{ "dbId" : 10330295, "stableId" : "R-CFA-9958790", "displayName" : "SLC-mediated transport of inorganic anions", "nodes" : [ { "id" : 44673, "reactomeId" : 109277, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 50, "y" : 308 }, "minX" : 38, "maxX" : 171, "minY" : 277, "maxY" : 324, "prop" : { "x" : 38, "y" : 293, "width" : 25, "height" : 31 }, "textPosition" : { "x" : 41, "y" : 298 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 58, "y" : 298 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 58, "y" : 298 } } }, "connectors" : [ { "edgeId" : 44672, "type" : "INPUT", "segments" : [ { "from" : { "x" : 66, "y" : 309 }, "to" : { "x" : 171, "y" : 319 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44675, "type" : "INPUT", "segments" : [ { "from" : { "x" : 66, "y" : 304 }, "to" : { "x" : 171, "y" : 277 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44674, "reactomeId" : 10255701, "displayName" : "SLC34A3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 170, "y" : 403 }, "minX" : 140, "maxX" : 207, "minY" : 327, "maxY" : 415, "prop" : { "x" : 140, "y" : 392, "width" : 61, "height" : 23 }, "textPosition" : { "x" : 143, "y" : 386 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 201, "y" : 392 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 201, "y" : 392 } } }, "connectors" : [ { "edgeId" : 44672, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 170, "y" : 389 }, "to" : { "x" : 170, "y" : 335 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 170, "y" : 331 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 170, "y" : 331 } } } ] }, { "id" : 44676, "reactomeId" : 74113, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 48, "y" : 236 }, "minX" : 29, "maxX" : 171, "minY" : 220, "maxY" : 277, "prop" : { "x" : 29, "y" : 221, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 31, "y" : 226 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 63, "y" : 226 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 63, "y" : 226 } } }, "connectors" : [ { "edgeId" : 44675, "type" : "INPUT", "segments" : [ { "from" : { "x" : 71, "y" : 242 }, "to" : { "x" : 171, "y" : 277 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 115, "y" : 253 }, "b" : { "x" : 127, "y" : 265 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 121, "y" : 259 } } } } ] }, { "id" : 44677, "reactomeId" : 10255694, "displayName" : "Type III Na+/Pi cotransporters", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 172, "y" : 200 }, "minX" : 121, "maxX" : 224, "minY" : 182, "maxY" : 269, "prop" : { "x" : 121, "y" : 182, "width" : 103, "height" : 37 }, "textPosition" : { "x" : 121, "y" : 183 }, "connectors" : [ { "edgeId" : 44675, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 171, "y" : 225 }, "to" : { "x" : 171, "y" : 261 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 171, "y" : 265 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 171, "y" : 265 } } } ] }, { "id" : 44679, "reactomeId" : 10255960, "displayName" : "SLC17A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 465, "y" : 142 }, "minX" : 409, "maxX" : 505, "minY" : 123, "maxY" : 156, "prop" : { "x" : 432, "y" : 129, "width" : 67, "height" : 27 }, "textPosition" : { "x" : 434, "y" : 132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 499, "y" : 129 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 499, "y" : 129 } } }, "connectors" : [ { "edgeId" : 44678, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 429, "y" : 142 }, "to" : { "x" : 417, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 413, "y" : 143 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 413, "y" : 143 } } } ] }, { "id" : 44597, "reactomeId" : 74113, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 51, "y" : 475 }, "minX" : 32, "maxX" : 171, "minY" : 319, "maxY" : 548, "prop" : { "x" : 32, "y" : 460, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 34, "y" : 465 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 66, "y" : 465 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 66, "y" : 465 } } }, "connectors" : [ { "edgeId" : 44672, "type" : "INPUT", "segments" : [ { "from" : { "x" : 62, "y" : 457 }, "to" : { "x" : 171, "y" : 319 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 110, "y" : 382 }, "b" : { "x" : 122, "y" : 394 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 116, "y" : 388 } } } }, { "edgeId" : 44596, "type" : "INPUT", "segments" : [ { "from" : { "x" : 74, "y" : 486 }, "to" : { "x" : 170, "y" : 548 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44602, "type" : "INPUT", "segments" : [ { "from" : { "x" : 74, "y" : 478 }, "to" : { "x" : 171, "y" : 498 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 116, "y" : 482 }, "b" : { "x" : 128, "y" : 494 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 122, "y" : 488 } } } } ] }, { "id" : 44598, "reactomeId" : 427648, "displayName" : "SO4(2-)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 58, "y" : 591 }, "minX" : 29, "maxX" : 174, "minY" : 498, "maxY" : 653, "prop" : { "x" : 29, "y" : 576, "width" : 58, "height" : 31 }, "textPosition" : { "x" : 30, "y" : 581 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 82, "y" : 581 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 82, "y" : 581 } } }, "connectors" : [ { "edgeId" : 44652, "type" : "INPUT", "segments" : [ { "from" : { "x" : 90, "y" : 606 }, "to" : { "x" : 174, "y" : 653 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44596, "type" : "INPUT", "segments" : [ { "from" : { "x" : 90, "y" : 579 }, "to" : { "x" : 170, "y" : 548 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44602, "type" : "INPUT", "segments" : [ { "from" : { "x" : 76, "y" : 573 }, "to" : { "x" : 171, "y" : 498 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44599, "reactomeId" : 83910, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 282, "y" : 470 }, "minX" : 170, "maxX" : 303, "minY" : 277, "maxY" : 546, "prop" : { "x" : 263, "y" : 455, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 265, "y" : 460 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 297, "y" : 460 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 297, "y" : 460 } } }, "connectors" : [ { "edgeId" : 44672, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 270, "y" : 452 }, "to" : { "x" : 170, "y" : 319 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 214, "y" : 379 }, "b" : { "x" : 226, "y" : 391 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 220, "y" : 385 } } }, "endShape" : { "a" : { "x" : 263, "y" : 449 }, "b" : { "x" : 270, "y" : 452 }, "c" : { "x" : 269, "y" : 444 }, "type" : "ARROW", "centre" : { "x" : 269, "y" : 444 } } }, { "edgeId" : 44675, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 273, "y" : 452 }, "to" : { "x" : 171, "y" : 277 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 216, "y" : 358 }, "b" : { "x" : 228, "y" : 370 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 222, "y" : 364 } } }, "endShape" : { "a" : { "x" : 266, "y" : 448 }, "b" : { "x" : 273, "y" : 452 }, "c" : { "x" : 273, "y" : 444 }, "type" : "ARROW", "centre" : { "x" : 273, "y" : 444 } } }, { "edgeId" : 44596, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 260, "y" : 483 }, "to" : { "x" : 172, "y" : 546 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 257, "y" : 490 }, "b" : { "x" : 260, "y" : 483 }, "c" : { "x" : 252, "y" : 484 }, "type" : "ARROW", "centre" : { "x" : 252, "y" : 484 } } }, { "edgeId" : 44602, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 260, "y" : 475 }, "to" : { "x" : 170, "y" : 500 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 209, "y" : 481 }, "b" : { "x" : 221, "y" : 493 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 215, "y" : 487 } } }, "endShape" : { "a" : { "x" : 254, "y" : 481 }, "b" : { "x" : 260, "y" : 475 }, "c" : { "x" : 252, "y" : 473 }, "type" : "ARROW", "centre" : { "x" : 252, "y" : 473 } } } ] }, { "id" : 44600, "reactomeId" : 174375, "displayName" : "SO4(2-)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 285, "y" : 592 }, "minX" : 170, "maxX" : 315, "minY" : 500, "maxY" : 657, "prop" : { "x" : 256, "y" : 577, "width" : 58, "height" : 31 }, "textPosition" : { "x" : 257, "y" : 582 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 309, "y" : 582 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 309, "y" : 582 } } }, "connectors" : [ { "edgeId" : 44652, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 258, "y" : 611 }, "to" : { "x" : 175, "y" : 657 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 254, "y" : 618 }, "b" : { "x" : 258, "y" : 611 }, "c" : { "x" : 250, "y" : 611 }, "type" : "ARROW", "centre" : { "x" : 250, "y" : 611 } } }, { "edgeId" : 44596, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 253, "y" : 580 }, "to" : { "x" : 172, "y" : 546 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 245, "y" : 581 }, "b" : { "x" : 253, "y" : 580 }, "c" : { "x" : 248, "y" : 574 }, "type" : "ARROW", "centre" : { "x" : 248, "y" : 574 } } }, { "edgeId" : 44602, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 265, "y" : 574 }, "to" : { "x" : 170, "y" : 500 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 257, "y" : 573 }, "b" : { "x" : 265, "y" : 574 }, "c" : { "x" : 262, "y" : 567 }, "type" : "ARROW", "centre" : { "x" : 262, "y" : 567 } } } ] }, { "id" : 44601, "reactomeId" : 10256887, "displayName" : "SLC13A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 172, "y" : 600 }, "minX" : 139, "maxX" : 212, "minY" : 554, "maxY" : 614, "prop" : { "x" : 139, "y" : 587, "width" : 67, "height" : 27 }, "textPosition" : { "x" : 141, "y" : 590 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 206, "y" : 587 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 206, "y" : 587 } } }, "connectors" : [ { "edgeId" : 44596, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 171, "y" : 584 }, "to" : { "x" : 171, "y" : 562 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 171, "y" : 558 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 171, "y" : 558 } } } ] }, { "id" : 44603, "reactomeId" : 10256866, "displayName" : "SLC13A4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 171, "y" : 436 }, "minX" : 139, "maxX" : 210, "minY" : 418, "maxY" : 490, "prop" : { "x" : 139, "y" : 424, "width" : 65, "height" : 25 }, "textPosition" : { "x" : 140, "y" : 426 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 204, "y" : 424 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 204, "y" : 424 } } }, "connectors" : [ { "edgeId" : 44602, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 170, "y" : 452 }, "to" : { "x" : 170, "y" : 482 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 170, "y" : 486 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 170, "y" : 486 } } } ] }, { "id" : 44605, "reactomeId" : 209818, "displayName" : "I-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 574, "y" : 28 }, "minX" : 525, "maxX" : 587, "minY" : 12, "maxY" : 142, "prop" : { "x" : 563, "y" : 13, "width" : 23, "height" : 31 }, "textPosition" : { "x" : 567, "y" : 18 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 581, "y" : 18 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 581, "y" : 18 } } }, "connectors" : [ { "edgeId" : 44610, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 567, "y" : 47 }, "to" : { "x" : 525, "y" : 142 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44606, "reactomeId" : 74113, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 468, "y" : 27 }, "minX" : 348, "maxX" : 525, "minY" : 11, "maxY" : 143, "prop" : { "x" : 449, "y" : 12, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 451, "y" : 17 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 483, "y" : 17 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 483, "y" : 17 } } }, "connectors" : [ { "edgeId" : 44678, "type" : "INPUT", "segments" : [ { "from" : { "x" : 459, "y" : 46 }, "to" : { "x" : 403, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44604, "type" : "INPUT", "segments" : [ { "from" : { "x" : 475, "y" : 46 }, "to" : { "x" : 525, "y" : 142 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44668, "type" : "INPUT", "segments" : [ { "from" : { "x" : 451, "y" : 46 }, "to" : { "x" : 348, "y" : 143 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 393, "y" : 88 }, "b" : { "x" : 405, "y" : 100 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 399, "y" : 94 } } } } ] }, { "id" : 44607, "reactomeId" : 209785, "displayName" : "I-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 584, "y" : 231 }, "minX" : 525, "maxX" : 597, "minY" : 143, "maxY" : 247, "prop" : { "x" : 573, "y" : 216, "width" : 23, "height" : 31 }, "textPosition" : { "x" : 577, "y" : 221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 591, "y" : 221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 591, "y" : 221 } } }, "connectors" : [ { "edgeId" : 44610, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 573, "y" : 213 }, "to" : { "x" : 525, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 566, "y" : 210 }, "b" : { "x" : 573, "y" : 213 }, "c" : { "x" : 572, "y" : 205 }, "type" : "ARROW", "centre" : { "x" : 572, "y" : 205 } } } ] }, { "id" : 44608, "reactomeId" : 83910, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 476, "y" : 230 }, "minX" : 348, "maxX" : 525, "minY" : 143, "maxY" : 246, "prop" : { "x" : 457, "y" : 215, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 459, "y" : 220 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 491, "y" : 220 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 491, "y" : 220 } } }, "connectors" : [ { "edgeId" : 44678, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 462, "y" : 212 }, "to" : { "x" : 403, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 454, "y" : 209 }, "b" : { "x" : 462, "y" : 212 }, "c" : { "x" : 461, "y" : 204 }, "type" : "ARROW", "centre" : { "x" : 461, "y" : 204 } } }, { "edgeId" : 44604, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 484, "y" : 212 }, "to" : { "x" : 525, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 484, "y" : 204 }, "b" : { "x" : 484, "y" : 212 }, "c" : { "x" : 491, "y" : 208 }, "type" : "ARROW", "centre" : { "x" : 491, "y" : 208 } } }, { "edgeId" : 44668, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 454, "y" : 216 }, "to" : { "x" : 348, "y" : 144 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 395, "y" : 174 }, "b" : { "x" : 407, "y" : 186 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 401, "y" : 180 } } }, "endShape" : { "a" : { "x" : 446, "y" : 215 }, "b" : { "x" : 454, "y" : 216 }, "c" : { "x" : 451, "y" : 209 }, "type" : "ARROW", "centre" : { "x" : 451, "y" : 209 } } } ] }, { "id" : 44609, "reactomeId" : 10246997, "displayName" : "SLC5A5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 599, "y" : 145 }, "minX" : 533, "maxX" : 635, "minY" : 126, "maxY" : 159, "prop" : { "x" : 570, "y" : 132, "width" : 59, "height" : 27 }, "textPosition" : { "x" : 572, "y" : 135 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 629, "y" : 132 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 629, "y" : 132 } } }, "connectors" : [ { "edgeId" : 44604, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 567, "y" : 143 }, "to" : { "x" : 541, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 537, "y" : 142 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 537, "y" : 142 } } } ] }, { "id" : 44611, "reactomeId" : 10256197, "displayName" : "SLC5A8", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 721, "y" : 142 }, "minX" : 669, "maxX" : 757, "minY" : 124, "maxY" : 155, "prop" : { "x" : 692, "y" : 130, "width" : 59, "height" : 25 }, "textPosition" : { "x" : 694, "y" : 132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 751, "y" : 130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 751, "y" : 130 } } }, "connectors" : [ { "edgeId" : 44610, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 689, "y" : 142 }, "to" : { "x" : 677, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 673, "y" : 143 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 673, "y" : 143 } } } ] }, { "id" : 44613, "reactomeId" : 188972, "displayName" : "Cl-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 943, "y" : 24 }, "minX" : 792, "maxX" : 1054, "minY" : 8, "maxY" : 144, "prop" : { "x" : 927, "y" : 9, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 932, "y" : 14 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 955, "y" : 14 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 955, "y" : 14 } } }, "connectors" : [ { "edgeId" : 44612, "type" : "INPUT", "segments" : [ { "from" : { "x" : 957, "y" : 43 }, "to" : { "x" : 1054, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44656, "type" : "INPUT", "segments" : [ { "from" : { "x" : 953, "y" : 43 }, "to" : { "x" : 1025, "y" : 141 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44660, "type" : "INPUT", "segments" : [ { "from" : { "x" : 924, "y" : 37 }, "to" : { "x" : 792, "y" : 144 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44614, "reactomeId" : 111627, "displayName" : "HCO3-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1143, "y" : 235 }, "minX" : 1025, "maxX" : 1211, "minY" : 141, "maxY" : 251, "prop" : { "x" : 1115, "y" : 220, "width" : 56, "height" : 31 }, "textPosition" : { "x" : 1120, "y" : 225 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1166, "y" : 225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1166, "y" : 225 } } }, "connectors" : [ { "edgeId" : 44612, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1128, "y" : 217 }, "to" : { "x" : 1054, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44618, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1154, "y" : 217 }, "to" : { "x" : 1211, "y" : 143 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1176, "y" : 174 }, "b" : { "x" : 1188, "y" : 186 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1182, "y" : 180 } } } }, { "edgeId" : 44656, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1123, "y" : 217 }, "to" : { "x" : 1025, "y" : 141 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44615, "reactomeId" : 352022, "displayName" : "Cl-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 942, "y" : 228 }, "minX" : 792, "maxX" : 1054, "minY" : 142, "maxY" : 244, "prop" : { "x" : 926, "y" : 213, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 931, "y" : 218 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 954, "y" : 218 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 954, "y" : 218 } } }, "connectors" : [ { "edgeId" : 44612, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 962, "y" : 215 }, "to" : { "x" : 1054, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 965, "y" : 208 }, "b" : { "x" : 962, "y" : 215 }, "c" : { "x" : 970, "y" : 214 }, "type" : "ARROW", "centre" : { "x" : 970, "y" : 214 } } }, { "edgeId" : 44656, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 957, "y" : 210 }, "to" : { "x" : 1026, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 959, "y" : 202 }, "b" : { "x" : 957, "y" : 210 }, "c" : { "x" : 965, "y" : 208 }, "type" : "ARROW", "centre" : { "x" : 965, "y" : 208 } } }, { "edgeId" : 44660, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 923, "y" : 218 }, "to" : { "x" : 792, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 915, "y" : 218 }, "b" : { "x" : 923, "y" : 218 }, "c" : { "x" : 919, "y" : 211 }, "type" : "ARROW", "centre" : { "x" : 919, "y" : 211 } } } ] }, { "id" : 44616, "reactomeId" : 425425, "displayName" : "HCO3-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1133, "y" : 18 }, "minX" : 1026, "maxX" : 1210, "minY" : 2, "maxY" : 143, "prop" : { "x" : 1105, "y" : 3, "width" : 56, "height" : 31 }, "textPosition" : { "x" : 1110, "y" : 8 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1156, "y" : 8 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1156, "y" : 8 } } }, "connectors" : [ { "edgeId" : 44612, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1123, "y" : 37 }, "to" : { "x" : 1054, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1123, "y" : 45 }, "b" : { "x" : 1123, "y" : 37 }, "c" : { "x" : 1116, "y" : 41 }, "type" : "ARROW", "centre" : { "x" : 1116, "y" : 41 } } }, { "edgeId" : 44618, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1142, "y" : 37 }, "to" : { "x" : 1210, "y" : 143 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1170, "y" : 84 }, "b" : { "x" : 1182, "y" : 96 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1176, "y" : 90 } } }, "endShape" : { "a" : { "x" : 1149, "y" : 41 }, "b" : { "x" : 1142, "y" : 37 }, "c" : { "x" : 1142, "y" : 45 }, "type" : "ARROW", "centre" : { "x" : 1142, "y" : 45 } } }, { "edgeId" : 44656, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1119, "y" : 37 }, "to" : { "x" : 1026, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1117, "y" : 45 }, "b" : { "x" : 1119, "y" : 37 }, "c" : { "x" : 1111, "y" : 40 }, "type" : "ARROW", "centre" : { "x" : 1111, "y" : 40 } } } ] }, { "id" : 44617, "reactomeId" : 10255301, "displayName" : "SLC4A1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1133, "y" : 144 }, "minX" : 1062, "maxX" : 1175, "minY" : 132, "maxY" : 157, "prop" : { "x" : 1092, "y" : 132, "width" : 83, "height" : 25 }, "textPosition" : { "x" : 1094, "y" : 134 }, "connectors" : [ { "edgeId" : 44612, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1086, "y" : 142 }, "to" : { "x" : 1070, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1066, "y" : 142 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1066, "y" : 142 } } } ] }, { "id" : 44619, "reactomeId" : 83910, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1298, "y" : 226 }, "minX" : 1211, "maxX" : 1382, "minY" : 142, "maxY" : 242, "prop" : { "x" : 1279, "y" : 211, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 1281, "y" : 216 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1313, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1313, "y" : 216 } } }, "connectors" : [ { "edgeId" : 44618, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1281, "y" : 208 }, "to" : { "x" : 1211, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44622, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1313, "y" : 208 }, "to" : { "x" : 1382, "y" : 142 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44620, "reactomeId" : 74113, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1288, "y" : 23 }, "minX" : 1210, "maxX" : 1382, "minY" : 7, "maxY" : 145, "prop" : { "x" : 1269, "y" : 8, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 1271, "y" : 13 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1303, "y" : 13 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1303, "y" : 13 } } }, "connectors" : [ { "edgeId" : 44618, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1277, "y" : 42 }, "to" : { "x" : 1210, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1277, "y" : 50 }, "b" : { "x" : 1277, "y" : 42 }, "c" : { "x" : 1270, "y" : 46 }, "type" : "ARROW", "centre" : { "x" : 1270, "y" : 46 } } }, { "edgeId" : 44622, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1299, "y" : 42 }, "to" : { "x" : 1382, "y" : 145 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1306, "y" : 45 }, "b" : { "x" : 1299, "y" : 42 }, "c" : { "x" : 1300, "y" : 50 }, "type" : "ARROW", "centre" : { "x" : 1300, "y" : 50 } } } ] }, { "id" : 44621, "reactomeId" : 10255318, "displayName" : "SLC4A5,7,9", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1304, "y" : 141 }, "minX" : 1220, "maxX" : 1346, "minY" : 129, "maxY" : 154, "prop" : { "x" : 1263, "y" : 129, "width" : 83, "height" : 25 }, "textPosition" : { "x" : 1265, "y" : 131 }, "connectors" : [ { "edgeId" : 44618, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1257, "y" : 141 }, "to" : { "x" : 1228, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1224, "y" : 142 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1224, "y" : 142 } } } ] }, { "id" : 44623, "reactomeId" : 111627, "displayName" : "HCO3-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1444, "y" : 227 }, "minX" : 1382, "maxX" : 1545, "minY" : 142, "maxY" : 243, "prop" : { "x" : 1416, "y" : 212, "width" : 56, "height" : 31 }, "textPosition" : { "x" : 1421, "y" : 217 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1467, "y" : 217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1467, "y" : 217 } } }, "connectors" : [ { "edgeId" : 44622, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1432, "y" : 209 }, "to" : { "x" : 1382, "y" : 142 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1401, "y" : 169 }, "b" : { "x" : 1413, "y" : 181 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1407, "y" : 175 } } } }, { "edgeId" : 44627, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1462, "y" : 209 }, "to" : { "x" : 1545, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1465, "y" : 202 }, "b" : { "x" : 1462, "y" : 209 }, "c" : { "x" : 1470, "y" : 208 }, "type" : "ARROW", "centre" : { "x" : 1470, "y" : 208 } } } ] }, { "id" : 44624, "reactomeId" : 425425, "displayName" : "HCO3-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1423, "y" : 23 }, "minX" : 1382, "maxX" : 1545, "minY" : 7, "maxY" : 145, "prop" : { "x" : 1395, "y" : 8, "width" : 56, "height" : 31 }, "textPosition" : { "x" : 1400, "y" : 13 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1446, "y" : 13 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1446, "y" : 13 } } }, "connectors" : [ { "edgeId" : 44622, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1417, "y" : 42 }, "to" : { "x" : 1382, "y" : 145 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1393, "y" : 87 }, "b" : { "x" : 1405, "y" : 99 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1399, "y" : 93 } } }, "endShape" : { "a" : { "x" : 1419, "y" : 50 }, "b" : { "x" : 1417, "y" : 42 }, "c" : { "x" : 1411, "y" : 47 }, "type" : "ARROW", "centre" : { "x" : 1411, "y" : 47 } } }, { "edgeId" : 44627, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1438, "y" : 42 }, "to" : { "x" : 1545, "y" : 142 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44625, "reactomeId" : 10311223, "displayName" : "SLC4A4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1473, "y" : 141 }, "minX" : 1389, "maxX" : 1511, "minY" : 123, "maxY" : 154, "prop" : { "x" : 1442, "y" : 129, "width" : 63, "height" : 25 }, "textPosition" : { "x" : 1446, "y" : 131 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1505, "y" : 129 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1505, "y" : 129 } } }, "connectors" : [ { "edgeId" : 44622, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1439, "y" : 141 }, "to" : { "x" : 1397, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1393, "y" : 143 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1393, "y" : 143 } } } ] }, { "id" : 44626, "reactomeId" : 10311228, "displayName" : "AHCYL2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1376, "y" : 249 }, "minX" : 1348, "maxX" : 1411, "minY" : 152, "maxY" : 261, "prop" : { "x" : 1348, "y" : 238, "width" : 57, "height" : 23 }, "textPosition" : { "x" : 1349, "y" : 239 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1405, "y" : 238 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1405, "y" : 238 } } }, "connectors" : [ { "edgeId" : 44622, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1376, "y" : 235 }, "to" : { "x" : 1381, "y" : 152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1385, "y" : 159 }, "b" : { "x" : 1381, "y" : 152 }, "c" : { "x" : 1377, "y" : 159 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1377, "y" : 159 } } } ] }, { "id" : 44628, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1613, "y" : 264 }, "minX" : 1545, "maxX" : 1631, "minY" : 142, "maxY" : 280, "prop" : { "x" : 1597, "y" : 249, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 1600, "y" : 254 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1625, "y" : 254 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1625, "y" : 254 } } }, "connectors" : [ { "edgeId" : 44627, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1604, "y" : 246 }, "to" : { "x" : 1545, "y" : 142 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 44629, "reactomeId" : 352022, "displayName" : "Cl-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1547, "y" : 229 }, "minX" : 1531, "maxX" : 1565, "minY" : 142, "maxY" : 245, "prop" : { "x" : 1531, "y" : 214, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 1536, "y" : 219 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1559, "y" : 219 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1559, "y" : 219 } } }, "connectors" : [ { "edgeId" : 44627, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1546, "y" : 211 }, "to" : { "x" : 1545, "y" : 142 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44630, "reactomeId" : 74113, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1666, "y" : 28 }, "minX" : 1545, "maxX" : 1788, "minY" : 12, "maxY" : 143, "prop" : { "x" : 1647, "y" : 13, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 1649, "y" : 18 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1681, "y" : 18 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1681, "y" : 18 } } }, "connectors" : [ { "edgeId" : 44627, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1649, "y" : 47 }, "to" : { "x" : 1545, "y" : 142 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44635, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1682, "y" : 47 }, "to" : { "x" : 1788, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44631, "reactomeId" : 351626, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1597, "y" : 18 }, "minX" : 1545, "maxX" : 1615, "minY" : 2, "maxY" : 143, "prop" : { "x" : 1581, "y" : 3, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 1584, "y" : 8 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1609, "y" : 8 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1609, "y" : 8 } } }, "connectors" : [ { "edgeId" : 44627, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1590, "y" : 37 }, "to" : { "x" : 1545, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1591, "y" : 45 }, "b" : { "x" : 1590, "y" : 37 }, "c" : { "x" : 1584, "y" : 42 }, "type" : "ARROW", "centre" : { "x" : 1584, "y" : 42 } } } ], "trivial" : true }, { "id" : 44632, "reactomeId" : 188972, "displayName" : "Cl-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1539, "y" : 16 }, "minX" : 1523, "maxX" : 1557, "minY" : 0, "maxY" : 143, "prop" : { "x" : 1523, "y" : 1, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 1528, "y" : 6 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1551, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1551, "y" : 6 } } }, "connectors" : [ { "edgeId" : 44627, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1539, "y" : 35 }, "to" : { "x" : 1545, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1543, "y" : 42 }, "b" : { "x" : 1539, "y" : 35 }, "c" : { "x" : 1535, "y" : 42 }, "type" : "ARROW", "centre" : { "x" : 1535, "y" : 42 } } } ] }, { "id" : 44633, "reactomeId" : 83910, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1671, "y" : 231 }, "minX" : 1545, "maxX" : 1793, "minY" : 143, "maxY" : 247, "prop" : { "x" : 1652, "y" : 216, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 1654, "y" : 221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1686, "y" : 221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1686, "y" : 221 } } }, "connectors" : [ { "edgeId" : 44627, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1649, "y" : 217 }, "to" : { "x" : 1545, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1641, "y" : 216 }, "b" : { "x" : 1649, "y" : 217 }, "c" : { "x" : 1646, "y" : 210 }, "type" : "ARROW", "centre" : { "x" : 1646, "y" : 210 } } }, { "edgeId" : 44635, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1694, "y" : 217 }, "to" : { "x" : 1793, "y" : 147 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1697, "y" : 210 }, "b" : { "x" : 1694, "y" : 217 }, "c" : { "x" : 1702, "y" : 216 }, "type" : "ARROW", "centre" : { "x" : 1702, "y" : 216 } } } ] }, { "id" : 44634, "reactomeId" : 10255331, "displayName" : "Na+-driven Cl-/HCO3- exchanger proteins", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1673, "y" : 142 }, "minX" : 1553, "maxX" : 1731, "minY" : 117, "maxY" : 168, "prop" : { "x" : 1615, "y" : 117, "width" : 116, "height" : 51 }, "textPosition" : { "x" : 1625, "y" : 111 }, "connectors" : [ { "edgeId" : 44627, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1609, "y" : 142 }, "to" : { "x" : 1561, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1557, "y" : 142 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1557, "y" : 142 } } } ] }, { "id" : 44636, "reactomeId" : 188972, "displayName" : "Cl-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1787, "y" : 20 }, "minX" : 1771, "maxX" : 2047, "minY" : 4, "maxY" : 143, "prop" : { "x" : 1771, "y" : 5, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 1776, "y" : 10 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1799, "y" : 10 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1799, "y" : 10 } } }, "connectors" : [ { "edgeId" : 44642, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1807, "y" : 20 }, "to" : { "x" : 1965, "y" : 20 } }, { "from" : { "x" : 1965, "y" : 20 }, "to" : { "x" : 2047, "y" : 141 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1880, "y" : 14 }, "b" : { "x" : 1892, "y" : 26 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1886, "y" : 20 } } } }, { "edgeId" : 44635, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1787, "y" : 39 }, "to" : { "x" : 1788, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44637, "reactomeId" : 352022, "displayName" : "Cl-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1791, "y" : 230 }, "minX" : 1775, "maxX" : 2048, "minY" : 142, "maxY" : 246, "prop" : { "x" : 1775, "y" : 215, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 1780, "y" : 220 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1803, "y" : 220 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1803, "y" : 220 } } }, "connectors" : [ { "edgeId" : 44642, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1811, "y" : 229 }, "to" : { "x" : 1973, "y" : 229 } }, { "from" : { "x" : 1973, "y" : 229 }, "to" : { "x" : 2048, "y" : 142 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1886, "y" : 223 }, "b" : { "x" : 1898, "y" : 235 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1892, "y" : 229 } } }, "endShape" : { "a" : { "x" : 1818, "y" : 225 }, "b" : { "x" : 1811, "y" : 229 }, "c" : { "x" : 1818, "y" : 233 }, "type" : "ARROW", "centre" : { "x" : 1818, "y" : 233 } } }, { "edgeId" : 44635, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1791, "y" : 212 }, "to" : { "x" : 1793, "y" : 147 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1787, "y" : 205 }, "b" : { "x" : 1791, "y" : 212 }, "c" : { "x" : 1795, "y" : 205 }, "type" : "ARROW", "centre" : { "x" : 1795, "y" : 205 } } } ] }, { "id" : 44638, "reactomeId" : 10255480, "displayName" : "SLC12A3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1870, "y" : 145 }, "minX" : 1798, "maxX" : 1912, "minY" : 112, "maxY" : 158, "prop" : { "x" : 1835, "y" : 133, "width" : 70, "height" : 25 }, "textPosition" : { "x" : 1839, "y" : 135 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1905, "y" : 133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1905, "y" : 133 } } }, "connectors" : [ { "edgeId" : 44635, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1832, "y" : 144 }, "to" : { "x" : 1806, "y" : 144 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1802, "y" : 144 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1802, "y" : 144 } } }, { "edgeId" : 44639, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1885, "y" : 130 }, "to" : { "x" : 1912, "y" : 112 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44640, "reactomeId" : 9725703, "displayName" : "SLC12A3 inhibitors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1864, "y" : 55 }, "minX" : 1831, "maxX" : 1912, "minY" : 40, "maxY" : 112, "prop" : { "x" : 1831, "y" : 40, "width" : 66, "height" : 31 }, "textPosition" : { "x" : 1831, "y" : 38 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 44639, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1877, "y" : 77 }, "to" : { "x" : 1912, "y" : 112 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44641, "reactomeId" : 10321740, "displayName" : "SLC12A3:SLC12A3 inhibitors", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1980, "y" : 146 }, "minX" : 1940, "maxX" : 2026, "minY" : 116, "maxY" : 171, "prop" : { "x" : 1940, "y" : 122, "width" : 80, "height" : 49 }, "textPosition" : { "x" : 1947, "y" : 122 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2020, "y" : 122 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2020, "y" : 122 } } }, "connectors" : [ { "edgeId" : 44639, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44643, "reactomeId" : 74126, "displayName" : "K+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2143, "y" : 17 }, "minX" : 2047, "maxX" : 2221, "minY" : 1, "maxY" : 141, "prop" : { "x" : 2128, "y" : 2, "width" : 30, "height" : 31 }, "textPosition" : { "x" : 2130, "y" : 7 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2153, "y" : 7 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2153, "y" : 7 } } }, "connectors" : [ { "edgeId" : 44642, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2131, "y" : 36 }, "to" : { "x" : 2047, "y" : 141 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44648, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2156, "y" : 36 }, "to" : { "x" : 2221, "y" : 108 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2164, "y" : 38 }, "b" : { "x" : 2156, "y" : 36 }, "c" : { "x" : 2158, "y" : 44 }, "type" : "ARROW", "centre" : { "x" : 2158, "y" : 44 } } } ] }, { "id" : 44644, "reactomeId" : 74113, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2057, "y" : 24 }, "minX" : 2038, "maxX" : 2078, "minY" : 8, "maxY" : 141, "prop" : { "x" : 2038, "y" : 9, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 2040, "y" : 14 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2072, "y" : 14 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2072, "y" : 14 } } }, "connectors" : [ { "edgeId" : 44642, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2055, "y" : 43 }, "to" : { "x" : 2047, "y" : 141 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44645, "reactomeId" : 29804, "displayName" : "K+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2154, "y" : 236 }, "minX" : 2048, "maxX" : 2221, "minY" : 142, "maxY" : 252, "prop" : { "x" : 2139, "y" : 221, "width" : 30, "height" : 31 }, "textPosition" : { "x" : 2141, "y" : 226 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2164, "y" : 226 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2164, "y" : 226 } } }, "connectors" : [ { "edgeId" : 44642, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2136, "y" : 222 }, "to" : { "x" : 2048, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2128, "y" : 220 }, "b" : { "x" : 2136, "y" : 222 }, "c" : { "x" : 2134, "y" : 214 }, "type" : "ARROW", "centre" : { "x" : 2134, "y" : 214 } } }, { "edgeId" : 44648, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2172, "y" : 229 }, "to" : { "x" : 2221, "y" : 208 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44646, "reactomeId" : 83910, "displayName" : "Na+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2068, "y" : 231 }, "minX" : 2048, "maxX" : 2089, "minY" : 142, "maxY" : 247, "prop" : { "x" : 2049, "y" : 216, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 2051, "y" : 221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2083, "y" : 221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2083, "y" : 221 } } }, "connectors" : [ { "edgeId" : 44642, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2064, "y" : 213 }, "to" : { "x" : 2048, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2059, "y" : 207 }, "b" : { "x" : 2064, "y" : 213 }, "c" : { "x" : 2066, "y" : 205 }, "type" : "ARROW", "centre" : { "x" : 2066, "y" : 205 } } } ] }, { "id" : 44647, "reactomeId" : 10255473, "displayName" : "SLC12A1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2139, "y" : 145 }, "minX" : 2056, "maxX" : 2177, "minY" : 133, "maxY" : 158, "prop" : { "x" : 2102, "y" : 133, "width" : 75, "height" : 25 }, "textPosition" : { "x" : 2102, "y" : 135 }, "connectors" : [ { "edgeId" : 44642, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2096, "y" : 144 }, "to" : { "x" : 2064, "y" : 144 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2060, "y" : 144 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2060, "y" : 144 } } } ] }, { "id" : 44649, "reactomeId" : 352022, "displayName" : "Cl-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2296, "y" : 234 }, "minX" : 2221, "maxX" : 2314, "minY" : 208, "maxY" : 250, "prop" : { "x" : 2280, "y" : 219, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 2285, "y" : 224 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2308, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2308, "y" : 224 } } }, "connectors" : [ { "edgeId" : 44648, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2277, "y" : 228 }, "to" : { "x" : 2221, "y" : 208 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44658, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44650, "reactomeId" : 188972, "displayName" : "Cl-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2297, "y" : 17 }, "minX" : 2221, "maxX" : 2315, "minY" : 1, "maxY" : 108, "prop" : { "x" : 2281, "y" : 2, "width" : 33, "height" : 31 }, "textPosition" : { "x" : 2286, "y" : 7 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2309, "y" : 7 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2309, "y" : 7 } } }, "connectors" : [ { "edgeId" : 44648, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2284, "y" : 36 }, "to" : { "x" : 2221, "y" : 108 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2282, "y" : 44 }, "b" : { "x" : 2284, "y" : 36 }, "c" : { "x" : 2276, "y" : 39 }, "type" : "ARROW", "centre" : { "x" : 2276, "y" : 39 } } }, { "edgeId" : 44658, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44651, "reactomeId" : 10255501, "displayName" : "SLC12A4,5,6,7", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2289, "y" : 141 }, "minX" : 2229, "maxX" : 2315, "minY" : 124, "maxY" : 159, "prop" : { "x" : 2264, "y" : 124, "width" : 51, "height" : 35 }, "textPosition" : { "x" : 2266, "y" : 117 }, "connectors" : [ { "edgeId" : 44648, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2258, "y" : 142 }, "to" : { "x" : 2237, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2233, "y" : 143 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2233, "y" : 143 } } } ] }, { "id" : 44653, "reactomeId" : 9941480, "displayName" : "SLC26A1,2 cargo", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 340, "y" : 674 }, "minX" : 174, "maxX" : 380, "minY" : 653, "maxY" : 692, "prop" : { "x" : 301, "y" : 657, "width" : 79, "height" : 35 }, "textPosition" : { "x" : 301, "y" : 657 }, "connectors" : [ { "edgeId" : 44652, "type" : "INPUT", "segments" : [ { "from" : { "x" : 295, "y" : 669 }, "to" : { "x" : 174, "y" : 653 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44654, "reactomeId" : 9941466, "displayName" : "SLC26A1,2 cargo", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 34, "y" : 664 }, "minX" : 0, "maxX" : 175, "minY" : 643, "maxY" : 686, "prop" : { "x" : 0, "y" : 643, "width" : 69, "height" : 43 }, "textPosition" : { "x" : 1, "y" : 647 }, "connectors" : [ { "edgeId" : 44652, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 75, "y" : 662 }, "to" : { "x" : 175, "y" : 657 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 82, "y" : 658 }, "b" : { "x" : 75, "y" : 662 }, "c" : { "x" : 82, "y" : 666 }, "type" : "ARROW", "centre" : { "x" : 82, "y" : 666 } } } ] }, { "id" : 44655, "reactomeId" : 10255668, "displayName" : "SLC26A1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 173, "y" : 733 }, "minX" : 133, "maxX" : 213, "minY" : 663, "maxY" : 746, "prop" : { "x" : 133, "y" : 721, "width" : 80, "height" : 25 }, "textPosition" : { "x" : 136, "y" : 723 }, "connectors" : [ { "edgeId" : 44652, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 173, "y" : 715 }, "to" : { "x" : 174, "y" : 671 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 175, "y" : 667 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 175, "y" : 667 } } } ] }, { "id" : 44657, "reactomeId" : 10255727, "displayName" : "SLC26A3,6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 949, "y" : 141 }, "minX" : 911, "maxX" : 1018, "minY" : 129, "maxY" : 154, "prop" : { "x" : 911, "y" : 129, "width" : 76, "height" : 25 }, "textPosition" : { "x" : 912, "y" : 131 }, "connectors" : [ { "edgeId" : 44656, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 993, "y" : 141 }, "to" : { "x" : 1010, "y" : 141 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1014, "y" : 141 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1014, "y" : 141 } } } ] }, { "id" : 44659, "reactomeId" : 10255681, "displayName" : "SLC26 chloride transporters", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2467, "y" : 144 }, "minX" : 2372, "maxX" : 2517, "minY" : 126, "maxY" : 163, "prop" : { "x" : 2417, "y" : 126, "width" : 100, "height" : 37 }, "textPosition" : { "x" : 2415, "y" : 127 }, "connectors" : [ { "edgeId" : 44658, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2411, "y" : 144 }, "to" : { "x" : 2380, "y" : 145 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2376, "y" : 145 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2376, "y" : 145 } } } ] }, { "id" : 44661, "reactomeId" : 209785, "displayName" : "I-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 793, "y" : 228 }, "minX" : 782, "maxX" : 806, "minY" : 144, "maxY" : 244, "prop" : { "x" : 782, "y" : 213, "width" : 23, "height" : 31 }, "textPosition" : { "x" : 786, "y" : 218 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 800, "y" : 218 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 800, "y" : 218 } } }, "connectors" : [ { "edgeId" : 44660, "type" : "INPUT", "segments" : [ { "from" : { "x" : 792, "y" : 210 }, "to" : { "x" : 792, "y" : 144 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44662, "reactomeId" : 209818, "displayName" : "I-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 792, "y" : 27 }, "minX" : 781, "maxX" : 805, "minY" : 11, "maxY" : 142, "prop" : { "x" : 781, "y" : 12, "width" : 23, "height" : 31 }, "textPosition" : { "x" : 785, "y" : 17 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 799, "y" : 17 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 799, "y" : 17 } } }, "connectors" : [ { "edgeId" : 44660, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 792, "y" : 46 }, "to" : { "x" : 792, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 796, "y" : 53 }, "b" : { "x" : 792, "y" : 46 }, "c" : { "x" : 788, "y" : 53 }, "type" : "ARROW", "centre" : { "x" : 788, "y" : 53 } } } ] }, { "id" : 44663, "reactomeId" : 10290616, "displayName" : "SLC26A4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 856, "y" : 142 }, "minX" : 800, "maxX" : 895, "minY" : 124, "maxY" : 155, "prop" : { "x" : 823, "y" : 130, "width" : 66, "height" : 25 }, "textPosition" : { "x" : 825, "y" : 132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 889, "y" : 130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 889, "y" : 130 } } }, "connectors" : [ { "edgeId" : 44660, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 820, "y" : 142 }, "to" : { "x" : 808, "y" : 142 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 804, "y" : 143 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 804, "y" : 143 } } } ] }, { "id" : 44665, "reactomeId" : 427648, "displayName" : "SO4(2-)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 57, "y" : 812 }, "minX" : 28, "maxX" : 87, "minY" : 796, "maxY" : 828, "prop" : { "x" : 28, "y" : 797, "width" : 58, "height" : 31 }, "textPosition" : { "x" : 29, "y" : 802 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 81, "y" : 802 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 81, "y" : 802 } } }, "connectors" : [ { "edgeId" : 44664, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44666, "reactomeId" : 174375, "displayName" : "SO4(2-)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 289, "y" : 814 }, "minX" : 260, "maxX" : 319, "minY" : 798, "maxY" : 830, "prop" : { "x" : 260, "y" : 799, "width" : 58, "height" : 31 }, "textPosition" : { "x" : 261, "y" : 804 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 313, "y" : 804 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 313, "y" : 804 } } }, "connectors" : [ { "edgeId" : 44664, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44667, "reactomeId" : 10310746, "displayName" : "SLC26A11", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 171, "y" : 866 }, "minX" : 137, "maxX" : 211, "minY" : 820, "maxY" : 878, "prop" : { "x" : 137, "y" : 855, "width" : 68, "height" : 23 }, "textPosition" : { "x" : 140, "y" : 849 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 205, "y" : 855 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 205, "y" : 855 } } }, "connectors" : [ { "edgeId" : 44664, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 171, "y" : 852 }, "to" : { "x" : 172, "y" : 828 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 172, "y" : 824 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 172, "y" : 824 } } } ] }, { "id" : 44669, "reactomeId" : 109277, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 360, "y" : 24 }, "minX" : 348, "maxX" : 403, "minY" : 8, "maxY" : 143, "prop" : { "x" : 348, "y" : 9, "width" : 25, "height" : 31 }, "textPosition" : { "x" : 351, "y" : 14 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 368, "y" : 14 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 368, "y" : 14 } } }, "connectors" : [ { "edgeId" : 44678, "type" : "INPUT", "segments" : [ { "from" : { "x" : 365, "y" : 43 }, "to" : { "x" : 403, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 44668, "type" : "INPUT", "segments" : [ { "from" : { "x" : 358, "y" : 43 }, "to" : { "x" : 348, "y" : 143 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 44670, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 367, "y" : 231 }, "minX" : 170, "maxX" : 403, "minY" : 143, "maxY" : 319, "prop" : { "x" : 355, "y" : 216, "width" : 25, "height" : 31 }, "textPosition" : { "x" : 358, "y" : 221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 375, "y" : 221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 375, "y" : 221 } } }, "connectors" : [ { "edgeId" : 44672, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 352, "y" : 236 }, "to" : { "x" : 170, "y" : 319 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 347, "y" : 243 }, "b" : { "x" : 352, "y" : 236 }, "c" : { "x" : 344, "y" : 235 }, "type" : "ARROW", "centre" : { "x" : 344, "y" : 235 } } }, { "edgeId" : 44675, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 352, "y" : 233 }, "to" : { "x" : 171, "y" : 277 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 346, "y" : 239 }, "b" : { "x" : 352, "y" : 233 }, "c" : { "x" : 344, "y" : 231 }, "type" : "ARROW", "centre" : { "x" : 344, "y" : 231 } } }, { "edgeId" : 44678, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 373, "y" : 213 }, "to" : { "x" : 403, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 372, "y" : 205 }, "b" : { "x" : 373, "y" : 213 }, "c" : { "x" : 379, "y" : 208 }, "type" : "ARROW", "centre" : { "x" : 379, "y" : 208 } } }, { "edgeId" : 44668, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 363, "y" : 213 }, "to" : { "x" : 348, "y" : 144 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 358, "y" : 207 }, "b" : { "x" : 363, "y" : 213 }, "c" : { "x" : 365, "y" : 205 }, "type" : "ARROW", "centre" : { "x" : 365, "y" : 205 } } } ] }, { "id" : 44671, "reactomeId" : 10255714, "displayName" : "SLC34A1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 267, "y" : 143 }, "minX" : 232, "maxX" : 340, "minY" : 132, "maxY" : 155, "prop" : { "x" : 232, "y" : 132, "width" : 71, "height" : 23 }, "textPosition" : { "x" : 234, "y" : 126 }, "connectors" : [ { "edgeId" : 44668, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 309, "y" : 143 }, "to" : { "x" : 332, "y" : 143 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 336, "y" : 143 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 336, "y" : 143 } } } ] } ], "edges" : [ { "id" : 44672, "reactomeId" : 10255704, "displayName" : "SLC34A3 cotransports Pi, 2Na+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 170, "y" : 319 }, "minX" : 165, "maxX" : 177, "minY" : 313, "maxY" : 325, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 171, "y" : 319 }, "to" : { "x" : 170, "y" : 319 } } ], "reactionShape" : { "a" : { "x" : 164, "y" : 313 }, "b" : { "x" : 176, "y" : 325 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 170, "y" : 319 } }, "inputs" : [ { "id" : 44597, "points" : [ { "x" : 62, "y" : 457 } ], "stoichiometry" : 2 }, { "id" : 44673, "points" : [ { "x" : 66, "y" : 309 } ] } ], "outputs" : [ { "id" : 44599, "points" : [ { "x" : 270, "y" : 452 } ], "stoichiometry" : 2 }, { "id" : 44670, "points" : [ { "x" : 352, "y" : 236 } ] } ], "catalysts" : [ { "id" : 44674, "points" : [ { "x" : 170, "y" : 389 } ] } ] }, { "id" : 44642, "reactomeId" : 10255476, "displayName" : "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2048, "y" : 144 }, "minX" : 2042, "maxX" : 2054, "minY" : 138, "maxY" : 150, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2047, "y" : 141 }, "to" : { "x" : 2048, "y" : 144 } }, { "from" : { "x" : 2048, "y" : 144 }, "to" : { "x" : 2048, "y" : 142 } } ], "reactionShape" : { "a" : { "x" : 2042, "y" : 138 }, "b" : { "x" : 2054, "y" : 150 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2048, "y" : 144 } }, "inputs" : [ { "id" : 44643, "points" : [ { "x" : 2131, "y" : 36 } ] }, { "id" : 44644, "points" : [ { "x" : 2055, "y" : 43 } ] }, { "id" : 44636, "points" : [ { "x" : 1807, "y" : 20 }, { "x" : 1965, "y" : 20 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 44645, "points" : [ { "x" : 2136, "y" : 222 } ] }, { "id" : 44646, "points" : [ { "x" : 2064, "y" : 213 } ] }, { "id" : 44637, "points" : [ { "x" : 1811, "y" : 229 }, { "x" : 1973, "y" : 229 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 44647, "points" : [ { "x" : 2096, "y" : 144 } ] } ] }, { "id" : 44610, "reactomeId" : 10256203, "displayName" : "Passive I- efflux mediated by SLC5A8", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 661, "y" : 143 }, "minX" : 589, "maxX" : 667, "minY" : 43, "maxY" : 217, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 599, "y" : 217 }, "to" : { "x" : 661, "y" : 143 } }, { "from" : { "x" : 661, "y" : 143 }, "to" : { "x" : 589, "y" : 43 } } ], "endShape" : { "a" : { "x" : 596, "y" : 46 }, "b" : { "x" : 589, "y" : 43 }, "c" : { "x" : 590, "y" : 51 }, "type" : "ARROW", "centre" : { "x" : 590, "y" : 51 } }, "reactionShape" : { "a" : { "x" : 655, "y" : 137 }, "b" : { "x" : 667, "y" : 149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 661, "y" : 143 } }, "inputs" : [ { "id" : 44607 } ], "outputs" : [ { "id" : 44605 } ], "catalysts" : [ { "id" : 44611, "points" : [ { "x" : 689, "y" : 142 } ] } ] }, { "id" : 44675, "reactomeId" : 10255697, "displayName" : "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 171, "y" : 277 }, "minX" : 165, "maxX" : 177, "minY" : 271, "maxY" : 283, "reactionType" : "transition", "segments" : [ ], "reactionShape" : { "a" : { "x" : 165, "y" : 271 }, "b" : { "x" : 177, "y" : 283 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 171, "y" : 277 } }, "inputs" : [ { "id" : 44676, "points" : [ { "x" : 71, "y" : 242 } ], "stoichiometry" : 2 }, { "id" : 44673, "points" : [ { "x" : 66, "y" : 304 } ] } ], "outputs" : [ { "id" : 44599, "points" : [ { "x" : 273, "y" : 452 } ], "stoichiometry" : 2 }, { "id" : 44670, "points" : [ { "x" : 352, "y" : 233 } ] } ], "catalysts" : [ { "id" : 44677, "points" : [ { "x" : 171, "y" : 225 } ] } ] }, { "id" : 44612, "reactomeId" : 10255304, "displayName" : "SLC4A1,2,3 exchanges HCO3- for Cl-", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1054, "y" : 142 }, "minX" : 1048, "maxX" : 1060, "minY" : 136, "maxY" : 148, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1054, "y" : 143 }, "to" : { "x" : 1054, "y" : 142 } } ], "reactionShape" : { "a" : { "x" : 1048, "y" : 136 }, "b" : { "x" : 1060, "y" : 148 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1054, "y" : 142 } }, "inputs" : [ { "id" : 44613, "points" : [ { "x" : 957, "y" : 43 } ] }, { "id" : 44614, "points" : [ { "x" : 1128, "y" : 217 } ] } ], "outputs" : [ { "id" : 44615, "points" : [ { "x" : 962, "y" : 215 } ] }, { "id" : 44616, "points" : [ { "x" : 1123, "y" : 37 } ] } ], "catalysts" : [ { "id" : 44617, "points" : [ { "x" : 1086, "y" : 142 } ] } ] }, { "id" : 44678, "reactomeId" : 10255963, "displayName" : "Type I Na+-coupled phosphate co-transport", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 401, "y" : 143 }, "minX" : 395, "maxX" : 407, "minY" : 137, "maxY" : 149, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 403, "y" : 143 }, "to" : { "x" : 401, "y" : 143 } }, { "from" : { "x" : 401, "y" : 143 }, "to" : { "x" : 403, "y" : 143 } } ], "reactionShape" : { "a" : { "x" : 395, "y" : 137 }, "b" : { "x" : 407, "y" : 149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 401, "y" : 143 } }, "inputs" : [ { "id" : 44669, "points" : [ { "x" : 365, "y" : 43 } ] }, { "id" : 44606, "points" : [ { "x" : 459, "y" : 46 } ] } ], "outputs" : [ { "id" : 44670, "points" : [ { "x" : 373, "y" : 213 } ] }, { "id" : 44608, "points" : [ { "x" : 462, "y" : 212 } ] } ], "catalysts" : [ { "id" : 44679, "points" : [ { "x" : 429, "y" : 142 } ] } ] }, { "id" : 44648, "reactomeId" : 10255504, "displayName" : "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2221, "y" : 144 }, "minX" : 2215, "maxX" : 2227, "minY" : 108, "maxY" : 208, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2221, "y" : 208 }, "to" : { "x" : 2221, "y" : 144 } }, { "from" : { "x" : 2221, "y" : 144 }, "to" : { "x" : 2221, "y" : 108 } } ], "reactionShape" : { "a" : { "x" : 2215, "y" : 138 }, "b" : { "x" : 2227, "y" : 150 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2221, "y" : 144 } }, "inputs" : [ { "id" : 44645, "points" : [ { "x" : 2172, "y" : 229 } ] }, { "id" : 44649, "points" : [ { "x" : 2277, "y" : 228 } ] } ], "outputs" : [ { "id" : 44643, "points" : [ { "x" : 2156, "y" : 36 } ] }, { "id" : 44650, "points" : [ { "x" : 2284, "y" : 36 } ] } ], "catalysts" : [ { "id" : 44651, "points" : [ { "x" : 2258, "y" : 142 } ] } ] }, { "id" : 44618, "reactomeId" : 10255321, "displayName" : "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1212, "y" : 143 }, "minX" : 1206, "maxX" : 1218, "minY" : 137, "maxY" : 149, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1211, "y" : 143 }, "to" : { "x" : 1212, "y" : 143 } }, { "from" : { "x" : 1212, "y" : 143 }, "to" : { "x" : 1210, "y" : 143 } } ], "reactionShape" : { "a" : { "x" : 1206, "y" : 137 }, "b" : { "x" : 1218, "y" : 149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1212, "y" : 143 } }, "inputs" : [ { "id" : 44614, "points" : [ { "x" : 1154, "y" : 217 } ], "stoichiometry" : 3 }, { "id" : 44619, "points" : [ { "x" : 1281, "y" : 208 } ] } ], "outputs" : [ { "id" : 44616, "points" : [ { "x" : 1142, "y" : 37 } ], "stoichiometry" : 3 }, { "id" : 44620, "points" : [ { "x" : 1277, "y" : 42 } ] } ], "catalysts" : [ { "id" : 44621, "points" : [ { "x" : 1257, "y" : 141 } ] } ] }, { "id" : 44652, "reactomeId" : 10255671, "displayName" : "SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 175, "y" : 655 }, "minX" : 169, "maxX" : 181, "minY" : 649, "maxY" : 661, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 174, "y" : 653 }, "to" : { "x" : 175, "y" : 655 } }, { "from" : { "x" : 175, "y" : 655 }, "to" : { "x" : 175, "y" : 657 } } ], "reactionShape" : { "a" : { "x" : 169, "y" : 649 }, "b" : { "x" : 181, "y" : 661 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 175, "y" : 655 } }, "inputs" : [ { "id" : 44653, "points" : [ { "x" : 295, "y" : 669 } ] }, { "id" : 44598, "points" : [ { "x" : 90, "y" : 606 } ] } ], "outputs" : [ { "id" : 44654, "points" : [ { "x" : 75, "y" : 662 } ] }, { "id" : 44600, "points" : [ { "x" : 258, "y" : 611 } ] } ], "catalysts" : [ { "id" : 44655, "points" : [ { "x" : 173, "y" : 715 } ] } ] }, { "id" : 44622, "reactomeId" : 10311230, "displayName" : "SLC4A4 cotransports Na+ with 3HCO3-", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1381, "y" : 143 }, "minX" : 1375, "maxX" : 1387, "minY" : 137, "maxY" : 149, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1382, "y" : 142 }, "to" : { "x" : 1381, "y" : 143 } }, { "from" : { "x" : 1381, "y" : 143 }, "to" : { "x" : 1382, "y" : 145 } } ], "reactionShape" : { "a" : { "x" : 1375, "y" : 137 }, "b" : { "x" : 1387, "y" : 149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1381, "y" : 143 } }, "inputs" : [ { "id" : 44619, "points" : [ { "x" : 1313, "y" : 208 } ] }, { "id" : 44623, "points" : [ { "x" : 1432, "y" : 209 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 44620, "points" : [ { "x" : 1299, "y" : 42 } ] }, { "id" : 44624, "points" : [ { "x" : 1417, "y" : 42 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 44625, "points" : [ { "x" : 1439, "y" : 141 } ] } ], "activators" : [ { "id" : 44626, "points" : [ { "x" : 1376, "y" : 235 } ] } ] }, { "id" : 44656, "reactomeId" : 10255730, "displayName" : "SLC26A3,6 exchange Cl- for HCO3-", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1026, "y" : 141 }, "minX" : 1020, "maxX" : 1032, "minY" : 135, "maxY" : 147, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1025, "y" : 141 }, "to" : { "x" : 1026, "y" : 141 } }, { "from" : { "x" : 1026, "y" : 141 }, "to" : { "x" : 1026, "y" : 142 } } ], "reactionShape" : { "a" : { "x" : 1020, "y" : 135 }, "b" : { "x" : 1032, "y" : 147 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1026, "y" : 141 } }, "inputs" : [ { "id" : 44613, "points" : [ { "x" : 953, "y" : 43 } ] }, { "id" : 44614, "points" : [ { "x" : 1123, "y" : 217 } ] } ], "outputs" : [ { "id" : 44615, "points" : [ { "x" : 957, "y" : 210 } ] }, { "id" : 44616, "points" : [ { "x" : 1119, "y" : 37 } ] } ], "catalysts" : [ { "id" : 44657, "points" : [ { "x" : 993, "y" : 141 } ] } ] }, { "id" : 44658, "reactomeId" : 10255684, "displayName" : "Group 3 - Selective Cl- transport", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2364, "y" : 145 }, "minX" : 2305, "maxX" : 2370, "minY" : 36, "maxY" : 216, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2305, "y" : 36 }, "to" : { "x" : 2364, "y" : 145 } }, { "from" : { "x" : 2364, "y" : 145 }, "to" : { "x" : 2307, "y" : 216 } } ], "endShape" : { "a" : { "x" : 2308, "y" : 208 }, "b" : { "x" : 2307, "y" : 216 }, "c" : { "x" : 2314, "y" : 213 }, "type" : "ARROW", "centre" : { "x" : 2314, "y" : 213 } }, "reactionShape" : { "a" : { "x" : 2358, "y" : 139 }, "b" : { "x" : 2370, "y" : 151 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2364, "y" : 145 } }, "inputs" : [ { "id" : 44650 } ], "outputs" : [ { "id" : 44649 } ], "catalysts" : [ { "id" : 44659, "points" : [ { "x" : 2411, "y" : 144 } ] } ] }, { "id" : 44627, "reactomeId" : 10255334, "displayName" : "Na+-driven Cl-/HCO3- exchanger transport", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1545, "y" : 142 }, "minX" : 1539, "maxX" : 1551, "minY" : 136, "maxY" : 148, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1545, "y" : 142 }, "to" : { "x" : 1545, "y" : 143 } } ], "reactionShape" : { "a" : { "x" : 1539, "y" : 136 }, "b" : { "x" : 1551, "y" : 148 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1545, "y" : 142 } }, "inputs" : [ { "id" : 44628, "points" : [ { "x" : 1604, "y" : 246 } ] }, { "id" : 44624, "points" : [ { "x" : 1438, "y" : 42 } ] }, { "id" : 44629, "points" : [ { "x" : 1546, "y" : 211 } ] }, { "id" : 44630, "points" : [ { "x" : 1649, "y" : 47 } ] } ], "outputs" : [ { "id" : 44631, "points" : [ { "x" : 1590, "y" : 37 } ] }, { "id" : 44623, "points" : [ { "x" : 1462, "y" : 209 } ] }, { "id" : 44632, "points" : [ { "x" : 1539, "y" : 35 } ] }, { "id" : 44633, "points" : [ { "x" : 1649, "y" : 217 } ] } ], "catalysts" : [ { "id" : 44634, "points" : [ { "x" : 1609, "y" : 142 } ] } ] }, { "id" : 44596, "reactomeId" : 10256890, "displayName" : "NaS1 co-transports sulphate and a sodium ion", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 171, "y" : 546 }, "minX" : 165, "maxX" : 177, "minY" : 540, "maxY" : 552, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 170, "y" : 548 }, "to" : { "x" : 171, "y" : 546 } }, { "from" : { "x" : 171, "y" : 546 }, "to" : { "x" : 172, "y" : 546 } } ], "reactionShape" : { "a" : { "x" : 165, "y" : 540 }, "b" : { "x" : 177, "y" : 552 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 171, "y" : 546 } }, "inputs" : [ { "id" : 44597, "points" : [ { "x" : 74, "y" : 486 } ] }, { "id" : 44598, "points" : [ { "x" : 90, "y" : 579 } ] } ], "outputs" : [ { "id" : 44599, "points" : [ { "x" : 260, "y" : 483 } ] }, { "id" : 44600, "points" : [ { "x" : 253, "y" : 580 } ] } ], "catalysts" : [ { "id" : 44601, "points" : [ { "x" : 171, "y" : 584 } ] } ] }, { "id" : 44660, "reactomeId" : 10290619, "displayName" : "SLC26A4 exports I- to follicular lumen", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 792, "y" : 143 }, "minX" : 786, "maxX" : 798, "minY" : 137, "maxY" : 149, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 792, "y" : 144 }, "to" : { "x" : 792, "y" : 143 } }, { "from" : { "x" : 792, "y" : 143 }, "to" : { "x" : 792, "y" : 142 } } ], "reactionShape" : { "a" : { "x" : 786, "y" : 137 }, "b" : { "x" : 798, "y" : 149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 792, "y" : 143 } }, "inputs" : [ { "id" : 44613, "points" : [ { "x" : 924, "y" : 37 } ] }, { "id" : 44661, "points" : [ { "x" : 792, "y" : 210 } ] } ], "outputs" : [ { "id" : 44615, "points" : [ { "x" : 923, "y" : 218 } ] }, { "id" : 44662, "points" : [ { "x" : 792, "y" : 46 } ] } ], "catalysts" : [ { "id" : 44663, "points" : [ { "x" : 820, "y" : 142 } ] } ] }, { "id" : 44664, "reactomeId" : 10310749, "displayName" : "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 173, "y" : 812 }, "minX" : 89, "maxX" : 257, "minY" : 806, "maxY" : 818, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 89, "y" : 812 }, "to" : { "x" : 173, "y" : 812 } }, { "from" : { "x" : 173, "y" : 812 }, "to" : { "x" : 257, "y" : 813 } } ], "endShape" : { "a" : { "x" : 250, "y" : 817 }, "b" : { "x" : 257, "y" : 813 }, "c" : { "x" : 250, "y" : 809 }, "type" : "ARROW", "centre" : { "x" : 250, "y" : 809 } }, "reactionShape" : { "a" : { "x" : 167, "y" : 806 }, "b" : { "x" : 179, "y" : 818 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 173, "y" : 812 } }, "inputs" : [ { "id" : 44665 } ], "outputs" : [ { "id" : 44666 } ], "catalysts" : [ { "id" : 44667, "points" : [ { "x" : 171, "y" : 852 } ] } ] }, { "id" : 44602, "reactomeId" : 10256869, "displayName" : "NaS2 co-transports sulphate and two sodium ions", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 170, "y" : 498 }, "minX" : 164, "maxX" : 176, "minY" : 492, "maxY" : 504, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 171, "y" : 498 }, "to" : { "x" : 170, "y" : 498 } }, { "from" : { "x" : 170, "y" : 498 }, "to" : { "x" : 170, "y" : 500 } } ], "reactionShape" : { "a" : { "x" : 164, "y" : 492 }, "b" : { "x" : 176, "y" : 504 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 170, "y" : 498 } }, "inputs" : [ { "id" : 44597, "points" : [ { "x" : 74, "y" : 478 } ], "stoichiometry" : 2 }, { "id" : 44598, "points" : [ { "x" : 76, "y" : 573 } ] } ], "outputs" : [ { "id" : 44600, "points" : [ { "x" : 265, "y" : 574 } ] }, { "id" : 44599, "points" : [ { "x" : 260, "y" : 475 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 44603, "points" : [ { "x" : 170, "y" : 452 } ] } ] }, { "id" : 44635, "reactomeId" : 10255483, "displayName" : "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1790, "y" : 144 }, "minX" : 1784, "maxX" : 1796, "minY" : 138, "maxY" : 150, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1788, "y" : 143 }, "to" : { "x" : 1790, "y" : 144 } }, { "from" : { "x" : 1790, "y" : 144 }, "to" : { "x" : 1793, "y" : 147 } } ], "reactionShape" : { "a" : { "x" : 1784, "y" : 138 }, "b" : { "x" : 1796, "y" : 150 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1790, "y" : 144 } }, "inputs" : [ { "id" : 44630, "points" : [ { "x" : 1682, "y" : 47 } ] }, { "id" : 44636, "points" : [ { "x" : 1787, "y" : 39 } ] } ], "outputs" : [ { "id" : 44633, "points" : [ { "x" : 1694, "y" : 217 } ] }, { "id" : 44637, "points" : [ { "x" : 1791, "y" : 212 } ] } ], "catalysts" : [ { "id" : 44638, "points" : [ { "x" : 1832, "y" : 144 } ] } ] }, { "id" : 44604, "reactomeId" : 10256146, "displayName" : "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 525, "y" : 142 }, "minX" : 519, "maxX" : 531, "minY" : 136, "maxY" : 148, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 525, "y" : 142 }, "to" : { "x" : 525, "y" : 143 } } ], "reactionShape" : { "a" : { "x" : 519, "y" : 136 }, "b" : { "x" : 531, "y" : 148 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 525, "y" : 142 } }, "inputs" : [ { "id" : 44605, "points" : [ { "x" : 567, "y" : 47 } ] }, { "id" : 44606, "points" : [ { "x" : 475, "y" : 46 } ] } ], "outputs" : [ { "id" : 44607, "points" : [ { "x" : 573, "y" : 213 } ] }, { "id" : 44608, "points" : [ { "x" : 484, "y" : 212 } ] } ], "catalysts" : [ { "id" : 44609, "points" : [ { "x" : 567, "y" : 143 } ] } ] }, { "id" : 44668, "reactomeId" : 10255717, "displayName" : "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 348, "y" : 143 }, "minX" : 342, "maxX" : 354, "minY" : 137, "maxY" : 149, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 348, "y" : 143 }, "to" : { "x" : 348, "y" : 144 } } ], "reactionShape" : { "a" : { "x" : 342, "y" : 137 }, "b" : { "x" : 354, "y" : 149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 348, "y" : 143 } }, "inputs" : [ { "id" : 44669, "points" : [ { "x" : 358, "y" : 43 } ] }, { "id" : 44606, "points" : [ { "x" : 451, "y" : 46 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 44670, "points" : [ { "x" : 363, "y" : 213 } ] }, { "id" : 44608, "points" : [ { "x" : 454, "y" : 216 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 44671, "points" : [ { "x" : 309, "y" : 143 } ] } ] }, { "id" : 44639, "reactomeId" : 10321742, "displayName" : "SLC12A3 binds SLC12A3 inhibitors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1913, "y" : 113 }, "minX" : 1907, "maxX" : 1937, "minY" : 107, "maxY" : 126, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1912, "y" : 112 }, "to" : { "x" : 1913, "y" : 113 } }, { "from" : { "x" : 1913, "y" : 113 }, "to" : { "x" : 1937, "y" : 126 } } ], "endShape" : { "a" : { "x" : 1929, "y" : 126 }, "b" : { "x" : 1937, "y" : 126 }, "c" : { "x" : 1933, "y" : 119 }, "type" : "ARROW", "centre" : { "x" : 1933, "y" : 119 } }, "reactionShape" : { "c" : { "x" : 1913, "y" : 113 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1913, "y" : 113 } }, "inputs" : [ { "id" : 44638, "points" : [ { "x" : 1885, "y" : 130 } ] }, { "id" : 44640, "points" : [ { "x" : 1877, "y" : 77 } ] } ], "outputs" : [ { "id" : 44641 } ] } ], "compartments" : [ { "id" : 44680, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1314, "y" : 604 }, "minX" : 166, "maxX" : 2463, "minY" : 138, "maxY" : 1071, "prop" : { "x" : 166, "y" : 138, "width" : 2297, "height" : 933 }, "textPosition" : { "x" : 733, "y" : 407 }, "insets" : { "x" : 176, "y" : 148, "width" : 2277, "height" : 913 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 44600, 44599, 44601, 44596, 44602, 44603, 44670, 44679, 44608, 44607, 44609, 44604, 44610, 44611, 44612, 44614, 44617, 44618, 44621, 44619, 44626, 44625, 44622, 44623, 44628, 44634, 44633, 44627, 44635, 44638, 44615, 44629, 44637, 44641, 44642, 44645, 44647, 44646, 44651, 44649, 44648, 44652, 44653, 44655, 44657, 44656, 44659, 44658, 44661, 44660, 44663, 44666, 44664, 44667, 44671, 44668, 44674, 44672, 44677, 44675, 44678 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 44681, "reactomeId" : 10330293, "displayName" : "Bicarbonate transporters", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1328, "y" : 140 }, "minX" : 916, "maxX" : 1741, "minY" : -9, "maxY" : 290, "prop" : { "x" : 916, "y" : -9, "width" : 825, "height" : 299 }, "points" : [ { "x" : 916, "y" : -9 }, { "x" : 1741, "y" : -9 }, { "x" : 1741, "y" : 290 }, { "x" : 916, "y" : 290 } ], "colour" : "#4684ee" }, { "id" : 44682, "reactomeId" : 10330305, "displayName" : "Cation-coupled Chloride cotransporters", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1981, "y" : 127 }, "minX" : 1637, "maxX" : 2325, "minY" : -8, "maxY" : 262, "prop" : { "x" : 1741, "y" : -8, "width" : 584, "height" : 270 }, "points" : [ { "x" : 1637, "y" : -8 }, { "x" : 2325, "y" : -8 }, { "x" : 2325, "y" : 262 }, { "x" : 1637, "y" : 262 } ], "colour" : "#dc3912" }, { "id" : 44683, "reactomeId" : 10330317, "displayName" : "Inorganic anion exchange by SLC26 transporters", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1258, "y" : 440 }, "minX" : -10, "maxX" : 2527, "minY" : -8, "maxY" : 888, "prop" : { "x" : -10, "y" : 624, "width" : 2537, "height" : 264 }, "points" : [ { "x" : -10, "y" : -8 }, { "x" : 2527, "y" : -8 }, { "x" : 2527, "y" : 888 }, { "x" : -10, "y" : 888 } ], "colour" : "#008000" }, { "id" : 44684, "reactomeId" : 10330319, "displayName" : "Sodium-coupled phosphate cotransporters", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 264, "y" : 250 }, "minX" : 19, "maxX" : 509, "minY" : -1, "maxY" : 501, "prop" : { "x" : 19, "y" : -1, "width" : 490, "height" : 415 }, "points" : [ { "x" : 19, "y" : -1 }, { "x" : 509, "y" : -1 }, { "x" : 509, "y" : 501 }, { "x" : 19, "y" : 501 } ], "colour" : "#666666" }, { "id" : 44685, "reactomeId" : 10330365, "displayName" : "Sodium-coupled sulphate, di- and tri-carboxylate transporters", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 171, "y" : 519 }, "minX" : 19, "maxX" : 324, "minY" : 414, "maxY" : 624, "prop" : { "x" : 19, "y" : 501, "width" : 305, "height" : 123 }, "points" : [ { "x" : 19, "y" : 414 }, { "x" : 324, "y" : 414 }, { "x" : 324, "y" : 624 }, { "x" : 19, "y" : 624 } ], "colour" : "#4942cc" } ], "minX" : 0, "maxX" : 2517, "minY" : 0, "maxY" : 1071, "disease" : false }