{
  "dbId" : 10330475,
  "stableId" : "R-CFA-512988",
  "displayName" : "Interleukin-3, Interleukin-5 and GM-CSF signaling",
  "nodes" : [ {
    "id" : 114945,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 222,
      "y" : 1158
    },
    "minX" : 175,
    "maxX" : 244,
    "minY" : 1142,
    "maxY" : 1195,
    "prop" : {
      "x" : 201,
      "y" : 1143,
      "width" : 42,
      "height" : 31
    },
    "textPosition" : {
      "x" : 206,
      "y" : 1148
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 238,
          "y" : 1148
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 238,
          "y" : 1148
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114944,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 202,
          "y" : 1177
        },
        "to" : {
          "x" : 175,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 182,
            "y" : 1180
          },
          "b" : {
            "x" : 194,
            "y" : 1192
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 188,
            "y" : 1186
          }
        }
      }
    } ]
  }, {
    "id" : 114947,
    "reactomeId" : 10260967,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 95,
      "y" : 1343
    },
    "minX" : 30,
    "maxX" : 176,
    "minY" : 1248,
    "maxY" : 1385,
    "prop" : {
      "x" : 30,
      "y" : 1302,
      "width" : 131,
      "height" : 83
    },
    "textPosition" : {
      "x" : 28,
      "y" : 1305
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114944,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 130,
          "y" : 1296
        },
        "to" : {
          "x" : 176,
          "y" : 1248
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 132,
          "y" : 1288
        },
        "b" : {
          "x" : 130,
          "y" : 1296
        },
        "c" : {
          "x" : 138,
          "y" : 1294
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 138,
          "y" : 1294
        }
      }
    }, {
      "edgeId" : 114948,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114946,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 228,
      "y" : 1280
    },
    "minX" : 176,
    "maxX" : 250,
    "minY" : 1248,
    "maxY" : 1296,
    "prop" : {
      "x" : 207,
      "y" : 1265,
      "width" : 42,
      "height" : 31
    },
    "textPosition" : {
      "x" : 211,
      "y" : 1270
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 244,
          "y" : 1270
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 244,
          "y" : 1270
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114944,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 204,
          "y" : 1267
        },
        "to" : {
          "x" : 176,
          "y" : 1248
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 184,
            "y" : 1251
          },
          "b" : {
            "x" : 196,
            "y" : 1263
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 190,
            "y" : 1257
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 196,
          "y" : 1266
        },
        "b" : {
          "x" : 204,
          "y" : 1267
        },
        "c" : {
          "x" : 201,
          "y" : 1260
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 201,
          "y" : 1260
        }
      }
    } ]
  }, {
    "id" : 114949,
    "reactomeId" : 10259018,
    "displayName" : "p-STAT5A, p-STAT5B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 219,
      "y" : 1340
    },
    "minX" : 4,
    "maxX" : 262,
    "minY" : 1155,
    "maxY" : 1355,
    "prop" : {
      "x" : 176,
      "y" : 1325,
      "width" : 86,
      "height" : 30
    },
    "textPosition" : {
      "x" : 176,
      "y" : 1323
    },
    "connectors" : [ {
      "edgeId" : 114948,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 201,
          "y" : 1319
        },
        "to" : {
          "x" : 4,
          "y" : 1155
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 96,
            "y" : 1231
          },
          "b" : {
            "x" : 108,
            "y" : 1243
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 102,
            "y" : 1237
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 193,
          "y" : 1318
        },
        "b" : {
          "x" : 201,
          "y" : 1319
        },
        "c" : {
          "x" : 198,
          "y" : 1311
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 198,
          "y" : 1311
        }
      }
    } ]
  }, {
    "id" : 114951,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1440,
      "y" : 175
    },
    "minX" : 1419,
    "maxX" : 1495,
    "minY" : 159,
    "maxY" : 207,
    "prop" : {
      "x" : 1419,
      "y" : 160,
      "width" : 42,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1424,
      "y" : 165
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1456,
          "y" : 165
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1456,
          "y" : 165
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114950,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1464,
          "y" : 187
        },
        "to" : {
          "x" : 1495,
          "y" : 207
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 1473,
            "y" : 191
          },
          "b" : {
            "x" : 1485,
            "y" : 203
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1479,
            "y" : 197
          }
        }
      }
    } ]
  }, {
    "id" : 114953,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1453,
      "y" : 317
    },
    "minX" : 1432,
    "maxX" : 1495,
    "minY" : 260,
    "maxY" : 333,
    "prop" : {
      "x" : 1432,
      "y" : 302,
      "width" : 42,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1436,
      "y" : 307
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1469,
          "y" : 307
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1469,
          "y" : 307
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114950,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1464,
          "y" : 299
        },
        "to" : {
          "x" : 1495,
          "y" : 260
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 1473,
            "y" : 273
          },
          "b" : {
            "x" : 1485,
            "y" : 285
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1479,
            "y" : 279
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1465,
          "y" : 291
        },
        "b" : {
          "x" : 1464,
          "y" : 299
        },
        "c" : {
          "x" : 1471,
          "y" : 296
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1471,
          "y" : 296
        }
      }
    } ]
  }, {
    "id" : 114952,
    "reactomeId" : 10260932,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1609,
      "y" : 303
    },
    "minX" : 355,
    "maxX" : 1692,
    "minY" : 260,
    "maxY" : 1443,
    "prop" : {
      "x" : 1527,
      "y" : 264,
      "width" : 165,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1526,
      "y" : 264
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114950,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1521,
          "y" : 271
        },
        "to" : {
          "x" : 1495,
          "y" : 260
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1513,
          "y" : 272
        },
        "b" : {
          "x" : 1521,
          "y" : 271
        },
        "c" : {
          "x" : 1516,
          "y" : 265
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1516,
          "y" : 265
        }
      }
    }, {
      "edgeId" : 114955,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1584,
          "y" : 348
        },
        "to" : {
          "x" : 1569,
          "y" : 367
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114979,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1521,
          "y" : 334
        },
        "to" : {
          "x" : 541,
          "y" : 712
        }
      }, {
        "from" : {
          "x" : 541,
          "y" : 712
        },
        "to" : {
          "x" : 545,
          "y" : 1335
        }
      }, {
        "from" : {
          "x" : 545,
          "y" : 1335
        },
        "to" : {
          "x" : 355,
          "y" : 1443
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114954,
    "reactomeId" : 10260944,
    "displayName" : "Tyrosine kinases that phosphorylate the Common beta chain",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1589,
      "y" : 163
    },
    "minX" : 1504,
    "maxX" : 1656,
    "minY" : 131,
    "maxY" : 235,
    "prop" : {
      "x" : 1523,
      "y" : 131,
      "width" : 133,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1523,
      "y" : 131
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114950,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1562,
          "y" : 201
        },
        "to" : {
          "x" : 1533,
          "y" : 230
        }
      }, {
        "from" : {
          "x" : 1533,
          "y" : 230
        },
        "to" : {
          "x" : 1512,
          "y" : 231
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1508,
          "y" : 231
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1508,
          "y" : 231
        }
      }
    } ]
  }, {
    "id" : 114957,
    "reactomeId" : 10260997,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1591,
      "y" : 490
    },
    "minX" : 1526,
    "maxX" : 1657,
    "minY" : 441,
    "maxY" : 539,
    "prop" : {
      "x" : 1526,
      "y" : 441,
      "width" : 131,
      "height" : 98
    },
    "textPosition" : {
      "x" : 1524,
      "y" : 444
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114955,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114956,
    "reactomeId" : 10231212,
    "displayName" : "SHC1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1508,
      "y" : 387
    },
    "minX" : 1484,
    "maxX" : 1569,
    "minY" : 366,
    "maxY" : 402,
    "prop" : {
      "x" : 1484,
      "y" : 373,
      "width" : 49,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1488,
      "y" : 377
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1533,
          "y" : 373
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1533,
          "y" : 373
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114955,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1536,
          "y" : 378
        },
        "to" : {
          "x" : 1569,
          "y" : 367
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1546,
            "y" : 366
          },
          "b" : {
            "x" : 1558,
            "y" : 378
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1552,
            "y" : 372
          }
        }
      }
    } ]
  }, {
    "id" : 114959,
    "reactomeId" : 10259098,
    "displayName" : "GRB2:GAB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1437,
      "y" : 817
    },
    "minX" : 1409,
    "maxX" : 1586,
    "minY" : 790,
    "maxY" : 838,
    "prop" : {
      "x" : 1409,
      "y" : 796,
      "width" : 57,
      "height" : 42
    },
    "textPosition" : {
      "x" : 1415,
      "y" : 803
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1466,
          "y" : 796
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1466,
          "y" : 796
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114958,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1469,
          "y" : 817
        },
        "to" : {
          "x" : 1586,
          "y" : 822
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1521,
            "y" : 813
          },
          "b" : {
            "x" : 1533,
            "y" : 825
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1527,
            "y" : 819
          }
        }
      }
    } ]
  }, {
    "id" : 114961,
    "reactomeId" : 10259120,
    "displayName" : "Interleukin receptor compexes with activated Shc:GRB2:GAB2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1631,
      "y" : 894
    },
    "minX" : 1555,
    "maxX" : 1708,
    "minY" : 862,
    "maxY" : 959,
    "prop" : {
      "x" : 1555,
      "y" : 862,
      "width" : 153,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1563,
      "y" : 862
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114958,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114962,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1612,
          "y" : 932
        },
        "to" : {
          "x" : 1594,
          "y" : 959
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114960,
    "reactomeId" : 10259096,
    "displayName" : "Interleukin receptor complexes with activated SHC1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1603,
      "y" : 765
    },
    "minX" : 1233,
    "maxX" : 1666,
    "minY" : 733,
    "maxY" : 1197,
    "prop" : {
      "x" : 1541,
      "y" : 733,
      "width" : 125,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1550,
      "y" : 733
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114958,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1593,
          "y" : 803
        },
        "to" : {
          "x" : 1586,
          "y" : 822
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114969,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1587,
          "y" : 803
        },
        "to" : {
          "x" : 1388,
          "y" : 1197
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114972,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1565,
          "y" : 803
        },
        "to" : {
          "x" : 1233,
          "y" : 1083
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114963,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1530,
      "y" : 960
    },
    "minX" : 1511,
    "maxX" : 1594,
    "minY" : 944,
    "maxY" : 976,
    "prop" : {
      "x" : 1511,
      "y" : 945,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1514,
      "y" : 950
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1544,
          "y" : 950
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1544,
          "y" : 950
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114962,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1552,
          "y" : 959
        },
        "to" : {
          "x" : 1594,
          "y" : 959
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1567,
            "y" : 953
          },
          "b" : {
            "x" : 1579,
            "y" : 965
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1573,
            "y" : 959
          }
        }
      }
    } ]
  }, {
    "id" : 114965,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1530,
      "y" : 999
    },
    "minX" : 1511,
    "maxX" : 1594,
    "minY" : 983,
    "maxY" : 1015,
    "prop" : {
      "x" : 1511,
      "y" : 984,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1514,
      "y" : 989
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1545,
          "y" : 989
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1545,
          "y" : 989
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114962,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1553,
          "y" : 998
        },
        "to" : {
          "x" : 1594,
          "y" : 998
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1567,
            "y" : 992
          },
          "b" : {
            "x" : 1579,
            "y" : 1004
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1573,
            "y" : 998
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1560,
          "y" : 994
        },
        "b" : {
          "x" : 1553,
          "y" : 998
        },
        "c" : {
          "x" : 1560,
          "y" : 1002
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1560,
          "y" : 1002
        }
      }
    } ]
  }, {
    "id" : 114964,
    "reactomeId" : 10259936,
    "displayName" : "Interleukin receptor complexes with activated Shc:GRB2:p-GAB2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1617,
      "y" : 1052
    },
    "minX" : 1541,
    "maxX" : 1694,
    "minY" : 998,
    "maxY" : 1110,
    "prop" : {
      "x" : 1541,
      "y" : 1020,
      "width" : 153,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1544,
      "y" : 1020
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114962,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1603,
          "y" : 1014
        },
        "to" : {
          "x" : 1594,
          "y" : 998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1596,
          "y" : 1010
        },
        "b" : {
          "x" : 1603,
          "y" : 1014
        },
        "c" : {
          "x" : 1603,
          "y" : 1006
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1603,
          "y" : 1006
        }
      }
    }, {
      "edgeId" : 114966,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1602,
          "y" : 1090
        },
        "to" : {
          "x" : 1591,
          "y" : 1110
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114967,
    "reactomeId" : 10259922,
    "displayName" : "p85-containing Class 1A PI3Ks",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1061,
      "y" : 929
    },
    "minX" : 206,
    "maxX" : 1591,
    "minY" : 362,
    "maxY" : 1625,
    "prop" : {
      "x" : 1008,
      "y" : 911,
      "width" : 107,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1008,
      "y" : 911
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114966,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1113,
          "y" : 953
        },
        "to" : {
          "x" : 1591,
          "y" : 1110
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1346,
            "y" : 1025
          },
          "b" : {
            "x" : 1358,
            "y" : 1037
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1352,
            "y" : 1031
          }
        }
      }
    }, {
      "edgeId" : 114992,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1033,
          "y" : 905
        },
        "to" : {
          "x" : 206,
          "y" : 362
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114994,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1048,
          "y" : 953
        },
        "to" : {
          "x" : 565,
          "y" : 1625
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114968,
    "reactomeId" : 10259948,
    "displayName" : "Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1594,
      "y" : 1233
    },
    "minX" : 1532,
    "maxX" : 1657,
    "minY" : 1184,
    "maxY" : 1282,
    "prop" : {
      "x" : 1532,
      "y" : 1184,
      "width" : 125,
      "height" : 98
    },
    "textPosition" : {
      "x" : 1531,
      "y" : 1181
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114966,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114971,
    "reactomeId" : 10259124,
    "displayName" : "Interleukin receptor complexes with activated SHC1:GRB2:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1592,
      "y" : 1376
    },
    "minX" : 1531,
    "maxX" : 1660,
    "minY" : 1335,
    "maxY" : 1411,
    "prop" : {
      "x" : 1531,
      "y" : 1341,
      "width" : 123,
      "height" : 70
    },
    "textPosition" : {
      "x" : 1539,
      "y" : 1334
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1654,
          "y" : 1341
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1654,
          "y" : 1341
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114969,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114970,
    "reactomeId" : 10231178,
    "displayName" : "GRB2-1:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1319,
      "y" : 1146
    },
    "minX" : 1268,
    "maxX" : 1388,
    "minY" : 1126,
    "maxY" : 1197,
    "prop" : {
      "x" : 1268,
      "y" : 1132,
      "width" : 103,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1274,
      "y" : 1140
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1371,
          "y" : 1132
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1371,
          "y" : 1132
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114969,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1338,
          "y" : 1164
        },
        "to" : {
          "x" : 1388,
          "y" : 1197
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1357,
            "y" : 1174
          },
          "b" : {
            "x" : 1369,
            "y" : 1186
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1363,
            "y" : 1180
          }
        }
      }
    } ]
  }, {
    "id" : 114973,
    "reactomeId" : 10261454,
    "displayName" : "SHIP1,2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1170,
      "y" : 1018
    },
    "minX" : 1142,
    "maxX" : 1233,
    "minY" : 1007,
    "maxY" : 1083,
    "prop" : {
      "x" : 1142,
      "y" : 1007,
      "width" : 56,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1142,
      "y" : 1008
    },
    "connectors" : [ {
      "edgeId" : 114972,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1181,
          "y" : 1036
        },
        "to" : {
          "x" : 1233,
          "y" : 1083
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1201,
            "y" : 1053
          },
          "b" : {
            "x" : 1213,
            "y" : 1065
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1207,
            "y" : 1059
          }
        }
      }
    } ]
  }, {
    "id" : 114974,
    "reactomeId" : 10261456,
    "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP1,2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1322,
      "y" : 1891
    },
    "minX" : 1260,
    "maxX" : 1391,
    "minY" : 1846,
    "maxY" : 1930,
    "prop" : {
      "x" : 1260,
      "y" : 1852,
      "width" : 125,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1269,
      "y" : 1853
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1385,
          "y" : 1852
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1385,
          "y" : 1852
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114972,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114977,
    "reactomeId" : 10261460,
    "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 402,
      "y" : 1895
    },
    "minX" : 339,
    "maxX" : 495,
    "minY" : 1853,
    "maxY" : 1931,
    "prop" : {
      "x" : 339,
      "y" : 1859,
      "width" : 126,
      "height" : 72
    },
    "textPosition" : {
      "x" : 348,
      "y" : 1854
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 465,
          "y" : 1859
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 465,
          "y" : 1859
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114975,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 468,
          "y" : 1883
        },
        "to" : {
          "x" : 495,
          "y" : 1878
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114976,
    "reactomeId" : 10231172,
    "displayName" : "GRB2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 442,
      "y" : 1801
    },
    "minX" : 409,
    "maxX" : 565,
    "minY" : 1625,
    "maxY" : 1878,
    "prop" : {
      "x" : 409,
      "y" : 1790,
      "width" : 66,
      "height" : 22
    },
    "textPosition" : {
      "x" : 421,
      "y" : 1790
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 475,
          "y" : 1790
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 475,
          "y" : 1790
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114975,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 449,
          "y" : 1815
        },
        "to" : {
          "x" : 495,
          "y" : 1878
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 466,
            "y" : 1840
          },
          "b" : {
            "x" : 478,
            "y" : 1852
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 472,
            "y" : 1846
          }
        }
      }
    }, {
      "edgeId" : 114994,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 449,
          "y" : 1787
        },
        "to" : {
          "x" : 565,
          "y" : 1625
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114978,
    "reactomeId" : 10261462,
    "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP:GRB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 631,
      "y" : 1898
    },
    "minX" : 569,
    "maxX" : 700,
    "minY" : 1859,
    "maxY" : 1931,
    "prop" : {
      "x" : 569,
      "y" : 1865,
      "width" : 125,
      "height" : 66
    },
    "textPosition" : {
      "x" : 578,
      "y" : 1854
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 694,
          "y" : 1865
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 694,
          "y" : 1865
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114975,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114981,
    "reactomeId" : 10261319,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 80,
      "y" : 1485
    },
    "minX" : 15,
    "maxX" : 152,
    "minY" : 1430,
    "maxY" : 1587,
    "prop" : {
      "x" : 15,
      "y" : 1436,
      "width" : 131,
      "height" : 98
    },
    "textPosition" : {
      "x" : 13,
      "y" : 1443
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 146,
          "y" : 1436
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 146,
          "y" : 1436
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114979,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114982,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114982,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 54,
          "y" : 1537
        },
        "to" : {
          "x" : 29,
          "y" : 1582
        }
      }, {
        "from" : {
          "x" : 29,
          "y" : 1582
        },
        "to" : {
          "x" : 63,
          "y" : 1583
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 67,
          "y" : 1583
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 67,
          "y" : 1583
        }
      }
    } ]
  }, {
    "id" : 114980,
    "reactomeId" : 10253000,
    "displayName" : "PTPN6,PTPN11",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 398,
      "y" : 1496
    },
    "minX" : 352,
    "maxX" : 444,
    "minY" : 1443,
    "maxY" : 1511,
    "prop" : {
      "x" : 352,
      "y" : 1482,
      "width" : 92,
      "height" : 29
    },
    "textPosition" : {
      "x" : 370,
      "y" : 1479
    },
    "connectors" : [ {
      "edgeId" : 114979,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 386,
          "y" : 1476
        },
        "to" : {
          "x" : 355,
          "y" : 1443
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114983,
    "reactomeId" : 10261946,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 81,
      "y" : 1665
    },
    "minX" : 16,
    "maxX" : 153,
    "minY" : 1610,
    "maxY" : 1714,
    "prop" : {
      "x" : 16,
      "y" : 1616,
      "width" : 131,
      "height" : 98
    },
    "textPosition" : {
      "x" : 14,
      "y" : 1623
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 147,
          "y" : 1616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 147,
          "y" : 1616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114982,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114985,
    "reactomeId" : 10231376,
    "displayName" : "YWHAZ",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 263,
      "y" : 510
    },
    "minX" : 201,
    "maxX" : 307,
    "minY" : 482,
    "maxY" : 526,
    "prop" : {
      "x" : 225,
      "y" : 495,
      "width" : 76,
      "height" : 31
    },
    "textPosition" : {
      "x" : 237,
      "y" : 500
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 301,
          "y" : 495
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 301,
          "y" : 495
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114984,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 228,
          "y" : 492
        },
        "to" : {
          "x" : 201,
          "y" : 482
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114987,
    "reactomeId" : 10261438,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 95,
      "y" : 424
    },
    "minX" : 30,
    "maxX" : 206,
    "minY" : 362,
    "maxY" : 473,
    "prop" : {
      "x" : 30,
      "y" : 375,
      "width" : 131,
      "height" : 98
    },
    "textPosition" : {
      "x" : 28,
      "y" : 382
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 161,
          "y" : 375
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 161,
          "y" : 375
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114984,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114992,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 164,
          "y" : 387
        },
        "to" : {
          "x" : 206,
          "y" : 362
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114986,
    "reactomeId" : 10261436,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 95,
      "y" : 530
    },
    "minX" : 30,
    "maxX" : 201,
    "minY" : 482,
    "maxY" : 572,
    "prop" : {
      "x" : 30,
      "y" : 489,
      "width" : 131,
      "height" : 83
    },
    "textPosition" : {
      "x" : 28,
      "y" : 492
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114984,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 167,
          "y" : 500
        },
        "to" : {
          "x" : 201,
          "y" : 482
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114989,
    "reactomeId" : 10246474,
    "displayName" : "VAV1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 797,
      "y" : 1768
    },
    "minX" : 771,
    "maxX" : 830,
    "minY" : 1724,
    "maxY" : 1808,
    "prop" : {
      "x" : 777,
      "y" : 1757,
      "width" : 41,
      "height" : 23
    },
    "textPosition" : {
      "x" : 777,
      "y" : 1758
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 818,
          "y" : 1757
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 818,
          "y" : 1757
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114988,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 789,
          "y" : 1783
        },
        "to" : {
          "x" : 771,
          "y" : 1808
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114998,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 805,
          "y" : 1754
        },
        "to" : {
          "x" : 830,
          "y" : 1724
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114991,
    "reactomeId" : 10260977,
    "displayName" : "TEC:VAV1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 773,
      "y" : 1870
    },
    "minX" : 738,
    "maxX" : 815,
    "minY" : 1853,
    "maxY" : 1882,
    "prop" : {
      "x" : 738,
      "y" : 1859,
      "width" : 71,
      "height" : 23
    },
    "textPosition" : {
      "x" : 740,
      "y" : 1861
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 809,
          "y" : 1859
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 809,
          "y" : 1859
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114988,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114990,
    "reactomeId" : 10246777,
    "displayName" : "TEC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 744,
      "y" : 1768
    },
    "minX" : 727,
    "maxX" : 771,
    "minY" : 1751,
    "maxY" : 1808,
    "prop" : {
      "x" : 727,
      "y" : 1757,
      "width" : 34,
      "height" : 23
    },
    "textPosition" : {
      "x" : 728,
      "y" : 1758
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 761,
          "y" : 1757
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 761,
          "y" : 1757
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114988,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 751,
          "y" : 1783
        },
        "to" : {
          "x" : 771,
          "y" : 1808
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114993,
    "reactomeId" : 10261951,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 104,
      "y" : 301
    },
    "minX" : 30,
    "maxX" : 185,
    "minY" : 238,
    "maxY" : 358,
    "prop" : {
      "x" : 30,
      "y" : 244,
      "width" : 149,
      "height" : 114
    },
    "textPosition" : {
      "x" : 30,
      "y" : 253
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 179,
          "y" : 244
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 179,
          "y" : 244
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114992,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114995,
    "reactomeId" : 10260985,
    "displayName" : "FYN-like kinases",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 462,
      "y" : 1631
    },
    "minX" : 412,
    "maxX" : 565,
    "minY" : 1615,
    "maxY" : 1648,
    "prop" : {
      "x" : 412,
      "y" : 1615,
      "width" : 101,
      "height" : 33
    },
    "textPosition" : {
      "x" : 432,
      "y" : 1614
    },
    "connectors" : [ {
      "edgeId" : 114994,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 519,
          "y" : 1628
        },
        "to" : {
          "x" : 565,
          "y" : 1625
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114997,
    "reactomeId" : 10260987,
    "displayName" : "FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 717,
      "y" : 1287
    },
    "minX" : 657,
    "maxX" : 784,
    "minY" : 1247,
    "maxY" : 1321,
    "prop" : {
      "x" : 657,
      "y" : 1253,
      "width" : 121,
      "height" : 68
    },
    "textPosition" : {
      "x" : 660,
      "y" : 1258
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 778,
          "y" : 1253
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 778,
          "y" : 1253
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114994,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114996,
    "reactomeId" : 10240822,
    "displayName" : "CBL",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 561,
      "y" : 1714
    },
    "minX" : 538,
    "maxX" : 591,
    "minY" : 1625,
    "maxY" : 1725,
    "prop" : {
      "x" : 538,
      "y" : 1704,
      "width" : 47,
      "height" : 21
    },
    "textPosition" : {
      "x" : 546,
      "y" : 1704
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 585,
          "y" : 1704
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 585,
          "y" : 1704
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114994,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 561,
          "y" : 1701
        },
        "to" : {
          "x" : 565,
          "y" : 1625
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114999,
    "reactomeId" : 10261328,
    "displayName" : "phospho-CBL",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 676,
      "y" : 1641
    },
    "minX" : 619,
    "maxX" : 830,
    "minY" : 1533,
    "maxY" : 1724,
    "prop" : {
      "x" : 619,
      "y" : 1616,
      "width" : 114,
      "height" : 50
    },
    "textPosition" : {
      "x" : 631,
      "y" : 1630
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 733,
          "y" : 1616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 733,
          "y" : 1616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114998,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 722,
          "y" : 1669
        },
        "to" : {
          "x" : 830,
          "y" : 1724
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 115005,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 704,
          "y" : 1613
        },
        "to" : {
          "x" : 798,
          "y" : 1533
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115000,
    "reactomeId" : 10261409,
    "displayName" : "p(Y700,731,774)-CBL:VAV1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 966,
      "y" : 1725
    },
    "minX" : 903,
    "maxX" : 1035,
    "minY" : 1700,
    "maxY" : 1744,
    "prop" : {
      "x" : 903,
      "y" : 1706,
      "width" : 126,
      "height" : 38
    },
    "textPosition" : {
      "x" : 907,
      "y" : 1709
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1029,
          "y" : 1706
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1029,
          "y" : 1706
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114998,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115003,
    "reactomeId" : 10261376,
    "displayName" : "K48polyUb",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 614,
      "y" : 1073
    },
    "minX" : 554,
    "maxX" : 683,
    "minY" : 1036,
    "maxY" : 1088,
    "prop" : {
      "x" : 554,
      "y" : 1059,
      "width" : 120,
      "height" : 29
    },
    "textPosition" : {
      "x" : 577,
      "y" : 1063
    },
    "connectors" : [ {
      "edgeId" : 115001,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 641,
          "y" : 1056
        },
        "to" : {
          "x" : 683,
          "y" : 1036
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115002,
    "reactomeId" : 10261330,
    "displayName" : "FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 783,
      "y" : 1083
    },
    "minX" : 683,
    "maxX" : 852,
    "minY" : 1036,
    "maxY" : 1117,
    "prop" : {
      "x" : 720,
      "y" : 1049,
      "width" : 126,
      "height" : 68
    },
    "textPosition" : {
      "x" : 723,
      "y" : 1054
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 846,
          "y" : 1049
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 846,
          "y" : 1049
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 115001,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 717,
          "y" : 1053
        },
        "to" : {
          "x" : 683,
          "y" : 1036
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115004,
    "reactomeId" : 10261397,
    "displayName" : "FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 681,
      "y" : 906
    },
    "minX" : 621,
    "maxX" : 748,
    "minY" : 859,
    "maxY" : 948,
    "prop" : {
      "x" : 621,
      "y" : 865,
      "width" : 121,
      "height" : 83
    },
    "textPosition" : {
      "x" : 621,
      "y" : 871
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 742,
          "y" : 865
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 742,
          "y" : 865
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 115001,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115007,
    "reactomeId" : 10261413,
    "displayName" : "p(Y700,731,774)-CBL:CRK",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 995,
      "y" : 1532
    },
    "minX" : 932,
    "maxX" : 1068,
    "minY" : 1479,
    "maxY" : 1551,
    "prop" : {
      "x" : 932,
      "y" : 1513,
      "width" : 126,
      "height" : 38
    },
    "textPosition" : {
      "x" : 936,
      "y" : 1516
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1058,
          "y" : 1513
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1058,
          "y" : 1513
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 115008,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1021,
          "y" : 1510
        },
        "to" : {
          "x" : 1068,
          "y" : 1479
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 115005,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115006,
    "reactomeId" : 10252389,
    "displayName" : "CRK, CRKL",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 743,
      "y" : 1504
    },
    "minX" : 708,
    "maxX" : 798,
    "minY" : 1493,
    "maxY" : 1533,
    "prop" : {
      "x" : 708,
      "y" : 1493,
      "width" : 71,
      "height" : 22
    },
    "textPosition" : {
      "x" : 709,
      "y" : 1493
    },
    "connectors" : [ {
      "edgeId" : 115005,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 763,
          "y" : 1521
        },
        "to" : {
          "x" : 798,
          "y" : 1533
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115009,
    "reactomeId" : 10239042,
    "displayName" : "RAPGEF1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1003,
      "y" : 1458
    },
    "minX" : 971,
    "maxX" : 1068,
    "minY" : 1441,
    "maxY" : 1479,
    "prop" : {
      "x" : 971,
      "y" : 1447,
      "width" : 65,
      "height" : 22
    },
    "textPosition" : {
      "x" : 971,
      "y" : 1447
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1036,
          "y" : 1447
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1036,
          "y" : 1447
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 115008,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1039,
          "y" : 1468
        },
        "to" : {
          "x" : 1068,
          "y" : 1479
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115010,
    "reactomeId" : 10261415,
    "displayName" : "p(Y700,731,774)-CBL:CRK:RAPGEF1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1202,
      "y" : 1482
    },
    "minX" : 1139,
    "maxX" : 1271,
    "minY" : 1457,
    "maxY" : 1501,
    "prop" : {
      "x" : 1139,
      "y" : 1463,
      "width" : 126,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1143,
      "y" : 1466
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1265,
          "y" : 1463
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1265,
          "y" : 1463
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 115008,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 115017,
    "reactomeId" : 10260918,
    "displayName" : "IL3:IL3RA:IL3RB:JAK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1149,
      "y" : 88
    },
    "minX" : 1085,
    "maxX" : 1219,
    "minY" : 63,
    "maxY" : 107,
    "prop" : {
      "x" : 1085,
      "y" : 69,
      "width" : 128,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1097,
      "y" : 72
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1213,
          "y" : 69
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1213,
          "y" : 69
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 115019,
    "reactomeId" : 10238034,
    "displayName" : "PTPN11",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 394,
      "y" : 1559
    },
    "minX" : 363,
    "maxX" : 431,
    "minY" : 1542,
    "maxY" : 1571,
    "prop" : {
      "x" : 363,
      "y" : 1548,
      "width" : 62,
      "height" : 23
    },
    "textPosition" : {
      "x" : 366,
      "y" : 1549
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 425,
          "y" : 1548
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 425,
          "y" : 1548
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 115018,
    "reactomeId" : 10259094,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1592,
      "y" : 658
    },
    "minX" : 1527,
    "maxX" : 1658,
    "minY" : 602,
    "maxY" : 715,
    "prop" : {
      "x" : 1527,
      "y" : 602,
      "width" : 131,
      "height" : 113
    },
    "textPosition" : {
      "x" : 1525,
      "y" : 606
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ ]
  }, {
    "id" : 115025,
    "reactomeId" : 10331273,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1420,
      "y" : 1499
    },
    "minX" : 1359,
    "maxX" : 1481,
    "minY" : 1470,
    "maxY" : 1529,
    "prop" : {
      "x" : 1359,
      "y" : 1470,
      "width" : 122,
      "height" : 59
    },
    "textPosition" : {
      "x" : 1361,
      "y" : 1478
    },
    "connectors" : [ ]
  }, {
    "id" : 114921,
    "reactomeId" : 10259066,
    "displayName" : "CSF2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 567,
      "y" : 25
    },
    "minX" : 535,
    "maxX" : 622,
    "minY" : 8,
    "maxY" : 49,
    "prop" : {
      "x" : 535,
      "y" : 14,
      "width" : 65,
      "height" : 23
    },
    "textPosition" : {
      "x" : 548,
      "y" : 15
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 600,
          "y" : 14
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 600,
          "y" : 14
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114919,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 593,
          "y" : 40
        },
        "to" : {
          "x" : 622,
          "y" : 49
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114920,
    "reactomeId" : 10259062,
    "displayName" : "CSF2RA",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 567,
      "y" : 93
    },
    "minX" : 532,
    "maxX" : 622,
    "minY" : 49,
    "maxY" : 106,
    "prop" : {
      "x" : 532,
      "y" : 80,
      "width" : 71,
      "height" : 26
    },
    "textPosition" : {
      "x" : 540,
      "y" : 82
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 603,
          "y" : 80
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 603,
          "y" : 80
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114919,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 583,
          "y" : 77
        },
        "to" : {
          "x" : 622,
          "y" : 49
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114922,
    "reactomeId" : 10259068,
    "displayName" : "GM-CSF:GM-CSF receptor alpha subunit",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 726,
      "y" : 82
    },
    "minX" : 669,
    "maxX" : 869,
    "minY" : 50,
    "maxY" : 206,
    "prop" : {
      "x" : 669,
      "y" : 56,
      "width" : 115,
      "height" : 53
    },
    "textPosition" : {
      "x" : 672,
      "y" : 60
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 784,
          "y" : 56
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 784,
          "y" : 56
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114919,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114923,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 756,
          "y" : 112
        },
        "to" : {
          "x" : 869,
          "y" : 206
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114925,
    "reactomeId" : 10260922,
    "displayName" : "GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1310,
      "y" : 89
    },
    "minX" : 1253,
    "maxX" : 1374,
    "minY" : 49,
    "maxY" : 123,
    "prop" : {
      "x" : 1253,
      "y" : 55,
      "width" : 115,
      "height" : 68
    },
    "textPosition" : {
      "x" : 1252,
      "y" : 60
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1368,
          "y" : 55
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1368,
          "y" : 55
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114923,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114924,
    "reactomeId" : 10260916,
    "displayName" : "IL3RB:JAK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 81,
      "y" : 212
    },
    "minX" : 33,
    "maxX" : 1139,
    "minY" : 193,
    "maxY" : 245,
    "prop" : {
      "x" : 33,
      "y" : 199,
      "width" : 96,
      "height" : 26
    },
    "textPosition" : {
      "x" : 45,
      "y" : 204
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 129,
          "y" : 199
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 129,
          "y" : 199
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114923,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 132,
          "y" : 211
        },
        "to" : {
          "x" : 869,
          "y" : 206
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114935,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 132,
          "y" : 213
        },
        "to" : {
          "x" : 1139,
          "y" : 245
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114927,
    "reactomeId" : 10261003,
    "displayName" : "High affinity binding complexes of interleukin receptors using the Common beta chain",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 95,
      "y" : 659
    },
    "minX" : 30,
    "maxX" : 161,
    "minY" : 618,
    "maxY" : 729,
    "prop" : {
      "x" : 30,
      "y" : 618,
      "width" : 131,
      "height" : 83
    },
    "textPosition" : {
      "x" : 28,
      "y" : 614
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114926,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 88,
            "y" : 717
          },
          "b" : {
            "x" : 100,
            "y" : 729
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 94,
            "y" : 723
          }
        }
      }
    } ]
  }, {
    "id" : 114928,
    "reactomeId" : 10260930,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 95,
      "y" : 817
    },
    "minX" : 30,
    "maxX" : 1495,
    "minY" : 207,
    "maxY" : 906,
    "prop" : {
      "x" : 30,
      "y" : 776,
      "width" : 131,
      "height" : 83
    },
    "textPosition" : {
      "x" : 28,
      "y" : 779
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114950,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 167,
          "y" : 788
        },
        "to" : {
          "x" : 1495,
          "y" : 207
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114926,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114937,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 148,
          "y" : 865
        },
        "to" : {
          "x" : 174,
          "y" : 878
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114937,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 112,
          "y" : 865
        },
        "to" : {
          "x" : 130,
          "y" : 901
        }
      }, {
        "from" : {
          "x" : 130,
          "y" : 901
        },
        "to" : {
          "x" : 157,
          "y" : 902
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 161,
          "y" : 902
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 161,
          "y" : 902
        }
      }
    } ]
  }, {
    "id" : 114931,
    "reactomeId" : 10259084,
    "displayName" : "IL5 homodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 907,
      "y" : 18
    },
    "minX" : 857,
    "maxX" : 963,
    "minY" : 1,
    "maxY" : 54,
    "prop" : {
      "x" : 857,
      "y" : 7,
      "width" : 100,
      "height" : 22
    },
    "textPosition" : {
      "x" : 857,
      "y" : 8
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 957,
          "y" : 7
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 957,
          "y" : 7
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114929,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114932,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 917,
          "y" : 32
        },
        "to" : {
          "x" : 940,
          "y" : 54
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114930,
    "reactomeId" : 10259082,
    "displayName" : "IL5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 757,
      "y" : 18
    },
    "minX" : 744,
    "maxX" : 803,
    "minY" : 1,
    "maxY" : 30,
    "prop" : {
      "x" : 744,
      "y" : 7,
      "width" : 26,
      "height" : 23
    },
    "textPosition" : {
      "x" : 744,
      "y" : 8
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 770,
          "y" : 7
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 770,
          "y" : 7
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114929,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 791,
            "y" : 12
          },
          "b" : {
            "x" : 803,
            "y" : 24
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 797,
            "y" : 18
          }
        }
      }
    } ]
  }, {
    "id" : 114933,
    "reactomeId" : 10259078,
    "displayName" : "IL5RA",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 894,
      "y" : 92
    },
    "minX" : 872,
    "maxX" : 940,
    "minY" : 54,
    "maxY" : 104,
    "prop" : {
      "x" : 872,
      "y" : 81,
      "width" : 44,
      "height" : 23
    },
    "textPosition" : {
      "x" : 873,
      "y" : 82
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 916,
          "y" : 81
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 916,
          "y" : 81
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114932,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 907,
          "y" : 78
        },
        "to" : {
          "x" : 940,
          "y" : 54
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114934,
    "reactomeId" : 10259086,
    "displayName" : "IL5 homodimer:IL5RA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 995,
      "y" : 95
    },
    "minX" : 943,
    "maxX" : 1139,
    "minY" : 71,
    "maxY" : 245,
    "prop" : {
      "x" : 943,
      "y" : 77,
      "width" : 104,
      "height" : 36
    },
    "textPosition" : {
      "x" : 943,
      "y" : 78
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1047,
          "y" : 77
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1047,
          "y" : 77
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114932,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114935,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1012,
          "y" : 116
        },
        "to" : {
          "x" : 1139,
          "y" : 245
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114936,
    "reactomeId" : 10260926,
    "displayName" : "IL5 homodimer:IL5RA:Common beta chain:JAK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1490,
      "y" : 85
    },
    "minX" : 1437,
    "maxX" : 1549,
    "minY" : 53,
    "maxY" : 112,
    "prop" : {
      "x" : 1437,
      "y" : 59,
      "width" : 106,
      "height" : 53
    },
    "textPosition" : {
      "x" : 1437,
      "y" : 63
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1543,
          "y" : 59
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1543,
          "y" : 59
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114935,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114939,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 222,
      "y" : 955
    },
    "minX" : 174,
    "maxX" : 244,
    "minY" : 930,
    "maxY" : 971,
    "prop" : {
      "x" : 201,
      "y" : 940,
      "width" : 42,
      "height" : 31
    },
    "textPosition" : {
      "x" : 205,
      "y" : 945
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 238,
          "y" : 945
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 238,
          "y" : 945
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114937,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 198,
          "y" : 944
        },
        "to" : {
          "x" : 174,
          "y" : 930
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 180,
            "y" : 931
          },
          "b" : {
            "x" : 192,
            "y" : 943
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 186,
            "y" : 937
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 190,
          "y" : 944
        },
        "b" : {
          "x" : 198,
          "y" : 944
        },
        "c" : {
          "x" : 194,
          "y" : 937
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 194,
          "y" : 937
        }
      }
    } ]
  }, {
    "id" : 114938,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 224,
      "y" : 842
    },
    "minX" : 174,
    "maxX" : 246,
    "minY" : 826,
    "maxY" : 878,
    "prop" : {
      "x" : 203,
      "y" : 827,
      "width" : 42,
      "height" : 31
    },
    "textPosition" : {
      "x" : 208,
      "y" : 832
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 240,
          "y" : 832
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 240,
          "y" : 832
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 114937,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 200,
          "y" : 857
        },
        "to" : {
          "x" : 174,
          "y" : 878
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 181,
            "y" : 861
          },
          "b" : {
            "x" : 193,
            "y" : 873
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 187,
            "y" : 867
          }
        }
      }
    } ]
  }, {
    "id" : 114940,
    "reactomeId" : 10260972,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 95,
      "y" : 989
    },
    "minX" : 4,
    "maxX" : 174,
    "minY" : 930,
    "maxY" : 1155,
    "prop" : {
      "x" : 30,
      "y" : 948,
      "width" : 131,
      "height" : 83
    },
    "textPosition" : {
      "x" : 28,
      "y" : 951
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114948,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 57,
          "y" : 1037
        },
        "to" : {
          "x" : 6,
          "y" : 1087
        }
      }, {
        "from" : {
          "x" : 6,
          "y" : 1087
        },
        "to" : {
          "x" : 4,
          "y" : 1155
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 55,
          "y" : 1045
        },
        "b" : {
          "x" : 57,
          "y" : 1037
        },
        "c" : {
          "x" : 49,
          "y" : 1039
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 49,
          "y" : 1039
        }
      }
    }, {
      "edgeId" : 114937,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 150,
          "y" : 942
        },
        "to" : {
          "x" : 174,
          "y" : 930
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 154,
          "y" : 935
        },
        "b" : {
          "x" : 150,
          "y" : 942
        },
        "c" : {
          "x" : 158,
          "y" : 942
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 158,
          "y" : 942
        }
      }
    }, {
      "edgeId" : 114941,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 154,
          "y" : 1037
        },
        "to" : {
          "x" : 168,
          "y" : 1040
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114943,
    "reactomeId" : 10260959,
    "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 103,
      "y" : 1122
    },
    "minX" : 38,
    "maxX" : 175,
    "minY" : 1081,
    "maxY" : 1225,
    "prop" : {
      "x" : 38,
      "y" : 1081,
      "width" : 131,
      "height" : 83
    },
    "textPosition" : {
      "x" : 36,
      "y" : 1084
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 114944,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 143,
          "y" : 1170
        },
        "to" : {
          "x" : 175,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 114944,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 104,
          "y" : 1170
        },
        "to" : {
          "x" : 106,
          "y" : 1221
        }
      }, {
        "from" : {
          "x" : 106,
          "y" : 1221
        },
        "to" : {
          "x" : 159,
          "y" : 1221
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 163,
          "y" : 1221
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 163,
          "y" : 1221
        }
      }
    }, {
      "edgeId" : 114941,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 114942,
    "reactomeId" : 10259008,
    "displayName" : "STAT5A,STAT5B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 238,
      "y" : 1004
    },
    "minX" : 168,
    "maxX" : 280,
    "minY" : 987,
    "maxY" : 1040,
    "prop" : {
      "x" : 197,
      "y" : 987,
      "width" : 83,
      "height" : 34
    },
    "textPosition" : {
      "x" : 209,
      "y" : 987
    },
    "connectors" : [ {
      "edgeId" : 114941,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 204,
          "y" : 1027
        },
        "to" : {
          "x" : 168,
          "y" : 1040
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 180,
            "y" : 1027
          },
          "b" : {
            "x" : 192,
            "y" : 1039
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 186,
            "y" : 1033
          }
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 115008,
    "reactomeId" : 10261417,
    "displayName" : "CBL:CRKL binds RAPGEF1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1103,
      "y" : 1478
    },
    "minX" : 1068,
    "maxX" : 1136,
    "minY" : 1472,
    "maxY" : 1484,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1068,
        "y" : 1479
      },
      "to" : {
        "x" : 1103,
        "y" : 1478
      }
    }, {
      "from" : {
        "x" : 1103,
        "y" : 1478
      },
      "to" : {
        "x" : 1136,
        "y" : 1479
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1129,
        "y" : 1483
      },
      "b" : {
        "x" : 1136,
        "y" : 1479
      },
      "c" : {
        "x" : 1129,
        "y" : 1475
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1129,
        "y" : 1475
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1103,
        "y" : 1478
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1103,
        "y" : 1478
      }
    },
    "inputs" : [ {
      "id" : 115007,
      "points" : [ {
        "x" : 1021,
        "y" : 1510
      } ]
    }, {
      "id" : 115009,
      "points" : [ {
        "x" : 1039,
        "y" : 1468
      } ]
    } ],
    "outputs" : [ {
      "id" : 115010
    } ]
  }, {
    "id" : 114944,
    "reactomeId" : 10260970,
    "displayName" : "Activation of STAT5a/b by JAK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 175,
      "y" : 1221
    },
    "minX" : 169,
    "maxX" : 181,
    "minY" : 1195,
    "maxY" : 1248,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 175,
        "y" : 1195
      },
      "to" : {
        "x" : 175,
        "y" : 1221
      }
    }, {
      "from" : {
        "x" : 175,
        "y" : 1221
      },
      "to" : {
        "x" : 176,
        "y" : 1248
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 169,
        "y" : 1215
      },
      "b" : {
        "x" : 181,
        "y" : 1227
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 175,
        "y" : 1221
      }
    },
    "inputs" : [ {
      "id" : 114943,
      "points" : [ {
        "x" : 143,
        "y" : 1170
      } ]
    }, {
      "id" : 114945,
      "points" : [ {
        "x" : 202,
        "y" : 1177
      } ],
      "stoichiometry" : 6
    } ],
    "outputs" : [ {
      "id" : 114946,
      "points" : [ {
        "x" : 204,
        "y" : 1267
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 114947,
      "points" : [ {
        "x" : 130,
        "y" : 1296
      } ]
    } ],
    "catalysts" : [ {
      "id" : 114943,
      "points" : [ {
        "x" : 104,
        "y" : 1170
      }, {
        "x" : 106,
        "y" : 1221
      } ]
    } ]
  }, {
    "id" : 114948,
    "reactomeId" : 10262178,
    "displayName" : "p-STAT5 dissociates from the receptor complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6,
      "y" : 1235
    },
    "minX" : 0,
    "maxX" : 60,
    "minY" : 1155,
    "maxY" : 1296,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 60,
        "y" : 1296
      },
      "to" : {
        "x" : 6,
        "y" : 1235
      }
    }, {
      "from" : {
        "x" : 6,
        "y" : 1235
      },
      "to" : {
        "x" : 4,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 0,
        "y" : 1229
      },
      "b" : {
        "x" : 12,
        "y" : 1241
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6,
        "y" : 1235
      }
    },
    "inputs" : [ {
      "id" : 114947
    } ],
    "outputs" : [ {
      "id" : 114949,
      "points" : [ {
        "x" : 201,
        "y" : 1319
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 114940,
      "points" : [ {
        "x" : 57,
        "y" : 1037
      }, {
        "x" : 6,
        "y" : 1087
      } ]
    } ]
  }, {
    "id" : 114950,
    "reactomeId" : 10260947,
    "displayName" : "Tyrosine kinases phosphorylate the receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1496,
      "y" : 231
    },
    "minX" : 1490,
    "maxX" : 1502,
    "minY" : 207,
    "maxY" : 260,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1495,
        "y" : 207
      },
      "to" : {
        "x" : 1496,
        "y" : 231
      }
    }, {
      "from" : {
        "x" : 1496,
        "y" : 231
      },
      "to" : {
        "x" : 1495,
        "y" : 260
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1490,
        "y" : 225
      },
      "b" : {
        "x" : 1502,
        "y" : 237
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1496,
        "y" : 231
      }
    },
    "inputs" : [ {
      "id" : 114928,
      "points" : [ {
        "x" : 167,
        "y" : 788
      } ]
    }, {
      "id" : 114951,
      "points" : [ {
        "x" : 1464,
        "y" : 187
      } ],
      "stoichiometry" : 12
    } ],
    "outputs" : [ {
      "id" : 114952,
      "points" : [ {
        "x" : 1521,
        "y" : 271
      } ]
    }, {
      "id" : 114953,
      "points" : [ {
        "x" : 1464,
        "y" : 299
      } ],
      "stoichiometry" : 12
    } ],
    "catalysts" : [ {
      "id" : 114954,
      "points" : [ {
        "x" : 1562,
        "y" : 201
      }, {
        "x" : 1533,
        "y" : 230
      } ]
    } ]
  }, {
    "id" : 114955,
    "reactomeId" : 10261001,
    "displayName" : "Recruitment of SHC1 is mediated by Y593 of the common beta chain",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1568,
      "y" : 401
    },
    "minX" : 1562,
    "maxX" : 1578,
    "minY" : 367,
    "maxY" : 435,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1569,
        "y" : 367
      },
      "to" : {
        "x" : 1568,
        "y" : 401
      }
    }, {
      "from" : {
        "x" : 1568,
        "y" : 401
      },
      "to" : {
        "x" : 1578,
        "y" : 435
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1572,
        "y" : 429
      },
      "b" : {
        "x" : 1578,
        "y" : 435
      },
      "c" : {
        "x" : 1580,
        "y" : 427
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1580,
        "y" : 427
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1562,
        "y" : 395
      },
      "b" : {
        "x" : 1574,
        "y" : 407
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1568,
        "y" : 401
      }
    },
    "inputs" : [ {
      "id" : 114956,
      "points" : [ {
        "x" : 1536,
        "y" : 378
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 114952,
      "points" : [ {
        "x" : 1584,
        "y" : 348
      } ]
    } ],
    "outputs" : [ {
      "id" : 114957
    } ]
  }, {
    "id" : 114958,
    "reactomeId" : 10259122,
    "displayName" : "Phosphorylated SHC1 recruits GRB2:GAB2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1592,
      "y" : 839
    },
    "minX" : 1586,
    "maxX" : 1608,
    "minY" : 822,
    "maxY" : 856,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1586,
        "y" : 822
      },
      "to" : {
        "x" : 1592,
        "y" : 839
      }
    }, {
      "from" : {
        "x" : 1592,
        "y" : 839
      },
      "to" : {
        "x" : 1608,
        "y" : 856
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1600,
        "y" : 854
      },
      "b" : {
        "x" : 1608,
        "y" : 856
      },
      "c" : {
        "x" : 1606,
        "y" : 848
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1606,
        "y" : 848
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1586,
        "y" : 833
      },
      "b" : {
        "x" : 1598,
        "y" : 845
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1592,
        "y" : 839
      }
    },
    "inputs" : [ {
      "id" : 114959,
      "points" : [ {
        "x" : 1469,
        "y" : 817
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 114960,
      "points" : [ {
        "x" : 1593,
        "y" : 803
      } ]
    } ],
    "outputs" : [ {
      "id" : 114961
    } ]
  }, {
    "id" : 114962,
    "reactomeId" : 10261323,
    "displayName" : "SHC1 mediates cytokine-induced phosphorylation of GAB2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1594,
      "y" : 978
    },
    "minX" : 1588,
    "maxX" : 1600,
    "minY" : 959,
    "maxY" : 998,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1594,
        "y" : 959
      },
      "to" : {
        "x" : 1594,
        "y" : 978
      }
    }, {
      "from" : {
        "x" : 1594,
        "y" : 978
      },
      "to" : {
        "x" : 1594,
        "y" : 998
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1588,
        "y" : 972
      },
      "b" : {
        "x" : 1600,
        "y" : 984
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1594,
        "y" : 978
      }
    },
    "inputs" : [ {
      "id" : 114961,
      "points" : [ {
        "x" : 1612,
        "y" : 932
      } ]
    }, {
      "id" : 114963,
      "points" : [ {
        "x" : 1552,
        "y" : 959
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 114964,
      "points" : [ {
        "x" : 1603,
        "y" : 1014
      } ]
    }, {
      "id" : 114965,
      "points" : [ {
        "x" : 1553,
        "y" : 998
      } ],
      "stoichiometry" : 4
    } ]
  }, {
    "id" : 114966,
    "reactomeId" : 10259950,
    "displayName" : "Gab2 binds the p85 subunit of Class 1A PI3 kinases",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1590,
      "y" : 1148
    },
    "minX" : 1584,
    "maxX" : 1596,
    "minY" : 1110,
    "maxY" : 1178,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1591,
        "y" : 1110
      },
      "to" : {
        "x" : 1590,
        "y" : 1148
      }
    }, {
      "from" : {
        "x" : 1590,
        "y" : 1148
      },
      "to" : {
        "x" : 1591,
        "y" : 1178
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1587,
        "y" : 1171
      },
      "b" : {
        "x" : 1591,
        "y" : 1178
      },
      "c" : {
        "x" : 1595,
        "y" : 1171
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1595,
        "y" : 1171
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1584,
        "y" : 1142
      },
      "b" : {
        "x" : 1596,
        "y" : 1154
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1590,
        "y" : 1148
      }
    },
    "inputs" : [ {
      "id" : 114967,
      "points" : [ {
        "x" : 1113,
        "y" : 953
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 114964,
      "points" : [ {
        "x" : 1602,
        "y" : 1090
      } ]
    } ],
    "outputs" : [ {
      "id" : 114968
    } ]
  }, {
    "id" : 114969,
    "reactomeId" : 10259126,
    "displayName" : "Phosphorylated SHC recruits GRB2:SOS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1387,
      "y" : 1318
    },
    "minX" : 1381,
    "maxX" : 1528,
    "minY" : 1197,
    "maxY" : 1358,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1388,
        "y" : 1197
      },
      "to" : {
        "x" : 1387,
        "y" : 1318
      }
    }, {
      "from" : {
        "x" : 1387,
        "y" : 1318
      },
      "to" : {
        "x" : 1528,
        "y" : 1358
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1520,
        "y" : 1360
      },
      "b" : {
        "x" : 1528,
        "y" : 1358
      },
      "c" : {
        "x" : 1522,
        "y" : 1352
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1522,
        "y" : 1352
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1387,
        "y" : 1318
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1387,
        "y" : 1318
      }
    },
    "inputs" : [ {
      "id" : 114970,
      "points" : [ {
        "x" : 1338,
        "y" : 1164
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 114960,
      "points" : [ {
        "x" : 1587,
        "y" : 803
      } ]
    } ],
    "outputs" : [ {
      "id" : 114971
    } ]
  }, {
    "id" : 114972,
    "reactomeId" : 10261458,
    "displayName" : "Phosphorylated SHC1 recruits SHIP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1319,
      "y" : 1684
    },
    "minX" : 1233,
    "maxX" : 1325,
    "minY" : 1083,
    "maxY" : 1849,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1233,
        "y" : 1083
      },
      "to" : {
        "x" : 1319,
        "y" : 1684
      }
    }, {
      "from" : {
        "x" : 1319,
        "y" : 1684
      },
      "to" : {
        "x" : 1321,
        "y" : 1849
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1317,
        "y" : 1842
      },
      "b" : {
        "x" : 1321,
        "y" : 1849
      },
      "c" : {
        "x" : 1325,
        "y" : 1842
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1325,
        "y" : 1842
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1319,
        "y" : 1684
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1319,
        "y" : 1684
      }
    },
    "inputs" : [ {
      "id" : 114960,
      "points" : [ {
        "x" : 1565,
        "y" : 803
      } ]
    }, {
      "id" : 114973,
      "points" : [ {
        "x" : 1181,
        "y" : 1036
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 114974
    } ]
  }, {
    "id" : 114975,
    "reactomeId" : 10261464,
    "displayName" : "The SHC1:SHIP1 complex is stabilized by GRB2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 519,
      "y" : 1878
    },
    "minX" : 495,
    "maxX" : 566,
    "minY" : 1872,
    "maxY" : 1886,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 495,
        "y" : 1878
      },
      "to" : {
        "x" : 519,
        "y" : 1878
      }
    }, {
      "from" : {
        "x" : 519,
        "y" : 1878
      },
      "to" : {
        "x" : 566,
        "y" : 1886
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 558,
        "y" : 1889
      },
      "b" : {
        "x" : 566,
        "y" : 1886
      },
      "c" : {
        "x" : 560,
        "y" : 1881
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 560,
        "y" : 1881
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 519,
        "y" : 1878
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 519,
        "y" : 1878
      }
    },
    "inputs" : [ {
      "id" : 114976,
      "points" : [ {
        "x" : 449,
        "y" : 1815
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 114977,
      "points" : [ {
        "x" : 468,
        "y" : 1883
      } ]
    } ],
    "outputs" : [ {
      "id" : 114978
    } ]
  }, {
    "id" : 114979,
    "reactomeId" : 10261321,
    "displayName" : "SHP1 and SHP2 bind the common beta chain",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 206,
      "y" : 1445
    },
    "minX" : 149,
    "maxX" : 355,
    "minY" : 1439,
    "maxY" : 1464,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 355,
        "y" : 1443
      },
      "to" : {
        "x" : 206,
        "y" : 1445
      }
    }, {
      "from" : {
        "x" : 206,
        "y" : 1445
      },
      "to" : {
        "x" : 149,
        "y" : 1464
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 154,
        "y" : 1458
      },
      "b" : {
        "x" : 149,
        "y" : 1464
      },
      "c" : {
        "x" : 157,
        "y" : 1466
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 157,
        "y" : 1466
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 206,
        "y" : 1445
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 206,
        "y" : 1445
      }
    },
    "inputs" : [ {
      "id" : 114980,
      "points" : [ {
        "x" : 386,
        "y" : 1476
      } ]
    }, {
      "id" : 114952,
      "points" : [ {
        "x" : 1521,
        "y" : 334
      }, {
        "x" : 541,
        "y" : 712
      }, {
        "x" : 545,
        "y" : 1335
      } ]
    } ],
    "outputs" : [ {
      "id" : 114981
    } ]
  }, {
    "id" : 114919,
    "reactomeId" : 10261444,
    "displayName" : "GM-CSF receptor alpha subunit binds GM-CSF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 643,
      "y" : 48
    },
    "minX" : 622,
    "maxX" : 666,
    "minY" : 42,
    "maxY" : 58,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 622,
        "y" : 49
      },
      "to" : {
        "x" : 643,
        "y" : 48
      }
    }, {
      "from" : {
        "x" : 643,
        "y" : 48
      },
      "to" : {
        "x" : 666,
        "y" : 58
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 658,
        "y" : 59
      },
      "b" : {
        "x" : 666,
        "y" : 58
      },
      "c" : {
        "x" : 661,
        "y" : 52
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 661,
        "y" : 52
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 643,
        "y" : 48
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 643,
        "y" : 48
      }
    },
    "inputs" : [ {
      "id" : 114920,
      "points" : [ {
        "x" : 583,
        "y" : 77
      } ]
    }, {
      "id" : 114921,
      "points" : [ {
        "x" : 593,
        "y" : 40
      } ]
    } ],
    "outputs" : [ {
      "id" : 114922
    } ]
  }, {
    "id" : 114982,
    "reactomeId" : 10261949,
    "displayName" : "SHP1 and SHP2 dephosphorylate Y628 of IL3RB",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 79,
      "y" : 1583
    },
    "minX" : 73,
    "maxX" : 85,
    "minY" : 1537,
    "maxY" : 1613,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 79,
        "y" : 1537
      },
      "to" : {
        "x" : 79,
        "y" : 1583
      }
    }, {
      "from" : {
        "x" : 79,
        "y" : 1583
      },
      "to" : {
        "x" : 79,
        "y" : 1613
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 75,
        "y" : 1606
      },
      "b" : {
        "x" : 79,
        "y" : 1613
      },
      "c" : {
        "x" : 83,
        "y" : 1606
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 83,
        "y" : 1606
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 73,
        "y" : 1577
      },
      "b" : {
        "x" : 85,
        "y" : 1589
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 79,
        "y" : 1583
      }
    },
    "inputs" : [ {
      "id" : 114981
    } ],
    "outputs" : [ {
      "id" : 114983
    } ],
    "catalysts" : [ {
      "id" : 114981,
      "points" : [ {
        "x" : 54,
        "y" : 1537
      }, {
        "x" : 29,
        "y" : 1582
      } ]
    } ]
  }, {
    "id" : 114984,
    "reactomeId" : 10261440,
    "displayName" : "p-S585-IL3RB binds 14-3-3 proteins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 201,
      "y" : 441
    },
    "minX" : 164,
    "maxX" : 207,
    "minY" : 434,
    "maxY" : 482,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 201,
        "y" : 482
      },
      "to" : {
        "x" : 201,
        "y" : 441
      }
    }, {
      "from" : {
        "x" : 201,
        "y" : 441
      },
      "to" : {
        "x" : 164,
        "y" : 434
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 172,
        "y" : 431
      },
      "b" : {
        "x" : 164,
        "y" : 434
      },
      "c" : {
        "x" : 170,
        "y" : 439
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 170,
        "y" : 439
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 201,
        "y" : 441
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 201,
        "y" : 441
      }
    },
    "inputs" : [ {
      "id" : 114985,
      "points" : [ {
        "x" : 228,
        "y" : 492
      } ]
    }, {
      "id" : 114986,
      "points" : [ {
        "x" : 167,
        "y" : 500
      } ]
    } ],
    "outputs" : [ {
      "id" : 114987
    } ]
  }, {
    "id" : 114923,
    "reactomeId" : 10261448,
    "displayName" : "GM-CSF receptor alpha:GM-CSF binds Bc",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 995,
      "y" : 205
    },
    "minX" : 869,
    "maxX" : 1250,
    "minY" : 110,
    "maxY" : 211,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 869,
        "y" : 206
      },
      "to" : {
        "x" : 995,
        "y" : 205
      }
    }, {
      "from" : {
        "x" : 995,
        "y" : 205
      },
      "to" : {
        "x" : 1250,
        "y" : 110
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1245,
        "y" : 116
      },
      "b" : {
        "x" : 1250,
        "y" : 110
      },
      "c" : {
        "x" : 1242,
        "y" : 109
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1242,
        "y" : 109
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 995,
        "y" : 205
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 995,
        "y" : 205
      }
    },
    "inputs" : [ {
      "id" : 114922,
      "points" : [ {
        "x" : 756,
        "y" : 112
      } ]
    }, {
      "id" : 114924,
      "points" : [ {
        "x" : 132,
        "y" : 211
      } ]
    } ],
    "outputs" : [ {
      "id" : 114925
    } ]
  }, {
    "id" : 114988,
    "reactomeId" : 10260979,
    "displayName" : "IL3 stimulation induces Vav binding to Tec kinase",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 771,
      "y" : 1822
    },
    "minX" : 765,
    "maxX" : 777,
    "minY" : 1808,
    "maxY" : 1856,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 771,
        "y" : 1808
      },
      "to" : {
        "x" : 771,
        "y" : 1822
      }
    }, {
      "from" : {
        "x" : 771,
        "y" : 1822
      },
      "to" : {
        "x" : 772,
        "y" : 1856
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 768,
        "y" : 1849
      },
      "b" : {
        "x" : 772,
        "y" : 1856
      },
      "c" : {
        "x" : 776,
        "y" : 1849
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 776,
        "y" : 1849
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 771,
        "y" : 1822
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 771,
        "y" : 1822
      }
    },
    "inputs" : [ {
      "id" : 114989,
      "points" : [ {
        "x" : 789,
        "y" : 1783
      } ]
    }, {
      "id" : 114990,
      "points" : [ {
        "x" : 751,
        "y" : 1783
      } ]
    } ],
    "outputs" : [ {
      "id" : 114991
    } ]
  }, {
    "id" : 114926,
    "reactomeId" : 10261005,
    "displayName" : "The receptor is activated",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 94,
      "y" : 740
    },
    "minX" : 88,
    "maxX" : 100,
    "minY" : 707,
    "maxY" : 770,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 94,
        "y" : 707
      },
      "to" : {
        "x" : 94,
        "y" : 740
      }
    }, {
      "from" : {
        "x" : 94,
        "y" : 740
      },
      "to" : {
        "x" : 94,
        "y" : 770
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 90,
        "y" : 763
      },
      "b" : {
        "x" : 94,
        "y" : 770
      },
      "c" : {
        "x" : 98,
        "y" : 763
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 98,
        "y" : 763
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 88,
        "y" : 734
      },
      "b" : {
        "x" : 100,
        "y" : 746
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 94,
        "y" : 740
      }
    },
    "inputs" : [ {
      "id" : 114927,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 114928
    } ]
  }, {
    "id" : 114929,
    "reactomeId" : 10261466,
    "displayName" : "Interleukin-5 is a homodimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 821,
      "y" : 18
    },
    "minX" : 773,
    "maxX" : 854,
    "minY" : 12,
    "maxY" : 24,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 773,
        "y" : 18
      },
      "to" : {
        "x" : 821,
        "y" : 18
      }
    }, {
      "from" : {
        "x" : 821,
        "y" : 18
      },
      "to" : {
        "x" : 854,
        "y" : 18
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 847,
        "y" : 22
      },
      "b" : {
        "x" : 854,
        "y" : 18
      },
      "c" : {
        "x" : 847,
        "y" : 14
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 847,
        "y" : 14
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 821,
        "y" : 18
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 821,
        "y" : 18
      }
    },
    "inputs" : [ {
      "id" : 114930,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 114931
    } ]
  }, {
    "id" : 114992,
    "reactomeId" : 10261953,
    "displayName" : "14-3-3 zeta binding allows recruitment of PI3K",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 205,
      "y" : 313
    },
    "minX" : 182,
    "maxX" : 211,
    "minY" : 307,
    "maxY" : 362,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 206,
        "y" : 362
      },
      "to" : {
        "x" : 205,
        "y" : 313
      }
    }, {
      "from" : {
        "x" : 205,
        "y" : 313
      },
      "to" : {
        "x" : 182,
        "y" : 309
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 190,
        "y" : 306
      },
      "b" : {
        "x" : 182,
        "y" : 309
      },
      "c" : {
        "x" : 188,
        "y" : 314
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 188,
        "y" : 314
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 205,
        "y" : 313
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 205,
        "y" : 313
      }
    },
    "inputs" : [ {
      "id" : 114967,
      "points" : [ {
        "x" : 1033,
        "y" : 905
      } ]
    }, {
      "id" : 114987,
      "points" : [ {
        "x" : 164,
        "y" : 387
      } ]
    } ],
    "outputs" : [ {
      "id" : 114993
    } ]
  }, {
    "id" : 114994,
    "reactomeId" : 10260989,
    "displayName" : "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 650,
      "y" : 1445
    },
    "minX" : 565,
    "maxX" : 702,
    "minY" : 1324,
    "maxY" : 1625,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 565,
        "y" : 1625
      },
      "to" : {
        "x" : 650,
        "y" : 1445
      }
    }, {
      "from" : {
        "x" : 650,
        "y" : 1445
      },
      "to" : {
        "x" : 702,
        "y" : 1324
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 703,
        "y" : 1332
      },
      "b" : {
        "x" : 702,
        "y" : 1324
      },
      "c" : {
        "x" : 696,
        "y" : 1329
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 696,
        "y" : 1329
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 650,
        "y" : 1445
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 650,
        "y" : 1445
      }
    },
    "inputs" : [ {
      "id" : 114976,
      "points" : [ {
        "x" : 449,
        "y" : 1787
      } ]
    }, {
      "id" : 114995,
      "points" : [ {
        "x" : 519,
        "y" : 1628
      } ]
    }, {
      "id" : 114967,
      "points" : [ {
        "x" : 1048,
        "y" : 953
      } ]
    }, {
      "id" : 114996,
      "points" : [ {
        "x" : 561,
        "y" : 1701
      } ]
    } ],
    "outputs" : [ {
      "id" : 114997
    } ]
  }, {
    "id" : 114932,
    "reactomeId" : 10261468,
    "displayName" : "Interleukin-5 receptor alpha subunit binds Interleukin-5",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 975,
      "y" : 53
    },
    "minX" : 940,
    "maxX" : 986,
    "minY" : 47,
    "maxY" : 74,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 940,
        "y" : 54
      },
      "to" : {
        "x" : 975,
        "y" : 53
      }
    }, {
      "from" : {
        "x" : 975,
        "y" : 53
      },
      "to" : {
        "x" : 986,
        "y" : 74
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 979,
        "y" : 70
      },
      "b" : {
        "x" : 986,
        "y" : 74
      },
      "c" : {
        "x" : 986,
        "y" : 66
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 986,
        "y" : 66
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 975,
        "y" : 53
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 975,
        "y" : 53
      }
    },
    "inputs" : [ {
      "id" : 114931,
      "points" : [ {
        "x" : 917,
        "y" : 32
      } ]
    }, {
      "id" : 114933,
      "points" : [ {
        "x" : 907,
        "y" : 78
      } ]
    } ],
    "outputs" : [ {
      "id" : 114934
    } ]
  }, {
    "id" : 114935,
    "reactomeId" : 10261446,
    "displayName" : "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1252,
      "y" : 243
    },
    "minX" : 1139,
    "maxX" : 1450,
    "minY" : 115,
    "maxY" : 249,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1139,
        "y" : 245
      },
      "to" : {
        "x" : 1252,
        "y" : 243
      }
    }, {
      "from" : {
        "x" : 1252,
        "y" : 243
      },
      "to" : {
        "x" : 1450,
        "y" : 115
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1446,
        "y" : 122
      },
      "b" : {
        "x" : 1450,
        "y" : 115
      },
      "c" : {
        "x" : 1442,
        "y" : 115
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1442,
        "y" : 115
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1252,
        "y" : 243
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1252,
        "y" : 243
      }
    },
    "inputs" : [ {
      "id" : 114934,
      "points" : [ {
        "x" : 1012,
        "y" : 116
      } ]
    }, {
      "id" : 114924,
      "points" : [ {
        "x" : 132,
        "y" : 213
      } ]
    } ],
    "outputs" : [ {
      "id" : 114936
    } ]
  }, {
    "id" : 114998,
    "reactomeId" : 10261411,
    "displayName" : "CBL binds VAV",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 865,
      "y" : 1724
    },
    "minX" : 830,
    "maxX" : 900,
    "minY" : 1718,
    "maxY" : 1730,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 830,
        "y" : 1724
      },
      "to" : {
        "x" : 865,
        "y" : 1724
      }
    }, {
      "from" : {
        "x" : 865,
        "y" : 1724
      },
      "to" : {
        "x" : 900,
        "y" : 1724
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 893,
        "y" : 1728
      },
      "b" : {
        "x" : 900,
        "y" : 1724
      },
      "c" : {
        "x" : 893,
        "y" : 1720
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 893,
        "y" : 1720
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 865,
        "y" : 1724
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 865,
        "y" : 1724
      }
    },
    "inputs" : [ {
      "id" : 114999,
      "points" : [ {
        "x" : 722,
        "y" : 1669
      } ]
    }, {
      "id" : 114989,
      "points" : [ {
        "x" : 805,
        "y" : 1754
      } ]
    } ],
    "outputs" : [ {
      "id" : 115000
    } ]
  }, {
    "id" : 115001,
    "reactomeId" : 10261399,
    "displayName" : "CBL ubiquitinates PI3K",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 682,
      "y" : 998
    },
    "minX" : 676,
    "maxX" : 688,
    "minY" : 951,
    "maxY" : 1036,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 683,
        "y" : 1036
      },
      "to" : {
        "x" : 682,
        "y" : 998
      }
    }, {
      "from" : {
        "x" : 682,
        "y" : 998
      },
      "to" : {
        "x" : 681,
        "y" : 951
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 685,
        "y" : 958
      },
      "b" : {
        "x" : 681,
        "y" : 951
      },
      "c" : {
        "x" : 677,
        "y" : 958
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 677,
        "y" : 958
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 676,
        "y" : 992
      },
      "b" : {
        "x" : 688,
        "y" : 1004
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 682,
        "y" : 998
      }
    },
    "inputs" : [ {
      "id" : 115002,
      "points" : [ {
        "x" : 717,
        "y" : 1053
      } ]
    }, {
      "id" : 115003,
      "points" : [ {
        "x" : 641,
        "y" : 1056
      } ]
    } ],
    "outputs" : [ {
      "id" : 115004
    } ]
  }, {
    "id" : 114937,
    "reactomeId" : 10260975,
    "displayName" : "JAK2 is phosphorylated, activated",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 173,
      "y" : 902
    },
    "minX" : 167,
    "maxX" : 179,
    "minY" : 878,
    "maxY" : 930,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 174,
        "y" : 878
      },
      "to" : {
        "x" : 173,
        "y" : 902
      }
    }, {
      "from" : {
        "x" : 173,
        "y" : 902
      },
      "to" : {
        "x" : 174,
        "y" : 930
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 167,
        "y" : 896
      },
      "b" : {
        "x" : 179,
        "y" : 908
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 173,
        "y" : 902
      }
    },
    "inputs" : [ {
      "id" : 114938,
      "points" : [ {
        "x" : 200,
        "y" : 857
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 114928,
      "points" : [ {
        "x" : 148,
        "y" : 865
      } ]
    } ],
    "outputs" : [ {
      "id" : 114939,
      "points" : [ {
        "x" : 198,
        "y" : 944
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 114940,
      "points" : [ {
        "x" : 150,
        "y" : 942
      } ]
    } ],
    "catalysts" : [ {
      "id" : 114928,
      "points" : [ {
        "x" : 112,
        "y" : 865
      }, {
        "x" : 130,
        "y" : 901
      } ]
    } ]
  }, {
    "id" : 114941,
    "reactomeId" : 10260999,
    "displayName" : "STAT5 is recruited by JAK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 169,
      "y" : 1063
    },
    "minX" : 149,
    "maxX" : 175,
    "minY" : 1040,
    "maxY" : 1075,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 168,
        "y" : 1040
      },
      "to" : {
        "x" : 169,
        "y" : 1063
      }
    }, {
      "from" : {
        "x" : 169,
        "y" : 1063
      },
      "to" : {
        "x" : 149,
        "y" : 1075
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 153,
        "y" : 1068
      },
      "b" : {
        "x" : 149,
        "y" : 1075
      },
      "c" : {
        "x" : 157,
        "y" : 1075
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 157,
        "y" : 1075
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 163,
        "y" : 1057
      },
      "b" : {
        "x" : 175,
        "y" : 1069
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 169,
        "y" : 1063
      }
    },
    "inputs" : [ {
      "id" : 114940,
      "points" : [ {
        "x" : 154,
        "y" : 1037
      } ]
    }, {
      "id" : 114942,
      "points" : [ {
        "x" : 204,
        "y" : 1027
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 114943
    } ]
  }, {
    "id" : 115005,
    "reactomeId" : 10261442,
    "displayName" : "CBL binds CRK",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 861,
      "y" : 1532
    },
    "minX" : 798,
    "maxX" : 929,
    "minY" : 1526,
    "maxY" : 1538,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 798,
        "y" : 1533
      },
      "to" : {
        "x" : 861,
        "y" : 1532
      }
    }, {
      "from" : {
        "x" : 861,
        "y" : 1532
      },
      "to" : {
        "x" : 929,
        "y" : 1532
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 922,
        "y" : 1536
      },
      "b" : {
        "x" : 929,
        "y" : 1532
      },
      "c" : {
        "x" : 922,
        "y" : 1528
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 922,
        "y" : 1528
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 861,
        "y" : 1532
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 861,
        "y" : 1532
      }
    },
    "inputs" : [ {
      "id" : 115006,
      "points" : [ {
        "x" : 763,
        "y" : 1521
      } ]
    }, {
      "id" : 114999,
      "points" : [ {
        "x" : 704,
        "y" : 1613
      } ]
    } ],
    "outputs" : [ {
      "id" : 115007
    } ]
  } ],
  "compartments" : [ {
    "id" : 115011,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 830,
      "y" : 995
    },
    "minX" : 62,
    "maxX" : 1598,
    "minY" : 85,
    "maxY" : 1906,
    "prop" : {
      "x" : 62,
      "y" : 85,
      "width" : 1536,
      "height" : 1821
    },
    "textPosition" : {
      "x" : 1474,
      "y" : 1848
    },
    "insets" : {
      "x" : 72,
      "y" : 95,
      "width" : 1516,
      "height" : 1801
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 114924, 114920, 114922, 114923, 114925, 114926, 114927, 114928, 114934, 114933, 114935, 114936, 115017, 114937, 114939, 114940, 114941, 114942, 114943, 114944, 114945, 114946, 114947, 114949, 114953, 114956, 114967, 114969, 114970, 114972, 114973, 114979, 114980, 114981, 114982, 114983, 115019, 114986, 114984, 114985, 114987, 114989, 114990, 114991, 114988, 114992, 114993, 114975, 114976, 114978, 114974, 114950, 114952, 114954, 114957, 115018, 114960, 114961, 114964, 114968, 114971, 114951, 114977, 114959, 114963, 114965, 115020, 114938, 114955, 114958, 114962, 114966, 114995, 114996, 114997, 114994, 115002, 114998, 114999, 115000, 115001, 115003, 115004, 115005, 115007, 115008, 115009, 115010, 115026, 115027, 115029, 115030, 115031, 115032, 115025, 115035, 115006, 115033, 115034 ]
  }, {
    "id" : 115020,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 391,
      "y" : 1139
    },
    "minX" : 248,
    "maxX" : 535,
    "minY" : 1029,
    "maxY" : 1250,
    "prop" : {
      "x" : 248,
      "y" : 1029,
      "width" : 287,
      "height" : 221
    },
    "textPosition" : {
      "x" : 254,
      "y" : 1207
    },
    "insets" : {
      "x" : 258,
      "y" : 1039,
      "width" : 267,
      "height" : 201
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 115027,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1596,
      "y" : 724
    },
    "minX" : 1590,
    "maxX" : 1602,
    "minY" : 718,
    "maxY" : 730,
    "segments" : [ {
      "from" : {
        "x" : 1596,
        "y" : 721
      },
      "to" : {
        "x" : 1597,
        "y" : 727
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1590,
        "y" : 718
      },
      "b" : {
        "x" : 1602,
        "y" : 730
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1596,
        "y" : 724
      }
    },
    "inputs" : [ {
      "id" : 115018
    } ],
    "outputs" : [ {
      "id" : 114960
    } ]
  }, {
    "id" : 115026,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 395,
      "y" : 1531
    },
    "minX" : 389,
    "maxX" : 401,
    "minY" : 1517,
    "maxY" : 1545,
    "segments" : [ {
      "from" : {
        "x" : 394,
        "y" : 1545
      },
      "to" : {
        "x" : 396,
        "y" : 1517
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 389,
        "y" : 1525
      },
      "b" : {
        "x" : 401,
        "y" : 1537
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 395,
        "y" : 1531
      }
    },
    "inputs" : [ {
      "id" : 115019
    } ],
    "outputs" : [ {
      "id" : 114980
    } ]
  }, {
    "id" : 115029,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1539,
      "y" : 120
    },
    "minX" : 1529,
    "maxX" : 1549,
    "minY" : 114,
    "maxY" : 126,
    "segments" : [ {
      "from" : {
        "x" : 1529,
        "y" : 115
      },
      "to" : {
        "x" : 1549,
        "y" : 125
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1533,
        "y" : 114
      },
      "b" : {
        "x" : 1545,
        "y" : 126
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1539,
        "y" : 120
      }
    },
    "inputs" : [ {
      "id" : 114936
    } ],
    "outputs" : [ {
      "id" : 114954
    } ]
  }, {
    "id" : 115028,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1553,
      "y" : 17
    },
    "minX" : 1371,
    "maxX" : 1581,
    "minY" : 11,
    "maxY" : 125,
    "segments" : [ {
      "from" : {
        "x" : 1371,
        "y" : 71
      },
      "to" : {
        "x" : 1553,
        "y" : 17
      }
    }, {
      "from" : {
        "x" : 1553,
        "y" : 17
      },
      "to" : {
        "x" : 1581,
        "y" : 125
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1547,
        "y" : 11
      },
      "b" : {
        "x" : 1559,
        "y" : 23
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1553,
        "y" : 17
      }
    },
    "inputs" : [ {
      "id" : 114925
    } ],
    "outputs" : [ {
      "id" : 114954
    } ]
  }, {
    "id" : 115031,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 708,
      "y" : 372
    },
    "minX" : 167,
    "maxX" : 1250,
    "minY" : 116,
    "maxY" : 628,
    "segments" : [ {
      "from" : {
        "x" : 1250,
        "y" : 116
      },
      "to" : {
        "x" : 167,
        "y" : 628
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 702,
        "y" : 366
      },
      "b" : {
        "x" : 714,
        "y" : 378
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 708,
        "y" : 372
      }
    },
    "inputs" : [ {
      "id" : 114925
    } ],
    "outputs" : [ {
      "id" : 114927
    } ]
  }, {
    "id" : 115030,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 640,
      "y" : 366
    },
    "minX" : 167,
    "maxX" : 1114,
    "minY" : 110,
    "maxY" : 623,
    "segments" : [ {
      "from" : {
        "x" : 1114,
        "y" : 110
      },
      "to" : {
        "x" : 167,
        "y" : 623
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 634,
        "y" : 360
      },
      "b" : {
        "x" : 646,
        "y" : 372
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 640,
        "y" : 366
      }
    },
    "inputs" : [ {
      "id" : 115017
    } ],
    "outputs" : [ {
      "id" : 114927
    } ]
  }, {
    "id" : 115033,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 849,
      "y" : 577
    },
    "minX" : 167,
    "maxX" : 1531,
    "minY" : 201,
    "maxY" : 953,
    "segments" : [ {
      "from" : {
        "x" : 1531,
        "y" : 201
      },
      "to" : {
        "x" : 167,
        "y" : 953
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 843,
        "y" : 571
      },
      "b" : {
        "x" : 855,
        "y" : 583
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 849,
        "y" : 577
      }
    },
    "inputs" : [ {
      "id" : 114954
    } ],
    "outputs" : [ {
      "id" : 114940
    } ]
  }, {
    "id" : 115032,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 800,
      "y" : 368
    },
    "minX" : 167,
    "maxX" : 1434,
    "minY" : 106,
    "maxY" : 631,
    "segments" : [ {
      "from" : {
        "x" : 1434,
        "y" : 106
      },
      "to" : {
        "x" : 167,
        "y" : 631
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 794,
        "y" : 362
      },
      "b" : {
        "x" : 806,
        "y" : 374
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 800,
        "y" : 368
      }
    },
    "inputs" : [ {
      "id" : 114936
    } ],
    "outputs" : [ {
      "id" : 114927
    } ]
  }, {
    "id" : 115035,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1501,
      "y" : 1440
    },
    "minX" : 1461,
    "maxX" : 1541,
    "minY" : 1414,
    "maxY" : 1467,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1541,
        "y" : 1414
      },
      "to" : {
        "x" : 1461,
        "y" : 1467
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1465,
        "y" : 1460
      },
      "b" : {
        "x" : 1461,
        "y" : 1467
      },
      "c" : {
        "x" : 1469,
        "y" : 1467
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1469,
        "y" : 1467
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1495,
        "y" : 1434
      },
      "b" : {
        "x" : 1507,
        "y" : 1446
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1501,
        "y" : 1440
      }
    },
    "inputs" : [ {
      "id" : 114971
    } ],
    "outputs" : [ {
      "id" : 115025
    } ]
  }, {
    "id" : 115034,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 842,
      "y" : 411
    },
    "minX" : 167,
    "maxX" : 1517,
    "minY" : 185,
    "maxY" : 637,
    "segments" : [ {
      "from" : {
        "x" : 1517,
        "y" : 185
      },
      "to" : {
        "x" : 167,
        "y" : 637
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 836,
        "y" : 405
      },
      "b" : {
        "x" : 848,
        "y" : 417
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 842,
        "y" : 411
      }
    },
    "inputs" : [ {
      "id" : 114954
    } ],
    "outputs" : [ {
      "id" : 114927
    } ]
  }, {
    "id" : 115036,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1399,
      "y" : 6
    },
    "minX" : 1164,
    "maxX" : 1588,
    "minY" : 0,
    "maxY" : 125,
    "segments" : [ {
      "from" : {
        "x" : 1164,
        "y" : 66
      },
      "to" : {
        "x" : 1214,
        "y" : 7
      }
    }, {
      "from" : {
        "x" : 1214,
        "y" : 7
      },
      "to" : {
        "x" : 1585,
        "y" : 5
      }
    }, {
      "from" : {
        "x" : 1585,
        "y" : 5
      },
      "to" : {
        "x" : 1588,
        "y" : 125
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1393,
        "y" : 0
      },
      "b" : {
        "x" : 1405,
        "y" : 12
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1399,
        "y" : 6
      }
    },
    "inputs" : [ {
      "id" : 115017
    } ],
    "outputs" : [ {
      "id" : 114954
    } ]
  } ],
  "shadows" : [ {
    "id" : 115037,
    "reactomeId" : 10330473,
    "displayName" : "Interleukin receptor SHC signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1023,
      "y" : 1332
    },
    "minX" : 329,
    "maxX" : 1718,
    "minY" : 723,
    "maxY" : 1941,
    "prop" : {
      "x" : 1275,
      "y" : 855,
      "width" : 443,
      "height" : 967
    },
    "points" : [ {
      "x" : 329,
      "y" : 723
    }, {
      "x" : 1718,
      "y" : 723
    }, {
      "x" : 1718,
      "y" : 1941
    }, {
      "x" : 329,
      "y" : 1941
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 115038,
    "reactomeId" : 10330529,
    "displayName" : "Regulation of signaling by CBL",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 837,
      "y" : 1338
    },
    "minX" : 399,
    "maxX" : 1275,
    "minY" : 855,
    "maxY" : 1822,
    "prop" : {
      "x" : 399,
      "y" : 855,
      "width" : 876,
      "height" : 967
    },
    "points" : [ {
      "x" : 399,
      "y" : 855
    }, {
      "x" : 1275,
      "y" : 855
    }, {
      "x" : 1275,
      "y" : 1822
    }, {
      "x" : 399,
      "y" : 1822
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 1708,
  "minY" : 0,
  "maxY" : 1931,
  "disease" : false
}