{
  "dbId" : 10331557,
  "stableId" : "R-CFA-8877330",
  "displayName" : "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)",
  "nodes" : [ {
    "id" : 87200,
    "reactomeId" : 10310934,
    "displayName" : "RUNX1:CBFB:FOXP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 515,
      "y" : 515
    },
    "minX" : 470,
    "maxX" : 566,
    "minY" : 491,
    "maxY" : 534,
    "prop" : {
      "x" : 470,
      "y" : 497,
      "width" : 90,
      "height" : 37
    },
    "textPosition" : {
      "x" : 471,
      "y" : 499
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 560,
          "y" : 497
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 560,
          "y" : 497
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87197,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87209,
    "reactomeId" : 10331517,
    "displayName" : "Transcriptional regulation by RUNX1",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 265,
      "y" : 276
    },
    "minX" : 185,
    "maxX" : 346,
    "minY" : 234,
    "maxY" : 319,
    "prop" : {
      "x" : 185,
      "y" : 234,
      "width" : 161,
      "height" : 85
    },
    "textPosition" : {
      "x" : 194,
      "y" : 255
    },
    "connectors" : [ ]
  }, {
    "id" : 87199,
    "reactomeId" : 10310932,
    "displayName" : "FOXP3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 259,
      "y" : 548
    },
    "minX" : 236,
    "maxX" : 389,
    "minY" : 481,
    "maxY" : 559,
    "prop" : {
      "x" : 236,
      "y" : 537,
      "width" : 47,
      "height" : 22
    },
    "textPosition" : {
      "x" : 236,
      "y" : 537
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 283,
          "y" : 537
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 283,
          "y" : 537
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87197,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 280,
          "y" : 534
        },
        "to" : {
          "x" : 389,
          "y" : 481
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 87198,
    "reactomeId" : 10308927,
    "displayName" : "RUNX1:CBFB",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 429,
      "y" : 363
    },
    "minX" : 387,
    "maxX" : 477,
    "minY" : 344,
    "maxY" : 481,
    "prop" : {
      "x" : 387,
      "y" : 350,
      "width" : 84,
      "height" : 27
    },
    "textPosition" : {
      "x" : 387,
      "y" : 356
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 471,
          "y" : 350
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 471,
          "y" : 350
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87197,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 424,
          "y" : 380
        },
        "to" : {
          "x" : 389,
          "y" : 481
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 87197,
    "reactomeId" : 10310936,
    "displayName" : "RUNX1 binds FOXP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 401,
      "y" : 504
    },
    "minX" : 389,
    "maxX" : 467,
    "minY" : 481,
    "maxY" : 510,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 389,
        "y" : 481
      },
      "to" : {
        "x" : 401,
        "y" : 504
      }
    }, {
      "from" : {
        "x" : 401,
        "y" : 504
      },
      "to" : {
        "x" : 467,
        "y" : 510
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 460,
        "y" : 513
      },
      "b" : {
        "x" : 467,
        "y" : 510
      },
      "c" : {
        "x" : 460,
        "y" : 505
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 460,
        "y" : 505
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 401,
        "y" : 504
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 401,
        "y" : 504
      }
    },
    "inputs" : [ {
      "id" : 87198,
      "points" : [ {
        "x" : 424,
        "y" : 380
      } ]
    }, {
      "id" : 87199,
      "points" : [ {
        "x" : 280,
        "y" : 534
      } ]
    } ],
    "outputs" : [ {
      "id" : 87200
    } ]
  } ],
  "compartments" : [ {
    "id" : 87201,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 548,
      "y" : 517
    },
    "minX" : 0,
    "maxX" : 1096,
    "minY" : 0,
    "maxY" : 1035,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1096,
      "height" : 1035
    },
    "textPosition" : {
      "x" : 25,
      "y" : 979
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1076,
      "height" : 1015
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 87202, 87208 ]
  }, {
    "id" : 87202,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 575,
      "y" : 517
    },
    "minX" : 114,
    "maxX" : 1037,
    "minY" : 32,
    "maxY" : 1003,
    "prop" : {
      "x" : 114,
      "y" : 32,
      "width" : 923,
      "height" : 971
    },
    "textPosition" : {
      "x" : 138,
      "y" : 751
    },
    "insets" : {
      "x" : 124,
      "y" : 42,
      "width" : 903,
      "height" : 951
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 87198, 87199, 87197, 87200, 87209, 87211, 87212 ]
  } ],
  "notes" : [ {
    "id" : 87208,
    "displayName" : "plasma membrane",
    "renderableClass" : "Note",
    "position" : {
      "x" : 952,
      "y" : 1024
    },
    "minX" : 874,
    "maxX" : 1031,
    "minY" : 1016,
    "maxY" : 1032,
    "prop" : {
      "x" : 874,
      "y" : 1016,
      "width" : 157,
      "height" : 16
    },
    "textPosition" : {
      "x" : 890,
      "y" : 1014
    }
  } ],
  "links" : [ {
    "id" : 87211,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 377,
      "y" : 331
    },
    "minX" : 349,
    "maxX" : 406,
    "minY" : 316,
    "maxY" : 347,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 349,
        "y" : 316
      },
      "to" : {
        "x" : 406,
        "y" : 347
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 398,
        "y" : 347
      },
      "b" : {
        "x" : 406,
        "y" : 347
      },
      "c" : {
        "x" : 402,
        "y" : 340
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 402,
        "y" : 340
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 371,
        "y" : 325
      },
      "b" : {
        "x" : 383,
        "y" : 337
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 377,
        "y" : 331
      }
    },
    "inputs" : [ {
      "id" : 87209
    } ],
    "outputs" : [ {
      "id" : 87198
    } ]
  }, {
    "id" : 87212,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 144,
      "y" : 558
    },
    "minX" : 138,
    "maxX" : 467,
    "minY" : 276,
    "maxY" : 584,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 182,
        "y" : 276
      },
      "to" : {
        "x" : 143,
        "y" : 276
      }
    }, {
      "from" : {
        "x" : 143,
        "y" : 276
      },
      "to" : {
        "x" : 144,
        "y" : 558
      }
    }, {
      "from" : {
        "x" : 144,
        "y" : 558
      },
      "to" : {
        "x" : 244,
        "y" : 584
      }
    }, {
      "from" : {
        "x" : 244,
        "y" : 584
      },
      "to" : {
        "x" : 467,
        "y" : 526
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 461,
        "y" : 532
      },
      "b" : {
        "x" : 467,
        "y" : 526
      },
      "c" : {
        "x" : 459,
        "y" : 524
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 459,
        "y" : 524
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 138,
        "y" : 552
      },
      "b" : {
        "x" : 150,
        "y" : 564
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 144,
        "y" : 558
      }
    },
    "inputs" : [ {
      "id" : 87209
    } ],
    "outputs" : [ {
      "id" : 87200
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1096,
  "minY" : 0,
  "maxY" : 1035,
  "disease" : false
}