{
  "dbId" : 10330433,
  "stableId" : "R-CFA-6783589",
  "displayName" : "Interleukin-6 family signaling",
  "nodes" : [ {
    "id" : 21376,
    "reactomeId" : 10297447,
    "displayName" : "CRLF1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2339,
      "y" : 248
    },
    "minX" : 2317,
    "maxX" : 2386,
    "minY" : 217,
    "maxY" : 259,
    "prop" : {
      "x" : 2317,
      "y" : 237,
      "width" : 45,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2317,
      "y" : 237
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2362,
          "y" : 237
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2362,
          "y" : 237
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21375,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2355,
          "y" : 234
        },
        "to" : {
          "x" : 2386,
          "y" : 217
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21377,
    "reactomeId" : 10297443,
    "displayName" : "CLCF1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2336,
      "y" : 201
    },
    "minX" : 2313,
    "maxX" : 2386,
    "minY" : 184,
    "maxY" : 217,
    "prop" : {
      "x" : 2313,
      "y" : 190,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2313,
      "y" : 190
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2359,
          "y" : 190
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2359,
          "y" : 190
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21375,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2362,
          "y" : 208
        },
        "to" : {
          "x" : 2386,
          "y" : 217
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21378,
    "reactomeId" : 10297449,
    "displayName" : "CRLF1:CLCF1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2423,
      "y" : 247
    },
    "minX" : 2380,
    "maxX" : 2472,
    "minY" : 230,
    "maxY" : 330,
    "prop" : {
      "x" : 2380,
      "y" : 236,
      "width" : 86,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2380,
      "y" : 237
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2466,
          "y" : 236
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2466,
          "y" : 236
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21379,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2418,
          "y" : 261
        },
        "to" : {
          "x" : 2392,
          "y" : 330
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21375,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21380,
    "reactomeId" : 10297453,
    "displayName" : "CNTFR",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2159,
      "y" : 252
    },
    "minX" : 2136,
    "maxX" : 2392,
    "minY" : 235,
    "maxY" : 330,
    "prop" : {
      "x" : 2136,
      "y" : 241,
      "width" : 47,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2136,
      "y" : 241
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2183,
          "y" : 241
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2183,
          "y" : 241
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21379,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2186,
          "y" : 259
        },
        "to" : {
          "x" : 2392,
          "y" : 330
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21381,
    "reactomeId" : 10297455,
    "displayName" : "CNTFR:CRLF1:CLCF1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2541,
      "y" : 248
    },
    "minX" : 2477,
    "maxX" : 2612,
    "minY" : 231,
    "maxY" : 259,
    "prop" : {
      "x" : 2477,
      "y" : 237,
      "width" : 129,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2477,
      "y" : 238
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2606,
          "y" : 237
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2606,
          "y" : 237
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21379,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21383,
    "reactomeId" : 10297455,
    "displayName" : "CNTFR:CRLF1:CLCF1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 173,
      "y" : 675
    },
    "minX" : 110,
    "maxX" : 280,
    "minY" : 651,
    "maxY" : 693,
    "prop" : {
      "x" : 110,
      "y" : 657,
      "width" : 126,
      "height" : 36
    },
    "textPosition" : {
      "x" : 127,
      "y" : 657
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 236,
          "y" : 657
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 236,
          "y" : 657
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21382,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 242,
          "y" : 673
        },
        "to" : {
          "x" : 280,
          "y" : 673
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21384,
    "reactomeId" : 10298458,
    "displayName" : "CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 195,
      "y" : 491
    },
    "minX" : 132,
    "maxX" : 296,
    "minY" : 460,
    "maxY" : 516,
    "prop" : {
      "x" : 132,
      "y" : 466,
      "width" : 127,
      "height" : 50
    },
    "textPosition" : {
      "x" : 132,
      "y" : 453
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 259,
          "y" : 466
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 259,
          "y" : 466
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21382,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21389,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 262,
          "y" : 485
        },
        "to" : {
          "x" : 296,
          "y" : 483
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21386,
    "reactomeId" : 10258059,
    "displayName" : "JAK1, JAK2, (TYK2)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 388,
      "y" : 388
    },
    "minX" : 221,
    "maxX" : 431,
    "minY" : 340,
    "maxY" : 1054,
    "prop" : {
      "x" : 345,
      "y" : 369,
      "width" : 86,
      "height" : 39
    },
    "textPosition" : {
      "x" : 350,
      "y" : 371
    },
    "connectors" : [ {
      "edgeId" : 21385,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 339,
          "y" : 375
        },
        "to" : {
          "x" : 221,
          "y" : 340
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21402,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 388,
          "y" : 414
        },
        "to" : {
          "x" : 389,
          "y" : 1054
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21387,
    "reactomeId" : 10297433,
    "displayName" : "LIFR",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 169,
      "y" : 319
    },
    "minX" : 153,
    "maxX" : 221,
    "minY" : 302,
    "maxY" : 340,
    "prop" : {
      "x" : 153,
      "y" : 308,
      "width" : 32,
      "height" : 22
    },
    "textPosition" : {
      "x" : 153,
      "y" : 308
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 185,
          "y" : 308
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 185,
          "y" : 308
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21385,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 188,
          "y" : 325
        },
        "to" : {
          "x" : 221,
          "y" : 340
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21388,
    "reactomeId" : 10297435,
    "displayName" : "JAKs:LIFR",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 166,
      "y" : 382
    },
    "minX" : 101,
    "maxX" : 311,
    "minY" : 365,
    "maxY" : 727,
    "prop" : {
      "x" : 134,
      "y" : 371,
      "width" : 64,
      "height" : 22
    },
    "textPosition" : {
      "x" : 135,
      "y" : 372
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 198,
          "y" : 371
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 198,
          "y" : 371
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21385,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21389,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 180,
          "y" : 396
        },
        "to" : {
          "x" : 296,
          "y" : 483
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21391,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 131,
          "y" : 385
        },
        "to" : {
          "x" : 101,
          "y" : 390
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21405,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 187,
          "y" : 396
        },
        "to" : {
          "x" : 311,
          "y" : 455
        }
      }, {
        "from" : {
          "x" : 311,
          "y" : 455
        },
        "to" : {
          "x" : 311,
          "y" : 727
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21390,
    "reactomeId" : 10298464,
    "displayName" : "CNTF:CNTFR,CRLF1:CLCF1:CNTFR:gp130:JAKs:LIFR:JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 178,
      "y" : 608
    },
    "minX" : 115,
    "maxX" : 247,
    "minY" : 570,
    "maxY" : 640,
    "prop" : {
      "x" : 115,
      "y" : 576,
      "width" : 126,
      "height" : 64
    },
    "textPosition" : {
      "x" : 116,
      "y" : 577
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 241,
          "y" : 576
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 241,
          "y" : 576
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21389,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21392,
    "reactomeId" : 10298438,
    "displayName" : "LIF",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 65,
      "y" : 371
    },
    "minX" : 53,
    "maxX" : 101,
    "minY" : 354,
    "maxY" : 390,
    "prop" : {
      "x" : 53,
      "y" : 360,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 53,
      "y" : 360
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 78,
          "y" : 360
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 78,
          "y" : 360
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21391,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 81,
          "y" : 377
        },
        "to" : {
          "x" : 101,
          "y" : 390
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21393,
    "reactomeId" : 10298440,
    "displayName" : "LIF:LIFR:JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 174,
      "y" : 444
    },
    "minX" : 132,
    "maxX" : 222,
    "minY" : 427,
    "maxY" : 455,
    "prop" : {
      "x" : 132,
      "y" : 433,
      "width" : 84,
      "height" : 22
    },
    "textPosition" : {
      "x" : 133,
      "y" : 434
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 216,
          "y" : 433
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 216,
          "y" : 433
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21391,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21395,
    "reactomeId" : 10258061,
    "displayName" : "IL6ST",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 167,
      "y" : 273
    },
    "minX" : 6,
    "maxX" : 200,
    "minY" : 256,
    "maxY" : 883,
    "prop" : {
      "x" : 140,
      "y" : 262,
      "width" : 54,
      "height" : 23
    },
    "textPosition" : {
      "x" : 147,
      "y" : 263
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 194,
          "y" : 262
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 194,
          "y" : 262
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21394,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 141,
          "y" : 288
        },
        "to" : {
          "x" : 6,
          "y" : 347
        }
      }, {
        "from" : {
          "x" : 6,
          "y" : 347
        },
        "to" : {
          "x" : 6,
          "y" : 883
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21396,
    "reactomeId" : 10298452,
    "displayName" : "LIF,OSM,CTF1 receptor complex",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 172,
      "y" : 825
    },
    "minX" : 6,
    "maxX" : 230,
    "minY" : 807,
    "maxY" : 883,
    "prop" : {
      "x" : 115,
      "y" : 807,
      "width" : 115,
      "height" : 36
    },
    "textPosition" : {
      "x" : 126,
      "y" : 801
    },
    "connectors" : [ {
      "edgeId" : 21394,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 120,
          "y" : 849
        },
        "to" : {
          "x" : 6,
          "y" : 883
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21397,
    "reactomeId" : 10298454,
    "displayName" : "LIF,OSM receptor complex:gp130",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 168,
      "y" : 1091
    },
    "minX" : 111,
    "maxX" : 232,
    "minY" : 1067,
    "maxY" : 1109,
    "prop" : {
      "x" : 111,
      "y" : 1073,
      "width" : 115,
      "height" : 36
    },
    "textPosition" : {
      "x" : 110,
      "y" : 1074
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 226,
          "y" : 1073
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 226,
          "y" : 1073
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21394,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21399,
    "reactomeId" : 10298448,
    "displayName" : "LIFR:JAKs,OSMR:JAKs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 181,
      "y" : 929
    },
    "minX" : 103,
    "maxX" : 234,
    "minY" : 911,
    "maxY" : 970,
    "prop" : {
      "x" : 128,
      "y" : 911,
      "width" : 106,
      "height" : 36
    },
    "textPosition" : {
      "x" : 129,
      "y" : 911
    },
    "connectors" : [ {
      "edgeId" : 21398,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 146,
          "y" : 953
        },
        "to" : {
          "x" : 103,
          "y" : 970
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21400,
    "reactomeId" : 10298444,
    "displayName" : "OSM",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 85,
      "y" : 925
    },
    "minX" : 67,
    "maxX" : 109,
    "minY" : 908,
    "maxY" : 970,
    "prop" : {
      "x" : 67,
      "y" : 914,
      "width" : 36,
      "height" : 22
    },
    "textPosition" : {
      "x" : 67,
      "y" : 914
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 103,
          "y" : 914
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 103,
          "y" : 914
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21398,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 89,
          "y" : 939
        },
        "to" : {
          "x" : 103,
          "y" : 970
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21401,
    "reactomeId" : 10298450,
    "displayName" : "OSM:OSMR,LIFR",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 173,
      "y" : 1008
    },
    "minX" : 122,
    "maxX" : 230,
    "minY" : 991,
    "maxY" : 1019,
    "prop" : {
      "x" : 122,
      "y" : 997,
      "width" : 102,
      "height" : 22
    },
    "textPosition" : {
      "x" : 122,
      "y" : 998
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 224,
          "y" : 997
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 224,
          "y" : 997
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21398,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21403,
    "reactomeId" : 10258129,
    "displayName" : "OSMR",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 174,
      "y" : 1217
    },
    "minX" : 152,
    "maxX" : 389,
    "minY" : 1054,
    "maxY" : 1228,
    "prop" : {
      "x" : 152,
      "y" : 1206,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 152,
      "y" : 1206
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 196,
          "y" : 1206
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 196,
          "y" : 1206
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21402,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 188,
          "y" : 1203
        },
        "to" : {
          "x" : 389,
          "y" : 1054
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21404,
    "reactomeId" : 10298446,
    "displayName" : "JAKs:OSMR",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 174,
      "y" : 1160
    },
    "minX" : 137,
    "maxX" : 218,
    "minY" : 1143,
    "maxY" : 1171,
    "prop" : {
      "x" : 137,
      "y" : 1149,
      "width" : 75,
      "height" : 22
    },
    "textPosition" : {
      "x" : 138,
      "y" : 1150
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 212,
          "y" : 1149
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 212,
          "y" : 1149
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21402,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21406,
    "reactomeId" : 10297429,
    "displayName" : "CTF1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 128,
      "y" : 727
    },
    "minX" : 109,
    "maxX" : 311,
    "minY" : 710,
    "maxY" : 738,
    "prop" : {
      "x" : 109,
      "y" : 716,
      "width" : 39,
      "height" : 22
    },
    "textPosition" : {
      "x" : 109,
      "y" : 716
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 148,
          "y" : 716
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 148,
          "y" : 716
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21405,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 151,
          "y" : 727
        },
        "to" : {
          "x" : 311,
          "y" : 727
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21407,
    "reactomeId" : 10297437,
    "displayName" : "CTF1:LIFR:JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 176,
      "y" : 769
    },
    "minX" : 128,
    "maxX" : 231,
    "minY" : 752,
    "maxY" : 780,
    "prop" : {
      "x" : 128,
      "y" : 758,
      "width" : 97,
      "height" : 22
    },
    "textPosition" : {
      "x" : 129,
      "y" : 759
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 225,
          "y" : 758
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 225,
          "y" : 758
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21405,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21409,
    "reactomeId" : 10258432,
    "displayName" : "IL11",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1029,
      "y" : 187
    },
    "minX" : 997,
    "maxX" : 1052,
    "minY" : 170,
    "maxY" : 212,
    "prop" : {
      "x" : 1012,
      "y" : 176,
      "width" : 34,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1012,
      "y" : 176
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1046,
          "y" : 176
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1046,
          "y" : 176
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21408,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1014,
          "y" : 201
        },
        "to" : {
          "x" : 997,
          "y" : 212
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21410,
    "reactomeId" : 10258436,
    "displayName" : "IL11RA",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1024,
      "y" : 248
    },
    "minX" : 997,
    "maxX" : 1055,
    "minY" : 212,
    "maxY" : 259,
    "prop" : {
      "x" : 999,
      "y" : 237,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 999,
      "y" : 237
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1049,
          "y" : 237
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1049,
          "y" : 237
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21408,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1015,
          "y" : 234
        },
        "to" : {
          "x" : 997,
          "y" : 212
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21411,
    "reactomeId" : 10258438,
    "displayName" : "IL11RA:IL11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 901,
      "y" : 249
    },
    "minX" : 862,
    "maxX" : 947,
    "minY" : 153,
    "maxY" : 260,
    "prop" : {
      "x" : 862,
      "y" : 238,
      "width" : 79,
      "height" : 22
    },
    "textPosition" : {
      "x" : 862,
      "y" : 239
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 941,
          "y" : 238
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 941,
          "y" : 238
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21408,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21412,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 903,
          "y" : 235
        },
        "to" : {
          "x" : 926,
          "y" : 153
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21413,
    "reactomeId" : 10258460,
    "displayName" : "IL6RA:IL6:IL6RB:JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1141,
      "y" : 242
    },
    "minX" : 1106,
    "maxX" : 1183,
    "minY" : 218,
    "maxY" : 260,
    "prop" : {
      "x" : 1106,
      "y" : 224,
      "width" : 71,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1106,
      "y" : 225
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1177,
          "y" : 224
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1177,
          "y" : 224
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21412,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21415,
    "reactomeId" : 10258131,
    "displayName" : "OSMR:JAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 260,
      "y" : 1272
    },
    "minX" : 213,
    "maxX" : 461,
    "minY" : 1254,
    "maxY" : 1398,
    "prop" : {
      "x" : 213,
      "y" : 1260,
      "width" : 94,
      "height" : 24
    },
    "textPosition" : {
      "x" : 223,
      "y" : 1263
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 307,
          "y" : 1260
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 307,
          "y" : 1260
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21414,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 279,
          "y" : 1287
        },
        "to" : {
          "x" : 461,
          "y" : 1398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21416,
    "reactomeId" : 10258125,
    "displayName" : "IL31:IL31RA:JAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 586,
      "y" : 1272
    },
    "minX" : 461,
    "maxX" : 654,
    "minY" : 1255,
    "maxY" : 1398,
    "prop" : {
      "x" : 525,
      "y" : 1261,
      "width" : 123,
      "height" : 23
    },
    "textPosition" : {
      "x" : 532,
      "y" : 1263
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 648,
          "y" : 1261
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 648,
          "y" : 1261
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21414,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 574,
          "y" : 1287
        },
        "to" : {
          "x" : 461,
          "y" : 1398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21417,
    "reactomeId" : 10258133,
    "displayName" : "IL31:IL31RA:JAK1:OSMR:JAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 720,
      "y" : 1275
    },
    "minX" : 663,
    "maxX" : 784,
    "minY" : 1251,
    "maxY" : 1293,
    "prop" : {
      "x" : 663,
      "y" : 1257,
      "width" : 115,
      "height" : 36
    },
    "textPosition" : {
      "x" : 664,
      "y" : 1258
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 778,
          "y" : 1257
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 778,
          "y" : 1257
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21414,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21419,
    "reactomeId" : 9715042,
    "displayName" : "IL6R inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 173,
      "y" : 156
    },
    "minX" : 128,
    "maxX" : 255,
    "minY" : 145,
    "maxY" : 190,
    "prop" : {
      "x" : 128,
      "y" : 145,
      "width" : 91,
      "height" : 22
    },
    "textPosition" : {
      "x" : 140,
      "y" : 139
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 21418,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 199,
          "y" : 173
        },
        "to" : {
          "x" : 255,
          "y" : 190
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21319,
    "reactomeId" : 10233464,
    "displayName" : "IL6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 308,
      "y" : 128
    },
    "minX" : 287,
    "maxX" : 413,
    "minY" : 99,
    "maxY" : 204,
    "prop" : {
      "x" : 287,
      "y" : 115,
      "width" : 42,
      "height" : 26
    },
    "textPosition" : {
      "x" : 295,
      "y" : 117
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 329,
          "y" : 115
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 329,
          "y" : 115
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21318,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 332,
          "y" : 122
        },
        "to" : {
          "x" : 413,
          "y" : 99
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21325,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 312,
          "y" : 144
        },
        "to" : {
          "x" : 334,
          "y" : 204
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21320,
    "reactomeId" : 10233502,
    "displayName" : "IL6R",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 350,
      "y" : 56
    },
    "minX" : 317,
    "maxX" : 413,
    "minY" : 36,
    "maxY" : 99,
    "prop" : {
      "x" : 317,
      "y" : 42,
      "width" : 66,
      "height" : 29
    },
    "textPosition" : {
      "x" : 333,
      "y" : 46
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 383,
          "y" : 42
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 383,
          "y" : 42
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21318,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 371,
          "y" : 74
        },
        "to" : {
          "x" : 413,
          "y" : 99
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21321,
    "reactomeId" : 10233504,
    "displayName" : "IL6:IL6R-2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 604,
      "y" : 100
    },
    "minX" : 566,
    "maxX" : 730,
    "minY" : 58,
    "maxY" : 171,
    "prop" : {
      "x" : 566,
      "y" : 87,
      "width" : 76,
      "height" : 27
    },
    "textPosition" : {
      "x" : 571,
      "y" : 93
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 642,
          "y" : 87
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 642,
          "y" : 87
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21318,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21322,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 618,
          "y" : 84
        },
        "to" : {
          "x" : 648,
          "y" : 58
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21329,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 627,
          "y" : 117
        },
        "to" : {
          "x" : 730,
          "y" : 171
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21323,
    "reactomeId" : 10265368,
    "displayName" : "IL6ST",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 608,
      "y" : 19
    },
    "minX" : 578,
    "maxX" : 648,
    "minY" : 0,
    "maxY" : 58,
    "prop" : {
      "x" : 578,
      "y" : 6,
      "width" : 61,
      "height" : 27
    },
    "textPosition" : {
      "x" : 588,
      "y" : 9
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 639,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 639,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21322,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 621,
          "y" : 36
        },
        "to" : {
          "x" : 648,
          "y" : 58
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21324,
    "reactomeId" : 10265370,
    "displayName" : "IL6:IL6R-2:IL6ST-2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 770,
      "y" : 57
    },
    "minX" : 711,
    "maxX" : 836,
    "minY" : 38,
    "maxY" : 162,
    "prop" : {
      "x" : 711,
      "y" : 44,
      "width" : 119,
      "height" : 27
    },
    "textPosition" : {
      "x" : 713,
      "y" : 50
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 830,
          "y" : 44
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 830,
          "y" : 44
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21322,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21329,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 769,
          "y" : 74
        },
        "to" : {
          "x" : 769,
          "y" : 162
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 765,
          "y" : 162
        },
        "b" : {
          "x" : 773,
          "y" : 162
        },
        "c" : {
          "x" : 769,
          "y" : 162
        },
        "type" : "STOP",
        "centre" : {
          "x" : 769,
          "y" : 162
        }
      }
    } ]
  }, {
    "id" : 21326,
    "reactomeId" : 10233468,
    "displayName" : "IL6R",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 267,
      "y" : 247
    },
    "minX" : 241,
    "maxX" : 334,
    "minY" : 190,
    "maxY" : 259,
    "prop" : {
      "x" : 241,
      "y" : 235,
      "width" : 53,
      "height" : 24
    },
    "textPosition" : {
      "x" : 251,
      "y" : 236
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 294,
          "y" : 235
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 294,
          "y" : 235
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21325,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 285,
          "y" : 232
        },
        "to" : {
          "x" : 334,
          "y" : 204
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21418,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 264,
          "y" : 232
        },
        "to" : {
          "x" : 255,
          "y" : 190
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21327,
    "reactomeId" : 10233470,
    "displayName" : "IL6:IL6R",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 453,
      "y" : 251
    },
    "minX" : 420,
    "maxX" : 561,
    "minY" : 233,
    "maxY" : 299,
    "prop" : {
      "x" : 420,
      "y" : 239,
      "width" : 66,
      "height" : 24
    },
    "textPosition" : {
      "x" : 426,
      "y" : 242
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 486,
          "y" : 239
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 486,
          "y" : 239
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21325,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21332,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 480,
          "y" : 266
        },
        "to" : {
          "x" : 561,
          "y" : 299
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21328,
    "reactomeId" : 10265383,
    "displayName" : "IL6R:IL6R inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 358,
      "y" : 251
    },
    "minX" : 310,
    "maxX" : 412,
    "minY" : 210,
    "maxY" : 270,
    "prop" : {
      "x" : 310,
      "y" : 232,
      "width" : 96,
      "height" : 38
    },
    "textPosition" : {
      "x" : 325,
      "y" : 235
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 406,
          "y" : 232
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 406,
          "y" : 232
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21325,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 364,
          "y" : 229
        },
        "to" : {
          "x" : 371,
          "y" : 211
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 367,
          "y" : 210
        },
        "b" : {
          "x" : 375,
          "y" : 212
        },
        "c" : {
          "x" : 371,
          "y" : 211
        },
        "type" : "STOP",
        "centre" : {
          "x" : 371,
          "y" : 211
        }
      }
    }, {
      "edgeId" : 21418,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21330,
    "reactomeId" : 10258063,
    "displayName" : "IL6ST:JAK1, JAK2, (TYK2)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 552,
      "y" : 246
    },
    "minX" : 280,
    "maxX" : 926,
    "minY" : 153,
    "maxY" : 673,
    "prop" : {
      "x" : 510,
      "y" : 228,
      "width" : 85,
      "height" : 37
    },
    "textPosition" : {
      "x" : 512,
      "y" : 230
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 595,
          "y" : 228
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 595,
          "y" : 228
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21382,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 540,
          "y" : 268
        },
        "to" : {
          "x" : 280,
          "y" : 673
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21329,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 595,
          "y" : 225
        },
        "to" : {
          "x" : 730,
          "y" : 171
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21332,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 555,
          "y" : 268
        },
        "to" : {
          "x" : 561,
          "y" : 299
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21412,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 598,
          "y" : 235
        },
        "to" : {
          "x" : 926,
          "y" : 153
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21331,
    "reactomeId" : 10265366,
    "displayName" : "IL6:sIL6R:IL6RB:JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 791,
      "y" : 250
    },
    "minX" : 744,
    "maxX" : 845,
    "minY" : 226,
    "maxY" : 269,
    "prop" : {
      "x" : 744,
      "y" : 232,
      "width" : 95,
      "height" : 37
    },
    "textPosition" : {
      "x" : 756,
      "y" : 234
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 839,
          "y" : 232
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 839,
          "y" : 232
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21329,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21333,
    "reactomeId" : 10265375,
    "displayName" : "IL6:IL6RA:IL6RB:JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 667,
      "y" : 250
    },
    "minX" : 626,
    "maxX" : 715,
    "minY" : 227,
    "maxY" : 268,
    "prop" : {
      "x" : 626,
      "y" : 233,
      "width" : 83,
      "height" : 35
    },
    "textPosition" : {
      "x" : 632,
      "y" : 233
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 709,
          "y" : 233
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 709,
          "y" : 233
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21332,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21335,
    "reactomeId" : 10265377,
    "displayName" : "IL6 receptor trimer:JAKs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1279,
      "y" : 251
    },
    "minX" : 1215,
    "maxX" : 1347,
    "minY" : 206,
    "maxY" : 269,
    "prop" : {
      "x" : 1215,
      "y" : 233,
      "width" : 128,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1215,
      "y" : 233
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 21334,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1335,
            "y" : 206
          },
          "b" : {
            "x" : 1347,
            "y" : 218
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1341,
            "y" : 212
          }
        }
      }
    } ]
  }, {
    "id" : 21336,
    "reactomeId" : 10265379,
    "displayName" : "IL6 receptor hexamer:JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1408,
      "y" : 253
    },
    "minX" : 1358,
    "maxX" : 1465,
    "minY" : 228,
    "maxY" : 296,
    "prop" : {
      "x" : 1358,
      "y" : 234,
      "width" : 101,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1363,
      "y" : 237
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1459,
          "y" : 234
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1459,
          "y" : 234
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21334,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21337,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1422,
          "y" : 275
        },
        "to" : {
          "x" : 1440,
          "y" : 296
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21338,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1401,
      "y" : 340
    },
    "minX" : 1381,
    "maxX" : 1440,
    "minY" : 296,
    "maxY" : 355,
    "prop" : {
      "x" : 1381,
      "y" : 325,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1385,
      "y" : 329
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1416,
          "y" : 330
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1416,
          "y" : 330
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21337,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1414,
          "y" : 322
        },
        "to" : {
          "x" : 1440,
          "y" : 296
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 1421,
            "y" : 303
          },
          "b" : {
            "x" : 1433,
            "y" : 315
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1427,
            "y" : 309
          }
        }
      }
    } ]
  }, {
    "id" : 21339,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1553,
      "y" : 337
    },
    "minX" : 1505,
    "maxX" : 1575,
    "minY" : 296,
    "maxY" : 352,
    "prop" : {
      "x" : 1533,
      "y" : 322,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1537,
      "y" : 326
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1569,
          "y" : 327
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1569,
          "y" : 327
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21337,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1535,
          "y" : 319
        },
        "to" : {
          "x" : 1505,
          "y" : 296
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 1514,
            "y" : 301
          },
          "b" : {
            "x" : 1526,
            "y" : 313
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1520,
            "y" : 307
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1527,
          "y" : 318
        },
        "b" : {
          "x" : 1535,
          "y" : 319
        },
        "c" : {
          "x" : 1532,
          "y" : 312
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1532,
          "y" : 312
        }
      }
    } ]
  }, {
    "id" : 21340,
    "reactomeId" : 10265400,
    "displayName" : "IL6 receptor hexamer:Activated JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1615,
      "y" : 250
    },
    "minX" : 1505,
    "maxX" : 1689,
    "minY" : 219,
    "maxY" : 297,
    "prop" : {
      "x" : 1547,
      "y" : 225,
      "width" : 136,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1551,
      "y" : 226
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1683,
          "y" : 225
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1683,
          "y" : 225
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21337,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1555,
          "y" : 278
        },
        "to" : {
          "x" : 1505,
          "y" : 296
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1550,
          "y" : 284
        },
        "b" : {
          "x" : 1555,
          "y" : 278
        },
        "c" : {
          "x" : 1547,
          "y" : 277
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1547,
          "y" : 277
        }
      }
    }, {
      "edgeId" : 21341,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1636,
          "y" : 278
        },
        "to" : {
          "x" : 1656,
          "y" : 297
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21342,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1631,
      "y" : 333
    },
    "minX" : 1611,
    "maxX" : 1656,
    "minY" : 297,
    "maxY" : 348,
    "prop" : {
      "x" : 1611,
      "y" : 318,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1615,
      "y" : 322
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1646,
          "y" : 323
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1646,
          "y" : 323
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21341,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1641,
          "y" : 315
        },
        "to" : {
          "x" : 1656,
          "y" : 297
        }
      } ],
      "stoichiometry" : {
        "value" : 20,
        "shape" : {
          "a" : {
            "x" : 1642,
            "y" : 300
          },
          "b" : {
            "x" : 1654,
            "y" : 312
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1648,
            "y" : 306
          }
        }
      }
    } ]
  }, {
    "id" : 21343,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1752,
      "y" : 332
    },
    "minX" : 1718,
    "maxX" : 1774,
    "minY" : 297,
    "maxY" : 347,
    "prop" : {
      "x" : 1732,
      "y" : 317,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1736,
      "y" : 321
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1768,
          "y" : 322
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1768,
          "y" : 322
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21341,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1737,
          "y" : 314
        },
        "to" : {
          "x" : 1718,
          "y" : 297
        }
      } ],
      "stoichiometry" : {
        "value" : 20,
        "shape" : {
          "a" : {
            "x" : 1721,
            "y" : 299
          },
          "b" : {
            "x" : 1733,
            "y" : 311
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1727,
            "y" : 305
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1729,
          "y" : 312
        },
        "b" : {
          "x" : 1737,
          "y" : 314
        },
        "c" : {
          "x" : 1735,
          "y" : 306
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1735,
          "y" : 306
        }
      }
    } ]
  }, {
    "id" : 21344,
    "reactomeId" : 10233510,
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1829,
      "y" : 254
    },
    "minX" : 1651,
    "maxX" : 2006,
    "minY" : 216,
    "maxY" : 685,
    "prop" : {
      "x" : 1767,
      "y" : 222,
      "width" : 124,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1765,
      "y" : 209
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1891,
          "y" : 222
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1891,
          "y" : 222
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21341,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1764,
          "y" : 278
        },
        "to" : {
          "x" : 1718,
          "y" : 297
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1759,
          "y" : 284
        },
        "b" : {
          "x" : 1764,
          "y" : 278
        },
        "c" : {
          "x" : 1756,
          "y" : 277
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1756,
          "y" : 277
        }
      }
    }, {
      "edgeId" : 21345,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1862,
          "y" : 289
        },
        "to" : {
          "x" : 2006,
          "y" : 425
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21353,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1894,
          "y" : 268
        },
        "to" : {
          "x" : 1922,
          "y" : 276
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21359,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1832,
          "y" : 289
        },
        "to" : {
          "x" : 1858,
          "y" : 503
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1837,
          "y" : 295
        },
        "b" : {
          "x" : 1832,
          "y" : 289
        },
        "c" : {
          "x" : 1829,
          "y" : 296
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1829,
          "y" : 296
        }
      }
    }, {
      "edgeId" : 21363,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1815,
          "y" : 289
        },
        "to" : {
          "x" : 1651,
          "y" : 685
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21346,
    "reactomeId" : 10265419,
    "displayName" : "STAT1, STAT3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1979,
      "y" : 482
    },
    "minX" : 1933,
    "maxX" : 2026,
    "minY" : 425,
    "maxY" : 493,
    "prop" : {
      "x" : 1933,
      "y" : 471,
      "width" : 93,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1933,
      "y" : 471
    },
    "connectors" : [ {
      "edgeId" : 21345,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1984,
          "y" : 465
        },
        "to" : {
          "x" : 2006,
          "y" : 425
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21347,
    "reactomeId" : 10265421,
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2622,
      "y" : 433
    },
    "minX" : 2560,
    "maxX" : 2690,
    "minY" : 388,
    "maxY" : 547,
    "prop" : {
      "x" : 2560,
      "y" : 394,
      "width" : 124,
      "height" : 78
    },
    "textPosition" : {
      "x" : 2558,
      "y" : 395
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2684,
          "y" : 394
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2684,
          "y" : 394
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21345,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21348,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2602,
          "y" : 475
        },
        "to" : {
          "x" : 2583,
          "y" : 513
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21348,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2622,
          "y" : 475
        },
        "to" : {
          "x" : 2623,
          "y" : 520
        }
      }, {
        "from" : {
          "x" : 2623,
          "y" : 520
        },
        "to" : {
          "x" : 2596,
          "y" : 540
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2593,
          "y" : 543
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2593,
          "y" : 543
        }
      }
    } ]
  }, {
    "id" : 21349,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2513,
      "y" : 489
    },
    "minX" : 2493,
    "maxX" : 2583,
    "minY" : 473,
    "maxY" : 513,
    "prop" : {
      "x" : 2493,
      "y" : 474,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2497,
      "y" : 478
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2528,
          "y" : 479
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2528,
          "y" : 479
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21348,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2536,
          "y" : 495
        },
        "to" : {
          "x" : 2583,
          "y" : 513
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2553,
            "y" : 498
          },
          "b" : {
            "x" : 2565,
            "y" : 510
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2559,
            "y" : 504
          }
        }
      }
    } ]
  }, {
    "id" : 21350,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2505,
      "y" : 592
    },
    "minX" : 2486,
    "maxX" : 2583,
    "minY" : 573,
    "maxY" : 611,
    "prop" : {
      "x" : 2486,
      "y" : 574,
      "width" : 39,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2489,
      "y" : 582
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2520,
          "y" : 579
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2520,
          "y" : 579
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21348,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2528,
          "y" : 588
        },
        "to" : {
          "x" : 2583,
          "y" : 579
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2549,
            "y" : 577
          },
          "b" : {
            "x" : 2561,
            "y" : 589
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2555,
            "y" : 583
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2534,
          "y" : 583
        },
        "b" : {
          "x" : 2528,
          "y" : 588
        },
        "c" : {
          "x" : 2535,
          "y" : 591
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2535,
          "y" : 591
        }
      }
    } ]
  }, {
    "id" : 21351,
    "reactomeId" : 10265439,
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2632,
      "y" : 637
    },
    "minX" : 2537,
    "maxX" : 2733,
    "minY" : 579,
    "maxY" : 709,
    "prop" : {
      "x" : 2537,
      "y" : 605,
      "width" : 190,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2537,
      "y" : 606
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2727,
          "y" : 605
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2727,
          "y" : 605
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21348,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2604,
          "y" : 602
        },
        "to" : {
          "x" : 2583,
          "y" : 579
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2596,
          "y" : 600
        },
        "b" : {
          "x" : 2604,
          "y" : 602
        },
        "c" : {
          "x" : 2602,
          "y" : 594
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2602,
          "y" : 594
        }
      }
    }, {
      "edgeId" : 21355,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2617,
          "y" : 672
        },
        "to" : {
          "x" : 2599,
          "y" : 709
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21359,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21352,
    "reactomeId" : 10265442,
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2045,
      "y" : 255
    },
    "minX" : 1983,
    "maxX" : 2574,
    "minY" : 210,
    "maxY" : 554,
    "prop" : {
      "x" : 1983,
      "y" : 216,
      "width" : 124,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1981,
      "y" : 217
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2107,
          "y" : 216
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2107,
          "y" : 216
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21348,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2110,
          "y" : 274
        },
        "to" : {
          "x" : 2462,
          "y" : 387
        }
      }, {
        "from" : {
          "x" : 2462,
          "y" : 387
        },
        "to" : {
          "x" : 2463,
          "y" : 546
        }
      }, {
        "from" : {
          "x" : 2463,
          "y" : 546
        },
        "to" : {
          "x" : 2574,
          "y" : 550
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2574,
          "y" : 554
        },
        "b" : {
          "x" : 2574,
          "y" : 546
        },
        "c" : {
          "x" : 2574,
          "y" : 550
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2574,
          "y" : 550
        }
      }
    }, {
      "edgeId" : 21353,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21354,
    "reactomeId" : 10260693,
    "displayName" : "SOCS3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1916,
      "y" : 298
    },
    "minX" : 1893,
    "maxX" : 1945,
    "minY" : 276,
    "maxY" : 309,
    "prop" : {
      "x" : 1893,
      "y" : 287,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1895,
      "y" : 281
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1939,
          "y" : 287
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1939,
          "y" : 287
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21353,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1919,
          "y" : 284
        },
        "to" : {
          "x" : 1922,
          "y" : 276
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21356,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2511,
      "y" : 694
    },
    "minX" : 2491,
    "maxX" : 2599,
    "minY" : 678,
    "maxY" : 709,
    "prop" : {
      "x" : 2491,
      "y" : 679,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2495,
      "y" : 683
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2526,
          "y" : 684
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2526,
          "y" : 684
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21355,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2534,
          "y" : 697
        },
        "to" : {
          "x" : 2599,
          "y" : 709
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2560,
            "y" : 697
          },
          "b" : {
            "x" : 2572,
            "y" : 709
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2566,
            "y" : 703
          }
        }
      }
    } ]
  }, {
    "id" : 21357,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2501,
      "y" : 832
    },
    "minX" : 2481,
    "maxX" : 2599,
    "minY" : 767,
    "maxY" : 847,
    "prop" : {
      "x" : 2481,
      "y" : 817,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2485,
      "y" : 821
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2517,
          "y" : 822
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2517,
          "y" : 822
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21355,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2525,
          "y" : 818
        },
        "to" : {
          "x" : 2599,
          "y" : 767
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2556,
            "y" : 786
          },
          "b" : {
            "x" : 2568,
            "y" : 798
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2562,
            "y" : 792
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2528,
          "y" : 811
        },
        "b" : {
          "x" : 2525,
          "y" : 818
        },
        "c" : {
          "x" : 2533,
          "y" : 817
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2533,
          "y" : 817
        }
      }
    } ]
  }, {
    "id" : 21358,
    "reactomeId" : 10265488,
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2633,
      "y" : 845
    },
    "minX" : 2546,
    "maxX" : 2727,
    "minY" : 767,
    "maxY" : 880,
    "prop" : {
      "x" : 2546,
      "y" : 810,
      "width" : 175,
      "height" : 70
    },
    "textPosition" : {
      "x" : 2550,
      "y" : 803
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2721,
          "y" : 810
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2721,
          "y" : 810
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21355,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2617,
          "y" : 807
        },
        "to" : {
          "x" : 2599,
          "y" : 767
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2611,
          "y" : 802
        },
        "b" : {
          "x" : 2617,
          "y" : 807
        },
        "c" : {
          "x" : 2618,
          "y" : 799
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2618,
          "y" : 799
        }
      }
    } ]
  }, {
    "id" : 21360,
    "reactomeId" : 10265409,
    "displayName" : "p-Y701-STAT1, p-Y705-STAT3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2081,
      "y" : 667
    },
    "minX" : 1858,
    "maxX" : 2143,
    "minY" : 503,
    "maxY" : 731,
    "prop" : {
      "x" : 2019,
      "y" : 642,
      "width" : 124,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2024,
      "y" : 649
    },
    "connectors" : [ {
      "edgeId" : 21359,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2047,
          "y" : 636
        },
        "to" : {
          "x" : 1858,
          "y" : 503
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2039,
          "y" : 635
        },
        "b" : {
          "x" : 2047,
          "y" : 636
        },
        "c" : {
          "x" : 2044,
          "y" : 629
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2044,
          "y" : 629
        }
      }
    }, {
      "edgeId" : 21361,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 2075,
            "y" : 719
          },
          "b" : {
            "x" : 2087,
            "y" : 731
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2081,
            "y" : 725
          }
        }
      }
    } ]
  }, {
    "id" : 21362,
    "reactomeId" : 10265415,
    "displayName" : "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2085,
      "y" : 824
    },
    "minX" : 2020,
    "maxX" : 2150,
    "minY" : 785,
    "maxY" : 864,
    "prop" : {
      "x" : 2020,
      "y" : 785,
      "width" : 130,
      "height" : 79
    },
    "textPosition" : {
      "x" : 2034,
      "y" : 786
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 21361,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21373,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21364,
    "reactomeId" : 10238034,
    "displayName" : "PTPN11",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1714,
      "y" : 654
    },
    "minX" : 1651,
    "maxX" : 1748,
    "minY" : 637,
    "maxY" : 685,
    "prop" : {
      "x" : 1686,
      "y" : 643,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1686,
      "y" : 643
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1742,
          "y" : 643
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1742,
          "y" : 643
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21363,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1691,
          "y" : 668
        },
        "to" : {
          "x" : 1651,
          "y" : 685
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21365,
    "reactomeId" : 10265472,
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1594,
      "y" : 879
    },
    "minX" : 1471,
    "maxX" : 1725,
    "minY" : 835,
    "maxY" : 918,
    "prop" : {
      "x" : 1531,
      "y" : 841,
      "width" : 126,
      "height" : 77
    },
    "textPosition" : {
      "x" : 1530,
      "y" : 841
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1657,
          "y" : 841
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1657,
          "y" : 841
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21363,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21366,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1660,
          "y" : 857
        },
        "to" : {
          "x" : 1695,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21366,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1660,
          "y" : 897
        },
        "to" : {
          "x" : 1720,
          "y" : 916
        }
      }, {
        "from" : {
          "x" : 1720,
          "y" : 916
        },
        "to" : {
          "x" : 1721,
          "y" : 861
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1721,
          "y" : 857
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1721,
          "y" : 857
        }
      }
    }, {
      "edgeId" : 21370,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1528,
          "y" : 861
        },
        "to" : {
          "x" : 1471,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21367,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1660,
      "y" : 804
    },
    "minX" : 1640,
    "maxX" : 1695,
    "minY" : 788,
    "maxY" : 845,
    "prop" : {
      "x" : 1640,
      "y" : 789,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1644,
      "y" : 793
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1675,
          "y" : 794
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1675,
          "y" : 794
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21366,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1672,
          "y" : 822
        },
        "to" : {
          "x" : 1695,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1677,
            "y" : 827
          },
          "b" : {
            "x" : 1689,
            "y" : 839
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1683,
            "y" : 833
          }
        }
      }
    } ]
  }, {
    "id" : 21368,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1805,
      "y" : 798
    },
    "minX" : 1750,
    "maxX" : 1827,
    "minY" : 782,
    "maxY" : 845,
    "prop" : {
      "x" : 1785,
      "y" : 783,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1789,
      "y" : 787
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1821,
          "y" : 788
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1821,
          "y" : 788
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21366,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1787,
          "y" : 816
        },
        "to" : {
          "x" : 1750,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1762,
            "y" : 824
          },
          "b" : {
            "x" : 1774,
            "y" : 836
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1768,
            "y" : 830
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1784,
          "y" : 823
        },
        "b" : {
          "x" : 1787,
          "y" : 816
        },
        "c" : {
          "x" : 1779,
          "y" : 817
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1779,
          "y" : 817
        }
      }
    } ]
  }, {
    "id" : 21369,
    "reactomeId" : 10233512,
    "displayName" : "IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1865,
      "y" : 884
    },
    "minX" : 1750,
    "maxX" : 1957,
    "minY" : 839,
    "maxY" : 924,
    "prop" : {
      "x" : 1780,
      "y" : 845,
      "width" : 171,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1786,
      "y" : 847
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1951,
          "y" : 845
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1951,
          "y" : 845
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21366,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1777,
          "y" : 855
        },
        "to" : {
          "x" : 1750,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1769,
          "y" : 856
        },
        "b" : {
          "x" : 1777,
          "y" : 855
        },
        "c" : {
          "x" : 1772,
          "y" : 849
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1772,
          "y" : 849
        }
      }
    } ]
  }, {
    "id" : 21371,
    "reactomeId" : 10240822,
    "displayName" : "CBL",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1509,
      "y" : 802
    },
    "minX" : 1471,
    "maxX" : 1530,
    "minY" : 785,
    "maxY" : 845,
    "prop" : {
      "x" : 1494,
      "y" : 791,
      "width" : 30,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1494,
      "y" : 791
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1524,
          "y" : 791
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1524,
          "y" : 791
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21370,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1499,
          "y" : 816
        },
        "to" : {
          "x" : 1471,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21372,
    "reactomeId" : 10265474,
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1285,
      "y" : 850
    },
    "minX" : 1196,
    "maxX" : 1381,
    "minY" : 816,
    "maxY" : 878,
    "prop" : {
      "x" : 1196,
      "y" : 822,
      "width" : 179,
      "height" : 56
    },
    "textPosition" : {
      "x" : 1199,
      "y" : 829
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1375,
          "y" : 822
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1375,
          "y" : 822
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 21370,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21374,
    "reactomeId" : 10265435,
    "displayName" : "STAT1/3 homo and heterodimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2085,
      "y" : 1020
    },
    "minX" : 2024,
    "maxX" : 2146,
    "minY" : 995,
    "maxY" : 1045,
    "prop" : {
      "x" : 2024,
      "y" : 995,
      "width" : 122,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2025,
      "y" : 1002
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 21373,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 21379,
    "reactomeId" : 10297457,
    "displayName" : "CRLF1:CLCF1 binds CNTRF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2432,
      "y" : 329
    },
    "minX" : 2392,
    "maxX" : 2526,
    "minY" : 262,
    "maxY" : 335,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2392,
        "y" : 330
      },
      "to" : {
        "x" : 2432,
        "y" : 329
      }
    }, {
      "from" : {
        "x" : 2432,
        "y" : 329
      },
      "to" : {
        "x" : 2526,
        "y" : 262
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2523,
        "y" : 269
      },
      "b" : {
        "x" : 2526,
        "y" : 262
      },
      "c" : {
        "x" : 2518,
        "y" : 263
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2518,
        "y" : 263
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2432,
        "y" : 329
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2432,
        "y" : 329
      }
    },
    "inputs" : [ {
      "id" : 21378,
      "points" : [ {
        "x" : 2418,
        "y" : 261
      } ]
    }, {
      "id" : 21380,
      "points" : [ {
        "x" : 2186,
        "y" : 259
      } ]
    } ],
    "outputs" : [ {
      "id" : 21381
    } ]
  }, {
    "id" : 21382,
    "reactomeId" : 10298460,
    "displayName" : "gp130:JAKs bind CNTFR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 280,
      "y" : 516
    },
    "minX" : 262,
    "maxX" : 286,
    "minY" : 509,
    "maxY" : 673,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 280,
        "y" : 673
      },
      "to" : {
        "x" : 280,
        "y" : 516
      }
    }, {
      "from" : {
        "x" : 280,
        "y" : 516
      },
      "to" : {
        "x" : 262,
        "y" : 509
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 270,
        "y" : 508
      },
      "b" : {
        "x" : 262,
        "y" : 509
      },
      "c" : {
        "x" : 267,
        "y" : 515
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 267,
        "y" : 515
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 280,
        "y" : 516
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 280,
        "y" : 516
      }
    },
    "inputs" : [ {
      "id" : 21330,
      "points" : [ {
        "x" : 540,
        "y" : 268
      } ]
    }, {
      "id" : 21383,
      "points" : [ {
        "x" : 242,
        "y" : 673
      } ]
    } ],
    "outputs" : [ {
      "id" : 21384
    } ]
  }, {
    "id" : 21318,
    "reactomeId" : 10265364,
    "displayName" : "IL6 binds IL6R-2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 414,
      "y" : 99
    },
    "minX" : 408,
    "maxX" : 563,
    "minY" : 93,
    "maxY" : 105,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 413,
        "y" : 99
      },
      "to" : {
        "x" : 414,
        "y" : 99
      }
    }, {
      "from" : {
        "x" : 414,
        "y" : 99
      },
      "to" : {
        "x" : 563,
        "y" : 99
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 556,
        "y" : 103
      },
      "b" : {
        "x" : 563,
        "y" : 99
      },
      "c" : {
        "x" : 556,
        "y" : 95
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 556,
        "y" : 95
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 414,
        "y" : 99
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 414,
        "y" : 99
      }
    },
    "inputs" : [ {
      "id" : 21319,
      "points" : [ {
        "x" : 332,
        "y" : 122
      } ]
    }, {
      "id" : 21320,
      "points" : [ {
        "x" : 371,
        "y" : 74
      } ]
    } ],
    "outputs" : [ {
      "id" : 21321
    } ]
  }, {
    "id" : 21385,
    "reactomeId" : 10298521,
    "displayName" : "JAKs bind LIFR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 220,
      "y" : 367
    },
    "minX" : 201,
    "maxX" : 226,
    "minY" : 340,
    "maxY" : 373,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 221,
        "y" : 340
      },
      "to" : {
        "x" : 220,
        "y" : 367
      }
    }, {
      "from" : {
        "x" : 220,
        "y" : 367
      },
      "to" : {
        "x" : 201,
        "y" : 373
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 206,
        "y" : 367
      },
      "b" : {
        "x" : 201,
        "y" : 373
      },
      "c" : {
        "x" : 209,
        "y" : 375
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 209,
        "y" : 375
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 220,
        "y" : 367
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 220,
        "y" : 367
      }
    },
    "inputs" : [ {
      "id" : 21386,
      "points" : [ {
        "x" : 339,
        "y" : 375
      } ]
    }, {
      "id" : 21387,
      "points" : [ {
        "x" : 188,
        "y" : 325
      } ]
    } ],
    "outputs" : [ {
      "id" : 21388
    } ]
  }, {
    "id" : 21322,
    "reactomeId" : 10265388,
    "displayName" : "IL6:IL6R-2 binds IL6ST-2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 678,
      "y" : 57
    },
    "minX" : 642,
    "maxX" : 708,
    "minY" : 52,
    "maxY" : 64,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 648,
        "y" : 58
      },
      "to" : {
        "x" : 678,
        "y" : 57
      }
    }, {
      "from" : {
        "x" : 678,
        "y" : 57
      },
      "to" : {
        "x" : 708,
        "y" : 57
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 701,
        "y" : 61
      },
      "b" : {
        "x" : 708,
        "y" : 57
      },
      "c" : {
        "x" : 701,
        "y" : 53
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 701,
        "y" : 53
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 678,
        "y" : 57
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 678,
        "y" : 57
      }
    },
    "inputs" : [ {
      "id" : 21323,
      "points" : [ {
        "x" : 621,
        "y" : 36
      } ]
    }, {
      "id" : 21321,
      "points" : [ {
        "x" : 618,
        "y" : 84
      } ]
    } ],
    "outputs" : [ {
      "id" : 21324
    } ]
  }, {
    "id" : 21325,
    "reactomeId" : 10265385,
    "displayName" : "IL6 binds IL6R",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 375,
      "y" : 203
    },
    "minX" : 334,
    "maxX" : 433,
    "minY" : 197,
    "maxY" : 236,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 334,
        "y" : 204
      },
      "to" : {
        "x" : 375,
        "y" : 203
      }
    }, {
      "from" : {
        "x" : 375,
        "y" : 203
      },
      "to" : {
        "x" : 433,
        "y" : 236
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 425,
        "y" : 236
      },
      "b" : {
        "x" : 433,
        "y" : 236
      },
      "c" : {
        "x" : 429,
        "y" : 229
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 429,
        "y" : 229
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 375,
        "y" : 203
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 375,
        "y" : 203
      }
    },
    "inputs" : [ {
      "id" : 21326,
      "points" : [ {
        "x" : 285,
        "y" : 232
      } ]
    }, {
      "id" : 21319,
      "points" : [ {
        "x" : 312,
        "y" : 144
      } ]
    } ],
    "outputs" : [ {
      "id" : 21327
    } ],
    "inhibitors" : [ {
      "id" : 21328,
      "points" : [ {
        "x" : 364,
        "y" : 229
      } ]
    } ]
  }, {
    "id" : 21389,
    "reactomeId" : 10298466,
    "displayName" : "LIFR:JAKs bind gp130:JAKs:CNTFR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 296,
      "y" : 608
    },
    "minX" : 244,
    "maxX" : 302,
    "minY" : 483,
    "maxY" : 614,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 296,
        "y" : 483
      },
      "to" : {
        "x" : 296,
        "y" : 608
      }
    }, {
      "from" : {
        "x" : 296,
        "y" : 608
      },
      "to" : {
        "x" : 244,
        "y" : 608
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 251,
        "y" : 604
      },
      "b" : {
        "x" : 244,
        "y" : 608
      },
      "c" : {
        "x" : 251,
        "y" : 612
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 251,
        "y" : 612
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 296,
        "y" : 608
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 296,
        "y" : 608
      }
    },
    "inputs" : [ {
      "id" : 21388,
      "points" : [ {
        "x" : 180,
        "y" : 396
      } ]
    }, {
      "id" : 21384,
      "points" : [ {
        "x" : 262,
        "y" : 485
      } ]
    } ],
    "outputs" : [ {
      "id" : 21390
    } ]
  }, {
    "id" : 21391,
    "reactomeId" : 10298470,
    "displayName" : "LIF binds LIFR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 102,
      "y" : 420
    },
    "minX" : 96,
    "maxX" : 141,
    "minY" : 390,
    "maxY" : 430,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 101,
        "y" : 390
      },
      "to" : {
        "x" : 102,
        "y" : 420
      }
    }, {
      "from" : {
        "x" : 102,
        "y" : 420
      },
      "to" : {
        "x" : 141,
        "y" : 430
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 133,
        "y" : 432
      },
      "b" : {
        "x" : 141,
        "y" : 430
      },
      "c" : {
        "x" : 135,
        "y" : 424
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 135,
        "y" : 424
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 102,
        "y" : 420
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 102,
        "y" : 420
      }
    },
    "inputs" : [ {
      "id" : 21392,
      "points" : [ {
        "x" : 81,
        "y" : 377
      } ]
    }, {
      "id" : 21388,
      "points" : [ {
        "x" : 131,
        "y" : 385
      } ]
    } ],
    "outputs" : [ {
      "id" : 21393
    } ]
  }, {
    "id" : 21329,
    "reactomeId" : 10265372,
    "displayName" : "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 769,
      "y" : 171
    },
    "minX" : 730,
    "maxX" : 785,
    "minY" : 165,
    "maxY" : 229,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 730,
        "y" : 171
      },
      "to" : {
        "x" : 769,
        "y" : 171
      }
    }, {
      "from" : {
        "x" : 769,
        "y" : 171
      },
      "to" : {
        "x" : 785,
        "y" : 229
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 779,
        "y" : 223
      },
      "b" : {
        "x" : 785,
        "y" : 229
      },
      "c" : {
        "x" : 787,
        "y" : 221
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 787,
        "y" : 221
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 769,
        "y" : 171
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 769,
        "y" : 171
      }
    },
    "inputs" : [ {
      "id" : 21321,
      "points" : [ {
        "x" : 627,
        "y" : 117
      } ]
    }, {
      "id" : 21330,
      "points" : [ {
        "x" : 595,
        "y" : 225
      } ]
    } ],
    "outputs" : [ {
      "id" : 21331
    } ],
    "inhibitors" : [ {
      "id" : 21324,
      "points" : [ {
        "x" : 769,
        "y" : 74
      } ]
    } ]
  }, {
    "id" : 21394,
    "reactomeId" : 10298456,
    "displayName" : "OSM,LIF,CTF1 receptor complex binds gp130",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 79,
      "y" : 976
    },
    "minX" : 0,
    "maxX" : 153,
    "minY" : 877,
    "maxY" : 1070,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 6,
        "y" : 883
      },
      "to" : {
        "x" : 79,
        "y" : 976
      }
    }, {
      "from" : {
        "x" : 79,
        "y" : 976
      },
      "to" : {
        "x" : 153,
        "y" : 1070
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 146,
        "y" : 1067
      },
      "b" : {
        "x" : 153,
        "y" : 1070
      },
      "c" : {
        "x" : 152,
        "y" : 1062
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 152,
        "y" : 1062
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 79,
        "y" : 976
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 79,
        "y" : 976
      }
    },
    "inputs" : [ {
      "id" : 21395,
      "points" : [ {
        "x" : 141,
        "y" : 288
      }, {
        "x" : 6,
        "y" : 347
      } ]
    }, {
      "id" : 21396,
      "points" : [ {
        "x" : 120,
        "y" : 849
      } ]
    } ],
    "outputs" : [ {
      "id" : 21397
    } ]
  }, {
    "id" : 21332,
    "reactomeId" : 10265390,
    "displayName" : "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 595,
      "y" : 285
    },
    "minX" : 555,
    "maxX" : 629,
    "minY" : 271,
    "maxY" : 305,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 561,
        "y" : 299
      },
      "to" : {
        "x" : 595,
        "y" : 285
      }
    }, {
      "from" : {
        "x" : 595,
        "y" : 285
      },
      "to" : {
        "x" : 629,
        "y" : 271
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 624,
        "y" : 277
      },
      "b" : {
        "x" : 629,
        "y" : 271
      },
      "c" : {
        "x" : 621,
        "y" : 270
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 621,
        "y" : 270
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 595,
        "y" : 285
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 595,
        "y" : 285
      }
    },
    "inputs" : [ {
      "id" : 21327,
      "points" : [ {
        "x" : 480,
        "y" : 266
      } ]
    }, {
      "id" : 21330,
      "points" : [ {
        "x" : 555,
        "y" : 268
      } ]
    } ],
    "outputs" : [ {
      "id" : 21333
    } ]
  }, {
    "id" : 21398,
    "reactomeId" : 10298462,
    "displayName" : "OSM binds LIFR:JAKs,OSMR:JAKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 104,
      "y" : 971
    },
    "minX" : 98,
    "maxX" : 152,
    "minY" : 965,
    "maxY" : 994,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 103,
        "y" : 970
      },
      "to" : {
        "x" : 104,
        "y" : 971
      }
    }, {
      "from" : {
        "x" : 104,
        "y" : 971
      },
      "to" : {
        "x" : 152,
        "y" : 994
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 144,
        "y" : 995
      },
      "b" : {
        "x" : 152,
        "y" : 994
      },
      "c" : {
        "x" : 147,
        "y" : 987
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 147,
        "y" : 987
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 104,
        "y" : 971
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 104,
        "y" : 971
      }
    },
    "inputs" : [ {
      "id" : 21399,
      "points" : [ {
        "x" : 146,
        "y" : 953
      } ]
    }, {
      "id" : 21400,
      "points" : [ {
        "x" : 89,
        "y" : 939
      } ]
    } ],
    "outputs" : [ {
      "id" : 21401
    } ]
  }, {
    "id" : 21334,
    "reactomeId" : 10265381,
    "displayName" : "Assembly of hexameric IL-6 receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1372,
      "y" : 198
    },
    "minX" : 1310,
    "maxX" : 1395,
    "minY" : 192,
    "maxY" : 231,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1310,
        "y" : 227
      },
      "to" : {
        "x" : 1372,
        "y" : 198
      }
    }, {
      "from" : {
        "x" : 1372,
        "y" : 198
      },
      "to" : {
        "x" : 1395,
        "y" : 231
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1388,
        "y" : 228
      },
      "b" : {
        "x" : 1395,
        "y" : 231
      },
      "c" : {
        "x" : 1394,
        "y" : 223
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1394,
        "y" : 223
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1372,
        "y" : 198
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1372,
        "y" : 198
      }
    },
    "inputs" : [ {
      "id" : 21335,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 21336
    } ]
  }, {
    "id" : 21337,
    "reactomeId" : 10265404,
    "displayName" : "JAK activation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1471,
      "y" : 296
    },
    "minX" : 1440,
    "maxX" : 1505,
    "minY" : 290,
    "maxY" : 302,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1440,
        "y" : 296
      },
      "to" : {
        "x" : 1471,
        "y" : 296
      }
    }, {
      "from" : {
        "x" : 1471,
        "y" : 296
      },
      "to" : {
        "x" : 1505,
        "y" : 296
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1465,
        "y" : 290
      },
      "b" : {
        "x" : 1477,
        "y" : 302
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1471,
        "y" : 296
      }
    },
    "inputs" : [ {
      "id" : 21336,
      "points" : [ {
        "x" : 1422,
        "y" : 275
      } ]
    }, {
      "id" : 21338,
      "points" : [ {
        "x" : 1414,
        "y" : 322
      } ],
      "stoichiometry" : 12
    } ],
    "outputs" : [ {
      "id" : 21339,
      "points" : [ {
        "x" : 1535,
        "y" : 319
      } ],
      "stoichiometry" : 12
    }, {
      "id" : 21340,
      "points" : [ {
        "x" : 1555,
        "y" : 278
      } ]
    } ]
  }, {
    "id" : 21402,
    "reactomeId" : 10298523,
    "displayName" : "JAKs bind OSMR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 292,
      "y" : 1100
    },
    "minX" : 196,
    "maxX" : 395,
    "minY" : 1048,
    "maxY" : 1146,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 389,
        "y" : 1054
      },
      "to" : {
        "x" : 292,
        "y" : 1100
      }
    }, {
      "from" : {
        "x" : 292,
        "y" : 1100
      },
      "to" : {
        "x" : 196,
        "y" : 1146
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 201,
        "y" : 1139
      },
      "b" : {
        "x" : 196,
        "y" : 1146
      },
      "c" : {
        "x" : 204,
        "y" : 1147
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 204,
        "y" : 1147
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 292,
        "y" : 1100
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 292,
        "y" : 1100
      }
    },
    "inputs" : [ {
      "id" : 21403,
      "points" : [ {
        "x" : 188,
        "y" : 1203
      } ]
    }, {
      "id" : 21386,
      "points" : [ {
        "x" : 388,
        "y" : 414
      } ]
    } ],
    "outputs" : [ {
      "id" : 21404
    } ]
  }, {
    "id" : 21405,
    "reactomeId" : 10297439,
    "displayName" : "CTF1 binds LIFR:JAKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 311,
      "y" : 728
    },
    "minX" : 212,
    "maxX" : 317,
    "minY" : 722,
    "maxY" : 755,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 311,
        "y" : 727
      },
      "to" : {
        "x" : 311,
        "y" : 728
      }
    }, {
      "from" : {
        "x" : 311,
        "y" : 728
      },
      "to" : {
        "x" : 212,
        "y" : 755
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 218,
        "y" : 749
      },
      "b" : {
        "x" : 212,
        "y" : 755
      },
      "c" : {
        "x" : 220,
        "y" : 757
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 220,
        "y" : 757
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 311,
        "y" : 728
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 311,
        "y" : 728
      }
    },
    "inputs" : [ {
      "id" : 21406,
      "points" : [ {
        "x" : 151,
        "y" : 727
      } ]
    }, {
      "id" : 21388,
      "points" : [ {
        "x" : 187,
        "y" : 396
      }, {
        "x" : 311,
        "y" : 455
      } ]
    } ],
    "outputs" : [ {
      "id" : 21407
    } ]
  }, {
    "id" : 21341,
    "reactomeId" : 10265402,
    "displayName" : "IL6ST is tyrosine phosphorylated",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1686,
      "y" : 297
    },
    "minX" : 1656,
    "maxX" : 1718,
    "minY" : 291,
    "maxY" : 303,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1656,
        "y" : 297
      },
      "to" : {
        "x" : 1686,
        "y" : 297
      }
    }, {
      "from" : {
        "x" : 1686,
        "y" : 297
      },
      "to" : {
        "x" : 1718,
        "y" : 297
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1680,
        "y" : 291
      },
      "b" : {
        "x" : 1692,
        "y" : 303
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1686,
        "y" : 297
      }
    },
    "inputs" : [ {
      "id" : 21342,
      "points" : [ {
        "x" : 1641,
        "y" : 315
      } ],
      "stoichiometry" : 20
    }, {
      "id" : 21340,
      "points" : [ {
        "x" : 1636,
        "y" : 278
      } ]
    } ],
    "outputs" : [ {
      "id" : 21343,
      "points" : [ {
        "x" : 1737,
        "y" : 314
      } ],
      "stoichiometry" : 20
    }, {
      "id" : 21344,
      "points" : [ {
        "x" : 1764,
        "y" : 278
      } ]
    } ]
  }, {
    "id" : 21408,
    "reactomeId" : 10258440,
    "displayName" : "IL11 binds IL11RA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 964,
      "y" : 213
    },
    "minX" : 920,
    "maxX" : 997,
    "minY" : 207,
    "maxY" : 235,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 997,
        "y" : 212
      },
      "to" : {
        "x" : 964,
        "y" : 213
      }
    }, {
      "from" : {
        "x" : 964,
        "y" : 213
      },
      "to" : {
        "x" : 920,
        "y" : 235
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 924,
        "y" : 228
      },
      "b" : {
        "x" : 920,
        "y" : 235
      },
      "c" : {
        "x" : 928,
        "y" : 235
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 928,
        "y" : 235
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 964,
        "y" : 213
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 964,
        "y" : 213
      }
    },
    "inputs" : [ {
      "id" : 21409,
      "points" : [ {
        "x" : 1014,
        "y" : 201
      } ]
    }, {
      "id" : 21410,
      "points" : [ {
        "x" : 1015,
        "y" : 234
      } ]
    } ],
    "outputs" : [ {
      "id" : 21411
    } ]
  }, {
    "id" : 21345,
    "reactomeId" : 10265423,
    "displayName" : "Tyrosine phosphorylated IL6ST binds STAT1,STAT3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2365,
      "y" : 429
    },
    "minX" : 2006,
    "maxX" : 2557,
    "minY" : 423,
    "maxY" : 435,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2006,
        "y" : 425
      },
      "to" : {
        "x" : 2365,
        "y" : 429
      }
    }, {
      "from" : {
        "x" : 2365,
        "y" : 429
      },
      "to" : {
        "x" : 2557,
        "y" : 432
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2550,
        "y" : 436
      },
      "b" : {
        "x" : 2557,
        "y" : 432
      },
      "c" : {
        "x" : 2550,
        "y" : 428
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2550,
        "y" : 428
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2365,
        "y" : 429
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2365,
        "y" : 429
      }
    },
    "inputs" : [ {
      "id" : 21344,
      "points" : [ {
        "x" : 1862,
        "y" : 289
      } ]
    }, {
      "id" : 21346,
      "points" : [ {
        "x" : 1984,
        "y" : 465
      } ]
    } ],
    "outputs" : [ {
      "id" : 21347
    } ]
  }, {
    "id" : 21412,
    "reactomeId" : 10258462,
    "displayName" : "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1066,
      "y" : 151
    },
    "minX" : 926,
    "maxX" : 1126,
    "minY" : 145,
    "maxY" : 221,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 926,
        "y" : 153
      },
      "to" : {
        "x" : 1066,
        "y" : 151
      }
    }, {
      "from" : {
        "x" : 1066,
        "y" : 151
      },
      "to" : {
        "x" : 1126,
        "y" : 221
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1118,
        "y" : 218
      },
      "b" : {
        "x" : 1126,
        "y" : 221
      },
      "c" : {
        "x" : 1125,
        "y" : 213
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1125,
        "y" : 213
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1066,
        "y" : 151
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1066,
        "y" : 151
      }
    },
    "inputs" : [ {
      "id" : 21330,
      "points" : [ {
        "x" : 598,
        "y" : 235
      } ]
    }, {
      "id" : 21411,
      "points" : [ {
        "x" : 903,
        "y" : 235
      } ]
    } ],
    "outputs" : [ {
      "id" : 21413
    } ]
  }, {
    "id" : 21348,
    "reactomeId" : 10265444,
    "displayName" : "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2583,
      "y" : 550
    },
    "minX" : 2577,
    "maxX" : 2589,
    "minY" : 513,
    "maxY" : 579,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2583,
        "y" : 513
      },
      "to" : {
        "x" : 2583,
        "y" : 550
      }
    }, {
      "from" : {
        "x" : 2583,
        "y" : 550
      },
      "to" : {
        "x" : 2583,
        "y" : 579
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2577,
        "y" : 544
      },
      "b" : {
        "x" : 2589,
        "y" : 556
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2583,
        "y" : 550
      }
    },
    "inputs" : [ {
      "id" : 21347,
      "points" : [ {
        "x" : 2602,
        "y" : 475
      } ]
    }, {
      "id" : 21349,
      "points" : [ {
        "x" : 2536,
        "y" : 495
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 21350,
      "points" : [ {
        "x" : 2528,
        "y" : 588
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 21351,
      "points" : [ {
        "x" : 2604,
        "y" : 602
      } ]
    } ],
    "catalysts" : [ {
      "id" : 21347,
      "points" : [ {
        "x" : 2622,
        "y" : 475
      }, {
        "x" : 2623,
        "y" : 520
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 21352,
      "points" : [ {
        "x" : 2110,
        "y" : 274
      }, {
        "x" : 2462,
        "y" : 387
      }, {
        "x" : 2463,
        "y" : 546
      } ]
    } ]
  }, {
    "id" : 21414,
    "reactomeId" : 10258135,
    "displayName" : "IL31:IL31RA:JAK1 binds OSMR:JAK1",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 632,
      "y" : 1398
    },
    "minX" : 461,
    "maxX" : 707,
    "minY" : 1296,
    "maxY" : 1404,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 461,
        "y" : 1398
      },
      "to" : {
        "x" : 632,
        "y" : 1398
      }
    }, {
      "from" : {
        "x" : 632,
        "y" : 1398
      },
      "to" : {
        "x" : 707,
        "y" : 1296
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 706,
        "y" : 1304
      },
      "b" : {
        "x" : 707,
        "y" : 1296
      },
      "c" : {
        "x" : 700,
        "y" : 1299
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 700,
        "y" : 1299
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 626,
        "y" : 1392
      },
      "b" : {
        "x" : 638,
        "y" : 1404
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 632,
        "y" : 1398
      }
    },
    "inputs" : [ {
      "id" : 21415,
      "points" : [ {
        "x" : 279,
        "y" : 1287
      } ]
    }, {
      "id" : 21416,
      "points" : [ {
        "x" : 574,
        "y" : 1287
      } ]
    } ],
    "outputs" : [ {
      "id" : 21417
    } ]
  }, {
    "id" : 21353,
    "reactomeId" : 10265492,
    "displayName" : "SOCS3 binds IL6ST",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1948,
      "y" : 276
    },
    "minX" : 1922,
    "maxX" : 1980,
    "minY" : 268,
    "maxY" : 282,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1922,
        "y" : 276
      },
      "to" : {
        "x" : 1948,
        "y" : 276
      }
    }, {
      "from" : {
        "x" : 1948,
        "y" : 276
      },
      "to" : {
        "x" : 1980,
        "y" : 268
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1974,
        "y" : 274
      },
      "b" : {
        "x" : 1980,
        "y" : 268
      },
      "c" : {
        "x" : 1972,
        "y" : 266
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1972,
        "y" : 266
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1948,
        "y" : 276
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1948,
        "y" : 276
      }
    },
    "inputs" : [ {
      "id" : 21354,
      "points" : [ {
        "x" : 1919,
        "y" : 284
      } ]
    }, {
      "id" : 21344,
      "points" : [ {
        "x" : 1894,
        "y" : 268
      } ]
    } ],
    "outputs" : [ {
      "id" : 21352
    } ]
  }, {
    "id" : 21418,
    "reactomeId" : 10320221,
    "displayName" : "IL6R binds IL6R inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 255,
      "y" : 189
    },
    "minX" : 249,
    "maxX" : 326,
    "minY" : 183,
    "maxY" : 229,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 255,
        "y" : 190
      },
      "to" : {
        "x" : 255,
        "y" : 189
      }
    }, {
      "from" : {
        "x" : 255,
        "y" : 189
      },
      "to" : {
        "x" : 326,
        "y" : 229
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 318,
        "y" : 229
      },
      "b" : {
        "x" : 326,
        "y" : 229
      },
      "c" : {
        "x" : 322,
        "y" : 222
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 322,
        "y" : 222
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 255,
        "y" : 189
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 255,
        "y" : 189
      }
    },
    "inputs" : [ {
      "id" : 21326,
      "points" : [ {
        "x" : 264,
        "y" : 232
      } ]
    }, {
      "id" : 21419,
      "points" : [ {
        "x" : 199,
        "y" : 173
      } ]
    } ],
    "outputs" : [ {
      "id" : 21328
    } ]
  }, {
    "id" : 21355,
    "reactomeId" : 10265490,
    "displayName" : "Serine phosphorylation of STATs",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2599,
      "y" : 740
    },
    "minX" : 2593,
    "maxX" : 2605,
    "minY" : 709,
    "maxY" : 767,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 2599,
        "y" : 709
      },
      "to" : {
        "x" : 2599,
        "y" : 740
      }
    }, {
      "from" : {
        "x" : 2599,
        "y" : 740
      },
      "to" : {
        "x" : 2599,
        "y" : 767
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2593,
        "y" : 734
      },
      "b" : {
        "x" : 2605,
        "y" : 746
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2599,
        "y" : 740
      }
    },
    "inputs" : [ {
      "id" : 21351,
      "points" : [ {
        "x" : 2617,
        "y" : 672
      } ]
    }, {
      "id" : 21356,
      "points" : [ {
        "x" : 2534,
        "y" : 697
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 21357,
      "points" : [ {
        "x" : 2525,
        "y" : 818
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 21358,
      "points" : [ {
        "x" : 2617,
        "y" : 807
      } ]
    } ]
  }, {
    "id" : 21359,
    "reactomeId" : 10265447,
    "displayName" : "Phosphorylated STATs are released",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2377,
      "y" : 635
    },
    "minX" : 1858,
    "maxX" : 2534,
    "minY" : 503,
    "maxY" : 641,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 2534,
        "y" : 636
      },
      "to" : {
        "x" : 2377,
        "y" : 635
      }
    }, {
      "from" : {
        "x" : 2377,
        "y" : 635
      },
      "to" : {
        "x" : 1858,
        "y" : 503
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 2377,
        "y" : 635
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 2377,
        "y" : 635
      }
    },
    "inputs" : [ {
      "id" : 21351
    } ],
    "outputs" : [ {
      "id" : 21360,
      "points" : [ {
        "x" : 2047,
        "y" : 636
      } ]
    }, {
      "id" : 21344,
      "points" : [ {
        "x" : 1832,
        "y" : 289
      } ]
    } ]
  }, {
    "id" : 21361,
    "reactomeId" : 10265417,
    "displayName" : "Phosphorylated STAT1, STAT3 form dimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2081,
      "y" : 752
    },
    "minX" : 2075,
    "maxX" : 2087,
    "minY" : 698,
    "maxY" : 779,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2081,
        "y" : 698
      },
      "to" : {
        "x" : 2081,
        "y" : 752
      }
    }, {
      "from" : {
        "x" : 2081,
        "y" : 752
      },
      "to" : {
        "x" : 2082,
        "y" : 779
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2078,
        "y" : 772
      },
      "b" : {
        "x" : 2082,
        "y" : 779
      },
      "c" : {
        "x" : 2086,
        "y" : 772
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2086,
        "y" : 772
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2075,
        "y" : 746
      },
      "b" : {
        "x" : 2087,
        "y" : 758
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2081,
        "y" : 752
      }
    },
    "inputs" : [ {
      "id" : 21360,
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 21362
    } ]
  }, {
    "id" : 21363,
    "reactomeId" : 10265481,
    "displayName" : "PTPN11 binds p-Y759-IL6ST",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1638,
      "y" : 726
    },
    "minX" : 1605,
    "maxX" : 1651,
    "minY" : 685,
    "maxY" : 838,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1651,
        "y" : 685
      },
      "to" : {
        "x" : 1638,
        "y" : 726
      }
    }, {
      "from" : {
        "x" : 1638,
        "y" : 726
      },
      "to" : {
        "x" : 1605,
        "y" : 838
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1603,
        "y" : 830
      },
      "b" : {
        "x" : 1605,
        "y" : 838
      },
      "c" : {
        "x" : 1611,
        "y" : 832
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1611,
        "y" : 832
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1638,
        "y" : 726
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1638,
        "y" : 726
      }
    },
    "inputs" : [ {
      "id" : 21364,
      "points" : [ {
        "x" : 1691,
        "y" : 668
      } ]
    }, {
      "id" : 21344,
      "points" : [ {
        "x" : 1815,
        "y" : 289
      } ]
    } ],
    "outputs" : [ {
      "id" : 21365
    } ]
  }, {
    "id" : 21366,
    "reactomeId" : 10265479,
    "displayName" : "PTPN11 is phosphorylated",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1721,
      "y" : 845
    },
    "minX" : 1695,
    "maxX" : 1750,
    "minY" : 839,
    "maxY" : 851,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1695,
        "y" : 845
      },
      "to" : {
        "x" : 1721,
        "y" : 845
      }
    }, {
      "from" : {
        "x" : 1721,
        "y" : 845
      },
      "to" : {
        "x" : 1750,
        "y" : 845
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1715,
        "y" : 839
      },
      "b" : {
        "x" : 1727,
        "y" : 851
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1721,
        "y" : 845
      }
    },
    "inputs" : [ {
      "id" : 21367,
      "points" : [ {
        "x" : 1672,
        "y" : 822
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 21365,
      "points" : [ {
        "x" : 1660,
        "y" : 857
      } ]
    } ],
    "outputs" : [ {
      "id" : 21368,
      "points" : [ {
        "x" : 1787,
        "y" : 816
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 21369,
      "points" : [ {
        "x" : 1777,
        "y" : 855
      } ]
    } ],
    "catalysts" : [ {
      "id" : 21365,
      "points" : [ {
        "x" : 1660,
        "y" : 897
      }, {
        "x" : 1720,
        "y" : 916
      } ]
    } ]
  }, {
    "id" : 21370,
    "reactomeId" : 10265476,
    "displayName" : "PTPN11 binds CBL",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1424,
      "y" : 845
    },
    "minX" : 1378,
    "maxX" : 1471,
    "minY" : 839,
    "maxY" : 851,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1471,
        "y" : 845
      },
      "to" : {
        "x" : 1424,
        "y" : 845
      }
    }, {
      "from" : {
        "x" : 1424,
        "y" : 845
      },
      "to" : {
        "x" : 1378,
        "y" : 846
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1385,
        "y" : 842
      },
      "b" : {
        "x" : 1378,
        "y" : 846
      },
      "c" : {
        "x" : 1385,
        "y" : 850
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1385,
        "y" : 850
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1424,
        "y" : 845
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1424,
        "y" : 845
      }
    },
    "inputs" : [ {
      "id" : 21365,
      "points" : [ {
        "x" : 1528,
        "y" : 861
      } ]
    }, {
      "id" : 21371,
      "points" : [ {
        "x" : 1499,
        "y" : 816
      } ]
    } ],
    "outputs" : [ {
      "id" : 21372
    } ]
  }, {
    "id" : 21373,
    "reactomeId" : 10265437,
    "displayName" : "STAT1 and STAT3 dimers translocate to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2084,
      "y" : 913
    },
    "minX" : 2078,
    "maxX" : 2090,
    "minY" : 870,
    "maxY" : 989,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 2084,
        "y" : 870
      },
      "to" : {
        "x" : 2084,
        "y" : 913
      }
    }, {
      "from" : {
        "x" : 2084,
        "y" : 913
      },
      "to" : {
        "x" : 2084,
        "y" : 989
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2080,
        "y" : 982
      },
      "b" : {
        "x" : 2084,
        "y" : 989
      },
      "c" : {
        "x" : 2088,
        "y" : 982
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2088,
        "y" : 982
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2078,
        "y" : 907
      },
      "b" : {
        "x" : 2090,
        "y" : 919
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2084,
        "y" : 913
      }
    },
    "inputs" : [ {
      "id" : 21362
    } ],
    "outputs" : [ {
      "id" : 21374
    } ]
  }, {
    "id" : 21375,
    "reactomeId" : 10298468,
    "displayName" : "CRLF1 binds CLCF1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2414,
      "y" : 216
    },
    "minX" : 2386,
    "maxX" : 2420,
    "minY" : 210,
    "maxY" : 233,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2386,
        "y" : 217
      },
      "to" : {
        "x" : 2414,
        "y" : 216
      }
    }, {
      "from" : {
        "x" : 2414,
        "y" : 216
      },
      "to" : {
        "x" : 2419,
        "y" : 233
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2413,
        "y" : 227
      },
      "b" : {
        "x" : 2419,
        "y" : 233
      },
      "c" : {
        "x" : 2421,
        "y" : 225
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2421,
        "y" : 225
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2414,
        "y" : 216
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2414,
        "y" : 216
      }
    },
    "inputs" : [ {
      "id" : 21376,
      "points" : [ {
        "x" : 2355,
        "y" : 234
      } ]
    }, {
      "id" : 21377,
      "points" : [ {
        "x" : 2362,
        "y" : 208
      } ]
    } ],
    "outputs" : [ {
      "id" : 21378
    } ]
  } ],
  "compartments" : [ {
    "id" : 21420,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2235,
      "y" : 1063
    },
    "minX" : 2002,
    "maxX" : 2468,
    "minY" : 961,
    "maxY" : 1166,
    "prop" : {
      "x" : 2002,
      "y" : 961,
      "width" : 466,
      "height" : 205
    },
    "textPosition" : {
      "x" : 2023,
      "y" : 1107
    },
    "insets" : {
      "x" : 2012,
      "y" : 971,
      "width" : 446,
      "height" : 185
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 21374 ]
  }, {
    "id" : 21421,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1388,
      "y" : 761
    },
    "minX" : 161,
    "maxX" : 2615,
    "minY" : 245,
    "maxY" : 1277,
    "prop" : {
      "x" : 161,
      "y" : 245,
      "width" : 2454,
      "height" : 1032
    },
    "textPosition" : {
      "x" : 624,
      "y" : 1170
    },
    "insets" : {
      "x" : 171,
      "y" : 255,
      "width" : 2434,
      "height" : 1012
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 21386, 21330, 21327, 21331, 21333, 21335, 21336, 21338, 21339, 21340, 21342, 21343, 21344, 21346, 21347, 21349, 21350, 21351, 21352, 21354, 21356, 21357, 21364, 21365, 21367, 21368, 21369, 21371, 21372, 21395, 21326, 21332, 21337, 21341, 21345, 21348, 21353, 21355, 21359, 21363, 21366, 21370, 21422, 21423, 21358, 21380, 21376, 21378, 21379, 21381, 21384, 21382, 21383, 21425, 21385, 21388, 21390, 21393, 21396, 21397, 21399, 21427, 21401, 21428, 21402, 21403, 21404, 21429, 21407, 21430, 21373, 21411, 21413, 21410, 21424, 21405, 21387, 21415, 21416, 21417, 21420, 21360, 21361, 21362, 21389, 21328 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 21425,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1361,
      "y" : 462
    },
    "minX" : 242,
    "maxX" : 2480,
    "minY" : 262,
    "maxY" : 663,
    "segments" : [ {
      "from" : {
        "x" : 2480,
        "y" : 262
      },
      "to" : {
        "x" : 242,
        "y" : 663
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1355,
        "y" : 456
      },
      "b" : {
        "x" : 1367,
        "y" : 468
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1361,
        "y" : 462
      }
    },
    "inputs" : [ {
      "id" : 21381
    } ],
    "outputs" : [ {
      "id" : 21383
    } ]
  }, {
    "id" : 21426,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 97,
      "y" : 625
    },
    "minX" : 91,
    "maxX" : 146,
    "minY" : 458,
    "maxY" : 801,
    "segments" : [ {
      "from" : {
        "x" : 146,
        "y" : 458
      },
      "to" : {
        "x" : 97,
        "y" : 475
      }
    }, {
      "from" : {
        "x" : 97,
        "y" : 475
      },
      "to" : {
        "x" : 97,
        "y" : 775
      }
    }, {
      "from" : {
        "x" : 97,
        "y" : 775
      },
      "to" : {
        "x" : 145,
        "y" : 801
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 91,
        "y" : 619
      },
      "b" : {
        "x" : 103,
        "y" : 631
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 97,
        "y" : 625
      }
    },
    "inputs" : [ {
      "id" : 21393
    } ],
    "outputs" : [ {
      "id" : 21396
    } ]
  }, {
    "id" : 21427,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 325,
      "y" : 629
    },
    "minX" : 201,
    "maxX" : 331,
    "minY" : 392,
    "maxY" : 905,
    "segments" : [ {
      "from" : {
        "x" : 201,
        "y" : 392
      },
      "to" : {
        "x" : 326,
        "y" : 433
      }
    }, {
      "from" : {
        "x" : 326,
        "y" : 433
      },
      "to" : {
        "x" : 324,
        "y" : 825
      }
    }, {
      "from" : {
        "x" : 324,
        "y" : 825
      },
      "to" : {
        "x" : 205,
        "y" : 905
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 319,
        "y" : 623
      },
      "b" : {
        "x" : 331,
        "y" : 635
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 325,
        "y" : 629
      }
    },
    "inputs" : [ {
      "id" : 21388
    } ],
    "outputs" : [ {
      "id" : 21399
    } ]
  }, {
    "id" : 21428,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 296,
      "y" : 906
    },
    "minX" : 190,
    "maxX" : 302,
    "minY" : 849,
    "maxY" : 994,
    "segments" : [ {
      "from" : {
        "x" : 190,
        "y" : 994
      },
      "to" : {
        "x" : 296,
        "y" : 930
      }
    }, {
      "from" : {
        "x" : 296,
        "y" : 930
      },
      "to" : {
        "x" : 296,
        "y" : 883
      }
    }, {
      "from" : {
        "x" : 296,
        "y" : 883
      },
      "to" : {
        "x" : 210,
        "y" : 849
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 290,
        "y" : 900
      },
      "b" : {
        "x" : 302,
        "y" : 912
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 296,
        "y" : 906
      }
    },
    "inputs" : [ {
      "id" : 21401
    } ],
    "outputs" : [ {
      "id" : 21396
    } ]
  }, {
    "id" : 21429,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 273,
      "y" : 1027
    },
    "minX" : 186,
    "maxX" : 279,
    "minY" : 953,
    "maxY" : 1146,
    "segments" : [ {
      "from" : {
        "x" : 186,
        "y" : 1146
      },
      "to" : {
        "x" : 273,
        "y" : 1076
      }
    }, {
      "from" : {
        "x" : 273,
        "y" : 1076
      },
      "to" : {
        "x" : 273,
        "y" : 979
      }
    }, {
      "from" : {
        "x" : 273,
        "y" : 979
      },
      "to" : {
        "x" : 214,
        "y" : 953
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 267,
        "y" : 1021
      },
      "b" : {
        "x" : 279,
        "y" : 1033
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 273,
        "y" : 1027
      }
    },
    "inputs" : [ {
      "id" : 21404
    } ],
    "outputs" : [ {
      "id" : 21399
    } ]
  }, {
    "id" : 21430,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 173,
      "y" : 792
    },
    "minX" : 167,
    "maxX" : 179,
    "minY" : 783,
    "maxY" : 801,
    "segments" : [ {
      "from" : {
        "x" : 174,
        "y" : 783
      },
      "to" : {
        "x" : 172,
        "y" : 801
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 167,
        "y" : 786
      },
      "b" : {
        "x" : 179,
        "y" : 798
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 173,
        "y" : 792
      }
    },
    "inputs" : [ {
      "id" : 21407
    } ],
    "outputs" : [ {
      "id" : 21396
    } ]
  }, {
    "id" : 21422,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 981,
      "y" : 312
    },
    "minX" : 712,
    "maxX" : 1238,
    "minY" : 267,
    "maxY" : 318,
    "segments" : [ {
      "from" : {
        "x" : 712,
        "y" : 267
      },
      "to" : {
        "x" : 820,
        "y" : 313
      }
    }, {
      "from" : {
        "x" : 820,
        "y" : 313
      },
      "to" : {
        "x" : 1143,
        "y" : 312
      }
    }, {
      "from" : {
        "x" : 1143,
        "y" : 312
      },
      "to" : {
        "x" : 1238,
        "y" : 275
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 975,
        "y" : 306
      },
      "b" : {
        "x" : 987,
        "y" : 318
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 981,
        "y" : 312
      }
    },
    "inputs" : [ {
      "id" : 21333
    } ],
    "outputs" : [ {
      "id" : 21335
    } ]
  }, {
    "id" : 21423,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 983,
      "y" : 294
    },
    "minX" : 807,
    "maxX" : 1218,
    "minY" : 272,
    "maxY" : 300,
    "segments" : [ {
      "from" : {
        "x" : 807,
        "y" : 272
      },
      "to" : {
        "x" : 832,
        "y" : 295
      }
    }, {
      "from" : {
        "x" : 832,
        "y" : 295
      },
      "to" : {
        "x" : 1135,
        "y" : 294
      }
    }, {
      "from" : {
        "x" : 1135,
        "y" : 294
      },
      "to" : {
        "x" : 1218,
        "y" : 275
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 977,
        "y" : 288
      },
      "b" : {
        "x" : 989,
        "y" : 300
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 983,
        "y" : 294
      }
    },
    "inputs" : [ {
      "id" : 21331
    } ],
    "outputs" : [ {
      "id" : 21335
    } ]
  } ],
  "shadows" : [ {
    "id" : 21431,
    "reactomeId" : 10330431,
    "displayName" : "IL-6-type cytokine receptor ligand interactions",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1303,
      "y" : 774
    },
    "minX" : -10,
    "maxX" : 2616,
    "minY" : 135,
    "maxY" : 1414,
    "prop" : {
      "x" : -10,
      "y" : 1055,
      "width" : 2626,
      "height" : 359
    },
    "points" : [ {
      "x" : -10,
      "y" : 135
    }, {
      "x" : 2616,
      "y" : 135
    }, {
      "x" : 2616,
      "y" : 1414
    }, {
      "x" : -10,
      "y" : 1414
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 21432,
    "reactomeId" : 10330627,
    "displayName" : "Interleukin-6 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1427,
      "y" : 525
    },
    "minX" : 118,
    "maxX" : 2737,
    "minY" : -4,
    "maxY" : 1055,
    "prop" : {
      "x" : 118,
      "y" : -4,
      "width" : 2619,
      "height" : 139
    },
    "points" : [ {
      "x" : 118,
      "y" : -4
    }, {
      "x" : 2737,
      "y" : -4
    }, {
      "x" : 2737,
      "y" : 1055
    }, {
      "x" : 118,
      "y" : 1055
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 2733,
  "minY" : 0,
  "maxY" : 1404,
  "disease" : false
}