{ "dbId" : 10329871, "stableId" : "R-CFA-5621481", "displayName" : "C-type lectin receptors (CLRs)", "nodes" : [ { "id" : 99072, "reactomeId" : 10288921, "displayName" : "Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2584, "y" : 537 }, "minX" : 2450, "maxX" : 2652, "minY" : 499, "maxY" : 666, "prop" : { "x" : 2522, "y" : 512, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 2524, "y" : 513 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2646, "y" : 512 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2646, "y" : 512 } } }, "connectors" : [ { "edgeId" : 99073, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2564, "y" : 509 }, "to" : { "x" : 2555, "y" : 499 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99069, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2558, "y" : 565 }, "to" : { "x" : 2450, "y" : 666 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2556, "y" : 573 }, "b" : { "x" : 2558, "y" : 565 }, "c" : { "x" : 2550, "y" : 567 }, "type" : "ARROW", "centre" : { "x" : 2550, "y" : 567 } } } ] }, { "id" : 99075, "reactomeId" : 10288923, "displayName" : "Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2406, "y" : 499 }, "minX" : 2221, "maxX" : 2477, "minY" : 461, "maxY" : 531, "prop" : { "x" : 2341, "y" : 467, "width" : 130, "height" : 64 }, "textPosition" : { "x" : 2344, "y" : 468 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2471, "y" : 467 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2471, "y" : 467 } } }, "connectors" : [ { "edgeId" : 99073, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99076, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2338, "y" : 497 }, "to" : { "x" : 2298, "y" : 497 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99076, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2338, "y" : 520 }, "to" : { "x" : 2312, "y" : 530 } }, { "from" : { "x" : 2312, "y" : 530 }, "to" : { "x" : 2224, "y" : 530 } }, { "from" : { "x" : 2224, "y" : 530 }, "to" : { "x" : 2225, "y" : 513 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2225, "y" : 509 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2225, "y" : 509 } } } ] }, { "id" : 99074, "reactomeId" : 10265580, "displayName" : "CUL1:FBXW11:SKP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2575, "y" : 476 }, "minX" : 2184, "maxX" : 2631, "minY" : 404, "maxY" : 499, "prop" : { "x" : 2526, "y" : 465, "width" : 99, "height" : 22 }, "textPosition" : { "x" : 2527, "y" : 452 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2625, "y" : 465 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2625, "y" : 465 } } }, "connectors" : [ { "edgeId" : 99073, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2565, "y" : 490 }, "to" : { "x" : 2555, "y" : 499 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99076, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2565, "y" : 462 }, "to" : { "x" : 2510, "y" : 404 } }, { "from" : { "x" : 2510, "y" : 404 }, "to" : { "x" : 2203, "y" : 404 } }, { "from" : { "x" : 2203, "y" : 404 }, "to" : { "x" : 2184, "y" : 497 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2557, "y" : 460 }, "b" : { "x" : 2565, "y" : 462 }, "c" : { "x" : 2563, "y" : 454 }, "type" : "ARROW", "centre" : { "x" : 2563, "y" : 454 } } } ] }, { "id" : 99077, "reactomeId" : 10284783, "displayName" : "UBE2M", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2218, "y" : 574 }, "minX" : 2154, "maxX" : 2303, "minY" : 497, "maxY" : 592, "prop" : { "x" : 2154, "y" : 556, "width" : 129, "height" : 36 }, "textPosition" : { "x" : 2193, "y" : 563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2283, "y" : 556 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2283, "y" : 556 } } }, "connectors" : [ { "edgeId" : 99076, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2286, "y" : 574 }, "to" : { "x" : 2303, "y" : 574 } }, { "from" : { "x" : 2303, "y" : 574 }, "to" : { "x" : 2298, "y" : 497 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99076, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2210, "y" : 553 }, "to" : { "x" : 2184, "y" : 497 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2203, "y" : 548 }, "b" : { "x" : 2210, "y" : 553 }, "c" : { "x" : 2211, "y" : 545 }, "type" : "ARROW", "centre" : { "x" : 2211, "y" : 545 } } } ] }, { "id" : 99079, "reactomeId" : 10261374, "displayName" : "K48-Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2360, "y" : 439 }, "minX" : 2298, "maxX" : 2412, "minY" : 428, "maxY" : 497, "prop" : { "x" : 2309, "y" : 428, "width" : 103, "height" : 23 }, "textPosition" : { "x" : 2334, "y" : 429 }, "connectors" : [ { "edgeId" : 99076, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2347, "y" : 457 }, "to" : { "x" : 2298, "y" : 497 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 2316, "y" : 471 }, "b" : { "x" : 2328, "y" : 483 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2322, "y" : 477 } } } } ] }, { "id" : 99078, "reactomeId" : 10264297, "displayName" : "UBA3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2238, "y" : 438 }, "minX" : 2184, "maxX" : 2298, "minY" : 421, "maxY" : 497, "prop" : { "x" : 2217, "y" : 427, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 2217, "y" : 427 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2259, "y" : 427 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2259, "y" : 427 } } }, "connectors" : [ { "edgeId" : 99076, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2249, "y" : 452 }, "to" : { "x" : 2298, "y" : 497 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99076, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2227, "y" : 452 }, "to" : { "x" : 2184, "y" : 497 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2225, "y" : 460 }, "b" : { "x" : 2227, "y" : 452 }, "c" : { "x" : 2219, "y" : 454 }, "type" : "ARROW", "centre" : { "x" : 2219, "y" : 454 } } } ] }, { "id" : 99080, "reactomeId" : 10288930, "displayName" : "K48-polyUb-p-7S-p100:RELB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2076, "y" : 498 }, "minX" : 2015, "maxX" : 2184, "minY" : 474, "maxY" : 516, "prop" : { "x" : 2015, "y" : 480, "width" : 123, "height" : 36 }, "textPosition" : { "x" : 2020, "y" : 481 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2138, "y" : 480 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2138, "y" : 480 } } }, "connectors" : [ { "edgeId" : 99076, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2141, "y" : 497 }, "to" : { "x" : 2184, "y" : 497 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2148, "y" : 493 }, "b" : { "x" : 2141, "y" : 497 }, "c" : { "x" : 2148, "y" : 501 }, "type" : "ARROW", "centre" : { "x" : 2148, "y" : 501 } } }, { "edgeId" : 99081, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99083, "reactomeId" : 10288938, "displayName" : "p52:RELB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1870, "y" : 549 }, "minX" : 1837, "maxX" : 1927, "minY" : 497, "maxY" : 560, "prop" : { "x" : 1837, "y" : 538, "width" : 67, "height" : 22 }, "textPosition" : { "x" : 1837, "y" : 539 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1904, "y" : 538 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1904, "y" : 538 } } }, "connectors" : [ { "edgeId" : 99081, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1882, "y" : 535 }, "to" : { "x" : 1927, "y" : 497 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1885, "y" : 527 }, "b" : { "x" : 1882, "y" : 535 }, "c" : { "x" : 1890, "y" : 534 }, "type" : "ARROW", "centre" : { "x" : 1890, "y" : 534 } } }, { "edgeId" : 99085, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99082, "reactomeId" : 10226816, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1862, "y" : 464 }, "minX" : 1850, "maxX" : 1927, "minY" : 453, "maxY" : 497, "prop" : { "x" : 1850, "y" : 453, "width" : 25, "height" : 22 }, "textPosition" : { "x" : 1850, "y" : 453 }, "connectors" : [ { "edgeId" : 99081, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1881, "y" : 470 }, "to" : { "x" : 1927, "y" : 497 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1898, "y" : 477 }, "b" : { "x" : 1910, "y" : 489 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1904, "y" : 483 } } }, "endShape" : { "a" : { "x" : 1889, "y" : 470 }, "b" : { "x" : 1881, "y" : 470 }, "c" : { "x" : 1885, "y" : 477 }, "type" : "ARROW", "centre" : { "x" : 1885, "y" : 477 } } } ] }, { "id" : 99084, "reactomeId" : 10226918, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1973, "y" : 417 }, "minX" : 1917, "maxX" : 2036, "minY" : 400, "maxY" : 489, "prop" : { "x" : 1917, "y" : 406, "width" : 113, "height" : 22 }, "textPosition" : { "x" : 1917, "y" : 407 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2030, "y" : 406 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2030, "y" : 406 } } }, "connectors" : [ { "edgeId" : 99081, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1972, "y" : 431 }, "to" : { "x" : 1972, "y" : 481 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1972, "y" : 485 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1972, "y" : 485 } } } ] }, { "id" : 99086, "reactomeId" : 10289004, "displayName" : "p52:RELB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1646, "y" : 851 }, "minX" : 1613, "maxX" : 1686, "minY" : 834, "maxY" : 862, "prop" : { "x" : 1613, "y" : 840, "width" : 67, "height" : 22 }, "textPosition" : { "x" : 1613, "y" : 841 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1680, "y" : 840 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1680, "y" : 840 } } }, "connectors" : [ { "edgeId" : 99085, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99089, "reactomeId" : 10238488, "displayName" : "UBE2N:UBE2V1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3170, "y" : 365 }, "minX" : 3119, "maxX" : 3227, "minY" : 349, "maxY" : 415, "prop" : { "x" : 3119, "y" : 355, "width" : 102, "height" : 21 }, "textPosition" : { "x" : 3141, "y" : 341 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3221, "y" : 355 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3221, "y" : 355 } } }, "connectors" : [ { "edgeId" : 99087, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3178, "y" : 379 }, "to" : { "x" : 3209, "y" : 415 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99087, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3162, "y" : 379 }, "to" : { "x" : 3133, "y" : 415 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3161, "y" : 387 }, "b" : { "x" : 3162, "y" : 379 }, "c" : { "x" : 3155, "y" : 382 }, "type" : "ARROW", "centre" : { "x" : 3155, "y" : 382 } } } ] }, { "id" : 99088, "reactomeId" : 10238454, "displayName" : "K63polyUb", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 3248, "y" : 467 }, "minX" : 3209, "maxX" : 3287, "minY" : 415, "maxY" : 479, "prop" : { "x" : 3210, "y" : 456, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 3212, "y" : 457 }, "connectors" : [ { "edgeId" : 99087, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3239, "y" : 453 }, "to" : { "x" : 3209, "y" : 415 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99091, "reactomeId" : 10245355, "displayName" : "Ub-TRAF6 trimer bound to CBM complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3178, "y" : 580 }, "minX" : 3123, "maxX" : 3239, "minY" : 423, "maxY" : 604, "prop" : { "x" : 3123, "y" : 556, "width" : 110, "height" : 48 }, "textPosition" : { "x" : 3122, "y" : 555 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3233, "y" : 556 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3233, "y" : 556 } } }, "connectors" : [ { "edgeId" : 99087, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3177, "y" : 553 }, "to" : { "x" : 3176, "y" : 431 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3176, "y" : 427 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3176, "y" : 427 } } } ] }, { "id" : 99090, "reactomeId" : 10245412, "displayName" : "CHUK:p-S177,S181-IKBKB:pUb-IKBKG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3022, "y" : 417 }, "minX" : 2958, "maxX" : 3133, "minY" : 392, "maxY" : 436, "prop" : { "x" : 2958, "y" : 398, "width" : 129, "height" : 38 }, "textPosition" : { "x" : 2958, "y" : 401 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3087, "y" : 398 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3087, "y" : 398 } } }, "connectors" : [ { "edgeId" : 99087, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3090, "y" : 415 }, "to" : { "x" : 3133, "y" : 415 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3097, "y" : 411 }, "b" : { "x" : 3090, "y" : 415 }, "c" : { "x" : 3097, "y" : 419 }, "type" : "ARROW", "centre" : { "x" : 3097, "y" : 419 } } } ] }, { "id" : 99093, "reactomeId" : 9038391, "displayName" : "TDM,alpha-mannan", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 450, "y" : 1431 }, "minX" : 388, "maxX" : 513, "minY" : 1352, "maxY" : 1442, "prop" : { "x" : 388, "y" : 1420, "width" : 125, "height" : 22 }, "textPosition" : { "x" : 412, "y" : 1414 }, "connectors" : [ { "edgeId" : 99092, "type" : "INPUT", "segments" : [ { "from" : { "x" : 444, "y" : 1414 }, "to" : { "x" : 414, "y" : 1352 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99095, "reactomeId" : 10289663, "displayName" : "CLEC4E:FCER1G dimer:TDM,alpha-mannan", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 301, "y" : 1354 }, "minX" : 243, "maxX" : 366, "minY" : 1323, "maxY" : 1379, "prop" : { "x" : 243, "y" : 1329, "width" : 117, "height" : 50 }, "textPosition" : { "x" : 243, "y" : 1330 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 360, "y" : 1329 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 360, "y" : 1329 } } }, "connectors" : [ { "edgeId" : 99092, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99094, "reactomeId" : 10289661, "displayName" : "CLEC4E:FCER1G dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 490, "y" : 1352 }, "minX" : 414, "maxX" : 550, "minY" : 1328, "maxY" : 1370, "prop" : { "x" : 437, "y" : 1334, "width" : 107, "height" : 36 }, "textPosition" : { "x" : 436, "y" : 1335 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 544, "y" : 1334 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 544, "y" : 1334 } } }, "connectors" : [ { "edgeId" : 99092, "type" : "INPUT", "segments" : [ { "from" : { "x" : 434, "y" : 1352 }, "to" : { "x" : 414, "y" : 1352 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99097, "reactomeId" : 10289663, "displayName" : "CLEC4E:FCER1G dimer:TDM,alpha-mannan", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 181, "y" : 1124 }, "minX" : 120, "maxX" : 248, "minY" : 1065, "maxY" : 1149, "prop" : { "x" : 120, "y" : 1099, "width" : 122, "height" : 50 }, "textPosition" : { "x" : 123, "y" : 1099 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 242, "y" : 1099 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 242, "y" : 1099 } } }, "connectors" : [ { "edgeId" : 99096, "type" : "INPUT", "segments" : [ { "from" : { "x" : 188, "y" : 1093 }, "to" : { "x" : 199, "y" : 1065 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99099, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 295, "y" : 978 }, "minX" : 199, "maxX" : 317, "minY" : 962, "maxY" : 1003, "prop" : { "x" : 275, "y" : 963, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 279, "y" : 967 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 311, "y" : 968 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 311, "y" : 968 } } }, "connectors" : [ { "edgeId" : 99096, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 272, "y" : 983 }, "to" : { "x" : 199, "y" : 1003 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 229, "y" : 987 }, "b" : { "x" : 241, "y" : 999 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 235, "y" : 993 } } }, "endShape" : { "a" : { "x" : 266, "y" : 989 }, "b" : { "x" : 272, "y" : 983 }, "c" : { "x" : 264, "y" : 981 }, "type" : "ARROW", "centre" : { "x" : 264, "y" : 981 } } } ] }, { "id" : 99098, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 295, "y" : 1073 }, "minX" : 199, "maxX" : 316, "minY" : 1057, "maxY" : 1088, "prop" : { "x" : 275, "y" : 1058, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 279, "y" : 1062 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 1063 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 1063 } } }, "connectors" : [ { "edgeId" : 99096, "type" : "INPUT", "segments" : [ { "from" : { "x" : 272, "y" : 1071 }, "to" : { "x" : 199, "y" : 1065 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 229, "y" : 1062 }, "b" : { "x" : 241, "y" : 1074 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 235, "y" : 1068 } } } } ] }, { "id" : 99101, "reactomeId" : 10289667, "displayName" : "FYN, LYN", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 269, "y" : 1028 }, "minX" : 185, "maxX" : 300, "minY" : 1017, "maxY" : 1039, "prop" : { "x" : 239, "y" : 1017, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 239, "y" : 1017 }, "connectors" : [ { "edgeId" : 99096, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 233, "y" : 1028 }, "to" : { "x" : 193, "y" : 1029 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 189, "y" : 1029 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 189, "y" : 1029 } } } ] }, { "id" : 99100, "reactomeId" : 10289643, "displayName" : "CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 180, "y" : 938 }, "minX" : 115, "maxX" : 252, "minY" : 885, "maxY" : 1003, "prop" : { "x" : 115, "y" : 913, "width" : 131, "height" : 50 }, "textPosition" : { "x" : 116, "y" : 913 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 246, "y" : 913 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 246, "y" : 913 } } }, "connectors" : [ { "edgeId" : 99096, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 187, "y" : 969 }, "to" : { "x" : 199, "y" : 1003 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 193, "y" : 974 }, "b" : { "x" : 187, "y" : 969 }, "c" : { "x" : 186, "y" : 977 }, "type" : "ARROW", "centre" : { "x" : 186, "y" : 977 } } }, { "edgeId" : 99102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 193, "y" : 907 }, "to" : { "x" : 208, "y" : 885 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99103, "reactomeId" : 10235016, "displayName" : "SYK", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 295, "y" : 885 }, "minX" : 208, "maxX" : 316, "minY" : 868, "maxY" : 896, "prop" : { "x" : 280, "y" : 874, "width" : 30, "height" : 22 }, "textPosition" : { "x" : 280, "y" : 874 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 874 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 874 } } }, "connectors" : [ { "edgeId" : 99102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 277, "y" : 885 }, "to" : { "x" : 208, "y" : 885 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99104, "reactomeId" : 10289677, "displayName" : "pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 173, "y" : 784 }, "minX" : 108, "maxX" : 245, "minY" : 701, "maxY" : 809, "prop" : { "x" : 108, "y" : 759, "width" : 131, "height" : 50 }, "textPosition" : { "x" : 108, "y" : 760 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 239, "y" : 759 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 239, "y" : 759 } } }, "connectors" : [ { "edgeId" : 99102, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99105, "type" : "INPUT", "segments" : [ { "from" : { "x" : 193, "y" : 756 }, "to" : { "x" : 213, "y" : 734 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99105, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 172, "y" : 756 }, "to" : { "x" : 172, "y" : 704 } }, { "from" : { "x" : 172, "y" : 704 }, "to" : { "x" : 185, "y" : 704 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 189, "y" : 705 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 189, "y" : 705 } } } ] }, { "id" : 99107, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 295, "y" : 662 }, "minX" : 213, "maxX" : 317, "minY" : 646, "maxY" : 678, "prop" : { "x" : 275, "y" : 647, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 279, "y" : 651 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 311, "y" : 652 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 311, "y" : 652 } } }, "connectors" : [ { "edgeId" : 99105, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 272, "y" : 666 }, "to" : { "x" : 213, "y" : 678 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 236, "y" : 666 }, "b" : { "x" : 248, "y" : 678 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 242, "y" : 672 } } }, "endShape" : { "a" : { "x" : 266, "y" : 671 }, "b" : { "x" : 272, "y" : 666 }, "c" : { "x" : 264, "y" : 663 }, "type" : "ARROW", "centre" : { "x" : 264, "y" : 663 } } } ] }, { "id" : 99106, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 295, "y" : 744 }, "minX" : 213, "maxX" : 316, "minY" : 728, "maxY" : 759, "prop" : { "x" : 275, "y" : 729, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 279, "y" : 733 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 734 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 734 } } }, "connectors" : [ { "edgeId" : 99105, "type" : "INPUT", "segments" : [ { "from" : { "x" : 272, "y" : 741 }, "to" : { "x" : 213, "y" : 734 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 236, "y" : 731 }, "b" : { "x" : 248, "y" : 743 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 242, "y" : 737 } } } } ] }, { "id" : 99108, "reactomeId" : 10289645, "displayName" : "pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 179, "y" : 616 }, "minX" : 115, "maxX" : 449, "minY" : 283, "maxY" : 678, "prop" : { "x" : 115, "y" : 584, "width" : 129, "height" : 64 }, "textPosition" : { "x" : 119, "y" : 585 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 244, "y" : 584 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 244, "y" : 584 } } }, "connectors" : [ { "edgeId" : 99105, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 196, "y" : 651 }, "to" : { "x" : 213, "y" : 678 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 203, "y" : 655 }, "b" : { "x" : 196, "y" : 651 }, "c" : { "x" : 196, "y" : 659 }, "type" : "ARROW", "centre" : { "x" : 196, "y" : 659 } } }, { "edgeId" : 99114, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 247, "y" : 616 }, "to" : { "x" : 366, "y" : 616 } }, { "from" : { "x" : 366, "y" : 616 }, "to" : { "x" : 449, "y" : 283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 254, "y" : 612 }, "b" : { "x" : 247, "y" : 616 }, "c" : { "x" : 254, "y" : 620 }, "type" : "ARROW", "centre" : { "x" : 254, "y" : 620 } } } ] }, { "id" : 99111, "reactomeId" : 10289672, "displayName" : "pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 174, "y" : 446 }, "minX" : 109, "maxX" : 246, "minY" : 364, "maxY" : 478, "prop" : { "x" : 109, "y" : 414, "width" : 131, "height" : 64 }, "textPosition" : { "x" : 109, "y" : 415 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 240, "y" : 414 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 240, "y" : 414 } } }, "connectors" : [ { "edgeId" : 99109, "type" : "INPUT", "segments" : [ { "from" : { "x" : 201, "y" : 411 }, "to" : { "x" : 224, "y" : 387 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99109, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 174, "y" : 411 }, "to" : { "x" : 174, "y" : 368 } }, { "from" : { "x" : 174, "y" : 368 }, "to" : { "x" : 185, "y" : 368 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 189, "y" : 368 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 189, "y" : 368 } } } ] }, { "id" : 99110, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 295, "y" : 426 }, "minX" : 224, "maxX" : 316, "minY" : 387, "maxY" : 441, "prop" : { "x" : 275, "y" : 411, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 279, "y" : 415 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 416 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 416 } } }, "connectors" : [ { "edgeId" : 99109, "type" : "INPUT", "segments" : [ { "from" : { "x" : 272, "y" : 415 }, "to" : { "x" : 224, "y" : 387 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 242, "y" : 395 }, "b" : { "x" : 254, "y" : 407 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 248, "y" : 401 } } } } ] }, { "id" : 99113, "reactomeId" : 10289647, "displayName" : "pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 171, "y" : 283 }, "minX" : 107, "maxX" : 242, "minY" : 238, "maxY" : 347, "prop" : { "x" : 107, "y" : 244, "width" : 129, "height" : 78 }, "textPosition" : { "x" : 111, "y" : 245 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 236, "y" : 244 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 236, "y" : 244 } } }, "connectors" : [ { "edgeId" : 99109, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 203, "y" : 325 }, "to" : { "x" : 224, "y" : 347 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 211, "y" : 327 }, "b" : { "x" : 203, "y" : 325 }, "c" : { "x" : 205, "y" : 333 }, "type" : "ARROW", "centre" : { "x" : 205, "y" : 333 } } }, { "edgeId" : 99114, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99112, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 295, "y" : 332 }, "minX" : 224, "maxX" : 317, "minY" : 316, "maxY" : 347, "prop" : { "x" : 275, "y" : 317, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 279, "y" : 321 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 311, "y" : 322 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 311, "y" : 322 } } }, "connectors" : [ { "edgeId" : 99109, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 272, "y" : 336 }, "to" : { "x" : 224, "y" : 347 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 242, "y" : 335 }, "b" : { "x" : 254, "y" : 347 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 248, "y" : 341 } } }, "endShape" : { "a" : { "x" : 266, "y" : 341 }, "b" : { "x" : 272, "y" : 336 }, "c" : { "x" : 264, "y" : 334 }, "type" : "ARROW", "centre" : { "x" : 264, "y" : 334 } } } ] }, { "id" : 99117, "reactomeId" : 5621138, "displayName" : "TDM", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 690, "y" : 1432 }, "minX" : 668, "maxX" : 713, "minY" : 1416, "maxY" : 1475, "prop" : { "x" : 668, "y" : 1417, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 673, "y" : 1421 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 707, "y" : 1422 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 707, "y" : 1422 } } }, "connectors" : [ { "edgeId" : 99115, "type" : "INPUT", "segments" : [ { "from" : { "x" : 692, "y" : 1450 }, "to" : { "x" : 698, "y" : 1475 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99116, "reactomeId" : 10289655, "displayName" : "CLEC4D:FCER1G dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 601, "y" : 1429 }, "minX" : 547, "maxX" : 698, "minY" : 1405, "maxY" : 1475, "prop" : { "x" : 547, "y" : 1411, "width" : 109, "height" : 36 }, "textPosition" : { "x" : 546, "y" : 1412 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 656, "y" : 1411 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 656, "y" : 1411 } } }, "connectors" : [ { "edgeId" : 99115, "type" : "INPUT", "segments" : [ { "from" : { "x" : 638, "y" : 1450 }, "to" : { "x" : 698, "y" : 1475 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99118, "reactomeId" : 10289657, "displayName" : "CLEC4D:FCER1G dimer:TDM", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 825, "y" : 1427 }, "minX" : 771, "maxX" : 886, "minY" : 1403, "maxY" : 1445, "prop" : { "x" : 771, "y" : 1409, "width" : 109, "height" : 36 }, "textPosition" : { "x" : 770, "y" : 1410 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 880, "y" : 1409 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 880, "y" : 1409 } } }, "connectors" : [ { "edgeId" : 99115, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99121, "reactomeId" : 10253655, "displayName" : "RAF1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2499, "y" : 1372 }, "minX" : 2480, "maxX" : 2525, "minY" : 1355, "maxY" : 1443, "prop" : { "x" : 2480, "y" : 1361, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 2480, "y" : 1361 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2519, "y" : 1361 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2519, "y" : 1361 } } }, "connectors" : [ { "edgeId" : 99119, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2501, "y" : 1386 }, "to" : { "x" : 2513, "y" : 1443 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99120, "reactomeId" : 10239072, "displayName" : "p21 RAS:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2439, "y" : 1443 }, "minX" : 2395, "maxX" : 2513, "minY" : 1426, "maxY" : 1454, "prop" : { "x" : 2395, "y" : 1432, "width" : 89, "height" : 22 }, "textPosition" : { "x" : 2395, "y" : 1433 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2484, "y" : 1432 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2484, "y" : 1432 } } }, "connectors" : [ { "edgeId" : 99119, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2487, "y" : 1443 }, "to" : { "x" : 2513, "y" : 1443 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99122, "reactomeId" : 10289923, "displayName" : "p21 RAS:GTP:RAF1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2654, "y" : 1443 }, "minX" : 2592, "maxX" : 2722, "minY" : 1407, "maxY" : 1454, "prop" : { "x" : 2592, "y" : 1432, "width" : 124, "height" : 22 }, "textPosition" : { "x" : 2592, "y" : 1433 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2716, "y" : 1432 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2716, "y" : 1432 } } }, "connectors" : [ { "edgeId" : 99119, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99123, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2664, "y" : 1429 }, "to" : { "x" : 2688, "y" : 1407 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99125, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2795, "y" : 1348 }, "minX" : 2752, "maxX" : 2817, "minY" : 1332, "maxY" : 1407, "prop" : { "x" : 2775, "y" : 1333, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2779, "y" : 1337 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2811, "y" : 1338 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2811, "y" : 1338 } } }, "connectors" : [ { "edgeId" : 99123, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2784, "y" : 1366 }, "to" : { "x" : 2752, "y" : 1407 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2783, "y" : 1374 }, "b" : { "x" : 2784, "y" : 1366 }, "c" : { "x" : 2777, "y" : 1369 }, "type" : "ARROW", "centre" : { "x" : 2777, "y" : 1369 } } } ] }, { "id" : 99124, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2661, "y" : 1360 }, "minX" : 2641, "maxX" : 2688, "minY" : 1344, "maxY" : 1407, "prop" : { "x" : 2641, "y" : 1345, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2645, "y" : 1349 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2676, "y" : 1350 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2676, "y" : 1350 } } }, "connectors" : [ { "edgeId" : 99123, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2669, "y" : 1378 }, "to" : { "x" : 2688, "y" : 1407 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99127, "reactomeId" : 10253034, "displayName" : "PAK1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2736, "y" : 1313 }, "minX" : 2702, "maxX" : 2770, "minY" : 1303, "maxY" : 1423, "prop" : { "x" : 2702, "y" : 1303, "width" : 68, "height" : 21 }, "textPosition" : { "x" : 2704, "y" : 1303 }, "connectors" : [ { "edgeId" : 99123, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2735, "y" : 1330 }, "to" : { "x" : 2727, "y" : 1415 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2726, "y" : 1419 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2726, "y" : 1419 } } } ] }, { "id" : 99126, "reactomeId" : 10289913, "displayName" : "p21 RAS:GTP:p-S338-RAF1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2808, "y" : 1448 }, "minX" : 2752, "maxX" : 2867, "minY" : 1407, "maxY" : 1466, "prop" : { "x" : 2755, "y" : 1430, "width" : 106, "height" : 36 }, "textPosition" : { "x" : 2756, "y" : 1431 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2861, "y" : 1430 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2861, "y" : 1430 } } }, "connectors" : [ { "edgeId" : 99123, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2783, "y" : 1427 }, "to" : { "x" : 2752, "y" : 1407 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2775, "y" : 1427 }, "b" : { "x" : 2783, "y" : 1427 }, "c" : { "x" : 2779, "y" : 1420 }, "type" : "ARROW", "centre" : { "x" : 2779, "y" : 1420 } } }, { "edgeId" : 99128, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2829, "y" : 1427 }, "to" : { "x" : 2855, "y" : 1409 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99129, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2844, "y" : 1344 }, "minX" : 2824, "maxX" : 2865, "minY" : 1328, "maxY" : 1409, "prop" : { "x" : 2824, "y" : 1329, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2828, "y" : 1333 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2859, "y" : 1334 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2859, "y" : 1334 } } }, "connectors" : [ { "edgeId" : 99128, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2846, "y" : 1362 }, "to" : { "x" : 2855, "y" : 1409 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2844, "y" : 1379 }, "b" : { "x" : 2856, "y" : 1391 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2850, "y" : 1385 } } } } ] }, { "id" : 99131, "reactomeId" : 10289919, "displayName" : "p21 RAS:GTP:p-S338,Y340,Y341-RAF1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2993, "y" : 1452 }, "minX" : 2904, "maxX" : 3057, "minY" : 1409, "maxY" : 1477, "prop" : { "x" : 2935, "y" : 1427, "width" : 116, "height" : 50 }, "textPosition" : { "x" : 2936, "y" : 1428 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3051, "y" : 1427 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3051, "y" : 1427 } } }, "connectors" : [ { "edgeId" : 99128, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2941, "y" : 1424 }, "to" : { "x" : 2904, "y" : 1409 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2933, "y" : 1425 }, "b" : { "x" : 2941, "y" : 1424 }, "c" : { "x" : 2936, "y" : 1418 }, "type" : "ARROW", "centre" : { "x" : 2936, "y" : 1418 } } } ] }, { "id" : 99130, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2941, "y" : 1344 }, "minX" : 2904, "maxX" : 2963, "minY" : 1328, "maxY" : 1409, "prop" : { "x" : 2921, "y" : 1329, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2925, "y" : 1333 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2957, "y" : 1334 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2957, "y" : 1334 } } }, "connectors" : [ { "edgeId" : 99128, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2932, "y" : 1362 }, "to" : { "x" : 2904, "y" : 1409 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2912, "y" : 1379 }, "b" : { "x" : 2924, "y" : 1391 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2918, "y" : 1385 } } }, "endShape" : { "a" : { "x" : 2932, "y" : 1370 }, "b" : { "x" : 2932, "y" : 1362 }, "c" : { "x" : 2925, "y" : 1366 }, "type" : "ARROW", "centre" : { "x" : 2925, "y" : 1366 } } } ] }, { "id" : 99132, "reactomeId" : 10289667, "displayName" : "FYN, LYN", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2894, "y" : 1308 }, "minX" : 2864, "maxX" : 2925, "minY" : 1297, "maxY" : 1429, "prop" : { "x" : 2864, "y" : 1297, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 2864, "y" : 1297 }, "connectors" : [ { "edgeId" : 99128, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2892, "y" : 1325 }, "to" : { "x" : 2883, "y" : 1421 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2883, "y" : 1425 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2883, "y" : 1425 } } } ] }, { "id" : 99135, "reactomeId" : 10292018, "displayName" : "MALT1:active caspase-8", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2730, "y" : 251 }, "minX" : 2685, "maxX" : 2781, "minY" : 227, "maxY" : 305, "prop" : { "x" : 2685, "y" : 233, "width" : 90, "height" : 36 }, "textPosition" : { "x" : 2684, "y" : 234 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2775, "y" : 233 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2775, "y" : 233 } } }, "connectors" : [ { "edgeId" : 99136, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2730, "y" : 272 }, "to" : { "x" : 2730, "y" : 305 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99133, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99134, "reactomeId" : 10235135, "displayName" : "active caspase-8", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2688, "y" : 128 }, "minX" : 2631, "maxX" : 2752, "minY" : 111, "maxY" : 163, "prop" : { "x" : 2631, "y" : 117, "width" : 115, "height" : 22 }, "textPosition" : { "x" : 2631, "y" : 118 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2746, "y" : 117 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2746, "y" : 117 } } }, "connectors" : [ { "edgeId" : 99133, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2700, "y" : 142 }, "to" : { "x" : 2729, "y" : 163 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99137, "reactomeId" : 10260794, "displayName" : "PYCARD", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2805, "y" : 290 }, "minX" : 2730, "maxX" : 2839, "minY" : 273, "maxY" : 305, "prop" : { "x" : 2777, "y" : 279, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 2777, "y" : 279 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2833, "y" : 279 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2833, "y" : 279 } } }, "connectors" : [ { "edgeId" : 99136, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2774, "y" : 295 }, "to" : { "x" : 2730, "y" : 305 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99138, "reactomeId" : 10292020, "displayName" : "MALT1 oligomers:active caspase-8:ASC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2879, "y" : 348 }, "minX" : 2650, "maxX" : 2966, "minY" : 317, "maxY" : 903, "prop" : { "x" : 2823, "y" : 323, "width" : 113, "height" : 50 }, "textPosition" : { "x" : 2823, "y" : 324 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2936, "y" : 323 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2936, "y" : 323 } } }, "connectors" : [ { "edgeId" : 99136, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99139, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2899, "y" : 376 }, "to" : { "x" : 2966, "y" : 455 } }, { "from" : { "x" : 2966, "y" : 455 }, "to" : { "x" : 2966, "y" : 621 } }, { "from" : { "x" : 2966, "y" : 621 }, "to" : { "x" : 2653, "y" : 839 } }, { "from" : { "x" : 2653, "y" : 839 }, "to" : { "x" : 2654, "y" : 895 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2654, "y" : 899 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2654, "y" : 899 } } } ] }, { "id" : 99141, "reactomeId" : 10258202, "displayName" : "IL1B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2734, "y" : 952 }, "minX" : 2685, "maxX" : 2780, "minY" : 911, "maxY" : 963, "prop" : { "x" : 2694, "y" : 941, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 2717, "y" : 941 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2774, "y" : 941 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2774, "y" : 941 } } }, "connectors" : [ { "edgeId" : 99139, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2720, "y" : 938 }, "to" : { "x" : 2685, "y" : 911 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2712, "y" : 937 }, "b" : { "x" : 2720, "y" : 938 }, "c" : { "x" : 2717, "y" : 931 }, "type" : "ARROW", "centre" : { "x" : 2717, "y" : 931 } } } ] }, { "id" : 99140, "reactomeId" : 10258184, "displayName" : "IL1B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2583, "y" : 914 }, "minX" : 2543, "maxX" : 2629, "minY" : 897, "maxY" : 925, "prop" : { "x" : 2543, "y" : 903, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 2566, "y" : 903 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2623, "y" : 903 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2623, "y" : 903 } } }, "connectors" : [ { "edgeId" : 99139, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99142, "reactomeId" : 10258194, "displayName" : "IL1B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2735, "y" : 883 }, "minX" : 2685, "maxX" : 2789, "minY" : 866, "maxY" : 911, "prop" : { "x" : 2687, "y" : 872, "width" : 96, "height" : 22 }, "textPosition" : { "x" : 2718, "y" : 872 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2783, "y" : 872 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2783, "y" : 872 } } }, "connectors" : [ { "edgeId" : 99139, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2715, "y" : 897 }, "to" : { "x" : 2685, "y" : 911 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2710, "y" : 904 }, "b" : { "x" : 2715, "y" : 897 }, "c" : { "x" : 2707, "y" : 896 }, "type" : "ARROW", "centre" : { "x" : 2707, "y" : 896 } } } ] }, { "id" : 99145, "reactomeId" : 10292030, "displayName" : "phospho-RELA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1650, "y" : 1071 }, "minX" : 1603, "maxX" : 1701, "minY" : 1047, "maxY" : 1082, "prop" : { "x" : 1605, "y" : 1060, "width" : 90, "height" : 22 }, "textPosition" : { "x" : 1616, "y" : 1054 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1695, "y" : 1060 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1695, "y" : 1060 } } }, "connectors" : [ { "edgeId" : 99143, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1628, "y" : 1057 }, "to" : { "x" : 1603, "y" : 1047 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99144, "reactomeId" : 10289002, "displayName" : "RELB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1653, "y" : 1038 }, "minX" : 1603, "maxX" : 1679, "minY" : 1021, "maxY" : 1049, "prop" : { "x" : 1634, "y" : 1027, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 1634, "y" : 1027 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1673, "y" : 1027 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1673, "y" : 1027 } } }, "connectors" : [ { "edgeId" : 99143, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1631, "y" : 1041 }, "to" : { "x" : 1603, "y" : 1047 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99146, "reactomeId" : 10292032, "displayName" : "p-S276-RELA:RELB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1474, "y" : 1048 }, "minX" : 1413, "maxX" : 1541, "minY" : 1031, "maxY" : 1059, "prop" : { "x" : 1413, "y" : 1037, "width" : 122, "height" : 22 }, "textPosition" : { "x" : 1414, "y" : 1038 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1535, "y" : 1037 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1535, "y" : 1037 } } }, "connectors" : [ { "edgeId" : 99143, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99163, "reactomeId" : 5621136, "displayName" : "alpha-mannan", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 51, "y" : 1281 }, "minX" : 0, "maxX" : 103, "minY" : 1265, "maxY" : 1296, "prop" : { "x" : 0, "y" : 1266, "width" : 102, "height" : 30 }, "textPosition" : { "x" : 2, "y" : 1270 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 97, "y" : 1271 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 97, "y" : 1271 } } }, "connectors" : [ ] }, { "id" : 98979, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 457, "y" : 118 }, "minX" : 438, "maxX" : 494, "minY" : 51, "maxY" : 133, "prop" : { "x" : 438, "y" : 103, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 442, "y" : 107 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 472, "y" : 108 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 472, "y" : 108 } } }, "connectors" : [ { "edgeId" : 98978, "type" : "INPUT", "segments" : [ { "from" : { "x" : 465, "y" : 100 }, "to" : { "x" : 494, "y" : 51 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98981, "reactomeId" : 10289028, "displayName" : "1,3-beta-D-glucan:p-Y15-CLEC7A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 651, "y" : 51 }, "minX" : 550, "maxX" : 720, "minY" : 28, "maxY" : 69, "prop" : { "x" : 589, "y" : 34, "width" : 125, "height" : 35 }, "textPosition" : { "x" : 589, "y" : 34 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 714, "y" : 34 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 714, "y" : 34 } } }, "connectors" : [ { "edgeId" : 98978, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 586, "y" : 51 }, "to" : { "x" : 550, "y" : 51 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 579, "y" : 55 }, "b" : { "x" : 586, "y" : 51 }, "c" : { "x" : 579, "y" : 47 }, "type" : "ARROW", "centre" : { "x" : 579, "y" : 47 } } } ] }, { "id" : 98980, "reactomeId" : 10289023, "displayName" : "CLEC7A:1,3-beta-D-glucan", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 415, "y" : 52 }, "minX" : 364, "maxX" : 494, "minY" : 28, "maxY" : 70, "prop" : { "x" : 364, "y" : 34, "width" : 102, "height" : 36 }, "textPosition" : { "x" : 367, "y" : 35 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 466, "y" : 34 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 466, "y" : 34 } } }, "connectors" : [ { "edgeId" : 98978, "type" : "INPUT", "segments" : [ { "from" : { "x" : 469, "y" : 51 }, "to" : { "x" : 494, "y" : 51 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98983, "reactomeId" : 10240722, "displayName" : "SRC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 523, "y" : 158 }, "minX" : 500, "maxX" : 552, "minY" : 59, "maxY" : 169, "prop" : { "x" : 500, "y" : 147, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 507, "y" : 147 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 546, "y" : 147 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 546, "y" : 147 } } }, "connectors" : [ { "edgeId" : 98978, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 522, "y" : 144 }, "to" : { "x" : 522, "y" : 67 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 522, "y" : 63 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 522, "y" : 63 } } } ] }, { "id" : 98982, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 592, "y" : 130 }, "minX" : 550, "maxX" : 614, "minY" : 51, "maxY" : 145, "prop" : { "x" : 572, "y" : 115, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 576, "y" : 119 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 608, "y" : 120 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 608, "y" : 120 } } }, "connectors" : [ { "edgeId" : 98978, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 584, "y" : 112 }, "to" : { "x" : 550, "y" : 51 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 577, "y" : 108 }, "b" : { "x" : 584, "y" : 112 }, "c" : { "x" : 584, "y" : 104 }, "type" : "ARROW", "centre" : { "x" : 584, "y" : 104 } } } ] }, { "id" : 98985, "reactomeId" : 10289040, "displayName" : "phospho-PLCG2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 945, "y" : 111 }, "minX" : 898, "maxX" : 998, "minY" : 89, "maxY" : 128, "prop" : { "x" : 898, "y" : 95, "width" : 94, "height" : 33 }, "textPosition" : { "x" : 911, "y" : 94 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 992, "y" : 95 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 992, "y" : 95 } } }, "connectors" : [ { "edgeId" : 98984, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98986, "reactomeId" : 10288984, "displayName" : "phospho-PLCG2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1086, "y" : 46 }, "minX" : 449, "maxX" : 1267, "minY" : 3, "maxY" : 283, "prop" : { "x" : 1036, "y" : 28, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 1053, "y" : 28 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1137, "y" : 28 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1137, "y" : 28 } } }, "connectors" : [ { "edgeId" : 98984, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98987, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1085, "y" : 25 }, "to" : { "x" : 1085, "y" : 3 } }, { "from" : { "x" : 1085, "y" : 3 }, "to" : { "x" : 1262, "y" : 3 } }, { "from" : { "x" : 1262, "y" : 3 }, "to" : { "x" : 1263, "y" : 62 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1263, "y" : 66 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1263, "y" : 66 } } }, { "edgeId" : 99114, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1086, "y" : 67 }, "to" : { "x" : 1088, "y" : 196 } }, { "from" : { "x" : 1088, "y" : 196 }, "to" : { "x" : 449, "y" : 283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1090, "y" : 74 }, "b" : { "x" : 1086, "y" : 67 }, "c" : { "x" : 1082, "y" : 74 }, "type" : "ARROW", "centre" : { "x" : 1082, "y" : 74 } } } ] }, { "id" : 98989, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1188, "y" : 129 }, "minX" : 1166, "maxX" : 1223, "minY" : 78, "maxY" : 144, "prop" : { "x" : 1166, "y" : 114, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1171, "y" : 118 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1206, "y" : 119 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1206, "y" : 119 } } }, "connectors" : [ { "edgeId" : 98987, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1198, "y" : 111 }, "to" : { "x" : 1223, "y" : 78 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 98988, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1195, "y" : 45 }, "minX" : 1160, "maxX" : 1232, "minY" : 29, "maxY" : 78, "prop" : { "x" : 1160, "y" : 30, "width" : 71, "height" : 30 }, "textPosition" : { "x" : 1163, "y" : 34 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1226, "y" : 35 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1226, "y" : 35 } } }, "connectors" : [ { "edgeId" : 98987, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1207, "y" : 63 }, "to" : { "x" : 1223, "y" : 78 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98991, "reactomeId" : 112275, "displayName" : "DAGs", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1329, "y" : 45 }, "minX" : 1290, "maxX" : 1383, "minY" : 29, "maxY" : 78, "prop" : { "x" : 1303, "y" : 30, "width" : 52, "height" : 30 }, "textPosition" : { "x" : 1308, "y" : 34 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1350, "y" : 35 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1350, "y" : 35 } } }, "connectors" : [ { "edgeId" : 98987, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1311, "y" : 63 }, "to" : { "x" : 1290, "y" : 78 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1308, "y" : 70 }, "b" : { "x" : 1311, "y" : 63 }, "c" : { "x" : 1303, "y" : 64 }, "type" : "ARROW", "centre" : { "x" : 1303, "y" : 64 } } }, { "edgeId" : 99004, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1358, "y" : 57 }, "to" : { "x" : 1383, "y" : 70 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98990, "reactomeId" : 114520, "displayName" : "I(1,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1339, "y" : 130 }, "minX" : 1290, "maxX" : 1379, "minY" : 78, "maxY" : 145, "prop" : { "x" : 1301, "y" : 115, "width" : 77, "height" : 30 }, "textPosition" : { "x" : 1305, "y" : 119 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1373, "y" : 120 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1373, "y" : 120 } } }, "connectors" : [ { "edgeId" : 98987, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1324, "y" : 112 }, "to" : { "x" : 1290, "y" : 78 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1316, "y" : 110 }, "b" : { "x" : 1324, "y" : 112 }, "c" : { "x" : 1322, "y" : 104 }, "type" : "ARROW", "centre" : { "x" : 1322, "y" : 104 } } } ] }, { "id" : 98993, "reactomeId" : 10234116, "displayName" : "CALM1:4xCa2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 981, "y" : 317 }, "minX" : 931, "maxX" : 1038, "minY" : 300, "maxY" : 353, "prop" : { "x" : 931, "y" : 306, "width" : 101, "height" : 22 }, "textPosition" : { "x" : 931, "y" : 307 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1032, "y" : 306 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1032, "y" : 306 } } }, "connectors" : [ { "edgeId" : 98992, "type" : "INPUT", "segments" : [ { "from" : { "x" : 968, "y" : 331 }, "to" : { "x" : 939, "y" : 353 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98995, "reactomeId" : 10275120, "displayName" : "Calcineurin (CaN)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 979, "y" : 391 }, "minX" : 921, "maxX" : 1044, "minY" : 353, "maxY" : 402, "prop" : { "x" : 921, "y" : 380, "width" : 117, "height" : 22 }, "textPosition" : { "x" : 921, "y" : 381 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1038, "y" : 380 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1038, "y" : 380 } } }, "connectors" : [ { "edgeId" : 98992, "type" : "INPUT", "segments" : [ { "from" : { "x" : 967, "y" : 377 }, "to" : { "x" : 939, "y" : 353 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98994, "reactomeId" : 74016, "displayName" : "Ca2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1157, "y" : 335 }, "minX" : 939, "maxX" : 1182, "minY" : 319, "maxY" : 353, "prop" : { "x" : 1133, "y" : 320, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1136, "y" : 324 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1176, "y" : 325 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1176, "y" : 325 } } }, "connectors" : [ { "edgeId" : 98992, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1130, "y" : 342 }, "to" : { "x" : 1098, "y" : 353 } }, { "from" : { "x" : 1098, "y" : 353 }, "to" : { "x" : 939, "y" : 353 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1108, "y" : 341 }, "b" : { "x" : 1120, "y" : 353 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1114, "y" : 347 } } } } ] }, { "id" : 98996, "reactomeId" : 10275162, "displayName" : "Calcineurin:Calmodulin (CaN:CaM)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 817, "y" : 355 }, "minX" : 700, "maxX" : 878, "minY" : 324, "maxY" : 436, "prop" : { "x" : 763, "y" : 330, "width" : 109, "height" : 50 }, "textPosition" : { "x" : 777, "y" : 331 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 872, "y" : 330 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 872, "y" : 330 } } }, "connectors" : [ { "edgeId" : 98992, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98997, "type" : "INPUT", "segments" : [ { "from" : { "x" : 760, "y" : 355 }, "to" : { "x" : 734, "y" : 355 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 98997, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 816, "y" : 383 }, "to" : { "x" : 816, "y" : 436 } }, { "from" : { "x" : 816, "y" : 436 }, "to" : { "x" : 706, "y" : 435 } }, { "from" : { "x" : 706, "y" : 435 }, "to" : { "x" : 704, "y" : 371 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 704, "y" : 367 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 704, "y" : 367 } } } ] }, { "id" : 98999, "reactomeId" : 10275156, "displayName" : "p-NFATC1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 775, "y" : 294 }, "minX" : 720, "maxX" : 830, "minY" : 276, "maxY" : 355, "prop" : { "x" : 720, "y" : 276, "width" : 110, "height" : 36 }, "textPosition" : { "x" : 729, "y" : 283 }, "connectors" : [ { "edgeId" : 98997, "type" : "INPUT", "segments" : [ { "from" : { "x" : 762, "y" : 318 }, "to" : { "x" : 734, "y" : 355 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 98998, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 776, "y" : 408 }, "minX" : 734, "maxX" : 797, "minY" : 355, "maxY" : 423, "prop" : { "x" : 756, "y" : 393, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 759, "y" : 397 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 791, "y" : 398 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 791, "y" : 398 } } }, "connectors" : [ { "edgeId" : 98997, "type" : "INPUT", "segments" : [ { "from" : { "x" : 764, "y" : 390 }, "to" : { "x" : 734, "y" : 355 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 99001, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 623, "y" : 313 }, "minX" : 606, "maxX" : 669, "minY" : 299, "maxY" : 355, "prop" : { "x" : 606, "y" : 300, "width" : 34, "height" : 26 }, "textPosition" : { "x" : 613, "y" : 302 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 635, "y" : 305 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 635, "y" : 305 } } }, "connectors" : [ { "edgeId" : 98997, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 637, "y" : 329 }, "to" : { "x" : 669, "y" : 355 } } ], "stoichiometry" : { "value" : 13, "shape" : { "a" : { "x" : 647, "y" : 336 }, "b" : { "x" : 659, "y" : 348 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 653, "y" : 342 } } }, "endShape" : { "a" : { "x" : 645, "y" : 330 }, "b" : { "x" : 637, "y" : 329 }, "c" : { "x" : 640, "y" : 336 }, "type" : "ARROW", "centre" : { "x" : 640, "y" : 336 } } } ] }, { "id" : 99000, "reactomeId" : 10280620, "displayName" : "NFAT:CaN:CaM", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 636, "y" : 402 }, "minX" : 587, "maxX" : 691, "minY" : 355, "maxY" : 413, "prop" : { "x" : 587, "y" : 391, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 587, "y" : 392 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 685, "y" : 391 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 685, "y" : 391 } } }, "connectors" : [ { "edgeId" : 98997, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 643, "y" : 388 }, "to" : { "x" : 669, "y" : 355 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 644, "y" : 380 }, "b" : { "x" : 643, "y" : 388 }, "c" : { "x" : 650, "y" : 385 }, "type" : "ARROW", "centre" : { "x" : 650, "y" : 385 } } }, { "edgeId" : 99002, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99003, "reactomeId" : 10280716, "displayName" : "NFAT:CaN:CaM", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1387, "y" : 857 }, "minX" : 1333, "maxX" : 1448, "minY" : 840, "maxY" : 868, "prop" : { "x" : 1333, "y" : 846, "width" : 109, "height" : 22 }, "textPosition" : { "x" : 1338, "y" : 847 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1442, "y" : 846 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1442, "y" : 846 } } }, "connectors" : [ { "edgeId" : 99002, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99005, "reactomeId" : 10286426, "displayName" : "phospho-PRKCD", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1434, "y" : 173 }, "minX" : 1383, "maxX" : 1487, "minY" : 70, "maxY" : 191, "prop" : { "x" : 1387, "y" : 155, "width" : 94, "height" : 36 }, "textPosition" : { "x" : 1400, "y" : 155 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1481, "y" : 155 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1481, "y" : 155 } } }, "connectors" : [ { "edgeId" : 99004, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1425, "y" : 152 }, "to" : { "x" : 1383, "y" : 70 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99006, "reactomeId" : 10288980, "displayName" : "DAGs:p-T507,S645,S664-PRKCD", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1549, "y" : 45 }, "minX" : 1483, "maxX" : 1622, "minY" : 21, "maxY" : 63, "prop" : { "x" : 1483, "y" : 27, "width" : 133, "height" : 36 }, "textPosition" : { "x" : 1485, "y" : 28 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1616, "y" : 27 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1616, "y" : 27 } } }, "connectors" : [ { "edgeId" : 99004, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99007, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99008, "reactomeId" : 10288997, "displayName" : "DAGs:active p-T507,S645,S664-PRKCD", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1772, "y" : 45 }, "minX" : 1700, "maxX" : 1958, "minY" : 0, "maxY" : 71, "prop" : { "x" : 1700, "y" : 26, "width" : 144, "height" : 38 }, "textPosition" : { "x" : 1705, "y" : 29 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1844, "y" : 26 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1844, "y" : 26 } } }, "connectors" : [ { "edgeId" : 99009, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1772, "y" : 23 }, "to" : { "x" : 1772, "y" : 0 } }, { "from" : { "x" : 1772, "y" : 0 }, "to" : { "x" : 1953, "y" : 0 } }, { "from" : { "x" : 1953, "y" : 0 }, "to" : { "x" : 1954, "y" : 63 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1954, "y" : 67 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1954, "y" : 67 } } }, { "edgeId" : 99007, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99011, "reactomeId" : 10288995, "displayName" : "CARD9", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1881, "y" : 45 }, "minX" : 1856, "maxX" : 1920, "minY" : 28, "maxY" : 79, "prop" : { "x" : 1856, "y" : 34, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 1857, "y" : 34 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1907, "y" : 34 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1907, "y" : 34 } } }, "connectors" : [ { "edgeId" : 99009, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1893, "y" : 59 }, "to" : { "x" : 1920, "y" : 79 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99010, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1884, "y" : 122 }, "minX" : 1863, "maxX" : 1920, "minY" : 79, "maxY" : 137, "prop" : { "x" : 1863, "y" : 107, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1868, "y" : 111 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1900, "y" : 112 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1900, "y" : 112 } } }, "connectors" : [ { "edgeId" : 99009, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1896, "y" : 104 }, "to" : { "x" : 1920, "y" : 79 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99013, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2028, "y" : 125 }, "minX" : 1987, "maxX" : 2050, "minY" : 79, "maxY" : 140, "prop" : { "x" : 2007, "y" : 110, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 2011, "y" : 114 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2044, "y" : 115 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2044, "y" : 115 } } }, "connectors" : [ { "edgeId" : 99009, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2014, "y" : 107 }, "to" : { "x" : 1987, "y" : 79 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2006, "y" : 105 }, "b" : { "x" : 2014, "y" : 107 }, "c" : { "x" : 2012, "y" : 99 }, "type" : "ARROW", "centre" : { "x" : 2012, "y" : 99 } } } ] }, { "id" : 99012, "reactomeId" : 10288951, "displayName" : "phospho-CARD9", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2028, "y" : 45 }, "minX" : 1974, "maxX" : 2116, "minY" : 27, "maxY" : 79, "prop" : { "x" : 1974, "y" : 33, "width" : 108, "height" : 25 }, "textPosition" : { "x" : 1974, "y" : 35 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2082, "y" : 33 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2082, "y" : 33 } } }, "connectors" : [ { "edgeId" : 99009, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2012, "y" : 61 }, "to" : { "x" : 1987, "y" : 79 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2009, "y" : 68 }, "b" : { "x" : 2012, "y" : 61 }, "c" : { "x" : 2004, "y" : 62 }, "type" : "ARROW", "centre" : { "x" : 2004, "y" : 62 } } }, { "edgeId" : 99014, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2085, "y" : 45 }, "to" : { "x" : 2116, "y" : 45 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99015, "reactomeId" : 10289036, "displayName" : "CARD9", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2089, "y" : 128 }, "minX" : 2064, "maxX" : 2121, "minY" : 45, "maxY" : 139, "prop" : { "x" : 2064, "y" : 117, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 2065, "y" : 117 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2115, "y" : 117 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2115, "y" : 117 } } }, "connectors" : [ { "edgeId" : 99014, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2092, "y" : 114 }, "to" : { "x" : 2116, "y" : 45 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2098, "y" : 73 }, "b" : { "x" : 2110, "y" : 85 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2104, "y" : 79 } } } } ] }, { "id" : 99016, "reactomeId" : 10288953, "displayName" : "p-T231-CARD9 oligomer", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 2235, "y" : 45 }, "minX" : 2177, "maxX" : 2319, "minY" : 29, "maxY" : 62, "prop" : { "x" : 2177, "y" : 29, "width" : 116, "height" : 33 }, "textPosition" : { "x" : 2185, "y" : 28 }, "connectors" : [ { "edgeId" : 99014, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99017, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2296, "y" : 45 }, "to" : { "x" : 2319, "y" : 45 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99019, "reactomeId" : 10288976, "displayName" : "p-T231-CARD9 oligomer:BCL10", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2433, "y" : 45 }, "minX" : 2375, "maxX" : 2498, "minY" : 21, "maxY" : 96, "prop" : { "x" : 2375, "y" : 27, "width" : 117, "height" : 36 }, "textPosition" : { "x" : 2381, "y" : 28 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2492, "y" : 27 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2492, "y" : 27 } } }, "connectors" : [ { "edgeId" : 99017, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99020, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2416, "y" : 66 }, "to" : { "x" : 2385, "y" : 96 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99018, "reactomeId" : 10245360, "displayName" : "BCL10", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2299, "y" : 96 }, "minX" : 2274, "maxX" : 2385, "minY" : 45, "maxY" : 107, "prop" : { "x" : 2274, "y" : 85, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 2276, "y" : 85 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2325, "y" : 85 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2325, "y" : 85 } } }, "connectors" : [ { "edgeId" : 99017, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2303, "y" : 82 }, "to" : { "x" : 2319, "y" : 45 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99020, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2328, "y" : 96 }, "to" : { "x" : 2385, "y" : 96 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2350, "y" : 90 }, "b" : { "x" : 2362, "y" : 102 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2356, "y" : 96 } } } } ] }, { "id" : 99021, "reactomeId" : 10288955, "displayName" : "p-T231-CARD9:BCL10 oligomers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2595, "y" : 44 }, "minX" : 2538, "maxX" : 2675, "minY" : 20, "maxY" : 62, "prop" : { "x" : 2538, "y" : 26, "width" : 114, "height" : 36 }, "textPosition" : { "x" : 2539, "y" : 27 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2652, "y" : 26 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2652, "y" : 26 } } }, "connectors" : [ { "edgeId" : 99020, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99022, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2655, "y" : 43 }, "to" : { "x" : 2675, "y" : 43 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99023, "reactomeId" : 10245344, "displayName" : "MALT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2775, "y" : 129 }, "minX" : 2675, "maxX" : 2871, "minY" : 43, "maxY" : 163, "prop" : { "x" : 2750, "y" : 118, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 2752, "y" : 118 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2801, "y" : 118 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2801, "y" : 118 } } }, "connectors" : [ { "edgeId" : 99022, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2751, "y" : 115 }, "to" : { "x" : 2685, "y" : 86 } }, { "from" : { "x" : 2685, "y" : 86 }, "to" : { "x" : 2675, "y" : 43 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99025, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2798, "y" : 115 }, "to" : { "x" : 2857, "y" : 91 } }, { "from" : { "x" : 2857, "y" : 91 }, "to" : { "x" : 2871, "y" : 44 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2821, "y" : 97 }, "b" : { "x" : 2833, "y" : 109 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2827, "y" : 103 } } } }, { "edgeId" : 99133, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2760, "y" : 143 }, "to" : { "x" : 2729, "y" : 163 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99024, "reactomeId" : 10288989, "displayName" : "p-T231-CARD9:BCL10 oligomers:MALT1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2784, "y" : 44 }, "minX" : 2727, "maxX" : 2871, "minY" : 14, "maxY" : 69, "prop" : { "x" : 2727, "y" : 20, "width" : 114, "height" : 49 }, "textPosition" : { "x" : 2728, "y" : 20 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2841, "y" : 20 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2841, "y" : 20 } } }, "connectors" : [ { "edgeId" : 99022, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99025, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2844, "y" : 44 }, "to" : { "x" : 2871, "y" : 44 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99026, "reactomeId" : 10288957, "displayName" : "p-T231-CARD9:BCL10:MALT1 oligomers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2989, "y" : 45 }, "minX" : 2930, "maxX" : 3077, "minY" : 14, "maxY" : 70, "prop" : { "x" : 2930, "y" : 20, "width" : 119, "height" : 50 }, "textPosition" : { "x" : 2939, "y" : 21 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3049, "y" : 20 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3049, "y" : 20 } } }, "connectors" : [ { "edgeId" : 99025, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99027, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3052, "y" : 44 }, "to" : { "x" : 3077, "y" : 44 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99029, "reactomeId" : 10289015, "displayName" : "p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3205, "y" : 45 }, "minX" : 3139, "maxX" : 3308, "minY" : 14, "maxY" : 71, "prop" : { "x" : 3139, "y" : 20, "width" : 133, "height" : 51 }, "textPosition" : { "x" : 3150, "y" : 22 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3272, "y" : 20 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3272, "y" : 20 } } }, "connectors" : [ { "edgeId" : 99027, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99030, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3275, "y" : 44 }, "to" : { "x" : 3308, "y" : 44 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99028, "reactomeId" : 10238140, "displayName" : "TRAF6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3201, "y" : 119 }, "minX" : 3077, "maxX" : 3308, "minY" : 44, "maxY" : 131, "prop" : { "x" : 3175, "y" : 108, "width" : 53, "height" : 23 }, "textPosition" : { "x" : 3178, "y" : 109 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3228, "y" : 108 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3228, "y" : 108 } } }, "connectors" : [ { "edgeId" : 99027, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3172, "y" : 110 }, "to" : { "x" : 3102, "y" : 89 } }, { "from" : { "x" : 3102, "y" : 89 }, "to" : { "x" : 3077, "y" : 44 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99030, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3231, "y" : 110 }, "to" : { "x" : 3274, "y" : 95 } }, { "from" : { "x" : 3274, "y" : 95 }, "to" : { "x" : 3308, "y" : 44 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3246, "y" : 96 }, "b" : { "x" : 3258, "y" : 108 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3252, "y" : 102 } } } } ] }, { "id" : 99031, "reactomeId" : 10289032, "displayName" : "p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3723, "y" : 46 }, "minX" : 3665, "maxX" : 3836, "minY" : 15, "maxY" : 162, "prop" : { "x" : 3665, "y" : 21, "width" : 116, "height" : 51 }, "textPosition" : { "x" : 3667, "y" : 23 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3781, "y" : 21 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3781, "y" : 21 } } }, "connectors" : [ { "edgeId" : 99030, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99032, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3750, "y" : 75 }, "to" : { "x" : 3801, "y" : 119 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99032, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3784, "y" : 46 }, "to" : { "x" : 3836, "y" : 46 } }, { "from" : { "x" : 3836, "y" : 46 }, "to" : { "x" : 3835, "y" : 157 } }, { "from" : { "x" : 3835, "y" : 157 }, "to" : { "x" : 3817, "y" : 158 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3813, "y" : 158 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3813, "y" : 158 } } } ] }, { "id" : 99033, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3629, "y" : 106 }, "minX" : 3608, "maxX" : 3801, "minY" : 91, "maxY" : 121, "prop" : { "x" : 3608, "y" : 92, "width" : 42, "height" : 29 }, "textPosition" : { "x" : 3613, "y" : 96 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3645, "y" : 97 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3645, "y" : 97 } } }, "connectors" : [ { "edgeId" : 99032, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3653, "y" : 107 }, "to" : { "x" : 3801, "y" : 119 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99035, "reactomeId" : 10238454, "displayName" : "K63polyUb", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 3590, "y" : 142 }, "minX" : 3552, "maxX" : 3801, "minY" : 119, "maxY" : 154, "prop" : { "x" : 3552, "y" : 131, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 3554, "y" : 132 }, "connectors" : [ { "edgeId" : 99032, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3632, "y" : 137 }, "to" : { "x" : 3801, "y" : 119 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99034, "reactomeId" : 10238488, "displayName" : "UBE2N:UBE2V1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3623, "y" : 186 }, "minX" : 3573, "maxX" : 3801, "minY" : 119, "maxY" : 197, "prop" : { "x" : 3573, "y" : 176, "width" : 101, "height" : 21 }, "textPosition" : { "x" : 3595, "y" : 162 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3674, "y" : 176 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3674, "y" : 176 } } }, "connectors" : [ { "edgeId" : 99032, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3650, "y" : 173 }, "to" : { "x" : 3801, "y" : 119 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99032, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3677, "y" : 189 }, "to" : { "x" : 3801, "y" : 197 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3684, "y" : 185 }, "b" : { "x" : 3677, "y" : 189 }, "c" : { "x" : 3684, "y" : 193 }, "type" : "ARROW", "centre" : { "x" : 3684, "y" : 193 } } } ] }, { "id" : 99037, "reactomeId" : 76577, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3685, "y" : 218 }, "minX" : 3663, "maxX" : 3801, "minY" : 197, "maxY" : 232, "prop" : { "x" : 3663, "y" : 205, "width" : 44, "height" : 27 }, "textPosition" : { "x" : 3668, "y" : 208 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3702, "y" : 210 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3702, "y" : 210 } } }, "connectors" : [ { "edgeId" : 99032, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3710, "y" : 214 }, "to" : { "x" : 3801, "y" : 197 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3716, "y" : 209 }, "b" : { "x" : 3710, "y" : 214 }, "c" : { "x" : 3718, "y" : 217 }, "type" : "ARROW", "centre" : { "x" : 3718, "y" : 217 } } } ] }, { "id" : 99036, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3683, "y" : 250 }, "minX" : 3666, "maxX" : 3801, "minY" : 197, "maxY" : 263, "prop" : { "x" : 3666, "y" : 237, "width" : 34, "height" : 26 }, "textPosition" : { "x" : 3669, "y" : 239 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3695, "y" : 242 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3695, "y" : 242 } } }, "connectors" : [ { "edgeId" : 99032, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3703, "y" : 242 }, "to" : { "x" : 3801, "y" : 197 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3708, "y" : 235 }, "b" : { "x" : 3703, "y" : 242 }, "c" : { "x" : 3711, "y" : 243 }, "type" : "ARROW", "centre" : { "x" : 3711, "y" : 243 } } } ] }, { "id" : 99038, "reactomeId" : 10288961, "displayName" : "p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3803, "y" : 275 }, "minX" : 3745, "maxX" : 3867, "minY" : 197, "maxY" : 344, "prop" : { "x" : 3745, "y" : 243, "width" : 116, "height" : 65 }, "textPosition" : { "x" : 3744, "y" : 245 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3861, "y" : 243 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3861, "y" : 243 } } }, "connectors" : [ { "edgeId" : 99032, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3802, "y" : 240 }, "to" : { "x" : 3801, "y" : 197 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3798, "y" : 233 }, "b" : { "x" : 3802, "y" : 240 }, "c" : { "x" : 3806, "y" : 233 }, "type" : "ARROW", "centre" : { "x" : 3806, "y" : 233 } } }, { "edgeId" : 99039, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3803, "y" : 311 }, "to" : { "x" : 3803, "y" : 344 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99041, "reactomeId" : 10289047, "displayName" : "p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3803, "y" : 454 }, "minX" : 3742, "maxX" : 3896, "minY" : 415, "maxY" : 558, "prop" : { "x" : 3742, "y" : 421, "width" : 122, "height" : 66 }, "textPosition" : { "x" : 3743, "y" : 424 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3864, "y" : 421 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3864, "y" : 421 } } }, "connectors" : [ { "edgeId" : 99039, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99042, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3803, "y" : 490 }, "to" : { "x" : 3803, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99042, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3867, "y" : 452 }, "to" : { "x" : 3896, "y" : 452 } }, { "from" : { "x" : 3896, "y" : 452 }, "to" : { "x" : 3896, "y" : 553 } }, { "from" : { "x" : 3896, "y" : 553 }, "to" : { "x" : 3819, "y" : 554 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3815, "y" : 554 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3815, "y" : 554 } } } ] }, { "id" : 99040, "reactomeId" : 10257953, "displayName" : "TAK1 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3670, "y" : 330 }, "minX" : 3628, "maxX" : 3803, "minY" : 307, "maxY" : 348, "prop" : { "x" : 3628, "y" : 313, "width" : 85, "height" : 35 }, "textPosition" : { "x" : 3641, "y" : 313 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3713, "y" : 313 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3713, "y" : 313 } } }, "connectors" : [ { "edgeId" : 99039, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3716, "y" : 334 }, "to" : { "x" : 3803, "y" : 344 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99043, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3661, "y" : 458 }, "minX" : 3638, "maxX" : 3803, "minY" : 442, "maxY" : 515, "prop" : { "x" : 3638, "y" : 443, "width" : 47, "height" : 30 }, "textPosition" : { "x" : 3646, "y" : 447 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3680, "y" : 448 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3680, "y" : 448 } } }, "connectors" : [ { "edgeId" : 99042, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3688, "y" : 467 }, "to" : { "x" : 3803, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99045, "reactomeId" : 10238488, "displayName" : "UBE2N:UBE2V1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3694, "y" : 535 }, "minX" : 3644, "maxX" : 3803, "minY" : 515, "maxY" : 581, "prop" : { "x" : 3644, "y" : 525, "width" : 101, "height" : 21 }, "textPosition" : { "x" : 3666, "y" : 511 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3745, "y" : 525 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3745, "y" : 525 } } }, "connectors" : [ { "edgeId" : 99042, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3748, "y" : 525 }, "to" : { "x" : 3803, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99042, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3718, "y" : 549 }, "to" : { "x" : 3803, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3726, "y" : 548 }, "b" : { "x" : 3718, "y" : 549 }, "c" : { "x" : 3723, "y" : 555 }, "type" : "ARROW", "centre" : { "x" : 3723, "y" : 555 } } } ] }, { "id" : 99044, "reactomeId" : 10238454, "displayName" : "K63polyUb", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 3663, "y" : 503 }, "minX" : 3625, "maxX" : 3803, "minY" : 492, "maxY" : 515, "prop" : { "x" : 3625, "y" : 492, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 3627, "y" : 493 }, "connectors" : [ { "edgeId" : 99042, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3705, "y" : 506 }, "to" : { "x" : 3803, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99047, "reactomeId" : 76577, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3633, "y" : 624 }, "minX" : 3611, "maxX" : 3803, "minY" : 581, "maxY" : 638, "prop" : { "x" : 3611, "y" : 611, "width" : 44, "height" : 27 }, "textPosition" : { "x" : 3616, "y" : 614 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3650, "y" : 616 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3650, "y" : 616 } } }, "connectors" : [ { "edgeId" : 99042, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3658, "y" : 618 }, "to" : { "x" : 3803, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3664, "y" : 612 }, "b" : { "x" : 3658, "y" : 618 }, "c" : { "x" : 3666, "y" : 620 }, "type" : "ARROW", "centre" : { "x" : 3666, "y" : 620 } } } ] }, { "id" : 99046, "reactomeId" : 10288963, "displayName" : "p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3803, "y" : 655 }, "minX" : 3712, "maxX" : 3937, "minY" : 581, "maxY" : 756, "prop" : { "x" : 3712, "y" : 623, "width" : 183, "height" : 64 }, "textPosition" : { "x" : 3714, "y" : 624 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3895, "y" : 623 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3895, "y" : 623 } } }, "connectors" : [ { "edgeId" : 99042, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3803, "y" : 620 }, "to" : { "x" : 3803, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3799, "y" : 613 }, "b" : { "x" : 3803, "y" : 620 }, "c" : { "x" : 3807, "y" : 613 }, "type" : "ARROW", "centre" : { "x" : 3807, "y" : 613 } } }, { "edgeId" : 99049, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3803, "y" : 690 }, "to" : { "x" : 3803, "y" : 719 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99049, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3898, "y" : 653 }, "to" : { "x" : 3937, "y" : 653 } }, { "from" : { "x" : 3937, "y" : 653 }, "to" : { "x" : 3937, "y" : 752 } }, { "from" : { "x" : 3937, "y" : 752 }, "to" : { "x" : 3819, "y" : 752 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3815, "y" : 752 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3815, "y" : 752 } } } ] }, { "id" : 99048, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3679, "y" : 584 }, "minX" : 3662, "maxX" : 3803, "minY" : 570, "maxY" : 597, "prop" : { "x" : 3662, "y" : 571, "width" : 34, "height" : 26 }, "textPosition" : { "x" : 3665, "y" : 573 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3691, "y" : 576 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3691, "y" : 576 } } }, "connectors" : [ { "edgeId" : 99042, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3699, "y" : 583 }, "to" : { "x" : 3803, "y" : 581 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3706, "y" : 579 }, "b" : { "x" : 3699, "y" : 583 }, "c" : { "x" : 3706, "y" : 587 }, "type" : "ARROW", "centre" : { "x" : 3706, "y" : 587 } } } ] }, { "id" : 99051, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3669, "y" : 793 }, "minX" : 3646, "maxX" : 3803, "minY" : 777, "maxY" : 808, "prop" : { "x" : 3646, "y" : 778, "width" : 47, "height" : 30 }, "textPosition" : { "x" : 3653, "y" : 782 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3688, "y" : 783 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3688, "y" : 783 } } }, "connectors" : [ { "edgeId" : 99049, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3696, "y" : 791 }, "to" : { "x" : 3803, "y" : 785 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 3743, "y" : 782 }, "b" : { "x" : 3755, "y" : 794 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3749, "y" : 788 } } }, "endShape" : { "a" : { "x" : 3703, "y" : 787 }, "b" : { "x" : 3696, "y" : 791 }, "c" : { "x" : 3703, "y" : 795 }, "type" : "ARROW", "centre" : { "x" : 3703, "y" : 795 } } } ] }, { "id" : 99050, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3677, "y" : 699 }, "minX" : 3654, "maxX" : 3803, "minY" : 683, "maxY" : 719, "prop" : { "x" : 3654, "y" : 684, "width" : 47, "height" : 30 }, "textPosition" : { "x" : 3662, "y" : 688 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3696, "y" : 689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3696, "y" : 689 } } }, "connectors" : [ { "edgeId" : 99049, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3704, "y" : 702 }, "to" : { "x" : 3803, "y" : 719 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 3747, "y" : 704 }, "b" : { "x" : 3759, "y" : 716 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3753, "y" : 710 } } } } ] }, { "id" : 99052, "reactomeId" : 10288971, "displayName" : "p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3803, "y" : 846 }, "minX" : 3393, "maxX" : 3910, "minY" : 423, "maxY" : 880, "prop" : { "x" : 3703, "y" : 813, "width" : 201, "height" : 67 }, "textPosition" : { "x" : 3711, "y" : 817 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3904, "y" : 813 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3904, "y" : 813 } } }, "connectors" : [ { "edgeId" : 99049, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3803, "y" : 810 }, "to" : { "x" : 3803, "y" : 785 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3799, "y" : 803 }, "b" : { "x" : 3803, "y" : 810 }, "c" : { "x" : 3807, "y" : 803 }, "type" : "ARROW", "centre" : { "x" : 3807, "y" : 803 } } }, { "edgeId" : 99053, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3700, "y" : 846 }, "to" : { "x" : 3627, "y" : 846 } }, { "from" : { "x" : 3627, "y" : 846 }, "to" : { "x" : 3396, "y" : 536 } }, { "from" : { "x" : 3396, "y" : 536 }, "to" : { "x" : 3397, "y" : 431 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3397, "y" : 427 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3397, "y" : 427 } } } ] }, { "id" : 99055, "reactomeId" : 10245377, "displayName" : "CHUK:IKBKB:IKBKG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3505, "y" : 416 }, "minX" : 3424, "maxX" : 3570, "minY" : 399, "maxY" : 427, "prop" : { "x" : 3446, "y" : 405, "width" : 118, "height" : 22 }, "textPosition" : { "x" : 3447, "y" : 406 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3564, "y" : 405 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3564, "y" : 405 } } }, "connectors" : [ { "edgeId" : 99053, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3443, "y" : 415 }, "to" : { "x" : 3424, "y" : 415 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99054, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3453, "y" : 348 }, "minX" : 3424, "maxX" : 3478, "minY" : 332, "maxY" : 415, "prop" : { "x" : 3430, "y" : 333, "width" : 47, "height" : 30 }, "textPosition" : { "x" : 3438, "y" : 337 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3472, "y" : 338 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3472, "y" : 338 } } }, "connectors" : [ { "edgeId" : 99053, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3446, "y" : 366 }, "to" : { "x" : 3424, "y" : 415 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3429, "y" : 384 }, "b" : { "x" : 3441, "y" : 396 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3435, "y" : 390 } } } } ] }, { "id" : 99057, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3341, "y" : 344 }, "minX" : 3318, "maxX" : 3373, "minY" : 328, "maxY" : 415, "prop" : { "x" : 3318, "y" : 329, "width" : 47, "height" : 30 }, "textPosition" : { "x" : 3325, "y" : 333 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3360, "y" : 334 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3360, "y" : 334 } } }, "connectors" : [ { "edgeId" : 99053, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3347, "y" : 362 }, "to" : { "x" : 3373, "y" : 415 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 3354, "y" : 382 }, "b" : { "x" : 3366, "y" : 394 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3360, "y" : 388 } } }, "endShape" : { "a" : { "x" : 3354, "y" : 366 }, "b" : { "x" : 3347, "y" : 362 }, "c" : { "x" : 3346, "y" : 370 }, "type" : "ARROW", "centre" : { "x" : 3346, "y" : 370 } } } ] }, { "id" : 99056, "reactomeId" : 10245379, "displayName" : "CHUK:p-S177,S181-IKBKB:IKBKG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3290, "y" : 416 }, "minX" : 3209, "maxX" : 3373, "minY" : 393, "maxY" : 433, "prop" : { "x" : 3236, "y" : 399, "width" : 109, "height" : 34 }, "textPosition" : { "x" : 3244, "y" : 384 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3345, "y" : 399 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3345, "y" : 399 } } }, "connectors" : [ { "edgeId" : 99087, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3233, "y" : 415 }, "to" : { "x" : 3209, "y" : 415 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99053, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3348, "y" : 415 }, "to" : { "x" : 3373, "y" : 415 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3355, "y" : 411 }, "b" : { "x" : 3348, "y" : 415 }, "c" : { "x" : 3355, "y" : 419 }, "type" : "ARROW", "centre" : { "x" : 3355, "y" : 419 } } } ] }, { "id" : 99059, "reactomeId" : 10253633, "displayName" : "MAP3K14", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1840, "y" : 672 }, "minX" : 1807, "maxX" : 1880, "minY" : 656, "maxY" : 683, "prop" : { "x" : 1807, "y" : 662, "width" : 67, "height" : 21 }, "textPosition" : { "x" : 1808, "y" : 662 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1874, "y" : 662 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1874, "y" : 662 } } }, "connectors" : [ { "edgeId" : 99058, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99061, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1985, "y" : 714 }, "minX" : 1965, "maxX" : 2031, "minY" : 672, "maxY" : 729, "prop" : { "x" : 1965, "y" : 699, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1969, "y" : 703 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2000, "y" : 704 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2000, "y" : 704 } } }, "connectors" : [ { "edgeId" : 99060, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2001, "y" : 696 }, "to" : { "x" : 2031, "y" : 672 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 2010, "y" : 678 }, "b" : { "x" : 2022, "y" : 690 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2016, "y" : 684 } } } } ] }, { "id" : 99063, "reactomeId" : 10253633, "displayName" : "MAP3K14", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1967, "y" : 672 }, "minX" : 1933, "maxX" : 2062, "minY" : 633, "maxY" : 683, "prop" : { "x" : 1933, "y" : 661, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 1935, "y" : 661 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2002, "y" : 661 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2002, "y" : 661 } } }, "connectors" : [ { "edgeId" : 99060, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2005, "y" : 672 }, "to" : { "x" : 2031, "y" : 672 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99060, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1967, "y" : 658 }, "to" : { "x" : 1967, "y" : 633 } }, { "from" : { "x" : 1967, "y" : 633 }, "to" : { "x" : 2058, "y" : 633 } }, { "from" : { "x" : 2058, "y" : 633 }, "to" : { "x" : 2058, "y" : 656 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2058, "y" : 660 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2058, "y" : 660 } } } ] }, { "id" : 99062, "reactomeId" : 10288905, "displayName" : "IKKA dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2014, "y" : 756 }, "minX" : 1977, "maxX" : 2057, "minY" : 672, "maxY" : 767, "prop" : { "x" : 1977, "y" : 745, "width" : 74, "height" : 22 }, "textPosition" : { "x" : 1978, "y" : 746 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2051, "y" : 745 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2051, "y" : 745 } } }, "connectors" : [ { "edgeId" : 99060, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2016, "y" : 742 }, "to" : { "x" : 2031, "y" : 672 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99065, "reactomeId" : 10288891, "displayName" : "Active NIK:p-S176,180-IKKA dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2188, "y" : 673 }, "minX" : 2089, "maxX" : 2273, "minY" : 497, "maxY" : 691, "prop" : { "x" : 2125, "y" : 656, "width" : 126, "height" : 35 }, "textPosition" : { "x" : 2128, "y" : 656 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2251, "y" : 656 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2251, "y" : 656 } } }, "connectors" : [ { "edgeId" : 99076, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2179, "y" : 653 }, "to" : { "x" : 2128, "y" : 553 } }, { "from" : { "x" : 2128, "y" : 553 }, "to" : { "x" : 2184, "y" : 497 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2172, "y" : 649 }, "b" : { "x" : 2179, "y" : 653 }, "c" : { "x" : 2179, "y" : 645 }, "type" : "ARROW", "centre" : { "x" : 2179, "y" : 645 } } }, { "edgeId" : 99060, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2122, "y" : 672 }, "to" : { "x" : 2089, "y" : 672 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2115, "y" : 676 }, "b" : { "x" : 2122, "y" : 672 }, "c" : { "x" : 2115, "y" : 668 }, "type" : "ARROW", "centre" : { "x" : 2115, "y" : 668 } } }, { "edgeId" : 99066, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2254, "y" : 673 }, "to" : { "x" : 2273, "y" : 673 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99064, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2117, "y" : 607 }, "minX" : 2089, "maxX" : 2139, "minY" : 591, "maxY" : 672, "prop" : { "x" : 2097, "y" : 592, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2101, "y" : 596 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2133, "y" : 597 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2133, "y" : 597 } } }, "connectors" : [ { "edgeId" : 99060, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2110, "y" : 625 }, "to" : { "x" : 2089, "y" : 672 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 2093, "y" : 642 }, "b" : { "x" : 2105, "y" : 654 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2099, "y" : 648 } } }, "endShape" : { "a" : { "x" : 2111, "y" : 633 }, "b" : { "x" : 2110, "y" : 625 }, "c" : { "x" : 2104, "y" : 630 }, "type" : "ARROW", "centre" : { "x" : 2104, "y" : 630 } } } ] }, { "id" : 99067, "reactomeId" : 10288897, "displayName" : "p100:RELB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2221, "y" : 723 }, "minX" : 2184, "maxX" : 2273, "minY" : 673, "maxY" : 734, "prop" : { "x" : 2184, "y" : 712, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 2184, "y" : 713 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2259, "y" : 712 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2259, "y" : 712 } } }, "connectors" : [ { "edgeId" : 99066, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2232, "y" : 709 }, "to" : { "x" : 2273, "y" : 673 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 99068, "reactomeId" : 10288899, "displayName" : "Active NIK:p-S176,180-IKKA dimer:p100:RELB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2326, "y" : 730 }, "minX" : 2266, "maxX" : 2417, "minY" : 666, "maxY" : 755, "prop" : { "x" : 2266, "y" : 705, "width" : 120, "height" : 50 }, "textPosition" : { "x" : 2266, "y" : 706 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2386, "y" : 705 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2386, "y" : 705 } } }, "connectors" : [ { "edgeId" : 99066, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99069, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2343, "y" : 702 }, "to" : { "x" : 2371, "y" : 666 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 99069, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2389, "y" : 725 }, "to" : { "x" : 2387, "y" : 725 } }, { "from" : { "x" : 2387, "y" : 725 }, "to" : { "x" : 2412, "y" : 725 } }, { "from" : { "x" : 2412, "y" : 725 }, "to" : { "x" : 2413, "y" : 682 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2413, "y" : 678 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2413, "y" : 678 } } } ] }, { "id" : 99071, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2471, "y" : 721 }, "minX" : 2450, "maxX" : 2493, "minY" : 666, "maxY" : 736, "prop" : { "x" : 2451, "y" : 706, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2455, "y" : 710 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2487, "y" : 711 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2487, "y" : 711 } } }, "connectors" : [ { "edgeId" : 99069, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2465, "y" : 703 }, "to" : { "x" : 2450, "y" : 666 } } ], "stoichiometry" : { "value" : 7, "shape" : { "a" : { "x" : 2451, "y" : 678 }, "b" : { "x" : 2463, "y" : 690 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2457, "y" : 684 } } }, "endShape" : { "a" : { "x" : 2459, "y" : 698 }, "b" : { "x" : 2465, "y" : 703 }, "c" : { "x" : 2466, "y" : 695 }, "type" : "ARROW", "centre" : { "x" : 2466, "y" : 695 } } } ] }, { "id" : 99070, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2315, "y" : 629 }, "minX" : 2295, "maxX" : 2371, "minY" : 613, "maxY" : 666, "prop" : { "x" : 2295, "y" : 614, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2299, "y" : 618 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2330, "y" : 619 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2330, "y" : 619 } } }, "connectors" : [ { "edgeId" : 99069, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2338, "y" : 642 }, "to" : { "x" : 2371, "y" : 666 } } ], "stoichiometry" : { "value" : 7, "shape" : { "a" : { "x" : 2348, "y" : 648 }, "b" : { "x" : 2360, "y" : 660 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2354, "y" : 654 } } } } ] } ], "edges" : [ { "id" : 99073, "reactomeId" : 10288925, "displayName" : "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2512, "y" : 499 }, "minX" : 2474, "maxX" : 2555, "minY" : 493, "maxY" : 505, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2555, "y" : 499 }, "to" : { "x" : 2512, "y" : 499 } }, { "from" : { "x" : 2512, "y" : 499 }, "to" : { "x" : 2474, "y" : 499 } } ], "endShape" : { "a" : { "x" : 2481, "y" : 495 }, "b" : { "x" : 2474, "y" : 499 }, "c" : { "x" : 2481, "y" : 503 }, "type" : "ARROW", "centre" : { "x" : 2481, "y" : 503 } }, "reactionShape" : { "c" : { "x" : 2512, "y" : 499 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2512, "y" : 499 } }, "inputs" : [ { "id" : 99074, "points" : [ { "x" : 2565, "y" : 490 } ] }, { "id" : 99072, "points" : [ { "x" : 2564, "y" : 509 } ] } ], "outputs" : [ { "id" : 99075 } ] }, { "id" : 99009, "reactomeId" : 10289000, "displayName" : "PKC-delta phosphorylates CARD9", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1954, "y" : 79 }, "minX" : 1920, "maxX" : 1987, "minY" : 73, "maxY" : 85, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1920, "y" : 79 }, "to" : { "x" : 1954, "y" : 79 } }, { "from" : { "x" : 1954, "y" : 79 }, "to" : { "x" : 1987, "y" : 79 } } ], "reactionShape" : { "a" : { "x" : 1948, "y" : 73 }, "b" : { "x" : 1960, "y" : 85 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1954, "y" : 79 } }, "inputs" : [ { "id" : 99010, "points" : [ { "x" : 1896, "y" : 104 } ] }, { "id" : 99011, "points" : [ { "x" : 1893, "y" : 59 } ] } ], "outputs" : [ { "id" : 99012, "points" : [ { "x" : 2012, "y" : 61 } ] }, { "id" : 99013, "points" : [ { "x" : 2014, "y" : 107 } ] } ], "catalysts" : [ { "id" : 99008, "points" : [ { "x" : 1772, "y" : 23 }, { "x" : 1772, "y" : 0 }, { "x" : 1953, "y" : 0 } ] } ] }, { "id" : 99136, "reactomeId" : 10292022, "displayName" : "ASC binds Caspase-8 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2730, "y" : 347 }, "minX" : 2724, "maxX" : 2820, "minY" : 305, "maxY" : 353, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2730, "y" : 305 }, "to" : { "x" : 2730, "y" : 347 } }, { "from" : { "x" : 2730, "y" : 347 }, "to" : { "x" : 2820, "y" : 347 } } ], "endShape" : { "a" : { "x" : 2813, "y" : 351 }, "b" : { "x" : 2820, "y" : 347 }, "c" : { "x" : 2813, "y" : 343 }, "type" : "ARROW", "centre" : { "x" : 2813, "y" : 343 } }, "reactionShape" : { "c" : { "x" : 2730, "y" : 347 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2730, "y" : 347 } }, "inputs" : [ { "id" : 99137, "points" : [ { "x" : 2774, "y" : 295 } ] }, { "id" : 99135, "points" : [ { "x" : 2730, "y" : 272 } ] } ], "outputs" : [ { "id" : 99138 } ] }, { "id" : 99139, "reactomeId" : 10292025, "displayName" : "Caspase-8 cleaves IL1B precursor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2654, "y" : 911 }, "minX" : 2626, "maxX" : 2685, "minY" : 905, "maxY" : 917, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2626, "y" : 912 }, "to" : { "x" : 2654, "y" : 911 } }, { "from" : { "x" : 2654, "y" : 911 }, "to" : { "x" : 2685, "y" : 911 } } ], "reactionShape" : { "a" : { "x" : 2648, "y" : 905 }, "b" : { "x" : 2660, "y" : 917 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2654, "y" : 911 } }, "inputs" : [ { "id" : 99140 } ], "outputs" : [ { "id" : 99141, "points" : [ { "x" : 2720, "y" : 938 } ] }, { "id" : 99142, "points" : [ { "x" : 2715, "y" : 897 } ] } ], "catalysts" : [ { "id" : 99138, "points" : [ { "x" : 2899, "y" : 376 }, { "x" : 2966, "y" : 455 }, { "x" : 2966, "y" : 621 }, { "x" : 2653, "y" : 839 } ] } ] }, { "id" : 99076, "reactomeId" : 10288933, "displayName" : "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2225, "y" : 497 }, "minX" : 2184, "maxX" : 2298, "minY" : 491, "maxY" : 503, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2298, "y" : 497 }, "to" : { "x" : 2225, "y" : 497 } }, { "from" : { "x" : 2225, "y" : 497 }, "to" : { "x" : 2184, "y" : 497 } } ], "reactionShape" : { "a" : { "x" : 2219, "y" : 491 }, "b" : { "x" : 2231, "y" : 503 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2225, "y" : 497 } }, "inputs" : [ { "id" : 99077, "points" : [ { "x" : 2286, "y" : 574 }, { "x" : 2303, "y" : 574 } ] }, { "id" : 99078, "points" : [ { "x" : 2249, "y" : 452 } ] }, { "id" : 99075, "points" : [ { "x" : 2338, "y" : 497 } ] }, { "id" : 99079, "points" : [ { "x" : 2347, "y" : 457 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 99074, "points" : [ { "x" : 2565, "y" : 462 }, { "x" : 2510, "y" : 404 }, { "x" : 2203, "y" : 404 } ] }, { "id" : 99065, "points" : [ { "x" : 2179, "y" : 653 }, { "x" : 2128, "y" : 553 } ] }, { "id" : 99077, "points" : [ { "x" : 2210, "y" : 553 } ] }, { "id" : 99078, "points" : [ { "x" : 2227, "y" : 452 } ] }, { "id" : 99080, "points" : [ { "x" : 2141, "y" : 497 } ] } ], "catalysts" : [ { "id" : 99075, "points" : [ { "x" : 2338, "y" : 520 }, { "x" : 2312, "y" : 530 }, { "x" : 2224, "y" : 530 } ] } ] }, { "id" : 99143, "reactomeId" : 10292034, "displayName" : "p-S276-RELA binds RELB", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1571, "y" : 1047 }, "minX" : 1538, "maxX" : 1603, "minY" : 1041, "maxY" : 1053, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1603, "y" : 1047 }, "to" : { "x" : 1571, "y" : 1047 } }, { "from" : { "x" : 1571, "y" : 1047 }, "to" : { "x" : 1538, "y" : 1047 } } ], "endShape" : { "a" : { "x" : 1545, "y" : 1043 }, "b" : { "x" : 1538, "y" : 1047 }, "c" : { "x" : 1545, "y" : 1051 }, "type" : "ARROW", "centre" : { "x" : 1545, "y" : 1051 } }, "reactionShape" : { "c" : { "x" : 1571, "y" : 1047 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1571, "y" : 1047 } }, "inputs" : [ { "id" : 99144, "points" : [ { "x" : 1631, "y" : 1041 } ] }, { "id" : 99145, "points" : [ { "x" : 1628, "y" : 1057 } ] } ], "outputs" : [ { "id" : 99146 } ] }, { "id" : 99014, "reactomeId" : 10289038, "displayName" : "CARD9 oligomerizes", "schemaClass" : "Polymerisation", "renderableClass" : "Reaction", "position" : { "x" : 2143, "y" : 45 }, "minX" : 2116, "maxX" : 2174, "minY" : 39, "maxY" : 51, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2116, "y" : 45 }, "to" : { "x" : 2143, "y" : 45 } }, { "from" : { "x" : 2143, "y" : 45 }, "to" : { "x" : 2174, "y" : 45 } } ], "endShape" : { "a" : { "x" : 2167, "y" : 49 }, "b" : { "x" : 2174, "y" : 45 }, "c" : { "x" : 2167, "y" : 41 }, "type" : "ARROW", "centre" : { "x" : 2167, "y" : 41 } }, "reactionShape" : { "c" : { "x" : 2143, "y" : 45 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2143, "y" : 45 } }, "inputs" : [ { "id" : 99015, "points" : [ { "x" : 2092, "y" : 114 } ], "stoichiometry" : 2 }, { "id" : 99012, "points" : [ { "x" : 2085, "y" : 45 } ] } ], "outputs" : [ { "id" : 99016 } ] }, { "id" : 99017, "reactomeId" : 10288978, "displayName" : "BCL10 binds CARD9", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2341, "y" : 45 }, "minX" : 2319, "maxX" : 2372, "minY" : 39, "maxY" : 51, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2319, "y" : 45 }, "to" : { "x" : 2341, "y" : 45 } }, { "from" : { "x" : 2341, "y" : 45 }, "to" : { "x" : 2372, "y" : 45 } } ], "endShape" : { "a" : { "x" : 2365, "y" : 49 }, "b" : { "x" : 2372, "y" : 45 }, "c" : { "x" : 2365, "y" : 41 }, "type" : "ARROW", "centre" : { "x" : 2365, "y" : 41 } }, "reactionShape" : { "c" : { "x" : 2341, "y" : 45 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2341, "y" : 45 } }, "inputs" : [ { "id" : 99016, "points" : [ { "x" : 2296, "y" : 45 } ] }, { "id" : 99018, "points" : [ { "x" : 2303, "y" : 82 } ] } ], "outputs" : [ { "id" : 99019 } ] }, { "id" : 99081, "reactomeId" : 10288940, "displayName" : "26S proteasome processes p-7S-p100:RELB to form p52:RELB", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1972, "y" : 497 }, "minX" : 1927, "maxX" : 2012, "minY" : 491, "maxY" : 503, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2012, "y" : 497 }, "to" : { "x" : 1972, "y" : 497 } }, { "from" : { "x" : 1972, "y" : 497 }, "to" : { "x" : 1927, "y" : 497 } } ], "reactionShape" : { "a" : { "x" : 1966, "y" : 491 }, "b" : { "x" : 1978, "y" : 503 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1972, "y" : 497 } }, "inputs" : [ { "id" : 99080 } ], "outputs" : [ { "id" : 99082, "points" : [ { "x" : 1881, "y" : 470 } ], "stoichiometry" : 4 }, { "id" : 99083, "points" : [ { "x" : 1882, "y" : 535 } ] } ], "catalysts" : [ { "id" : 99084, "points" : [ { "x" : 1972, "y" : 431 } ] } ] }, { "id" : 99085, "reactomeId" : 10289006, "displayName" : "p52:RELB translocates from cytosol to nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1622, "y" : 725 }, "minX" : 1616, "maxX" : 1854, "minY" : 563, "maxY" : 837, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1854, "y" : 563 }, "to" : { "x" : 1622, "y" : 725 } }, { "from" : { "x" : 1622, "y" : 725 }, "to" : { "x" : 1643, "y" : 837 } } ], "endShape" : { "a" : { "x" : 1638, "y" : 831 }, "b" : { "x" : 1643, "y" : 837 }, "c" : { "x" : 1646, "y" : 829 }, "type" : "ARROW", "centre" : { "x" : 1646, "y" : 829 } }, "reactionShape" : { "a" : { "x" : 1616, "y" : 719 }, "b" : { "x" : 1628, "y" : 731 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1622, "y" : 725 } }, "inputs" : [ { "id" : 99083 } ], "outputs" : [ { "id" : 99086 } ] }, { "id" : 99020, "reactomeId" : 10288993, "displayName" : "BCL10 oligomerizes", "schemaClass" : "Polymerisation", "renderableClass" : "Reaction", "position" : { "x" : 2507, "y" : 44 }, "minX" : 2385, "maxX" : 2535, "minY" : 38, "maxY" : 96, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2385, "y" : 96 }, "to" : { "x" : 2485, "y" : 96 } }, { "from" : { "x" : 2485, "y" : 96 }, "to" : { "x" : 2507, "y" : 44 } }, { "from" : { "x" : 2507, "y" : 44 }, "to" : { "x" : 2535, "y" : 44 } } ], "endShape" : { "a" : { "x" : 2528, "y" : 48 }, "b" : { "x" : 2535, "y" : 44 }, "c" : { "x" : 2528, "y" : 40 }, "type" : "ARROW", "centre" : { "x" : 2528, "y" : 40 } }, "reactionShape" : { "c" : { "x" : 2507, "y" : 44 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2507, "y" : 44 } }, "inputs" : [ { "id" : 99019, "points" : [ { "x" : 2416, "y" : 66 } ] }, { "id" : 99018, "points" : [ { "x" : 2328, "y" : 96 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 99021 } ] }, { "id" : 99087, "reactomeId" : 10245415, "displayName" : "Ubiquitination of NEMO by TRAF6", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3176, "y" : 415 }, "minX" : 3133, "maxX" : 3209, "minY" : 409, "maxY" : 421, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3209, "y" : 415 }, "to" : { "x" : 3176, "y" : 415 } }, { "from" : { "x" : 3176, "y" : 415 }, "to" : { "x" : 3133, "y" : 415 } } ], "reactionShape" : { "a" : { "x" : 3170, "y" : 409 }, "b" : { "x" : 3182, "y" : 421 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3176, "y" : 415 } }, "inputs" : [ { "id" : 99056, "points" : [ { "x" : 3233, "y" : 415 } ] }, { "id" : 99088, "points" : [ { "x" : 3239, "y" : 453 } ] }, { "id" : 99089, "points" : [ { "x" : 3178, "y" : 379 } ] } ], "outputs" : [ { "id" : 99090, "points" : [ { "x" : 3090, "y" : 415 } ] }, { "id" : 99089, "points" : [ { "x" : 3162, "y" : 379 } ] } ], "catalysts" : [ { "id" : 99091, "points" : [ { "x" : 3177, "y" : 553 } ] } ] }, { "id" : 99022, "reactomeId" : 10289011, "displayName" : "MALT1 binds BCL10", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2695, "y" : 43 }, "minX" : 2675, "maxX" : 2724, "minY" : 37, "maxY" : 49, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2675, "y" : 43 }, "to" : { "x" : 2695, "y" : 43 } }, { "from" : { "x" : 2695, "y" : 43 }, "to" : { "x" : 2724, "y" : 43 } } ], "endShape" : { "a" : { "x" : 2717, "y" : 47 }, "b" : { "x" : 2724, "y" : 43 }, "c" : { "x" : 2717, "y" : 39 }, "type" : "ARROW", "centre" : { "x" : 2717, "y" : 39 } }, "reactionShape" : { "c" : { "x" : 2695, "y" : 43 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2695, "y" : 43 } }, "inputs" : [ { "id" : 99023, "points" : [ { "x" : 2751, "y" : 115 }, { "x" : 2685, "y" : 86 } ] }, { "id" : 99021, "points" : [ { "x" : 2655, "y" : 43 } ] } ], "outputs" : [ { "id" : 99024 } ] }, { "id" : 99025, "reactomeId" : 10288991, "displayName" : "MALT1 oligomerizes", "schemaClass" : "Polymerisation", "renderableClass" : "Reaction", "position" : { "x" : 2897, "y" : 44 }, "minX" : 2871, "maxX" : 2927, "minY" : 38, "maxY" : 50, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2871, "y" : 44 }, "to" : { "x" : 2897, "y" : 44 } }, { "from" : { "x" : 2897, "y" : 44 }, "to" : { "x" : 2927, "y" : 44 } } ], "endShape" : { "a" : { "x" : 2920, "y" : 48 }, "b" : { "x" : 2927, "y" : 44 }, "c" : { "x" : 2920, "y" : 40 }, "type" : "ARROW", "centre" : { "x" : 2920, "y" : 40 } }, "reactionShape" : { "c" : { "x" : 2897, "y" : 44 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2897, "y" : 44 } }, "inputs" : [ { "id" : 99023, "points" : [ { "x" : 2798, "y" : 115 }, { "x" : 2857, "y" : 91 } ], "stoichiometry" : 2 }, { "id" : 99024, "points" : [ { "x" : 2844, "y" : 44 } ] } ], "outputs" : [ { "id" : 99026 } ] }, { "id" : 99027, "reactomeId" : 10289017, "displayName" : "TRAF6 binds MALT1 oligomers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3104, "y" : 44 }, "minX" : 3077, "maxX" : 3136, "minY" : 38, "maxY" : 50, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3077, "y" : 44 }, "to" : { "x" : 3104, "y" : 44 } }, { "from" : { "x" : 3104, "y" : 44 }, "to" : { "x" : 3136, "y" : 44 } } ], "endShape" : { "a" : { "x" : 3129, "y" : 48 }, "b" : { "x" : 3136, "y" : 44 }, "c" : { "x" : 3129, "y" : 40 }, "type" : "ARROW", "centre" : { "x" : 3129, "y" : 40 } }, "reactionShape" : { "c" : { "x" : 3104, "y" : 44 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3104, "y" : 44 } }, "inputs" : [ { "id" : 99028, "points" : [ { "x" : 3172, "y" : 110 }, { "x" : 3102, "y" : 89 } ] }, { "id" : 99026, "points" : [ { "x" : 3052, "y" : 44 } ] } ], "outputs" : [ { "id" : 99029 } ] }, { "id" : 99092, "reactomeId" : 10289665, "displayName" : "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 389, "y" : 1352 }, "minX" : 363, "maxX" : 414, "minY" : 1346, "maxY" : 1358, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 414, "y" : 1352 }, "to" : { "x" : 389, "y" : 1352 } }, { "from" : { "x" : 389, "y" : 1352 }, "to" : { "x" : 363, "y" : 1352 } } ], "endShape" : { "a" : { "x" : 370, "y" : 1348 }, "b" : { "x" : 363, "y" : 1352 }, "c" : { "x" : 370, "y" : 1356 }, "type" : "ARROW", "centre" : { "x" : 370, "y" : 1356 } }, "reactionShape" : { "c" : { "x" : 389, "y" : 1352 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 389, "y" : 1352 } }, "inputs" : [ { "id" : 99093, "points" : [ { "x" : 444, "y" : 1414 } ] }, { "id" : 99094, "points" : [ { "x" : 434, "y" : 1352 } ] } ], "outputs" : [ { "id" : 99095 } ] }, { "id" : 99030, "reactomeId" : 10289034, "displayName" : "TRAF6 oligomerizes", "schemaClass" : "Polymerisation", "renderableClass" : "Reaction", "position" : { "x" : 3341, "y" : 44 }, "minX" : 3308, "maxX" : 3662, "minY" : 38, "maxY" : 50, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3308, "y" : 44 }, "to" : { "x" : 3341, "y" : 44 } }, { "from" : { "x" : 3341, "y" : 44 }, "to" : { "x" : 3662, "y" : 45 } } ], "endShape" : { "a" : { "x" : 3655, "y" : 49 }, "b" : { "x" : 3662, "y" : 45 }, "c" : { "x" : 3655, "y" : 41 }, "type" : "ARROW", "centre" : { "x" : 3655, "y" : 41 } }, "reactionShape" : { "c" : { "x" : 3341, "y" : 44 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3341, "y" : 44 } }, "inputs" : [ { "id" : 99028, "points" : [ { "x" : 3231, "y" : 110 }, { "x" : 3274, "y" : 95 } ], "stoichiometry" : 2 }, { "id" : 99029, "points" : [ { "x" : 3275, "y" : 44 } ] } ], "outputs" : [ { "id" : 99031 } ] }, { "id" : 99032, "reactomeId" : 10289045, "displayName" : "TRAF6 oligomer autoubiquitinates", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3801, "y" : 158 }, "minX" : 3795, "maxX" : 3807, "minY" : 119, "maxY" : 197, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3801, "y" : 119 }, "to" : { "x" : 3801, "y" : 158 } }, { "from" : { "x" : 3801, "y" : 158 }, "to" : { "x" : 3801, "y" : 197 } } ], "reactionShape" : { "a" : { "x" : 3795, "y" : 152 }, "b" : { "x" : 3807, "y" : 164 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3801, "y" : 158 } }, "inputs" : [ { "id" : 99033, "points" : [ { "x" : 3653, "y" : 107 } ] }, { "id" : 99031, "points" : [ { "x" : 3750, "y" : 75 } ] }, { "id" : 99034, "points" : [ { "x" : 3650, "y" : 173 } ] }, { "id" : 99035, "points" : [ { "x" : 3632, "y" : 137 } ] } ], "outputs" : [ { "id" : 99036, "points" : [ { "x" : 3703, "y" : 242 } ] }, { "id" : 99037, "points" : [ { "x" : 3710, "y" : 214 } ] }, { "id" : 99038, "points" : [ { "x" : 3802, "y" : 240 } ] }, { "id" : 99034, "points" : [ { "x" : 3677, "y" : 189 } ] } ], "catalysts" : [ { "id" : 99031, "points" : [ { "x" : 3784, "y" : 46 }, { "x" : 3836, "y" : 46 }, { "x" : 3835, "y" : 157 } ] } ] }, { "id" : 99096, "reactomeId" : 10289670, "displayName" : "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 177, "y" : 1029 }, "minX" : 171, "maxX" : 199, "minY" : 1003, "maxY" : 1065, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 199, "y" : 1065 }, "to" : { "x" : 177, "y" : 1029 } }, { "from" : { "x" : 177, "y" : 1029 }, "to" : { "x" : 199, "y" : 1003 } } ], "reactionShape" : { "a" : { "x" : 171, "y" : 1023 }, "b" : { "x" : 183, "y" : 1035 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 177, "y" : 1029 } }, "inputs" : [ { "id" : 99097, "points" : [ { "x" : 188, "y" : 1093 } ] }, { "id" : 99098, "points" : [ { "x" : 272, "y" : 1071 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 99099, "points" : [ { "x" : 272, "y" : 983 } ], "stoichiometry" : 2 }, { "id" : 99100, "points" : [ { "x" : 187, "y" : 969 } ] } ], "catalysts" : [ { "id" : 99101, "points" : [ { "x" : 233, "y" : 1028 } ] } ] }, { "id" : 99039, "reactomeId" : 10289052, "displayName" : "TRIKA2 binds K63polyUb-TRAF6 oligomer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3803, "y" : 379 }, "minX" : 3797, "maxX" : 3809, "minY" : 344, "maxY" : 418, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3803, "y" : 344 }, "to" : { "x" : 3803, "y" : 379 } }, { "from" : { "x" : 3803, "y" : 379 }, "to" : { "x" : 3803, "y" : 418 } } ], "endShape" : { "a" : { "x" : 3799, "y" : 411 }, "b" : { "x" : 3803, "y" : 418 }, "c" : { "x" : 3807, "y" : 411 }, "type" : "ARROW", "centre" : { "x" : 3807, "y" : 411 } }, "reactionShape" : { "c" : { "x" : 3803, "y" : 379 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3803, "y" : 379 } }, "inputs" : [ { "id" : 99038, "points" : [ { "x" : 3803, "y" : 311 } ] }, { "id" : 99040, "points" : [ { "x" : 3716, "y" : 334 } ] } ], "outputs" : [ { "id" : 99041 } ] }, { "id" : 99102, "reactomeId" : 10289679, "displayName" : "SYK binds to p-Y65,Y76-FCER1G", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 188, "y" : 857 }, "minX" : 182, "maxX" : 212, "minY" : 812, "maxY" : 885, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 208, "y" : 885 }, "to" : { "x" : 188, "y" : 857 } }, { "from" : { "x" : 188, "y" : 857 }, "to" : { "x" : 212, "y" : 837 } }, { "from" : { "x" : 212, "y" : 837 }, "to" : { "x" : 191, "y" : 812 } } ], "endShape" : { "a" : { "x" : 199, "y" : 815 }, "b" : { "x" : 191, "y" : 812 }, "c" : { "x" : 192, "y" : 820 }, "type" : "ARROW", "centre" : { "x" : 192, "y" : 820 } }, "reactionShape" : { "c" : { "x" : 188, "y" : 857 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 188, "y" : 857 } }, "inputs" : [ { "id" : 99100, "points" : [ { "x" : 193, "y" : 907 } ] }, { "id" : 99103, "points" : [ { "x" : 277, "y" : 885 } ] } ], "outputs" : [ { "id" : 99104 } ] }, { "id" : 99105, "reactomeId" : 10289682, "displayName" : "SYK autophosphorylates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 201, "y" : 705 }, "minX" : 195, "maxX" : 213, "minY" : 678, "maxY" : 734, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 213, "y" : 734 }, "to" : { "x" : 201, "y" : 705 } }, { "from" : { "x" : 201, "y" : 705 }, "to" : { "x" : 213, "y" : 678 } } ], "reactionShape" : { "a" : { "x" : 195, "y" : 699 }, "b" : { "x" : 207, "y" : 711 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 201, "y" : 705 } }, "inputs" : [ { "id" : 99106, "points" : [ { "x" : 272, "y" : 741 } ], "stoichiometry" : 6 }, { "id" : 99104, "points" : [ { "x" : 193, "y" : 756 } ] } ], "outputs" : [ { "id" : 99107, "points" : [ { "x" : 272, "y" : 666 } ], "stoichiometry" : 6 }, { "id" : 99108, "points" : [ { "x" : 196, "y" : 651 } ] } ], "catalysts" : [ { "id" : 99104, "points" : [ { "x" : 172, "y" : 756 }, { "x" : 172, "y" : 704 } ] } ] }, { "id" : 99042, "reactomeId" : 10289050, "displayName" : "K63polyUb-TRAF6 ubiquitinates TAK1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3803, "y" : 554 }, "minX" : 3797, "maxX" : 3809, "minY" : 515, "maxY" : 581, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3803, "y" : 515 }, "to" : { "x" : 3803, "y" : 554 } }, { "from" : { "x" : 3803, "y" : 554 }, "to" : { "x" : 3803, "y" : 581 } } ], "reactionShape" : { "a" : { "x" : 3797, "y" : 548 }, "b" : { "x" : 3809, "y" : 560 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3803, "y" : 554 } }, "inputs" : [ { "id" : 99043, "points" : [ { "x" : 3688, "y" : 467 } ] }, { "id" : 99041, "points" : [ { "x" : 3803, "y" : 490 } ] }, { "id" : 99044, "points" : [ { "x" : 3705, "y" : 506 } ] }, { "id" : 99045, "points" : [ { "x" : 3748, "y" : 525 } ] } ], "outputs" : [ { "id" : 99046, "points" : [ { "x" : 3803, "y" : 620 } ] }, { "id" : 99047, "points" : [ { "x" : 3658, "y" : 618 } ] }, { "id" : 99048, "points" : [ { "x" : 3699, "y" : 583 } ] }, { "id" : 99045, "points" : [ { "x" : 3718, "y" : 549 } ] } ], "catalysts" : [ { "id" : 99041, "points" : [ { "x" : 3867, "y" : 452 }, { "x" : 3896, "y" : 452 }, { "x" : 3896, "y" : 553 } ] } ] }, { "id" : 98978, "reactomeId" : 10289030, "displayName" : "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 522, "y" : 51 }, "minX" : 494, "maxX" : 550, "minY" : 45, "maxY" : 57, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 494, "y" : 51 }, "to" : { "x" : 522, "y" : 51 } }, { "from" : { "x" : 522, "y" : 51 }, "to" : { "x" : 550, "y" : 51 } } ], "reactionShape" : { "a" : { "x" : 516, "y" : 45 }, "b" : { "x" : 528, "y" : 57 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 522, "y" : 51 } }, "inputs" : [ { "id" : 98979, "points" : [ { "x" : 465, "y" : 100 } ] }, { "id" : 98980, "points" : [ { "x" : 469, "y" : 51 } ] } ], "outputs" : [ { "id" : 98981, "points" : [ { "x" : 586, "y" : 51 } ] }, { "id" : 98982, "points" : [ { "x" : 584, "y" : 112 } ] } ], "catalysts" : [ { "id" : 98983, "points" : [ { "x" : 522, "y" : 144 } ] } ] }, { "id" : 99109, "reactomeId" : 10289675, "displayName" : "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 201, "y" : 368 }, "minX" : 195, "maxX" : 224, "minY" : 347, "maxY" : 387, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 224, "y" : 387 }, "to" : { "x" : 201, "y" : 368 } }, { "from" : { "x" : 201, "y" : 368 }, "to" : { "x" : 224, "y" : 347 } } ], "reactionShape" : { "a" : { "x" : 195, "y" : 362 }, "b" : { "x" : 207, "y" : 374 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 201, "y" : 368 } }, "inputs" : [ { "id" : 99110, "points" : [ { "x" : 272, "y" : 415 } ], "stoichiometry" : 2 }, { "id" : 99111, "points" : [ { "x" : 201, "y" : 411 } ] } ], "outputs" : [ { "id" : 99112, "points" : [ { "x" : 272, "y" : 336 } ], "stoichiometry" : 2 }, { "id" : 99113, "points" : [ { "x" : 203, "y" : 325 } ] } ], "catalysts" : [ { "id" : 99111, "points" : [ { "x" : 174, "y" : 411 }, { "x" : 174, "y" : 368 } ] } ] }, { "id" : 99049, "reactomeId" : 10288974, "displayName" : "K63polyUb-TAK1 autophosphorylates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3803, "y" : 752 }, "minX" : 3797, "maxX" : 3809, "minY" : 719, "maxY" : 785, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3803, "y" : 719 }, "to" : { "x" : 3803, "y" : 752 } }, { "from" : { "x" : 3803, "y" : 752 }, "to" : { "x" : 3803, "y" : 785 } } ], "reactionShape" : { "a" : { "x" : 3797, "y" : 746 }, "b" : { "x" : 3809, "y" : 758 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3803, "y" : 752 } }, "inputs" : [ { "id" : 99050, "points" : [ { "x" : 3704, "y" : 702 } ], "stoichiometry" : 4 }, { "id" : 99046, "points" : [ { "x" : 3803, "y" : 690 } ] } ], "outputs" : [ { "id" : 99051, "points" : [ { "x" : 3696, "y" : 791 } ], "stoichiometry" : 4 }, { "id" : 99052, "points" : [ { "x" : 3803, "y" : 810 } ] } ], "catalysts" : [ { "id" : 99046, "points" : [ { "x" : 3898, "y" : 653 }, { "x" : 3937, "y" : 653 }, { "x" : 3937, "y" : 752 } ] } ] }, { "id" : 98984, "reactomeId" : 10289042, "displayName" : "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1035, "y" : 110 }, "minX" : 995, "maxX" : 1071, "minY" : 67, "maxY" : 116, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 995, "y" : 110 }, "to" : { "x" : 1035, "y" : 110 } }, { "from" : { "x" : 1035, "y" : 110 }, "to" : { "x" : 1071, "y" : 67 } } ], "endShape" : { "a" : { "x" : 1070, "y" : 75 }, "b" : { "x" : 1071, "y" : 67 }, "c" : { "x" : 1063, "y" : 70 }, "type" : "ARROW", "centre" : { "x" : 1063, "y" : 70 } }, "reactionShape" : { "a" : { "x" : 1029, "y" : 104 }, "b" : { "x" : 1041, "y" : 116 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1035, "y" : 110 } }, "inputs" : [ { "id" : 98985 } ], "outputs" : [ { "id" : 98986 } ] }, { "id" : 98987, "reactomeId" : 10288987, "displayName" : "p-Y753,Y759-PLCG2 hydrolyses PIP2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1263, "y" : 78 }, "minX" : 1223, "maxX" : 1290, "minY" : 72, "maxY" : 84, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1223, "y" : 78 }, "to" : { "x" : 1263, "y" : 78 } }, { "from" : { "x" : 1263, "y" : 78 }, "to" : { "x" : 1290, "y" : 78 } } ], "reactionShape" : { "a" : { "x" : 1257, "y" : 72 }, "b" : { "x" : 1269, "y" : 84 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1263, "y" : 78 } }, "inputs" : [ { "id" : 98988, "points" : [ { "x" : 1207, "y" : 63 } ] }, { "id" : 98989, "points" : [ { "x" : 1198, "y" : 111 } ] } ], "outputs" : [ { "id" : 98990, "points" : [ { "x" : 1324, "y" : 112 } ] }, { "id" : 98991, "points" : [ { "x" : 1311, "y" : 63 } ] } ], "catalysts" : [ { "id" : 98986, "points" : [ { "x" : 1085, "y" : 25 }, { "x" : 1085, "y" : 3 }, { "x" : 1262, "y" : 3 } ] } ] }, { "id" : 99115, "reactomeId" : 10289659, "displayName" : "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 720, "y" : 1474 }, "minX" : 698, "maxX" : 793, "minY" : 1448, "maxY" : 1480, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 698, "y" : 1475 }, "to" : { "x" : 720, "y" : 1474 } }, { "from" : { "x" : 720, "y" : 1474 }, "to" : { "x" : 740, "y" : 1475 } }, { "from" : { "x" : 740, "y" : 1475 }, "to" : { "x" : 793, "y" : 1448 } } ], "endShape" : { "a" : { "x" : 789, "y" : 1455 }, "b" : { "x" : 793, "y" : 1448 }, "c" : { "x" : 785, "y" : 1448 }, "type" : "ARROW", "centre" : { "x" : 785, "y" : 1448 } }, "reactionShape" : { "c" : { "x" : 720, "y" : 1474 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 720, "y" : 1474 } }, "inputs" : [ { "id" : 99116, "points" : [ { "x" : 638, "y" : 1450 } ] }, { "id" : 99117, "points" : [ { "x" : 692, "y" : 1450 } ] } ], "outputs" : [ { "id" : 99118 } ] }, { "id" : 99114, "reactomeId" : 10289649, "displayName" : "PLCG2 translocates from cytosol to plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 370, "y" : 283 }, "minX" : 239, "maxX" : 449, "minY" : 277, "maxY" : 289, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 239, "y" : 283 }, "to" : { "x" : 370, "y" : 283 } }, { "from" : { "x" : 370, "y" : 283 }, "to" : { "x" : 449, "y" : 283 } } ], "reactionShape" : { "c" : { "x" : 370, "y" : 283 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 370, "y" : 283 } }, "inputs" : [ { "id" : 99113 } ], "outputs" : [ { "id" : 99108, "points" : [ { "x" : 247, "y" : 616 }, { "x" : 366, "y" : 616 } ] }, { "id" : 98986, "points" : [ { "x" : 1086, "y" : 67 }, { "x" : 1088, "y" : 196 } ] } ] }, { "id" : 99053, "reactomeId" : 10289009, "displayName" : "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3397, "y" : 415 }, "minX" : 3373, "maxX" : 3424, "minY" : 409, "maxY" : 421, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3424, "y" : 415 }, "to" : { "x" : 3397, "y" : 415 } }, { "from" : { "x" : 3397, "y" : 415 }, "to" : { "x" : 3373, "y" : 415 } } ], "reactionShape" : { "a" : { "x" : 3391, "y" : 409 }, "b" : { "x" : 3403, "y" : 421 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3397, "y" : 415 } }, "inputs" : [ { "id" : 99054, "points" : [ { "x" : 3446, "y" : 366 } ], "stoichiometry" : 2 }, { "id" : 99055, "points" : [ { "x" : 3443, "y" : 415 } ] } ], "outputs" : [ { "id" : 99056, "points" : [ { "x" : 3348, "y" : 415 } ] }, { "id" : 99057, "points" : [ { "x" : 3347, "y" : 362 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 99052, "points" : [ { "x" : 3700, "y" : 846 }, { "x" : 3627, "y" : 846 }, { "x" : 3396, "y" : 536 } ] } ] }, { "id" : 99119, "reactomeId" : 10289928, "displayName" : "RAF1 binds p21 RAS:GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2538, "y" : 1429 }, "minX" : 2513, "maxX" : 2589, "minY" : 1423, "maxY" : 1443, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2513, "y" : 1443 }, "to" : { "x" : 2538, "y" : 1429 } }, { "from" : { "x" : 2538, "y" : 1429 }, "to" : { "x" : 2564, "y" : 1443 } }, { "from" : { "x" : 2564, "y" : 1443 }, "to" : { "x" : 2589, "y" : 1443 } } ], "endShape" : { "a" : { "x" : 2582, "y" : 1447 }, "b" : { "x" : 2589, "y" : 1443 }, "c" : { "x" : 2582, "y" : 1439 }, "type" : "ARROW", "centre" : { "x" : 2582, "y" : 1439 } }, "reactionShape" : { "c" : { "x" : 2538, "y" : 1429 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2538, "y" : 1429 } }, "inputs" : [ { "id" : 99120, "points" : [ { "x" : 2487, "y" : 1443 } ] }, { "id" : 99121, "points" : [ { "x" : 2501, "y" : 1386 } ] } ], "outputs" : [ { "id" : 99122 } ] }, { "id" : 98992, "reactomeId" : 10280730, "displayName" : "Activation of Calcineurin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 907, "y" : 353 }, "minX" : 875, "maxX" : 939, "minY" : 347, "maxY" : 359, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 939, "y" : 353 }, "to" : { "x" : 907, "y" : 353 } }, { "from" : { "x" : 907, "y" : 353 }, "to" : { "x" : 875, "y" : 353 } } ], "endShape" : { "a" : { "x" : 882, "y" : 349 }, "b" : { "x" : 875, "y" : 353 }, "c" : { "x" : 882, "y" : 357 }, "type" : "ARROW", "centre" : { "x" : 882, "y" : 357 } }, "reactionShape" : { "c" : { "x" : 907, "y" : 353 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 907, "y" : 353 } }, "inputs" : [ { "id" : 98993, "points" : [ { "x" : 968, "y" : 331 } ] }, { "id" : 98994, "points" : [ { "x" : 1130, "y" : 342 }, { "x" : 1098, "y" : 353 } ], "stoichiometry" : 4 }, { "id" : 98995, "points" : [ { "x" : 967, "y" : 377 } ] } ], "outputs" : [ { "id" : 98996 } ] }, { "id" : 99123, "reactomeId" : 10289926, "displayName" : "PAK phosphorylates p21 RAF1 on S338", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2725, "y" : 1431 }, "minX" : 2688, "maxX" : 2752, "minY" : 1407, "maxY" : 1437, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2688, "y" : 1407 }, "to" : { "x" : 2725, "y" : 1431 } }, { "from" : { "x" : 2725, "y" : 1431 }, "to" : { "x" : 2752, "y" : 1407 } } ], "reactionShape" : { "a" : { "x" : 2719, "y" : 1425 }, "b" : { "x" : 2731, "y" : 1437 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2725, "y" : 1431 } }, "inputs" : [ { "id" : 99122, "points" : [ { "x" : 2664, "y" : 1429 } ] }, { "id" : 99124, "points" : [ { "x" : 2669, "y" : 1378 } ] } ], "outputs" : [ { "id" : 99125, "points" : [ { "x" : 2784, "y" : 1366 } ] }, { "id" : 99126, "points" : [ { "x" : 2783, "y" : 1427 } ] } ], "catalysts" : [ { "id" : 99127, "points" : [ { "x" : 2735, "y" : 1330 } ] } ] }, { "id" : 99058, "reactomeId" : 10288903, "displayName" : "Activation of NIK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1897, "y" : 672 }, "minX" : 1877, "maxX" : 1930, "minY" : 666, "maxY" : 678, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1877, "y" : 672 }, "to" : { "x" : 1897, "y" : 672 } }, { "from" : { "x" : 1897, "y" : 672 }, "to" : { "x" : 1930, "y" : 672 } } ], "reactionShape" : { "a" : { "x" : 1891, "y" : 666 }, "b" : { "x" : 1903, "y" : 678 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1897, "y" : 672 } }, "inputs" : [ { "id" : 99059 } ] }, { "id" : 98997, "reactomeId" : 10280623, "displayName" : "Calcineurin binds and dephosphorylates NFAT", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 704, "y" : 355 }, "minX" : 669, "maxX" : 734, "minY" : 349, "maxY" : 361, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 734, "y" : 355 }, "to" : { "x" : 704, "y" : 355 } }, { "from" : { "x" : 704, "y" : 355 }, "to" : { "x" : 669, "y" : 355 } } ], "reactionShape" : { "a" : { "x" : 698, "y" : 349 }, "b" : { "x" : 710, "y" : 361 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 704, "y" : 355 } }, "inputs" : [ { "id" : 98998, "points" : [ { "x" : 764, "y" : 390 } ] }, { "id" : 98999, "points" : [ { "x" : 762, "y" : 318 } ] }, { "id" : 98996, "points" : [ { "x" : 760, "y" : 355 } ] } ], "outputs" : [ { "id" : 99000, "points" : [ { "x" : 643, "y" : 388 } ] }, { "id" : 99001, "points" : [ { "x" : 637, "y" : 329 } ], "stoichiometry" : 13 } ], "catalysts" : [ { "id" : 98996, "points" : [ { "x" : 816, "y" : 383 }, { "x" : 816, "y" : 436 }, { "x" : 706, "y" : 435 } ] } ] }, { "id" : 99060, "reactomeId" : 10288908, "displayName" : "Active NIK phosphorylates IKKA dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2058, "y" : 672 }, "minX" : 2031, "maxX" : 2089, "minY" : 666, "maxY" : 678, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2031, "y" : 672 }, "to" : { "x" : 2058, "y" : 672 } }, { "from" : { "x" : 2058, "y" : 672 }, "to" : { "x" : 2089, "y" : 672 } } ], "reactionShape" : { "a" : { "x" : 2052, "y" : 666 }, "b" : { "x" : 2064, "y" : 678 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2058, "y" : 672 } }, "inputs" : [ { "id" : 99061, "points" : [ { "x" : 2001, "y" : 696 } ], "stoichiometry" : 4 }, { "id" : 99062, "points" : [ { "x" : 2016, "y" : 742 } ] }, { "id" : 99063, "points" : [ { "x" : 2005, "y" : 672 } ] } ], "outputs" : [ { "id" : 99064, "points" : [ { "x" : 2110, "y" : 625 } ], "stoichiometry" : 4 }, { "id" : 99065, "points" : [ { "x" : 2122, "y" : 672 } ] } ], "catalysts" : [ { "id" : 99063, "points" : [ { "x" : 1967, "y" : 658 }, { "x" : 1967, "y" : 633 }, { "x" : 2058, "y" : 633 } ] } ] }, { "id" : 99128, "reactomeId" : 10289921, "displayName" : "SFKs phosphorylates RAF1 on Y340,Y341", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2882, "y" : 1437 }, "minX" : 2855, "maxX" : 2904, "minY" : 1409, "maxY" : 1443, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2855, "y" : 1409 }, "to" : { "x" : 2882, "y" : 1437 } }, { "from" : { "x" : 2882, "y" : 1437 }, "to" : { "x" : 2904, "y" : 1409 } } ], "reactionShape" : { "a" : { "x" : 2876, "y" : 1431 }, "b" : { "x" : 2888, "y" : 1443 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2882, "y" : 1437 } }, "inputs" : [ { "id" : 99126, "points" : [ { "x" : 2829, "y" : 1427 } ] }, { "id" : 99129, "points" : [ { "x" : 2846, "y" : 1362 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 99130, "points" : [ { "x" : 2932, "y" : 1362 } ], "stoichiometry" : 2 }, { "id" : 99131, "points" : [ { "x" : 2941, "y" : 1424 } ] } ], "catalysts" : [ { "id" : 99132, "points" : [ { "x" : 2892, "y" : 1325 } ] } ] }, { "id" : 99002, "reactomeId" : 10280718, "displayName" : "Translocation of CaN:CaM:NFAT to nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 637, "y" : 480 }, "minX" : 631, "maxX" : 1365, "minY" : 416, "maxY" : 843, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 636, "y" : 416 }, "to" : { "x" : 637, "y" : 480 } }, { "from" : { "x" : 637, "y" : 480 }, "to" : { "x" : 1365, "y" : 843 } } ], "endShape" : { "a" : { "x" : 1357, "y" : 843 }, "b" : { "x" : 1365, "y" : 843 }, "c" : { "x" : 1361, "y" : 836 }, "type" : "ARROW", "centre" : { "x" : 1361, "y" : 836 } }, "reactionShape" : { "a" : { "x" : 631, "y" : 474 }, "b" : { "x" : 643, "y" : 486 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 637, "y" : 480 } }, "inputs" : [ { "id" : 99000 } ], "outputs" : [ { "id" : 99003 } ] }, { "id" : 99066, "reactomeId" : 10288901, "displayName" : "p100:RELB binds active NIK:p-IKKA dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2296, "y" : 673 }, "minX" : 2273, "maxX" : 2312, "minY" : 667, "maxY" : 702, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2273, "y" : 673 }, "to" : { "x" : 2296, "y" : 673 } }, { "from" : { "x" : 2296, "y" : 673 }, "to" : { "x" : 2312, "y" : 702 } } ], "endShape" : { "a" : { "x" : 2305, "y" : 698 }, "b" : { "x" : 2312, "y" : 702 }, "c" : { "x" : 2312, "y" : 694 }, "type" : "ARROW", "centre" : { "x" : 2312, "y" : 694 } }, "reactionShape" : { "c" : { "x" : 2296, "y" : 673 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2296, "y" : 673 } }, "inputs" : [ { "id" : 99067, "points" : [ { "x" : 2232, "y" : 709 } ] }, { "id" : 99065, "points" : [ { "x" : 2254, "y" : 673 } ] } ], "outputs" : [ { "id" : 99068 } ] }, { "id" : 99133, "reactomeId" : 10292027, "displayName" : "Caspase-8 binds MALT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2729, "y" : 194 }, "minX" : 2723, "maxX" : 2735, "minY" : 163, "maxY" : 230, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2729, "y" : 163 }, "to" : { "x" : 2729, "y" : 194 } }, { "from" : { "x" : 2729, "y" : 194 }, "to" : { "x" : 2729, "y" : 230 } } ], "endShape" : { "a" : { "x" : 2725, "y" : 223 }, "b" : { "x" : 2729, "y" : 230 }, "c" : { "x" : 2733, "y" : 223 }, "type" : "ARROW", "centre" : { "x" : 2733, "y" : 223 } }, "reactionShape" : { "c" : { "x" : 2729, "y" : 194 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2729, "y" : 194 } }, "inputs" : [ { "id" : 99134, "points" : [ { "x" : 2700, "y" : 142 } ] }, { "id" : 99023, "points" : [ { "x" : 2760, "y" : 143 } ] } ], "outputs" : [ { "id" : 99135 } ] }, { "id" : 99069, "reactomeId" : 10288936, "displayName" : "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2413, "y" : 666 }, "minX" : 2371, "maxX" : 2450, "minY" : 660, "maxY" : 672, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2371, "y" : 666 }, "to" : { "x" : 2413, "y" : 666 } }, { "from" : { "x" : 2413, "y" : 666 }, "to" : { "x" : 2450, "y" : 666 } } ], "reactionShape" : { "a" : { "x" : 2407, "y" : 660 }, "b" : { "x" : 2419, "y" : 672 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2413, "y" : 666 } }, "inputs" : [ { "id" : 99070, "points" : [ { "x" : 2338, "y" : 642 } ], "stoichiometry" : 7 }, { "id" : 99068, "points" : [ { "x" : 2343, "y" : 702 } ] } ], "outputs" : [ { "id" : 99071, "points" : [ { "x" : 2465, "y" : 703 } ], "stoichiometry" : 7 }, { "id" : 99072, "points" : [ { "x" : 2558, "y" : 565 } ] } ], "catalysts" : [ { "id" : 99068, "points" : [ { "x" : 2389, "y" : 725 }, { "x" : 2387, "y" : 725 }, { "x" : 2412, "y" : 725 } ] } ] }, { "id" : 99004, "reactomeId" : 10288982, "displayName" : "PKC-delta translocates to plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1414, "y" : 45 }, "minX" : 1383, "maxX" : 1480, "minY" : 39, "maxY" : 70, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1383, "y" : 70 }, "to" : { "x" : 1414, "y" : 45 } }, { "from" : { "x" : 1414, "y" : 45 }, "to" : { "x" : 1439, "y" : 70 } }, { "from" : { "x" : 1439, "y" : 70 }, "to" : { "x" : 1480, "y" : 60 } } ], "endShape" : { "a" : { "x" : 1474, "y" : 66 }, "b" : { "x" : 1480, "y" : 60 }, "c" : { "x" : 1472, "y" : 58 }, "type" : "ARROW", "centre" : { "x" : 1472, "y" : 58 } }, "reactionShape" : { "c" : { "x" : 1414, "y" : 45 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1414, "y" : 45 } }, "inputs" : [ { "id" : 99005, "points" : [ { "x" : 1425, "y" : 152 } ] }, { "id" : 98991, "points" : [ { "x" : 1358, "y" : 57 } ] } ], "outputs" : [ { "id" : 99006 } ] }, { "id" : 99007, "reactomeId" : 10289013, "displayName" : "PKC-delta is activated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1659, "y" : 44 }, "minX" : 1619, "maxX" : 1697, "minY" : 38, "maxY" : 50, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1619, "y" : 44 }, "to" : { "x" : 1659, "y" : 44 } }, { "from" : { "x" : 1659, "y" : 44 }, "to" : { "x" : 1697, "y" : 44 } } ], "endShape" : { "a" : { "x" : 1690, "y" : 48 }, "b" : { "x" : 1697, "y" : 44 }, "c" : { "x" : 1690, "y" : 40 }, "type" : "ARROW", "centre" : { "x" : 1690, "y" : 40 } }, "reactionShape" : { "a" : { "x" : 1653, "y" : 38 }, "b" : { "x" : 1665, "y" : 50 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1659, "y" : 44 } }, "inputs" : [ { "id" : 99006 } ], "outputs" : [ { "id" : 99008 } ] } ], "compartments" : [ { "id" : 99154, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1994, "y" : 756 }, "minX" : 179, "maxX" : 3809, "minY" : 46, "maxY" : 1466, "prop" : { "x" : 179, "y" : 46, "width" : 3630, "height" : 1420 }, "textPosition" : { "x" : 714, "y" : 557 }, "insets" : { "x" : 189, "y" : 56, "width" : 3610, "height" : 1400 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 98980, 98979, 98981, 98982, 98983, 98985, 98986, 98988, 98989, 98990, 98991, 98994, 98993, 98995, 98998, 98999, 99000, 99001, 99005, 99006, 99008, 99010, 99011, 99012, 99013, 99015, 99016, 99018, 99019, 99021, 99023, 99024, 99026, 99028, 99029, 99031, 99033, 99088, 99034, 99036, 99037, 99038, 99040, 99041, 99043, 99046, 99047, 99048, 99044, 99050, 99051, 99052, 99054, 99055, 99056, 99057, 99090, 99074, 99063, 99159, 99064, 99065, 99067, 99068, 99070, 99071, 99072, 99075, 99077, 99078, 99080, 99079, 99082, 99083, 99084, 99160, 98978, 98984, 98987, 98992, 98997, 99002, 99009, 99039, 99042, 99049, 99053, 99058, 99060, 99066, 99069, 99073, 99076, 99081, 99087, 99091, 99035, 98996, 99089, 99100, 99101, 99098, 99099, 99102, 99104, 99103, 99105, 99106, 99107, 99111, 99109, 99110, 99112, 99113, 99108, 99114, 99092, 99094, 99095, 99097, 99181, 99116, 99118, 99120, 99119, 99121, 99122, 99123, 99124, 99125, 99126, 99127, 99128, 99129, 99130, 99131, 99132, 99117, 99045, 99133, 99134, 99135, 99136, 99137, 99138, 99142, 99141, 99139, 99140, 99085, 99059, 99061, 99062, 99032, 99093, 99183 ] }, { "id" : 99159, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1331, "y" : 377 }, "minX" : 1208, "maxX" : 1455, "minY" : 283, "maxY" : 471, "prop" : { "x" : 1208, "y" : 283, "width" : 247, "height" : 188 }, "textPosition" : { "x" : 1248, "y" : 421 }, "insets" : { "x" : 1218, "y" : 293, "width" : 227, "height" : 168 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 99174, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1626, "y" : 1589 }, "minX" : 1481, "maxX" : 1772, "minY" : 1541, "maxY" : 1637, "prop" : { "x" : 1481, "y" : 1541, "width" : 291, "height" : 96 }, "textPosition" : { "x" : 1597, "y" : 1572 }, "insets" : { "x" : 1491, "y" : 1551, "width" : 271, "height" : 76 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 99160, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1801, "y" : 1029 }, "minX" : 1297, "maxX" : 2306, "minY" : 817, "maxY" : 1241, "prop" : { "x" : 1297, "y" : 817, "width" : 1009, "height" : 424 }, "textPosition" : { "x" : 1653, "y" : 994 }, "insets" : { "x" : 1307, "y" : 827, "width" : 989, "height" : 404 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 99086, 99146, 99144, 99145, 99143, 99003 ] } ], "notes" : [ ], "links" : [ { "id" : 99181, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 279, "y" : 1124 }, "minX" : 248, "maxX" : 298, "minY" : 1118, "maxY" : 1326, "segments" : [ { "from" : { "x" : 298, "y" : 1326 }, "to" : { "x" : 279, "y" : 1124 } }, { "from" : { "x" : 279, "y" : 1124 }, "to" : { "x" : 248, "y" : 1124 } } ], "reactionShape" : { "a" : { "x" : 273, "y" : 1118 }, "b" : { "x" : 285, "y" : 1130 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 279, "y" : 1124 } }, "inputs" : [ { "id" : 99095 } ], "outputs" : [ { "id" : 99097 } ] }, { "id" : 99183, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 592, "y" : 1431 }, "minX" : 519, "maxX" : 665, "minY" : 1425, "maxY" : 1437, "segments" : [ { "from" : { "x" : 665, "y" : 1431 }, "to" : { "x" : 519, "y" : 1431 } } ], "reactionShape" : { "a" : { "x" : 586, "y" : 1425 }, "b" : { "x" : 598, "y" : 1437 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 592, "y" : 1431 } }, "inputs" : [ { "id" : 99117 } ], "outputs" : [ { "id" : 99093 } ] }, { "id" : 99182, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 105, "y" : 1391 }, "minX" : 58, "maxX" : 382, "minY" : 1299, "maxY" : 1423, "segments" : [ { "from" : { "x" : 58, "y" : 1299 }, "to" : { "x" : 105, "y" : 1391 } }, { "from" : { "x" : 105, "y" : 1391 }, "to" : { "x" : 382, "y" : 1423 } } ], "reactionShape" : { "a" : { "x" : 99, "y" : 1385 }, "b" : { "x" : 111, "y" : 1397 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 105, "y" : 1391 } }, "inputs" : [ { "id" : 99163 } ], "outputs" : [ { "id" : 99093 } ] } ], "shadows" : [ { "id" : 99185, "reactomeId" : 10331197, "displayName" : "Dectin-2 family", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 622, "y" : 754 }, "minX" : 97, "maxX" : 1147, "minY" : 18, "maxY" : 1490, "prop" : { "x" : 97, "y" : 973, "width" : 1050, "height" : 517 }, "points" : [ { "x" : 97, "y" : 18 }, { "x" : 1147, "y" : 18 }, { "x" : 1147, "y" : 1490 }, { "x" : 97, "y" : 1490 } ], "colour" : "#dc3912" }, { "id" : 99184, "reactomeId" : 10329869, "displayName" : "CLEC7A (Dectin-1) signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2134, "y" : 491 }, "minX" : 354, "maxX" : 3914, "minY" : 10, "maxY" : 973, "prop" : { "x" : 1147, "y" : 18, "width" : 2767, "height" : 955 }, "points" : [ { "x" : 354, "y" : 10 }, { "x" : 3914, "y" : 10 }, { "x" : 3914, "y" : 973 }, { "x" : 354, "y" : 973 } ], "colour" : "#4684ee" }, { "id" : 99186, "reactomeId" : 10331201, "displayName" : "CD209 (DC-SIGN) signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2232, "y" : 1252 }, "minX" : 1403, "maxX" : 3061, "minY" : 1017, "maxY" : 1487, "prop" : { "x" : 1403, "y" : 1017, "width" : 1658, "height" : 470 }, "points" : [ { "x" : 1403, "y" : 1017 }, { "x" : 3061, "y" : 1017 }, { "x" : 3061, "y" : 1487 }, { "x" : 1403, "y" : 1487 } ], "colour" : "#008000" } ], "minX" : 0, "maxX" : 3937, "minY" : 0, "maxY" : 1637, "disease" : false }