{ "dbId" : 10331987, "stableId" : "R-CFA-9865881", "displayName" : "Complex III assembly", "nodes" : [ { "id" : 103041, "reactomeId" : 10326131, "displayName" : "LYRM7", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2021, "y" : 566 }, "minX" : 1961, "maxX" : 2161, "minY" : 322, "maxY" : 578, "prop" : { "x" : 1998, "y" : 555, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1998, "y" : 556 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2045, "y" : 555 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2045, "y" : 555 } } }, "connectors" : [ { "edgeId" : 103043, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2038, "y" : 552 }, "to" : { "x" : 2161, "y" : 472 } }, { "from" : { "x" : 2161, "y" : 472 }, "to" : { "x" : 1961, "y" : 322 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2042, "y" : 545 }, "b" : { "x" : 2038, "y" : 552 }, "c" : { "x" : 2046, "y" : 552 }, "type" : "ARROW", "centre" : { "x" : 2046, "y" : 552 } } }, { "edgeId" : 103039, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2003, "y" : 552 }, "to" : { "x" : 1962, "y" : 528 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 103039, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2021, "y" : 552 }, "to" : { "x" : 2021, "y" : 526 } }, { "from" : { "x" : 2021, "y" : 526 }, "to" : { "x" : 1977, "y" : 526 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1973, "y" : 526 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1973, "y" : 526 } } } ] }, { "id" : 103040, "reactomeId" : 10326135, "displayName" : "UQCRFS1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1908, "y" : 564 }, "minX" : 1875, "maxX" : 1962, "minY" : 528, "maxY" : 580, "prop" : { "x" : 1875, "y" : 549, "width" : 66, "height" : 31 }, "textPosition" : { "x" : 1875, "y" : 554 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1941, "y" : 549 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1941, "y" : 549 } } }, "connectors" : [ { "edgeId" : 103039, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1931, "y" : 546 }, "to" : { "x" : 1962, "y" : 528 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 103042, "reactomeId" : 10326137, "displayName" : "UQCRFS1(1-274):LYRM7", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1962, "y" : 460 }, "minX" : 1928, "maxX" : 2002, "minY" : 389, "maxY" : 487, "prop" : { "x" : 1928, "y" : 434, "width" : 68, "height" : 53 }, "textPosition" : { "x" : 1929, "y" : 438 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1996, "y" : 434 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1996, "y" : 434 } } }, "connectors" : [ { "edgeId" : 103043, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1961, "y" : 431 }, "to" : { "x" : 1961, "y" : 389 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 103039, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 103045, "reactomeId" : 10326144, "displayName" : "holo-UQCRFS1(1-274)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1958, "y" : 207 }, "minX" : 1925, "maxX" : 1998, "minY" : 179, "maxY" : 322, "prop" : { "x" : 1925, "y" : 185, "width" : 67, "height" : 45 }, "textPosition" : { "x" : 1926, "y" : 181 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1992, "y" : 185 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1992, "y" : 185 } } }, "connectors" : [ { "edgeId" : 103043, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1958, "y" : 233 }, "to" : { "x" : 1961, "y" : 322 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1962, "y" : 240 }, "b" : { "x" : 1958, "y" : 233 }, "c" : { "x" : 1954, "y" : 240 }, "type" : "ARROW", "centre" : { "x" : 1954, "y" : 240 } } } ] }, { "id" : 103044, "reactomeId" : 10267328, "displayName" : "FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1857, "y" : 423 }, "minX" : 1793, "maxX" : 1961, "minY" : 357, "maxY" : 442, "prop" : { "x" : 1793, "y" : 405, "width" : 128, "height" : 37 }, "textPosition" : { "x" : 1801, "y" : 393 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1921, "y" : 405 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1921, "y" : 405 } } }, "connectors" : [ { "edgeId" : 103043, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1913, "y" : 402 }, "to" : { "x" : 1961, "y" : 389 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 103043, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1885, "y" : 402 }, "to" : { "x" : 1947, "y" : 363 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1951, "y" : 361 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1951, "y" : 361 } } } ] }, { "id" : 103047, "reactomeId" : 10299182, "displayName" : "HSPA9:HSCB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1784, "y" : 309 }, "minX" : 1744, "maxX" : 1952, "minY" : 292, "maxY" : 355, "prop" : { "x" : 1744, "y" : 298, "width" : 80, "height" : 23 }, "textPosition" : { "x" : 1757, "y" : 286 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1824, "y" : 298 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1824, "y" : 298 } } }, "connectors" : [ { "edgeId" : 103043, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1827, "y" : 319 }, "to" : { "x" : 1952, "y" : 353 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1944, "y" : 355 }, "b" : { "x" : 1952, "y" : 353 }, "c" : { "x" : 1946, "y" : 347 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1946, "y" : 347 } } } ] }, { "id" : 103046, "reactomeId" : 10267334, "displayName" : "FXN:ISD11:NFS1:ISCU", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2127, "y" : 301 }, "minX" : 1961, "maxX" : 2195, "minY" : 278, "maxY" : 322, "prop" : { "x" : 2066, "y" : 284, "width" : 123, "height" : 34 }, "textPosition" : { "x" : 2072, "y" : 283 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2189, "y" : 284 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2189, "y" : 284 } } }, "connectors" : [ { "edgeId" : 103043, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2063, "y" : 308 }, "to" : { "x" : 1961, "y" : 322 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2057, "y" : 313 }, "b" : { "x" : 2063, "y" : 308 }, "c" : { "x" : 2056, "y" : 305 }, "type" : "ARROW", "centre" : { "x" : 2056, "y" : 305 } } } ] }, { "id" : 103050, "reactomeId" : 9853511, "displayName" : "heme b", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 557, "y" : 222 }, "minX" : 531, "maxX" : 585, "minY" : 208, "maxY" : 236, "prop" : { "x" : 531, "y" : 209, "width" : 53, "height" : 27 }, "textPosition" : { "x" : 534, "y" : 205 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 579, "y" : 214 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 579, "y" : 214 } } }, "connectors" : [ ] }, { "id" : 103053, "reactomeId" : 9853511, "displayName" : "heme b", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 880, "y" : 221 }, "minX" : 853, "maxX" : 908, "minY" : 206, "maxY" : 236, "prop" : { "x" : 853, "y" : 207, "width" : 54, "height" : 29 }, "textPosition" : { "x" : 856, "y" : 204 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 902, "y" : 212 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 902, "y" : 212 } } }, "connectors" : [ ] }, { "id" : 103055, "reactomeId" : 10328657, "displayName" : "Respiratory electron transport", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2899, "y" : 322 }, "minX" : 2830, "maxX" : 2968, "minY" : 297, "maxY" : 348, "prop" : { "x" : 2830, "y" : 297, "width" : 138, "height" : 51 }, "textPosition" : { "x" : 2833, "y" : 301 }, "connectors" : [ ] }, { "id" : 103054, "reactomeId" : 10330735, "displayName" : "Mitochondrial iron-sulfur cluster biogenesis", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1621, "y" : 478 }, "minX" : 1558, "maxX" : 1684, "minY" : 445, "maxY" : 511, "prop" : { "x" : 1558, "y" : 445, "width" : 126, "height" : 66 }, "textPosition" : { "x" : 1556, "y" : 449 }, "connectors" : [ ] }, { "id" : 103057, "reactomeId" : 10329641, "displayName" : "Metabolism of porphyrins", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 719, "y" : 395 }, "minX" : 662, "maxX" : 777, "minY" : 371, "maxY" : 419, "prop" : { "x" : 662, "y" : 371, "width" : 115, "height" : 48 }, "textPosition" : { "x" : 666, "y" : 373 }, "connectors" : [ ] }, { "id" : 103056, "reactomeId" : 10331147, "displayName" : "Mitochondrial translation", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 310, "y" : 360 }, "minX" : 254, "maxX" : 366, "minY" : 334, "maxY" : 387, "prop" : { "x" : 254, "y" : 334, "width" : 112, "height" : 53 }, "textPosition" : { "x" : 258, "y" : 339 }, "connectors" : [ ] } ], "edges" : [ { "id" : 103043, "reactomeId" : 10326147, "displayName" : "2Fe-2S is inserted in UQCRFS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1961, "y" : 355 }, "minX" : 1955, "maxX" : 1967, "minY" : 322, "maxY" : 389, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1961, "y" : 389 }, "to" : { "x" : 1961, "y" : 355 } }, { "from" : { "x" : 1961, "y" : 355 }, "to" : { "x" : 1961, "y" : 322 } } ], "reactionShape" : { "a" : { "x" : 1955, "y" : 349 }, "b" : { "x" : 1967, "y" : 361 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1961, "y" : 355 } }, "inputs" : [ { "id" : 103044, "points" : [ { "x" : 1913, "y" : 402 } ] }, { "id" : 103042, "points" : [ { "x" : 1961, "y" : 431 } ] } ], "outputs" : [ { "id" : 103045, "points" : [ { "x" : 1958, "y" : 233 } ] }, { "id" : 103046, "points" : [ { "x" : 2063, "y" : 308 } ] }, { "id" : 103041, "points" : [ { "x" : 2038, "y" : 552 }, { "x" : 2161, "y" : 472 } ] } ], "catalysts" : [ { "id" : 103044, "points" : [ { "x" : 1885, "y" : 402 } ] } ], "activators" : [ { "id" : 103047, "points" : [ { "x" : 1827, "y" : 319 } ] } ] }, { "id" : 103039, "reactomeId" : 10326140, "displayName" : "apo-UQCRFS1 binds LYRM7", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1961, "y" : 526 }, "minX" : 1955, "maxX" : 1967, "minY" : 490, "maxY" : 532, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1962, "y" : 528 }, "to" : { "x" : 1961, "y" : 526 } }, { "from" : { "x" : 1961, "y" : 526 }, "to" : { "x" : 1961, "y" : 490 } } ], "endShape" : { "a" : { "x" : 1965, "y" : 497 }, "b" : { "x" : 1961, "y" : 490 }, "c" : { "x" : 1957, "y" : 497 }, "type" : "ARROW", "centre" : { "x" : 1957, "y" : 497 } }, "reactionShape" : { "a" : { "x" : 1955, "y" : 520 }, "b" : { "x" : 1967, "y" : 532 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1961, "y" : 526 } }, "inputs" : [ { "id" : 103040, "points" : [ { "x" : 1931, "y" : 546 } ] }, { "id" : 103041, "points" : [ { "x" : 2003, "y" : 552 } ] } ], "outputs" : [ { "id" : 103042 } ], "catalysts" : [ { "id" : 103041, "points" : [ { "x" : 2021, "y" : 552 }, { "x" : 2021, "y" : 526 } ] } ] } ], "compartments" : [ { "id" : 103051, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1590, "y" : 405 }, "minX" : 85, "maxX" : 3095, "minY" : 55, "maxY" : 755, "prop" : { "x" : 85, "y" : 55, "width" : 3010, "height" : 700 }, "textPosition" : { "x" : 934, "y" : 384 }, "insets" : { "x" : 95, "y" : 65, "width" : 2990, "height" : 680 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 103050, 103053, 103045, 103042, 103039, 103041, 103047, 103043, 103044, 103046, 103040, 103054, 103058, 103055, 103059, 103056, 103057, 103060, 103061 ] }, { "id" : 103052, "reactomeId" : 17927, "displayName" : "mitochondrial intermembrane space", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1593, "y" : 437 }, "minX" : 0, "maxX" : 3187, "minY" : 0, "maxY" : 874, "prop" : { "x" : 0, "y" : 0, "width" : 3187, "height" : 874 }, "textPosition" : { "x" : 368, "y" : 20 }, "insets" : { "x" : 10, "y" : 10, "width" : 3167, "height" : 854 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 103051 ] } ], "notes" : [ ], "links" : [ { "id" : 103058, "renderableClass" : "Interaction", "position" : { "x" : 1738, "y" : 449 }, "minX" : 1687, "maxX" : 1790, "minY" : 437, "maxY" : 462, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1687, "y" : 462 }, "to" : { "x" : 1790, "y" : 437 } } ], "endShape" : { "a" : { "x" : 1784, "y" : 443 }, "b" : { "x" : 1790, "y" : 437 }, "c" : { "x" : 1782, "y" : 435 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1782, "y" : 435 } }, "reactionShape" : { "a" : { "x" : 1732, "y" : 443 }, "b" : { "x" : 1744, "y" : 455 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1738, "y" : 449 } }, "inputs" : [ { "id" : 103054 } ], "outputs" : [ { "id" : 103044 } ] }, { "id" : 103061, "renderableClass" : "Interaction", "position" : { "x" : 632, "y" : 303 }, "minX" : 569, "maxX" : 695, "minY" : 239, "maxY" : 368, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 695, "y" : 368 }, "to" : { "x" : 569, "y" : 239 } } ], "endShape" : { "a" : { "x" : 577, "y" : 241 }, "b" : { "x" : 569, "y" : 239 }, "c" : { "x" : 571, "y" : 247 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 571, "y" : 247 } }, "reactionShape" : { "a" : { "x" : 626, "y" : 297 }, "b" : { "x" : 638, "y" : 309 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 632, "y" : 303 } }, "inputs" : [ { "id" : 103057 } ], "outputs" : [ { "id" : 103050 } ] }, { "id" : 103060, "renderableClass" : "Interaction", "position" : { "x" : 803, "y" : 303 }, "minX" : 741, "maxX" : 866, "minY" : 239, "maxY" : 368, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 741, "y" : 368 }, "to" : { "x" : 866, "y" : 239 } } ], "endShape" : { "a" : { "x" : 864, "y" : 247 }, "b" : { "x" : 866, "y" : 239 }, "c" : { "x" : 858, "y" : 241 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 858, "y" : 241 } }, "reactionShape" : { "a" : { "x" : 797, "y" : 297 }, "b" : { "x" : 809, "y" : 309 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 803, "y" : 303 } }, "inputs" : [ { "id" : 103057 } ], "outputs" : [ { "id" : 103053 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 3187, "minY" : 0, "maxY" : 874, "disease" : false }