{
  "dbId" : 10331123,
  "stableId" : "R-CFA-8981607",
  "displayName" : "Intracellular oxygen transport",
  "nodes" : [ {
    "id" : 98161,
    "reactomeId" : 10315140,
    "displayName" : "MB:ferroheme b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 104,
      "y" : 59
    },
    "minX" : 41,
    "maxX" : 191,
    "minY" : 41,
    "maxY" : 133,
    "prop" : {
      "x" : 41,
      "y" : 47,
      "width" : 126,
      "height" : 25
    },
    "textPosition" : {
      "x" : 50,
      "y" : 51
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 167,
          "y" : 47
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 167,
          "y" : 47
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 98163,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 118,
          "y" : 75
        },
        "to" : {
          "x" : 191,
          "y" : 133
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 126,
          "y" : 76
        },
        "b" : {
          "x" : 118,
          "y" : 75
        },
        "c" : {
          "x" : 121,
          "y" : 82
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 121,
          "y" : 82
        }
      }
    }, {
      "edgeId" : 98159,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 114,
          "y" : 75
        },
        "to" : {
          "x" : 168,
          "y" : 132
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 98160,
    "reactomeId" : 29368,
    "displayName" : "O2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 341,
      "y" : 34
    },
    "minX" : 168,
    "maxX" : 598,
    "minY" : 18,
    "maxY" : 133,
    "prop" : {
      "x" : 318,
      "y" : 19,
      "width" : 47,
      "height" : 30
    },
    "textPosition" : {
      "x" : 329,
      "y" : 23
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 360,
          "y" : 24
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 360,
          "y" : 24
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 98163,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 318,
          "y" : 52
        },
        "to" : {
          "x" : 191,
          "y" : 133
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 314,
          "y" : 59
        },
        "b" : {
          "x" : 318,
          "y" : 52
        },
        "c" : {
          "x" : 310,
          "y" : 52
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 310,
          "y" : 52
        }
      }
    }, {
      "edgeId" : 98164,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 368,
          "y" : 40
        },
        "to" : {
          "x" : 576,
          "y" : 103
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 466,
            "y" : 65
          },
          "b" : {
            "x" : 478,
            "y" : 77
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 472,
            "y" : 71
          }
        }
      }
    }, {
      "edgeId" : 98167,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 368,
          "y" : 39
        },
        "to" : {
          "x" : 598,
          "y" : 99
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 477,
            "y" : 63
          },
          "b" : {
            "x" : 489,
            "y" : 75
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 483,
            "y" : 69
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 376,
          "y" : 37
        },
        "b" : {
          "x" : 368,
          "y" : 39
        },
        "c" : {
          "x" : 374,
          "y" : 45
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 374,
          "y" : 45
        }
      }
    }, {
      "edgeId" : 98159,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 315,
          "y" : 47
        },
        "to" : {
          "x" : 168,
          "y" : 132
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 98162,
    "reactomeId" : 10315142,
    "displayName" : "MB:ferroheme b:O2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 177,
      "y" : 285
    },
    "minX" : 105,
    "maxX" : 256,
    "minY" : 265,
    "maxY" : 299,
    "prop" : {
      "x" : 105,
      "y" : 271,
      "width" : 145,
      "height" : 28
    },
    "textPosition" : {
      "x" : 113,
      "y" : 278
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 250,
          "y" : 271
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 250,
          "y" : 271
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 98163,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 98159,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 98165,
    "reactomeId" : 10287594,
    "displayName" : "CYGB(Fe2+) dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 643,
      "y" : 51
    },
    "minX" : 576,
    "maxX" : 693,
    "minY" : 34,
    "maxY" : 103,
    "prop" : {
      "x" : 599,
      "y" : 40,
      "width" : 88,
      "height" : 22
    },
    "textPosition" : {
      "x" : 599,
      "y" : 27
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 687,
          "y" : 40
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 687,
          "y" : 40
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 98164,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 628,
          "y" : 65
        },
        "to" : {
          "x" : 576,
          "y" : 103
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 98167,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 632,
          "y" : 65
        },
        "to" : {
          "x" : 598,
          "y" : 99
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 630,
          "y" : 73
        },
        "b" : {
          "x" : 632,
          "y" : 65
        },
        "c" : {
          "x" : 624,
          "y" : 67
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 624,
          "y" : 67
        }
      }
    } ]
  }, {
    "id" : 98166,
    "reactomeId" : 10287596,
    "displayName" : "CYGB dimer:O2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 588,
      "y" : 287
    },
    "minX" : 533,
    "maxX" : 649,
    "minY" : 270,
    "maxY" : 298,
    "prop" : {
      "x" : 533,
      "y" : 276,
      "width" : 110,
      "height" : 22
    },
    "textPosition" : {
      "x" : 538,
      "y" : 277
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 643,
          "y" : 276
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 643,
          "y" : 276
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 98164,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 98167,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 98163,
    "reactomeId" : 10315146,
    "displayName" : "Myoglobin:oxygen dissociates",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 190,
      "y" : 183
    },
    "minX" : 178,
    "maxX" : 196,
    "minY" : 133,
    "maxY" : 268,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 178,
        "y" : 268
      },
      "to" : {
        "x" : 190,
        "y" : 183
      }
    }, {
      "from" : {
        "x" : 190,
        "y" : 183
      },
      "to" : {
        "x" : 191,
        "y" : 133
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 190,
        "y" : 183
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 190,
        "y" : 183
      }
    },
    "inputs" : [ {
      "id" : 98162
    } ],
    "outputs" : [ {
      "id" : 98160,
      "points" : [ {
        "x" : 318,
        "y" : 52
      } ]
    }, {
      "id" : 98161,
      "points" : [ {
        "x" : 118,
        "y" : 75
      } ]
    } ]
  }, {
    "id" : 98164,
    "reactomeId" : 10287598,
    "displayName" : "CYGB binds O2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 578,
      "y" : 183
    },
    "minX" : 572,
    "maxX" : 586,
    "minY" : 103,
    "maxY" : 273,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 576,
        "y" : 103
      },
      "to" : {
        "x" : 578,
        "y" : 183
      }
    }, {
      "from" : {
        "x" : 578,
        "y" : 183
      },
      "to" : {
        "x" : 586,
        "y" : 273
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 581,
        "y" : 266
      },
      "b" : {
        "x" : 586,
        "y" : 273
      },
      "c" : {
        "x" : 589,
        "y" : 266
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 589,
        "y" : 266
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 578,
        "y" : 183
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 578,
        "y" : 183
      }
    },
    "inputs" : [ {
      "id" : 98160,
      "points" : [ {
        "x" : 368,
        "y" : 40
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 98165,
      "points" : [ {
        "x" : 628,
        "y" : 65
      } ]
    } ],
    "outputs" : [ {
      "id" : 98166
    } ]
  }, {
    "id" : 98167,
    "reactomeId" : 10315409,
    "displayName" : "CYGB:O2 dissociates",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 600,
      "y" : 186
    },
    "minX" : 589,
    "maxX" : 606,
    "minY" : 99,
    "maxY" : 273,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 589,
        "y" : 273
      },
      "to" : {
        "x" : 600,
        "y" : 186
      }
    }, {
      "from" : {
        "x" : 600,
        "y" : 186
      },
      "to" : {
        "x" : 598,
        "y" : 99
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 600,
        "y" : 186
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 600,
        "y" : 186
      }
    },
    "inputs" : [ {
      "id" : 98166
    } ],
    "outputs" : [ {
      "id" : 98160,
      "points" : [ {
        "x" : 368,
        "y" : 39
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 98165,
      "points" : [ {
        "x" : 632,
        "y" : 65
      } ]
    } ]
  }, {
    "id" : 98159,
    "reactomeId" : 10315144,
    "displayName" : "Myoglobin binds oxygen",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 168,
      "y" : 184
    },
    "minX" : 162,
    "maxX" : 175,
    "minY" : 132,
    "maxY" : 268,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 168,
        "y" : 132
      },
      "to" : {
        "x" : 168,
        "y" : 184
      }
    }, {
      "from" : {
        "x" : 168,
        "y" : 184
      },
      "to" : {
        "x" : 175,
        "y" : 268
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 170,
        "y" : 261
      },
      "b" : {
        "x" : 175,
        "y" : 268
      },
      "c" : {
        "x" : 178,
        "y" : 261
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 178,
        "y" : 261
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 168,
        "y" : 184
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 168,
        "y" : 184
      }
    },
    "inputs" : [ {
      "id" : 98160,
      "points" : [ {
        "x" : 315,
        "y" : 47
      } ]
    }, {
      "id" : 98161,
      "points" : [ {
        "x" : 114,
        "y" : 75
      } ]
    } ],
    "outputs" : [ {
      "id" : 98162
    } ]
  } ],
  "compartments" : [ {
    "id" : 98168,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 354,
      "y" : 177
    },
    "minX" : 0,
    "maxX" : 709,
    "minY" : 0,
    "maxY" : 355,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 709,
      "height" : 355
    },
    "textPosition" : {
      "x" : 27,
      "y" : 308
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 689,
      "height" : 335
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 98159, 98160, 98161, 98162, 98163, 98164, 98165, 98166, 98167 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 709,
  "minY" : 0,
  "maxY" : 355,
  "disease" : false
}