{
  "dbId" : 10330435,
  "stId" : "R-CFA-448706",
  "speciesName" : "Canis familiaris",
  "nodes" : [ {
    "dbId" : 10258204,
    "stId" : "R-CFA-449062",
    "displayName" : "IL18 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RRK2",
    "standardIdentifier" : "uniprot:A0A8I3RRK2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18" ],
    "parents" : [ 10258208 ],
    "children" : [ ]
  }, {
    "dbId" : 10258206,
    "stId" : "R-CFA-449059",
    "displayName" : "IL1A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NHA9",
    "standardIdentifier" : "uniprot:A0A8I3NHA9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1A" ],
    "parents" : [ 10258208 ],
    "children" : [ ]
  }, {
    "dbId" : 10258200,
    "stId" : "R-CFA-449063",
    "displayName" : "Interleukin-1 family [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 76316 ],
    "parents" : [ ],
    "children" : [ 10258194, 10258196, 10258198 ]
  }, {
    "dbId" : 10258202,
    "stId" : "R-CFA-449030",
    "displayName" : "IL1B [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NVB6",
    "standardIdentifier" : "uniprot:A0A8I3NVB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B" ],
    "parents" : [ 10258208 ],
    "children" : [ ]
  }, {
    "dbId" : 10258196,
    "stId" : "R-CFA-449023",
    "displayName" : "IL18 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RRK2",
    "standardIdentifier" : "uniprot:A0A8I3RRK2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18" ],
    "parents" : [ 10258200 ],
    "children" : [ ]
  }, {
    "dbId" : 10258198,
    "stId" : "R-CFA-449054",
    "displayName" : "IL1A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NHA9",
    "standardIdentifier" : "uniprot:A0A8I3NHA9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1A" ],
    "parents" : [ 10258200 ],
    "children" : [ ]
  }, {
    "dbId" : 10258192,
    "stId" : "R-CFA-449039",
    "displayName" : "Interleukin-1 family propeptides [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 76314 ],
    "parents" : [ ],
    "children" : [ 10258184, 10258188, 10258190 ]
  }, {
    "dbId" : 10258321,
    "stId" : "R-CFA-9647676",
    "displayName" : "GSDMD oligomer:PIPs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10258323 ],
    "children" : [ 5620974, 10234701 ]
  }, {
    "dbId" : 10329107,
    "stId" : "R-CFA-5620971",
    "displayName" : "Pyroptosis",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 76323 ]
  }, {
    "dbId" : 10258194,
    "stId" : "R-CFA-449046",
    "displayName" : "IL1B [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NVB6",
    "standardIdentifier" : "uniprot:A0A8I3NVB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B" ],
    "parents" : [ 10258200 ],
    "children" : [ ]
  }, {
    "dbId" : 10258323,
    "stId" : "R-CFA-9647630",
    "displayName" : "GSDMD pore complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 76320 ],
    "parents" : [ ],
    "children" : [ 10258321 ]
  }, {
    "dbId" : 10258188,
    "stId" : "R-CFA-449033",
    "displayName" : "IL18 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RRK2",
    "standardIdentifier" : "uniprot:A0A8I3RRK2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18" ],
    "parents" : [ 10258192 ],
    "children" : [ ]
  }, {
    "dbId" : 10258317,
    "stId" : "R-CFA-448446",
    "displayName" : "IL18 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RRK2",
    "standardIdentifier" : "uniprot:A0A8I3RRK2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18" ],
    "parents" : [ 10258319 ],
    "children" : [ ]
  }, {
    "dbId" : 10234701,
    "stId" : "R-CFA-9647641",
    "displayName" : "GSDMD [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NWY6",
    "standardIdentifier" : "uniprot:A0A8I3NWY6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GSDMD" ],
    "parents" : [ 10258321 ],
    "children" : [ ]
  }, {
    "dbId" : 179856,
    "stId" : "R-ALL-179856",
    "displayName" : "PI(4,5)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "58456",
    "standardIdentifier" : "chebi:58456",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5620974 ],
    "children" : [ ]
  }, {
    "dbId" : 10258190,
    "stId" : "R-CFA-449042",
    "displayName" : "IL1A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NHA9",
    "standardIdentifier" : "uniprot:A0A8I3NHA9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1A" ],
    "parents" : [ 10258192 ],
    "children" : [ ]
  }, {
    "dbId" : 10258319,
    "stId" : "R-CFA-449027",
    "displayName" : "Interleukin-1 family [extracellular region]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 76319 ],
    "parents" : [ ],
    "children" : [ 10257610, 10258317, 10257606 ]
  }, {
    "dbId" : 10258184,
    "stId" : "R-CFA-448689",
    "displayName" : "IL1B [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NVB6",
    "standardIdentifier" : "uniprot:A0A8I3NVB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B" ],
    "parents" : [ 10258192 ],
    "children" : [ ]
  }, {
    "dbId" : 10257610,
    "stId" : "R-CFA-445748",
    "displayName" : "IL1B [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NVB6",
    "standardIdentifier" : "uniprot:A0A8I3NVB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B" ],
    "parents" : [ 10258319 ],
    "children" : [ ]
  }, {
    "dbId" : 10258180,
    "stId" : "R-CFA-448691",
    "displayName" : "Caspase-1 tetramer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 76312 ],
    "parents" : [ ],
    "children" : [ 10258163 ]
  }, {
    "dbId" : 10238341,
    "stId" : "R-CFA-177676",
    "displayName" : "RELA [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P3H3",
    "standardIdentifier" : "uniprot:A0A8I3P3H3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RELA" ],
    "parents" : [ 10238343 ],
    "children" : [ ]
  }, {
    "dbId" : 10257606,
    "stId" : "R-CFA-445746",
    "displayName" : "IL1A [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NHA9",
    "standardIdentifier" : "uniprot:A0A8I3NHA9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1A" ],
    "parents" : [ 10258319 ],
    "children" : [ ]
  }, {
    "dbId" : 10238343,
    "stId" : "R-CFA-177673",
    "displayName" : "NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 76317 ],
    "parents" : [ ],
    "children" : [ 10238339, 10238341 ]
  }, {
    "dbId" : 10238339,
    "stId" : "R-CFA-177674",
    "displayName" : "NFKB2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PK60",
    "standardIdentifier" : "uniprot:A0A8I3PK60",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NFKB2" ],
    "parents" : [ 10238343 ],
    "children" : [ ]
  }, {
    "dbId" : 10258175,
    "stId" : "R-CFA-9635429",
    "displayName" : "CTSG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 76308 ],
    "identifier" : "A0A8I3NK04",
    "standardIdentifier" : "uniprot:A0A8I3NK04",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CTSG" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 392417,
    "stId" : "R-ALL-392417",
    "displayName" : "PI4P [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "17526",
    "standardIdentifier" : "chebi:17526",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5620974 ],
    "children" : [ ]
  }, {
    "dbId" : 10258169,
    "stId" : "R-CFA-448680",
    "displayName" : "CASP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 76304 ],
    "identifier" : "A0A8I3MG12",
    "standardIdentifier" : "uniprot:A0A8I3MG12",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258171,
    "stId" : "R-CFA-448674",
    "displayName" : "CASP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 76307 ],
    "identifier" : "A0A8I3MG12",
    "standardIdentifier" : "uniprot:A0A8I3MG12",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258167,
    "stId" : "R-CFA-448692",
    "displayName" : "CASP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 76303 ],
    "identifier" : "A0A8I3MG12",
    "standardIdentifier" : "uniprot:A0A8I3MG12",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258161,
    "stId" : "R-CFA-448686",
    "displayName" : "CASP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 76306 ],
    "identifier" : "A0A8I3MG12",
    "standardIdentifier" : "uniprot:A0A8I3MG12",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4" ],
    "parents" : [ 10258163 ],
    "children" : [ ]
  }, {
    "dbId" : 10258163,
    "stId" : "R-CFA-448695",
    "displayName" : "CASP1(120-197):CASP1(317-404) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 76310 ],
    "parents" : [ 10258180 ],
    "children" : [ 10258161, 10258159 ]
  }, {
    "dbId" : 10258159,
    "stId" : "R-CFA-448704",
    "displayName" : "CASP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 76305 ],
    "identifier" : "A0A8I3MG12",
    "standardIdentifier" : "uniprot:A0A8I3MG12",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4" ],
    "parents" : [ 10258163 ],
    "children" : [ ]
  }, {
    "dbId" : 5620974,
    "stId" : "R-ALL-5620974",
    "displayName" : "PI4P,PI(4,5)P2,PIP3 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "parents" : [ 10258321 ],
    "children" : [ 179856, 392417, 179838 ]
  }, {
    "dbId" : 179838,
    "stId" : "R-ALL-179838",
    "displayName" : "PI(3,4,5)P3 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "57836",
    "standardIdentifier" : "chebi:57836",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5620974 ],
    "children" : [ ]
  }, {
    "dbId" : 10258208,
    "stId" : "R-CFA-449026",
    "displayName" : "Interleukin-1 family N-terminal propeptides [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 76315 ],
    "parents" : [ ],
    "children" : [ 10258202, 10258204, 10258206 ]
  } ],
  "edges" : [ {
    "dbId" : 10258165,
    "stId" : "R-CFA-448673",
    "displayName" : "Formation of caspase-1 p10/p20 dimer",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10258178 ],
    "following" : [ 10258182 ],
    "inputs" : [ 10258161, 10258159 ],
    "outputs" : [ 10258163 ],
    "efs" : [ ],
    "diagramIds" : [ 76309 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258325,
    "stId" : "R-CFA-449058",
    "displayName" : "Interleukin-1 family are secreted",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10258211 ],
    "inputs" : [ 10258200 ],
    "outputs" : [ 10258319 ],
    "efs" : [ ],
    "activators" : [ 10258323 ],
    "diagramIds" : [ 76318 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258182,
    "stId" : "R-CFA-448702",
    "displayName" : "Caspase-1 active tetramer formation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10258165 ],
    "following" : [ 10258211 ],
    "inputs" : [ 10258163 ],
    "outputs" : [ 10258180 ],
    "efs" : [ ],
    "diagramIds" : [ 76311 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258178,
    "stId" : "R-CFA-448678",
    "displayName" : "CTSG cleaves CASP1(1-404)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10258165 ],
    "inputs" : [ 10258167 ],
    "outputs" : [ 10258161, 10258171, 10258169, 10258159 ],
    "catalysts" : [ 10258175 ],
    "efs" : [ ],
    "diagramIds" : [ 76302 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258211,
    "stId" : "R-CFA-448703",
    "displayName" : "Interleukin-1 family precursors are cleaved by caspase-1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10258182 ],
    "following" : [ 10258325 ],
    "inputs" : [ 10258192 ],
    "outputs" : [ 10258208, 10258200 ],
    "catalysts" : [ 10258180 ],
    "efs" : [ ],
    "activators" : [ 10238343 ],
    "diagramIds" : [ 76313 ],
    "entityFunctionalStatus" : [ ]
  } ]
}