{ "dbId" : 10332003, "stableId" : "R-CFA-9909615", "displayName" : "Regulation of PD-L1(CD274) Post-translational modification", "nodes" : [ { "id" : 32775, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 451, "y" : 95 }, "minX" : 406, "maxX" : 498, "minY" : 79, "maxY" : 139, "prop" : { "x" : 406, "y" : 80, "width" : 91, "height" : 31 }, "textPosition" : { "x" : 436, "y" : 85 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 492, "y" : 85 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 492, "y" : 85 } } }, "connectors" : [ { "edgeId" : 32774, "type" : "INPUT", "segments" : [ { "from" : { "x" : 451, "y" : 114 }, "to" : { "x" : 452, "y" : 139 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32776, "reactomeId" : 10326730, "displayName" : "SPOP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 376, "y" : 138 }, "minX" : 332, "maxX" : 452, "minY" : 121, "maxY" : 150, "prop" : { "x" : 332, "y" : 127, "width" : 89, "height" : 23 }, "textPosition" : { "x" : 356, "y" : 128 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 421, "y" : 127 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 421, "y" : 127 } } }, "connectors" : [ { "edgeId" : 32774, "type" : "INPUT", "segments" : [ { "from" : { "x" : 424, "y" : 138 }, "to" : { "x" : 452, "y" : 139 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32777, "reactomeId" : 10326732, "displayName" : "SPOP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 638, "y" : 140 }, "minX" : 564, "maxX" : 689, "minY" : 116, "maxY" : 159, "prop" : { "x" : 593, "y" : 122, "width" : 90, "height" : 37 }, "textPosition" : { "x" : 617, "y" : 130 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 683, "y" : 122 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 683, "y" : 122 } } }, "connectors" : [ { "edgeId" : 32774, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 590, "y" : 139 }, "to" : { "x" : 564, "y" : 139 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 583, "y" : 143 }, "b" : { "x" : 590, "y" : 139 }, "c" : { "x" : 583, "y" : 135 }, "type" : "ARROW", "centre" : { "x" : 583, "y" : 135 } } } ] }, { "id" : 32778, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 560, "y" : 96 }, "minX" : 514, "maxX" : 607, "minY" : 80, "maxY" : 139, "prop" : { "x" : 514, "y" : 81, "width" : 92, "height" : 31 }, "textPosition" : { "x" : 543, "y" : 86 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 601, "y" : 86 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 601, "y" : 86 } } }, "connectors" : [ { "edgeId" : 32774, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 561, "y" : 115 }, "to" : { "x" : 564, "y" : 139 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 566, "y" : 121 }, "b" : { "x" : 561, "y" : 115 }, "c" : { "x" : 558, "y" : 122 }, "type" : "ARROW", "centre" : { "x" : 558, "y" : 122 } } } ] }, { "id" : 32779, "reactomeId" : 10306394, "displayName" : "CDK4:CCND1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 505, "y" : 52 }, "minX" : 461, "maxX" : 555, "minY" : 35, "maxY" : 131, "prop" : { "x" : 461, "y" : 41, "width" : 88, "height" : 23 }, "textPosition" : { "x" : 462, "y" : 43 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 549, "y" : 41 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 549, "y" : 41 } } }, "connectors" : [ { "edgeId" : 32774, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 505, "y" : 67 }, "to" : { "x" : 507, "y" : 123 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 507, "y" : 127 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 507, "y" : 127 } } } ] }, { "id" : 32781, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 614, "y" : 352 }, "minX" : 529, "maxX" : 640, "minY" : 336, "maxY" : 388, "prop" : { "x" : 589, "y" : 337, "width" : 50, "height" : 31 }, "textPosition" : { "x" : 598, "y" : 342 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 634, "y" : 342 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 634, "y" : 342 } } }, "connectors" : [ { "edgeId" : 32780, "type" : "INPUT", "segments" : [ { "from" : { "x" : 586, "y" : 362 }, "to" : { "x" : 529, "y" : 388 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32782, "reactomeId" : 10326707, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 440, "y" : 451 }, "minX" : 373, "maxX" : 529, "minY" : 388, "maxY" : 529, "prop" : { "x" : 373, "y" : 426, "width" : 135, "height" : 51 }, "textPosition" : { "x" : 416, "y" : 441 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 508, "y" : 426 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 508, "y" : 426 } } }, "connectors" : [ { "edgeId" : 32780, "type" : "INPUT", "segments" : [ { "from" : { "x" : 476, "y" : 423 }, "to" : { "x" : 529, "y" : 388 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32790, "type" : "INPUT", "segments" : [ { "from" : { "x" : 456, "y" : 480 }, "to" : { "x" : 491, "y" : 529 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32783, "reactomeId" : 10327001, "displayName" : "phospho-CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 667, "y" : 446 }, "minX" : 528, "maxX" : 741, "minY" : 387, "maxY" : 479, "prop" : { "x" : 600, "y" : 414, "width" : 135, "height" : 65 }, "textPosition" : { "x" : 613, "y" : 436 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 735, "y" : 414 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 735, "y" : 414 } } }, "connectors" : [ { "edgeId" : 32780, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 597, "y" : 417 }, "to" : { "x" : 528, "y" : 387 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 589, "y" : 418 }, "b" : { "x" : 597, "y" : 417 }, "c" : { "x" : 592, "y" : 411 }, "type" : "ARROW", "centre" : { "x" : 592, "y" : 411 } } } ] }, { "id" : 32784, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 443, "y" : 366 }, "minX" : 419, "maxX" : 528, "minY" : 350, "maxY" : 387, "prop" : { "x" : 419, "y" : 351, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 427, "y" : 355 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 463, "y" : 356 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 463, "y" : 356 } } }, "connectors" : [ { "edgeId" : 32780, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 471, "y" : 372 }, "to" : { "x" : 528, "y" : 387 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 479, "y" : 370 }, "b" : { "x" : 471, "y" : 372 }, "c" : { "x" : 477, "y" : 378 }, "type" : "ARROW", "centre" : { "x" : 477, "y" : 378 } } } ] }, { "id" : 32785, "reactomeId" : 10327003, "displayName" : "CK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 530, "y" : 320 }, "minX" : 488, "maxX" : 578, "minY" : 303, "maxY" : 378, "prop" : { "x" : 488, "y" : 309, "width" : 84, "height" : 23 }, "textPosition" : { "x" : 514, "y" : 311 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 572, "y" : 309 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 572, "y" : 309 } } }, "connectors" : [ { "edgeId" : 32780, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 529, "y" : 335 }, "to" : { "x" : 529, "y" : 370 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 529, "y" : 374 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 529, "y" : 374 } } } ] }, { "id" : 32787, "reactomeId" : 10226816, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 900, "y" : 224 }, "minX" : 862, "maxX" : 938, "minY" : 213, "maxY" : 261, "prop" : { "x" : 862, "y" : 213, "width" : 76, "height" : 23 }, "textPosition" : { "x" : 887, "y" : 214 }, "connectors" : [ { "edgeId" : 32786, "type" : "INPUT", "segments" : [ { "from" : { "x" : 906, "y" : 242 }, "to" : { "x" : 920, "y" : 261 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 907, "y" : 245 }, "b" : { "x" : 919, "y" : 257 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 913, "y" : 251 } } } } ] }, { "id" : 32788, "reactomeId" : 10326743, "displayName" : "SPOP:CUL3:RBX1:CD274", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 796, "y" : 288 }, "minX" : 737, "maxX" : 936, "minY" : 261, "maxY" : 311, "prop" : { "x" : 737, "y" : 270, "width" : 119, "height" : 37 }, "textPosition" : { "x" : 739, "y" : 272 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 856, "y" : 270 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 856, "y" : 270 } } }, "connectors" : [ { "edgeId" : 32786, "type" : "INPUT", "segments" : [ { "from" : { "x" : 859, "y" : 275 }, "to" : { "x" : 920, "y" : 261 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32786, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 859, "y" : 300 }, "to" : { "x" : 904, "y" : 311 } }, { "from" : { "x" : 904, "y" : 311 }, "to" : { "x" : 929, "y" : 291 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 932, "y" : 289 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 932, "y" : 289 } } } ] }, { "id" : 32789, "reactomeId" : 10326745, "displayName" : "polyUb-PDL1:SPOP:CUL3:RBX1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1155, "y" : 288 }, "minX" : 1096, "maxX" : 1221, "minY" : 257, "maxY" : 314, "prop" : { "x" : 1096, "y" : 263, "width" : 119, "height" : 51 }, "textPosition" : { "x" : 1100, "y" : 279 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1215, "y" : 263 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1215, "y" : 263 } } }, "connectors" : [ { "edgeId" : 32786, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32791, "reactomeId" : 8931885, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 538, "y" : 526 }, "minX" : 491, "maxX" : 563, "minY" : 506, "maxY" : 546, "prop" : { "x" : 514, "y" : 507, "width" : 48, "height" : 39 }, "textPosition" : { "x" : 522, "y" : 516 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 557, "y" : 512 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 557, "y" : 512 } } }, "connectors" : [ { "edgeId" : 32790, "type" : "INPUT", "segments" : [ { "from" : { "x" : 511, "y" : 527 }, "to" : { "x" : 491, "y" : 529 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32792, "reactomeId" : 10326688, "displayName" : "phospho-CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 337, "y" : 573 }, "minX" : 270, "maxX" : 930, "minY" : 535, "maxY" : 626, "prop" : { "x" : 270, "y" : 541, "width" : 135, "height" : 65 }, "textPosition" : { "x" : 283, "y" : 563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 405, "y" : 541 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 405, "y" : 541 } } }, "connectors" : [ { "edgeId" : 32832, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 408, "y" : 583 }, "to" : { "x" : 665, "y" : 626 } }, { "from" : { "x" : 665, "y" : 626 }, "to" : { "x" : 903, "y" : 618 } }, { "from" : { "x" : 903, "y" : 618 }, "to" : { "x" : 926, "y" : 560 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 922, "y" : 559 }, "b" : { "x" : 930, "y" : 561 }, "c" : { "x" : 926, "y" : 560 }, "type" : "STOP", "centre" : { "x" : 926, "y" : 560 } } }, { "edgeId" : 32790, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 408, "y" : 573 }, "to" : { "x" : 489, "y" : 575 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 415, "y" : 569 }, "b" : { "x" : 408, "y" : 573 }, "c" : { "x" : 415, "y" : 577 }, "type" : "ARROW", "centre" : { "x" : 415, "y" : 577 } } }, { "edgeId" : 32797, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32793, "reactomeId" : 8931884, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 499, "y" : 662 }, "minX" : 479, "maxX" : 521, "minY" : 575, "maxY" : 681, "prop" : { "x" : 479, "y" : 644, "width" : 41, "height" : 37 }, "textPosition" : { "x" : 483, "y" : 652 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 515, "y" : 649 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 515, "y" : 649 } } }, "connectors" : [ { "edgeId" : 32790, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 496, "y" : 641 }, "to" : { "x" : 489, "y" : 575 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 491, "y" : 635 }, "b" : { "x" : 496, "y" : 641 }, "c" : { "x" : 499, "y" : 634 }, "type" : "ARROW", "centre" : { "x" : 499, "y" : 634 } } } ] }, { "id" : 32794, "reactomeId" : 10326709, "displayName" : "GSK3B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 673, "y" : 579 }, "minX" : 496, "maxX" : 745, "minY" : 555, "maxY" : 598, "prop" : { "x" : 607, "y" : 561, "width" : 132, "height" : 37 }, "textPosition" : { "x" : 649, "y" : 569 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 739, "y" : 561 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 739, "y" : 561 } } }, "connectors" : [ { "edgeId" : 32790, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 604, "y" : 577 }, "to" : { "x" : 504, "y" : 574 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 500, "y" : 574 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 500, "y" : 574 } } } ] }, { "id" : 32795, "reactomeId" : 10326719, "displayName" : "phospho-CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 349, "y" : 666 }, "minX" : 282, "maxX" : 482, "minY" : 576, "maxY" : 699, "prop" : { "x" : 282, "y" : 634, "width" : 135, "height" : 65 }, "textPosition" : { "x" : 295, "y" : 656 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 417, "y" : 634 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 417, "y" : 634 } } }, "connectors" : [ { "edgeId" : 32809, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32790, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 398, "y" : 631 }, "to" : { "x" : 480, "y" : 579 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 478, "y" : 576 }, "b" : { "x" : 482, "y" : 582 }, "c" : { "x" : 480, "y" : 579 }, "type" : "STOP", "centre" : { "x" : 480, "y" : 579 } } } ] }, { "id" : 32796, "reactomeId" : 10326715, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 971, "y" : 449 }, "minX" : 496, "maxX" : 1045, "minY" : 411, "maxY" : 576, "prop" : { "x" : 904, "y" : 417, "width" : 135, "height" : 65 }, "textPosition" : { "x" : 947, "y" : 439 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1039, "y" : 417 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1039, "y" : 417 } } }, "connectors" : [ { "edgeId" : 32832, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32790, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 901, "y" : 470 }, "to" : { "x" : 706, "y" : 533 } }, { "from" : { "x" : 706, "y" : 533 }, "to" : { "x" : 497, "y" : 572 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 496, "y" : 568 }, "b" : { "x" : 498, "y" : 576 }, "c" : { "x" : 497, "y" : 572 }, "type" : "STOP", "centre" : { "x" : 497, "y" : 572 } } } ] }, { "id" : 32798, "reactomeId" : 10326703, "displayName" : "phospho-CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 249, "y" : 502 }, "minX" : 199, "maxX" : 306, "minY" : 456, "maxY" : 521, "prop" : { "x" : 199, "y" : 484, "width" : 101, "height" : 37 }, "textPosition" : { "x" : 216, "y" : 485 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 300, "y" : 484 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 300, "y" : 484 } } }, "connectors" : [ { "edgeId" : 32797, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32799, "type" : "INPUT", "segments" : [ { "from" : { "x" : 236, "y" : 481 }, "to" : { "x" : 219, "y" : 456 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32800, "reactomeId" : 10246813, "displayName" : "BTRC:CUL1:RBX1:SKP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 118, "y" : 463 }, "minX" : 62, "maxX" : 320, "minY" : 314, "maxY" : 483, "prop" : { "x" : 62, "y" : 444, "width" : 113, "height" : 39 }, "textPosition" : { "x" : 62, "y" : 448 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 175, "y" : 444 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 175, "y" : 444 } } }, "connectors" : [ { "edgeId" : 32802, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 178, "y" : 451 }, "to" : { "x" : 270, "y" : 432 } }, { "from" : { "x" : 270, "y" : 432 }, "to" : { "x" : 315, "y" : 322 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 316, "y" : 318 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 316, "y" : 318 } } }, { "edgeId" : 32807, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 107, "y" : 441 }, "to" : { "x" : 64, "y" : 360 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 100, "y" : 437 }, "b" : { "x" : 107, "y" : 441 }, "c" : { "x" : 107, "y" : 433 }, "type" : "ARROW", "centre" : { "x" : 107, "y" : 433 } } }, { "edgeId" : 32799, "type" : "INPUT", "segments" : [ { "from" : { "x" : 178, "y" : 459 }, "to" : { "x" : 219, "y" : 456 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32801, "reactomeId" : 10326690, "displayName" : "p-S184,T180-CD274:BTRC E3 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 215, "y" : 348 }, "minX" : 108, "maxX" : 287, "minY" : 277, "maxY" : 374, "prop" : { "x" : 161, "y" : 323, "width" : 109, "height" : 51 }, "textPosition" : { "x" : 161, "y" : 325 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 270, "y" : 323 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 270, "y" : 323 } } }, "connectors" : [ { "edgeId" : 32802, "type" : "INPUT", "segments" : [ { "from" : { "x" : 263, "y" : 320 }, "to" : { "x" : 287, "y" : 310 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32805, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 176, "y" : 320 }, "to" : { "x" : 108, "y" : 277 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 168, "y" : 320 }, "b" : { "x" : 176, "y" : 320 }, "c" : { "x" : 172, "y" : 313 }, "type" : "ARROW", "centre" : { "x" : 172, "y" : 313 } } }, { "edgeId" : 32799, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32803, "reactomeId" : 10226816, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 209, "y" : 261 }, "minX" : 64, "maxX" : 287, "minY" : 250, "maxY" : 360, "prop" : { "x" : 171, "y" : 250, "width" : 76, "height" : 23 }, "textPosition" : { "x" : 196, "y" : 251 }, "connectors" : [ { "edgeId" : 32802, "type" : "INPUT", "segments" : [ { "from" : { "x" : 227, "y" : 279 }, "to" : { "x" : 287, "y" : 310 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 251, "y" : 288 }, "b" : { "x" : 263, "y" : 300 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 257, "y" : 294 } } } }, { "edgeId" : 32805, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 165, "y" : 267 }, "to" : { "x" : 108, "y" : 277 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 159, "y" : 272 }, "b" : { "x" : 165, "y" : 267 }, "c" : { "x" : 157, "y" : 264 }, "type" : "ARROW", "centre" : { "x" : 157, "y" : 264 } } }, { "edgeId" : 32807, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 192, "y" : 279 }, "to" : { "x" : 64, "y" : 360 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 122, "y" : 313 }, "b" : { "x" : 134, "y" : 325 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 128, "y" : 319 } } }, "endShape" : { "a" : { "x" : 188, "y" : 286 }, "b" : { "x" : 192, "y" : 279 }, "c" : { "x" : 184, "y" : 279 }, "type" : "ARROW", "centre" : { "x" : 184, "y" : 279 } } } ] }, { "id" : 32804, "reactomeId" : 10326692, "displayName" : "polyUb-p184,T189-CD274:BTRC E3 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 199, "y" : 175 }, "minX" : 135, "maxX" : 269, "minY" : 144, "maxY" : 201, "prop" : { "x" : 135, "y" : 150, "width" : 128, "height" : 51 }, "textPosition" : { "x" : 136, "y" : 152 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 263, "y" : 150 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 263, "y" : 150 } } }, "connectors" : [ { "edgeId" : 32802, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32805, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32807, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32806, "reactomeId" : 10326698, "displayName" : "COPS5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 72, "y" : 222 }, "minX" : 27, "maxX" : 124, "minY" : 205, "maxY" : 270, "prop" : { "x" : 27, "y" : 211, "width" : 91, "height" : 23 }, "textPosition" : { "x" : 48, "y" : 212 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 118, "y" : 211 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 118, "y" : 211 } } }, "connectors" : [ { "edgeId" : 32805, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 79, "y" : 237 }, "to" : { "x" : 98, "y" : 263 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 101, "y" : 266 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 101, "y" : 266 } } } ] }, { "id" : 32808, "reactomeId" : 10226918, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 463, "y" : 189 }, "minX" : 349, "maxX" : 523, "minY" : 163, "maxY" : 209, "prop" : { "x" : 410, "y" : 169, "width" : 107, "height" : 40 }, "textPosition" : { "x" : 421, "y" : 174 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 517, "y" : 169 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 517, "y" : 169 } } }, "connectors" : [ { "edgeId" : 32807, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 407, "y" : 182 }, "to" : { "x" : 357, "y" : 176 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 353, "y" : 175 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 353, "y" : 175 } } } ] }, { "id" : 32810, "reactomeId" : 10326707, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 346, "y" : 811 }, "minX" : 279, "maxX" : 420, "minY" : 780, "maxY" : 871, "prop" : { "x" : 279, "y" : 786, "width" : 135, "height" : 51 }, "textPosition" : { "x" : 322, "y" : 801 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 414, "y" : 786 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 414, "y" : 786 } } }, "connectors" : [ { "edgeId" : 32809, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32812, "type" : "INPUT", "segments" : [ { "from" : { "x" : 345, "y" : 840 }, "to" : { "x" : 344, "y" : 871 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32811, "reactomeId" : 10326994, "displayName" : "NEK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 463, "y" : 744 }, "minX" : 352, "maxX" : 532, "minY" : 720, "maxY" : 763, "prop" : { "x" : 400, "y" : 726, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 443, "y" : 734 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 526, "y" : 726 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 526, "y" : 726 } } }, "connectors" : [ { "edgeId" : 32809, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 397, "y" : 742 }, "to" : { "x" : 360, "y" : 742 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 356, "y" : 742 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 356, "y" : 742 } } } ] }, { "id" : 32813, "reactomeId" : 8931885, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 468, "y" : 820 }, "minX" : 344, "maxX" : 488, "minY" : 803, "maxY" : 871, "prop" : { "x" : 449, "y" : 804, "width" : 38, "height" : 33 }, "textPosition" : { "x" : 452, "y" : 810 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 482, "y" : 809 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 482, "y" : 809 } } }, "connectors" : [ { "edgeId" : 32812, "type" : "INPUT", "segments" : [ { "from" : { "x" : 446, "y" : 827 }, "to" : { "x" : 344, "y" : 871 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32814, "reactomeId" : 10326880, "displayName" : "phospho-CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 448, "y" : 977 }, "minX" : 346, "maxX" : 664, "minY" : 914, "maxY" : 1010, "prop" : { "x" : 395, "y" : 945, "width" : 106, "height" : 65 }, "textPosition" : { "x" : 414, "y" : 960 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 501, "y" : 945 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 501, "y" : 945 } } }, "connectors" : [ { "edgeId" : 32812, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 395, "y" : 942 }, "to" : { "x" : 346, "y" : 914 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 387, "y" : 942 }, "b" : { "x" : 395, "y" : 942 }, "c" : { "x" : 391, "y" : 935 }, "type" : "ARROW", "centre" : { "x" : 391, "y" : 935 } } }, { "edgeId" : 32817, "type" : "INPUT", "segments" : [ { "from" : { "x" : 497, "y" : 942 }, "to" : { "x" : 536, "y" : 919 } }, { "from" : { "x" : 536, "y" : 919 }, "to" : { "x" : 664, "y" : 914 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32815, "reactomeId" : 8931884, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 436, "y" : 896 }, "minX" : 346, "maxX" : 458, "minY" : 878, "maxY" : 914, "prop" : { "x" : 416, "y" : 879, "width" : 41, "height" : 35 }, "textPosition" : { "x" : 420, "y" : 886 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 452, "y" : 884 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 452, "y" : 884 } } }, "connectors" : [ { "edgeId" : 32812, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 413, "y" : 900 }, "to" : { "x" : 346, "y" : 914 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 407, "y" : 905 }, "b" : { "x" : 413, "y" : 900 }, "c" : { "x" : 405, "y" : 898 }, "type" : "ARROW", "centre" : { "x" : 405, "y" : 898 } } } ] }, { "id" : 32816, "reactomeId" : 10326977, "displayName" : "p-AMPK heterotrimer:AMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 634, "y" : 864 }, "minX" : 353, "maxX" : 697, "minY" : 838, "maxY" : 895, "prop" : { "x" : 577, "y" : 844, "width" : 114, "height" : 41 }, "textPosition" : { "x" : 588, "y" : 836 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 691, "y" : 844 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 691, "y" : 844 } } }, "connectors" : [ { "edgeId" : 32812, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 574, "y" : 865 }, "to" : { "x" : 361, "y" : 890 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 357, "y" : 891 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 357, "y" : 891 } } } ] }, { "id" : 32818, "reactomeId" : 10309273, "displayName" : "ERAD complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 591, "y" : 972 }, "minX" : 542, "maxX" : 1099, "minY" : 882, "maxY" : 1005, "prop" : { "x" : 542, "y" : 940, "width" : 98, "height" : 65 }, "textPosition" : { "x" : 543, "y" : 984 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 640, "y" : 940 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 640, "y" : 940 } } }, "connectors" : [ { "edgeId" : 32817, "type" : "INPUT", "segments" : [ { "from" : { "x" : 631, "y" : 937 }, "to" : { "x" : 664, "y" : 914 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32823, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 643, "y" : 943 }, "to" : { "x" : 745, "y" : 882 } }, { "from" : { "x" : 745, "y" : 882 }, "to" : { "x" : 1099, "y" : 890 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 647, "y" : 936 }, "b" : { "x" : 643, "y" : 943 }, "c" : { "x" : 651, "y" : 943 }, "type" : "ARROW", "centre" : { "x" : 651, "y" : 943 } } } ] }, { "id" : 32819, "reactomeId" : 10326882, "displayName" : "p-S195-CD274:ERAD complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 750, "y" : 977 }, "minX" : 696, "maxX" : 889, "minY" : 904, "maxY" : 1003, "prop" : { "x" : 696, "y" : 952, "width" : 109, "height" : 51 }, "textPosition" : { "x" : 700, "y" : 968 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 805, "y" : 952 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 805, "y" : 952 } } }, "connectors" : [ { "edgeId" : 32817, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32820, "type" : "INPUT", "segments" : [ { "from" : { "x" : 797, "y" : 949 }, "to" : { "x" : 843, "y" : 927 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32820, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 750, "y" : 949 }, "to" : { "x" : 750, "y" : 909 } }, { "from" : { "x" : 750, "y" : 909 }, "to" : { "x" : 881, "y" : 908 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 885, "y" : 908 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 885, "y" : 908 } } } ] }, { "id" : 32821, "reactomeId" : 10326912, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 876, "y" : 972 }, "minX" : 821, "maxX" : 931, "minY" : 927, "maxY" : 998, "prop" : { "x" : 821, "y" : 947, "width" : 110, "height" : 51 }, "textPosition" : { "x" : 863, "y" : 962 }, "connectors" : [ { "edgeId" : 32820, "type" : "INPUT", "segments" : [ { "from" : { "x" : 857, "y" : 941 }, "to" : { "x" : 843, "y" : 927 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32822, "reactomeId" : 10326914, "displayName" : "Poly-Ub-p-S195-CD274:ERAD complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1028, "y" : 959 }, "minX" : 971, "maxX" : 1103, "minY" : 891, "maxY" : 1006, "prop" : { "x" : 971, "y" : 913, "width" : 114, "height" : 93 }, "textPosition" : { "x" : 975, "y" : 957 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1085, "y" : 913 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1085, "y" : 913 } } }, "connectors" : [ { "edgeId" : 32820, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32823, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1079, "y" : 910 }, "to" : { "x" : 1103, "y" : 891 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32824, "reactomeId" : 8931885, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 966, "y" : 789 }, "minX" : 935, "maxX" : 1242, "minY" : 624, "maxY" : 891, "prop" : { "x" : 935, "y" : 776, "width" : 63, "height" : 27 }, "textPosition" : { "x" : 951, "y" : 779 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 993, "y" : 781 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 993, "y" : 781 } } }, "connectors" : [ { "edgeId" : 32837, "type" : "INPUT", "segments" : [ { "from" : { "x" : 988, "y" : 773 }, "to" : { "x" : 1242, "y" : 624 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32823, "type" : "INPUT", "segments" : [ { "from" : { "x" : 984, "y" : 806 }, "to" : { "x" : 1103, "y" : 891 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32825, "reactomeId" : 113519, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 916, "y" : 845 }, "minX" : 892, "maxX" : 1103, "minY" : 825, "maxY" : 891, "prop" : { "x" : 892, "y" : 826, "width" : 48, "height" : 39 }, "textPosition" : { "x" : 899, "y" : 835 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 935, "y" : 831 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 935, "y" : 831 } } }, "connectors" : [ { "edgeId" : 32823, "type" : "INPUT", "segments" : [ { "from" : { "x" : 943, "y" : 850 }, "to" : { "x" : 1103, "y" : 891 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 32826, "reactomeId" : 113551, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1129, "y" : 839 }, "minX" : 1099, "maxX" : 1159, "minY" : 817, "maxY" : 890, "prop" : { "x" : 1101, "y" : 818, "width" : 57, "height" : 42 }, "textPosition" : { "x" : 1120, "y" : 828 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1153, "y" : 823 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1153, "y" : 823 } } }, "connectors" : [ { "edgeId" : 32823, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1116, "y" : 863 }, "to" : { "x" : 1099, "y" : 890 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1116, "y" : 871 }, "b" : { "x" : 1116, "y" : 863 }, "c" : { "x" : 1109, "y" : 867 }, "type" : "ARROW", "centre" : { "x" : 1109, "y" : 867 } } } ] }, { "id" : 32827, "reactomeId" : 8931884, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1065, "y" : 799 }, "minX" : 1036, "maxX" : 1242, "minY" : 680, "maxY" : 890, "prop" : { "x" : 1036, "y" : 777, "width" : 58, "height" : 44 }, "textPosition" : { "x" : 1048, "y" : 788 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1089, "y" : 782 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1089, "y" : 782 } } }, "connectors" : [ { "edgeId" : 32837, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1097, "y" : 779 }, "to" : { "x" : 1242, "y" : 680 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1100, "y" : 772 }, "b" : { "x" : 1097, "y" : 779 }, "c" : { "x" : 1105, "y" : 778 }, "type" : "ARROW", "centre" : { "x" : 1105, "y" : 778 } } }, { "edgeId" : 32823, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1073, "y" : 824 }, "to" : { "x" : 1099, "y" : 890 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1079, "y" : 829 }, "b" : { "x" : 1073, "y" : 824 }, "c" : { "x" : 1072, "y" : 832 }, "type" : "ARROW", "centre" : { "x" : 1072, "y" : 832 } } } ] }, { "id" : 32828, "reactomeId" : 10326918, "displayName" : "polyUb-p-S195-CD274", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1361, "y" : 988 }, "minX" : 1099, "maxX" : 1424, "minY" : 890, "maxY" : 1007, "prop" : { "x" : 1304, "y" : 970, "width" : 114, "height" : 37 }, "textPosition" : { "x" : 1310, "y" : 972 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1418, "y" : 970 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1418, "y" : 970 } } }, "connectors" : [ { "edgeId" : 32823, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1311, "y" : 967 }, "to" : { "x" : 1099, "y" : 890 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1303, "y" : 968 }, "b" : { "x" : 1311, "y" : 967 }, "c" : { "x" : 1306, "y" : 961 }, "type" : "ARROW", "centre" : { "x" : 1306, "y" : 961 } } }, { "edgeId" : 32829, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32830, "reactomeId" : 10226816, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1623, "y" : 987 }, "minX" : 1585, "maxX" : 1661, "minY" : 976, "maxY" : 999, "prop" : { "x" : 1585, "y" : 976, "width" : 76, "height" : 23 }, "textPosition" : { "x" : 1610, "y" : 977 }, "connectors" : [ { "edgeId" : 32829, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32831, "reactomeId" : 10226918, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1488, "y" : 942 }, "minX" : 1434, "maxX" : 1548, "minY" : 923, "maxY" : 978, "prop" : { "x" : 1434, "y" : 929, "width" : 108, "height" : 26 }, "textPosition" : { "x" : 1446, "y" : 920 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1542, "y" : 929 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1542, "y" : 929 } } }, "connectors" : [ { "edgeId" : 32829, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1488, "y" : 958 }, "to" : { "x" : 1488, "y" : 970 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1488, "y" : 974 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1488, "y" : 974 } } } ] }, { "id" : 32833, "reactomeId" : 449651, "displayName" : "(Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1162, "y" : 486 }, "minX" : 1077, "maxX" : 1224, "minY" : 435, "maxY" : 552, "prop" : { "x" : 1102, "y" : 436, "width" : 121, "height" : 101 }, "textPosition" : { "x" : 1105, "y" : 469 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1218, "y" : 441 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1218, "y" : 441 } } }, "connectors" : [ { "edgeId" : 32832, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1099, "y" : 532 }, "to" : { "x" : 1077, "y" : 552 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32834, "reactomeId" : 10326707, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1243, "y" : 576 }, "minX" : 1077, "maxX" : 1317, "minY" : 545, "maxY" : 624, "prop" : { "x" : 1176, "y" : 551, "width" : 135, "height" : 51 }, "textPosition" : { "x" : 1219, "y" : 566 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1311, "y" : 551 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1311, "y" : 551 } } }, "connectors" : [ { "edgeId" : 32832, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1173, "y" : 566 }, "to" : { "x" : 1077, "y" : 552 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32837, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1242, "y" : 605 }, "to" : { "x" : 1242, "y" : 624 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32835, "reactomeId" : 10326936, "displayName" : "OST complex", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 830, "y" : 558 }, "minX" : 785, "maxX" : 921, "minY" : 526, "maxY" : 591, "prop" : { "x" : 785, "y" : 526, "width" : 90, "height" : 65 }, "textPosition" : { "x" : 786, "y" : 548 }, "connectors" : [ { "edgeId" : 32832, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 881, "y" : 555 }, "to" : { "x" : 913, "y" : 553 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 917, "y" : 553 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 917, "y" : 553 } } } ] }, { "id" : 32836, "reactomeId" : 10326940, "displayName" : "phospho-CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1245, "y" : 771 }, "minX" : 936, "maxX" : 1305, "minY" : 557, "maxY" : 804, "prop" : { "x" : 1192, "y" : 739, "width" : 107, "height" : 65 }, "textPosition" : { "x" : 1212, "y" : 754 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1299, "y" : 739 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1299, "y" : 739 } } }, "connectors" : [ { "edgeId" : 32832, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1198, "y" : 736 }, "to" : { "x" : 936, "y" : 557 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 944, "y" : 558 }, "b" : { "x" : 936, "y" : 557 }, "c" : { "x" : 939, "y" : 564 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 939, "y" : 564 } } }, { "edgeId" : 32837, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1243, "y" : 736 }, "to" : { "x" : 1242, "y" : 680 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1239, "y" : 729 }, "b" : { "x" : 1243, "y" : 736 }, "c" : { "x" : 1247, "y" : 729 }, "type" : "ARROW", "centre" : { "x" : 1247, "y" : 729 } } } ] }, { "id" : 32838, "reactomeId" : 10326954, "displayName" : "phospho-JAK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 990, "y" : 655 }, "minX" : 938, "maxX" : 1234, "minY" : 624, "maxY" : 681, "prop" : { "x" : 938, "y" : 630, "width" : 105, "height" : 51 }, "textPosition" : { "x" : 944, "y" : 645 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1043, "y" : 630 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1043, "y" : 630 } } }, "connectors" : [ { "edgeId" : 32837, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1046, "y" : 654 }, "to" : { "x" : 1226, "y" : 654 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1230, "y" : 654 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1230, "y" : 654 } } } ] }, { "id" : 32840, "reactomeId" : 10326715, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1249, "y" : 863 }, "minX" : 1182, "maxX" : 1323, "minY" : 825, "maxY" : 896, "prop" : { "x" : 1182, "y" : 831, "width" : 135, "height" : 65 }, "textPosition" : { "x" : 1225, "y" : 853 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1317, "y" : 831 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1317, "y" : 831 } } }, "connectors" : [ { "edgeId" : 32839, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32841, "reactomeId" : 10326875, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1435, "y" : 652 }, "minX" : 1386, "maxX" : 1535, "minY" : 621, "maxY" : 678, "prop" : { "x" : 1386, "y" : 627, "width" : 99, "height" : 51 }, "textPosition" : { "x" : 1411, "y" : 642 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1485, "y" : 627 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1485, "y" : 627 } } }, "connectors" : [ { "edgeId" : 32839, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1488, "y" : 637 }, "to" : { "x" : 1535, "y" : 622 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32843, "reactomeId" : 914003, "displayName" : "UDP-GlcNAc", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1557, "y" : 714 }, "minX" : 1492, "maxX" : 1623, "minY" : 622, "maxY" : 737, "prop" : { "x" : 1492, "y" : 692, "width" : 130, "height" : 45 }, "textPosition" : { "x" : 1516, "y" : 704 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1617, "y" : 697 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1617, "y" : 697 } } }, "connectors" : [ { "edgeId" : 32842, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1551, "y" : 689 }, "to" : { "x" : 1535, "y" : 622 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32844, "reactomeId" : 10326982, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1822, "y" : 570 }, "minX" : 1662, "maxX" : 1893, "minY" : 539, "maxY" : 689, "prop" : { "x" : 1757, "y" : 545, "width" : 130, "height" : 51 }, "textPosition" : { "x" : 1797, "y" : 560 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1887, "y" : 545 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1887, "y" : 545 } } }, "connectors" : [ { "edgeId" : 32842, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1754, "y" : 568 }, "to" : { "x" : 1662, "y" : 566 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1747, "y" : 572 }, "b" : { "x" : 1754, "y" : 568 }, "c" : { "x" : 1747, "y" : 564 }, "type" : "ARROW", "centre" : { "x" : 1747, "y" : 564 } } }, { "edgeId" : 32847, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1821, "y" : 599 }, "to" : { "x" : 1819, "y" : 689 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32845, "reactomeId" : 205687, "displayName" : "UDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1663, "y" : 630 }, "minX" : 1603, "maxX" : 1725, "minY" : 566, "maxY" : 646, "prop" : { "x" : 1603, "y" : 615, "width" : 121, "height" : 31 }, "textPosition" : { "x" : 1646, "y" : 620 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1719, "y" : 620 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1719, "y" : 620 } } }, "connectors" : [ { "edgeId" : 32842, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1662, "y" : 612 }, "to" : { "x" : 1662, "y" : 566 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1658, "y" : 605 }, "b" : { "x" : 1662, "y" : 612 }, "c" : { "x" : 1666, "y" : 605 }, "type" : "ARROW", "centre" : { "x" : 1666, "y" : 605 } } } ] }, { "id" : 32846, "reactomeId" : 10261767, "displayName" : "B3GNT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1451, "y" : 566 }, "minX" : 1402, "maxX" : 1559, "minY" : 542, "maxY" : 585, "prop" : { "x" : 1402, "y" : 548, "width" : 99, "height" : 37 }, "textPosition" : { "x" : 1423, "y" : 556 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1501, "y" : 548 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1501, "y" : 548 } } }, "connectors" : [ { "edgeId" : 32842, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1504, "y" : 566 }, "to" : { "x" : 1551, "y" : 567 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1555, "y" : 568 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1555, "y" : 568 } } } ] }, { "id" : 32848, "reactomeId" : 10238454, "displayName" : "K63polyUb", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 1697, "y" : 689 }, "minX" : 1635, "maxX" : 1819, "minY" : 678, "maxY" : 701, "prop" : { "x" : 1635, "y" : 678, "width" : 124, "height" : 23 }, "textPosition" : { "x" : 1660, "y" : 679 }, "connectors" : [ { "edgeId" : 32847, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1762, "y" : 689 }, "to" : { "x" : 1819, "y" : 689 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32849, "reactomeId" : 10326947, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1821, "y" : 798 }, "minX" : 1756, "maxX" : 1892, "minY" : 760, "maxY" : 831, "prop" : { "x" : 1756, "y" : 766, "width" : 130, "height" : 65 }, "textPosition" : { "x" : 1796, "y" : 788 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1886, "y" : 766 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1886, "y" : 766 } } }, "connectors" : [ { "edgeId" : 32847, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 32851, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32850, "reactomeId" : 10327010, "displayName" : "MIB2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1712, "y" : 731 }, "minX" : 1673, "maxX" : 1811, "minY" : 707, "maxY" : 750, "prop" : { "x" : 1673, "y" : 713, "width" : 78, "height" : 37 }, "textPosition" : { "x" : 1693, "y" : 721 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1751, "y" : 713 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1751, "y" : 713 } } }, "connectors" : [ { "edgeId" : 32847, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1754, "y" : 729 }, "to" : { "x" : 1803, "y" : 727 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1807, "y" : 727 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1807, "y" : 727 } } } ] }, { "id" : 32852, "reactomeId" : 10326950, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1934, "y" : 235 }, "minX" : 1861, "maxX" : 2014, "minY" : 195, "maxY" : 270, "prop" : { "x" : 1861, "y" : 201, "width" : 147, "height" : 69 }, "textPosition" : { "x" : 1910, "y" : 225 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2008, "y" : 201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2008, "y" : 201 } } }, "connectors" : [ { "edgeId" : 32851, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32854, "reactomeId" : 10252737, "displayName" : "PDCD1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1478, "y" : 28 }, "minX" : 1426, "maxX" : 1754, "minY" : 4, "maxY" : 74, "prop" : { "x" : 1426, "y" : 10, "width" : 104, "height" : 37 }, "textPosition" : { "x" : 1453, "y" : 18 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1530, "y" : 10 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1530, "y" : 10 } } }, "connectors" : [ { "edgeId" : 32853, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1533, "y" : 36 }, "to" : { "x" : 1754, "y" : 74 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32855, "reactomeId" : 10327513, "displayName" : "PD-L1,PD-L2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1671, "y" : 24 }, "minX" : 1608, "maxX" : 1754, "minY" : 6, "maxY" : 74, "prop" : { "x" : 1608, "y" : 6, "width" : 126, "height" : 37 }, "textPosition" : { "x" : 1630, "y" : 14 }, "connectors" : [ { "edgeId" : 32853, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1701, "y" : 49 }, "to" : { "x" : 1754, "y" : 74 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32856, "reactomeId" : 10327515, "displayName" : "PDCD1:PD-L1,PD-L2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1939, "y" : 119 }, "minX" : 1870, "maxX" : 2014, "minY" : 100, "maxY" : 132, "prop" : { "x" : 1870, "y" : 106, "width" : 138, "height" : 26 }, "textPosition" : { "x" : 1875, "y" : 111 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2008, "y" : 106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2008, "y" : 106 } } }, "connectors" : [ { "edgeId" : 32853, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 32857, "reactomeId" : 10252751, "displayName" : "PDCD1:PDCD1 inhibitors", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1889, "y" : 31 }, "minX" : 1760, "maxX" : 1953, "minY" : 0, "maxY" : 75, "prop" : { "x" : 1831, "y" : 6, "width" : 116, "height" : 51 }, "textPosition" : { "x" : 1839, "y" : 22 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1947, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1947, "y" : 6 } } }, "connectors" : [ { "edgeId" : 32853, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1828, "y" : 49 }, "to" : { "x" : 1761, "y" : 71 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1760, "y" : 67 }, "b" : { "x" : 1762, "y" : 75 }, "c" : { "x" : 1761, "y" : 71 }, "type" : "STOP", "centre" : { "x" : 1761, "y" : 71 } } } ] }, { "id" : 32863, "reactomeId" : 10330141, "displayName" : "Co-inhibition by PD-1", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1616, "y" : 233 }, "minX" : 1517, "maxX" : 1716, "minY" : 196, "maxY" : 270, "prop" : { "x" : 1517, "y" : 196, "width" : 199, "height" : 74 }, "textPosition" : { "x" : 1544, "y" : 218 }, "connectors" : [ ] } ], "edges" : [ { "id" : 32832, "reactomeId" : 10326942, "displayName" : "CD274 N-linked glycosylation in ER", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 929, "y" : 552 }, "minX" : 923, "maxX" : 1077, "minY" : 485, "maxY" : 558, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1077, "y" : 552 }, "to" : { "x" : 929, "y" : 552 } }, { "from" : { "x" : 929, "y" : 552 }, "to" : { "x" : 957, "y" : 485 } } ], "endShape" : { "a" : { "x" : 958, "y" : 493 }, "b" : { "x" : 957, "y" : 485 }, "c" : { "x" : 951, "y" : 490 }, "type" : "ARROW", "centre" : { "x" : 951, "y" : 490 } }, "reactionShape" : { "a" : { "x" : 923, "y" : 546 }, "b" : { "x" : 935, "y" : 558 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 929, "y" : 552 } }, "inputs" : [ { "id" : 32833, "points" : [ { "x" : 1099, "y" : 532 } ] }, { "id" : 32834, "points" : [ { "x" : 1173, "y" : 566 } ] } ], "outputs" : [ { "id" : 32796 } ], "catalysts" : [ { "id" : 32835, "points" : [ { "x" : 881, "y" : 555 } ] } ], "inhibitors" : [ { "id" : 32792, "points" : [ { "x" : 408, "y" : 583 }, { "x" : 665, "y" : 626 }, { "x" : 903, "y" : 618 } ] } ], "activators" : [ { "id" : 32836, "points" : [ { "x" : 1198, "y" : 736 } ] } ] }, { "id" : 32802, "reactomeId" : 10326694, "displayName" : "Ubiquitination of CD274 by BTRC-SCF E3-ligase complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 321, "y" : 307 }, "minX" : 222, "maxX" : 327, "minY" : 204, "maxY" : 313, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 287, "y" : 310 }, "to" : { "x" : 321, "y" : 307 } }, { "from" : { "x" : 321, "y" : 307 }, "to" : { "x" : 222, "y" : 204 } } ], "endShape" : { "a" : { "x" : 230, "y" : 206 }, "b" : { "x" : 222, "y" : 204 }, "c" : { "x" : 224, "y" : 212 }, "type" : "ARROW", "centre" : { "x" : 224, "y" : 212 } }, "reactionShape" : { "a" : { "x" : 315, "y" : 301 }, "b" : { "x" : 327, "y" : 313 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 321, "y" : 307 } }, "inputs" : [ { "id" : 32801, "points" : [ { "x" : 263, "y" : 320 } ] }, { "id" : 32803, "points" : [ { "x" : 227, "y" : 279 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 32804 } ], "catalysts" : [ { "id" : 32800, "points" : [ { "x" : 178, "y" : 451 }, { "x" : 270, "y" : 432 } ] } ] }, { "id" : 32837, "reactomeId" : 10326957, "displayName" : "IL6-activated JAK1 phosphorylates CD274", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1242, "y" : 654 }, "minX" : 1236, "maxX" : 1248, "minY" : 624, "maxY" : 680, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1242, "y" : 624 }, "to" : { "x" : 1242, "y" : 654 } }, { "from" : { "x" : 1242, "y" : 654 }, "to" : { "x" : 1242, "y" : 680 } } ], "reactionShape" : { "a" : { "x" : 1236, "y" : 648 }, "b" : { "x" : 1248, "y" : 660 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1242, "y" : 654 } }, "inputs" : [ { "id" : 32834, "points" : [ { "x" : 1242, "y" : 605 } ] }, { "id" : 32824, "points" : [ { "x" : 988, "y" : 773 } ] } ], "outputs" : [ { "id" : 32836, "points" : [ { "x" : 1243, "y" : 736 } ] }, { "id" : 32827, "points" : [ { "x" : 1097, "y" : 779 } ] } ], "catalysts" : [ { "id" : 32838, "points" : [ { "x" : 1046, "y" : 654 } ] } ] }, { "id" : 32805, "reactomeId" : 10326701, "displayName" : "Deubiquitination of CD274", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 108, "y" : 276 }, "minX" : 102, "maxX" : 176, "minY" : 204, "maxY" : 282, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 176, "y" : 204 }, "to" : { "x" : 108, "y" : 276 } }, { "from" : { "x" : 108, "y" : 276 }, "to" : { "x" : 108, "y" : 277 } } ], "reactionShape" : { "a" : { "x" : 102, "y" : 270 }, "b" : { "x" : 114, "y" : 282 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 108, "y" : 276 } }, "inputs" : [ { "id" : 32804 } ], "outputs" : [ { "id" : 32801, "points" : [ { "x" : 176, "y" : 320 } ] }, { "id" : 32803, "points" : [ { "x" : 165, "y" : 267 } ] } ], "catalysts" : [ { "id" : 32806, "points" : [ { "x" : 79, "y" : 237 } ] } ] }, { "id" : 32774, "reactomeId" : 10326735, "displayName" : "CDK4:CCND1 phosphorylates SPOP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 507, "y" : 139 }, "minX" : 452, "maxX" : 564, "minY" : 133, "maxY" : 145, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 452, "y" : 139 }, "to" : { "x" : 507, "y" : 139 } }, { "from" : { "x" : 507, "y" : 139 }, "to" : { "x" : 564, "y" : 139 } } ], "reactionShape" : { "a" : { "x" : 501, "y" : 133 }, "b" : { "x" : 513, "y" : 145 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 507, "y" : 139 } }, "inputs" : [ { "id" : 32775, "points" : [ { "x" : 451, "y" : 114 } ] }, { "id" : 32776, "points" : [ { "x" : 424, "y" : 138 } ] } ], "outputs" : [ { "id" : 32777, "points" : [ { "x" : 590, "y" : 139 } ] }, { "id" : 32778, "points" : [ { "x" : 561, "y" : 115 } ] } ], "catalysts" : [ { "id" : 32779, "points" : [ { "x" : 505, "y" : 67 } ] } ] }, { "id" : 32839, "reactomeId" : 10326877, "displayName" : "Transport of N-glycosylated CD274 to Golgi", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1347, "y" : 797 }, "minX" : 1297, "maxX" : 1419, "minY" : 681, "maxY" : 828, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1297, "y" : 828 }, "to" : { "x" : 1347, "y" : 797 } }, { "from" : { "x" : 1347, "y" : 797 }, "to" : { "x" : 1419, "y" : 681 } } ], "endShape" : { "a" : { "x" : 1419, "y" : 689 }, "b" : { "x" : 1419, "y" : 681 }, "c" : { "x" : 1412, "y" : 685 }, "type" : "ARROW", "centre" : { "x" : 1412, "y" : 685 } }, "reactionShape" : { "a" : { "x" : 1341, "y" : 791 }, "b" : { "x" : 1353, "y" : 803 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1347, "y" : 797 } }, "inputs" : [ { "id" : 32840 } ], "outputs" : [ { "id" : 32841 } ] }, { "id" : 32807, "reactomeId" : 10326696, "displayName" : "Ubiquitinated CD274 is degraded by the 26S proteasome", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 341, "y" : 174 }, "minX" : 64, "maxX" : 348, "minY" : 168, "maxY" : 395, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 266, "y" : 174 }, "to" : { "x" : 341, "y" : 174 } }, { "from" : { "x" : 341, "y" : 174 }, "to" : { "x" : 348, "y" : 393 } }, { "from" : { "x" : 348, "y" : 393 }, "to" : { "x" : 141, "y" : 395 } }, { "from" : { "x" : 141, "y" : 395 }, "to" : { "x" : 64, "y" : 360 } } ], "reactionShape" : { "a" : { "x" : 335, "y" : 168 }, "b" : { "x" : 347, "y" : 180 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 341, "y" : 174 } }, "inputs" : [ { "id" : 32804 } ], "outputs" : [ { "id" : 32800, "points" : [ { "x" : 107, "y" : 441 } ] }, { "id" : 32803, "points" : [ { "x" : 192, "y" : 279 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 32808, "points" : [ { "x" : 407, "y" : 182 } ] } ] }, { "id" : 32809, "reactomeId" : 10326997, "displayName" : "NEK2 phosphorylates CD274", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 344, "y" : 742 }, "minX" : 338, "maxX" : 350, "minY" : 702, "maxY" : 783, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 345, "y" : 783 }, "to" : { "x" : 344, "y" : 742 } }, { "from" : { "x" : 344, "y" : 742 }, "to" : { "x" : 346, "y" : 702 } } ], "endShape" : { "a" : { "x" : 350, "y" : 709 }, "b" : { "x" : 346, "y" : 702 }, "c" : { "x" : 342, "y" : 709 }, "type" : "ARROW", "centre" : { "x" : 342, "y" : 709 } }, "reactionShape" : { "a" : { "x" : 338, "y" : 736 }, "b" : { "x" : 350, "y" : 748 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 344, "y" : 742 } }, "inputs" : [ { "id" : 32810 } ], "outputs" : [ { "id" : 32795 } ], "catalysts" : [ { "id" : 32811, "points" : [ { "x" : 397, "y" : 742 } ] } ] }, { "id" : 32842, "reactomeId" : 10326985, "displayName" : "B3GNT3 mediated CD274 glycosylation in Golgi", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1567, "y" : 568 }, "minX" : 1535, "maxX" : 1662, "minY" : 562, "maxY" : 622, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1535, "y" : 622 }, "to" : { "x" : 1567, "y" : 568 } }, { "from" : { "x" : 1567, "y" : 568 }, "to" : { "x" : 1662, "y" : 566 } } ], "reactionShape" : { "a" : { "x" : 1561, "y" : 562 }, "b" : { "x" : 1573, "y" : 574 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1567, "y" : 568 } }, "inputs" : [ { "id" : 32843, "points" : [ { "x" : 1551, "y" : 689 } ] }, { "id" : 32841, "points" : [ { "x" : 1488, "y" : 637 } ] } ], "outputs" : [ { "id" : 32844, "points" : [ { "x" : 1754, "y" : 568 } ] }, { "id" : 32845, "points" : [ { "x" : 1662, "y" : 612 } ] } ], "catalysts" : [ { "id" : 32846, "points" : [ { "x" : 1504, "y" : 566 } ] } ] }, { "id" : 32780, "reactomeId" : 10327006, "displayName" : "CK2 phosphorylates CD274", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 529, "y" : 386 }, "minX" : 523, "maxX" : 535, "minY" : 380, "maxY" : 392, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 529, "y" : 388 }, "to" : { "x" : 529, "y" : 386 } }, { "from" : { "x" : 529, "y" : 386 }, "to" : { "x" : 528, "y" : 387 } } ], "reactionShape" : { "a" : { "x" : 523, "y" : 380 }, "b" : { "x" : 535, "y" : 392 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 529, "y" : 386 } }, "inputs" : [ { "id" : 32781, "points" : [ { "x" : 586, "y" : 362 } ] }, { "id" : 32782, "points" : [ { "x" : 476, "y" : 423 } ] } ], "outputs" : [ { "id" : 32783, "points" : [ { "x" : 597, "y" : 417 } ] }, { "id" : 32784, "points" : [ { "x" : 471, "y" : 372 } ] } ], "catalysts" : [ { "id" : 32785, "points" : [ { "x" : 529, "y" : 335 } ] } ] }, { "id" : 32812, "reactomeId" : 10326980, "displayName" : "AMPK phosphorylates CD274", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 345, "y" : 892 }, "minX" : 338, "maxX" : 350, "minY" : 865, "maxY" : 914, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 344, "y" : 871 }, "to" : { "x" : 345, "y" : 892 } }, { "from" : { "x" : 345, "y" : 892 }, "to" : { "x" : 346, "y" : 914 } } ], "reactionShape" : { "a" : { "x" : 339, "y" : 886 }, "b" : { "x" : 351, "y" : 898 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 345, "y" : 892 } }, "inputs" : [ { "id" : 32810, "points" : [ { "x" : 345, "y" : 840 } ] }, { "id" : 32813, "points" : [ { "x" : 446, "y" : 827 } ] } ], "outputs" : [ { "id" : 32814, "points" : [ { "x" : 395, "y" : 942 } ] }, { "id" : 32815, "points" : [ { "x" : 413, "y" : 900 } ] } ], "catalysts" : [ { "id" : 32816, "points" : [ { "x" : 574, "y" : 865 } ] } ] }, { "id" : 32847, "reactomeId" : 10327013, "displayName" : "MIB2-mediated K63-ubiquitination of CD274", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1819, "y" : 727 }, "minX" : 1813, "maxX" : 1825, "minY" : 689, "maxY" : 763, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1819, "y" : 689 }, "to" : { "x" : 1819, "y" : 727 } }, { "from" : { "x" : 1819, "y" : 727 }, "to" : { "x" : 1820, "y" : 763 } } ], "endShape" : { "a" : { "x" : 1816, "y" : 756 }, "b" : { "x" : 1820, "y" : 763 }, "c" : { "x" : 1824, "y" : 756 }, "type" : "ARROW", "centre" : { "x" : 1824, "y" : 756 } }, "reactionShape" : { "a" : { "x" : 1813, "y" : 721 }, "b" : { "x" : 1825, "y" : 733 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1819, "y" : 727 } }, "inputs" : [ { "id" : 32844, "points" : [ { "x" : 1821, "y" : 599 } ] }, { "id" : 32848, "points" : [ { "x" : 1762, "y" : 689 } ] } ], "outputs" : [ { "id" : 32849 } ], "catalysts" : [ { "id" : 32850, "points" : [ { "x" : 1754, "y" : 729 } ] } ] }, { "id" : 32817, "reactomeId" : 10326990, "displayName" : "p-S195-CD274 binds ERAD complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 662, "y" : 915 }, "minX" : 656, "maxX" : 713, "minY" : 909, "maxY" : 949, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 664, "y" : 914 }, "to" : { "x" : 662, "y" : 915 } }, { "from" : { "x" : 662, "y" : 915 }, "to" : { "x" : 713, "y" : 949 } } ], "endShape" : { "a" : { "x" : 705, "y" : 948 }, "b" : { "x" : 713, "y" : 949 }, "c" : { "x" : 709, "y" : 942 }, "type" : "ARROW", "centre" : { "x" : 709, "y" : 942 } }, "reactionShape" : { "c" : { "x" : 662, "y" : 915 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 662, "y" : 915 } }, "inputs" : [ { "id" : 32814, "points" : [ { "x" : 497, "y" : 942 }, { "x" : 536, "y" : 919 } ] }, { "id" : 32818, "points" : [ { "x" : 631, "y" : 937 } ] } ], "outputs" : [ { "id" : 32819 } ] }, { "id" : 32786, "reactomeId" : 10326748, "displayName" : "CD274 ubiquitination by SPOP:CUL3:RBX1 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 941, "y" : 281 }, "minX" : 920, "maxX" : 1093, "minY" : 261, "maxY" : 287, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 920, "y" : 261 }, "to" : { "x" : 941, "y" : 281 } }, { "from" : { "x" : 941, "y" : 281 }, "to" : { "x" : 1093, "y" : 286 } } ], "endShape" : { "a" : { "x" : 1086, "y" : 290 }, "b" : { "x" : 1093, "y" : 286 }, "c" : { "x" : 1086, "y" : 282 }, "type" : "ARROW", "centre" : { "x" : 1086, "y" : 282 } }, "reactionShape" : { "a" : { "x" : 935, "y" : 275 }, "b" : { "x" : 947, "y" : 287 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 941, "y" : 281 } }, "inputs" : [ { "id" : 32787, "points" : [ { "x" : 906, "y" : 242 } ], "stoichiometry" : 3 }, { "id" : 32788, "points" : [ { "x" : 859, "y" : 275 } ] } ], "outputs" : [ { "id" : 32789 } ], "catalysts" : [ { "id" : 32788, "points" : [ { "x" : 859, "y" : 300 }, { "x" : 904, "y" : 311 } ] } ] }, { "id" : 32851, "reactomeId" : 10326952, "displayName" : "K63-Ub-polyLacNac-Glycosylated CD274 transport to plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1931, "y" : 793 }, "minX" : 1889, "maxX" : 1937, "minY" : 273, "maxY" : 799, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1889, "y" : 795 }, "to" : { "x" : 1931, "y" : 793 } }, { "from" : { "x" : 1931, "y" : 793 }, "to" : { "x" : 1933, "y" : 273 } } ], "endShape" : { "a" : { "x" : 1937, "y" : 280 }, "b" : { "x" : 1933, "y" : 273 }, "c" : { "x" : 1929, "y" : 280 }, "type" : "ARROW", "centre" : { "x" : 1929, "y" : 280 } }, "reactionShape" : { "a" : { "x" : 1925, "y" : 787 }, "b" : { "x" : 1937, "y" : 799 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1931, "y" : 793 } }, "inputs" : [ { "id" : 32849 } ], "outputs" : [ { "id" : 32852 } ] }, { "id" : 32820, "reactomeId" : 10326988, "displayName" : "Ubiquitination of CD274 by ERAD complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 897, "y" : 908 }, "minX" : 843, "maxX" : 968, "minY" : 902, "maxY" : 936, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 843, "y" : 927 }, "to" : { "x" : 897, "y" : 908 } }, { "from" : { "x" : 897, "y" : 908 }, "to" : { "x" : 968, "y" : 936 } } ], "endShape" : { "a" : { "x" : 960, "y" : 937 }, "b" : { "x" : 968, "y" : 936 }, "c" : { "x" : 963, "y" : 930 }, "type" : "ARROW", "centre" : { "x" : 963, "y" : 930 } }, "reactionShape" : { "a" : { "x" : 891, "y" : 902 }, "b" : { "x" : 903, "y" : 914 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 897, "y" : 908 } }, "inputs" : [ { "id" : 32819, "points" : [ { "x" : 797, "y" : 949 } ] }, { "id" : 32821, "points" : [ { "x" : 857, "y" : 941 } ] } ], "outputs" : [ { "id" : 32822 } ], "catalysts" : [ { "id" : 32819, "points" : [ { "x" : 750, "y" : 949 }, { "x" : 750, "y" : 909 } ] } ] }, { "id" : 32853, "reactomeId" : 10327517, "displayName" : "PD-1 binds PD-L1,PD-L2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1752, "y" : 74 }, "minX" : 1746, "maxX" : 1884, "minY" : 68, "maxY" : 103, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1754, "y" : 74 }, "to" : { "x" : 1752, "y" : 74 } }, { "from" : { "x" : 1752, "y" : 74 }, "to" : { "x" : 1884, "y" : 103 } } ], "endShape" : { "a" : { "x" : 1876, "y" : 105 }, "b" : { "x" : 1884, "y" : 103 }, "c" : { "x" : 1878, "y" : 98 }, "type" : "ARROW", "centre" : { "x" : 1878, "y" : 98 } }, "reactionShape" : { "c" : { "x" : 1752, "y" : 74 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1752, "y" : 74 } }, "inputs" : [ { "id" : 32854, "points" : [ { "x" : 1533, "y" : 36 } ] }, { "id" : 32855, "points" : [ { "x" : 1701, "y" : 49 } ] } ], "outputs" : [ { "id" : 32856 } ], "inhibitors" : [ { "id" : 32857, "points" : [ { "x" : 1828, "y" : 49 } ] } ] }, { "id" : 32790, "reactomeId" : 10326721, "displayName" : "GSK3B phosphorylates CD274", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 488, "y" : 574 }, "minX" : 482, "maxX" : 494, "minY" : 529, "maxY" : 580, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 491, "y" : 529 }, "to" : { "x" : 488, "y" : 574 } }, { "from" : { "x" : 488, "y" : 574 }, "to" : { "x" : 489, "y" : 575 } } ], "reactionShape" : { "a" : { "x" : 482, "y" : 568 }, "b" : { "x" : 494, "y" : 580 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 488, "y" : 574 } }, "inputs" : [ { "id" : 32791, "points" : [ { "x" : 511, "y" : 527 } ] }, { "id" : 32782, "points" : [ { "x" : 456, "y" : 480 } ] } ], "outputs" : [ { "id" : 32792, "points" : [ { "x" : 408, "y" : 573 } ] }, { "id" : 32793, "points" : [ { "x" : 496, "y" : 641 } ] } ], "catalysts" : [ { "id" : 32794, "points" : [ { "x" : 604, "y" : 577 } ] } ], "inhibitors" : [ { "id" : 32795, "points" : [ { "x" : 398, "y" : 631 } ] }, { "id" : 32796, "points" : [ { "x" : 901, "y" : 470 }, { "x" : 706, "y" : 533 } ] } ] }, { "id" : 32823, "reactomeId" : 10326920, "displayName" : "Active transport of ubiquitinated CD274 from ER to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1101, "y" : 892 }, "minX" : 1095, "maxX" : 1107, "minY" : 886, "maxY" : 898, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 1103, "y" : 891 }, "to" : { "x" : 1101, "y" : 892 } }, { "from" : { "x" : 1101, "y" : 892 }, "to" : { "x" : 1099, "y" : 890 } } ], "reactionShape" : { "c" : { "x" : 1101, "y" : 892 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 1101, "y" : 892 } }, "inputs" : [ { "id" : 32822, "points" : [ { "x" : 1079, "y" : 910 } ] }, { "id" : 32824, "points" : [ { "x" : 984, "y" : 806 } ] }, { "id" : 32825, "points" : [ { "x" : 943, "y" : 850 } ] } ], "outputs" : [ { "id" : 32826, "points" : [ { "x" : 1116, "y" : 863 } ] }, { "id" : 32827, "points" : [ { "x" : 1073, "y" : 824 } ] }, { "id" : 32818, "points" : [ { "x" : 643, "y" : 943 }, { "x" : 745, "y" : 882 } ] }, { "id" : 32828, "points" : [ { "x" : 1311, "y" : 967 } ] } ] }, { "id" : 32829, "reactomeId" : 10326992, "displayName" : "Proteasomal degradation of polyUb-p-S195-CD274", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1488, "y" : 986 }, "minX" : 1421, "maxX" : 1579, "minY" : 980, "maxY" : 992, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1421, "y" : 987 }, "to" : { "x" : 1488, "y" : 986 } }, { "from" : { "x" : 1488, "y" : 986 }, "to" : { "x" : 1579, "y" : 986 } } ], "endShape" : { "a" : { "x" : 1572, "y" : 990 }, "b" : { "x" : 1579, "y" : 986 }, "c" : { "x" : 1572, "y" : 982 }, "type" : "ARROW", "centre" : { "x" : 1572, "y" : 982 } }, "reactionShape" : { "a" : { "x" : 1482, "y" : 980 }, "b" : { "x" : 1494, "y" : 992 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1488, "y" : 986 } }, "inputs" : [ { "id" : 32828 } ], "outputs" : [ { "id" : 32830 } ], "catalysts" : [ { "id" : 32831, "points" : [ { "x" : 1488, "y" : 958 } ] } ] }, { "id" : 32797, "reactomeId" : 10327008, "displayName" : "Transport of p-S184,T180-CD274 to cytosol", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 338, "y" : 495 }, "minX" : 303, "maxX" : 344, "minY" : 489, "maxY" : 538, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 337, "y" : 538 }, "to" : { "x" : 338, "y" : 495 } }, { "from" : { "x" : 338, "y" : 495 }, "to" : { "x" : 303, "y" : 498 } } ], "endShape" : { "a" : { "x" : 310, "y" : 493 }, "b" : { "x" : 303, "y" : 498 }, "c" : { "x" : 310, "y" : 501 }, "type" : "ARROW", "centre" : { "x" : 310, "y" : 501 } }, "reactionShape" : { "a" : { "x" : 332, "y" : 489 }, "b" : { "x" : 344, "y" : 501 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 338, "y" : 495 } }, "inputs" : [ { "id" : 32792 } ], "outputs" : [ { "id" : 32798 } ] }, { "id" : 32799, "reactomeId" : 10326705, "displayName" : "p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 219, "y" : 456 }, "minX" : 213, "maxX" : 225, "minY" : 377, "maxY" : 462, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 219, "y" : 456 }, "to" : { "x" : 217, "y" : 428 } }, { "from" : { "x" : 217, "y" : 428 }, "to" : { "x" : 215, "y" : 377 } } ], "endShape" : { "a" : { "x" : 219, "y" : 384 }, "b" : { "x" : 215, "y" : 377 }, "c" : { "x" : 211, "y" : 384 }, "type" : "ARROW", "centre" : { "x" : 211, "y" : 384 } }, "reactionShape" : { "c" : { "x" : 219, "y" : 456 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 219, "y" : 456 } }, "inputs" : [ { "id" : 32798, "points" : [ { "x" : 236, "y" : 481 } ] }, { "id" : 32800, "points" : [ { "x" : 178, "y" : 459 } ] } ], "outputs" : [ { "id" : 32801 } ] } ], "compartments" : [ { "id" : 32858, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 995, "y" : 520 }, "minX" : 0, "maxX" : 1991, "minY" : 7, "maxY" : 1033, "prop" : { "x" : 0, "y" : 7, "width" : 1991, "height" : 1026 }, "textPosition" : { "x" : 18, "y" : 30 }, "insets" : { "x" : 10, "y" : 17, "width" : 1971, "height" : 1006 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 32859, 32860, 32774, 32775, 32776, 32777, 32778, 32788, 32780, 32785, 32781, 32784, 32786, 32787, 32789, 32798, 32799, 32800, 32801, 32802, 32804, 32803, 32805, 32806, 32807, 32808, 32828, 32829, 32831, 32830, 32839, 32851, 32852, 32863, 32865, 32853, 32854, 32855, 32866, 32857, 32856, 32867, 32779 ] }, { "id" : 32859, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 787, "y" : 710 }, "minX" : 322, "maxX" : 1252, "minY" : 434, "maxY" : 987, "prop" : { "x" : 322, "y" : 434, "width" : 930, "height" : 553 }, "textPosition" : { "x" : 707, "y" : 692 }, "insets" : { "x" : 332, "y" : 444, "width" : 910, "height" : 533 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 32782, 32783, 32795, 32796, 32793, 32792, 32790, 32791, 32794, 32797, 32809, 32811, 32810, 32815, 32812, 32816, 32814, 32813, 32817, 32818, 32819, 32820, 32822, 32821, 32823, 32826, 32836, 32835, 32832, 32834, 32833, 32838, 32837, 32825, 32827, 32824, 32840 ] }, { "id" : 32860, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1621, "y" : 724 }, "minX" : 1411, "maxX" : 1831, "minY" : 555, "maxY" : 894, "prop" : { "x" : 1411, "y" : 555, "width" : 420, "height" : 339 }, "textPosition" : { "x" : 1442, "y" : 582 }, "insets" : { "x" : 1421, "y" : 565, "width" : 400, "height" : 319 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 32841, 32843, 32846, 32845, 32844, 32842, 32847, 32849, 32848, 32850 ] } ], "notes" : [ ], "links" : [ { "id" : 32865, "renderableClass" : "Interaction", "position" : { "x" : 1788, "y" : 233 }, "minX" : 1719, "maxX" : 1858, "minY" : 227, "maxY" : 239, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1858, "y" : 234 }, "to" : { "x" : 1719, "y" : 233 } } ], "endShape" : { "a" : { "x" : 1726, "y" : 229 }, "b" : { "x" : 1719, "y" : 233 }, "c" : { "x" : 1726, "y" : 237 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1726, "y" : 237 } }, "reactionShape" : { "a" : { "x" : 1782, "y" : 227 }, "b" : { "x" : 1794, "y" : 239 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1788, "y" : 233 } }, "inputs" : [ { "id" : 32852 } ], "outputs" : [ { "id" : 32863 } ] }, { "id" : 32866, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1791, "y" : 123 }, "minX" : 1694, "maxX" : 1889, "minY" : 49, "maxY" : 198, "segments" : [ { "from" : { "x" : 1889, "y" : 198 }, "to" : { "x" : 1694, "y" : 49 } } ], "reactionShape" : { "a" : { "x" : 1785, "y" : 117 }, "b" : { "x" : 1797, "y" : 129 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1791, "y" : 123 } }, "inputs" : [ { "id" : 32852 } ], "outputs" : [ { "id" : 32855 } ] }, { "id" : 32867, "renderableClass" : "Interaction", "position" : { "x" : 1811, "y" : 167 }, "minX" : 1719, "maxX" : 1903, "minY" : 135, "maxY" : 199, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1903, "y" : 135 }, "to" : { "x" : 1719, "y" : 199 } } ], "endShape" : { "a" : { "x" : 1724, "y" : 193 }, "b" : { "x" : 1719, "y" : 199 }, "c" : { "x" : 1727, "y" : 201 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1727, "y" : 201 } }, "reactionShape" : { "a" : { "x" : 1805, "y" : 161 }, "b" : { "x" : 1817, "y" : 173 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1811, "y" : 167 } }, "inputs" : [ { "id" : 32856 } ], "outputs" : [ { "id" : 32863 } ] } ], "shadows" : [ { "id" : 32868, "reactomeId" : 10332001, "displayName" : "GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 533, "y" : 493 }, "minX" : 17, "maxX" : 1049, "minY" : 140, "maxY" : 847, "prop" : { "x" : 17, "y" : 140, "width" : 243, "height" : 707 }, "points" : [ { "x" : 17, "y" : 140 }, { "x" : 1049, "y" : 140 }, { "x" : 1049, "y" : 847 }, { "x" : 17, "y" : 847 } ], "colour" : "#4684ee" }, { "id" : 32869, "reactomeId" : 10332005, "displayName" : "SPOP-mediated proteasomal degradation of PD-L1(CD274)", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 773, "y" : 260 }, "minX" : 322, "maxX" : 1225, "minY" : 31, "maxY" : 489, "prop" : { "x" : 322, "y" : 31, "width" : 903, "height" : 109 }, "points" : [ { "x" : 322, "y" : 31 }, { "x" : 1225, "y" : 31 }, { "x" : 1225, "y" : 489 }, { "x" : 322, "y" : 489 } ], "colour" : "#dc3912" }, { "id" : 32870, "reactomeId" : 10332009, "displayName" : "PD-L1(CD274) glycosylation and translocation to plasma membrane", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1139, "y" : 451 }, "minX" : 260, "maxX" : 2018, "minY" : -4, "maxY" : 906, "prop" : { "x" : 1225, "y" : 31, "width" : 793, "height" : 458 }, "points" : [ { "x" : 260, "y" : -4 }, { "x" : 2018, "y" : -4 }, { "x" : 2018, "y" : 906 }, { "x" : 260, "y" : 906 } ], "colour" : "#008000" }, { "id" : 32871, "reactomeId" : 10332011, "displayName" : "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 970, "y" : 893 }, "minX" : 269, "maxX" : 1671, "minY" : 766, "maxY" : 1020, "prop" : { "x" : 269, "y" : 906, "width" : 1402, "height" : 114 }, "points" : [ { "x" : 269, "y" : 766 }, { "x" : 1671, "y" : 766 }, { "x" : 1671, "y" : 1020 }, { "x" : 269, "y" : 1020 } ], "colour" : "#666666" } ], "minX" : 0, "maxX" : 2014, "minY" : 0, "maxY" : 1033, "disease" : false }