{
  "dbId" : 10444076,
  "stId" : "R-BTA-375165",
  "speciesName" : "Bos taurus",
  "nodes" : [ {
    "dbId" : 10346013,
    "stId" : "R-BTA-9647915",
    "displayName" : "KRAS [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BMX0",
    "standardIdentifier" : "uniprot:E1BMX0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "KRAS" ],
    "parents" : [ 10346031 ],
    "children" : [ ]
  }, {
    "dbId" : 10361119,
    "stId" : "R-BTA-391843",
    "displayName" : "NCAM:pFyn-Y420 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10361121 ],
    "children" : [ 10361115, 10361117 ]
  }, {
    "dbId" : 10350300,
    "stId" : "R-BTA-109856",
    "displayName" : "p-Y185,Y187 MAPK1 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10350309 ],
    "children" : [ 10345252 ]
  }, {
    "dbId" : 10350239,
    "stId" : "R-BTA-198657",
    "displayName" : "RPS6KA5 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 59105 ],
    "identifier" : "E1BN61",
    "standardIdentifier" : "uniprot:E1BN61",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10361117,
    "stId" : "R-BTA-391821",
    "displayName" : "phospho-p-Y420-FYN [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0JNB0",
    "standardIdentifier" : "uniprot:A0JNB0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10361119 ],
    "children" : [ ]
  }, {
    "dbId" : 10347614,
    "stId" : "R-BTA-109796",
    "displayName" : "p21 RAS:GDP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 59100 ],
    "parents" : [ ],
    "children" : [ 29420, 10346031 ]
  }, {
    "dbId" : 10361115,
    "stId" : "R-BTA-375103",
    "displayName" : "NCAM1:NCAM1 trans-homotetramer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10361119 ],
    "children" : [ 10361113 ]
  }, {
    "dbId" : 10356185,
    "stId" : "R-BTA-354128",
    "displayName" : "phospho-p-6Y-PTK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MAA1",
    "standardIdentifier" : "uniprot:A0A3Q1MAA1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10361123, 10361125, 10361131 ],
    "children" : [ ]
  }, {
    "dbId" : 10361113,
    "stId" : "R-BTA-190988",
    "displayName" : "NCAM1 cis-homodimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10361115 ],
    "children" : [ 10361111 ]
  }, {
    "dbId" : 10337685,
    "stId" : "R-BTA-64847",
    "displayName" : "SOS1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 59096 ],
    "identifier" : "F1N7C3",
    "standardIdentifier" : "uniprot:F1N7C3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SOS1" ],
    "parents" : [ 10361131 ],
    "children" : [ ]
  }, {
    "dbId" : 10361111,
    "stId" : "R-BTA-190987",
    "displayName" : "Ghost homologue of NCAM1 [plasma membrane]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 48898,
    "parents" : [ 10361113 ],
    "children" : [ ]
  }, {
    "dbId" : 10361109,
    "stId" : "R-BTA-391839",
    "displayName" : "SPTA:SPTB [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10361121 ],
    "children" : [ 10361089, 10361107 ]
  }, {
    "dbId" : 10337681,
    "stId" : "R-BTA-74686",
    "displayName" : "GRB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 59093 ],
    "identifier" : "Q3T0F9",
    "standardIdentifier" : "uniprot:Q3T0F9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GRB2" ],
    "parents" : [ 10361131, 10361125 ],
    "children" : [ ]
  }, {
    "dbId" : 10361107,
    "stId" : "R-BTA-420050",
    "displayName" : "Spectrin beta chain [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10361109 ],
    "children" : [ 10361105, 10361093, 10361097, 10361101 ]
  }, {
    "dbId" : 10361105,
    "stId" : "R-BTA-420044",
    "displayName" : "SPTBN4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BLT3",
    "standardIdentifier" : "uniprot:E1BLT3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SPTBN4" ],
    "parents" : [ 10361107 ],
    "children" : [ ]
  }, {
    "dbId" : 10361101,
    "stId" : "R-BTA-420049",
    "displayName" : "SPTBN2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BMN5",
    "standardIdentifier" : "uniprot:E1BMN5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SPTBN2" ],
    "parents" : [ 10361107 ],
    "children" : [ ]
  }, {
    "dbId" : 10361097,
    "stId" : "R-BTA-420048",
    "displayName" : "SPTBN1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MYC9",
    "standardIdentifier" : "uniprot:F1MYC9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10361107 ],
    "children" : [ ]
  }, {
    "dbId" : 10361093,
    "stId" : "R-BTA-391565",
    "displayName" : "SPTB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MKE9",
    "standardIdentifier" : "uniprot:F1MKE9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SPTB" ],
    "parents" : [ 10361107 ],
    "children" : [ ]
  }, {
    "dbId" : 10361089,
    "stId" : "R-BTA-420046",
    "displayName" : "Spectrin alpha chain [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10361109 ],
    "children" : [ 10352930, 10361087 ]
  }, {
    "dbId" : 10361087,
    "stId" : "R-BTA-391563",
    "displayName" : "SPTA1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "F1MMQ8",
    "standardIdentifier" : "uniprot:F1MMQ8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SPTA1" ],
    "parents" : [ 10361089 ],
    "children" : [ ]
  }, {
    "dbId" : 10361083,
    "stId" : "R-BTA-388755",
    "displayName" : "PTPRA [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A0A3Q1MK12",
    "standardIdentifier" : "uniprot:A0A3Q1MK12",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10361121 ],
    "children" : [ ]
  }, {
    "dbId" : 10445620,
    "stId" : "R-BTA-5673001",
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "speciesId" : 48898,
    "diagramIds" : [ 59137 ]
  }, {
    "dbId" : 29420,
    "stId" : "R-ALL-29420",
    "displayName" : "GDP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 59102 ],
    "identifier" : "58189",
    "standardIdentifier" : "chebi:58189",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10347614 ],
    "children" : [ ]
  }, {
    "dbId" : 10346033,
    "stId" : "R-BTA-109783",
    "displayName" : "p21 RAS:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 59101 ],
    "parents" : [ ],
    "children" : [ 10346031, 29438 ]
  }, {
    "dbId" : 29358,
    "stId" : "R-ALL-29358",
    "displayName" : "ATP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 59104, 59110 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113582,
    "stId" : "R-ALL-113582",
    "displayName" : "ADP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 59106, 59112 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10346031,
    "stId" : "R-BTA-9649715",
    "displayName" : "mature p21 RAS [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "parents" : [ 10347614, 10346033 ],
    "children" : [ 10346019, 10346026, 10346013 ]
  }, {
    "dbId" : 10361133,
    "stId" : "R-BTA-392045",
    "displayName" : "Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 59097 ],
    "parents" : [ ],
    "children" : [ 10361121, 10361131 ]
  }, {
    "dbId" : 10361131,
    "stId" : "R-BTA-392044",
    "displayName" : "pFAK:Grb2:Sos [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10361133 ],
    "children" : [ 10337681, 10337685, 10356185 ]
  }, {
    "dbId" : 10336744,
    "stId" : "R-BTA-109845",
    "displayName" : "p-T202, Y204 MAPK3 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10350309 ],
    "children" : [ 10336742 ]
  }, {
    "dbId" : 10346026,
    "stId" : "R-BTA-9647912",
    "displayName" : "S-Farn-Me-2xPalmS HRAS [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "G3MXH2",
    "standardIdentifier" : "uniprot:G3MXH2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10346031 ],
    "children" : [ ]
  }, {
    "dbId" : 10350245,
    "stId" : "R-BTA-198683",
    "displayName" : "phospho-p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 59107 ],
    "identifier" : "E1BN61",
    "standardIdentifier" : "uniprot:E1BN61",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10350309,
    "stId" : "R-BTA-198701",
    "displayName" : "p-T,Y MAPK dimers [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48898,
    "diagramIds" : [ 59108 ],
    "parents" : [ ],
    "children" : [ 10336744, 10350300 ]
  }, {
    "dbId" : 10361127,
    "stId" : "R-BTA-392047",
    "displayName" : "Grb2:pFAK bound to NCAM1:pFyn [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 59094 ],
    "parents" : [ ],
    "children" : [ 10361121, 10361125 ]
  }, {
    "dbId" : 10345252,
    "stId" : "R-BTA-112354",
    "displayName" : "phospho-p-T185,Y187-MAPK1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "P46196",
    "standardIdentifier" : "uniprot:P46196",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10350300 ],
    "children" : [ ]
  }, {
    "dbId" : 10361125,
    "stId" : "R-BTA-392043",
    "displayName" : "pFAK:Grb2 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10361127 ],
    "children" : [ 10337681, 10356185 ]
  }, {
    "dbId" : 10351142,
    "stId" : "R-BTA-111910",
    "displayName" : "phospho-CREB1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 59113 ],
    "identifier" : "Q0V7N6",
    "standardIdentifier" : "uniprot:Q0V7N6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CREB1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10336742,
    "stId" : "R-BTA-112359",
    "displayName" : "phospho-p-T202,Y204-MAPK3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1B8P9",
    "standardIdentifier" : "uniprot:E1B8P9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10336744 ],
    "children" : [ ]
  }, {
    "dbId" : 10361123,
    "stId" : "R-BTA-391848",
    "displayName" : "Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "diagramIds" : [ 59092 ],
    "parents" : [ ],
    "children" : [ 10361121, 10356185 ]
  }, {
    "dbId" : 10351139,
    "stId" : "R-BTA-52777",
    "displayName" : "CREB1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "diagramIds" : [ 59111 ],
    "identifier" : "Q0V7N6",
    "standardIdentifier" : "uniprot:Q0V7N6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CREB1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10346019,
    "stId" : "R-BTA-9647910",
    "displayName" : "NRAS [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "A5D7R9",
    "standardIdentifier" : "uniprot:A5D7R9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NRAS" ],
    "parents" : [ 10346031 ],
    "children" : [ ]
  }, {
    "dbId" : 29438,
    "stId" : "R-ALL-29438",
    "displayName" : "GTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 59099 ],
    "identifier" : "37565",
    "standardIdentifier" : "chebi:37565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10346033 ],
    "children" : [ ]
  }, {
    "dbId" : 10361121,
    "stId" : "R-BTA-391842",
    "displayName" : "NCAM1 complexed with pFyn-Y420 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48898,
    "parents" : [ 10361123, 10361127, 10361133 ],
    "children" : [ 10361109, 10361083, 10361119 ]
  }, {
    "dbId" : 10352930,
    "stId" : "R-BTA-201601",
    "displayName" : "SPTAN1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48898,
    "identifier" : "E1BFB0",
    "standardIdentifier" : "uniprot:E1BFB0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SPTAN1" ],
    "parents" : [ 10361089 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10361135,
    "stId" : "R-BTA-392053",
    "displayName" : "SOS binds Grb2 bound to pFAK:NCAM1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10361129 ],
    "following" : [ 10361138 ],
    "inputs" : [ 10361127, 10337685 ],
    "outputs" : [ 10361133 ],
    "efs" : [ ],
    "diagramIds" : [ 59095 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10351310,
    "stId" : "R-BTA-199935",
    "displayName" : "MSK1 activates CREB",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10350312 ],
    "inputs" : [ 29358, 10351139 ],
    "outputs" : [ 113582, 10351142 ],
    "catalysts" : [ 10350245 ],
    "efs" : [ ],
    "diagramIds" : [ 59109 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10350312,
    "stId" : "R-BTA-198756",
    "displayName" : "ERK1/2 phosphorylates MSK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10351310 ],
    "inputs" : [ 29358, 10350239 ],
    "outputs" : [ 113582, 10350245 ],
    "catalysts" : [ 10350309 ],
    "efs" : [ ],
    "diagramIds" : [ 59103 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10361129,
    "stId" : "R-BTA-392051",
    "displayName" : "Recruitment of Grb2 to pFAK:NCAM1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10361135 ],
    "inputs" : [ 10361123, 10337681 ],
    "outputs" : [ 10361127 ],
    "efs" : [ ],
    "diagramIds" : [ 59091 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10361138,
    "stId" : "R-BTA-392054",
    "displayName" : "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10361135 ],
    "inputs" : [ 29438, 10347614 ],
    "outputs" : [ 29420, 10346033 ],
    "catalysts" : [ 10361133 ],
    "efs" : [ ],
    "diagramIds" : [ 59098 ],
    "entityFunctionalStatus" : [ ]
  } ]
}