{
  "dbId" : 10329823,
  "stId" : "R-CFA-202403",
  "speciesName" : "Canis familiaris",
  "nodes" : [ {
    "dbId" : 10231196,
    "stId" : "R-CFA-74787",
    "displayName" : "PIK3CA [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A5F4C2B1",
    "standardIdentifier" : "uniprot:A0A5F4C2B1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3CA" ],
    "parents" : [ 10231202 ],
    "children" : [ ]
  }, {
    "dbId" : 10245279,
    "stId" : "R-CFA-202346",
    "displayName" : "PRKCQ [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RRL7",
    "standardIdentifier" : "uniprot:A0A8I3RRL7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PRKCQ" ],
    "parents" : [ 10245281 ],
    "children" : [ ]
  }, {
    "dbId" : 202247,
    "stId" : "R-ALL-202247",
    "displayName" : "PI(3,4)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84525 ],
    "identifier" : "16152",
    "standardIdentifier" : "chebi:16152",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 202277 ],
    "children" : [ ]
  }, {
    "dbId" : 10231192,
    "stId" : "R-CFA-74688",
    "displayName" : "PI3K-regulatory subunit [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10231204 ],
    "children" : [ 10231186, 10231190 ]
  }, {
    "dbId" : 10307994,
    "stId" : "R-CFA-8855376",
    "displayName" : "PTPN22:CSK [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84604 ],
    "parents" : [ ],
    "children" : [ 10245223, 10307397 ]
  }, {
    "dbId" : 10231190,
    "stId" : "R-CFA-74791",
    "displayName" : "PIK3R2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3S3N2",
    "standardIdentifier" : "uniprot:A0A8I3S3N2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3R2" ],
    "parents" : [ 10231192 ],
    "children" : [ ]
  }, {
    "dbId" : 10242455,
    "stId" : "R-CFA-168114",
    "displayName" : "IKBKB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N4F2",
    "standardIdentifier" : "uniprot:A0A8I3N4F2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKB" ],
    "parents" : [ 10245377 ],
    "children" : [ ]
  }, {
    "dbId" : 10245271,
    "stId" : "R-CFA-8866028",
    "displayName" : "CD101 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84500 ],
    "identifier" : "A0A8I3Q5D2",
    "standardIdentifier" : "uniprot:A0A8I3Q5D2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD101" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245264,
    "stId" : "R-CFA-202359",
    "displayName" : "ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84488 ],
    "parents" : [ 10245266 ],
    "children" : [ 10245203, 10245262 ]
  }, {
    "dbId" : 10231186,
    "stId" : "R-CFA-74789",
    "displayName" : "PIK3R1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N971",
    "standardIdentifier" : "uniprot:A0A8I3N971",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3R1" ],
    "parents" : [ 10231192 ],
    "children" : [ ]
  }, {
    "dbId" : 10245266,
    "stId" : "R-CFA-202282",
    "displayName" : "ZAP-70 and ITK tyrosine kinases [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 84499 ],
    "parents" : [ ],
    "children" : [ 10245264, 10245133 ]
  }, {
    "dbId" : 10245262,
    "stId" : "R-CFA-202319",
    "displayName" : "ITK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84487 ],
    "identifier" : "A0A8I3MMK2",
    "standardIdentifier" : "uniprot:A0A8I3MMK2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ITK" ],
    "parents" : [ 10245264 ],
    "children" : [ ]
  }, {
    "dbId" : 10240654,
    "stId" : "R-CFA-180494",
    "displayName" : "phospho-PAG1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84440 ],
    "identifier" : "A0A8I3NYA3",
    "standardIdentifier" : "uniprot:A0A8I3NYA3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PAG1" ],
    "parents" : [ 10245225 ],
    "children" : [ ]
  }, {
    "dbId" : 10245256,
    "stId" : "R-CFA-202302",
    "displayName" : "phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84505 ],
    "parents" : [ 10245258 ],
    "children" : [ 10245203, 10245252 ]
  }, {
    "dbId" : 10245258,
    "stId" : "R-CFA-202193",
    "displayName" : "Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 84497 ],
    "parents" : [ ],
    "children" : [ 10245254, 10245256 ]
  }, {
    "dbId" : 10245252,
    "stId" : "R-CFA-202357",
    "displayName" : "phospho-PLCG1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84503 ],
    "identifier" : "A0A8I3SCI7",
    "standardIdentifier" : "uniprot:A0A8I3SCI7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PLCG1" ],
    "parents" : [ 10245256, 10245254 ],
    "children" : [ ]
  }, {
    "dbId" : 10245254,
    "stId" : "R-CFA-202310",
    "displayName" : "phosphorylated PLC-gamma1 bound to LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84502 ],
    "parents" : [ 10245258 ],
    "children" : [ 10245158, 10245252 ]
  }, {
    "dbId" : 10238140,
    "stId" : "R-CFA-166366",
    "displayName" : "TRAF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84570 ],
    "identifier" : "A0A8I3P2V4",
    "standardIdentifier" : "uniprot:A0A8I3P2V4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10245350 ],
    "children" : [ ]
  }, {
    "dbId" : 10245309,
    "stId" : "R-CFA-202349",
    "displayName" : "CARMA1 bound to PDK1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84547 ],
    "parents" : [ ],
    "children" : [ 10245042, 10245307 ]
  }, {
    "dbId" : 10245055,
    "stId" : "R-CFA-197576",
    "displayName" : "DLA-DQA1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3S023",
    "standardIdentifier" : "uniprot:A0A8I3S023",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DLA-DQA1" ],
    "parents" : [ 10245063 ],
    "children" : [ ]
  }, {
    "dbId" : 10243519,
    "stId" : "R-CFA-198180",
    "displayName" : "TRAV29DV5 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MED5",
    "standardIdentifier" : "uniprot:A0A8I3MED5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAV29DV5" ],
    "parents" : [ 10243525 ],
    "children" : [ ]
  }, {
    "dbId" : 10245049,
    "stId" : "R-CFA-202308",
    "displayName" : "phospho-LCK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NAC6",
    "standardIdentifier" : "uniprot:A0A8I3NAC6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LCK" ],
    "parents" : [ 10245081, 10245111 ],
    "children" : [ ]
  }, {
    "dbId" : 202277,
    "stId" : "R-ALL-202277",
    "displayName" : "PIP3, PI(3,4)P2 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 84529 ],
    "parents" : [ 10245042 ],
    "children" : [ 179838, 202247 ]
  }, {
    "dbId" : 10238394,
    "stId" : "R-CFA-168402",
    "displayName" : "RIPK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84562 ],
    "identifier" : "A0A8I3PFI5",
    "standardIdentifier" : "uniprot:A0A8I3PFI5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RIPK2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245307,
    "stId" : "R-CFA-202161",
    "displayName" : "CARD11 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84546 ],
    "identifier" : "A0A8I3NT57",
    "standardIdentifier" : "uniprot:A0A8I3NT57",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CARD11" ],
    "parents" : [ 10245309 ],
    "children" : [ ]
  }, {
    "dbId" : 10245051,
    "stId" : "R-CFA-167542",
    "displayName" : "Ghost homologue of CD4 [plasma membrane]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 49646,
    "parents" : [ 10245167, 10245171, 10245081, 10245111 ],
    "children" : [ ]
  }, {
    "dbId" : 10245040,
    "stId" : "R-CFA-202210",
    "displayName" : "PDPK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84530 ],
    "identifier" : "A0A8I3MQX7",
    "standardIdentifier" : "uniprot:A0A8I3MQX7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PDPK1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245296,
    "stId" : "R-CFA-202269",
    "displayName" : "Activated PLC gamma1 bound to PIP2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84508 ],
    "parents" : [ ],
    "children" : [ 179856, 10245294 ]
  }, {
    "dbId" : 10244017,
    "stId" : "R-CFA-199420",
    "displayName" : "PTEN [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84610 ],
    "identifier" : "P60483",
    "standardIdentifier" : "uniprot:P60483",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PTEN" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245042,
    "stId" : "R-CFA-202311",
    "displayName" : "PDK1:PIP2,PIP3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84531 ],
    "parents" : [ 10245309, 10245326, 10245331 ],
    "children" : [ 10233414, 202277 ]
  }, {
    "dbId" : 10245294,
    "stId" : "R-CFA-167679",
    "displayName" : "phospho-PLCG1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3SCI7",
    "standardIdentifier" : "uniprot:A0A8I3SCI7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PLCG1" ],
    "parents" : [ 10245296, 10245318 ],
    "children" : [ ]
  }, {
    "dbId" : 10231204,
    "stId" : "R-CFA-74693",
    "displayName" : "PI3K [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84516 ],
    "parents" : [ 10245145 ],
    "children" : [ 10231202, 10231192 ]
  }, {
    "dbId" : 10231200,
    "stId" : "R-CFA-74788",
    "displayName" : "PIK3CB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PWT3",
    "standardIdentifier" : "uniprot:A0A8I3PWT3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PIK3CB" ],
    "parents" : [ 10231202 ],
    "children" : [ ]
  }, {
    "dbId" : 10245281,
    "stId" : "R-CFA-202187",
    "displayName" : "PKC-theta (open): DAG [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84535 ],
    "parents" : [ ],
    "children" : [ 10245279, 112275 ]
  }, {
    "dbId" : 10231202,
    "stId" : "R-CFA-74689",
    "displayName" : "PI3K-catalytic subunit [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10231204 ],
    "children" : [ 10231200, 10231196 ]
  }, {
    "dbId" : 10245340,
    "stId" : "R-CFA-202475",
    "displayName" : "Bcl10 trimer bound to CARMA1 trimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84565 ],
    "parents" : [ 10245348 ],
    "children" : [ 10245331, 10245338 ]
  }, {
    "dbId" : 10245085,
    "stId" : "R-CFA-202228",
    "displayName" : "phospho-CD3E [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "P27597",
    "standardIdentifier" : "uniprot:P27597",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD3E" ],
    "parents" : [ 10245097, 10245091 ],
    "children" : [ ]
  }, {
    "dbId" : 10253022,
    "stId" : "R-CFA-211604",
    "displayName" : "PAK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3QD39",
    "standardIdentifier" : "uniprot:A0A8I3QD39",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10253034 ],
    "children" : [ ]
  }, {
    "dbId" : 10243551,
    "stId" : "R-CFA-197906",
    "displayName" : "CD3E [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "P27597",
    "standardIdentifier" : "uniprot:P27597",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD3E" ],
    "parents" : [ 10243557, 10243563 ],
    "children" : [ ]
  }, {
    "dbId" : 10253016,
    "stId" : "R-CFA-162629",
    "displayName" : "PAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NMF7",
    "standardIdentifier" : "uniprot:A0A8I3NMF7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PAK1" ],
    "parents" : [ 10253034 ],
    "children" : [ ]
  }, {
    "dbId" : 10245081,
    "stId" : "R-CFA-202266",
    "displayName" : "Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84454, 84540 ],
    "parents" : [ ],
    "children" : [ 10243569, 10245079, 10245051, 10245049 ]
  }, {
    "dbId" : 10243545,
    "stId" : "R-CFA-198177",
    "displayName" : "TCR chain beta [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10243547 ],
    "children" : [ 10243539, 10243543, 10243535 ]
  }, {
    "dbId" : 10245338,
    "stId" : "R-CFA-202488",
    "displayName" : "phospho-BCL10 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84564 ],
    "identifier" : "A0A8I3MNA4",
    "standardIdentifier" : "uniprot:A0A8I3MNA4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BCL10" ],
    "parents" : [ 10245364, 10245340 ],
    "children" : [ ]
  }, {
    "dbId" : 10238426,
    "stId" : "R-CFA-939176",
    "displayName" : "UBA52 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "P63050",
    "standardIdentifier" : "uniprot:P63050",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBA52" ],
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10243547,
    "stId" : "R-CFA-198183",
    "displayName" : "T-cell receptor [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10243569, 10245109 ],
    "children" : [ 10243525, 10243545 ]
  }, {
    "dbId" : 10243285,
    "stId" : "R-CFA-168104",
    "displayName" : "CHUK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P499",
    "standardIdentifier" : "uniprot:A0A8I3P499",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CHUK" ],
    "parents" : [ 10245412, 10245379, 10245377 ],
    "children" : [ ]
  }, {
    "dbId" : 10245077,
    "stId" : "R-CFA-2213189",
    "displayName" : "MHC class II alpha/beta dimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10245079 ],
    "children" : [ 10245075, 10245063 ]
  }, {
    "dbId" : 10245079,
    "stId" : "R-CFA-203463",
    "displayName" : "MHC Class II bearing antigen peptide [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10245167, 10245171, 10245081, 10245111 ],
    "children" : [ 2213228, 10245077 ]
  }, {
    "dbId" : 10243543,
    "stId" : "R-CFA-198181",
    "displayName" : "TRBV12-3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P564",
    "standardIdentifier" : "uniprot:A0A8I3P564",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10243545 ],
    "children" : [ ]
  }, {
    "dbId" : 10238417,
    "stId" : "R-CFA-939224",
    "displayName" : "RPS27A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NFB9",
    "standardIdentifier" : "uniprot:A0A8I3NFB9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RPS27A" ],
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 2213228,
    "stId" : "R-ALL-2213228",
    "displayName" : "MHC class II epitopes [plasma membrane]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "parents" : [ 10245079 ],
    "children" : [ ]
  }, {
    "dbId" : 10245331,
    "stId" : "R-CFA-202445",
    "displayName" : "CARMA1 trimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84554 ],
    "parents" : [ 10245362, 10245364, 10245340 ],
    "children" : [ 10245042, 10245324 ]
  }, {
    "dbId" : 10245075,
    "stId" : "R-CFA-2130476",
    "displayName" : "HLA II beta chain [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10245077 ],
    "children" : [ 10245067, 10245071 ]
  }, {
    "dbId" : 10243539,
    "stId" : "R-CFA-198187",
    "displayName" : "TCRB [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PAB8",
    "standardIdentifier" : "uniprot:A0A8I3PAB8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10243545 ],
    "children" : [ ]
  }, {
    "dbId" : 10245324,
    "stId" : "R-CFA-202438",
    "displayName" : "phospho-CARD11 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84553 ],
    "identifier" : "A0A8I3NT57",
    "standardIdentifier" : "uniprot:A0A8I3NT57",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CARD11" ],
    "parents" : [ 10245326, 10245331 ],
    "children" : [ ]
  }, {
    "dbId" : 10243533,
    "stId" : "R-CFA-198188-2",
    "displayName" : "TRBC1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3S3J5",
    "standardIdentifier" : "uniprot:A0A8I3S3J5",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10243535 ],
    "children" : [ ]
  }, {
    "dbId" : 10245326,
    "stId" : "R-CFA-202440",
    "displayName" : "Activated CARMA1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84551 ],
    "parents" : [ ],
    "children" : [ 10245042, 10245324 ]
  }, {
    "dbId" : 10238414,
    "stId" : "R-CFA-939169",
    "displayName" : "Ub-63-UBA52(1-76) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PFZ3",
    "standardIdentifier" : "uniprot:A0A8I3PFZ3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10245071,
    "stId" : "R-CFA-197578",
    "displayName" : "HLA-DQB1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NTK0",
    "standardIdentifier" : "uniprot:A0A8I3NTK0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "HLA-DQB1" ],
    "parents" : [ 10245075 ],
    "children" : [ ]
  }, {
    "dbId" : 10243535,
    "stId" : "R-CFA-198188-3",
    "displayName" : "Homologues of TRBC1 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10243545 ],
    "children" : [ 10243529, 10243533 ]
  }, {
    "dbId" : 10243529,
    "stId" : "R-CFA-198188",
    "displayName" : "TRBC1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PF21",
    "standardIdentifier" : "uniprot:A0A8I3PF21",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10243535 ],
    "children" : [ ]
  }, {
    "dbId" : 10238411,
    "stId" : "R-CFA-939248",
    "displayName" : "Ub-63-RPS27A(1-76) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NUE4",
    "standardIdentifier" : "uniprot:A0A8I3NUE4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10245067,
    "stId" : "R-CFA-197648",
    "displayName" : "HLA class II histocompatibility antigen, DP [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P4A1",
    "standardIdentifier" : "uniprot:A0A8I3P4A1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10245075 ],
    "children" : [ ]
  }, {
    "dbId" : 10245316,
    "stId" : "R-CFA-984816",
    "displayName" : "phospho-PLCG2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NZG2",
    "standardIdentifier" : "uniprot:A0A8I3NZG2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PLCG2" ],
    "parents" : [ 10245318 ],
    "children" : [ ]
  }, {
    "dbId" : 10245061,
    "stId" : "R-CFA-197588",
    "displayName" : "HLA-DRA [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3S2N1",
    "standardIdentifier" : "uniprot:A0A8I3S2N1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "HLA-DRA" ],
    "parents" : [ 10245063 ],
    "children" : [ ]
  }, {
    "dbId" : 10243525,
    "stId" : "R-CFA-198184",
    "displayName" : "TCR chain alpha [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10243547 ],
    "children" : [ 10243523, 10243519 ]
  }, {
    "dbId" : 114520,
    "stId" : "R-ALL-114520",
    "displayName" : "I(1,4,5)P3 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84512 ],
    "identifier" : "203600",
    "standardIdentifier" : "chebi:203600",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245318,
    "stId" : "R-CFA-2029095",
    "displayName" : "p-PLCG [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 84513 ],
    "parents" : [ ],
    "children" : [ 10245316, 10245294 ]
  }, {
    "dbId" : 10245063,
    "stId" : "R-CFA-2130597",
    "displayName" : "HLA II alpha chain [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10245077 ],
    "children" : [ 10245061, 10245055 ]
  }, {
    "dbId" : 10243523,
    "stId" : "R-CFA-198176",
    "displayName" : "T-cell receptor alpha chain V region PY14 precursor [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MKK6",
    "standardIdentifier" : "uniprot:A0A8I3MKK6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10243525 ],
    "children" : [ ]
  }, {
    "dbId" : 10245118,
    "stId" : "R-CFA-202397",
    "displayName" : "ZAP70 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84461 ],
    "identifier" : "A0A8I3P8U2",
    "standardIdentifier" : "uniprot:A0A8I3P8U2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ZAP70" ],
    "parents" : [ 10245120 ],
    "children" : [ ]
  }, {
    "dbId" : 10245364,
    "stId" : "R-CFA-202480",
    "displayName" : "Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84561 ],
    "parents" : [ ],
    "children" : [ 10245331, 10245338 ]
  }, {
    "dbId" : 10238452,
    "stId" : "R-CFA-450143",
    "displayName" : "K63-Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10238454 ],
    "children" : [ 10238417, 10238411, 10238426, 10238414 ]
  }, {
    "dbId" : 10245109,
    "stId" : "R-CFA-203493",
    "displayName" : "T-cell receptor complex with phosphorylated ITAMs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10245111 ],
    "children" : [ 10245107, 10245091, 10243547, 10245097 ]
  }, {
    "dbId" : 10238454,
    "stId" : "R-CFA-450152",
    "displayName" : "K63polyUb [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 49646,
    "diagramIds" : [ 84588, 84574 ],
    "parents" : [ ],
    "children" : [ 10238452 ]
  }, {
    "dbId" : 10245111,
    "stId" : "R-CFA-203494",
    "displayName" : "Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84458 ],
    "parents" : [ 10245120, 10245125, 10245133 ],
    "children" : [ 10245079, 10245109, 10245051, 10245049 ]
  }, {
    "dbId" : 10245360,
    "stId" : "R-CFA-202447",
    "displayName" : "BCL10 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84556 ],
    "identifier" : "A0A8I3MNA4",
    "standardIdentifier" : "uniprot:A0A8I3MNA4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BCL10" ],
    "parents" : [ 10245362 ],
    "children" : [ ]
  }, {
    "dbId" : 10243569,
    "stId" : "R-CFA-198901",
    "displayName" : "T-cell receptor complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10245167, 10245171, 10245081 ],
    "children" : [ 10243557, 10243563, 10243547, 10243567 ]
  }, {
    "dbId" : 10245105,
    "stId" : "R-CFA-202166",
    "displayName" : "phospho-CD247 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MV98",
    "standardIdentifier" : "uniprot:A0A8I3MV98",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD247" ],
    "parents" : [ 10245107 ],
    "children" : [ ]
  }, {
    "dbId" : 10245362,
    "stId" : "R-CFA-202454",
    "displayName" : "Bcl10 bound to CARMA1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84557 ],
    "parents" : [ ],
    "children" : [ 10245331, 10245360 ]
  }, {
    "dbId" : 10245107,
    "stId" : "R-CFA-202303",
    "displayName" : "p-6Y-CD247 dimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10245109 ],
    "children" : [ 10245105 ]
  }, {
    "dbId" : 10243567,
    "stId" : "R-CFA-198166",
    "displayName" : "CD247 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MV98",
    "standardIdentifier" : "uniprot:A0A8I3MV98",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD247" ],
    "parents" : [ 10243569 ],
    "children" : [ ]
  }, {
    "dbId" : 10245353,
    "stId" : "R-CFA-2685681",
    "displayName" : "TRAF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P2V4",
    "standardIdentifier" : "uniprot:A0A8I3P2V4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10245355 ],
    "children" : [ ]
  }, {
    "dbId" : 10243561,
    "stId" : "R-CFA-197917",
    "displayName" : "CD3G [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MFY1",
    "standardIdentifier" : "uniprot:A0A8I3MFY1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD3G" ],
    "parents" : [ 10243563 ],
    "children" : [ ]
  }, {
    "dbId" : 10245097,
    "stId" : "R-CFA-202167",
    "displayName" : "CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10245109 ],
    "children" : [ 10245095, 10245085 ]
  }, {
    "dbId" : 10253034,
    "stId" : "R-CFA-390765",
    "displayName" : "PAK1,2,3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 84598 ],
    "parents" : [ 10256491 ],
    "children" : [ 10253028, 10253016, 10253022 ]
  }, {
    "dbId" : 10245355,
    "stId" : "R-CFA-202456",
    "displayName" : "Ub-TRAF6 trimer bound to CBM complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84575 ],
    "parents" : [ 10245393 ],
    "children" : [ 10245348, 10245353 ]
  }, {
    "dbId" : 10243563,
    "stId" : "R-CFA-198902",
    "displayName" : "CD3 epsilon gamma [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10243569 ],
    "children" : [ 10243561, 10243551 ]
  }, {
    "dbId" : 10245348,
    "stId" : "R-CFA-202468",
    "displayName" : "MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84568 ],
    "parents" : [ 10245350, 10245355 ],
    "children" : [ 10245346, 10245340 ]
  }, {
    "dbId" : 10253028,
    "stId" : "R-CFA-428457",
    "displayName" : "PAK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PNN9",
    "standardIdentifier" : "uniprot:A0A8I3PNN9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10253034 ],
    "children" : [ ]
  }, {
    "dbId" : 10243557,
    "stId" : "R-CFA-198900",
    "displayName" : "CD3 epsilon delta [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10243569 ],
    "children" : [ 10243555, 10243551 ]
  }, {
    "dbId" : 10245350,
    "stId" : "R-CFA-202471",
    "displayName" : "TRAF6 trimer bound to CBM complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84571 ],
    "parents" : [ ],
    "children" : [ 10245348, 10238140 ]
  }, {
    "dbId" : 10245095,
    "stId" : "R-CFA-202362",
    "displayName" : "phospho-CD3G [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MFY1",
    "standardIdentifier" : "uniprot:A0A8I3MFY1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD3G" ],
    "parents" : [ 10245097 ],
    "children" : [ ]
  }, {
    "dbId" : 179838,
    "stId" : "R-ALL-179838",
    "displayName" : "PI(3,4,5)P3 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84521 ],
    "identifier" : "57836",
    "standardIdentifier" : "chebi:57836",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 202277 ],
    "children" : [ ]
  }, {
    "dbId" : 10245344,
    "stId" : "R-CFA-202461",
    "displayName" : "MALT1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RR14",
    "standardIdentifier" : "uniprot:A0A8I3RR14",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MALT1" ],
    "parents" : [ 10245346 ],
    "children" : [ ]
  }, {
    "dbId" : 10245089,
    "stId" : "R-CFA-202329",
    "displayName" : "phospho-CD3D [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MJ11",
    "standardIdentifier" : "uniprot:A0A8I3MJ11",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD3D" ],
    "parents" : [ 10245091 ],
    "children" : [ ]
  }, {
    "dbId" : 10245346,
    "stId" : "R-CFA-202487",
    "displayName" : "MALT1 trimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84567 ],
    "parents" : [ 10245348 ],
    "children" : [ 10245344 ]
  }, {
    "dbId" : 10243555,
    "stId" : "R-CFA-198171",
    "displayName" : "CD3D [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MJ11",
    "standardIdentifier" : "uniprot:A0A8I3MJ11",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CD3D" ],
    "parents" : [ 10243557 ],
    "children" : [ ]
  }, {
    "dbId" : 10245091,
    "stId" : "R-CFA-202336",
    "displayName" : "CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10245109 ],
    "children" : [ 10245089, 10245085 ]
  }, {
    "dbId" : 10245149,
    "stId" : "R-CFA-202320",
    "displayName" : "PLCG1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84490 ],
    "identifier" : "A0A8I3SCI7",
    "standardIdentifier" : "uniprot:A0A8I3SCI7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PLCG1" ],
    "parents" : [ 10245245, 10245160 ],
    "children" : [ ]
  }, {
    "dbId" : 10238488,
    "stId" : "R-CFA-202463",
    "displayName" : "UBE2N:UBE2V1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84587, 84573 ],
    "parents" : [ ],
    "children" : [ 10238482, 10238486 ]
  }, {
    "dbId" : 10245401,
    "stId" : "R-CFA-202504",
    "displayName" : "TAB2/TAK1 complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84577 ],
    "parents" : [ ],
    "children" : [ 10245399, 10245383 ]
  }, {
    "dbId" : 10245145,
    "stId" : "R-CFA-202283",
    "displayName" : "PI3K bound to TRAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84517 ],
    "parents" : [ ],
    "children" : [ 10245143, 10231204 ]
  }, {
    "dbId" : 10238486,
    "stId" : "R-CFA-205753",
    "displayName" : "UBE2V1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "E2R2I5",
    "standardIdentifier" : "uniprot:E2R2I5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2V1" ],
    "parents" : [ 10238488 ],
    "children" : [ ]
  }, {
    "dbId" : 10245399,
    "stId" : "R-CFA-168163",
    "displayName" : "phospho-MAP3K7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N7L6",
    "standardIdentifier" : "uniprot:A0A8I3N7L6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP3K7" ],
    "parents" : [ 10245401 ],
    "children" : [ ]
  }, {
    "dbId" : 10245143,
    "stId" : "R-CFA-202201",
    "displayName" : "phospho-TRAT1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84515 ],
    "identifier" : "A0A8I3PR42",
    "standardIdentifier" : "uniprot:A0A8I3PR42",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAT1" ],
    "parents" : [ 10245145 ],
    "children" : [ ]
  }, {
    "dbId" : 10238480,
    "stId" : "R-CFA-206072-2",
    "displayName" : "UBE2N [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PGB2",
    "standardIdentifier" : "uniprot:A0A8I3PGB2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238482 ],
    "children" : [ ]
  }, {
    "dbId" : 10245393,
    "stId" : "R-CFA-202507",
    "displayName" : "TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84579 ],
    "parents" : [ ],
    "children" : [ 10245355, 10245391 ]
  }, {
    "dbId" : 10238482,
    "stId" : "R-CFA-206072-3",
    "displayName" : "Homologues of UBE2N [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10238488 ],
    "children" : [ 10238480, 10238478 ]
  }, {
    "dbId" : 10245389,
    "stId" : "R-CFA-202527",
    "displayName" : "phospho-MAP3K7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N7L6",
    "standardIdentifier" : "uniprot:A0A8I3N7L6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP3K7" ],
    "parents" : [ 10245391 ],
    "children" : [ ]
  }, {
    "dbId" : 10245133,
    "stId" : "R-CFA-202181",
    "displayName" : "Activated ZAP-70 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84469 ],
    "parents" : [ 10245266 ],
    "children" : [ 10245111, 10245131 ]
  }, {
    "dbId" : 179856,
    "stId" : "R-ALL-179856",
    "displayName" : "PI(4,5)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84609, 84520, 84507 ],
    "identifier" : "58456",
    "standardIdentifier" : "chebi:58456",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10245296 ],
    "children" : [ ]
  }, {
    "dbId" : 112275,
    "stId" : "R-ALL-112275",
    "displayName" : "DAGs [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84534, 84511 ],
    "identifier" : "18035",
    "standardIdentifier" : "chebi:18035",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10245218, 10245281, 10245211 ],
    "children" : [ ]
  }, {
    "dbId" : 10238478,
    "stId" : "R-CFA-206072",
    "displayName" : "UBE2N [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P6I7",
    "standardIdentifier" : "uniprot:A0A8I3P6I7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2N" ],
    "parents" : [ 10238482 ],
    "children" : [ ]
  }, {
    "dbId" : 10245391,
    "stId" : "R-CFA-202516",
    "displayName" : "phosphorylated TAK1 bound to TAB2 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10245393 ],
    "children" : [ 10245383, 10245389 ]
  }, {
    "dbId" : 10249231,
    "stId" : "R-CFA-197954",
    "displayName" : "NCK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84595 ],
    "identifier" : "A0A8I3S602",
    "standardIdentifier" : "uniprot:A0A8I3S602",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NCK1" ],
    "parents" : [ 10256489 ],
    "children" : [ ]
  }, {
    "dbId" : 10245131,
    "stId" : "R-CFA-202252",
    "displayName" : "phospho-ZAP70 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P8U2",
    "standardIdentifier" : "uniprot:A0A8I3P8U2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ZAP70" ],
    "parents" : [ 10245133 ],
    "children" : [ ]
  }, {
    "dbId" : 10245125,
    "stId" : "R-CFA-202345",
    "displayName" : "phospho tyrosine ZAP-70 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84465 ],
    "parents" : [ ],
    "children" : [ 10245123, 10245111 ]
  }, {
    "dbId" : 10245383,
    "stId" : "R-CFA-168116",
    "displayName" : "TAB2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P4Z1",
    "standardIdentifier" : "uniprot:A0A8I3P4Z1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB2" ],
    "parents" : [ 10245401, 10245391 ],
    "children" : [ ]
  }, {
    "dbId" : 10245120,
    "stId" : "R-CFA-202330",
    "displayName" : "ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84462 ],
    "parents" : [ ],
    "children" : [ 10245111, 10245118 ]
  }, {
    "dbId" : 10245377,
    "stId" : "R-CFA-168113",
    "displayName" : "CHUK:IKBKB:IKBKG [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84582 ],
    "parents" : [ ],
    "children" : [ 10242455, 10238278, 10243285 ]
  }, {
    "dbId" : 10245379,
    "stId" : "R-CFA-202513",
    "displayName" : "CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84584 ],
    "parents" : [ ],
    "children" : [ 10238290, 10238278, 10243285 ]
  }, {
    "dbId" : 10245123,
    "stId" : "R-CFA-202368",
    "displayName" : "phospho-ZAP70 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P8U2",
    "standardIdentifier" : "uniprot:A0A8I3P8U2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ZAP70" ],
    "parents" : [ 10245125 ],
    "children" : [ ]
  }, {
    "dbId" : 10245181,
    "stId" : "R-CFA-6785270",
    "displayName" : "CD45,CD148 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 84448 ],
    "parents" : [ ],
    "children" : [ 10245175, 10245179 ]
  }, {
    "dbId" : 10245179,
    "stId" : "R-CFA-6785269",
    "displayName" : "PTPRJ [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P598",
    "standardIdentifier" : "uniprot:A0A8I3P598",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PTPRJ" ],
    "parents" : [ 10245181 ],
    "children" : [ ]
  }, {
    "dbId" : 10245175,
    "stId" : "R-CFA-197931",
    "displayName" : "PTPRC [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PV90",
    "standardIdentifier" : "uniprot:A0A8I3PV90",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PTPRC" ],
    "parents" : [ 10245181 ],
    "children" : [ ]
  }, {
    "dbId" : 29356,
    "stId" : "R-ALL-29356",
    "displayName" : "H2O [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84450, 84601, 84524, 84606, 84510 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245169,
    "stId" : "R-CFA-167609",
    "displayName" : "LCK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NAC6",
    "standardIdentifier" : "uniprot:A0A8I3NAC6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LCK" ],
    "parents" : [ 10245171 ],
    "children" : [ ]
  }, {
    "dbId" : 10245171,
    "stId" : "R-CFA-202157",
    "displayName" : "Antigen-bearing MHC Class II  : TCR complex:CD4:Lck [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84444 ],
    "parents" : [ ],
    "children" : [ 10245169, 10243569, 10245079, 10245051 ]
  }, {
    "dbId" : 10245165,
    "stId" : "R-CFA-202159",
    "displayName" : "phospho-LCK [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NAC6",
    "standardIdentifier" : "uniprot:A0A8I3NAC6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LCK" ],
    "parents" : [ 10245167 ],
    "children" : [ ]
  }, {
    "dbId" : 10245167,
    "stId" : "R-CFA-202154",
    "displayName" : "Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84447 ],
    "parents" : [ ],
    "children" : [ 10243569, 10245079, 10245051, 10245165 ]
  }, {
    "dbId" : 10245160,
    "stId" : "R-CFA-202240",
    "displayName" : "PLCG1:p-5Y-LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84493 ],
    "parents" : [ 10245247 ],
    "children" : [ 10245158, 10245149 ]
  }, {
    "dbId" : 10245412,
    "stId" : "R-CFA-202562",
    "displayName" : "CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84589 ],
    "parents" : [ ],
    "children" : [ 10245410, 10238290, 10243285 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84483, 84578, 84453, 84549, 84583, 84519, 84457, 84559, 84464, 84496, 84468, 84537, 84472, 84445, 84542 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84544, 84485, 84580, 84455, 84550, 84585, 84459, 84522, 84560, 84466, 84498, 84470, 84539, 84475, 84446 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245158,
    "stId" : "R-CFA-202364",
    "displayName" : "phospho-LAT [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84474 ],
    "identifier" : "A0A8I3MMK3",
    "standardIdentifier" : "uniprot:A0A8I3MMK3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LAT" ],
    "parents" : [ 10245254, 10245160, 10245190 ],
    "children" : [ ]
  }, {
    "dbId" : 10329121,
    "stId" : "R-CFA-1257604",
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 84618 ]
  }, {
    "dbId" : 29372,
    "stId" : "R-ALL-29372",
    "displayName" : "Pi [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 84451, 84607, 84526 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245410,
    "stId" : "R-CFA-202530",
    "displayName" : "IKBKG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3S792",
    "standardIdentifier" : "uniprot:A0A8I3S792",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKG" ],
    "parents" : [ 10245412 ],
    "children" : [ ]
  }, {
    "dbId" : 10256479,
    "stId" : "R-CFA-430124",
    "displayName" : "p-SLP-76:ADAP [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84593 ],
    "parents" : [ ],
    "children" : [ 10253395, 10245201 ]
  }, {
    "dbId" : 10245209,
    "stId" : "R-CFA-202395",
    "displayName" : "phospho-PRKCQ [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RRL7",
    "standardIdentifier" : "uniprot:A0A8I3RRL7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PRKCQ" ],
    "parents" : [ 10245211 ],
    "children" : [ ]
  }, {
    "dbId" : 10245211,
    "stId" : "R-CFA-202300",
    "displayName" : "p-Y90-PKC-theta:DAG [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84538 ],
    "parents" : [ ],
    "children" : [ 10245209, 112275 ]
  }, {
    "dbId" : 10245201,
    "stId" : "R-CFA-202175",
    "displayName" : "phospho-LCP2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84591 ],
    "identifier" : "A0A8I3MGV8",
    "standardIdentifier" : "uniprot:A0A8I3MGV8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LCP2" ],
    "parents" : [ 10256479, 10256489, 10245203 ],
    "children" : [ ]
  }, {
    "dbId" : 10238290,
    "stId" : "R-CFA-202506",
    "displayName" : "phospho-IKBKB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N4F2",
    "standardIdentifier" : "uniprot:A0A8I3N4F2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKB" ],
    "parents" : [ 10245412, 10245379 ],
    "children" : [ ]
  }, {
    "dbId" : 10245203,
    "stId" : "R-CFA-202162",
    "displayName" : "p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84484 ],
    "parents" : [ 10245256, 10245245, 10245264 ],
    "children" : [ 10245201, 10245190 ]
  }, {
    "dbId" : 10253395,
    "stId" : "R-CFA-390925",
    "displayName" : "FYB1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84592 ],
    "identifier" : "A0A8I3MMZ1",
    "standardIdentifier" : "uniprot:A0A8I3MMZ1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FYB1" ],
    "parents" : [ 10256479 ],
    "children" : [ ]
  }, {
    "dbId" : 10245196,
    "stId" : "R-CFA-202151",
    "displayName" : "SLP-76 bound to Gads:LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84481 ],
    "parents" : [ ],
    "children" : [ 10245190, 10245194 ]
  }, {
    "dbId" : 10245194,
    "stId" : "R-CFA-202306",
    "displayName" : "LCP2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84480 ],
    "identifier" : "A0A8I3MGV8",
    "standardIdentifier" : "uniprot:A0A8I3MGV8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LCP2" ],
    "parents" : [ 10245196 ],
    "children" : [ ]
  }, {
    "dbId" : 10245188,
    "stId" : "R-CFA-202367",
    "displayName" : "GRAP2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84477 ],
    "identifier" : "A0A8I3P6Q8",
    "standardIdentifier" : "uniprot:A0A8I3P6Q8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GRAP2" ],
    "parents" : [ 10245190 ],
    "children" : [ ]
  }, {
    "dbId" : 10307397,
    "stId" : "R-CFA-8852205",
    "displayName" : "PTPN22 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84602 ],
    "identifier" : "A0A8I3PC26",
    "standardIdentifier" : "uniprot:A0A8I3PC26",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PTPN22" ],
    "parents" : [ 10307994 ],
    "children" : [ ]
  }, {
    "dbId" : 10233414,
    "stId" : "R-CFA-61459",
    "displayName" : "PDPK1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MQX7",
    "standardIdentifier" : "uniprot:A0A8I3MQX7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PDPK1" ],
    "parents" : [ 10245042 ],
    "children" : [ ]
  }, {
    "dbId" : 10238278,
    "stId" : "R-CFA-168108",
    "displayName" : "IKBKG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3S792",
    "standardIdentifier" : "uniprot:A0A8I3S792",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKG" ],
    "parents" : [ 10245379, 10245377 ],
    "children" : [ ]
  }, {
    "dbId" : 10245190,
    "stId" : "R-CFA-202177",
    "displayName" : "GADS:p-5Y-LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84478 ],
    "parents" : [ 10245196, 10245203 ],
    "children" : [ 10245158, 10245188 ]
  }, {
    "dbId" : 10244674,
    "stId" : "R-CFA-58216",
    "displayName" : "PRKCQ [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84533 ],
    "identifier" : "A0A8I3RRL7",
    "standardIdentifier" : "uniprot:A0A8I3RRL7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PRKCQ" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245245,
    "stId" : "R-CFA-202279",
    "displayName" : "PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84491 ],
    "parents" : [ 10245247 ],
    "children" : [ 10245203, 10245149 ]
  }, {
    "dbId" : 10245247,
    "stId" : "R-CFA-202318",
    "displayName" : "PLC-gamma1 bound to LAT or SLP-76 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 84495 ],
    "parents" : [ ],
    "children" : [ 10245160, 10245245 ]
  }, {
    "dbId" : 10245240,
    "stId" : "R-CFA-202322",
    "displayName" : "LAT [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84473 ],
    "identifier" : "A0A8I3MMK3",
    "standardIdentifier" : "uniprot:A0A8I3MMK3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LAT" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245233,
    "stId" : "R-CFA-197940",
    "displayName" : "INPP5D [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84527 ],
    "identifier" : "A0A8I3PAP4",
    "standardIdentifier" : "uniprot:A0A8I3PAP4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "INPP5D" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10256489,
    "stId" : "R-CFA-430188",
    "displayName" : "p-SLP-76:NCK1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84596 ],
    "parents" : [ 10256491 ],
    "children" : [ 10245201, 10249231 ]
  }, {
    "dbId" : 10245225,
    "stId" : "R-CFA-202297",
    "displayName" : "Csk:p-PAG [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84442 ],
    "parents" : [ ],
    "children" : [ 10245223, 10240654 ]
  }, {
    "dbId" : 10256491,
    "stId" : "R-CFA-430189",
    "displayName" : "p-SLP-76:NCK:PAK [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84599 ],
    "parents" : [ ],
    "children" : [ 10253034, 10256489 ]
  }, {
    "dbId" : 10245223,
    "stId" : "R-CFA-203776",
    "displayName" : "CSK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 84441 ],
    "identifier" : "A0A8I3P4Z0",
    "standardIdentifier" : "uniprot:A0A8I3P4Z0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10307994, 10245225 ],
    "children" : [ ]
  }, {
    "dbId" : 10245216,
    "stId" : "R-CFA-202152",
    "displayName" : "phospho-PRKCQ [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RRL7",
    "standardIdentifier" : "uniprot:A0A8I3RRL7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PRKCQ" ],
    "parents" : [ 10245218 ],
    "children" : [ ]
  }, {
    "dbId" : 10245218,
    "stId" : "R-CFA-202442",
    "displayName" : "Active PKC theta bound to DAG [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 84543 ],
    "parents" : [ ],
    "children" : [ 10245216, 112275 ]
  } ],
  "edges" : [ {
    "dbId" : 10245404,
    "stId" : "R-CFA-202510",
    "displayName" : "Activation of TAK1-TAB2 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245358 ],
    "following" : [ 10245396 ],
    "inputs" : [ 113592, 10245355, 10245401 ],
    "outputs" : [ 10245393, 29370 ],
    "catalysts" : [ 10245401 ],
    "efs" : [ ],
    "diagramIds" : [ 84576 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245277,
    "stId" : "R-CFA-202291",
    "displayName" : "Activation of Lck",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245184 ],
    "following" : [ 10307400, 10245114 ],
    "inputs" : [ 10245171, 113592 ],
    "outputs" : [ 29370, 10245081 ],
    "catalysts" : [ 10245171 ],
    "efs" : [ ],
    "diagramIds" : [ 84452 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10307996,
    "stId" : "R-CFA-8855375",
    "displayName" : "PTPN22 dissociates from CSK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10307998, 10307400 ],
    "inputs" : [ 10307994 ],
    "outputs" : [ 10245223, 10307397 ],
    "efs" : [ ],
    "diagramIds" : [ 84603 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10307998,
    "stId" : "R-CFA-8855381",
    "displayName" : "PTPN22 dephosphorylates ZAP70",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245128, 10307996 ],
    "inputs" : [ 29356, 10245125 ],
    "outputs" : [ 10245120, 29372 ],
    "catalysts" : [ 10307397 ],
    "efs" : [ ],
    "diagramIds" : [ 84605 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245273,
    "stId" : "R-CFA-202248",
    "displayName" : "Phosphorylation of PLC-gamma1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245303, 10245162, 10245289 ],
    "following" : [ 10245298, 10247817, 10247819 ],
    "inputs" : [ 113592, 10245247 ],
    "outputs" : [ 29370, 10245258 ],
    "catalysts" : [ 10245266 ],
    "efs" : [ ],
    "inhibitors" : [ 10245271 ],
    "diagramIds" : [ 84494 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245147,
    "stId" : "R-CFA-202203",
    "displayName" : "Recruitment of PI3K to plasma membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245321 ],
    "following" : [ 10245301 ],
    "inputs" : [ 10245143, 10231204 ],
    "outputs" : [ 10245145 ],
    "efs" : [ ],
    "diagramIds" : [ 84514 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245396,
    "stId" : "R-CFA-202500",
    "displayName" : "Activation of IKK complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245404 ],
    "following" : [ 10245415 ],
    "inputs" : [ 10245377, 113592 ],
    "outputs" : [ 10245379, 29370 ],
    "catalysts" : [ 10245393 ],
    "efs" : [ ],
    "diagramIds" : [ 84581 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245333,
    "stId" : "R-CFA-202443",
    "displayName" : "Oligomerization of CARMA1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245329 ],
    "following" : [ 10245369 ],
    "inputs" : [ 10245326, 10245324 ],
    "outputs" : [ 10245331 ],
    "efs" : [ ],
    "diagramIds" : [ 84552 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245206,
    "stId" : "R-CFA-202216",
    "displayName" : "Phosphorylation of SLP-76",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245238 ],
    "following" : [ 10256481, 10245289, 10245303 ],
    "inputs" : [ 113592, 10245196 ],
    "outputs" : [ 10245203, 29370 ],
    "catalysts" : [ 10245133 ],
    "efs" : [ ],
    "diagramIds" : [ 84482 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245136,
    "stId" : "R-CFA-202174",
    "displayName" : "Activation of ZAP-70",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245128 ],
    "following" : [ 10245243 ],
    "inputs" : [ 113592, 10245125 ],
    "outputs" : [ 29370, 10245133 ],
    "catalysts" : [ 10245125 ],
    "efs" : [ ],
    "diagramIds" : [ 84467 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245329,
    "stId" : "R-CFA-202437",
    "displayName" : "Phosphorylation of CARMA1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245311 ],
    "following" : [ 10245333 ],
    "inputs" : [ 113592, 10245309 ],
    "outputs" : [ 29370, 10245326 ],
    "catalysts" : [ 10245218 ],
    "efs" : [ ],
    "diagramIds" : [ 84548 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245128,
    "stId" : "R-CFA-202168",
    "displayName" : "Phosphorylation of ZAP-70 by Lck",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245291 ],
    "following" : [ 10307998, 10245136 ],
    "inputs" : [ 10245120, 113592 ],
    "outputs" : [ 29370, 10245125 ],
    "catalysts" : [ 10245081 ],
    "efs" : [ ],
    "diagramIds" : [ 84463 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10247817,
    "stId" : "R-CFA-213406",
    "displayName" : "Disassociation of PLC-gamma1 from LAT",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245273 ],
    "following" : [ 10245298 ],
    "inputs" : [ 10245254 ],
    "outputs" : [ 10245158, 10245252 ],
    "efs" : [ ],
    "diagramIds" : [ 84501 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245321,
    "stId" : "R-CFA-202407",
    "displayName" : "PLC-gamma1 hydrolyses PIP2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245298 ],
    "following" : [ 10245147 ],
    "inputs" : [ 29356, 179856 ],
    "outputs" : [ 114520, 112275 ],
    "catalysts" : [ 10245318 ],
    "efs" : [ ],
    "diagramIds" : [ 84509 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10307400,
    "stId" : "R-CFA-8852200",
    "displayName" : "Inactivation of LCK by PTPN22",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10307996, 10245277 ],
    "inputs" : [ 29356, 10245081 ],
    "outputs" : [ 10245171, 29372 ],
    "catalysts" : [ 10307397 ],
    "efs" : [ ],
    "diagramIds" : [ 84600 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10247819,
    "stId" : "R-CFA-213407",
    "displayName" : "Disassociation of PLC-gamma1 from SLP-76",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245273 ],
    "following" : [ 10245298 ],
    "inputs" : [ 10245256 ],
    "outputs" : [ 10245203, 10245252 ],
    "efs" : [ ],
    "diagramIds" : [ 84504 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245184,
    "stId" : "R-CFA-202214",
    "displayName" : "Dephosphorylation of Lck-pY505 by CD45",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245228 ],
    "following" : [ 10245277 ],
    "inputs" : [ 29356, 10245167 ],
    "outputs" : [ 10245171, 29372 ],
    "catalysts" : [ 10245181 ],
    "efs" : [ ],
    "diagramIds" : [ 84449 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245373,
    "stId" : "R-CFA-202478",
    "displayName" : "Interaction and oligomerization of MALT1 to Bcl10",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245375 ],
    "following" : [ 10245371 ],
    "inputs" : [ 10245346, 10245340 ],
    "outputs" : [ 10245348 ],
    "efs" : [ ],
    "diagramIds" : [ 84566 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245311,
    "stId" : "R-CFA-202394",
    "displayName" : "Translocation of CARMA1 to Plasma membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245221 ],
    "following" : [ 10245329 ],
    "inputs" : [ 10245042, 10245307 ],
    "outputs" : [ 10245309 ],
    "efs" : [ ],
    "diagramIds" : [ 84545 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245375,
    "stId" : "R-CFA-202489",
    "displayName" : "Oligomerization of Bcl10",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245367 ],
    "following" : [ 10245373 ],
    "inputs" : [ 10245364, 10245338 ],
    "outputs" : [ 10245340 ],
    "efs" : [ ],
    "diagramIds" : [ 84563 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245369,
    "stId" : "R-CFA-202466",
    "displayName" : "Interaction of Bcl10 to CARMA1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245333 ],
    "following" : [ 10245367 ],
    "inputs" : [ 10245331, 10245360 ],
    "outputs" : [ 10245362 ],
    "efs" : [ ],
    "diagramIds" : [ 84555 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245114,
    "stId" : "R-CFA-202165",
    "displayName" : "Phosphorylation of ITAM motifs in CD3 complexes",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245277 ],
    "following" : [ 10245291 ],
    "inputs" : [ 113592, 10245081 ],
    "outputs" : [ 10245111, 29370 ],
    "catalysts" : [ 10245081 ],
    "efs" : [ ],
    "diagramIds" : [ 84456 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245371,
    "stId" : "R-CFA-202472",
    "displayName" : "Translocation of TRAF6 to CBM complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245373 ],
    "following" : [ 10245358 ],
    "inputs" : [ 10245348, 10238140 ],
    "outputs" : [ 10245350 ],
    "efs" : [ ],
    "diagramIds" : [ 84569 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245243,
    "stId" : "R-CFA-202245",
    "displayName" : "Phosphorylation of TBSMs in LAT",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245136 ],
    "following" : [ 10245162, 10245285 ],
    "inputs" : [ 113592, 10245240 ],
    "outputs" : [ 29370, 10245158 ],
    "catalysts" : [ 10245133 ],
    "efs" : [ ],
    "diagramIds" : [ 84471 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245236,
    "stId" : "R-CFA-202237",
    "displayName" : "Hydrolysis of PIP3 to PI(3,4)P2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245301 ],
    "following" : [ 10245044 ],
    "inputs" : [ 29356, 179838 ],
    "outputs" : [ 29372, 202247 ],
    "catalysts" : [ 10245233 ],
    "efs" : [ ],
    "diagramIds" : [ 84523 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10244020,
    "stId" : "R-CFA-199456",
    "displayName" : "PTEN dephosphorylates PIP3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29356, 179838 ],
    "outputs" : [ 29372, 179856 ],
    "catalysts" : [ 10244017 ],
    "efs" : [ ],
    "diagramIds" : [ 84608 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245044,
    "stId" : "R-CFA-202164",
    "displayName" : "Translocation of PDK1 to Plasma membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245301, 10245236 ],
    "following" : [ 10245287 ],
    "inputs" : [ 10245040, 202277 ],
    "outputs" : [ 10245042 ],
    "efs" : [ ],
    "diagramIds" : [ 84528 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245301,
    "stId" : "R-CFA-202365",
    "displayName" : "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245147 ],
    "following" : [ 10245044, 10245236 ],
    "inputs" : [ 113592, 179856 ],
    "outputs" : [ 179838, 29370 ],
    "catalysts" : [ 10245145 ],
    "efs" : [ ],
    "diagramIds" : [ 84518 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245238,
    "stId" : "R-CFA-202241",
    "displayName" : "Recruitment of SLP-76 to Gads",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245285 ],
    "following" : [ 10245206 ],
    "inputs" : [ 10245190, 10245194 ],
    "outputs" : [ 10245196 ],
    "efs" : [ ],
    "diagramIds" : [ 84479 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245367,
    "stId" : "R-CFA-202459",
    "displayName" : "Phosphorylation of Bcl10",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245369 ],
    "following" : [ 10245375 ],
    "inputs" : [ 10245362, 113592 ],
    "outputs" : [ 29370, 10245364 ],
    "catalysts" : [ 10238394 ],
    "efs" : [ ],
    "diagramIds" : [ 84558 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245303,
    "stId" : "R-CFA-202375",
    "displayName" : "Recruitment of ITK to SLP-76",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245206 ],
    "following" : [ 10245273 ],
    "inputs" : [ 10245203, 10245262 ],
    "outputs" : [ 10245264 ],
    "efs" : [ ],
    "diagramIds" : [ 84486 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245298,
    "stId" : "R-CFA-202354",
    "displayName" : "Translocation of PLC-gamma1 to PIP2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10247819, 10245273, 10247817 ],
    "following" : [ 10245321 ],
    "inputs" : [ 10245252, 179856 ],
    "outputs" : [ 10245296 ],
    "efs" : [ ],
    "diagramIds" : [ 84506 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245228,
    "stId" : "R-CFA-202233",
    "displayName" : "Inactivation of Lck by Csk",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245796 ],
    "following" : [ 10245184 ],
    "inputs" : [ 10245171, 113592 ],
    "outputs" : [ 29370, 10245167 ],
    "catalysts" : [ 10245225 ],
    "efs" : [ ],
    "inhibitors" : [ 10245181 ],
    "diagramIds" : [ 84443 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10256493,
    "stId" : "R-CFA-430183",
    "displayName" : "NCK binds PAK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10253034, 10256489 ],
    "outputs" : [ 10256491 ],
    "efs" : [ ],
    "diagramIds" : [ 84597 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245358,
    "stId" : "R-CFA-202453",
    "displayName" : "Auto-ubiquitination of TRAF6",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245371 ],
    "following" : [ 10245404 ],
    "inputs" : [ 10238454, 10245350, 10238488 ],
    "outputs" : [ 10245355, 10238488 ],
    "catalysts" : [ 10245350 ],
    "efs" : [ ],
    "diagramIds" : [ 84572 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10256495,
    "stId" : "R-CFA-430190",
    "displayName" : "p-SLP-76 binds NCK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10245201, 10249231 ],
    "outputs" : [ 10256489 ],
    "efs" : [ ],
    "diagramIds" : [ 84594 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245289,
    "stId" : "R-CFA-202331",
    "displayName" : "Recruitment of PLC-gamma1 to SLP-76",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245206 ],
    "following" : [ 10245273 ],
    "inputs" : [ 10245203, 10245149 ],
    "outputs" : [ 10245245 ],
    "efs" : [ ],
    "diagramIds" : [ 84489 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245162,
    "stId" : "R-CFA-202212",
    "displayName" : "Recruitment of PLC-gamma1 to LAT",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245243 ],
    "following" : [ 10245273 ],
    "inputs" : [ 10245158, 10245149 ],
    "outputs" : [ 10245160 ],
    "efs" : [ ],
    "diagramIds" : [ 84492 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245291,
    "stId" : "R-CFA-202344",
    "displayName" : "Recruitment of ZAP-70 to phosphorylated ITAMs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245114 ],
    "following" : [ 10245128 ],
    "inputs" : [ 10245111, 10245118 ],
    "outputs" : [ 10245120 ],
    "efs" : [ ],
    "diagramIds" : [ 84460 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245796,
    "stId" : "R-CFA-203774",
    "displayName" : "Interaction of Csk with PAG",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10245228 ],
    "inputs" : [ 10245223, 10240654 ],
    "outputs" : [ 10245225 ],
    "efs" : [ ],
    "diagramIds" : [ 84439 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245221,
    "stId" : "R-CFA-202222",
    "displayName" : "Phosphorylation of PKC theta",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245283 ],
    "following" : [ 10245311 ],
    "inputs" : [ 113592, 10245211 ],
    "outputs" : [ 10245218, 29370 ],
    "catalysts" : [ 10245042 ],
    "efs" : [ ],
    "diagramIds" : [ 84541 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245285,
    "stId" : "R-CFA-202325",
    "displayName" : "Recruitment of Gads to LAT",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245243 ],
    "following" : [ 10245238 ],
    "inputs" : [ 10245158, 10245188 ],
    "outputs" : [ 10245190 ],
    "efs" : [ ],
    "diagramIds" : [ 84476 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245287,
    "stId" : "R-CFA-202328",
    "displayName" : "Translocation of PKC theta to plasma membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245044 ],
    "following" : [ 10245283 ],
    "inputs" : [ 10244674, 112275 ],
    "outputs" : [ 10245281 ],
    "efs" : [ ],
    "diagramIds" : [ 84532 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245415,
    "stId" : "R-CFA-202534",
    "displayName" : "Ubiquitination of NEMO by TRAF6",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10245396 ],
    "inputs" : [ 10245379, 10238454, 10238488 ],
    "outputs" : [ 10245412, 10238488 ],
    "catalysts" : [ 10245355 ],
    "efs" : [ ],
    "diagramIds" : [ 84586 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10256481,
    "stId" : "R-CFA-430135",
    "displayName" : "p-SLP-76 binds ADAP",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245206 ],
    "inputs" : [ 10253395, 10245201 ],
    "outputs" : [ 10256479 ],
    "efs" : [ ],
    "diagramIds" : [ 84590 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10245283,
    "stId" : "R-CFA-202307",
    "displayName" : "Change of PKC theta conformation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10245287 ],
    "following" : [ 10245221 ],
    "inputs" : [ 10245281, 113592 ],
    "outputs" : [ 29370, 10245211 ],
    "catalysts" : [ 10245081 ],
    "efs" : [ ],
    "diagramIds" : [ 84536 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10329861,
    "stId" : "R-CFA-202427",
    "displayName" : "Phosphorylation of CD3 and TCR zeta chains",
    "events" : [ 10245228, 10245277, 10307996, 10307400, 10245114, 10245796, 10245184 ]
  }, {
    "dbId" : 10329821,
    "stId" : "R-CFA-202424",
    "displayName" : "Downstream TCR signaling",
    "events" : [ 10245404, 10245373, 10245311, 10245375, 10245369, 10245147, 10245371, 10245236, 10244020, 10245044, 10245396, 10245301, 10245333, 10245367, 10245329, 10245358, 10245221, 10245287, 10245415, 10245283 ]
  }, {
    "dbId" : 10329863,
    "stId" : "R-CFA-202430",
    "displayName" : "Translocation of ZAP-70 to Immunological synapse",
    "events" : [ 10307998, 10245128, 10245291, 10245136 ]
  }, {
    "dbId" : 10329865,
    "stId" : "R-CFA-202433",
    "displayName" : "Generation of second messenger molecules",
    "events" : [ 10245273, 10245243, 10245238, 10245206, 10245303, 10245298, 10256493, 10256495, 10245289, 10247817, 10245321, 10245162, 10247819, 10245285, 10256481 ]
  } ]
}