableClass" : "Interaction", "position" : { "x" : 2603, "y" : 276 }, "minX" : 2592, "maxX" : 2615, "minY" : 88, "maxY" : 464, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2615, "y" : 88 }, "to" : { "x" : 2592, "y" : 464 } } ], "endShape" : { "a" : { "x" : 2588, "y" : 457 }, "b" : { "x" : 2592, "y" : 464 }, "c" : { "x" : 2596, "y" : 457 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2596, "y" : 457 } }, "reactionShape" : { "a" : { "x" : 2597, "y" : 270 }, "b" : { "x" : 2609, "y" : 282 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2603, "y" : 276 } }, "inputs" : [ { "id" : 110695 } ], "outputs" : [ { "id" : 110711 } ] }, { "id" : 110733, "renderableClass" : "Interaction", "position" : { "x" : 2447, "y" : 465 }, "minX" : 2375, "maxX" : 2520, "minY" : 450, "maxY" : 480, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2520, "y" : 480 }, "to" : { "x" : 2375, "y" : 450 } } ], "endShape" : { "a" : { "x" : 2383, "y" : 447 }, "b" : { "x" : 2375, "y" : 450 }, "c" : { "x" : 2381, "y" : 455 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2381, "y" : 455 } }, "reactionShape" : { "a" : { "x" : 2441, "y" : 459 }, "b" : { "x" : 2453, "y" : 471 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2447, "y" : 465 } }, "inputs" : [ { "id" : 110711 } ], "outputs" : [ { "id" : 110640 } ] }, { "id" : 110735, "renderableClass" : "FlowLine", "position" : { "x" : 2587, "y" : 553 }, "minX" : 2581, "maxX" : 2593, "minY" : 524, "maxY" : 583, "segments" : [ { "from" : { "x" : 2589, "y" : 524 }, "to" : { "x" : 2586, "y" : 583 } } ], "endShape" : { "a" : { "x" : 2582, "y" : 576 }, "b" : { "x" : 2586, "y" : 583 }, "c" : { "x" : 2590, "y" : 576 }, "type" : "ARROW", "centre" : { "x" : 2590, "y" : 576 } }, "reactionShape" : { "a" : { "x" : 2581, "y" : 547 }, "b" : { "x" : 2593, "y" : 559 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2587, "y" : 553 } }, "inputs" : [ { "id" : 110711 } ], "outputs" : [ { "id" : 110720 } ] }, { "id" : 110734, "renderableClass" : "FlowLine", "position" : { "x" : 2713, "y" : 412 }, "minX" : 2707, "maxX" : 2841, "minY" : 226, "maxY" : 472, "segments" : [ { "from" : { "x" : 2709, "y" : 226 }, "to" : { "x" : 2713, "y" : 412 } }, { "from" : { "x" : 2713, "y" : 412 }, "to" : { "x" : 2841, "y" : 472 } } ], "endShape" : { "a" : { "x" : 2833, "y" : 473 }, "b" : { "x" : 2841, "y" : 472 }, "c" : { "x" : 2836, "y" : 465 }, "type" : "ARROW", "centre" : { "x" : 2836, "y" : 465 } }, "reactionShape" : { "a" : { "x" : 2707, "y" : 406 }, "b" : { "x" : 2719, "y" : 418 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2713, "y" : 412 } }, "inputs" : [ { "id" : 110699 } ], "outputs" : [ { "id" : 110702 } ] } ], "shadows" : [ { "id" : 110741, "reactomeId" : 10446102, "displayName" : "Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1824, "y" : 780 }, "minX" : 1488, "maxX" : 2161, "minY" : 465, "maxY" : 1096, "prop" : { "x" : 1488, "y" : 878, "width" : 673, "height" : 218 }, "points" : [ { "x" : 1488, "y" : 465 }, { "x" : 2161, "y" : 465 }, { "x" : 2161, "y" : 1096 }, { "x" : 1488, "y" : 1096 } ], "colour" : "#4684ee" }, { "id" : 110742, "reactomeId" : 10446110, "displayName" : "Estrogen-stimulated signaling through PRKCZ", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2711, "y" : 521 }, "minX" : 1799, "maxX" : 3624, "minY" : 165, "maxY" : 878, "prop" : { "x" : 2161, "y" : 465, "width" : 1463, "height" : 413 }, "points" : [ { "x" : 1799, "y" : 165 }, { "x" : 3624, "y" : 165 }, { "x" : 3624, "y" : 878 }, { "x" : 1799, "y" : 878 } ], "colour" : "#dc3912" } ], "minX" : 0, "maxX" : 3656, "minY" : 0, "maxY" : 1532, "disease" : false }