{
  "dbId" : 10331505,
  "stableId" : "R-CFA-8856825",
  "displayName" : "Cargo recognition for clathrin-mediated endocytosis",
  "nodes" : [ {
    "id" : 110593,
    "reactomeId" : 10309145,
    "displayName" : "ADBRK1,2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 891,
      "y" : 486
    },
    "minX" : 857,
    "maxX" : 926,
    "minY" : 475,
    "maxY" : 571,
    "prop" : {
      "x" : 857,
      "y" : 475,
      "width" : 69,
      "height" : 22
    },
    "textPosition" : {
      "x" : 857,
      "y" : 475
    },
    "connectors" : [ {
      "edgeId" : 110588,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 893,
          "y" : 503
        },
        "to" : {
          "x" : 906,
          "y" : 563
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 907,
          "y" : 567
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 907,
          "y" : 567
        }
      }
    } ]
  }, {
    "id" : 110592,
    "reactomeId" : 10309139,
    "displayName" : "p-AVPR2:AVP(20-28)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1027,
      "y" : 580
    },
    "minX" : 935,
    "maxX" : 1092,
    "minY" : 556,
    "maxY" : 598,
    "prop" : {
      "x" : 969,
      "y" : 562,
      "width" : 117,
      "height" : 36
    },
    "textPosition" : {
      "x" : 971,
      "y" : 563
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1086,
          "y" : 562
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1086,
          "y" : 562
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110588,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 966,
          "y" : 579
        },
        "to" : {
          "x" : 935,
          "y" : 579
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 959,
          "y" : 583
        },
        "b" : {
          "x" : 966,
          "y" : 579
        },
        "c" : {
          "x" : 959,
          "y" : 575
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 959,
          "y" : 575
        }
      }
    } ]
  }, {
    "id" : 110595,
    "reactomeId" : 10309417,
    "displayName" : "PICALMs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1936,
      "y" : 78
    },
    "minX" : 1898,
    "maxX" : 1975,
    "minY" : 28,
    "maxY" : 90,
    "prop" : {
      "x" : 1898,
      "y" : 67,
      "width" : 77,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1907,
      "y" : 68
    },
    "connectors" : [ {
      "edgeId" : 110594,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1944,
          "y" : 61
        },
        "to" : {
          "x" : 1974,
          "y" : 28
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110597,
    "reactomeId" : 10309419,
    "displayName" : "PICALM:VAMP2,3,8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2090,
      "y" : 28
    },
    "minX" : 2042,
    "maxX" : 2145,
    "minY" : 0,
    "maxY" : 50,
    "prop" : {
      "x" : 2042,
      "y" : 6,
      "width" : 97,
      "height" : 44
    },
    "textPosition" : {
      "x" : 2053,
      "y" : 15
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2139,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2139,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110594,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110596,
    "reactomeId" : 10309409,
    "displayName" : "VAMP2,3,8",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1894,
      "y" : 27
    },
    "minX" : 1849,
    "maxX" : 1974,
    "minY" : 13,
    "maxY" : 41,
    "prop" : {
      "x" : 1849,
      "y" : 13,
      "width" : 91,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1857,
      "y" : 16
    },
    "connectors" : [ {
      "edgeId" : 110594,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1946,
          "y" : 27
        },
        "to" : {
          "x" : 1974,
          "y" : 28
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110599,
    "reactomeId" : 10284323,
    "displayName" : "AP-2 Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 73,
      "y" : 100
    },
    "minX" : 32,
    "maxX" : 200,
    "minY" : 76,
    "maxY" : 145,
    "prop" : {
      "x" : 32,
      "y" : 82,
      "width" : 82,
      "height" : 37
    },
    "textPosition" : {
      "x" : 43,
      "y" : 84
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 114,
          "y" : 82
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 114,
          "y" : 82
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110598,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 117,
          "y" : 114
        },
        "to" : {
          "x" : 200,
          "y" : 145
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110601,
    "reactomeId" : 10320225,
    "displayName" : "AP2:chlorpromazine",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 201,
      "y" : 91
    },
    "minX" : 141,
    "maxX" : 268,
    "minY" : 69,
    "maxY" : 108,
    "prop" : {
      "x" : 141,
      "y" : 75,
      "width" : 121,
      "height" : 33
    },
    "textPosition" : {
      "x" : 150,
      "y" : 73
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 262,
          "y" : 75
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 262,
          "y" : 75
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110598,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110600,
    "reactomeId" : 9648300,
    "displayName" : "chlorpromazine",
    "schemaClass" : "ChemicalDrug",
    "renderableClass" : "ChemicalDrug",
    "position" : {
      "x" : 97,
      "y" : 191
    },
    "minX" : 44,
    "maxX" : 200,
    "minY" : 145,
    "maxY" : 206,
    "prop" : {
      "x" : 44,
      "y" : 176,
      "width" : 107,
      "height" : 30
    },
    "textPosition" : {
      "x" : 46,
      "y" : 180
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 110598,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 130,
          "y" : 173
        },
        "to" : {
          "x" : 200,
          "y" : 145
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110604,
    "reactomeId" : 10331499,
    "displayName" : "Clathrin-mediated endocytosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2265,
      "y" : 413
    },
    "minX" : 2177,
    "maxX" : 2353,
    "minY" : 378,
    "maxY" : 448,
    "prop" : {
      "x" : 2177,
      "y" : 378,
      "width" : 176,
      "height" : 70
    },
    "textPosition" : {
      "x" : 2199,
      "y" : 391
    },
    "connectors" : [ ]
  }, {
    "id" : 110555,
    "reactomeId" : 10279066,
    "displayName" : "LRP2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1090,
      "y" : 31
    },
    "minX" : 1044,
    "maxX" : 1181,
    "minY" : 7,
    "maxY" : 49,
    "prop" : {
      "x" : 1044,
      "y" : 13,
      "width" : 92,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1071,
      "y" : 20
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1136,
          "y" : 13
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1136,
          "y" : 13
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110553,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1139,
          "y" : 32
        },
        "to" : {
          "x" : 1181,
          "y" : 33
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110554,
    "reactomeId" : 10308566,
    "displayName" : "DAB2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1130,
      "y" : 86
    },
    "minX" : 1093,
    "maxX" : 1181,
    "minY" : 33,
    "maxY" : 99,
    "prop" : {
      "x" : 1093,
      "y" : 74,
      "width" : 74,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1109,
      "y" : 76
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1167,
          "y" : 74
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1167,
          "y" : 74
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110553,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1142,
          "y" : 71
        },
        "to" : {
          "x" : 1181,
          "y" : 33
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110556,
    "reactomeId" : 10308574,
    "displayName" : "LRP2:DAB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1289,
      "y" : 32
    },
    "minX" : 1242,
    "maxX" : 1343,
    "minY" : 8,
    "maxY" : 50,
    "prop" : {
      "x" : 1242,
      "y" : 14,
      "width" : 95,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1252,
      "y" : 29
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1337,
          "y" : 14
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1337,
          "y" : 14
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110553,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110559,
    "reactomeId" : 10308550,
    "displayName" : "SYT dimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 643,
      "y" : 29
    },
    "minX" : 579,
    "maxX" : 768,
    "minY" : 11,
    "maxY" : 47,
    "prop" : {
      "x" : 579,
      "y" : 11,
      "width" : 128,
      "height" : 36
    },
    "textPosition" : {
      "x" : 605,
      "y" : 18
    },
    "connectors" : [ {
      "edgeId" : 110557,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 713,
          "y" : 30
        },
        "to" : {
          "x" : 768,
          "y" : 32
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110558,
    "reactomeId" : 10308560,
    "displayName" : "STON2,1",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 739,
      "y" : 75
    },
    "minX" : 683,
    "maxX" : 795,
    "minY" : 32,
    "maxY" : 249,
    "prop" : {
      "x" : 683,
      "y" : 64,
      "width" : 112,
      "height" : 22
    },
    "textPosition" : {
      "x" : 708,
      "y" : 64
    },
    "connectors" : [ {
      "edgeId" : 110565,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 736,
          "y" : 92
        },
        "to" : {
          "x" : 726,
          "y" : 129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110572,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 742,
          "y" : 92
        },
        "to" : {
          "x" : 788,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 748,
          "y" : 98
        },
        "b" : {
          "x" : 742,
          "y" : 92
        },
        "c" : {
          "x" : 740,
          "y" : 100
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 740,
          "y" : 100
        }
      }
    }, {
      "edgeId" : 110557,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 746,
          "y" : 58
        },
        "to" : {
          "x" : 768,
          "y" : 32
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110560,
    "reactomeId" : 10308562,
    "displayName" : "STON2,1:SYT dimers",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 918,
      "y" : 28
    },
    "minX" : 851,
    "maxX" : 991,
    "minY" : 4,
    "maxY" : 46,
    "prop" : {
      "x" : 851,
      "y" : 10,
      "width" : 134,
      "height" : 36
    },
    "textPosition" : {
      "x" : 851,
      "y" : 25
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 985,
          "y" : 10
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 985,
          "y" : 10
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110557,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110563,
    "reactomeId" : 10239122,
    "displayName" : "LDL:LDLR complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 382,
      "y" : 603
    },
    "minX" : 319,
    "maxX" : 498,
    "minY" : 570,
    "maxY" : 621,
    "prop" : {
      "x" : 319,
      "y" : 585,
      "width" : 126,
      "height" : 36
    },
    "textPosition" : {
      "x" : 323,
      "y" : 600
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 445,
          "y" : 585
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 445,
          "y" : 585
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110561,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 448,
          "y" : 585
        },
        "to" : {
          "x" : 498,
          "y" : 570
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110562,
    "reactomeId" : 10308568,
    "displayName" : "DAB2,LDLRAP1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 390,
      "y" : 554
    },
    "minX" : 318,
    "maxX" : 498,
    "minY" : 536,
    "maxY" : 572,
    "prop" : {
      "x" : 318,
      "y" : 536,
      "width" : 144,
      "height" : 36
    },
    "textPosition" : {
      "x" : 341,
      "y" : 543
    },
    "connectors" : [ {
      "edgeId" : 110561,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 468,
          "y" : 564
        },
        "to" : {
          "x" : 498,
          "y" : 570
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110564,
    "reactomeId" : 10308570,
    "displayName" : "DAB2,LDLRAP1:LDLR:LDL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 609,
      "y" : 580
    },
    "minX" : 551,
    "maxX" : 674,
    "minY" : 549,
    "maxY" : 605,
    "prop" : {
      "x" : 551,
      "y" : 555,
      "width" : 117,
      "height" : 50
    },
    "textPosition" : {
      "x" : 558,
      "y" : 570
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 668,
          "y" : 555
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 668,
          "y" : 555
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110561,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110567,
    "reactomeId" : 10308602,
    "displayName" : "NEDD8-STONs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 592,
      "y" : 135
    },
    "minX" : 539,
    "maxX" : 631,
    "minY" : 119,
    "maxY" : 184,
    "prop" : {
      "x" : 553,
      "y" : 119,
      "width" : 78,
      "height" : 32
    },
    "textPosition" : {
      "x" : 564,
      "y" : 118
    },
    "connectors" : [ {
      "edgeId" : 110565,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110568,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 574,
          "y" : 157
        },
        "to" : {
          "x" : 539,
          "y" : 184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110566,
    "reactomeId" : 10296039,
    "displayName" : "NEDD8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 835,
      "y" : 143
    },
    "minX" : 726,
    "maxX" : 889,
    "minY" : 119,
    "maxY" : 249,
    "prop" : {
      "x" : 787,
      "y" : 125,
      "width" : 96,
      "height" : 36
    },
    "textPosition" : {
      "x" : 809,
      "y" : 132
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 883,
          "y" : 125
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 883,
          "y" : 125
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110565,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 784,
          "y" : 136
        },
        "to" : {
          "x" : 726,
          "y" : 129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110572,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 827,
          "y" : 164
        },
        "to" : {
          "x" : 788,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 828,
          "y" : 172
        },
        "b" : {
          "x" : 827,
          "y" : 164
        },
        "c" : {
          "x" : 820,
          "y" : 169
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 820,
          "y" : 169
        }
      }
    } ]
  }, {
    "id" : 110569,
    "reactomeId" : 10308638,
    "displayName" : "COP9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 634,
      "y" : 184
    },
    "minX" : 539,
    "maxX" : 788,
    "minY" : 163,
    "maxY" : 249,
    "prop" : {
      "x" : 605,
      "y" : 169,
      "width" : 58,
      "height" : 30
    },
    "textPosition" : {
      "x" : 613,
      "y" : 178
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 663,
          "y" : 169
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 663,
          "y" : 169
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110568,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 602,
          "y" : 184
        },
        "to" : {
          "x" : 539,
          "y" : 184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110572,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 666,
          "y" : 196
        },
        "to" : {
          "x" : 788,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 674,
          "y" : 195
        },
        "b" : {
          "x" : 666,
          "y" : 196
        },
        "c" : {
          "x" : 671,
          "y" : 202
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 671,
          "y" : 202
        }
      }
    } ]
  }, {
    "id" : 110571,
    "reactomeId" : 10308640,
    "displayName" : "NEDD8-STONs:TOR1 hexamer:COP9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 405,
      "y" : 187
    },
    "minX" : 348,
    "maxX" : 500,
    "minY" : 156,
    "maxY" : 272,
    "prop" : {
      "x" : 348,
      "y" : 162,
      "width" : 114,
      "height" : 50
    },
    "textPosition" : {
      "x" : 354,
      "y" : 163
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 462,
          "y" : 162
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 462,
          "y" : 162
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110568,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110572,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110572,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 419,
          "y" : 215
        },
        "to" : {
          "x" : 453,
          "y" : 270
        }
      }, {
        "from" : {
          "x" : 453,
          "y" : 270
        },
        "to" : {
          "x" : 492,
          "y" : 269
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 496,
          "y" : 268
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 496,
          "y" : 268
        }
      }
    } ]
  }, {
    "id" : 110570,
    "reactomeId" : 10308616,
    "displayName" : "TOR1 hexamer",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 566,
      "y" : 226
    },
    "minX" : 523,
    "maxX" : 788,
    "minY" : 184,
    "maxY" : 249,
    "prop" : {
      "x" : 523,
      "y" : 208,
      "width" : 87,
      "height" : 37
    },
    "textPosition" : {
      "x" : 535,
      "y" : 209
    },
    "connectors" : [ {
      "edgeId" : 110568,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 554,
          "y" : 202
        },
        "to" : {
          "x" : 539,
          "y" : 184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110572,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 616,
          "y" : 230
        },
        "to" : {
          "x" : 788,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 623,
          "y" : 227
        },
        "b" : {
          "x" : 616,
          "y" : 230
        },
        "c" : {
          "x" : 622,
          "y" : 235
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 622,
          "y" : 235
        }
      }
    } ]
  }, {
    "id" : 110575,
    "reactomeId" : 10308590,
    "displayName" : "AGFG1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 90,
      "y" : 506
    },
    "minX" : 61,
    "maxX" : 170,
    "minY" : 488,
    "maxY" : 573,
    "prop" : {
      "x" : 61,
      "y" : 494,
      "width" : 59,
      "height" : 25
    },
    "textPosition" : {
      "x" : 66,
      "y" : 496
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 120,
          "y" : 494
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 120,
          "y" : 494
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110573,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 104,
          "y" : 522
        },
        "to" : {
          "x" : 170,
          "y" : 573
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110574,
    "reactomeId" : 10250064,
    "displayName" : "VAMP7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 87,
      "y" : 583
    },
    "minX" : 54,
    "maxX" : 170,
    "minY" : 562,
    "maxY" : 599,
    "prop" : {
      "x" : 54,
      "y" : 568,
      "width" : 66,
      "height" : 31
    },
    "textPosition" : {
      "x" : 62,
      "y" : 573
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 120,
          "y" : 568
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 120,
          "y" : 568
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110573,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 123,
          "y" : 579
        },
        "to" : {
          "x" : 170,
          "y" : 573
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110576,
    "reactomeId" : 10308592,
    "displayName" : "AGFG1:VAMP7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 261,
      "y" : 585
    },
    "minX" : 222,
    "maxX" : 306,
    "minY" : 558,
    "maxY" : 606,
    "prop" : {
      "x" : 222,
      "y" : 564,
      "width" : 78,
      "height" : 42
    },
    "textPosition" : {
      "x" : 234,
      "y" : 571
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 300,
          "y" : 564
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 300,
          "y" : 564
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110573,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110579,
    "reactomeId" : 10290684,
    "displayName" : "ARRB",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1255,
      "y" : 513
    },
    "minX" : 1227,
    "maxX" : 1284,
    "minY" : 498,
    "maxY" : 577,
    "prop" : {
      "x" : 1227,
      "y" : 498,
      "width" : 57,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1235,
      "y" : 502
    },
    "connectors" : [ {
      "edgeId" : 110577,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1258,
          "y" : 534
        },
        "to" : {
          "x" : 1268,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110578,
    "reactomeId" : 10309150,
    "displayName" : "ARRB-binding GPCRs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1189,
      "y" : 579
    },
    "minX" : 1140,
    "maxX" : 1268,
    "minY" : 561,
    "maxY" : 597,
    "prop" : {
      "x" : 1140,
      "y" : 561,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1142,
      "y" : 561
    },
    "connectors" : [ {
      "edgeId" : 110577,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1244,
          "y" : 577
        },
        "to" : {
          "x" : 1268,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110580,
    "reactomeId" : 10309152,
    "displayName" : "ARRB:ARRB-binding GPCRs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1377,
      "y" : 588
    },
    "minX" : 1323,
    "maxX" : 1542,
    "minY" : 526,
    "maxY" : 612,
    "prop" : {
      "x" : 1323,
      "y" : 565,
      "width" : 109,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1328,
      "y" : 577
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1432,
          "y" : 565
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1432,
          "y" : 565
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110577,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 110585,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1435,
          "y" : 567
        },
        "to" : {
          "x" : 1542,
          "y" : 526
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110583,
    "reactomeId" : 10309207,
    "displayName" : "EPS15,EPN1,EPN2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1546,
      "y" : 90
    },
    "minX" : 1489,
    "maxX" : 1604,
    "minY" : 27,
    "maxY" : 101,
    "prop" : {
      "x" : 1489,
      "y" : 79,
      "width" : 115,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1502,
      "y" : 73
    },
    "connectors" : [ {
      "edgeId" : 110581,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1554,
          "y" : 73
        },
        "to" : {
          "x" : 1597,
          "y" : 27
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110582,
    "reactomeId" : 10309199,
    "displayName" : "ubiquitinated cargo",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1487,
      "y" : 31
    },
    "minX" : 1427,
    "maxX" : 1597,
    "minY" : 20,
    "maxY" : 42,
    "prop" : {
      "x" : 1427,
      "y" : 20,
      "width" : 121,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1440,
      "y" : 14
    },
    "connectors" : [ {
      "edgeId" : 110581,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1554,
          "y" : 28
        },
        "to" : {
          "x" : 1597,
          "y" : 27
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110584,
    "reactomeId" : 10309209,
    "displayName" : "EPS15,EPN1,EPN2:ubiquitinated cargo",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1707,
      "y" : 31
    },
    "minX" : 1647,
    "maxX" : 1774,
    "minY" : 3,
    "maxY" : 53,
    "prop" : {
      "x" : 1647,
      "y" : 9,
      "width" : 121,
      "height" : 44
    },
    "textPosition" : {
      "x" : 1660,
      "y" : -10
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1768,
          "y" : 9
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1768,
          "y" : 9
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110581,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110587,
    "reactomeId" : 10309213,
    "displayName" : "ARBBs:ARBB-binding GPCRs:clathrin-coated pit",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1756,
      "y" : 592
    },
    "minX" : 1694,
    "maxX" : 1825,
    "minY" : 561,
    "maxY" : 618,
    "prop" : {
      "x" : 1694,
      "y" : 567,
      "width" : 125,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1695,
      "y" : 569
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1819,
          "y" : 567
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1819,
          "y" : 567
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110585,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110586,
    "reactomeId" : 10308230,
    "displayName" : "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1581,
      "y" : 586
    },
    "minX" : 1509,
    "maxX" : 1660,
    "minY" : 526,
    "maxY" : 621,
    "prop" : {
      "x" : 1509,
      "y" : 551,
      "width" : 145,
      "height" : 70
    },
    "textPosition" : {
      "x" : 1513,
      "y" : 558
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1654,
          "y" : 551
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1654,
          "y" : 551
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110585,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1558,
          "y" : 548
        },
        "to" : {
          "x" : 1542,
          "y" : 526
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110589,
    "reactomeId" : 10250444,
    "displayName" : "AVPR2:AVP(20-28)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 812,
      "y" : 577
    },
    "minX" : 771,
    "maxX" : 887,
    "minY" : 548,
    "maxY" : 600,
    "prop" : {
      "x" : 771,
      "y" : 554,
      "width" : 83,
      "height" : 46
    },
    "textPosition" : {
      "x" : 774,
      "y" : 565
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 854,
          "y" : 554
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 854,
          "y" : 554
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110588,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 857,
          "y" : 577
        },
        "to" : {
          "x" : 887,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 110591,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 972,
      "y" : 512
    },
    "minX" : 935,
    "maxX" : 994,
    "minY" : 496,
    "maxY" : 579,
    "prop" : {
      "x" : 952,
      "y" : 497,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 956,
      "y" : 501
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 988,
          "y" : 502
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 988,
          "y" : 502
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110588,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 963,
          "y" : 530
        },
        "to" : {
          "x" : 935,
          "y" : 579
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 963,
          "y" : 538
        },
        "b" : {
          "x" : 963,
          "y" : 530
        },
        "c" : {
          "x" : 956,
          "y" : 534
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 956,
          "y" : 534
        }
      }
    } ]
  }, {
    "id" : 110590,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 851,
      "y" : 529
    },
    "minX" : 831,
    "maxX" : 887,
    "minY" : 513,
    "maxY" : 577,
    "prop" : {
      "x" : 831,
      "y" : 514,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 835,
      "y" : 518
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 866,
          "y" : 519
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 866,
          "y" : 519
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 110588,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 862,
          "y" : 547
        },
        "to" : {
          "x" : 887,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 110561,
    "reactomeId" : 10308572,
    "displayName" : "LDLR is bound by DAB2 and ARH",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 523,
      "y" : 577
    },
    "minX" : 498,
    "maxX" : 548,
    "minY" : 570,
    "maxY" : 583,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 498,
        "y" : 570
      },
      "to" : {
        "x" : 523,
        "y" : 577
      }
    }, {
      "from" : {
        "x" : 523,
        "y" : 577
      },
      "to" : {
        "x" : 548,
        "y" : 577
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 541,
        "y" : 581
      },
      "b" : {
        "x" : 548,
        "y" : 577
      },
      "c" : {
        "x" : 541,
        "y" : 573
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 541,
        "y" : 573
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 523,
        "y" : 577
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 523,
        "y" : 577
      }
    },
    "inputs" : [ {
      "id" : 110562,
      "points" : [ {
        "x" : 468,
        "y" : 564
      } ]
    }, {
      "id" : 110563,
      "points" : [ {
        "x" : 448,
        "y" : 585
      } ]
    } ],
    "outputs" : [ {
      "id" : 110564
    } ]
  }, {
    "id" : 110594,
    "reactomeId" : 10309421,
    "displayName" : "PICALM binds R-SNAREs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2003,
      "y" : 29
    },
    "minX" : 1974,
    "maxX" : 2039,
    "minY" : 23,
    "maxY" : 35,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1974,
        "y" : 28
      },
      "to" : {
        "x" : 2003,
        "y" : 29
      }
    }, {
      "from" : {
        "x" : 2003,
        "y" : 29
      },
      "to" : {
        "x" : 2039,
        "y" : 28
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2032,
        "y" : 32
      },
      "b" : {
        "x" : 2039,
        "y" : 28
      },
      "c" : {
        "x" : 2032,
        "y" : 24
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2032,
        "y" : 24
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2003,
        "y" : 29
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2003,
        "y" : 29
      }
    },
    "inputs" : [ {
      "id" : 110595,
      "points" : [ {
        "x" : 1944,
        "y" : 61
      } ]
    }, {
      "id" : 110596,
      "points" : [ {
        "x" : 1946,
        "y" : 27
      } ]
    } ],
    "outputs" : [ {
      "id" : 110597
    } ]
  }, {
    "id" : 110565,
    "reactomeId" : 10308647,
    "displayName" : "STON2 is neddylated",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 687,
      "y" : 131
    },
    "minX" : 637,
    "maxX" : 726,
    "minY" : 125,
    "maxY" : 137,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 726,
        "y" : 129
      },
      "to" : {
        "x" : 687,
        "y" : 131
      }
    }, {
      "from" : {
        "x" : 687,
        "y" : 131
      },
      "to" : {
        "x" : 637,
        "y" : 133
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 644,
        "y" : 129
      },
      "b" : {
        "x" : 637,
        "y" : 133
      },
      "c" : {
        "x" : 644,
        "y" : 137
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 644,
        "y" : 137
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 681,
        "y" : 125
      },
      "b" : {
        "x" : 693,
        "y" : 137
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 687,
        "y" : 131
      }
    },
    "inputs" : [ {
      "id" : 110558,
      "points" : [ {
        "x" : 736,
        "y" : 92
      } ]
    }, {
      "id" : 110566,
      "points" : [ {
        "x" : 784,
        "y" : 136
      } ]
    } ],
    "outputs" : [ {
      "id" : 110567
    } ]
  }, {
    "id" : 110598,
    "reactomeId" : 10320227,
    "displayName" : "AP2 binds chlorpromazine",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 200,
      "y" : 128
    },
    "minX" : 194,
    "maxX" : 206,
    "minY" : 111,
    "maxY" : 151,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 200,
        "y" : 145
      },
      "to" : {
        "x" : 200,
        "y" : 128
      }
    }, {
      "from" : {
        "x" : 200,
        "y" : 128
      },
      "to" : {
        "x" : 200,
        "y" : 111
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 204,
        "y" : 118
      },
      "b" : {
        "x" : 200,
        "y" : 111
      },
      "c" : {
        "x" : 196,
        "y" : 118
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 196,
        "y" : 118
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 200,
        "y" : 128
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 200,
        "y" : 128
      }
    },
    "inputs" : [ {
      "id" : 110599,
      "points" : [ {
        "x" : 117,
        "y" : 114
      } ]
    }, {
      "id" : 110600,
      "points" : [ {
        "x" : 130,
        "y" : 173
      } ]
    } ],
    "outputs" : [ {
      "id" : 110601
    } ]
  }, {
    "id" : 110568,
    "reactomeId" : 10308642,
    "displayName" : "NEDD8-STON binds TOR1 hexamer and COP9 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 506,
      "y" : 182
    },
    "minX" : 465,
    "maxX" : 539,
    "minY" : 176,
    "maxY" : 188,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 539,
        "y" : 184
      },
      "to" : {
        "x" : 506,
        "y" : 182
      }
    }, {
      "from" : {
        "x" : 506,
        "y" : 182
      },
      "to" : {
        "x" : 465,
        "y" : 184
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 472,
        "y" : 180
      },
      "b" : {
        "x" : 465,
        "y" : 184
      },
      "c" : {
        "x" : 472,
        "y" : 188
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 472,
        "y" : 188
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 506,
        "y" : 182
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 506,
        "y" : 182
      }
    },
    "inputs" : [ {
      "id" : 110567,
      "points" : [ {
        "x" : 574,
        "y" : 157
      } ]
    }, {
      "id" : 110569,
      "points" : [ {
        "x" : 602,
        "y" : 184
      } ]
    }, {
      "id" : 110570,
      "points" : [ {
        "x" : 554,
        "y" : 202
      } ]
    } ],
    "outputs" : [ {
      "id" : 110571
    } ]
  }, {
    "id" : 110573,
    "reactomeId" : 10308594,
    "displayName" : "AGFG1 binds VAMP7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 194,
      "y" : 575
    },
    "minX" : 170,
    "maxX" : 219,
    "minY" : 569,
    "maxY" : 581,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 170,
        "y" : 573
      },
      "to" : {
        "x" : 194,
        "y" : 575
      }
    }, {
      "from" : {
        "x" : 194,
        "y" : 575
      },
      "to" : {
        "x" : 219,
        "y" : 579
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 212,
        "y" : 582
      },
      "b" : {
        "x" : 219,
        "y" : 579
      },
      "c" : {
        "x" : 213,
        "y" : 574
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 213,
        "y" : 574
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 194,
        "y" : 575
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 194,
        "y" : 575
      }
    },
    "inputs" : [ {
      "id" : 110574,
      "points" : [ {
        "x" : 123,
        "y" : 579
      } ]
    }, {
      "id" : 110575,
      "points" : [ {
        "x" : 104,
        "y" : 522
      } ]
    } ],
    "outputs" : [ {
      "id" : 110576
    } ]
  }, {
    "id" : 110572,
    "reactomeId" : 10308645,
    "displayName" : "COP9 and TOR1 deneddylate STON2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 508,
      "y" : 268
    },
    "minX" : 436,
    "maxX" : 788,
    "minY" : 215,
    "maxY" : 274,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 436,
        "y" : 215
      },
      "to" : {
        "x" : 508,
        "y" : 268
      }
    }, {
      "from" : {
        "x" : 508,
        "y" : 268
      },
      "to" : {
        "x" : 788,
        "y" : 249
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 502,
        "y" : 262
      },
      "b" : {
        "x" : 514,
        "y" : 274
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 508,
        "y" : 268
      }
    },
    "inputs" : [ {
      "id" : 110571
    } ],
    "outputs" : [ {
      "id" : 110558,
      "points" : [ {
        "x" : 742,
        "y" : 92
      } ]
    }, {
      "id" : 110566,
      "points" : [ {
        "x" : 827,
        "y" : 164
      } ]
    }, {
      "id" : 110569,
      "points" : [ {
        "x" : 666,
        "y" : 196
      } ]
    }, {
      "id" : 110570,
      "points" : [ {
        "x" : 616,
        "y" : 230
      } ]
    } ],
    "catalysts" : [ {
      "id" : 110571,
      "points" : [ {
        "x" : 419,
        "y" : 215
      }, {
        "x" : 453,
        "y" : 270
      } ]
    } ]
  }, {
    "id" : 110577,
    "reactomeId" : 10309154,
    "displayName" : "ARRB bind GPCRs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1291,
      "y" : 578
    },
    "minX" : 1268,
    "maxX" : 1320,
    "minY" : 572,
    "maxY" : 584,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1268,
        "y" : 577
      },
      "to" : {
        "x" : 1291,
        "y" : 578
      }
    }, {
      "from" : {
        "x" : 1291,
        "y" : 578
      },
      "to" : {
        "x" : 1320,
        "y" : 581
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1313,
        "y" : 584
      },
      "b" : {
        "x" : 1320,
        "y" : 581
      },
      "c" : {
        "x" : 1314,
        "y" : 576
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1314,
        "y" : 576
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1291,
        "y" : 578
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1291,
        "y" : 578
      }
    },
    "inputs" : [ {
      "id" : 110578,
      "points" : [ {
        "x" : 1244,
        "y" : 577
      } ]
    }, {
      "id" : 110579,
      "points" : [ {
        "x" : 1258,
        "y" : 534
      } ]
    } ],
    "outputs" : [ {
      "id" : 110580
    } ]
  }, {
    "id" : 110581,
    "reactomeId" : 10309211,
    "displayName" : "Epsin family proteins bind ubiquitinated cargo",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1621,
      "y" : 27
    },
    "minX" : 1597,
    "maxX" : 1644,
    "minY" : 21,
    "maxY" : 33,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1597,
        "y" : 27
      },
      "to" : {
        "x" : 1621,
        "y" : 27
      }
    }, {
      "from" : {
        "x" : 1621,
        "y" : 27
      },
      "to" : {
        "x" : 1644,
        "y" : 28
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1637,
        "y" : 32
      },
      "b" : {
        "x" : 1644,
        "y" : 28
      },
      "c" : {
        "x" : 1637,
        "y" : 24
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1637,
        "y" : 24
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1621,
        "y" : 27
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1621,
        "y" : 27
      }
    },
    "inputs" : [ {
      "id" : 110582,
      "points" : [ {
        "x" : 1554,
        "y" : 28
      } ]
    }, {
      "id" : 110583,
      "points" : [ {
        "x" : 1554,
        "y" : 73
      } ]
    } ],
    "outputs" : [ {
      "id" : 110584
    } ]
  }, {
    "id" : 110585,
    "reactomeId" : 10309215,
    "displayName" : "ARBB recruits GPCRs into clathrin-coated pits",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1650,
      "y" : 486
    },
    "minX" : 1542,
    "maxX" : 1730,
    "minY" : 480,
    "maxY" : 564,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1542,
        "y" : 526
      },
      "to" : {
        "x" : 1650,
        "y" : 486
      }
    }, {
      "from" : {
        "x" : 1650,
        "y" : 486
      },
      "to" : {
        "x" : 1730,
        "y" : 564
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1722,
        "y" : 562
      },
      "b" : {
        "x" : 1730,
        "y" : 564
      },
      "c" : {
        "x" : 1728,
        "y" : 556
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1728,
        "y" : 556
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1650,
        "y" : 486
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1650,
        "y" : 486
      }
    },
    "inputs" : [ {
      "id" : 110586,
      "points" : [ {
        "x" : 1558,
        "y" : 548
      } ]
    }, {
      "id" : 110580,
      "points" : [ {
        "x" : 1435,
        "y" : 567
      } ]
    } ],
    "outputs" : [ {
      "id" : 110587
    } ]
  }, {
    "id" : 110553,
    "reactomeId" : 10308576,
    "displayName" : "DAB2 binds LRP2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1212,
      "y" : 34
    },
    "minX" : 1181,
    "maxX" : 1239,
    "minY" : 28,
    "maxY" : 40,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1181,
        "y" : 33
      },
      "to" : {
        "x" : 1212,
        "y" : 34
      }
    }, {
      "from" : {
        "x" : 1212,
        "y" : 34
      },
      "to" : {
        "x" : 1239,
        "y" : 33
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1232,
        "y" : 37
      },
      "b" : {
        "x" : 1239,
        "y" : 33
      },
      "c" : {
        "x" : 1232,
        "y" : 29
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1232,
        "y" : 29
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1212,
        "y" : 34
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1212,
        "y" : 34
      }
    },
    "inputs" : [ {
      "id" : 110554,
      "points" : [ {
        "x" : 1142,
        "y" : 71
      } ]
    }, {
      "id" : 110555,
      "points" : [ {
        "x" : 1139,
        "y" : 32
      } ]
    } ],
    "outputs" : [ {
      "id" : 110556
    } ]
  }, {
    "id" : 110557,
    "reactomeId" : 10308564,
    "displayName" : "STON2 binds SYT proteins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 810,
      "y" : 33
    },
    "minX" : 768,
    "maxX" : 848,
    "minY" : 27,
    "maxY" : 39,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 768,
        "y" : 32
      },
      "to" : {
        "x" : 810,
        "y" : 33
      }
    }, {
      "from" : {
        "x" : 810,
        "y" : 33
      },
      "to" : {
        "x" : 848,
        "y" : 31
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 841,
        "y" : 35
      },
      "b" : {
        "x" : 848,
        "y" : 31
      },
      "c" : {
        "x" : 841,
        "y" : 27
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 841,
        "y" : 27
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 810,
        "y" : 33
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 810,
        "y" : 33
      }
    },
    "inputs" : [ {
      "id" : 110558,
      "points" : [ {
        "x" : 746,
        "y" : 58
      } ]
    }, {
      "id" : 110559,
      "points" : [ {
        "x" : 713,
        "y" : 30
      } ]
    } ],
    "outputs" : [ {
      "id" : 110560
    } ]
  }, {
    "id" : 110588,
    "reactomeId" : 10309148,
    "displayName" : "ADBRK1,2 phosphorylate AVPR2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 909,
      "y" : 579
    },
    "minX" : 887,
    "maxX" : 935,
    "minY" : 573,
    "maxY" : 585,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 887,
        "y" : 577
      },
      "to" : {
        "x" : 909,
        "y" : 579
      }
    }, {
      "from" : {
        "x" : 909,
        "y" : 579
      },
      "to" : {
        "x" : 935,
        "y" : 579
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 903,
        "y" : 573
      },
      "b" : {
        "x" : 915,
        "y" : 585
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 909,
        "y" : 579
      }
    },
    "inputs" : [ {
      "id" : 110589,
      "points" : [ {
        "x" : 857,
        "y" : 577
      } ]
    }, {
      "id" : 110590,
      "points" : [ {
        "x" : 862,
        "y" : 547
      } ]
    } ],
    "outputs" : [ {
      "id" : 110591,
      "points" : [ {
        "x" : 963,
        "y" : 530
      } ]
    }, {
      "id" : 110592,
      "points" : [ {
        "x" : 966,
        "y" : 579
      } ]
    } ],
    "catalysts" : [ {
      "id" : 110593,
      "points" : [ {
        "x" : 893,
        "y" : 503
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 110602,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1148,
      "y" : 306
    },
    "minX" : 0,
    "maxX" : 2296,
    "minY" : 13,
    "maxY" : 599,
    "prop" : {
      "x" : 0,
      "y" : 13,
      "width" : 2296,
      "height" : 586
    },
    "textPosition" : {
      "x" : 867,
      "y" : 292
    },
    "insets" : {
      "x" : 10,
      "y" : 23,
      "width" : 2276,
      "height" : 566
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 110558, 110559, 110554, 110564, 110562, 110556, 110557, 110560, 110563, 110555, 110567, 110565, 110566, 110568, 110569, 110570, 110571, 110572, 110553, 110575, 110576, 110573, 110599, 110578, 110579, 110580, 110577, 110582, 110583, 110584, 110581, 110585, 110587, 110589, 110590, 110591, 110592, 110605, 110593, 110561, 110588, 110595, 110596, 110597, 110594, 110604, 110574, 110586, 110606, 110607, 110608, 110609, 110610, 110611, 110612, 110613, 110601, 110598, 110600 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 110609,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1326,
      "y" : 212
    },
    "minX" : 1292,
    "maxX" : 2174,
    "minY" : 53,
    "maxY" : 394,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1292,
        "y" : 53
      },
      "to" : {
        "x" : 1326,
        "y" : 212
      }
    }, {
      "from" : {
        "x" : 1326,
        "y" : 212
      },
      "to" : {
        "x" : 2174,
        "y" : 394
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2166,
        "y" : 396
      },
      "b" : {
        "x" : 2174,
        "y" : 394
      },
      "c" : {
        "x" : 2168,
        "y" : 389
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2168,
        "y" : 389
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1320,
        "y" : 206
      },
      "b" : {
        "x" : 1332,
        "y" : 218
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1326,
        "y" : 212
      }
    },
    "inputs" : [ {
      "id" : 110556
    } ],
    "outputs" : [ {
      "id" : 110604
    } ]
  }, {
    "id" : 110608,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1976,
      "y" : 215
    },
    "minX" : 1739,
    "maxX" : 2213,
    "minY" : 56,
    "maxY" : 375,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1739,
        "y" : 56
      },
      "to" : {
        "x" : 2213,
        "y" : 375
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2205,
        "y" : 374
      },
      "b" : {
        "x" : 2213,
        "y" : 375
      },
      "c" : {
        "x" : 2209,
        "y" : 368
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2209,
        "y" : 368
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1970,
        "y" : 209
      },
      "b" : {
        "x" : 1982,
        "y" : 221
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1976,
        "y" : 215
      }
    },
    "inputs" : [ {
      "id" : 110584
    } ],
    "outputs" : [ {
      "id" : 110604
    } ]
  }, {
    "id" : 110611,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1347,
      "y" : 294
    },
    "minX" : 947,
    "maxX" : 2174,
    "minY" : 49,
    "maxY" : 401,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 947,
        "y" : 49
      },
      "to" : {
        "x" : 1347,
        "y" : 294
      }
    }, {
      "from" : {
        "x" : 1347,
        "y" : 294
      },
      "to" : {
        "x" : 2174,
        "y" : 401
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2167,
        "y" : 404
      },
      "b" : {
        "x" : 2174,
        "y" : 401
      },
      "c" : {
        "x" : 2168,
        "y" : 396
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2168,
        "y" : 396
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1341,
        "y" : 288
      },
      "b" : {
        "x" : 1353,
        "y" : 300
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1347,
        "y" : 294
      }
    },
    "inputs" : [ {
      "id" : 110560
    } ],
    "outputs" : [ {
      "id" : 110604
    } ]
  }, {
    "id" : 110610,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 675,
      "y" : 417
    },
    "minX" : 619,
    "maxX" : 2174,
    "minY" : 411,
    "maxY" : 552,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 619,
        "y" : 552
      },
      "to" : {
        "x" : 675,
        "y" : 417
      }
    }, {
      "from" : {
        "x" : 675,
        "y" : 417
      },
      "to" : {
        "x" : 2174,
        "y" : 413
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2167,
        "y" : 417
      },
      "b" : {
        "x" : 2174,
        "y" : 413
      },
      "c" : {
        "x" : 2167,
        "y" : 409
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2167,
        "y" : 409
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 669,
        "y" : 411
      },
      "b" : {
        "x" : 681,
        "y" : 423
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 675,
        "y" : 417
      }
    },
    "inputs" : [ {
      "id" : 110564
    } ],
    "outputs" : [ {
      "id" : 110604
    } ]
  }, {
    "id" : 110613,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1537,
      "y" : 445
    },
    "minX" : 1403,
    "maxX" : 2174,
    "minY" : 416,
    "maxY" : 562,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1403,
        "y" : 562
      },
      "to" : {
        "x" : 1537,
        "y" : 445
      }
    }, {
      "from" : {
        "x" : 1537,
        "y" : 445
      },
      "to" : {
        "x" : 2174,
        "y" : 416
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2167,
        "y" : 420
      },
      "b" : {
        "x" : 2174,
        "y" : 416
      },
      "c" : {
        "x" : 2167,
        "y" : 412
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2167,
        "y" : 412
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1531,
        "y" : 439
      },
      "b" : {
        "x" : 1543,
        "y" : 451
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1537,
        "y" : 445
      }
    },
    "inputs" : [ {
      "id" : 110580
    } ],
    "outputs" : [ {
      "id" : 110604
    } ]
  }, {
    "id" : 110612,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 390,
      "y" : 362
    },
    "minX" : 273,
    "maxX" : 2174,
    "minY" : 356,
    "maxY" : 561,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 273,
        "y" : 561
      },
      "to" : {
        "x" : 390,
        "y" : 362
      }
    }, {
      "from" : {
        "x" : 390,
        "y" : 362
      },
      "to" : {
        "x" : 2174,
        "y" : 410
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2167,
        "y" : 414
      },
      "b" : {
        "x" : 2174,
        "y" : 410
      },
      "c" : {
        "x" : 2167,
        "y" : 406
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2167,
        "y" : 406
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 384,
        "y" : 356
      },
      "b" : {
        "x" : 396,
        "y" : 368
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 390,
        "y" : 362
      }
    },
    "inputs" : [ {
      "id" : 110576
    } ],
    "outputs" : [ {
      "id" : 110604
    } ]
  }, {
    "id" : 110605,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1111,
      "y" : 578
    },
    "minX" : 1089,
    "maxX" : 1134,
    "minY" : 572,
    "maxY" : 584,
    "segments" : [ {
      "from" : {
        "x" : 1089,
        "y" : 578
      },
      "to" : {
        "x" : 1134,
        "y" : 578
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1105,
        "y" : 572
      },
      "b" : {
        "x" : 1117,
        "y" : 584
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1111,
        "y" : 578
      }
    },
    "inputs" : [ {
      "id" : 110592
    } ],
    "outputs" : [ {
      "id" : 110578
    } ]
  }, {
    "id" : 110607,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2174,
      "y" : 214
    },
    "minX" : 2100,
    "maxX" : 2248,
    "minY" : 53,
    "maxY" : 375,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2100,
        "y" : 53
      },
      "to" : {
        "x" : 2248,
        "y" : 375
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2241,
        "y" : 370
      },
      "b" : {
        "x" : 2248,
        "y" : 375
      },
      "c" : {
        "x" : 2249,
        "y" : 367
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2249,
        "y" : 367
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2168,
        "y" : 208
      },
      "b" : {
        "x" : 2180,
        "y" : 220
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2174,
        "y" : 214
      }
    },
    "inputs" : [ {
      "id" : 110597
    } ],
    "outputs" : [ {
      "id" : 110604
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 2353,
  "minY" : 0,
  "maxY" : 621,
  "disease" : false
}