{
  "dbId" : 10330409,
  "stId" : "R-CFA-5627123",
  "speciesName" : "Canis familiaris",
  "nodes" : [ {
    "dbId" : 10256477,
    "stId" : "R-CFA-210019",
    "displayName" : "FLNA [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3Q4P5",
    "standardIdentifier" : "uniprot:A0A8I3Q4P5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FLNA" ],
    "parents" : [ 10292657 ],
    "children" : [ ]
  }, {
    "dbId" : 10253022,
    "stId" : "R-CFA-211604",
    "displayName" : "PAK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39723 ],
    "identifier" : "A0A8I3QD39",
    "standardIdentifier" : "uniprot:A0A8I3QD39",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10290605, 10253024 ],
    "children" : [ ]
  }, {
    "dbId" : 10253791,
    "stId" : "R-CFA-399824",
    "displayName" : "phospho-p-S141,T402-PAK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39734 ],
    "identifier" : "A0A8I3QD39",
    "standardIdentifier" : "uniprot:A0A8I3QD39",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10257641, 10253797 ],
    "children" : [ ]
  }, {
    "dbId" : 10253016,
    "stId" : "R-CFA-162629",
    "displayName" : "PAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39719 ],
    "identifier" : "A0A8I3NMF7",
    "standardIdentifier" : "uniprot:A0A8I3NMF7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PAK1" ],
    "parents" : [ 10275428, 10253018 ],
    "children" : [ ]
  }, {
    "dbId" : 10253018,
    "stId" : "R-CFA-445002",
    "displayName" : "PAK1 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39708 ],
    "parents" : [ 10292653 ],
    "children" : [ 10253016 ]
  }, {
    "dbId" : 10253787,
    "stId" : "R-CFA-399819",
    "displayName" : "phospho-PAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39697 ],
    "identifier" : "A0A8I3NMF7",
    "standardIdentifier" : "uniprot:A0A8I3NMF7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PAK1" ],
    "parents" : [ 10292659, 10257641, 10253797 ],
    "children" : [ ]
  }, {
    "dbId" : 10253012,
    "stId" : "R-CFA-389778",
    "displayName" : "CDC42:GTP, RAC1:GTP [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 39691 ],
    "parents" : [ 10290605, 10290607, 10275428 ],
    "children" : [ 10234753, 10240940 ]
  }, {
    "dbId" : 10234116,
    "stId" : "R-CFA-74294",
    "displayName" : "CALM1:4xCa2+ [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39700 ],
    "parents" : [ 10257639 ],
    "children" : [ 10228807, 74016 ]
  }, {
    "dbId" : 10228807,
    "stId" : "R-CFA-9016707",
    "displayName" : "CALM1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PNY6",
    "standardIdentifier" : "uniprot:A0A8I3PNY6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10234116 ],
    "children" : [ ]
  }, {
    "dbId" : 10234753,
    "stId" : "R-CFA-442641",
    "displayName" : "RAC1:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10253012 ],
    "children" : [ 29438, 10234751 ]
  }, {
    "dbId" : 10292604,
    "stId" : "R-CFA-5668975",
    "displayName" : "phospho-p-S1208,S1759-MYLK(1-1914) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39705 ],
    "identifier" : "A0A8I3PX90",
    "standardIdentifier" : "uniprot:A0A8I3PX90",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 74016,
    "stId" : "R-ALL-74016",
    "displayName" : "Ca2+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10234116 ],
    "children" : [ ]
  }, {
    "dbId" : 10329791,
    "stId" : "R-CFA-2029480",
    "displayName" : "Fcgamma receptor (FCGR) dependent phagocytosis",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 39731 ]
  }, {
    "dbId" : 10234751,
    "stId" : "R-CFA-351141",
    "displayName" : "RAC1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "P62999",
    "standardIdentifier" : "uniprot:P62999",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10234753 ],
    "children" : [ ]
  }, {
    "dbId" : 10292664,
    "stId" : "R-CFA-5669246",
    "displayName" : "phospho-FLNA [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3Q4P5",
    "standardIdentifier" : "uniprot:A0A8I3Q4P5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FLNA" ],
    "parents" : [ 10292666 ],
    "children" : [ ]
  }, {
    "dbId" : 10292666,
    "stId" : "R-CFA-5669251",
    "displayName" : "p-S2152-FLNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39717 ],
    "parents" : [ ],
    "children" : [ 10292664 ]
  }, {
    "dbId" : 10292657,
    "stId" : "R-CFA-5669252",
    "displayName" : "FLNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39712 ],
    "parents" : [ 10292659 ],
    "children" : [ 10256477 ]
  }, {
    "dbId" : 10290609,
    "stId" : "R-CFA-8981940",
    "displayName" : "CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 39688 ],
    "parents" : [ ],
    "children" : [ 10275428, 10290607, 10290605 ]
  }, {
    "dbId" : 10292659,
    "stId" : "R-CFA-5669239",
    "displayName" : "p-S144,T423-PAK1:FLNA [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39713 ],
    "parents" : [ ],
    "children" : [ 10292657, 10253787 ]
  }, {
    "dbId" : 10275442,
    "stId" : "R-CFA-5669168",
    "displayName" : "NF2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39709 ],
    "identifier" : "A0A8I3QBP5",
    "standardIdentifier" : "uniprot:A0A8I3QBP5",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10292653 ],
    "children" : [ ]
  }, {
    "dbId" : 10240940,
    "stId" : "R-CFA-182921",
    "displayName" : "CDC42:GTP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10253012 ],
    "children" : [ 29438, 10240938 ]
  }, {
    "dbId" : 10292653,
    "stId" : "R-CFA-5669157",
    "displayName" : "PAK1:NF2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39710 ],
    "parents" : [ ],
    "children" : [ 10275442, 10253018 ]
  }, {
    "dbId" : 10290605,
    "stId" : "R-CFA-8981927",
    "displayName" : "CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39724 ],
    "parents" : [ 10290609 ],
    "children" : [ 10253012, 10253022 ]
  }, {
    "dbId" : 10290607,
    "stId" : "R-CFA-8981928",
    "displayName" : "CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39727 ],
    "parents" : [ 10290609 ],
    "children" : [ 10253028, 10253012 ]
  }, {
    "dbId" : 10253928,
    "stId" : "R-CFA-397785",
    "displayName" : "LIMK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39693 ],
    "identifier" : "A0A8I3RQZ5",
    "standardIdentifier" : "uniprot:A0A8I3RQZ5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LIMK1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10257641,
    "stId" : "R-CFA-5668976",
    "displayName" : "p-S,T-PAK1,2 [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 39702 ],
    "parents" : [ ],
    "children" : [ 10253791, 10253787 ]
  }, {
    "dbId" : 10240938,
    "stId" : "R-CFA-449545",
    "displayName" : "CDC42 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "P60952",
    "standardIdentifier" : "uniprot:P60952",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10240940 ],
    "children" : [ ]
  }, {
    "dbId" : 10253931,
    "stId" : "R-CFA-399816",
    "displayName" : "phospho-LIMK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39695 ],
    "identifier" : "A0A8I3RQZ5",
    "standardIdentifier" : "uniprot:A0A8I3RQZ5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LIMK1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10253028,
    "stId" : "R-CFA-428457",
    "displayName" : "PAK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39728 ],
    "identifier" : "A0A8I3PNN9",
    "standardIdentifier" : "uniprot:A0A8I3PNN9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10290607, 10253030 ],
    "children" : [ ]
  }, {
    "dbId" : 10275428,
    "stId" : "R-CFA-2029159",
    "displayName" : "RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39720 ],
    "parents" : [ 10290609 ],
    "children" : [ 10253012, 10253016 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 39715, 39687, 39704, 39694 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10257637,
    "stId" : "R-CFA-445807",
    "displayName" : "MYLK(1-1914) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 39699 ],
    "identifier" : "A0A8I3PX90",
    "standardIdentifier" : "uniprot:A0A8I3PX90",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10257639 ],
    "children" : [ ]
  }, {
    "dbId" : 10253797,
    "stId" : "R-CFA-399836",
    "displayName" : "p-S,T-PAK1,2,3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 39690 ],
    "parents" : [ ],
    "children" : [ 10253795, 10253787, 10253791 ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 39696, 39716, 39689, 39706 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10253030,
    "stId" : "R-CFA-5669154",
    "displayName" : "PAK3 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39726 ],
    "parents" : [ ],
    "children" : [ 10253028 ]
  }, {
    "dbId" : 10257639,
    "stId" : "R-CFA-445764",
    "displayName" : "MYLK:Ca2+:CALM1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39701 ],
    "parents" : [ ],
    "children" : [ 10257637, 10234116 ]
  }, {
    "dbId" : 10253024,
    "stId" : "R-CFA-2685645",
    "displayName" : "PAK2 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 39722 ],
    "parents" : [ ],
    "children" : [ 10253022 ]
  }, {
    "dbId" : 10330275,
    "stId" : "R-CFA-5627117",
    "displayName" : "RHO GTPases Activate ROCKs",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 39730 ]
  }, {
    "dbId" : 29438,
    "stId" : "R-ALL-29438",
    "displayName" : "GTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "37565",
    "standardIdentifier" : "chebi:37565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10240940, 10234753 ],
    "children" : [ ]
  }, {
    "dbId" : 10253795,
    "stId" : "R-CFA-5357471",
    "displayName" : "phospho-p-S154,T436-PAK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PNN9",
    "standardIdentifier" : "uniprot:A0A8I3PNN9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10253797 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10292669,
    "stId" : "R-CFA-5669250",
    "displayName" : "PAK1 phosphorylates FLNA",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10292661 ],
    "inputs" : [ 10292659, 113592 ],
    "outputs" : [ 29370, 10253787, 10292666 ],
    "catalysts" : [ 10292659 ],
    "efs" : [ ],
    "diagramIds" : [ 39714 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10315327,
    "stId" : "R-CFA-8981926",
    "displayName" : "RAC1 and CDC42 activate PAK3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10290612 ],
    "inputs" : [ 10253030, 10253012 ],
    "outputs" : [ 10253028, 10290607 ],
    "efs" : [ ],
    "diagramIds" : [ 39725 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292607,
    "stId" : "R-CFA-5668984",
    "displayName" : "PAK1 or PAK2 phosphorylates MYLK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10290612 ],
    "inputs" : [ 113592, 10257637 ],
    "outputs" : [ 29370, 10292604 ],
    "catalysts" : [ 10257641 ],
    "efs" : [ ],
    "diagramIds" : [ 39703 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292655,
    "stId" : "R-CFA-5669158",
    "displayName" : "NF2 binds PAK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10275442, 10253018 ],
    "outputs" : [ 10292653 ],
    "efs" : [ ],
    "diagramIds" : [ 39707 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10275450,
    "stId" : "R-CFA-2029460",
    "displayName" : "PAK1 phosphorylates LIMK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10290612 ],
    "inputs" : [ 113592, 10253928 ],
    "outputs" : [ 29370, 10253931 ],
    "catalysts" : [ 10253787 ],
    "efs" : [ ],
    "diagramIds" : [ 39692 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257643,
    "stId" : "R-CFA-445797",
    "displayName" : "MYLK (MLCK) Active Calmodulin Binding",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257637, 10234116 ],
    "outputs" : [ 10257639 ],
    "efs" : [ ],
    "inhibitors" : [ 10257641 ],
    "diagramIds" : [ 39698 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10275444,
    "stId" : "R-CFA-2029456",
    "displayName" : "RAC1 and CDC42 activate PAK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10290612 ],
    "inputs" : [ 10253012, 10253018 ],
    "outputs" : [ 10275428, 10253016 ],
    "efs" : [ ],
    "inhibitors" : [ 10275442 ],
    "diagramIds" : [ 39718 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10292661,
    "stId" : "R-CFA-5669240",
    "displayName" : "FLNA binds PAK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10290612 ],
    "following" : [ 10292669 ],
    "inputs" : [ 10292657, 10253787 ],
    "outputs" : [ 10292659 ],
    "efs" : [ ],
    "diagramIds" : [ 39711 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10290612,
    "stId" : "R-CFA-5627775",
    "displayName" : "Autophosphorylation of PAK1,2,3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10315329, 10275444, 10315327 ],
    "following" : [ 10292661, 10292607, 10275450 ],
    "inputs" : [ 10290609, 113592 ],
    "outputs" : [ 29370, 10253797, 10253012 ],
    "catalysts" : [ 10290609 ],
    "efs" : [ ],
    "diagramIds" : [ 39686 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10315329,
    "stId" : "R-CFA-8981931",
    "displayName" : "RAC1 and CDC42 activate PAK2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10290612 ],
    "inputs" : [ 10253024, 10253012 ],
    "outputs" : [ 10253022, 10290605 ],
    "efs" : [ ],
    "diagramIds" : [ 39721 ],
    "entityFunctionalStatus" : [ ]
  } ]
}