{ "dbId" : 10330419, "stableId" : "R-CFA-447115", "displayName" : "Interleukin-12 family signaling", "nodes" : [ { "id" : 86785, "reactomeId" : 10315612, "displayName" : "IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3268, "y" : 1088 }, "minX" : 3202, "maxX" : 3340, "minY" : 1052, "maxY" : 1140, "prop" : { "x" : 3202, "y" : 1058, "width" : 132, "height" : 61 }, "textPosition" : { "x" : 3204, "y" : 1070 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3334, "y" : 1058 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3334, "y" : 1058 } } }, "connectors" : [ { "edgeId" : 86786, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86782, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3300, "y" : 1122 }, "to" : { "x" : 3324, "y" : 1140 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3308, "y" : 1123 }, "b" : { "x" : 3300, "y" : 1122 }, "c" : { "x" : 3303, "y" : 1129 }, "type" : "ARROW", "centre" : { "x" : 3303, "y" : 1129 } } } ] }, { "id" : 86784, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3295, "y" : 1187 }, "minX" : 3276, "maxX" : 3324, "minY" : 1140, "maxY" : 1202, "prop" : { "x" : 3276, "y" : 1172, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 3279, "y" : 1176 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3310, "y" : 1177 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3310, "y" : 1177 } } }, "connectors" : [ { "edgeId" : 86782, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3304, "y" : 1169 }, "to" : { "x" : 3324, "y" : 1140 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3308, "y" : 1148 }, "b" : { "x" : 3320, "y" : 1160 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3314, "y" : 1154 } } }, "endShape" : { "a" : { "x" : 3305, "y" : 1161 }, "b" : { "x" : 3304, "y" : 1169 }, "c" : { "x" : 3311, "y" : 1166 }, "type" : "ARROW", "centre" : { "x" : 3311, "y" : 1166 } } } ] }, { "id" : 86787, "reactomeId" : 10315444, "displayName" : "phospho-STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3613, "y" : 1455 }, "minX" : 3508, "maxX" : 3657, "minY" : 1341, "maxY" : 1466, "prop" : { "x" : 3575, "y" : 1445, "width" : 76, "height" : 21 }, "textPosition" : { "x" : 3579, "y" : 1438 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3651, "y" : 1445 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3651, "y" : 1445 } } }, "connectors" : [ { "edgeId" : 86786, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3603, "y" : 1442 }, "to" : { "x" : 3508, "y" : 1341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3595, "y" : 1440 }, "b" : { "x" : 3603, "y" : 1442 }, "c" : { "x" : 3601, "y" : 1434 }, "type" : "ARROW", "centre" : { "x" : 3601, "y" : 1434 } } } ] }, { "id" : 86789, "reactomeId" : 10313283, "displayName" : "STAT4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 4848, "y" : 1303 }, "minX" : 4820, "maxX" : 4885, "minY" : 1228, "maxY" : 1314, "prop" : { "x" : 4820, "y" : 1292, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 4825, "y" : 1292 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4876, "y" : 1292 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4876, "y" : 1292 } } }, "connectors" : [ { "edgeId" : 86788, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4853, "y" : 1289 }, "to" : { "x" : 4885, "y" : 1228 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86793, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 6258, "y" : 1177 }, "minX" : 6239, "maxX" : 6282, "minY" : 1139, "maxY" : 1192, "prop" : { "x" : 6239, "y" : 1162, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 6242, "y" : 1166 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6272, "y" : 1167 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6272, "y" : 1167 } } }, "connectors" : [ { "edgeId" : 86792, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6267, "y" : 1159 }, "to" : { "x" : 6282, "y" : 1139 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 6268, "y" : 1143 }, "b" : { "x" : 6280, "y" : 1155 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6274, "y" : 1149 } } } } ] }, { "id" : 86794, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 6381, "y" : 1173 }, "minX" : 6346, "maxX" : 6402, "minY" : 1139, "maxY" : 1188, "prop" : { "x" : 6362, "y" : 1158, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 6365, "y" : 1162 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6396, "y" : 1163 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6396, "y" : 1163 } } }, "connectors" : [ { "edgeId" : 86792, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6365, "y" : 1155 }, "to" : { "x" : 6346, "y" : 1139 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 6349, "y" : 1141 }, "b" : { "x" : 6361, "y" : 1153 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6355, "y" : 1147 } } }, "endShape" : { "a" : { "x" : 6357, "y" : 1154 }, "b" : { "x" : 6365, "y" : 1155 }, "c" : { "x" : 6362, "y" : 1147 }, "type" : "ARROW", "centre" : { "x" : 6362, "y" : 1147 } } } ] }, { "id" : 86797, "reactomeId" : 10258049, "displayName" : "IL27", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 5877, "y" : 867 }, "minX" : 5849, "maxX" : 5911, "minY" : 850, "maxY" : 951, "prop" : { "x" : 5849, "y" : 856, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 5860, "y" : 856 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5905, "y" : 856 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5905, "y" : 856 } } }, "connectors" : [ { "edgeId" : 86796, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 5876, "y" : 881 }, "to" : { "x" : 5872, "y" : 951 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 5868, "y" : 951 }, "b" : { "x" : 5876, "y" : 951 }, "c" : { "x" : 5872, "y" : 951 }, "type" : "STOP", "centre" : { "x" : 5872, "y" : 951 } } } ] }, { "id" : 86799, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1738, "y" : 1181 }, "minX" : 1719, "maxX" : 1769, "minY" : 1138, "maxY" : 1196, "prop" : { "x" : 1719, "y" : 1166, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 1722, "y" : 1170 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1752, "y" : 1171 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1752, "y" : 1171 } } }, "connectors" : [ { "edgeId" : 86798, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1748, "y" : 1163 }, "to" : { "x" : 1769, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86800, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1849, "y" : 1178 }, "minX" : 1830, "maxX" : 1870, "minY" : 1139, "maxY" : 1193, "prop" : { "x" : 1830, "y" : 1163, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1833, "y" : 1167 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1864, "y" : 1168 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1864, "y" : 1168 } } }, "connectors" : [ { "edgeId" : 86798, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1842, "y" : 1160 }, "to" : { "x" : 1832, "y" : 1139 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1835, "y" : 1155 }, "b" : { "x" : 1842, "y" : 1160 }, "c" : { "x" : 1843, "y" : 1152 }, "type" : "ARROW", "centre" : { "x" : 1843, "y" : 1152 } } } ] }, { "id" : 86617, "reactomeId" : 10258019, "displayName" : "IL12A:IL12B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1371, "y" : 901 }, "minX" : 1334, "maxX" : 1442, "minY" : 877, "maxY" : 995, "prop" : { "x" : 1334, "y" : 883, "width" : 74, "height" : 37 }, "textPosition" : { "x" : 1348, "y" : 885 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1408, "y" : 883 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1408, "y" : 883 } } }, "connectors" : [ { "edgeId" : 86795, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1379, "y" : 923 }, "to" : { "x" : 1415, "y" : 995 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1386, "y" : 927 }, "b" : { "x" : 1379, "y" : 923 }, "c" : { "x" : 1379, "y" : 931 }, "type" : "ARROW", "centre" : { "x" : 1379, "y" : 931 } } }, { "edgeId" : 86616, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1389, "y" : 923 }, "to" : { "x" : 1442, "y" : 972 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86646, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86619, "reactomeId" : 10258029, "displayName" : "IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1524, "y" : 1087 }, "minX" : 1461, "maxX" : 1617, "minY" : 1056, "maxY" : 1134, "prop" : { "x" : 1461, "y" : 1062, "width" : 126, "height" : 50 }, "textPosition" : { "x" : 1475, "y" : 1063 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1587, "y" : 1062 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1587, "y" : 1062 } } }, "connectors" : [ { "edgeId" : 86795, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86677, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1556, "y" : 1115 }, "to" : { "x" : 1586, "y" : 1134 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86677, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1590, "y" : 1091 }, "to" : { "x" : 1610, "y" : 1093 } }, { "from" : { "x" : 1610, "y" : 1093 }, "to" : { "x" : 1612, "y" : 1117 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1613, "y" : 1121 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1613, "y" : 1121 } } }, { "edgeId" : 86741, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86616, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86618, "reactomeId" : 10258027, "displayName" : "IL12RB1:TYK2:IL12RB2:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1397, "y" : 1089 }, "minX" : 1352, "maxX" : 1448, "minY" : 972, "maxY" : 1113, "prop" : { "x" : 1352, "y" : 1065, "width" : 90, "height" : 48 }, "textPosition" : { "x" : 1353, "y" : 1064 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1442, "y" : 1065 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1442, "y" : 1065 } } }, "connectors" : [ { "edgeId" : 86661, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86795, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1401, "y" : 1062 }, "to" : { "x" : 1415, "y" : 995 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1399, "y" : 1054 }, "b" : { "x" : 1401, "y" : 1062 }, "c" : { "x" : 1406, "y" : 1056 }, "type" : "ARROW", "centre" : { "x" : 1406, "y" : 1056 } } }, { "edgeId" : 86616, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1406, "y" : 1062 }, "to" : { "x" : 1442, "y" : 972 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86621, "reactomeId" : 10257991, "displayName" : "IL12B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1639, "y" : 854 }, "minX" : 1507, "maxX" : 1669, "minY" : 837, "maxY" : 970, "prop" : { "x" : 1615, "y" : 843, "width" : 48, "height" : 22 }, "textPosition" : { "x" : 1618, "y" : 843 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1663, "y" : 843 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1663, "y" : 843 } } }, "connectors" : [ { "edgeId" : 86616, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1626, "y" : 868 }, "to" : { "x" : 1510, "y" : 967 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1507, "y" : 964 }, "b" : { "x" : 1513, "y" : 970 }, "c" : { "x" : 1510, "y" : 967 }, "type" : "STOP", "centre" : { "x" : 1510, "y" : 967 } } }, { "edgeId" : 86650, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86620, "reactomeId" : 10258031, "displayName" : "2xIL12B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1565, "y" : 857 }, "minX" : 1503, "maxX" : 1602, "minY" : 840, "maxY" : 967, "prop" : { "x" : 1534, "y" : 846, "width" : 62, "height" : 22 }, "textPosition" : { "x" : 1537, "y" : 847 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1596, "y" : 846 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1596, "y" : 846 } } }, "connectors" : [ { "edgeId" : 86662, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86616, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1559, "y" : 871 }, "to" : { "x" : 1507, "y" : 965 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1503, "y" : 963 }, "b" : { "x" : 1511, "y" : 967 }, "c" : { "x" : 1507, "y" : 965 }, "type" : "STOP", "centre" : { "x" : 1507, "y" : 965 } } } ] }, { "id" : 86623, "reactomeId" : 10258101, "displayName" : "IL12A:EBI3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3489, "y" : 347 }, "minX" : 3444, "maxX" : 3532, "minY" : 311, "maxY" : 358, "prop" : { "x" : 3452, "y" : 336, "width" : 74, "height" : 22 }, "textPosition" : { "x" : 3453, "y" : 337 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3526, "y" : 336 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3526, "y" : 336 } } }, "connectors" : [ { "edgeId" : 86732, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3475, "y" : 333 }, "to" : { "x" : 3444, "y" : 311 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3467, "y" : 332 }, "b" : { "x" : 3475, "y" : 333 }, "c" : { "x" : 3472, "y" : 326 }, "type" : "ARROW", "centre" : { "x" : 3472, "y" : 326 } } }, { "edgeId" : 86622, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86624, "reactomeId" : 10258103, "displayName" : "IL35", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2486, "y" : 815 }, "minX" : 2457, "maxX" : 4348, "minY" : 738, "maxY" : 1024, "prop" : { "x" : 2457, "y" : 803, "width" : 58, "height" : 25 }, "textPosition" : { "x" : 2469, "y" : 807 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2515, "y" : 803 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2515, "y" : 803 } } }, "connectors" : [ { "edgeId" : 86742, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2491, "y" : 831 }, "to" : { "x" : 2577, "y" : 1024 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86744, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2518, "y" : 816 }, "to" : { "x" : 4348, "y" : 914 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86622, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86631, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2518, "y" : 813 }, "to" : { "x" : 4123, "y" : 738 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86773, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2518, "y" : 818 }, "to" : { "x" : 3603, "y" : 941 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86627, "reactomeId" : 10258053, "displayName" : "IL27:EBI3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 5459, "y" : 935 }, "minX" : 5421, "maxX" : 5672, "minY" : 917, "maxY" : 991, "prop" : { "x" : 5421, "y" : 923, "width" : 76, "height" : 24 }, "textPosition" : { "x" : 5427, "y" : 926 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5497, "y" : 923 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5497, "y" : 923 } } }, "connectors" : [ { "edgeId" : 86796, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 5500, "y" : 939 }, "to" : { "x" : 5670, "y" : 960 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 5507, "y" : 936 }, "b" : { "x" : 5500, "y" : 939 }, "c" : { "x" : 5506, "y" : 944 }, "type" : "ARROW", "centre" : { "x" : 5506, "y" : 944 } } }, { "edgeId" : 86625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5500, "y" : 944 }, "to" : { "x" : 5672, "y" : 991 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86634, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86626, "reactomeId" : 10258069, "displayName" : "IL27RA:JAK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 5534, "y" : 1096 }, "minX" : 3603, "maxX" : 5672, "minY" : 941, "maxY" : 1109, "prop" : { "x" : 5489, "y" : 1083, "width" : 91, "height" : 26 }, "textPosition" : { "x" : 5495, "y" : 1088 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5580, "y" : 1083 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5580, "y" : 1083 } } }, "connectors" : [ { "edgeId" : 86796, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 5547, "y" : 1080 }, "to" : { "x" : 5670, "y" : 960 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 5549, "y" : 1072 }, "b" : { "x" : 5547, "y" : 1080 }, "c" : { "x" : 5555, "y" : 1078 }, "type" : "ARROW", "centre" : { "x" : 5555, "y" : 1078 } } }, { "edgeId" : 86625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5551, "y" : 1080 }, "to" : { "x" : 5672, "y" : 991 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86773, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5503, "y" : 1080 }, "to" : { "x" : 5225, "y" : 963 } }, { "from" : { "x" : 5225, "y" : 963 }, "to" : { "x" : 3603, "y" : 941 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86629, "reactomeId" : 10258071, "displayName" : "IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 5963, "y" : 1092 }, "minX" : 5911, "maxX" : 6094, "minY" : 1054, "maxY" : 1135, "prop" : { "x" : 5911, "y" : 1060, "width" : 104, "height" : 64 }, "textPosition" : { "x" : 5911, "y" : 1061 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6015, "y" : 1060 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6015, "y" : 1060 } } }, "connectors" : [ { "edgeId" : 86796, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86686, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6018, "y" : 1114 }, "to" : { "x" : 6061, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86686, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 6018, "y" : 1093 }, "to" : { "x" : 6088, "y" : 1096 } }, { "from" : { "x" : 6088, "y" : 1096 }, "to" : { "x" : 6090, "y" : 1119 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 6090, "y" : 1123 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6090, "y" : 1123 } } }, { "edgeId" : 86625, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86628, "reactomeId" : 10258063, "displayName" : "IL6ST:JAK1, JAK2, (TYK2)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 5356, "y" : 1090 }, "minX" : 4123, "maxX" : 5672, "minY" : 738, "maxY" : 1108, "prop" : { "x" : 5301, "y" : 1072, "width" : 110, "height" : 36 }, "textPosition" : { "x" : 5300, "y" : 1073 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5411, "y" : 1072 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5411, "y" : 1072 } } }, "connectors" : [ { "edgeId" : 86796, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 5399, "y" : 1069 }, "to" : { "x" : 5670, "y" : 960 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 5404, "y" : 1063 }, "b" : { "x" : 5399, "y" : 1069 }, "c" : { "x" : 5407, "y" : 1070 }, "type" : "ARROW", "centre" : { "x" : 5407, "y" : 1070 } } }, { "edgeId" : 86744, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5320, "y" : 1069 }, "to" : { "x" : 5031, "y" : 924 } }, { "from" : { "x" : 5031, "y" : 924 }, "to" : { "x" : 4348, "y" : 914 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 5169, "y" : 990 }, "b" : { "x" : 5181, "y" : 1002 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 5175, "y" : 996 } } } }, { "edgeId" : 86625, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5414, "y" : 1072 }, "to" : { "x" : 5672, "y" : 991 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86631, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5298, "y" : 1074 }, "to" : { "x" : 4123, "y" : 738 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86630, "reactomeId" : 10258073, "displayName" : "IL27RA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 5792, "y" : 1025 }, "minX" : 5762, "maxX" : 5838, "minY" : 992, "maxY" : 1036, "prop" : { "x" : 5762, "y" : 1014, "width" : 60, "height" : 22 }, "textPosition" : { "x" : 5767, "y" : 1014 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5822, "y" : 1014 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5822, "y" : 1014 } } }, "connectors" : [ { "edgeId" : 86625, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 5808, "y" : 1011 }, "to" : { "x" : 5836, "y" : 995 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 5834, "y" : 992 }, "b" : { "x" : 5838, "y" : 998 }, "c" : { "x" : 5836, "y" : 995 }, "type" : "STOP", "centre" : { "x" : 5836, "y" : 995 } } } ] }, { "id" : 86633, "reactomeId" : 10304839, "displayName" : "IL35:IL6ST:JAK1:IL12RB2:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4679, "y" : 1099 }, "minX" : 4630, "maxX" : 4760, "minY" : 1069, "maxY" : 1151, "prop" : { "x" : 4630, "y" : 1075, "width" : 99, "height" : 48 }, "textPosition" : { "x" : 4634, "y" : 1074 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4729, "y" : 1075 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4729, "y" : 1075 } } }, "connectors" : [ { "edgeId" : 86709, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4693, "y" : 1126 }, "to" : { "x" : 4710, "y" : 1151 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86709, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 4732, "y" : 1107 }, "to" : { "x" : 4754, "y" : 1112 } }, { "from" : { "x" : 4754, "y" : 1112 }, "to" : { "x" : 4756, "y" : 1136 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 4756, "y" : 1140 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4756, "y" : 1140 } } }, { "edgeId" : 86631, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86632, "reactomeId" : 10258025, "displayName" : "IL12RB2:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2497, "y" : 1092 }, "minX" : 1292, "maxX" : 4123, "minY" : 738, "maxY" : 1111, "prop" : { "x" : 2455, "y" : 1074, "width" : 85, "height" : 37 }, "textPosition" : { "x" : 2467, "y" : 1076 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2540, "y" : 1074 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2540, "y" : 1074 } } }, "connectors" : [ { "edgeId" : 86661, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2478, "y" : 1071 }, "to" : { "x" : 2420, "y" : 1015 } }, { "from" : { "x" : 2420, "y" : 1015 }, "to" : { "x" : 1292, "y" : 1022 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86742, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2518, "y" : 1071 }, "to" : { "x" : 2577, "y" : 1024 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2541, "y" : 1041 }, "b" : { "x" : 2553, "y" : 1053 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2547, "y" : 1047 } } } }, { "edgeId" : 86631, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2543, "y" : 1082 }, "to" : { "x" : 4123, "y" : 738 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86773, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2543, "y" : 1086 }, "to" : { "x" : 3603, "y" : 941 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86635, "reactomeId" : 10258047, "displayName" : "IL27:EBI3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3575, "y" : 346 }, "minX" : 3543, "maxX" : 3614, "minY" : 304, "maxY" : 357, "prop" : { "x" : 3543, "y" : 335, "width" : 65, "height" : 22 }, "textPosition" : { "x" : 3543, "y" : 336 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3608, "y" : 335 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3608, "y" : 335 } } }, "connectors" : [ { "edgeId" : 86733, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3574, "y" : 332 }, "to" : { "x" : 3572, "y" : 304 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3570, "y" : 325 }, "b" : { "x" : 3574, "y" : 332 }, "c" : { "x" : 3577, "y" : 325 }, "type" : "ARROW", "centre" : { "x" : 3577, "y" : 325 } } }, { "edgeId" : 86634, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86637, "reactomeId" : 10257993, "displayName" : "IL12B:IL23A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 233, "y" : 931 }, "minX" : 196, "maxX" : 276, "minY" : 908, "maxY" : 996, "prop" : { "x" : 196, "y" : 914, "width" : 74, "height" : 35 }, "textPosition" : { "x" : 210, "y" : 914 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 270, "y" : 914 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 270, "y" : 914 } } }, "connectors" : [ { "edgeId" : 86636, "type" : "INPUT", "segments" : [ { "from" : { "x" : 233, "y" : 952 }, "to" : { "x" : 233, "y" : 996 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86649, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86639, "reactomeId" : 10258001, "displayName" : "IL12RB1:TYK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1285, "y" : 1088 }, "minX" : 233, "maxX" : 1334, "minY" : 992, "maxY" : 1105, "prop" : { "x" : 1242, "y" : 1071, "width" : 86, "height" : 34 }, "textPosition" : { "x" : 1254, "y" : 1070 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1328, "y" : 1071 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1328, "y" : 1071 } } }, "connectors" : [ { "edgeId" : 86661, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1286, "y" : 1068 }, "to" : { "x" : 1292, "y" : 1022 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86636, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1266, "y" : 1068 }, "to" : { "x" : 1180, "y" : 992 } }, { "from" : { "x" : 1180, "y" : 992 }, "to" : { "x" : 233, "y" : 996 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86638, "reactomeId" : 10258009, "displayName" : "IL23R:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 123, "y" : 1093 }, "minX" : 89, "maxX" : 233, "minY" : 996, "maxY" : 1112, "prop" : { "x" : 89, "y" : 1074, "width" : 68, "height" : 38 }, "textPosition" : { "x" : 100, "y" : 1077 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 157, "y" : 1074 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 157, "y" : 1074 } } }, "connectors" : [ { "edgeId" : 86636, "type" : "INPUT", "segments" : [ { "from" : { "x" : 144, "y" : 1071 }, "to" : { "x" : 233, "y" : 996 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86640, "reactomeId" : 10258011, "displayName" : "IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 229, "y" : 1084 }, "minX" : 172, "maxX" : 293, "minY" : 1052, "maxY" : 1110, "prop" : { "x" : 172, "y" : 1058, "width" : 115, "height" : 52 }, "textPosition" : { "x" : 184, "y" : 1061 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 287, "y" : 1058 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 287, "y" : 1058 } } }, "connectors" : [ { "edgeId" : 86636, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86643, "reactomeId" : 10313274, "displayName" : "IL23A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 181, "y" : 105 }, "minX" : 156, "maxX" : 226, "minY" : 88, "maxY" : 144, "prop" : { "x" : 156, "y" : 94, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 161, "y" : 94 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 207, "y" : 94 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 207, "y" : 94 } } }, "connectors" : [ { "edgeId" : 86641, "type" : "INPUT", "segments" : [ { "from" : { "x" : 193, "y" : 119 }, "to" : { "x" : 226, "y" : 144 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86642, "reactomeId" : 10313248, "displayName" : "IL12B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 882, "y" : 92 }, "minX" : 226, "maxX" : 1359, "minY" : 75, "maxY" : 182, "prop" : { "x" : 860, "y" : 81, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 861, "y" : 82 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 904, "y" : 81 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 904, "y" : 81 } } }, "connectors" : [ { "edgeId" : 86663, "type" : "INPUT", "segments" : [ { "from" : { "x" : 907, "y" : 95 }, "to" : { "x" : 1359, "y" : 160 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86641, "type" : "INPUT", "segments" : [ { "from" : { "x" : 857, "y" : 93 }, "to" : { "x" : 226, "y" : 144 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86652, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 873, "y" : 170 }, "b" : { "x" : 885, "y" : 182 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 879, "y" : 176 } } } } ] }, { "id" : 86645, "reactomeId" : 10240080, "displayName" : "P4HB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 567, "y" : 201 }, "minX" : 234, "maxX" : 1351, "minY" : 184, "maxY" : 247, "prop" : { "x" : 543, "y" : 190, "width" : 48, "height" : 22 }, "textPosition" : { "x" : 546, "y" : 190 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 591, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 591, "y" : 190 } } }, "connectors" : [ { "edgeId" : 86663, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 594, "y" : 200 }, "to" : { "x" : 1343, "y" : 194 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1347, "y" : 194 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1347, "y" : 194 } } }, { "edgeId" : 86641, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 540, "y" : 200 }, "to" : { "x" : 242, "y" : 189 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 238, "y" : 188 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 238, "y" : 188 } } }, { "edgeId" : 86652, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 594, "y" : 204 }, "to" : { "x" : 862, "y" : 243 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 866, "y" : 243 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 866, "y" : 243 } } } ] }, { "id" : 86644, "reactomeId" : 10313276, "displayName" : "IL12B:IL23A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 226, "y" : 266 }, "minX" : 190, "maxX" : 269, "minY" : 243, "maxY" : 284, "prop" : { "x" : 190, "y" : 249, "width" : 73, "height" : 35 }, "textPosition" : { "x" : 204, "y" : 249 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 263, "y" : 249 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 263, "y" : 249 } } }, "connectors" : [ { "edgeId" : 86641, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86649, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86647, "reactomeId" : 10313343, "displayName" : "IL12A:IL12B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1362, "y" : 510 }, "minX" : 1325, "maxX" : 1405, "minY" : 488, "maxY" : 527, "prop" : { "x" : 1325, "y" : 494, "width" : 74, "height" : 33 }, "textPosition" : { "x" : 1339, "y" : 492 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1399, "y" : 494 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1399, "y" : 494 } } }, "connectors" : [ { "edgeId" : 86646, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86648, "reactomeId" : 10313345, "displayName" : "VAMP7", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1465, "y" : 470 }, "minX" : 1368, "maxX" : 1500, "minY" : 453, "maxY" : 586, "prop" : { "x" : 1437, "y" : 459, "width" : 57, "height" : 23 }, "textPosition" : { "x" : 1440, "y" : 460 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1494, "y" : 459 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1494, "y" : 459 } } }, "connectors" : [ { "edgeId" : 86646, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1454, "y" : 485 }, "to" : { "x" : 1368, "y" : 575 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1370, "y" : 567 }, "b" : { "x" : 1368, "y" : 575 }, "c" : { "x" : 1376, "y" : 573 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1376, "y" : 573 } } }, { "edgeId" : 86646, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1461, "y" : 485 }, "to" : { "x" : 1429, "y" : 582 } }, { "from" : { "x" : 1429, "y" : 582 }, "to" : { "x" : 1371, "y" : 582 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1371, "y" : 586 }, "b" : { "x" : 1371, "y" : 578 }, "c" : { "x" : 1371, "y" : 582 }, "type" : "STOP", "centre" : { "x" : 1371, "y" : 582 } } } ] }, { "id" : 86651, "reactomeId" : 10313257, "displayName" : "IL12B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1629, "y" : 520 }, "minX" : 1604, "maxX" : 1660, "minY" : 503, "maxY" : 531, "prop" : { "x" : 1604, "y" : 509, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 1608, "y" : 509 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1654, "y" : 509 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1654, "y" : 509 } } }, "connectors" : [ { "edgeId" : 86650, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86653, "reactomeId" : 10313368, "displayName" : "2xIL12B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 879, "y" : 340 }, "minX" : 848, "maxX" : 917, "minY" : 323, "maxY" : 351, "prop" : { "x" : 848, "y" : 329, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 852, "y" : 330 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 911, "y" : 329 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 911, "y" : 329 } } }, "connectors" : [ { "edgeId" : 86662, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86652, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86655, "reactomeId" : 10258099, "displayName" : "IL12A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1450, "y" : 84 }, "minX" : 1359, "maxX" : 3321, "minY" : 68, "maxY" : 161, "prop" : { "x" : 1424, "y" : 74, "width" : 52, "height" : 21 }, "textPosition" : { "x" : 1429, "y" : 74 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1476, "y" : 74 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1476, "y" : 74 } } }, "connectors" : [ { "edgeId" : 86663, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1437, "y" : 98 }, "to" : { "x" : 1359, "y" : 160 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86654, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1479, "y" : 85 }, "to" : { "x" : 3321, "y" : 161 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86657, "reactomeId" : 10313351, "displayName" : "CANX:EBI3:IL12A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3321, "y" : 235 }, "minX" : 3269, "maxX" : 3380, "minY" : 207, "maxY" : 257, "prop" : { "x" : 3269, "y" : 213, "width" : 105, "height" : 44 }, "textPosition" : { "x" : 3284, "y" : 222 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3374, "y" : 213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3374, "y" : 213 } } }, "connectors" : [ { "edgeId" : 86732, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86654, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86656, "reactomeId" : 10313333, "displayName" : "CANX:EBI3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3525, "y" : 100 }, "minX" : 3321, "maxX" : 3676, "minY" : 76, "maxY" : 161, "prop" : { "x" : 3492, "y" : 82, "width" : 66, "height" : 36 }, "textPosition" : { "x" : 3503, "y" : 83 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3558, "y" : 82 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3558, "y" : 82 } } }, "connectors" : [ { "edgeId" : 86658, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3561, "y" : 111 }, "to" : { "x" : 3676, "y" : 152 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86665, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86654, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3489, "y" : 109 }, "to" : { "x" : 3321, "y" : 161 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86659, "reactomeId" : 10258041, "displayName" : "IL27", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3740, "y" : 116 }, "minX" : 3676, "maxX" : 3765, "minY" : 99, "maxY" : 152, "prop" : { "x" : 3721, "y" : 105, "width" : 38, "height" : 23 }, "textPosition" : { "x" : 3723, "y" : 106 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3759, "y" : 105 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3759, "y" : 105 } } }, "connectors" : [ { "edgeId" : 86658, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3718, "y" : 126 }, "to" : { "x" : 3676, "y" : 152 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86660, "reactomeId" : 10313335, "displayName" : "CANX:EBI3:IL27", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3674, "y" : 240 }, "minX" : 3626, "maxX" : 3728, "minY" : 216, "maxY" : 259, "prop" : { "x" : 3626, "y" : 222, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 3636, "y" : 224 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3722, "y" : 222 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3722, "y" : 222 } } }, "connectors" : [ { "edgeId" : 86658, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86733, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86664, "reactomeId" : 10313250, "displayName" : "IL12A:IL12B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1361, "y" : 246 }, "minX" : 1321, "maxX" : 1408, "minY" : 229, "maxY" : 257, "prop" : { "x" : 1321, "y" : 235, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 1322, "y" : 236 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1402, "y" : 235 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1402, "y" : 235 } } }, "connectors" : [ { "edgeId" : 86663, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86667, "reactomeId" : 10260028, "displayName" : "CANX", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3486, "y" : 238 }, "minX" : 3444, "maxX" : 3572, "minY" : 214, "maxY" : 311, "prop" : { "x" : 3466, "y" : 227, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 3466, "y" : 227 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3507, "y" : 227 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3507, "y" : 227 } } }, "connectors" : [ { "edgeId" : 86665, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3502, "y" : 224 }, "to" : { "x" : 3523, "y" : 214 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86733, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3500, "y" : 252 }, "to" : { "x" : 3572, "y" : 304 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3508, "y" : 253 }, "b" : { "x" : 3500, "y" : 252 }, "c" : { "x" : 3503, "y" : 259 }, "type" : "ARROW", "centre" : { "x" : 3503, "y" : 259 } } }, { "edgeId" : 86732, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3479, "y" : 252 }, "to" : { "x" : 3444, "y" : 311 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3479, "y" : 260 }, "b" : { "x" : 3479, "y" : 252 }, "c" : { "x" : 3472, "y" : 256 }, "type" : "ARROW", "centre" : { "x" : 3472, "y" : 256 } } } ] }, { "id" : 86666, "reactomeId" : 10258045, "displayName" : "EBI3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3558, "y" : 240 }, "minX" : 3523, "maxX" : 3583, "minY" : 214, "maxY" : 251, "prop" : { "x" : 3540, "y" : 229, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 3541, "y" : 229 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3577, "y" : 229 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3577, "y" : 229 } } }, "connectors" : [ { "edgeId" : 86665, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3543, "y" : 226 }, "to" : { "x" : 3523, "y" : 214 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86669, "reactomeId" : 10258067, "displayName" : "IL27RA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 5629, "y" : 1098 }, "minX" : 5603, "maxX" : 5683, "minY" : 1081, "maxY" : 1109, "prop" : { "x" : 5603, "y" : 1087, "width" : 52, "height" : 22 }, "textPosition" : { "x" : 5604, "y" : 1087 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5655, "y" : 1087 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5655, "y" : 1087 } } }, "connectors" : [ { "edgeId" : 86668, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 5671, "y" : 1092 }, "b" : { "x" : 5683, "y" : 1104 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 5677, "y" : 1098 } } } } ] }, { "id" : 86670, "reactomeId" : 10313458, "displayName" : "2xIL27RA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 5765, "y" : 1096 }, "minX" : 5726, "maxX" : 5810, "minY" : 1079, "maxY" : 1108, "prop" : { "x" : 5726, "y" : 1085, "width" : 78, "height" : 23 }, "textPosition" : { "x" : 5733, "y" : 1087 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5804, "y" : 1085 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5804, "y" : 1085 } } }, "connectors" : [ { "edgeId" : 86668, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86673, "reactomeId" : 10313422, "displayName" : "IL27", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 5877, "y" : 374 }, "minX" : 5857, "maxX" : 5918, "minY" : 339, "maxY" : 385, "prop" : { "x" : 5857, "y" : 363, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 5861, "y" : 363 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5898, "y" : 363 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5898, "y" : 363 } } }, "connectors" : [ { "edgeId" : 86671, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5889, "y" : 360 }, "to" : { "x" : 5918, "y" : 339 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86672, "reactomeId" : 10313420, "displayName" : "CRLF1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 5878, "y" : 316 }, "minX" : 5855, "maxX" : 5918, "minY" : 299, "maxY" : 339, "prop" : { "x" : 5855, "y" : 305, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 5855, "y" : 305 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5901, "y" : 305 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5901, "y" : 305 } } }, "connectors" : [ { "edgeId" : 86671, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5897, "y" : 330 }, "to" : { "x" : 5918, "y" : 339 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86674, "reactomeId" : 10313424, "displayName" : "CRLF1:IL27", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 6049, "y" : 338 }, "minX" : 6000, "maxX" : 6104, "minY" : 321, "maxY" : 350, "prop" : { "x" : 6000, "y" : 327, "width" : 98, "height" : 23 }, "textPosition" : { "x" : 6012, "y" : 329 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6098, "y" : 327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6098, "y" : 327 } } }, "connectors" : [ { "edgeId" : 86671, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86675, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86676, "reactomeId" : 10313445, "displayName" : "CRLF1:IL27", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 6296, "y" : 336 }, "minX" : 6257, "maxX" : 6342, "minY" : 318, "maxY" : 348, "prop" : { "x" : 6257, "y" : 324, "width" : 79, "height" : 24 }, "textPosition" : { "x" : 6259, "y" : 327 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6336, "y" : 324 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6336, "y" : 324 } } }, "connectors" : [ { "edgeId" : 86675, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86679, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1682, "y" : 1181 }, "minX" : 1657, "maxX" : 1703, "minY" : 1134, "maxY" : 1196, "prop" : { "x" : 1663, "y" : 1166, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1666, "y" : 1170 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1697, "y" : 1171 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1697, "y" : 1171 } } }, "connectors" : [ { "edgeId" : 86677, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1674, "y" : 1163 }, "to" : { "x" : 1657, "y" : 1134 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1659, "y" : 1142 }, "b" : { "x" : 1671, "y" : 1154 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1665, "y" : 1148 } } }, "endShape" : { "a" : { "x" : 1667, "y" : 1159 }, "b" : { "x" : 1674, "y" : 1163 }, "c" : { "x" : 1674, "y" : 1155 }, "type" : "ARROW", "centre" : { "x" : 1674, "y" : 1155 } } } ] }, { "id" : 86678, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1560, "y" : 1180 }, "minX" : 1541, "maxX" : 1586, "minY" : 1134, "maxY" : 1195, "prop" : { "x" : 1541, "y" : 1165, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 1544, "y" : 1169 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1574, "y" : 1170 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1574, "y" : 1170 } } }, "connectors" : [ { "edgeId" : 86677, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1568, "y" : 1162 }, "to" : { "x" : 1586, "y" : 1134 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1571, "y" : 1142 }, "b" : { "x" : 1583, "y" : 1154 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1577, "y" : 1148 } } } } ] }, { "id" : 86680, "reactomeId" : 10313374, "displayName" : "IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1709, "y" : 1084 }, "minX" : 1646, "maxX" : 1807, "minY" : 1053, "maxY" : 1138, "prop" : { "x" : 1646, "y" : 1059, "width" : 127, "height" : 50 }, "textPosition" : { "x" : 1651, "y" : 1060 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1773, "y" : 1059 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1773, "y" : 1059 } } }, "connectors" : [ { "edgeId" : 86798, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1736, "y" : 1112 }, "to" : { "x" : 1769, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86798, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1776, "y" : 1090 }, "to" : { "x" : 1800, "y" : 1094 } }, { "from" : { "x" : 1800, "y" : 1094 }, "to" : { "x" : 1803, "y" : 1122 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1803, "y" : 1126 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1803, "y" : 1126 } } }, { "edgeId" : 86677, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1683, "y" : 1112 }, "to" : { "x" : 1657, "y" : 1134 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1680, "y" : 1120 }, "b" : { "x" : 1683, "y" : 1112 }, "c" : { "x" : 1675, "y" : 1113 }, "type" : "ARROW", "centre" : { "x" : 1675, "y" : 1113 } } } ] }, { "id" : 86683, "reactomeId" : 10313266, "displayName" : "p-Y693-STAT4 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2283, "y" : 1522 }, "minX" : 2219, "maxX" : 2354, "minY" : 1498, "maxY" : 1541, "prop" : { "x" : 2219, "y" : 1504, "width" : 129, "height" : 37 }, "textPosition" : { "x" : 2235, "y" : 1506 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2348, "y" : 1504 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2348, "y" : 1504 } } }, "connectors" : [ { "edgeId" : 86681, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86684, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86682, "reactomeId" : 10313264, "displayName" : "phospho-STAT4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2283, "y" : 1385 }, "minX" : 2236, "maxX" : 2336, "minY" : 1320, "maxY" : 1435, "prop" : { "x" : 2236, "y" : 1369, "width" : 94, "height" : 32 }, "textPosition" : { "x" : 2249, "y" : 1368 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2330, "y" : 1369 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2330, "y" : 1369 } } }, "connectors" : [ { "edgeId" : 86681, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2276, "y" : 1423 }, "b" : { "x" : 2288, "y" : 1435 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2282, "y" : 1429 } } } }, { "edgeId" : 86739, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2277, "y" : 1320 }, "b" : { "x" : 2289, "y" : 1332 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2283, "y" : 1326 } } } } ] }, { "id" : 86685, "reactomeId" : 10313270, "displayName" : "p-Y693-STAT4 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2284, "y" : 1671 }, "minX" : 2211, "maxX" : 2363, "minY" : 1651, "maxY" : 1685, "prop" : { "x" : 2211, "y" : 1657, "width" : 146, "height" : 28 }, "textPosition" : { "x" : 2218, "y" : 1664 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2357, "y" : 1657 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2357, "y" : 1657 } } }, "connectors" : [ { "edgeId" : 86684, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86687, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 6027, "y" : 1176 }, "minX" : 6008, "maxX" : 6061, "minY" : 1135, "maxY" : 1191, "prop" : { "x" : 6008, "y" : 1161, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 6011, "y" : 1165 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6041, "y" : 1166 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6041, "y" : 1166 } } }, "connectors" : [ { "edgeId" : 86686, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6039, "y" : 1158 }, "to" : { "x" : 6061, "y" : 1135 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 6044, "y" : 1140 }, "b" : { "x" : 6056, "y" : 1152 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6050, "y" : 1146 } } } } ] }, { "id" : 86689, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 6164, "y" : 1174 }, "minX" : 6118, "maxX" : 6185, "minY" : 1135, "maxY" : 1189, "prop" : { "x" : 6145, "y" : 1159, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 6148, "y" : 1163 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6179, "y" : 1164 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6179, "y" : 1164 } } }, "connectors" : [ { "edgeId" : 86686, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6146, "y" : 1156 }, "to" : { "x" : 6118, "y" : 1135 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 6126, "y" : 1139 }, "b" : { "x" : 6138, "y" : 1151 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6132, "y" : 1145 } } }, "endShape" : { "a" : { "x" : 6138, "y" : 1155 }, "b" : { "x" : 6146, "y" : 1156 }, "c" : { "x" : 6143, "y" : 1149 }, "type" : "ARROW", "centre" : { "x" : 6143, "y" : 1149 } } } ] }, { "id" : 86688, "reactomeId" : 10313316, "displayName" : "IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 6190, "y" : 1092 }, "minX" : 6118, "maxX" : 6317, "minY" : 1061, "maxY" : 1139, "prop" : { "x" : 6125, "y" : 1067, "width" : 130, "height" : 50 }, "textPosition" : { "x" : 6126, "y" : 1068 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6255, "y" : 1067 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6255, "y" : 1067 } } }, "connectors" : [ { "edgeId" : 86792, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6238, "y" : 1120 }, "to" : { "x" : 6282, "y" : 1139 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86792, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 6258, "y" : 1093 }, "to" : { "x" : 6312, "y" : 1094 } }, { "from" : { "x" : 6312, "y" : 1094 }, "to" : { "x" : 6313, "y" : 1122 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 6313, "y" : 1126 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6313, "y" : 1126 } } }, { "edgeId" : 86686, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6148, "y" : 1120 }, "to" : { "x" : 6118, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 6144, "y" : 1127 }, "b" : { "x" : 6148, "y" : 1120 }, "c" : { "x" : 6140, "y" : 1120 }, "type" : "ARROW", "centre" : { "x" : 6140, "y" : 1120 } } } ] }, { "id" : 86691, "reactomeId" : 10313379, "displayName" : "p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 6790, "y" : 1082 }, "minX" : 6725, "maxX" : 6861, "minY" : 1029, "maxY" : 1159, "prop" : { "x" : 6726, "y" : 1035, "width" : 129, "height" : 95 }, "textPosition" : { "x" : 6726, "y" : 1039 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6855, "y" : 1035 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6855, "y" : 1035 } } }, "connectors" : [ { "edgeId" : 86690, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86695, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6749, "y" : 1133 }, "to" : { "x" : 6725, "y" : 1159 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 6747, "y" : 1141 }, "b" : { "x" : 6749, "y" : 1133 }, "c" : { "x" : 6741, "y" : 1135 }, "type" : "ARROW", "centre" : { "x" : 6741, "y" : 1135 } } } ] }, { "id" : 86693, "reactomeId" : 10265407, "displayName" : "phospho-STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 6643, "y" : 1382 }, "minX" : 6585, "maxX" : 6696, "minY" : 1279, "maxY" : 1432, "prop" : { "x" : 6597, "y" : 1365, "width" : 93, "height" : 34 }, "textPosition" : { "x" : 6610, "y" : 1365 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6690, "y" : 1365 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6690, "y" : 1365 } } }, "connectors" : [ { "edgeId" : 86791, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6623, "y" : 1402 }, "to" : { "x" : 6585, "y" : 1432 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86690, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6635, "y" : 1362 }, "to" : { "x" : 6600, "y" : 1279 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 6629, "y" : 1357 }, "b" : { "x" : 6635, "y" : 1362 }, "c" : { "x" : 6636, "y" : 1354 }, "type" : "ARROW", "centre" : { "x" : 6636, "y" : 1354 } } } ] }, { "id" : 86692, "reactomeId" : 10313381, "displayName" : "IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 6588, "y" : 1088 }, "minX" : 6523, "maxX" : 6698, "minY" : 1043, "maxY" : 1279, "prop" : { "x" : 6523, "y" : 1049, "width" : 130, "height" : 78 }, "textPosition" : { "x" : 6524, "y" : 1050 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6653, "y" : 1049 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6653, "y" : 1049 } } }, "connectors" : [ { "edgeId" : 86690, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6590, "y" : 1130 }, "to" : { "x" : 6600, "y" : 1279 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 6594, "y" : 1137 }, "b" : { "x" : 6590, "y" : 1130 }, "c" : { "x" : 6586, "y" : 1137 }, "type" : "ARROW", "centre" : { "x" : 6586, "y" : 1137 } } }, { "edgeId" : 86695, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6628, "y" : 1130 }, "to" : { "x" : 6663, "y" : 1160 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86695, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 6656, "y" : 1101 }, "to" : { "x" : 6696, "y" : 1111 } }, { "from" : { "x" : 6696, "y" : 1111 }, "to" : { "x" : 6694, "y" : 1144 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 6694, "y" : 1148 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6694, "y" : 1148 } } }, { "edgeId" : 86728, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86694, "reactomeId" : 10260725, "displayName" : "phospho-STAT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 6525, "y" : 1385 }, "minX" : 6480, "maxX" : 6600, "minY" : 1279, "maxY" : 1432, "prop" : { "x" : 6480, "y" : 1366, "width" : 91, "height" : 38 }, "textPosition" : { "x" : 6492, "y" : 1367 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6571, "y" : 1366 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6571, "y" : 1366 } } }, "connectors" : [ { "edgeId" : 86791, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6549, "y" : 1407 }, "to" : { "x" : 6585, "y" : 1432 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86690, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6538, "y" : 1363 }, "to" : { "x" : 6600, "y" : 1279 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 6539, "y" : 1355 }, "b" : { "x" : 6538, "y" : 1363 }, "c" : { "x" : 6545, "y" : 1360 }, "type" : "ARROW", "centre" : { "x" : 6545, "y" : 1360 } } } ] }, { "id" : 86697, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 6761, "y" : 1207 }, "minX" : 6725, "maxX" : 6782, "minY" : 1159, "maxY" : 1222, "prop" : { "x" : 6742, "y" : 1192, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 6745, "y" : 1196 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6776, "y" : 1197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6776, "y" : 1197 } } }, "connectors" : [ { "edgeId" : 86695, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6749, "y" : 1189 }, "to" : { "x" : 6725, "y" : 1159 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 6731, "y" : 1168 }, "b" : { "x" : 6743, "y" : 1180 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6737, "y" : 1174 } } }, "endShape" : { "a" : { "x" : 6742, "y" : 1186 }, "b" : { "x" : 6749, "y" : 1189 }, "c" : { "x" : 6748, "y" : 1181 }, "type" : "ARROW", "centre" : { "x" : 6748, "y" : 1181 } } } ] }, { "id" : 86696, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 6619, "y" : 1206 }, "minX" : 6600, "maxX" : 6663, "minY" : 1160, "maxY" : 1221, "prop" : { "x" : 6600, "y" : 1191, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 6603, "y" : 1195 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6633, "y" : 1196 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6633, "y" : 1196 } } }, "connectors" : [ { "edgeId" : 86695, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6633, "y" : 1188 }, "to" : { "x" : 6663, "y" : 1160 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 6642, "y" : 1168 }, "b" : { "x" : 6654, "y" : 1180 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6648, "y" : 1174 } } } } ] }, { "id" : 86699, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 923, "y" : 1186 }, "minX" : 904, "maxX" : 963, "minY" : 1134, "maxY" : 1201, "prop" : { "x" : 904, "y" : 1171, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 907, "y" : 1175 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 937, "y" : 1176 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 937, "y" : 1176 } } }, "connectors" : [ { "edgeId" : 86698, "type" : "INPUT", "segments" : [ { "from" : { "x" : 934, "y" : 1168 }, "to" : { "x" : 963, "y" : 1134 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 942, "y" : 1145 }, "b" : { "x" : 954, "y" : 1157 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 948, "y" : 1151 } } } } ] }, { "id" : 86701, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1068, "y" : 1182 }, "minX" : 1024, "maxX" : 1089, "minY" : 1133, "maxY" : 1197, "prop" : { "x" : 1049, "y" : 1167, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 1052, "y" : 1171 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1083, "y" : 1172 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1083, "y" : 1172 } } }, "connectors" : [ { "edgeId" : 86698, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1054, "y" : 1164 }, "to" : { "x" : 1024, "y" : 1133 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1033, "y" : 1142 }, "b" : { "x" : 1045, "y" : 1154 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1039, "y" : 1148 } } }, "endShape" : { "a" : { "x" : 1046, "y" : 1162 }, "b" : { "x" : 1054, "y" : 1164 }, "c" : { "x" : 1052, "y" : 1156 }, "type" : "ARROW", "centre" : { "x" : 1052, "y" : 1156 } } } ] }, { "id" : 86700, "reactomeId" : 10313297, "displayName" : "IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 919, "y" : 1079 }, "minX" : 856, "maxX" : 1005, "minY" : 1041, "maxY" : 1134, "prop" : { "x" : 856, "y" : 1047, "width" : 126, "height" : 64 }, "textPosition" : { "x" : 860, "y" : 1048 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 982, "y" : 1047 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 982, "y" : 1047 } } }, "connectors" : [ { "edgeId" : 86698, "type" : "INPUT", "segments" : [ { "from" : { "x" : 944, "y" : 1114 }, "to" : { "x" : 963, "y" : 1134 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86698, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 985, "y" : 1079 }, "to" : { "x" : 1003, "y" : 1079 } }, { "from" : { "x" : 1003, "y" : 1079 }, "to" : { "x" : 1002, "y" : 1117 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1001, "y" : 1121 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1001, "y" : 1121 } } }, { "edgeId" : 86734, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86702, "reactomeId" : 10313299, "displayName" : "IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1099, "y" : 1089 }, "minX" : 1024, "maxX" : 1169, "minY" : 1044, "maxY" : 1133, "prop" : { "x" : 1036, "y" : 1050, "width" : 127, "height" : 78 }, "textPosition" : { "x" : 1040, "y" : 1051 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1163, "y" : 1050 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1163, "y" : 1050 } } }, "connectors" : [ { "edgeId" : 86698, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1033, "y" : 1126 }, "to" : { "x" : 1024, "y" : 1133 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1030, "y" : 1133 }, "b" : { "x" : 1033, "y" : 1126 }, "c" : { "x" : 1025, "y" : 1127 }, "type" : "ARROW", "centre" : { "x" : 1025, "y" : 1127 } } }, { "edgeId" : 86737, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86705, "reactomeId" : 10265407, "displayName" : "phospho-STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1189, "y" : 1362 }, "minX" : 1126, "maxX" : 1242, "minY" : 1238, "maxY" : 1421, "prop" : { "x" : 1142, "y" : 1347, "width" : 94, "height" : 31 }, "textPosition" : { "x" : 1155, "y" : 1345 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1236, "y" : 1347 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1236, "y" : 1347 } } }, "connectors" : [ { "edgeId" : 86703, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1173, "y" : 1381 }, "to" : { "x" : 1131, "y" : 1421 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86737, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1181, "y" : 1344 }, "to" : { "x" : 1126, "y" : 1238 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1174, "y" : 1340 }, "b" : { "x" : 1181, "y" : 1344 }, "c" : { "x" : 1181, "y" : 1336 }, "type" : "ARROW", "centre" : { "x" : 1181, "y" : 1336 } } } ] }, { "id" : 86704, "reactomeId" : 10313264, "displayName" : "phospho-STAT4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1064, "y" : 1364 }, "minX" : 1017, "maxX" : 1131, "minY" : 1238, "maxY" : 1421, "prop" : { "x" : 1017, "y" : 1350, "width" : 94, "height" : 29 }, "textPosition" : { "x" : 1030, "y" : 1347 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1111, "y" : 1350 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1111, "y" : 1350 } } }, "connectors" : [ { "edgeId" : 86703, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1081, "y" : 1382 }, "to" : { "x" : 1131, "y" : 1421 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86737, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1071, "y" : 1347 }, "to" : { "x" : 1126, "y" : 1238 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1071, "y" : 1339 }, "b" : { "x" : 1071, "y" : 1347 }, "c" : { "x" : 1078, "y" : 1343 }, "type" : "ARROW", "centre" : { "x" : 1078, "y" : 1343 } } } ] }, { "id" : 86706, "reactomeId" : 10313439, "displayName" : "p-Y705-STAT3:p-Y693-STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1135, "y" : 1519 }, "minX" : 1079, "maxX" : 1198, "minY" : 1495, "maxY" : 1537, "prop" : { "x" : 1079, "y" : 1501, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 1081, "y" : 1502 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1192, "y" : 1501 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1192, "y" : 1501 } } }, "connectors" : [ { "edgeId" : 86703, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86707, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86708, "reactomeId" : 10313441, "displayName" : "p-Y705-STAT3:p-Y693-STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1134, "y" : 1656 }, "minX" : 1078, "maxX" : 1197, "minY" : 1632, "maxY" : 1674, "prop" : { "x" : 1078, "y" : 1638, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 1080, "y" : 1639 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1191, "y" : 1638 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1191, "y" : 1638 } } }, "connectors" : [ { "edgeId" : 86707, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86711, "reactomeId" : 10313363, "displayName" : "IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4843, "y" : 1099 }, "minX" : 4787, "maxX" : 4966, "minY" : 1069, "maxY" : 1295, "prop" : { "x" : 4787, "y" : 1075, "width" : 113, "height" : 49 }, "textPosition" : { "x" : 4792, "y" : 1075 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4900, "y" : 1075 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4900, "y" : 1075 } } }, "connectors" : [ { "edgeId" : 86788, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4850, "y" : 1127 }, "to" : { "x" : 4885, "y" : 1228 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86790, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 4858, "y" : 1127 }, "to" : { "x" : 4966, "y" : 1295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4865, "y" : 1131 }, "b" : { "x" : 4858, "y" : 1127 }, "c" : { "x" : 4858, "y" : 1135 }, "type" : "ARROW", "centre" : { "x" : 4858, "y" : 1135 } } }, { "edgeId" : 86709, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 4827, "y" : 1127 }, "to" : { "x" : 4810, "y" : 1151 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4826, "y" : 1135 }, "b" : { "x" : 4827, "y" : 1127 }, "c" : { "x" : 4820, "y" : 1130 }, "type" : "ARROW", "centre" : { "x" : 4820, "y" : 1130 } } } ] }, { "id" : 86710, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 4670, "y" : 1191 }, "minX" : 4651, "maxX" : 4710, "minY" : 1151, "maxY" : 1206, "prop" : { "x" : 4651, "y" : 1176, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 4654, "y" : 1180 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4684, "y" : 1181 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4684, "y" : 1181 } } }, "connectors" : [ { "edgeId" : 86709, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4685, "y" : 1173 }, "to" : { "x" : 4710, "y" : 1151 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 4691, "y" : 1156 }, "b" : { "x" : 4703, "y" : 1168 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 4697, "y" : 1162 } } } } ] }, { "id" : 86712, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 4837, "y" : 1195 }, "minX" : 4810, "maxX" : 4858, "minY" : 1151, "maxY" : 1210, "prop" : { "x" : 4818, "y" : 1180, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 4821, "y" : 1184 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4852, "y" : 1185 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4852, "y" : 1185 } } }, "connectors" : [ { "edgeId" : 86709, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 4827, "y" : 1177 }, "to" : { "x" : 4810, "y" : 1151 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 4812, "y" : 1158 }, "b" : { "x" : 4824, "y" : 1170 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 4818, "y" : 1164 } } }, "endShape" : { "a" : { "x" : 4820, "y" : 1173 }, "b" : { "x" : 4827, "y" : 1177 }, "c" : { "x" : 4827, "y" : 1169 }, "type" : "ARROW", "centre" : { "x" : 4827, "y" : 1169 } } } ] }, { "id" : 86715, "reactomeId" : 10313432, "displayName" : "p-Y693-STAT4:p-Y701-STAT1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4362, "y" : 1648 }, "minX" : 4306, "maxX" : 4425, "minY" : 1624, "maxY" : 1666, "prop" : { "x" : 4306, "y" : 1630, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 4308, "y" : 1631 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4419, "y" : 1630 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4419, "y" : 1630 } } }, "connectors" : [ { "edgeId" : 86713, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86714, "reactomeId" : 10313430, "displayName" : "p-STAT1:p-STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4879, "y" : 1388 }, "minX" : 4823, "maxX" : 4966, "minY" : 1295, "maxY" : 1407, "prop" : { "x" : 4823, "y" : 1369, "width" : 113, "height" : 38 }, "textPosition" : { "x" : 4823, "y" : 1386 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4936, "y" : 1369 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4936, "y" : 1369 } } }, "connectors" : [ { "edgeId" : 86790, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 4896, "y" : 1366 }, "to" : { "x" : 4966, "y" : 1295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4898, "y" : 1358 }, "b" : { "x" : 4896, "y" : 1366 }, "c" : { "x" : 4904, "y" : 1364 }, "type" : "ARROW", "centre" : { "x" : 4904, "y" : 1364 } } }, { "edgeId" : 86713, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86717, "reactomeId" : 10265413, "displayName" : "p-Y701-STAT1: p-Y-705-STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 6589, "y" : 1524 }, "minX" : 6533, "maxX" : 6652, "minY" : 1500, "maxY" : 1542, "prop" : { "x" : 6533, "y" : 1506, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 6533, "y" : 1507 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6646, "y" : 1506 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6646, "y" : 1506 } } }, "connectors" : [ { "edgeId" : 86791, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86716, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86718, "reactomeId" : 10265431, "displayName" : "p-Y701-STAT1:p-Y705-STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 6590, "y" : 1676 }, "minX" : 6534, "maxX" : 6653, "minY" : 1652, "maxY" : 1694, "prop" : { "x" : 6534, "y" : 1658, "width" : 113, "height" : 36 }, "textPosition" : { "x" : 6536, "y" : 1659 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6647, "y" : 1658 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6647, "y" : 1658 } } }, "connectors" : [ { "edgeId" : 86716, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86721, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 5014, "y" : 1207 }, "minX" : 4995, "maxX" : 5034, "minY" : 1158, "maxY" : 1222, "prop" : { "x" : 4995, "y" : 1192, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 4998, "y" : 1196 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5028, "y" : 1197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5028, "y" : 1197 } } }, "connectors" : [ { "edgeId" : 86719, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5018, "y" : 1189 }, "to" : { "x" : 5030, "y" : 1158 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 5018, "y" : 1167 }, "b" : { "x" : 5030, "y" : 1179 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 5024, "y" : 1173 } } } } ] }, { "id" : 86720, "reactomeId" : 10313402, "displayName" : "IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4992, "y" : 1089 }, "minX" : 4936, "maxX" : 5080, "minY" : 1052, "maxY" : 1158, "prop" : { "x" : 4936, "y" : 1058, "width" : 113, "height" : 62 }, "textPosition" : { "x" : 4941, "y" : 1057 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5049, "y" : 1058 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5049, "y" : 1058 } } }, "connectors" : [ { "edgeId" : 86788, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86719, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5009, "y" : 1123 }, "to" : { "x" : 5030, "y" : 1158 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86719, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 5052, "y" : 1113 }, "to" : { "x" : 5073, "y" : 1124 } }, { "from" : { "x" : 5073, "y" : 1124 }, "to" : { "x" : 5075, "y" : 1142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 5076, "y" : 1146 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5076, "y" : 1146 } } } ] }, { "id" : 86723, "reactomeId" : 10313410, "displayName" : "IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 5145, "y" : 1086 }, "minX" : 5087, "maxX" : 5209, "minY" : 1048, "maxY" : 1157, "prop" : { "x" : 5087, "y" : 1054, "width" : 116, "height" : 65 }, "textPosition" : { "x" : 5087, "y" : 1070 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5203, "y" : 1054 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5203, "y" : 1054 } } }, "connectors" : [ { "edgeId" : 86790, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86719, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 5133, "y" : 1122 }, "to" : { "x" : 5119, "y" : 1157 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 5134, "y" : 1130 }, "b" : { "x" : 5133, "y" : 1122 }, "c" : { "x" : 5127, "y" : 1127 }, "type" : "ARROW", "centre" : { "x" : 5127, "y" : 1127 } } } ] }, { "id" : 86722, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 5139, "y" : 1197 }, "minX" : 5119, "maxX" : 5160, "minY" : 1157, "maxY" : 1212, "prop" : { "x" : 5120, "y" : 1182, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 5123, "y" : 1186 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5154, "y" : 1187 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5154, "y" : 1187 } } }, "connectors" : [ { "edgeId" : 86719, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 5131, "y" : 1179 }, "to" : { "x" : 5119, "y" : 1157 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 5119, "y" : 1162 }, "b" : { "x" : 5131, "y" : 1174 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 5125, "y" : 1168 } } }, "endShape" : { "a" : { "x" : 5124, "y" : 1175 }, "b" : { "x" : 5131, "y" : 1179 }, "c" : { "x" : 5131, "y" : 1171 }, "type" : "ARROW", "centre" : { "x" : 5131, "y" : 1171 } } } ] }, { "id" : 86725, "reactomeId" : 10313283, "displayName" : "STAT4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1943, "y" : 1181 }, "minX" : 1918, "maxX" : 1974, "minY" : 1138, "maxY" : 1192, "prop" : { "x" : 1918, "y" : 1170, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 1920, "y" : 1170 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1968, "y" : 1170 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1968, "y" : 1170 } } }, "connectors" : [ { "edgeId" : 86724, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1949, "y" : 1167 }, "to" : { "x" : 1970, "y" : 1138 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1953, "y" : 1146 }, "b" : { "x" : 1965, "y" : 1158 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1959, "y" : 1152 } } } } ] }, { "id" : 86727, "reactomeId" : 10313396, "displayName" : "IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2073, "y" : 1076 }, "minX" : 2010, "maxX" : 2143, "minY" : 1038, "maxY" : 1108, "prop" : { "x" : 2010, "y" : 1044, "width" : 127, "height" : 64 }, "textPosition" : { "x" : 2015, "y" : 1045 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2137, "y" : 1044 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2137, "y" : 1044 } } }, "connectors" : [ { "edgeId" : 86724, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86726, "reactomeId" : 10313394, "displayName" : "IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1889, "y" : 1073 }, "minX" : 1826, "maxX" : 1970, "minY" : 1034, "maxY" : 1139, "prop" : { "x" : 1826, "y" : 1040, "width" : 127, "height" : 66 }, "textPosition" : { "x" : 1831, "y" : 1043 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1953, "y" : 1040 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1953, "y" : 1040 } } }, "connectors" : [ { "edgeId" : 86798, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1860, "y" : 1109 }, "to" : { "x" : 1832, "y" : 1139 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1858, "y" : 1117 }, "b" : { "x" : 1860, "y" : 1109 }, "c" : { "x" : 1852, "y" : 1111 }, "type" : "ARROW", "centre" : { "x" : 1852, "y" : 1111 } } }, { "edgeId" : 86724, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1930, "y" : 1109 }, "to" : { "x" : 1970, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86729, "reactomeId" : 10313328, "displayName" : "IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 6427, "y" : 1087 }, "minX" : 6346, "maxX" : 6498, "minY" : 1049, "maxY" : 1163, "prop" : { "x" : 6362, "y" : 1055, "width" : 130, "height" : 64 }, "textPosition" : { "x" : 6363, "y" : 1056 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6492, "y" : 1055 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6492, "y" : 1055 } } }, "connectors" : [ { "edgeId" : 86792, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 6377, "y" : 1122 }, "to" : { "x" : 6346, "y" : 1139 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 6373, "y" : 1129 }, "b" : { "x" : 6377, "y" : 1122 }, "c" : { "x" : 6369, "y" : 1122 }, "type" : "ARROW", "centre" : { "x" : 6369, "y" : 1122 } } }, { "edgeId" : 86728, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6451, "y" : 1122 }, "to" : { "x" : 6484, "y" : 1163 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86731, "reactomeId" : 10252150, "displayName" : "STAT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 6443, "y" : 1182 }, "minX" : 6418, "maxX" : 6484, "minY" : 1163, "maxY" : 1194, "prop" : { "x" : 6418, "y" : 1171, "width" : 50, "height" : 23 }, "textPosition" : { "x" : 6420, "y" : 1172 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6468, "y" : 1171 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6468, "y" : 1171 } } }, "connectors" : [ { "edgeId" : 86728, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6467, "y" : 1168 }, "to" : { "x" : 6484, "y" : 1163 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86730, "reactomeId" : 10252138, "displayName" : "STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 6475, "y" : 1220 }, "minX" : 6448, "maxX" : 6509, "minY" : 1163, "maxY" : 1231, "prop" : { "x" : 6448, "y" : 1209, "width" : 55, "height" : 22 }, "textPosition" : { "x" : 6452, "y" : 1209 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 6503, "y" : 1209 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 6503, "y" : 1209 } } }, "connectors" : [ { "edgeId" : 86728, "type" : "INPUT", "segments" : [ { "from" : { "x" : 6476, "y" : 1206 }, "to" : { "x" : 6484, "y" : 1163 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86735, "reactomeId" : 10313295, "displayName" : "IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 757, "y" : 1084 }, "minX" : 694, "maxX" : 827, "minY" : 1049, "maxY" : 1131, "prop" : { "x" : 694, "y" : 1055, "width" : 127, "height" : 59 }, "textPosition" : { "x" : 698, "y" : 1051 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 821, "y" : 1055 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 821, "y" : 1055 } } }, "connectors" : [ { "edgeId" : 86734, "type" : "INPUT", "segments" : [ { "from" : { "x" : 790, "y" : 1117 }, "to" : { "x" : 811, "y" : 1131 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86736, "reactomeId" : 10313283, "displayName" : "STAT4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 781, "y" : 1189 }, "minX" : 756, "maxX" : 812, "minY" : 1131, "maxY" : 1200, "prop" : { "x" : 756, "y" : 1178, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 758, "y" : 1178 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 806, "y" : 1178 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 806, "y" : 1178 } } }, "connectors" : [ { "edgeId" : 86734, "type" : "INPUT", "segments" : [ { "from" : { "x" : 786, "y" : 1175 }, "to" : { "x" : 811, "y" : 1131 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86738, "reactomeId" : 10313293, "displayName" : "IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 588, "y" : 1091 }, "minX" : 525, "maxX" : 1126, "minY" : 1060, "maxY" : 1238, "prop" : { "x" : 525, "y" : 1066, "width" : 127, "height" : 50 }, "textPosition" : { "x" : 529, "y" : 1067 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 652, "y" : 1066 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 652, "y" : 1066 } } }, "connectors" : [ { "edgeId" : 86737, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 609, "y" : 1119 }, "to" : { "x" : 710, "y" : 1236 } }, { "from" : { "x" : 710, "y" : 1236 }, "to" : { "x" : 1126, "y" : 1238 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 617, "y" : 1122 }, "b" : { "x" : 609, "y" : 1119 }, "c" : { "x" : 610, "y" : 1127 }, "type" : "ARROW", "centre" : { "x" : 610, "y" : 1127 } } } ] }, { "id" : 86740, "reactomeId" : 10314502, "displayName" : "2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2283, "y" : 1073 }, "minX" : 2220, "maxX" : 2352, "minY" : 1028, "maxY" : 1112, "prop" : { "x" : 2220, "y" : 1034, "width" : 126, "height" : 78 }, "textPosition" : { "x" : 2224, "y" : 1035 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2346, "y" : 1034 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2346, "y" : 1034 } } }, "connectors" : [ { "edgeId" : 86739, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86743, "reactomeId" : 10315557, "displayName" : "IL35:(IL12RB2:JAK2 dimer)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2662, "y" : 1096 }, "minX" : 2603, "maxX" : 2728, "minY" : 1072, "maxY" : 1147, "prop" : { "x" : 2603, "y" : 1078, "width" : 119, "height" : 36 }, "textPosition" : { "x" : 2615, "y" : 1079 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2722, "y" : 1078 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2722, "y" : 1078 } } }, "connectors" : [ { "edgeId" : 86742, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86760, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2671, "y" : 1117 }, "to" : { "x" : 2688, "y" : 1147 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86745, "reactomeId" : 10315553, "displayName" : "IL-35:(IL6ST:JAK1:JAK2) dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4561, "y" : 1098 }, "minX" : 4506, "maxX" : 4622, "minY" : 1074, "maxY" : 1146, "prop" : { "x" : 4506, "y" : 1080, "width" : 110, "height" : 36 }, "textPosition" : { "x" : 4507, "y" : 1081 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4616, "y" : 1080 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4616, "y" : 1080 } } }, "connectors" : [ { "edgeId" : 86744, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86746, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4551, "y" : 1119 }, "to" : { "x" : 4536, "y" : 1146 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86747, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 4572, "y" : 1184 }, "minX" : 4536, "maxX" : 4592, "minY" : 1146, "maxY" : 1199, "prop" : { "x" : 4553, "y" : 1169, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 4556, "y" : 1173 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4586, "y" : 1174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4586, "y" : 1174 } } }, "connectors" : [ { "edgeId" : 86746, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4557, "y" : 1166 }, "to" : { "x" : 4536, "y" : 1146 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 4540, "y" : 1150 }, "b" : { "x" : 4552, "y" : 1162 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 4546, "y" : 1156 } } } } ] }, { "id" : 86749, "reactomeId" : 10315565, "displayName" : "IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4414, "y" : 1101 }, "minX" : 4356, "maxX" : 4479, "minY" : 1070, "maxY" : 1147, "prop" : { "x" : 4356, "y" : 1076, "width" : 117, "height" : 50 }, "textPosition" : { "x" : 4368, "y" : 1077 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4473, "y" : 1076 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4473, "y" : 1076 } } }, "connectors" : [ { "edgeId" : 86746, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 4428, "y" : 1129 }, "to" : { "x" : 4441, "y" : 1147 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4435, "y" : 1132 }, "b" : { "x" : 4428, "y" : 1129 }, "c" : { "x" : 4429, "y" : 1137 }, "type" : "ARROW", "centre" : { "x" : 4429, "y" : 1137 } } } ] }, { "id" : 86748, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 4414, "y" : 1194 }, "minX" : 4395, "maxX" : 4441, "minY" : 1147, "maxY" : 1209, "prop" : { "x" : 4395, "y" : 1179, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 4398, "y" : 1183 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4429, "y" : 1184 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4429, "y" : 1184 } } }, "connectors" : [ { "edgeId" : 86746, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 4422, "y" : 1176 }, "to" : { "x" : 4441, "y" : 1147 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 4425, "y" : 1155 }, "b" : { "x" : 4437, "y" : 1167 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 4431, "y" : 1161 } } }, "endShape" : { "a" : { "x" : 4422, "y" : 1168 }, "b" : { "x" : 4422, "y" : 1176 }, "c" : { "x" : 4429, "y" : 1172 }, "type" : "ARROW", "centre" : { "x" : 4429, "y" : 1172 } } } ] }, { "id" : 86751, "reactomeId" : 10315569, "displayName" : "IL-35:(IL6ST:p-JAK1:p-JAK2) dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4266, "y" : 1092 }, "minX" : 3998, "maxX" : 4341, "minY" : 1067, "maxY" : 1205, "prop" : { "x" : 4198, "y" : 1073, "width" : 137, "height" : 38 }, "textPosition" : { "x" : 4198, "y" : 1076 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4335, "y" : 1073 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4335, "y" : 1073 } } }, "connectors" : [ { "edgeId" : 86750, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4262, "y" : 1114 }, "to" : { "x" : 4253, "y" : 1169 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86758, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 4220, "y" : 1114 }, "to" : { "x" : 3998, "y" : 1205 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 4215, "y" : 1120 }, "b" : { "x" : 4220, "y" : 1114 }, "c" : { "x" : 4212, "y" : 1113 }, "type" : "ARROW", "centre" : { "x" : 4212, "y" : 1113 } } } ] }, { "id" : 86753, "reactomeId" : 10315571, "displayName" : "IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4033, "y" : 1089 }, "minX" : 3971, "maxX" : 4101, "minY" : 1058, "maxY" : 1134, "prop" : { "x" : 3971, "y" : 1064, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 3971, "y" : 1065 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4095, "y" : 1064 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4095, "y" : 1064 } } }, "connectors" : [ { "edgeId" : 86750, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86754, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4012, "y" : 1117 }, "to" : { "x" : 3996, "y" : 1134 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86752, "reactomeId" : 10252150, "displayName" : "STAT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 4328, "y" : 1239 }, "minX" : 3583, "maxX" : 4885, "minY" : 1169, "maxY" : 1250, "prop" : { "x" : 4297, "y" : 1229, "width" : 62, "height" : 21 }, "textPosition" : { "x" : 4305, "y" : 1229 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4359, "y" : 1229 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4359, "y" : 1229 } } }, "connectors" : [ { "edgeId" : 86788, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4362, "y" : 1238 }, "to" : { "x" : 4885, "y" : 1228 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86750, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4316, "y" : 1226 }, "to" : { "x" : 4253, "y" : 1169 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86779, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4294, "y" : 1239 }, "to" : { "x" : 3583, "y" : 1247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86755, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 4044, "y" : 1163 }, "minX" : 3996, "maxX" : 4064, "minY" : 1134, "maxY" : 1178, "prop" : { "x" : 4025, "y" : 1148, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 4028, "y" : 1152 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4058, "y" : 1153 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4058, "y" : 1153 } } }, "connectors" : [ { "edgeId" : 86754, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4022, "y" : 1151 }, "to" : { "x" : 3996, "y" : 1134 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86757, "reactomeId" : 10315573, "displayName" : "IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3893, "y" : 1088 }, "minX" : 3831, "maxX" : 3961, "minY" : 1057, "maxY" : 1133, "prop" : { "x" : 3831, "y" : 1063, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 3831, "y" : 1064 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3955, "y" : 1063 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3955, "y" : 1063 } } }, "connectors" : [ { "edgeId" : 86754, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3914, "y" : 1116 }, "to" : { "x" : 3931, "y" : 1133 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3922, "y" : 1118 }, "b" : { "x" : 3914, "y" : 1116 }, "c" : { "x" : 3916, "y" : 1124 }, "type" : "ARROW", "centre" : { "x" : 3916, "y" : 1124 } } }, { "edgeId" : 86758, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86756, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3894, "y" : 1166 }, "minX" : 3875, "maxX" : 3931, "minY" : 1133, "maxY" : 1181, "prop" : { "x" : 3875, "y" : 1151, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 3878, "y" : 1155 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3909, "y" : 1156 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3909, "y" : 1156 } } }, "connectors" : [ { "edgeId" : 86754, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3910, "y" : 1148 }, "to" : { "x" : 3931, "y" : 1133 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3913, "y" : 1141 }, "b" : { "x" : 3910, "y" : 1148 }, "c" : { "x" : 3918, "y" : 1147 }, "type" : "ARROW", "centre" : { "x" : 3918, "y" : 1147 } } } ] }, { "id" : 86759, "reactomeId" : 10313408, "displayName" : "phospho-STAT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3967, "y" : 1338 }, "minX" : 3508, "maxX" : 4008, "minY" : 1205, "maxY" : 1352, "prop" : { "x" : 3933, "y" : 1325, "width" : 69, "height" : 27 }, "textPosition" : { "x" : 3934, "y" : 1321 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4002, "y" : 1325 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4002, "y" : 1325 } } }, "connectors" : [ { "edgeId" : 86786, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3930, "y" : 1338 }, "to" : { "x" : 3508, "y" : 1341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3923, "y" : 1342 }, "b" : { "x" : 3930, "y" : 1338 }, "c" : { "x" : 3923, "y" : 1334 }, "type" : "ARROW", "centre" : { "x" : 3923, "y" : 1334 } } }, { "edgeId" : 86758, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3970, "y" : 1322 }, "to" : { "x" : 3998, "y" : 1205 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3968, "y" : 1314 }, "b" : { "x" : 3970, "y" : 1322 }, "c" : { "x" : 3976, "y" : 1316 }, "type" : "ARROW", "centre" : { "x" : 3976, "y" : 1316 } } } ] }, { "id" : 86761, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2654, "y" : 1189 }, "minX" : 2635, "maxX" : 2688, "minY" : 1147, "maxY" : 1204, "prop" : { "x" : 2635, "y" : 1174, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 2638, "y" : 1178 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2668, "y" : 1179 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2668, "y" : 1179 } } }, "connectors" : [ { "edgeId" : 86760, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2666, "y" : 1171 }, "to" : { "x" : 2688, "y" : 1147 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2671, "y" : 1153 }, "b" : { "x" : 2683, "y" : 1165 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2677, "y" : 1159 } } } } ] }, { "id" : 86763, "reactomeId" : 10315581, "displayName" : "IL35:(IL12RB2:p-JAK2) dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2801, "y" : 1094 }, "minX" : 2742, "maxX" : 2870, "minY" : 1070, "maxY" : 1236, "prop" : { "x" : 2750, "y" : 1076, "width" : 103, "height" : 36 }, "textPosition" : { "x" : 2754, "y" : 1077 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2853, "y" : 1076 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2853, "y" : 1076 } } }, "connectors" : [ { "edgeId" : 86760, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2780, "y" : 1115 }, "to" : { "x" : 2742, "y" : 1147 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2777, "y" : 1123 }, "b" : { "x" : 2780, "y" : 1115 }, "c" : { "x" : 2772, "y" : 1116 }, "type" : "ARROW", "centre" : { "x" : 2772, "y" : 1116 } } }, { "edgeId" : 86764, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2837, "y" : 1115 }, "to" : { "x" : 2870, "y" : 1128 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86771, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2809, "y" : 1115 }, "to" : { "x" : 2868, "y" : 1236 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2816, "y" : 1119 }, "b" : { "x" : 2809, "y" : 1115 }, "c" : { "x" : 2808, "y" : 1123 }, "type" : "ARROW", "centre" : { "x" : 2808, "y" : 1123 } } } ] }, { "id" : 86762, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2761, "y" : 1187 }, "minX" : 2741, "maxX" : 2782, "minY" : 1147, "maxY" : 1202, "prop" : { "x" : 2742, "y" : 1172, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2745, "y" : 1176 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2776, "y" : 1177 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2776, "y" : 1177 } } }, "connectors" : [ { "edgeId" : 86760, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2753, "y" : 1169 }, "to" : { "x" : 2742, "y" : 1147 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2741, "y" : 1152 }, "b" : { "x" : 2753, "y" : 1164 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2747, "y" : 1158 } } }, "endShape" : { "a" : { "x" : 2746, "y" : 1165 }, "b" : { "x" : 2753, "y" : 1169 }, "c" : { "x" : 2753, "y" : 1161 }, "type" : "ARROW", "centre" : { "x" : 2753, "y" : 1161 } } } ] }, { "id" : 86765, "reactomeId" : 10313283, "displayName" : "STAT4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2880, "y" : 1161 }, "minX" : 2855, "maxX" : 2911, "minY" : 1128, "maxY" : 1173, "prop" : { "x" : 2855, "y" : 1150, "width" : 50, "height" : 23 }, "textPosition" : { "x" : 2857, "y" : 1151 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2905, "y" : 1150 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2905, "y" : 1150 } } }, "connectors" : [ { "edgeId" : 86764, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2876, "y" : 1147 }, "to" : { "x" : 2870, "y" : 1128 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86766, "reactomeId" : 10315585, "displayName" : "IL35:(IL12RB2:p-JAK2) dimer:STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2954, "y" : 1086 }, "minX" : 2898, "maxX" : 3038, "minY" : 1055, "maxY" : 1138, "prop" : { "x" : 2898, "y" : 1061, "width" : 112, "height" : 51 }, "textPosition" : { "x" : 2900, "y" : 1063 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3010, "y" : 1061 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3010, "y" : 1061 } } }, "connectors" : [ { "edgeId" : 86764, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86767, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2975, "y" : 1115 }, "to" : { "x" : 2998, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86767, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3013, "y" : 1099 }, "to" : { "x" : 3031, "y" : 1104 } }, { "from" : { "x" : 3031, "y" : 1104 }, "to" : { "x" : 3033, "y" : 1120 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3034, "y" : 1124 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3034, "y" : 1124 } } } ] }, { "id" : 86769, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3086, "y" : 1171 }, "minX" : 3067, "maxX" : 3107, "minY" : 1135, "maxY" : 1186, "prop" : { "x" : 3067, "y" : 1156, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 3070, "y" : 1160 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3101, "y" : 1161 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3101, "y" : 1161 } } }, "connectors" : [ { "edgeId" : 86767, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3078, "y" : 1153 }, "to" : { "x" : 3068, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3071, "y" : 1149 }, "b" : { "x" : 3078, "y" : 1153 }, "c" : { "x" : 3078, "y" : 1145 }, "type" : "ARROW", "centre" : { "x" : 3078, "y" : 1145 } } } ] }, { "id" : 86768, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2975, "y" : 1168 }, "minX" : 2956, "maxX" : 2998, "minY" : 1138, "maxY" : 1183, "prop" : { "x" : 2956, "y" : 1153, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 2959, "y" : 1157 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2989, "y" : 1158 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2989, "y" : 1158 } } }, "connectors" : [ { "edgeId" : 86767, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2986, "y" : 1150 }, "to" : { "x" : 2998, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86770, "reactomeId" : 10315587, "displayName" : "IL35:(IL12RB2:p-JAK2) dimer:p-STAT4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3121, "y" : 1086 }, "minX" : 3057, "maxX" : 3191, "minY" : 1055, "maxY" : 1135, "prop" : { "x" : 3057, "y" : 1061, "width" : 128, "height" : 51 }, "textPosition" : { "x" : 3067, "y" : 1063 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3185, "y" : 1061 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3185, "y" : 1061 } } }, "connectors" : [ { "edgeId" : 86767, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3093, "y" : 1115 }, "to" : { "x" : 3068, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3090, "y" : 1122 }, "b" : { "x" : 3093, "y" : 1115 }, "c" : { "x" : 3085, "y" : 1116 }, "type" : "ARROW", "centre" : { "x" : 3085, "y" : 1116 } } }, { "edgeId" : 86771, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86772, "reactomeId" : 10313405, "displayName" : "phospho-STAT4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2837, "y" : 1293 }, "minX" : 2803, "maxX" : 2878, "minY" : 1236, "maxY" : 1304, "prop" : { "x" : 2803, "y" : 1282, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 2804, "y" : 1276 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2872, "y" : 1282 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2872, "y" : 1282 } } }, "connectors" : [ { "edgeId" : 86771, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2842, "y" : 1279 }, "to" : { "x" : 2868, "y" : 1236 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2842, "y" : 1271 }, "b" : { "x" : 2842, "y" : 1279 }, "c" : { "x" : 2849, "y" : 1275 }, "type" : "ARROW", "centre" : { "x" : 2849, "y" : 1275 } } } ] }, { "id" : 86774, "reactomeId" : 10315600, "displayName" : "IL35:IL27RA:JAK1:IL12RB2:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3757, "y" : 1085 }, "minX" : 3703, "maxX" : 3818, "minY" : 1054, "maxY" : 1141, "prop" : { "x" : 3703, "y" : 1060, "width" : 109, "height" : 51 }, "textPosition" : { "x" : 3712, "y" : 1062 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3812, "y" : 1060 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3812, "y" : 1060 } } }, "connectors" : [ { "edgeId" : 86773, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86775, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3739, "y" : 1114 }, "to" : { "x" : 3718, "y" : 1141 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86777, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3642, "y" : 1183 }, "minX" : 3623, "maxX" : 3663, "minY" : 1141, "maxY" : 1198, "prop" : { "x" : 3623, "y" : 1168, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 3626, "y" : 1172 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3657, "y" : 1173 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3657, "y" : 1173 } } }, "connectors" : [ { "edgeId" : 86775, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3646, "y" : 1165 }, "to" : { "x" : 3654, "y" : 1141 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3644, "y" : 1147 }, "b" : { "x" : 3656, "y" : 1159 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3650, "y" : 1153 } } }, "endShape" : { "a" : { "x" : 3644, "y" : 1157 }, "b" : { "x" : 3646, "y" : 1165 }, "c" : { "x" : 3652, "y" : 1160 }, "type" : "ARROW", "centre" : { "x" : 3652, "y" : 1160 } } } ] }, { "id" : 86776, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3749, "y" : 1184 }, "minX" : 3718, "maxX" : 3769, "minY" : 1141, "maxY" : 1199, "prop" : { "x" : 3730, "y" : 1169, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 3733, "y" : 1173 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3763, "y" : 1174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3763, "y" : 1174 } } }, "connectors" : [ { "edgeId" : 86775, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3738, "y" : 1166 }, "to" : { "x" : 3718, "y" : 1141 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3722, "y" : 1147 }, "b" : { "x" : 3734, "y" : 1159 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3728, "y" : 1153 } } } } ] }, { "id" : 86778, "reactomeId" : 10315604, "displayName" : "IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3610, "y" : 1090 }, "minX" : 3508, "maxX" : 3677, "minY" : 1060, "maxY" : 1341, "prop" : { "x" : 3549, "y" : 1066, "width" : 122, "height" : 48 }, "textPosition" : { "x" : 3558, "y" : 1065 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3671, "y" : 1066 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3671, "y" : 1066 } } }, "connectors" : [ { "edgeId" : 86786, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3600, "y" : 1117 }, "to" : { "x" : 3508, "y" : 1341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3601, "y" : 1125 }, "b" : { "x" : 3600, "y" : 1117 }, "c" : { "x" : 3594, "y" : 1122 }, "type" : "ARROW", "centre" : { "x" : 3594, "y" : 1122 } } }, { "edgeId" : 86775, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3630, "y" : 1117 }, "to" : { "x" : 3654, "y" : 1141 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3638, "y" : 1119 }, "b" : { "x" : 3630, "y" : 1117 }, "c" : { "x" : 3632, "y" : 1125 }, "type" : "ARROW", "centre" : { "x" : 3632, "y" : 1125 } } }, { "edgeId" : 86779, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3605, "y" : 1117 }, "to" : { "x" : 3583, "y" : 1247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86781, "reactomeId" : 10315610, "displayName" : "IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3421, "y" : 1090 }, "minX" : 3360, "maxX" : 3489, "minY" : 1059, "maxY" : 1138, "prop" : { "x" : 3360, "y" : 1065, "width" : 123, "height" : 50 }, "textPosition" : { "x" : 3362, "y" : 1066 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3483, "y" : 1065 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3483, "y" : 1065 } } }, "connectors" : [ { "edgeId" : 86779, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86782, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3401, "y" : 1118 }, "to" : { "x" : 3383, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86780, "reactomeId" : 10252138, "displayName" : "STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3647, "y" : 1293 }, "minX" : 3583, "maxX" : 3679, "minY" : 1247, "maxY" : 1304, "prop" : { "x" : 3621, "y" : 1283, "width" : 52, "height" : 21 }, "textPosition" : { "x" : 3624, "y" : 1283 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3673, "y" : 1283 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3673, "y" : 1283 } } }, "connectors" : [ { "edgeId" : 86779, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3632, "y" : 1280 }, "to" : { "x" : 3583, "y" : 1247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86783, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3408, "y" : 1186 }, "minX" : 3383, "maxX" : 3428, "minY" : 1138, "maxY" : 1201, "prop" : { "x" : 3389, "y" : 1171, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 3392, "y" : 1175 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3422, "y" : 1176 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3422, "y" : 1176 } } }, "connectors" : [ { "edgeId" : 86782, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3400, "y" : 1168 }, "to" : { "x" : 3383, "y" : 1138 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3385, "y" : 1147 }, "b" : { "x" : 3397, "y" : 1159 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3391, "y" : 1153 } } } } ] } ], "edges" : [ { "id" : 86658, "reactomeId" : 10313337, "displayName" : "EBI3:CANX binds IL27", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3675, "y" : 185 }, "minX" : 3669, "maxX" : 3681, "minY" : 152, "maxY" : 219, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3676, "y" : 152 }, "to" : { "x" : 3675, "y" : 185 } }, { "from" : { "x" : 3675, "y" : 185 }, "to" : { "x" : 3674, "y" : 219 } } ], "endShape" : { "a" : { "x" : 3670, "y" : 212 }, "b" : { "x" : 3674, "y" : 219 }, "c" : { "x" : 3678, "y" : 212 }, "type" : "ARROW", "centre" : { "x" : 3678, "y" : 212 } }, "reactionShape" : { "a" : { "x" : 3669, "y" : 179 }, "b" : { "x" : 3681, "y" : 191 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3675, "y" : 185 } }, "inputs" : [ { "id" : 86659, "points" : [ { "x" : 3718, "y" : 126 } ] }, { "id" : 86656, "points" : [ { "x" : 3561, "y" : 111 } ] } ], "outputs" : [ { "id" : 86660 } ] }, { "id" : 86786, "reactomeId" : 10315618, "displayName" : "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3274, "y" : 1337 }, "minX" : 3268, "maxX" : 3508, "minY" : 1122, "maxY" : 1343, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3268, "y" : 1122 }, "to" : { "x" : 3274, "y" : 1337 } }, { "from" : { "x" : 3274, "y" : 1337 }, "to" : { "x" : 3508, "y" : 1341 } } ], "reactionShape" : { "a" : { "x" : 3268, "y" : 1331 }, "b" : { "x" : 3280, "y" : 1343 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3274, "y" : 1337 } }, "inputs" : [ { "id" : 86785 } ], "outputs" : [ { "id" : 86759, "points" : [ { "x" : 3930, "y" : 1338 } ] }, { "id" : 86787, "points" : [ { "x" : 3603, "y" : 1442 } ] }, { "id" : 86778, "points" : [ { "x" : 3600, "y" : 1117 } ] } ] }, { "id" : 86661, "reactomeId" : 10258037, "displayName" : "IL12RB1:TYK2 binds IL12RB2:JAK2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1327, "y" : 1044 }, "minX" : 1292, "maxX" : 1359, "minY" : 1022, "maxY" : 1062, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1292, "y" : 1022 }, "to" : { "x" : 1327, "y" : 1044 } }, { "from" : { "x" : 1327, "y" : 1044 }, "to" : { "x" : 1359, "y" : 1062 } } ], "endShape" : { "a" : { "x" : 1351, "y" : 1062 }, "b" : { "x" : 1359, "y" : 1062 }, "c" : { "x" : 1355, "y" : 1055 }, "type" : "ARROW", "centre" : { "x" : 1355, "y" : 1055 } }, "reactionShape" : { "c" : { "x" : 1327, "y" : 1044 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1327, "y" : 1044 } }, "inputs" : [ { "id" : 86632, "points" : [ { "x" : 2478, "y" : 1071 }, { "x" : 2420, "y" : 1015 } ] }, { "id" : 86639, "points" : [ { "x" : 1286, "y" : 1068 } ] } ], "outputs" : [ { "id" : 86618 } ] }, { "id" : 86788, "reactomeId" : 10315598, "displayName" : "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 4943, "y" : 1228 }, "minX" : 4885, "maxX" : 4981, "minY" : 1123, "maxY" : 1234, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 4885, "y" : 1228 }, "to" : { "x" : 4943, "y" : 1228 } }, { "from" : { "x" : 4943, "y" : 1228 }, "to" : { "x" : 4981, "y" : 1123 } } ], "endShape" : { "a" : { "x" : 4982, "y" : 1131 }, "b" : { "x" : 4981, "y" : 1123 }, "c" : { "x" : 4975, "y" : 1128 }, "type" : "ARROW", "centre" : { "x" : 4975, "y" : 1128 } }, "reactionShape" : { "a" : { "x" : 4937, "y" : 1222 }, "b" : { "x" : 4949, "y" : 1234 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 4943, "y" : 1228 } }, "inputs" : [ { "id" : 86711, "points" : [ { "x" : 4850, "y" : 1127 } ] }, { "id" : 86752, "points" : [ { "x" : 4362, "y" : 1238 } ] }, { "id" : 86789, "points" : [ { "x" : 4853, "y" : 1289 } ] } ], "outputs" : [ { "id" : 86720 } ] }, { "id" : 86663, "reactomeId" : 10313253, "displayName" : "IL12A binds IL12B", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1359, "y" : 194 }, "minX" : 1353, "maxX" : 1365, "minY" : 160, "maxY" : 232, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1359, "y" : 160 }, "to" : { "x" : 1359, "y" : 194 } }, { "from" : { "x" : 1359, "y" : 194 }, "to" : { "x" : 1360, "y" : 232 } } ], "endShape" : { "a" : { "x" : 1356, "y" : 225 }, "b" : { "x" : 1360, "y" : 232 }, "c" : { "x" : 1364, "y" : 225 }, "type" : "ARROW", "centre" : { "x" : 1364, "y" : 225 } }, "reactionShape" : { "a" : { "x" : 1353, "y" : 188 }, "b" : { "x" : 1365, "y" : 200 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1359, "y" : 194 } }, "inputs" : [ { "id" : 86642, "points" : [ { "x" : 907, "y" : 95 } ] }, { "id" : 86655, "points" : [ { "x" : 1437, "y" : 98 } ] } ], "outputs" : [ { "id" : 86664 } ], "catalysts" : [ { "id" : 86645, "points" : [ { "x" : 594, "y" : 200 } ] } ] }, { "id" : 86791, "reactomeId" : 10313466, "displayName" : "p-STAT1 binds p-STAT3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 6585, "y" : 1467 }, "minX" : 6579, "maxX" : 6591, "minY" : 1432, "maxY" : 1503, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 6585, "y" : 1432 }, "to" : { "x" : 6585, "y" : 1467 } }, { "from" : { "x" : 6585, "y" : 1467 }, "to" : { "x" : 6587, "y" : 1503 } } ], "endShape" : { "a" : { "x" : 6583, "y" : 1496 }, "b" : { "x" : 6587, "y" : 1503 }, "c" : { "x" : 6591, "y" : 1496 }, "type" : "ARROW", "centre" : { "x" : 6591, "y" : 1496 } }, "reactionShape" : { "c" : { "x" : 6585, "y" : 1467 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 6585, "y" : 1467 } }, "inputs" : [ { "id" : 86693, "points" : [ { "x" : 6623, "y" : 1402 } ] }, { "id" : 86694, "points" : [ { "x" : 6549, "y" : 1407 } ] } ], "outputs" : [ { "id" : 86717 } ] }, { "id" : 86662, "reactomeId" : 10313370, "displayName" : "IL12B:IL12B translocates from ER lumen to the extracellular region", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 880, "y" : 557 }, "minX" : 874, "maxX" : 1539, "minY" : 354, "maxY" : 843, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 879, "y" : 354 }, "to" : { "x" : 880, "y" : 557 } }, { "from" : { "x" : 880, "y" : 557 }, "to" : { "x" : 1539, "y" : 843 } } ], "endShape" : { "a" : { "x" : 1531, "y" : 844 }, "b" : { "x" : 1539, "y" : 843 }, "c" : { "x" : 1534, "y" : 837 }, "type" : "ARROW", "centre" : { "x" : 1534, "y" : 837 } }, "reactionShape" : { "a" : { "x" : 874, "y" : 551 }, "b" : { "x" : 886, "y" : 563 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 880, "y" : 557 } }, "inputs" : [ { "id" : 86653 } ], "outputs" : [ { "id" : 86620 } ] }, { "id" : 86790, "reactomeId" : 10315596, "displayName" : "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 5035, "y" : 1296 }, "minX" : 4966, "maxX" : 5127, "minY" : 1122, "maxY" : 1302, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 5127, "y" : 1122 }, "to" : { "x" : 5035, "y" : 1296 } }, { "from" : { "x" : 5035, "y" : 1296 }, "to" : { "x" : 4966, "y" : 1295 } } ], "reactionShape" : { "a" : { "x" : 5029, "y" : 1290 }, "b" : { "x" : 5041, "y" : 1302 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 5035, "y" : 1296 } }, "inputs" : [ { "id" : 86723 } ], "outputs" : [ { "id" : 86711, "points" : [ { "x" : 4858, "y" : 1127 } ] }, { "id" : 86714, "points" : [ { "x" : 4896, "y" : 1366 } ] } ] }, { "id" : 86665, "reactomeId" : 10313355, "displayName" : "CANX binds EBI3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3524, "y" : 185 }, "minX" : 3518, "maxX" : 3530, "minY" : 121, "maxY" : 214, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3523, "y" : 214 }, "to" : { "x" : 3524, "y" : 185 } }, { "from" : { "x" : 3524, "y" : 185 }, "to" : { "x" : 3524, "y" : 121 } } ], "endShape" : { "a" : { "x" : 3528, "y" : 128 }, "b" : { "x" : 3524, "y" : 121 }, "c" : { "x" : 3520, "y" : 128 }, "type" : "ARROW", "centre" : { "x" : 3520, "y" : 128 } }, "reactionShape" : { "c" : { "x" : 3524, "y" : 185 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3524, "y" : 185 } }, "inputs" : [ { "id" : 86666, "points" : [ { "x" : 3543, "y" : 226 } ] }, { "id" : 86667, "points" : [ { "x" : 3502, "y" : 224 } ] } ], "outputs" : [ { "id" : 86656 } ] }, { "id" : 86792, "reactomeId" : 10313331, "displayName" : "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 6314, "y" : 1138 }, "minX" : 6282, "maxX" : 6346, "minY" : 1132, "maxY" : 1144, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 6282, "y" : 1139 }, "to" : { "x" : 6314, "y" : 1138 } }, { "from" : { "x" : 6314, "y" : 1138 }, "to" : { "x" : 6346, "y" : 1139 } } ], "reactionShape" : { "a" : { "x" : 6308, "y" : 1132 }, "b" : { "x" : 6320, "y" : 1144 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 6314, "y" : 1138 } }, "inputs" : [ { "id" : 86793, "points" : [ { "x" : 6267, "y" : 1159 } ], "stoichiometry" : 2 }, { "id" : 86688, "points" : [ { "x" : 6238, "y" : 1120 } ] } ], "outputs" : [ { "id" : 86794, "points" : [ { "x" : 6365, "y" : 1155 } ], "stoichiometry" : 2 }, { "id" : 86729, "points" : [ { "x" : 6377, "y" : 1122 } ] } ], "catalysts" : [ { "id" : 86688, "points" : [ { "x" : 6258, "y" : 1093 }, { "x" : 6312, "y" : 1094 } ] } ] }, { "id" : 86795, "reactomeId" : 10313255, "displayName" : "Interleukin-12 dissociates from Interleukin-12 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1478, "y" : 995 }, "minX" : 1415, "maxX" : 1511, "minY" : 989, "maxY" : 1059, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 1511, "y" : 1059 }, "to" : { "x" : 1478, "y" : 995 } }, { "from" : { "x" : 1478, "y" : 995 }, "to" : { "x" : 1415, "y" : 995 } } ], "reactionShape" : { "c" : { "x" : 1478, "y" : 995 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 1478, "y" : 995 } }, "inputs" : [ { "id" : 86619 } ], "outputs" : [ { "id" : 86618, "points" : [ { "x" : 1401, "y" : 1062 } ] }, { "id" : 86617, "points" : [ { "x" : 1379, "y" : 923 } ] } ] }, { "id" : 86796, "reactomeId" : 10313280, "displayName" : "Interleukin-27 dissociates from Interleukin-27 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 5871, "y" : 960 }, "minX" : 5670, "maxX" : 5940, "minY" : 954, "maxY" : 1057, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 5940, "y" : 1057 }, "to" : { "x" : 5871, "y" : 960 } }, { "from" : { "x" : 5871, "y" : 960 }, "to" : { "x" : 5670, "y" : 960 } } ], "reactionShape" : { "c" : { "x" : 5871, "y" : 960 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 5871, "y" : 960 } }, "inputs" : [ { "id" : 86629 } ], "outputs" : [ { "id" : 86628, "points" : [ { "x" : 5399, "y" : 1069 } ] }, { "id" : 86626, "points" : [ { "x" : 5547, "y" : 1080 } ] }, { "id" : 86627, "points" : [ { "x" : 5500, "y" : 939 } ] } ], "inhibitors" : [ { "id" : 86797, "points" : [ { "x" : 5876, "y" : 881 } ] } ] }, { "id" : 86668, "reactomeId" : 10313460, "displayName" : "IL27RA dimerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 5697, "y" : 1098 }, "minX" : 5658, "maxX" : 5723, "minY" : 1092, "maxY" : 1104, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 5658, "y" : 1098 }, "to" : { "x" : 5697, "y" : 1098 } }, { "from" : { "x" : 5697, "y" : 1098 }, "to" : { "x" : 5723, "y" : 1097 } } ], "endShape" : { "a" : { "x" : 5716, "y" : 1101 }, "b" : { "x" : 5723, "y" : 1097 }, "c" : { "x" : 5716, "y" : 1093 }, "type" : "ARROW", "centre" : { "x" : 5716, "y" : 1093 } }, "reactionShape" : { "c" : { "x" : 5697, "y" : 1098 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 5697, "y" : 1098 } }, "inputs" : [ { "id" : 86669, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86670 } ] }, { "id" : 86671, "reactomeId" : 10313426, "displayName" : "IL27 binds CRLF1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 5957, "y" : 339 }, "minX" : 5918, "maxX" : 5997, "minY" : 333, "maxY" : 345, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 5918, "y" : 339 }, "to" : { "x" : 5957, "y" : 339 } }, { "from" : { "x" : 5957, "y" : 339 }, "to" : { "x" : 5997, "y" : 338 } } ], "endShape" : { "a" : { "x" : 5990, "y" : 342 }, "b" : { "x" : 5997, "y" : 338 }, "c" : { "x" : 5990, "y" : 334 }, "type" : "ARROW", "centre" : { "x" : 5990, "y" : 334 } }, "reactionShape" : { "a" : { "x" : 5951, "y" : 333 }, "b" : { "x" : 5963, "y" : 345 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 5957, "y" : 339 } }, "inputs" : [ { "id" : 86672, "points" : [ { "x" : 5897, "y" : 330 } ] }, { "id" : 86673, "points" : [ { "x" : 5889, "y" : 360 } ] } ], "outputs" : [ { "id" : 86674 } ] }, { "id" : 86798, "reactomeId" : 10313456, "displayName" : "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1804, "y" : 1138 }, "minX" : 1769, "maxX" : 1832, "minY" : 1132, "maxY" : 1144, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1769, "y" : 1138 }, "to" : { "x" : 1804, "y" : 1138 } }, { "from" : { "x" : 1804, "y" : 1138 }, "to" : { "x" : 1832, "y" : 1139 } } ], "reactionShape" : { "a" : { "x" : 1798, "y" : 1132 }, "b" : { "x" : 1810, "y" : 1144 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1804, "y" : 1138 } }, "inputs" : [ { "id" : 86799, "points" : [ { "x" : 1748, "y" : 1163 } ] }, { "id" : 86680, "points" : [ { "x" : 1736, "y" : 1112 } ] } ], "outputs" : [ { "id" : 86726, "points" : [ { "x" : 1860, "y" : 1109 } ] }, { "id" : 86800, "points" : [ { "x" : 1842, "y" : 1160 } ] } ], "catalysts" : [ { "id" : 86680, "points" : [ { "x" : 1776, "y" : 1090 }, { "x" : 1800, "y" : 1094 } ] } ] }, { "id" : 86675, "reactomeId" : 10313447, "displayName" : "CRLF1:IL27 translocates to the extracellular region", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 6153, "y" : 337 }, "minX" : 6101, "maxX" : 6254, "minY" : 331, "maxY" : 343, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 6101, "y" : 337 }, "to" : { "x" : 6153, "y" : 337 } }, { "from" : { "x" : 6153, "y" : 337 }, "to" : { "x" : 6254, "y" : 336 } } ], "endShape" : { "a" : { "x" : 6247, "y" : 340 }, "b" : { "x" : 6254, "y" : 336 }, "c" : { "x" : 6247, "y" : 332 }, "type" : "ARROW", "centre" : { "x" : 6247, "y" : 332 } }, "reactionShape" : { "a" : { "x" : 6147, "y" : 331 }, "b" : { "x" : 6159, "y" : 343 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 6153, "y" : 337 } }, "inputs" : [ { "id" : 86674 } ], "outputs" : [ { "id" : 86676 } ] }, { "id" : 86677, "reactomeId" : 10313377, "displayName" : "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1614, "y" : 1133 }, "minX" : 1586, "maxX" : 1657, "minY" : 1127, "maxY" : 1139, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1586, "y" : 1134 }, "to" : { "x" : 1614, "y" : 1133 } }, { "from" : { "x" : 1614, "y" : 1133 }, "to" : { "x" : 1657, "y" : 1134 } } ], "reactionShape" : { "a" : { "x" : 1608, "y" : 1127 }, "b" : { "x" : 1620, "y" : 1139 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1614, "y" : 1133 } }, "inputs" : [ { "id" : 86678, "points" : [ { "x" : 1568, "y" : 1162 } ], "stoichiometry" : 2 }, { "id" : 86619, "points" : [ { "x" : 1556, "y" : 1115 } ] } ], "outputs" : [ { "id" : 86679, "points" : [ { "x" : 1674, "y" : 1163 } ], "stoichiometry" : 2 }, { "id" : 86680, "points" : [ { "x" : 1683, "y" : 1112 } ] } ], "catalysts" : [ { "id" : 86619, "points" : [ { "x" : 1590, "y" : 1091 }, { "x" : 1610, "y" : 1093 } ] } ] }, { "id" : 86681, "reactomeId" : 10313462, "displayName" : "p-Y693-STAT4 dimerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2282, "y" : 1454 }, "minX" : 2276, "maxX" : 2288, "minY" : 1404, "maxY" : 1501, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2282, "y" : 1404 }, "to" : { "x" : 2282, "y" : 1454 } }, { "from" : { "x" : 2282, "y" : 1454 }, "to" : { "x" : 2282, "y" : 1501 } } ], "endShape" : { "a" : { "x" : 2278, "y" : 1494 }, "b" : { "x" : 2282, "y" : 1501 }, "c" : { "x" : 2286, "y" : 1494 }, "type" : "ARROW", "centre" : { "x" : 2286, "y" : 1494 } }, "reactionShape" : { "c" : { "x" : 2282, "y" : 1454 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2282, "y" : 1454 } }, "inputs" : [ { "id" : 86682, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86683 } ] }, { "id" : 86684, "reactomeId" : 10313272, "displayName" : "p-Y693-STAT4 dimer translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2283, "y" : 1578 }, "minX" : 2277, "maxX" : 2289, "minY" : 1544, "maxY" : 1654, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2283, "y" : 1544 }, "to" : { "x" : 2283, "y" : 1578 } }, { "from" : { "x" : 2283, "y" : 1578 }, "to" : { "x" : 2283, "y" : 1654 } } ], "endShape" : { "a" : { "x" : 2279, "y" : 1647 }, "b" : { "x" : 2283, "y" : 1654 }, "c" : { "x" : 2287, "y" : 1647 }, "type" : "ARROW", "centre" : { "x" : 2287, "y" : 1647 } }, "reactionShape" : { "a" : { "x" : 2277, "y" : 1572 }, "b" : { "x" : 2289, "y" : 1584 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2283, "y" : 1578 } }, "inputs" : [ { "id" : 86683 } ], "outputs" : [ { "id" : 86685 } ] }, { "id" : 86686, "reactomeId" : 10313437, "displayName" : "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 6091, "y" : 1135 }, "minX" : 6061, "maxX" : 6118, "minY" : 1129, "maxY" : 1141, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 6061, "y" : 1135 }, "to" : { "x" : 6091, "y" : 1135 } }, { "from" : { "x" : 6091, "y" : 1135 }, "to" : { "x" : 6118, "y" : 1135 } } ], "reactionShape" : { "a" : { "x" : 6085, "y" : 1129 }, "b" : { "x" : 6097, "y" : 1141 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 6091, "y" : 1135 } }, "inputs" : [ { "id" : 86687, "points" : [ { "x" : 6039, "y" : 1158 } ], "stoichiometry" : 4 }, { "id" : 86629, "points" : [ { "x" : 6018, "y" : 1114 } ] } ], "outputs" : [ { "id" : 86688, "points" : [ { "x" : 6148, "y" : 1120 } ] }, { "id" : 86689, "points" : [ { "x" : 6146, "y" : 1156 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 86629, "points" : [ { "x" : 6018, "y" : 1093 }, { "x" : 6088, "y" : 1096 } ] } ] }, { "id" : 86690, "reactomeId" : 10313383, "displayName" : "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 6792, "y" : 1278 }, "minX" : 6600, "maxX" : 6798, "minY" : 1133, "maxY" : 1284, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 6790, "y" : 1133 }, "to" : { "x" : 6792, "y" : 1278 } }, { "from" : { "x" : 6792, "y" : 1278 }, "to" : { "x" : 6600, "y" : 1279 } } ], "reactionShape" : { "a" : { "x" : 6786, "y" : 1272 }, "b" : { "x" : 6798, "y" : 1284 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 6792, "y" : 1278 } }, "inputs" : [ { "id" : 86691 } ], "outputs" : [ { "id" : 86692, "points" : [ { "x" : 6590, "y" : 1130 } ] }, { "id" : 86693, "points" : [ { "x" : 6635, "y" : 1362 } ] }, { "id" : 86694, "points" : [ { "x" : 6538, "y" : 1363 } ] } ] }, { "id" : 86695, "reactomeId" : 10313418, "displayName" : "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 6693, "y" : 1160 }, "minX" : 6663, "maxX" : 6725, "minY" : 1154, "maxY" : 1166, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 6663, "y" : 1160 }, "to" : { "x" : 6693, "y" : 1160 } }, { "from" : { "x" : 6693, "y" : 1160 }, "to" : { "x" : 6725, "y" : 1159 } } ], "reactionShape" : { "a" : { "x" : 6687, "y" : 1154 }, "b" : { "x" : 6699, "y" : 1166 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 6693, "y" : 1160 } }, "inputs" : [ { "id" : 86696, "points" : [ { "x" : 6633, "y" : 1188 } ], "stoichiometry" : 2 }, { "id" : 86692, "points" : [ { "x" : 6628, "y" : 1130 } ] } ], "outputs" : [ { "id" : 86691, "points" : [ { "x" : 6749, "y" : 1133 } ] }, { "id" : 86697, "points" : [ { "x" : 6749, "y" : 1189 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 86692, "points" : [ { "x" : 6656, "y" : 1101 }, { "x" : 6696, "y" : 1111 } ] } ] }, { "id" : 86698, "reactomeId" : 10313302, "displayName" : "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1001, "y" : 1133 }, "minX" : 963, "maxX" : 1024, "minY" : 1127, "maxY" : 1139, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 963, "y" : 1134 }, "to" : { "x" : 1001, "y" : 1133 } }, { "from" : { "x" : 1001, "y" : 1133 }, "to" : { "x" : 1024, "y" : 1133 } } ], "reactionShape" : { "a" : { "x" : 995, "y" : 1127 }, "b" : { "x" : 1007, "y" : 1139 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1001, "y" : 1133 } }, "inputs" : [ { "id" : 86699, "points" : [ { "x" : 934, "y" : 1168 } ], "stoichiometry" : 2 }, { "id" : 86700, "points" : [ { "x" : 944, "y" : 1114 } ] } ], "outputs" : [ { "id" : 86701, "points" : [ { "x" : 1054, "y" : 1164 } ], "stoichiometry" : 2 }, { "id" : 86702, "points" : [ { "x" : 1033, "y" : 1126 } ] } ], "catalysts" : [ { "id" : 86700, "points" : [ { "x" : 985, "y" : 1079 }, { "x" : 1003, "y" : 1079 } ] } ] }, { "id" : 86703, "reactomeId" : 10313464, "displayName" : "p-Y705-STAT3 binds p-Y693-STAT4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1130, "y" : 1446 }, "minX" : 1124, "maxX" : 1136, "minY" : 1421, "maxY" : 1498, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1131, "y" : 1421 }, "to" : { "x" : 1130, "y" : 1446 } }, { "from" : { "x" : 1130, "y" : 1446 }, "to" : { "x" : 1133, "y" : 1498 } } ], "endShape" : { "a" : { "x" : 1129, "y" : 1491 }, "b" : { "x" : 1133, "y" : 1498 }, "c" : { "x" : 1137, "y" : 1491 }, "type" : "ARROW", "centre" : { "x" : 1137, "y" : 1491 } }, "reactionShape" : { "c" : { "x" : 1130, "y" : 1446 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1130, "y" : 1446 } }, "inputs" : [ { "id" : 86704, "points" : [ { "x" : 1081, "y" : 1382 } ] }, { "id" : 86705, "points" : [ { "x" : 1173, "y" : 1381 } ] } ], "outputs" : [ { "id" : 86706 } ] }, { "id" : 86707, "reactomeId" : 10313443, "displayName" : "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1132, "y" : 1569 }, "minX" : 1126, "maxX" : 1138, "minY" : 1540, "maxY" : 1635, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1133, "y" : 1540 }, "to" : { "x" : 1132, "y" : 1569 } }, { "from" : { "x" : 1132, "y" : 1569 }, "to" : { "x" : 1133, "y" : 1635 } } ], "endShape" : { "a" : { "x" : 1129, "y" : 1628 }, "b" : { "x" : 1133, "y" : 1635 }, "c" : { "x" : 1137, "y" : 1628 }, "type" : "ARROW", "centre" : { "x" : 1137, "y" : 1628 } }, "reactionShape" : { "a" : { "x" : 1126, "y" : 1563 }, "b" : { "x" : 1138, "y" : 1575 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1132, "y" : 1569 } }, "inputs" : [ { "id" : 86706 } ], "outputs" : [ { "id" : 86708 } ] }, { "id" : 86709, "reactomeId" : 10313366, "displayName" : "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 4757, "y" : 1152 }, "minX" : 4710, "maxX" : 4810, "minY" : 1146, "maxY" : 1158, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 4710, "y" : 1151 }, "to" : { "x" : 4757, "y" : 1152 } }, { "from" : { "x" : 4757, "y" : 1152 }, "to" : { "x" : 4810, "y" : 1151 } } ], "reactionShape" : { "a" : { "x" : 4751, "y" : 1146 }, "b" : { "x" : 4763, "y" : 1158 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 4757, "y" : 1152 } }, "inputs" : [ { "id" : 86710, "points" : [ { "x" : 4685, "y" : 1173 } ], "stoichiometry" : 2 }, { "id" : 86633, "points" : [ { "x" : 4693, "y" : 1126 } ] } ], "outputs" : [ { "id" : 86711, "points" : [ { "x" : 4827, "y" : 1127 } ] }, { "id" : 86712, "points" : [ { "x" : 4827, "y" : 1177 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 86633, "points" : [ { "x" : 4732, "y" : 1107 }, { "x" : 4754, "y" : 1112 } ] } ] }, { "id" : 86713, "reactomeId" : 10313434, "displayName" : "p-STAT1:p-STAT4 translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 4609, "y" : 1520 }, "minX" : 4396, "maxX" : 4840, "minY" : 1410, "maxY" : 1627, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 4840, "y" : 1410 }, "to" : { "x" : 4609, "y" : 1520 } }, { "from" : { "x" : 4609, "y" : 1520 }, "to" : { "x" : 4396, "y" : 1627 } } ], "endShape" : { "a" : { "x" : 4400, "y" : 1620 }, "b" : { "x" : 4396, "y" : 1627 }, "c" : { "x" : 4404, "y" : 1627 }, "type" : "ARROW", "centre" : { "x" : 4404, "y" : 1627 } }, "reactionShape" : { "a" : { "x" : 4603, "y" : 1514 }, "b" : { "x" : 4615, "y" : 1526 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 4609, "y" : 1520 } }, "inputs" : [ { "id" : 86714 } ], "outputs" : [ { "id" : 86715 } ] }, { "id" : 86716, "reactomeId" : 10313449, "displayName" : "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 6589, "y" : 1580 }, "minX" : 6583, "maxX" : 6595, "minY" : 1545, "maxY" : 1655, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 6589, "y" : 1545 }, "to" : { "x" : 6589, "y" : 1580 } }, { "from" : { "x" : 6589, "y" : 1580 }, "to" : { "x" : 6589, "y" : 1655 } } ], "endShape" : { "a" : { "x" : 6585, "y" : 1648 }, "b" : { "x" : 6589, "y" : 1655 }, "c" : { "x" : 6593, "y" : 1648 }, "type" : "ARROW", "centre" : { "x" : 6593, "y" : 1648 } }, "reactionShape" : { "a" : { "x" : 6583, "y" : 1574 }, "b" : { "x" : 6595, "y" : 1586 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 6589, "y" : 1580 } }, "inputs" : [ { "id" : 86717 } ], "outputs" : [ { "id" : 86718 } ] }, { "id" : 86719, "reactomeId" : 10313413, "displayName" : "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 5077, "y" : 1158 }, "minX" : 5030, "maxX" : 5119, "minY" : 1152, "maxY" : 1164, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 5030, "y" : 1158 }, "to" : { "x" : 5077, "y" : 1158 } }, { "from" : { "x" : 5077, "y" : 1158 }, "to" : { "x" : 5119, "y" : 1157 } } ], "reactionShape" : { "a" : { "x" : 5071, "y" : 1152 }, "b" : { "x" : 5083, "y" : 1164 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 5077, "y" : 1158 } }, "inputs" : [ { "id" : 86720, "points" : [ { "x" : 5009, "y" : 1123 } ] }, { "id" : 86721, "points" : [ { "x" : 5018, "y" : 1189 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86722, "points" : [ { "x" : 5131, "y" : 1179 } ], "stoichiometry" : 2 }, { "id" : 86723, "points" : [ { "x" : 5133, "y" : 1122 } ] } ], "catalysts" : [ { "id" : 86720, "points" : [ { "x" : 5052, "y" : 1113 }, { "x" : 5073, "y" : 1124 } ] } ] }, { "id" : 86724, "reactomeId" : 10313398, "displayName" : "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2011, "y" : 1139 }, "minX" : 1970, "maxX" : 2041, "minY" : 1111, "maxY" : 1145, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1970, "y" : 1138 }, "to" : { "x" : 2011, "y" : 1139 } }, { "from" : { "x" : 2011, "y" : 1139 }, "to" : { "x" : 2041, "y" : 1111 } } ], "endShape" : { "a" : { "x" : 2039, "y" : 1119 }, "b" : { "x" : 2041, "y" : 1111 }, "c" : { "x" : 2033, "y" : 1113 }, "type" : "ARROW", "centre" : { "x" : 2033, "y" : 1113 } }, "reactionShape" : { "c" : { "x" : 2011, "y" : 1139 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2011, "y" : 1139 } }, "inputs" : [ { "id" : 86725, "points" : [ { "x" : 1949, "y" : 1167 } ], "stoichiometry" : 2 }, { "id" : 86726, "points" : [ { "x" : 1930, "y" : 1109 } ] } ], "outputs" : [ { "id" : 86727 } ] }, { "id" : 86728, "reactomeId" : 10313428, "displayName" : "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 6529, "y" : 1162 }, "minX" : 6484, "maxX" : 6556, "minY" : 1130, "maxY" : 1168, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 6484, "y" : 1163 }, "to" : { "x" : 6529, "y" : 1162 } }, { "from" : { "x" : 6529, "y" : 1162 }, "to" : { "x" : 6556, "y" : 1130 } } ], "endShape" : { "a" : { "x" : 6555, "y" : 1138 }, "b" : { "x" : 6556, "y" : 1130 }, "c" : { "x" : 6548, "y" : 1133 }, "type" : "ARROW", "centre" : { "x" : 6548, "y" : 1133 } }, "reactionShape" : { "a" : { "x" : 6523, "y" : 1156 }, "b" : { "x" : 6535, "y" : 1168 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 6529, "y" : 1162 } }, "inputs" : [ { "id" : 86729, "points" : [ { "x" : 6451, "y" : 1122 } ] }, { "id" : 86730, "points" : [ { "x" : 6476, "y" : 1206 } ] }, { "id" : 86731, "points" : [ { "x" : 6467, "y" : 1168 } ] } ], "outputs" : [ { "id" : 86692 } ] }, { "id" : 86733, "reactomeId" : 10313357, "displayName" : "CANX dissociates from IL27:EBI3", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3628, "y" : 302 }, "minX" : 3572, "maxX" : 3660, "minY" : 262, "maxY" : 308, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3660, "y" : 262 }, "to" : { "x" : 3628, "y" : 302 } }, { "from" : { "x" : 3628, "y" : 302 }, "to" : { "x" : 3572, "y" : 304 } } ], "reactionShape" : { "a" : { "x" : 3622, "y" : 296 }, "b" : { "x" : 3634, "y" : 308 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3628, "y" : 302 } }, "inputs" : [ { "id" : 86660 } ], "outputs" : [ { "id" : 86635, "points" : [ { "x" : 3574, "y" : 332 } ] }, { "id" : 86667, "points" : [ { "x" : 3500, "y" : 252 } ] } ] }, { "id" : 86732, "reactomeId" : 10313451, "displayName" : "CANX dissociates from IL12A:EBI3", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3371, "y" : 310 }, "minX" : 3335, "maxX" : 3444, "minY" : 260, "maxY" : 316, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3335, "y" : 260 }, "to" : { "x" : 3371, "y" : 310 } }, { "from" : { "x" : 3371, "y" : 310 }, "to" : { "x" : 3444, "y" : 311 } } ], "reactionShape" : { "a" : { "x" : 3365, "y" : 304 }, "b" : { "x" : 3377, "y" : 316 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3371, "y" : 310 } }, "inputs" : [ { "id" : 86657 } ], "outputs" : [ { "id" : 86623, "points" : [ { "x" : 3475, "y" : 333 } ] }, { "id" : 86667, "points" : [ { "x" : 3479, "y" : 252 } ] } ] }, { "id" : 86734, "reactomeId" : 10314500, "displayName" : "STAT4 binds p-Y-IL23R in IL23:IL23 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 849, "y" : 1130 }, "minX" : 811, "maxX" : 875, "minY" : 1114, "maxY" : 1136, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 811, "y" : 1131 }, "to" : { "x" : 849, "y" : 1130 } }, { "from" : { "x" : 849, "y" : 1130 }, "to" : { "x" : 875, "y" : 1114 } } ], "endShape" : { "a" : { "x" : 871, "y" : 1121 }, "b" : { "x" : 875, "y" : 1114 }, "c" : { "x" : 867, "y" : 1114 }, "type" : "ARROW", "centre" : { "x" : 867, "y" : 1114 } }, "reactionShape" : { "a" : { "x" : 843, "y" : 1124 }, "b" : { "x" : 855, "y" : 1136 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 849, "y" : 1130 } }, "inputs" : [ { "id" : 86735, "points" : [ { "x" : 790, "y" : 1117 } ] }, { "id" : 86736, "points" : [ { "x" : 786, "y" : 1175 } ] } ], "outputs" : [ { "id" : 86700 } ] }, { "id" : 86737, "reactomeId" : 10314506, "displayName" : "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1126, "y" : 1175 }, "minX" : 1111, "maxX" : 1132, "minY" : 1131, "maxY" : 1238, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1111, "y" : 1131 }, "to" : { "x" : 1126, "y" : 1175 } }, { "from" : { "x" : 1126, "y" : 1175 }, "to" : { "x" : 1126, "y" : 1238 } } ], "reactionShape" : { "a" : { "x" : 1120, "y" : 1169 }, "b" : { "x" : 1132, "y" : 1181 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1126, "y" : 1175 } }, "inputs" : [ { "id" : 86702 } ], "outputs" : [ { "id" : 86738, "points" : [ { "x" : 609, "y" : 1119 }, { "x" : 710, "y" : 1236 } ] }, { "id" : 86704, "points" : [ { "x" : 1071, "y" : 1347 } ] }, { "id" : 86705, "points" : [ { "x" : 1181, "y" : 1344 } ] } ] }, { "id" : 86739, "reactomeId" : 10314504, "displayName" : "p-Y693-STAT4 dissociates after IL12:IL12R interaction", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2284, "y" : 1286 }, "minX" : 2278, "maxX" : 2290, "minY" : 1115, "maxY" : 1366, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2283, "y" : 1115 }, "to" : { "x" : 2284, "y" : 1286 } }, { "from" : { "x" : 2284, "y" : 1286 }, "to" : { "x" : 2283, "y" : 1366 } } ], "endShape" : { "a" : { "x" : 2279, "y" : 1359 }, "b" : { "x" : 2283, "y" : 1366 }, "c" : { "x" : 2287, "y" : 1359 }, "type" : "ARROW", "centre" : { "x" : 2287, "y" : 1359 } }, "reactionShape" : { "a" : { "x" : 2278, "y" : 1280 }, "b" : { "x" : 2290, "y" : 1292 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2284, "y" : 1286 } }, "inputs" : [ { "id" : 86740 } ], "outputs" : [ { "id" : 86682, "stoichiometry" : 2 } ] }, { "id" : 86741, "reactomeId" : 10315101, "displayName" : "IL12 bound to IL12R internalises", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1522, "y" : 1172 }, "minX" : 1516, "maxX" : 1528, "minY" : 1115, "maxY" : 1285, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1523, "y" : 1115 }, "to" : { "x" : 1522, "y" : 1172 } }, { "from" : { "x" : 1522, "y" : 1172 }, "to" : { "x" : 1522, "y" : 1285 } } ], "reactionShape" : { "a" : { "x" : 1516, "y" : 1166 }, "b" : { "x" : 1528, "y" : 1178 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1522, "y" : 1172 } }, "inputs" : [ { "id" : 86619 } ] }, { "id" : 86742, "reactomeId" : 10315559, "displayName" : "IL35 binds IL12RB2:IL12RB2 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2625, "y" : 1023 }, "minX" : 2577, "maxX" : 2652, "minY" : 1017, "maxY" : 1075, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2577, "y" : 1024 }, "to" : { "x" : 2625, "y" : 1023 } }, { "from" : { "x" : 2625, "y" : 1023 }, "to" : { "x" : 2652, "y" : 1075 } } ], "endShape" : { "a" : { "x" : 2645, "y" : 1071 }, "b" : { "x" : 2652, "y" : 1075 }, "c" : { "x" : 2652, "y" : 1067 }, "type" : "ARROW", "centre" : { "x" : 2652, "y" : 1067 } }, "reactionShape" : { "a" : { "x" : 2619, "y" : 1017 }, "b" : { "x" : 2631, "y" : 1029 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2625, "y" : 1023 } }, "inputs" : [ { "id" : 86632, "points" : [ { "x" : 2518, "y" : 1071 } ], "stoichiometry" : 2 }, { "id" : 86624, "points" : [ { "x" : 2491, "y" : 831 } ] } ], "outputs" : [ { "id" : 86743 } ] }, { "id" : 86744, "reactomeId" : 10315555, "displayName" : "IL35 binds IL6ST:IL6ST receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 4489, "y" : 1035 }, "minX" : 4348, "maxX" : 4540, "minY" : 914, "maxY" : 1077, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 4348, "y" : 914 }, "to" : { "x" : 4489, "y" : 1035 } }, { "from" : { "x" : 4489, "y" : 1035 }, "to" : { "x" : 4540, "y" : 1077 } } ], "endShape" : { "a" : { "x" : 4532, "y" : 1076 }, "b" : { "x" : 4540, "y" : 1077 }, "c" : { "x" : 4537, "y" : 1070 }, "type" : "ARROW", "centre" : { "x" : 4537, "y" : 1070 } }, "reactionShape" : { "a" : { "x" : 4483, "y" : 1029 }, "b" : { "x" : 4495, "y" : 1041 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 4489, "y" : 1035 } }, "inputs" : [ { "id" : 86628, "points" : [ { "x" : 5320, "y" : 1069 }, { "x" : 5031, "y" : 924 } ], "stoichiometry" : 2 }, { "id" : 86624, "points" : [ { "x" : 2518, "y" : 816 } ] } ], "outputs" : [ { "id" : 86745 } ] }, { "id" : 86616, "reactomeId" : 10258033, "displayName" : "Interleukin-12 binds Interleukin-12 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1503, "y" : 973 }, "minX" : 1442, "maxX" : 1519, "minY" : 967, "maxY" : 1059, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1442, "y" : 972 }, "to" : { "x" : 1503, "y" : 973 } }, { "from" : { "x" : 1503, "y" : 973 }, "to" : { "x" : 1519, "y" : 1059 } } ], "endShape" : { "a" : { "x" : 1514, "y" : 1053 }, "b" : { "x" : 1519, "y" : 1059 }, "c" : { "x" : 1522, "y" : 1051 }, "type" : "ARROW", "centre" : { "x" : 1522, "y" : 1051 } }, "reactionShape" : { "c" : { "x" : 1503, "y" : 973 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1503, "y" : 973 } }, "inputs" : [ { "id" : 86617, "points" : [ { "x" : 1389, "y" : 923 } ] }, { "id" : 86618, "points" : [ { "x" : 1406, "y" : 1062 } ] } ], "outputs" : [ { "id" : 86619 } ], "inhibitors" : [ { "id" : 86620, "points" : [ { "x" : 1559, "y" : 871 } ] }, { "id" : 86621, "points" : [ { "x" : 1626, "y" : 868 } ] } ] }, { "id" : 86746, "reactomeId" : 10315567, "displayName" : "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 4484, "y" : 1146 }, "minX" : 4441, "maxX" : 4536, "minY" : 1140, "maxY" : 1152, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 4536, "y" : 1146 }, "to" : { "x" : 4484, "y" : 1146 } }, { "from" : { "x" : 4484, "y" : 1146 }, "to" : { "x" : 4441, "y" : 1147 } } ], "reactionShape" : { "a" : { "x" : 4478, "y" : 1140 }, "b" : { "x" : 4490, "y" : 1152 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 4484, "y" : 1146 } }, "inputs" : [ { "id" : 86747, "points" : [ { "x" : 4557, "y" : 1166 } ], "stoichiometry" : 2 }, { "id" : 86745, "points" : [ { "x" : 4551, "y" : 1119 } ] } ], "outputs" : [ { "id" : 86748, "points" : [ { "x" : 4422, "y" : 1176 } ], "stoichiometry" : 2 }, { "id" : 86749, "points" : [ { "x" : 4428, "y" : 1129 } ] } ] }, { "id" : 86750, "reactomeId" : 10315577, "displayName" : "STAT1 associates with IL6ST:IL6ST", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 4178, "y" : 1169 }, "minX" : 4078, "maxX" : 4253, "minY" : 1117, "maxY" : 1175, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 4253, "y" : 1169 }, "to" : { "x" : 4178, "y" : 1169 } }, { "from" : { "x" : 4178, "y" : 1169 }, "to" : { "x" : 4078, "y" : 1117 } } ], "endShape" : { "a" : { "x" : 4086, "y" : 1117 }, "b" : { "x" : 4078, "y" : 1117 }, "c" : { "x" : 4082, "y" : 1124 }, "type" : "ARROW", "centre" : { "x" : 4082, "y" : 1124 } }, "reactionShape" : { "a" : { "x" : 4172, "y" : 1163 }, "b" : { "x" : 4184, "y" : 1175 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 4178, "y" : 1169 } }, "inputs" : [ { "id" : 86751, "points" : [ { "x" : 4262, "y" : 1114 } ] }, { "id" : 86752, "points" : [ { "x" : 4316, "y" : 1226 } ] } ], "outputs" : [ { "id" : 86753 } ] }, { "id" : 86622, "reactomeId" : 10258105, "displayName" : "Interleukin-35 translocates from the ER lumen to the extracellular region", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3050, "y" : 577 }, "minX" : 2515, "maxX" : 3468, "minY" : 361, "maxY" : 800, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3468, "y" : 361 }, "to" : { "x" : 3050, "y" : 577 } }, { "from" : { "x" : 3050, "y" : 577 }, "to" : { "x" : 2515, "y" : 800 } } ], "endShape" : { "a" : { "x" : 2520, "y" : 794 }, "b" : { "x" : 2515, "y" : 800 }, "c" : { "x" : 2523, "y" : 801 }, "type" : "ARROW", "centre" : { "x" : 2523, "y" : 801 } }, "reactionShape" : { "a" : { "x" : 3044, "y" : 571 }, "b" : { "x" : 3056, "y" : 583 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3050, "y" : 577 } }, "inputs" : [ { "id" : 86623 } ], "outputs" : [ { "id" : 86624 } ] }, { "id" : 86625, "reactomeId" : 10258075, "displayName" : "Interleukin-27 binds Interleukin-27 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 5844, "y" : 990 }, "minX" : 5672, "maxX" : 5925, "minY" : 984, "maxY" : 1057, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 5672, "y" : 991 }, "to" : { "x" : 5844, "y" : 990 } }, { "from" : { "x" : 5844, "y" : 990 }, "to" : { "x" : 5925, "y" : 1057 } } ], "endShape" : { "a" : { "x" : 5917, "y" : 1056 }, "b" : { "x" : 5925, "y" : 1057 }, "c" : { "x" : 5922, "y" : 1050 }, "type" : "ARROW", "centre" : { "x" : 5922, "y" : 1050 } }, "reactionShape" : { "c" : { "x" : 5844, "y" : 990 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 5844, "y" : 990 } }, "inputs" : [ { "id" : 86626, "points" : [ { "x" : 5551, "y" : 1080 } ] }, { "id" : 86627, "points" : [ { "x" : 5500, "y" : 944 } ] }, { "id" : 86628, "points" : [ { "x" : 5414, "y" : 1072 } ] } ], "outputs" : [ { "id" : 86629 } ], "inhibitors" : [ { "id" : 86630, "points" : [ { "x" : 5808, "y" : 1011 } ] } ] }, { "id" : 86754, "reactomeId" : 10315575, "displayName" : "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3956, "y" : 1133 }, "minX" : 3931, "maxX" : 3996, "minY" : 1127, "maxY" : 1139, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3996, "y" : 1134 }, "to" : { "x" : 3956, "y" : 1133 } }, { "from" : { "x" : 3956, "y" : 1133 }, "to" : { "x" : 3931, "y" : 1133 } } ], "reactionShape" : { "a" : { "x" : 3950, "y" : 1127 }, "b" : { "x" : 3962, "y" : 1139 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3956, "y" : 1133 } }, "inputs" : [ { "id" : 86753, "points" : [ { "x" : 4012, "y" : 1117 } ] }, { "id" : 86755, "points" : [ { "x" : 4022, "y" : 1151 } ] } ], "outputs" : [ { "id" : 86756, "points" : [ { "x" : 3910, "y" : 1148 } ] }, { "id" : 86757, "points" : [ { "x" : 3914, "y" : 1116 } ] } ] }, { "id" : 86631, "reactomeId" : 10304841, "displayName" : "IL35 binds IL-12RB2:IL6ST receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 4577, "y" : 1014 }, "minX" : 4123, "maxX" : 4650, "minY" : 738, "maxY" : 1072, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 4123, "y" : 738 }, "to" : { "x" : 4577, "y" : 1014 } }, { "from" : { "x" : 4577, "y" : 1014 }, "to" : { "x" : 4650, "y" : 1072 } } ], "endShape" : { "a" : { "x" : 4642, "y" : 1071 }, "b" : { "x" : 4650, "y" : 1072 }, "c" : { "x" : 4647, "y" : 1065 }, "type" : "ARROW", "centre" : { "x" : 4647, "y" : 1065 } }, "reactionShape" : { "a" : { "x" : 4571, "y" : 1008 }, "b" : { "x" : 4583, "y" : 1020 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 4577, "y" : 1014 } }, "inputs" : [ { "id" : 86628, "points" : [ { "x" : 5298, "y" : 1074 } ] }, { "id" : 86632, "points" : [ { "x" : 2543, "y" : 1082 } ] }, { "id" : 86624, "points" : [ { "x" : 2518, "y" : 813 } ] } ], "outputs" : [ { "id" : 86633 } ] }, { "id" : 86758, "reactomeId" : 10315579, "displayName" : "p-STAT1 dissociates from IL6ST:IL6ST", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3957, "y" : 1169 }, "minX" : 3912, "maxX" : 3998, "minY" : 1116, "maxY" : 1205, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3912, "y" : 1116 }, "to" : { "x" : 3957, "y" : 1169 } }, { "from" : { "x" : 3957, "y" : 1169 }, "to" : { "x" : 3998, "y" : 1205 } } ], "reactionShape" : { "a" : { "x" : 3951, "y" : 1163 }, "b" : { "x" : 3963, "y" : 1175 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3957, "y" : 1169 } }, "inputs" : [ { "id" : 86757 } ], "outputs" : [ { "id" : 86759, "points" : [ { "x" : 3970, "y" : 1322 } ] }, { "id" : 86751, "points" : [ { "x" : 4220, "y" : 1114 } ] } ] }, { "id" : 86760, "reactomeId" : 10315583, "displayName" : "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2715, "y" : 1147 }, "minX" : 2688, "maxX" : 2742, "minY" : 1141, "maxY" : 1153, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2688, "y" : 1147 }, "to" : { "x" : 2715, "y" : 1147 } }, { "from" : { "x" : 2715, "y" : 1147 }, "to" : { "x" : 2742, "y" : 1147 } } ], "reactionShape" : { "a" : { "x" : 2709, "y" : 1141 }, "b" : { "x" : 2721, "y" : 1153 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2715, "y" : 1147 } }, "inputs" : [ { "id" : 86743, "points" : [ { "x" : 2671, "y" : 1117 } ] }, { "id" : 86761, "points" : [ { "x" : 2666, "y" : 1171 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86762, "points" : [ { "x" : 2753, "y" : 1169 } ], "stoichiometry" : 2 }, { "id" : 86763, "points" : [ { "x" : 2780, "y" : 1115 } ] } ] }, { "id" : 86634, "reactomeId" : 10258055, "displayName" : "Interleukin-27 translocates from the ER lumen to the extracellular region", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 4296, "y" : 562 }, "minX" : 3611, "maxX" : 5421, "minY" : 355, "maxY" : 920, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3611, "y" : 355 }, "to" : { "x" : 4296, "y" : 562 } }, { "from" : { "x" : 4296, "y" : 562 }, "to" : { "x" : 5421, "y" : 920 } } ], "endShape" : { "a" : { "x" : 5413, "y" : 922 }, "b" : { "x" : 5421, "y" : 920 }, "c" : { "x" : 5416, "y" : 914 }, "type" : "ARROW", "centre" : { "x" : 5416, "y" : 914 } }, "reactionShape" : { "a" : { "x" : 4290, "y" : 556 }, "b" : { "x" : 4302, "y" : 568 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 4296, "y" : 562 } }, "inputs" : [ { "id" : 86635 } ], "outputs" : [ { "id" : 86627 } ] }, { "id" : 86636, "reactomeId" : 10258013, "displayName" : "Interleukin-23 binds interleukin-23 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 233, "y" : 1030 }, "minX" : 227, "maxX" : 239, "minY" : 996, "maxY" : 1055, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 233, "y" : 996 }, "to" : { "x" : 233, "y" : 1030 } }, { "from" : { "x" : 233, "y" : 1030 }, "to" : { "x" : 230, "y" : 1055 } } ], "endShape" : { "a" : { "x" : 227, "y" : 1048 }, "b" : { "x" : 230, "y" : 1055 }, "c" : { "x" : 235, "y" : 1049 }, "type" : "ARROW", "centre" : { "x" : 235, "y" : 1049 } }, "reactionShape" : { "a" : { "x" : 227, "y" : 1024 }, "b" : { "x" : 239, "y" : 1036 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 233, "y" : 1030 } }, "inputs" : [ { "id" : 86637, "points" : [ { "x" : 233, "y" : 952 } ] }, { "id" : 86638, "points" : [ { "x" : 144, "y" : 1071 } ] }, { "id" : 86639, "points" : [ { "x" : 1266, "y" : 1068 }, { "x" : 1180, "y" : 992 } ] } ], "outputs" : [ { "id" : 86640 } ] }, { "id" : 86764, "reactomeId" : 10315592, "displayName" : "STAT4 binds IL12RB2:IL12RB2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2901, "y" : 1128 }, "minX" : 2870, "maxX" : 2921, "minY" : 1115, "maxY" : 1134, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2870, "y" : 1128 }, "to" : { "x" : 2901, "y" : 1128 } }, { "from" : { "x" : 2901, "y" : 1128 }, "to" : { "x" : 2921, "y" : 1115 } } ], "endShape" : { "a" : { "x" : 2917, "y" : 1122 }, "b" : { "x" : 2921, "y" : 1115 }, "c" : { "x" : 2913, "y" : 1115 }, "type" : "ARROW", "centre" : { "x" : 2913, "y" : 1115 } }, "reactionShape" : { "a" : { "x" : 2895, "y" : 1122 }, "b" : { "x" : 2907, "y" : 1134 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2901, "y" : 1128 } }, "inputs" : [ { "id" : 86763, "points" : [ { "x" : 2837, "y" : 1115 } ] }, { "id" : 86765, "points" : [ { "x" : 2876, "y" : 1147 } ] } ], "outputs" : [ { "id" : 86766 } ] }, { "id" : 86767, "reactomeId" : 10315590, "displayName" : "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3035, "y" : 1136 }, "minX" : 2998, "maxX" : 3068, "minY" : 1130, "maxY" : 1142, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2998, "y" : 1138 }, "to" : { "x" : 3035, "y" : 1136 } }, { "from" : { "x" : 3035, "y" : 1136 }, "to" : { "x" : 3068, "y" : 1135 } } ], "reactionShape" : { "a" : { "x" : 3029, "y" : 1130 }, "b" : { "x" : 3041, "y" : 1142 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3035, "y" : 1136 } }, "inputs" : [ { "id" : 86766, "points" : [ { "x" : 2975, "y" : 1115 } ] }, { "id" : 86768, "points" : [ { "x" : 2986, "y" : 1150 } ] } ], "outputs" : [ { "id" : 86769, "points" : [ { "x" : 3078, "y" : 1153 } ] }, { "id" : 86770, "points" : [ { "x" : 3093, "y" : 1115 } ] } ], "catalysts" : [ { "id" : 86766, "points" : [ { "x" : 3013, "y" : 1099 }, { "x" : 3031, "y" : 1104 } ] } ] }, { "id" : 86641, "reactomeId" : 10313278, "displayName" : "IL12B binds IL23A", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 226, "y" : 188 }, "minX" : 220, "maxX" : 232, "minY" : 144, "maxY" : 246, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 226, "y" : 144 }, "to" : { "x" : 226, "y" : 188 } }, { "from" : { "x" : 226, "y" : 188 }, "to" : { "x" : 226, "y" : 246 } } ], "endShape" : { "a" : { "x" : 222, "y" : 239 }, "b" : { "x" : 226, "y" : 246 }, "c" : { "x" : 230, "y" : 239 }, "type" : "ARROW", "centre" : { "x" : 230, "y" : 239 } }, "reactionShape" : { "a" : { "x" : 220, "y" : 182 }, "b" : { "x" : 232, "y" : 194 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 226, "y" : 188 } }, "inputs" : [ { "id" : 86642, "points" : [ { "x" : 857, "y" : 93 } ] }, { "id" : 86643, "points" : [ { "x" : 193, "y" : 119 } ] } ], "outputs" : [ { "id" : 86644 } ], "catalysts" : [ { "id" : 86645, "points" : [ { "x" : 540, "y" : 200 } ] } ] }, { "id" : 86771, "reactomeId" : 10315594, "displayName" : "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3113, "y" : 1235 }, "minX" : 2868, "maxX" : 3119, "minY" : 1115, "maxY" : 1241, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3119, "y" : 1115 }, "to" : { "x" : 3113, "y" : 1235 } }, { "from" : { "x" : 3113, "y" : 1235 }, "to" : { "x" : 2868, "y" : 1236 } } ], "reactionShape" : { "a" : { "x" : 3107, "y" : 1229 }, "b" : { "x" : 3119, "y" : 1241 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3113, "y" : 1235 } }, "inputs" : [ { "id" : 86770 } ], "outputs" : [ { "id" : 86772, "points" : [ { "x" : 2842, "y" : 1279 } ] }, { "id" : 86763, "points" : [ { "x" : 2809, "y" : 1115 } ] } ] }, { "id" : 86773, "reactomeId" : 10315602, "displayName" : "IL35 binds IL27RA:IL12RB2 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3661, "y" : 990 }, "minX" : 3603, "maxX" : 3731, "minY" : 941, "maxY" : 1057, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3603, "y" : 941 }, "to" : { "x" : 3661, "y" : 990 } }, { "from" : { "x" : 3661, "y" : 990 }, "to" : { "x" : 3731, "y" : 1057 } } ], "endShape" : { "a" : { "x" : 3723, "y" : 1055 }, "b" : { "x" : 3731, "y" : 1057 }, "c" : { "x" : 3729, "y" : 1049 }, "type" : "ARROW", "centre" : { "x" : 3729, "y" : 1049 } }, "reactionShape" : { "a" : { "x" : 3655, "y" : 984 }, "b" : { "x" : 3667, "y" : 996 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3661, "y" : 990 } }, "inputs" : [ { "id" : 86626, "points" : [ { "x" : 5503, "y" : 1080 }, { "x" : 5225, "y" : 963 } ] }, { "id" : 86624, "points" : [ { "x" : 2518, "y" : 818 } ] }, { "id" : 86632, "points" : [ { "x" : 2543, "y" : 1086 } ] } ], "outputs" : [ { "id" : 86774 } ] }, { "id" : 86775, "reactomeId" : 10315606, "displayName" : "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3688, "y" : 1142 }, "minX" : 3654, "maxX" : 3718, "minY" : 1136, "maxY" : 1148, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3718, "y" : 1141 }, "to" : { "x" : 3688, "y" : 1142 } }, { "from" : { "x" : 3688, "y" : 1142 }, "to" : { "x" : 3654, "y" : 1141 } } ], "reactionShape" : { "a" : { "x" : 3682, "y" : 1136 }, "b" : { "x" : 3694, "y" : 1148 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3688, "y" : 1142 } }, "inputs" : [ { "id" : 86774, "points" : [ { "x" : 3739, "y" : 1114 } ] }, { "id" : 86776, "points" : [ { "x" : 3738, "y" : 1166 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86777, "points" : [ { "x" : 3646, "y" : 1165 } ], "stoichiometry" : 2 }, { "id" : 86778, "points" : [ { "x" : 3630, "y" : 1117 } ] } ] }, { "id" : 86646, "reactomeId" : 10313347, "displayName" : "IL12A:IL12B translocates from late endosome lumen to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1362, "y" : 582 }, "minX" : 1356, "maxX" : 1370, "minY" : 530, "maxY" : 880, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1362, "y" : 530 }, "to" : { "x" : 1362, "y" : 582 } }, { "from" : { "x" : 1362, "y" : 582 }, "to" : { "x" : 1370, "y" : 880 } } ], "endShape" : { "a" : { "x" : 1366, "y" : 873 }, "b" : { "x" : 1370, "y" : 880 }, "c" : { "x" : 1374, "y" : 873 }, "type" : "ARROW", "centre" : { "x" : 1374, "y" : 873 } }, "reactionShape" : { "a" : { "x" : 1356, "y" : 576 }, "b" : { "x" : 1368, "y" : 588 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1362, "y" : 582 } }, "inputs" : [ { "id" : 86647 } ], "outputs" : [ { "id" : 86617 } ], "inhibitors" : [ { "id" : 86648, "points" : [ { "x" : 1461, "y" : 485 }, { "x" : 1429, "y" : 582 } ] } ], "activators" : [ { "id" : 86648, "points" : [ { "x" : 1454, "y" : 485 } ] } ] }, { "id" : 86649, "reactomeId" : 10313453, "displayName" : "IL12B:IL23A translocates from ER lumen to extracellular space", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 227, "y" : 604 }, "minX" : 221, "maxX" : 233, "minY" : 287, "maxY" : 911, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 226, "y" : 287 }, "to" : { "x" : 227, "y" : 604 } }, { "from" : { "x" : 227, "y" : 604 }, "to" : { "x" : 232, "y" : 911 } } ], "endShape" : { "a" : { "x" : 228, "y" : 904 }, "b" : { "x" : 232, "y" : 911 }, "c" : { "x" : 236, "y" : 904 }, "type" : "ARROW", "centre" : { "x" : 236, "y" : 904 } }, "reactionShape" : { "a" : { "x" : 221, "y" : 598 }, "b" : { "x" : 233, "y" : 610 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 227, "y" : 604 } }, "inputs" : [ { "id" : 86644 } ], "outputs" : [ { "id" : 86637 } ] }, { "id" : 86779, "reactomeId" : 10315616, "displayName" : "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3510, "y" : 1248 }, "minX" : 3435, "maxX" : 3583, "minY" : 1118, "maxY" : 1254, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3583, "y" : 1247 }, "to" : { "x" : 3510, "y" : 1248 } }, { "from" : { "x" : 3510, "y" : 1248 }, "to" : { "x" : 3435, "y" : 1118 } } ], "endShape" : { "a" : { "x" : 3442, "y" : 1122 }, "b" : { "x" : 3435, "y" : 1118 }, "c" : { "x" : 3435, "y" : 1126 }, "type" : "ARROW", "centre" : { "x" : 3435, "y" : 1126 } }, "reactionShape" : { "a" : { "x" : 3504, "y" : 1242 }, "b" : { "x" : 3516, "y" : 1254 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3510, "y" : 1248 } }, "inputs" : [ { "id" : 86752, "points" : [ { "x" : 4294, "y" : 1239 } ] }, { "id" : 86778, "points" : [ { "x" : 3605, "y" : 1117 } ] }, { "id" : 86780, "points" : [ { "x" : 3632, "y" : 1280 } ] } ], "outputs" : [ { "id" : 86781 } ] }, { "id" : 86650, "reactomeId" : 10313259, "displayName" : "IL12B translocates from the cytosol to the extracellular region", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1629, "y" : 621 }, "minX" : 1623, "maxX" : 1638, "minY" : 534, "maxY" : 840, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1629, "y" : 534 }, "to" : { "x" : 1629, "y" : 621 } }, { "from" : { "x" : 1629, "y" : 621 }, "to" : { "x" : 1638, "y" : 840 } } ], "endShape" : { "a" : { "x" : 1634, "y" : 833 }, "b" : { "x" : 1638, "y" : 840 }, "c" : { "x" : 1642, "y" : 833 }, "type" : "ARROW", "centre" : { "x" : 1642, "y" : 833 } }, "reactionShape" : { "a" : { "x" : 1623, "y" : 615 }, "b" : { "x" : 1635, "y" : 627 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1629, "y" : 621 } }, "inputs" : [ { "id" : 86651 } ], "outputs" : [ { "id" : 86621 } ] }, { "id" : 86652, "reactomeId" : 10313415, "displayName" : "IL12B dimerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 878, "y" : 245 }, "minX" : 872, "maxX" : 884, "minY" : 107, "maxY" : 326, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 881, "y" : 107 }, "to" : { "x" : 878, "y" : 245 } }, { "from" : { "x" : 878, "y" : 245 }, "to" : { "x" : 878, "y" : 326 } } ], "endShape" : { "a" : { "x" : 874, "y" : 319 }, "b" : { "x" : 878, "y" : 326 }, "c" : { "x" : 882, "y" : 319 }, "type" : "ARROW", "centre" : { "x" : 882, "y" : 319 } }, "reactionShape" : { "a" : { "x" : 872, "y" : 239 }, "b" : { "x" : 884, "y" : 251 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 878, "y" : 245 } }, "inputs" : [ { "id" : 86642, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86653 } ], "catalysts" : [ { "id" : 86645, "points" : [ { "x" : 594, "y" : 204 } ] } ] }, { "id" : 86654, "reactomeId" : 10313353, "displayName" : "EBI3:CANX binds IL12A", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3322, "y" : 178 }, "minX" : 3316, "maxX" : 3328, "minY" : 161, "maxY" : 210, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3321, "y" : 161 }, "to" : { "x" : 3322, "y" : 178 } }, { "from" : { "x" : 3322, "y" : 178 }, "to" : { "x" : 3321, "y" : 210 } } ], "endShape" : { "a" : { "x" : 3317, "y" : 203 }, "b" : { "x" : 3321, "y" : 210 }, "c" : { "x" : 3325, "y" : 203 }, "type" : "ARROW", "centre" : { "x" : 3325, "y" : 203 } }, "reactionShape" : { "a" : { "x" : 3316, "y" : 172 }, "b" : { "x" : 3328, "y" : 184 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3322, "y" : 178 } }, "inputs" : [ { "id" : 86655, "points" : [ { "x" : 1479, "y" : 85 } ] }, { "id" : 86656, "points" : [ { "x" : 3489, "y" : 109 } ] } ], "outputs" : [ { "id" : 86657 } ] }, { "id" : 86782, "reactomeId" : 10315614, "displayName" : "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3352, "y" : 1139 }, "minX" : 3324, "maxX" : 3383, "minY" : 1133, "maxY" : 1145, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3383, "y" : 1138 }, "to" : { "x" : 3352, "y" : 1139 } }, { "from" : { "x" : 3352, "y" : 1139 }, "to" : { "x" : 3324, "y" : 1140 } } ], "reactionShape" : { "a" : { "x" : 3346, "y" : 1133 }, "b" : { "x" : 3358, "y" : 1145 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3352, "y" : 1139 } }, "inputs" : [ { "id" : 86781, "points" : [ { "x" : 3401, "y" : 1118 } ] }, { "id" : 86783, "points" : [ { "x" : 3400, "y" : 1168 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 86784, "points" : [ { "x" : 3304, "y" : 1169 } ], "stoichiometry" : 2 }, { "id" : 86785, "points" : [ { "x" : 3300, "y" : 1122 } ] } ] } ], "compartments" : [ { "id" : 86801, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 3455, "y" : 1545 }, "minX" : 25, "maxX" : 6886, "minY" : 1088, "maxY" : 2003, "prop" : { "x" : 25, "y" : 1088, "width" : 6861, "height" : 915 }, "textPosition" : { "x" : 61, "y" : 1872 }, "insets" : { "x" : 35, "y" : 1098, "width" : 6841, "height" : 895 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86704, 86681, 86752, 86694, 86690, 86693, 86806, 86703, 86759, 86714, 86683, 86722, 86705, 86789, 86682, 86739, 86706, 86707, 86716, 86717, 86771, 86772, 86786, 86787, 86790, 86780, 86791, 86730, 86788, 86629, 86633, 86640, 86619, 86669, 86632, 86639, 86618, 86670, 86638, 86725, 86680, 86688, 86678, 86679, 86710, 86711, 86726, 86727, 86626, 86687, 86689, 86729, 86692, 86738, 86735, 86712, 86628, 86691, 86700, 86720, 86723, 86721, 86736, 86699, 86701, 86740, 86697, 86743, 86745, 86747, 86751, 86753, 86755, 86756, 86757, 86761, 86762, 86763, 86766, 86768, 86769, 86770, 86774, 86776, 86781, 86783, 86784, 86785, 86748, 86749, 86777, 86778, 86793, 86794, 86799, 86800, 86765, 86696, 86731, 86668, 86677, 86686, 86695, 86698, 86709, 86719, 86724, 86728, 86734, 86737, 86741, 86746, 86750, 86754, 86758, 86760, 86764, 86767, 86775, 86779, 86782, 86792, 86798, 86713, 86826, 86702, 86684 ] }, { "id" : 86805, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 3106, "y" : 330 }, "minX" : 0, "maxX" : 6213, "minY" : 0, "maxY" : 660, "prop" : { "x" : 0, "y" : 0, "width" : 6213, "height" : 660 }, "textPosition" : { "x" : 33, "y" : 577 }, "insets" : { "x" : 10, "y" : 10, "width" : 6193, "height" : 640 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86810, 86651, 86622, 86662, 86673, 86671, 86672, 86674, 86650, 86814, 86675, 86649, 86634 ] }, { "id" : 86806, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 3890, "y" : 1694 }, "minX" : 1027, "maxX" : 6753, "minY" : 1600, "maxY" : 1789, "prop" : { "x" : 1027, "y" : 1600, "width" : 5726, "height" : 189 }, "textPosition" : { "x" : 1178, "y" : 1694 }, "insets" : { "x" : 1037, "y" : 1610, "width" : 5706, "height" : 169 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86685, 86708, 86715, 86718, 86827 ] }, { "id" : 86810, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1950, "y" : 227 }, "minX" : 76, "maxX" : 3825, "minY" : 46, "maxY" : 409, "prop" : { "x" : 76, "y" : 46, "width" : 3749, "height" : 363 }, "textPosition" : { "x" : 266, "y" : 352 }, "insets" : { "x" : 86, "y" : 56, "width" : 3729, "height" : 343 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86641, 86652, 86653, 86642, 86664, 86655, 86663, 86644, 86643, 86654, 86666, 86665, 86656, 86658, 86657, 86660, 86645, 86667, 86732, 86733, 86659, 86623, 86635, 86813 ] }, { "id" : 86826, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 4539, "y" : 1892 }, "minX" : 4271, "maxX" : 4808, "minY" : 1835, "maxY" : 1950, "prop" : { "x" : 4271, "y" : 1835, "width" : 537, "height" : 115 }, "textPosition" : { "x" : 4325, "y" : 1901 }, "insets" : { "x" : 4281, "y" : 1845, "width" : 517, "height" : 95 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 86813, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1327, "y" : 341 }, "minX" : 1206, "maxX" : 1449, "minY" : 301, "maxY" : 382, "prop" : { "x" : 1206, "y" : 301, "width" : 243, "height" : 81 }, "textPosition" : { "x" : 1223, "y" : 336 }, "insets" : { "x" : 1216, "y" : 311, "width" : 223, "height" : 61 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 86814, "reactomeId" : 173031, "displayName" : "late endosome lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1364, "y" : 534 }, "minX" : 1182, "maxX" : 1546, "minY" : 463, "maxY" : 605, "prop" : { "x" : 1182, "y" : 463, "width" : 364, "height" : 142 }, "textPosition" : { "x" : 1195, "y" : 558 }, "insets" : { "x" : 1192, "y" : 473, "width" : 344, "height" : 122 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86647, 86648, 86646 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 86827, "reactomeId" : 10330417, "displayName" : "Interleukin-23 signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 708, "y" : 877 }, "minX" : 79, "maxX" : 1338, "minY" : 71, "maxY" : 1684, "prop" : { "x" : 79, "y" : 71, "width" : 454, "height" : 1613 }, "points" : [ { "x" : 79, "y" : 71 }, { "x" : 1338, "y" : 71 }, { "x" : 1338, "y" : 1684 }, { "x" : 79, "y" : 1684 } ], "colour" : "#4684ee" }, { "id" : 86829, "reactomeId" : 10330423, "displayName" : "Interleukin-27 signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 5160, "y" : 888 }, "minX" : 3456, "maxX" : 6865, "minY" : 72, "maxY" : 1704, "prop" : { "x" : 5590, "y" : 72, "width" : 1275, "height" : 1604 }, "points" : [ { "x" : 3456, "y" : 72 }, { "x" : 6865, "y" : 72 }, { "x" : 6865, "y" : 1704 }, { "x" : 3456, "y" : 1704 } ], "colour" : "#008000" }, { "id" : 86828, "reactomeId" : 10330421, "displayName" : "Interleukin-12 signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1541, "y" : 879 }, "minX" : 533, "maxX" : 2550, "minY" : 64, "maxY" : 1695, "prop" : { "x" : 533, "y" : 64, "width" : 2017, "height" : 1631 }, "points" : [ { "x" : 533, "y" : 64 }, { "x" : 2550, "y" : 64 }, { "x" : 2550, "y" : 1695 }, { "x" : 533, "y" : 1695 } ], "colour" : "#dc3912" }, { "id" : 86830, "reactomeId" : 10330427, "displayName" : "Interleukin-35 Signalling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 3502, "y" : 870 }, "minX" : 1414, "maxX" : 5590, "minY" : 64, "maxY" : 1676, "prop" : { "x" : 2550, "y" : 72, "width" : 906, "height" : 1604 }, "points" : [ { "x" : 1414, "y" : 64 }, { "x" : 5590, "y" : 64 }, { "x" : 5590, "y" : 1676 }, { "x" : 1414, "y" : 1676 } ], "colour" : "#666666" } ], "minX" : 0, "maxX" : 6886, "minY" : 0, "maxY" : 2003, "disease" : false }